CN102370663B - Application of pig nail in preparation of medicine or health product used for treating postnatal depression - Google Patents
Application of pig nail in preparation of medicine or health product used for treating postnatal depression Download PDFInfo
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- CN102370663B CN102370663B CN2010102578588A CN201010257858A CN102370663B CN 102370663 B CN102370663 B CN 102370663B CN 2010102578588 A CN2010102578588 A CN 2010102578588A CN 201010257858 A CN201010257858 A CN 201010257858A CN 102370663 B CN102370663 B CN 102370663B
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- postpartum depression
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Abstract
The invention discloses an application of pig nail in the preparation of a medicine or a health product used for treating postnatal depression. Pig nail is a traditional Chinese medicine material, and can be prepared into the medicine or the health product which can be taken by population with postnatal depression.
Description
Technical field
The present invention relates to a kind of animal raw Bauhinia variegata Linn that can be used for medicine or health food, is its purposes at preparation treatment postpartum depression effect medicine or health product specifically.
Technical background
Postpartum depression is meant the depressive symptom that the puerpera occurs in puerperal, belong to the neurosis category; Its clinical manifestation great majority occurred in initial three months of puerperal, also comprised in 1 year puerperal all depressions of morbidity, the cardinal symptom of postpartum depression be depressed, cry and the sadness of unknown cause; Some shows as irritability, anxiety, fear and symptom such as fear; Lacking power and boredom also is important relevant symptoms.
Postpartum depression initiatively neurological symptom comprise that appetite is low, lose weight, early sleep, tired, weak and constipation.Aspect cognitive, the postpartum depression power that can arouse attention is concentrated, forgetful and lack confidence; Some severe patient also can have sense of personal worth attenuating, feeling of helplessness and conscious sense of uselessness.Report OP property postpartum depression sickness rate is arranged at present more than 10%.
Be mainly to postpartum depression chemistry medicine at present: serotonin reuptake inhibitor, tricyclic antidepressant, monoamine hydrogenase inhibitor etc.; But these side effects of pharmaceutical drugs are relatively large; Especially for the women breast-feeding their children in puerperal, cause influence and injury neonate health through suckling easily; So Chinese medicine, Chinese medicine and western medicine combination or non-drug therapy receive publicity and accept extensively.
Chinese invention patent application number CN200910059224.9 has applied for " a kind of pharmaceutical composition and method for preparing and purposes of treating postpartum depression ", and it is by Radix Ginseng, Semen Ziziphi Spinosae, when being grouped into; Chinese invention patent application number CN200810144765.7 has applied for " medicine of treatment postpartum depression and preparation method thereof ", and it adopts Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Cortex Moutan, Fructus Gardeniae, Herba Menthae, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Fructus Tritici Levis, Fructus Jujubae, Radix Curcumae, Radix Et Rhizoma Nardostachyos, Bulbus Lilii, Radix Rehmanniae, Herba Albiziae, Radix Glycyrrhizae to form.
Unguis Sus domestica is used as medicine, and is promptly on the books in Shennong's Herbal; Compendium of Material Medica records " dewclaw first "; Other all on the books like " herbal classic ", " Mingyi Bielu " etc.Among the people have a Unguis Sus domestica satin charcoal treatment function row metrorrhagia, and Ungula Sus domestica is used for the use of lactogenic, has advantages such as cheap, as to enrich, have no side effect in the medicine source, and Chinese medicine is thought Unguis Sus domestica, and property is flat, salty in the mouth.It has effects such as lactogenic, antiinflammatory the modern pharmacological research proof.Do not see bibliographical information but whether Unguis Sus domestica has the effect of treatment postpartum depression.
Summary of the invention
The object of the invention provides Unguis Sus domestica or its extract is treated the medicine of postpartum depression or the application in the health product in preparation.
Adopt Unguis Sus domestica or its extract as raw material, list is used or can be prepared into suitable oral any dosage form with other drug regimens with treatment postpartum depression by the conventional formulation method, like tablet, capsule, electuary, oral liquid, chewable tablet etc.Wherein other medicines with treatment postpartum depression comprise Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis etc.
The present invention is the Unguis Sus domestica that screening obtains having the treatment postpartum depression from raw material of Chinese medicine, can reach the purpose that alleviates postpartum depression, and have no side effect, and is suitable for postpartum depression and takes for a long time.
The specific embodiment
Below in conjunction with embodiment the present invention is done further elaboration, but be not limited to this.
Embodiment 1
1. clinical data
By following diagnostic criteria, select postpartum depression patient 58 examples of making a definite diagnosis.
2. diagnostic criteria
1. meet " Chinese mental disorder classification and diagnostic criteria " the 3rd edition (CCMD3) postpartum depression diagnostic criteria;
2. preceding 17 item ratings of HAMD (HAMD) >=18 minutes;
3. get rid of serious physical disease, brain organic disease, substance depilatory, drug allergy person;
4. do not use psychosis before the treatment.
3. Therapeutic Method
Select for use Unguis Sus domestica to prepare, take twice every day, each 100 milliliters by conventional decocting method; Other any antidepressant Chinese and western drugs is used in nonjoinder during the treatment, the patient is marked with preceding 17 of HAMD respectively at treatment is forward and backward.
4. efficacy assessment standard
" traditional Chinese medical science disease diagnosis criterion of therapeutical effect " and HAMD scale appraisal result with reference in June, 1994, State Administration of Traditional Chinese Medicine announced are formulated:
Recovery from illness: symptom complete obiteration, emotion recover normal, and the HAMD scoring descends >=75%;
Produce effects: cardinal symptom is clearly better, and emotion is basicly stable, and HAMD scoring descends >=50% but less than 75%;
Effectively: partial symptoms takes a turn for the better, and emotion has improvement, and the HAMD scoring descends >=25% but less than 50%:
Invalid: symptom and emotion all do not have improvement, and the HAMD scoring descends<25%.
5. result
Clinical total effects is cured 28 examples, produce effects 11 examples, effective 13 examples, invalid 6 examples, total effective rate 89.65%.
Preceding 17 item ratings of HAMD before and after the treatment are treated forward and backward HAMD scoring average and are respectively 28.12 ± 4.15 and 19.32 ± 5.17, before the HAMD scoring of treatment back is starkly lower than treatment, significant difference (P<0.05) are arranged relatively before and after the treatment.
Above clinical observation result explanation, Unguis Sus domestica decocting liquid has the effect that improves postpartum depression.
Claims (2)
1. Unguis Sus domestica decocting liquid list is used or is treated the medicine of postpartum depression effect or the application in the health product with other treatment postpartum depression drugs with function in preparation.
2. application according to claim 1, medicine wherein or health product are peroral dosage form.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2010102578588A CN102370663B (en) | 2010-08-18 | 2010-08-18 | Application of pig nail in preparation of medicine or health product used for treating postnatal depression |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN2010102578588A CN102370663B (en) | 2010-08-18 | 2010-08-18 | Application of pig nail in preparation of medicine or health product used for treating postnatal depression |
Publications (2)
Publication Number | Publication Date |
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CN102370663A CN102370663A (en) | 2012-03-14 |
CN102370663B true CN102370663B (en) | 2012-12-05 |
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CN2010102578588A Expired - Fee Related CN102370663B (en) | 2010-08-18 | 2010-08-18 | Application of pig nail in preparation of medicine or health product used for treating postnatal depression |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1459309A (en) * | 2002-05-21 | 2003-12-03 | 薛海川 | Plaster for treating proliferation of mammary gland |
CN101322830A (en) * | 2008-07-27 | 2008-12-17 | 麻爱华 | Medicament for treating postpartum depression and preparation method thereof |
CN101711809A (en) * | 2009-05-08 | 2010-05-26 | 成都中医药大学附属医院 | Medicine composition for treating postpartum melancholia, preparation method and application |
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2010
- 2010-08-18 CN CN2010102578588A patent/CN102370663B/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1459309A (en) * | 2002-05-21 | 2003-12-03 | 薛海川 | Plaster for treating proliferation of mammary gland |
CN101322830A (en) * | 2008-07-27 | 2008-12-17 | 麻爱华 | Medicament for treating postpartum depression and preparation method thereof |
CN101711809A (en) * | 2009-05-08 | 2010-05-26 | 成都中医药大学附属医院 | Medicine composition for treating postpartum melancholia, preparation method and application |
Non-Patent Citations (2)
Title |
---|
朱希强等.猪蹄甲的药用概况.《氨基酸和生物资源》.2000,第22卷(第2期),第43-46页. |
猪蹄甲的药用概况;朱希强等;《氨基酸和生物资源》;20001231;第22卷(第2期);第43-46页 * |
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Granted publication date: 20121205 Termination date: 20130818 |