CN103585471B - Traditional Chinese medicine composition for treating thrombocytopenia - Google Patents
Traditional Chinese medicine composition for treating thrombocytopenia Download PDFInfo
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- CN103585471B CN103585471B CN201310488650.0A CN201310488650A CN103585471B CN 103585471 B CN103585471 B CN 103585471B CN 201310488650 A CN201310488650 A CN 201310488650A CN 103585471 B CN103585471 B CN 103585471B
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Abstract
The invention relates to a traditional Chinese medicine composition for treating thrombocytopenia, belonging to the technical field of Chinese medicinal herbs. The composition is composed of the following active pharmaceutical ingredients: 90-110g of sun-dried ginseng, 90-110g of radix astragali, 90-110g of tuckahoe, 90-110g of stir-fried date kernel, 90-110g of radix paeoniae alba, 90-110g of dendrobe, 90-110g of hyacinth bletilla, 90-110g of angelica, 230-250g of pseudo-ginseng, 190-210g of donkey-hide gelatin, 290-310g of Chinese wolfberry, 290-310g of radix rehmanniae preparata, 190-210g of radix rehmanniae, 190-210g of herba agrimoniae, 290-310g of glossy privet fruit, 90-110g of cassia twig, 290-310g of sanguisorba, 290-310g of lotus node, 190-210g of tortoise-plastron glue, 40-60g of human placenta and 40-60g of licorice. The composition has the characteristics of accessible materials, simple manufacturing process, low cost, high practicality, small dosage, low content of harmful ingredients, no toxic or side effect, obvious curative effect and the like.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine composition being used for the treatment of thrombocytopenia.
Background technology
Thrombocytopenia causes tampon to be formed bad and hemorrhage because platelet counts reduces and causes.Thrombocytopenia can cause typically hemorrhage, as multiple ecchymosis, is most commonly in shank; Or there is little being dispersed in property ecchymosis at the position by microtrauma; Mucosal bleeding (epistaxis, gastrointestinal tract, urogenital tract and vaginal hemorrhage); Post operation is bled profusely.Gastrointestinal tract is bled profusely and central nervous system's internal hemorrhage severe patient can threat to life.Current western medical treatment thrombocytopenia choice drug is hormone, take rear platelet generally can raise, but the side effect of hormone is very large, many new diseases can be increased again while increased platelets counts, as central obesity, hypertension, diabetes, osteoporosis etc., and after hormone decrement, platelet can reduce again, still can recurrent exerbation after drug withdrawal.The feasible splenectomy of thrombocytopenia severe patient, but surgical risk is large, and patient itself is difficult to accept.Spleen is human immunity organ, causes patient immune function low, easily cause severe infections after cutting spleen, to patient body with bring misery mentally.
Motherland's medical science has carried out large quantifier elimination to treatment thrombocytopenia, has invented the medicine of many treatment thrombocytopenia.If the patent No. is the patent of CN200910094942.X, provide a kind of medicine for the treatment of thrombocytopenic purpura, it is made up of Rhizoma Smilacis Glabrae, Flos Lonicerae, Radix Arnebiae (Radix Lithospermi), Radix Rehmanniae, Cortex Mori, Concha Ostreae, Caulis et folium clerodendri bungei, Radix Scutellariae, Periostracum Cicadae.It has clearing away heat and cooling blood, hemostasis dissipating rashes, and promoting blood circulation to remove blood stasis, improves microcirculation, dredging the meridian, the effects such as eliminate pain, and do not add any chemicals, harmless to human non-toxic, taking convenience, energy enhancing body resistance and immunity, remove patient suffering, therapeutic effect is remarkable.For another example the patent No. is the patent of CN01106719.5, disclose a kind of medicine for the treatment of idiopathic thrombocytopenic purpura, be made up of Rhizoma Smilacis Glabrae, Radix Scutellariae, Radix Glycyrrhizae, the Radix Rehmanniae, Cortex Moutan, Herba Cirsii, Rhizoma Imperatae compatibility, this medicine can suppress antiplatelet antibody effectively, platelet is made to go back up to normal value, also there is good therapeutical effect for the abortion in first trimester patient caused due to platelet antibody simultaneously, the feature of this medicine is without taboo, toxic and side effects is little, curative effect is reliable, taking convenience, effective cure rate reaches 95%.
Summary of the invention
It is high that technical problem to be solved by this invention is to provide a kind of cure rate, the safe and reliable Chinese medicine composition being used for the treatment of thrombocytopenia.
Technical problem to be solved by this invention realizes by the following technical solutions:
Be used for the treatment of a Chinese medicine composition for thrombocytopenia, the medicament be made up of the crude drug of following weight,
Radix Ginseng 90-110g, Radix Astragali 90-110g, Poria 90-110g, Semen Ziziphi Spinosae (parched) 90-110g, Radix Paeoniae Alba 90-110g, Herba Dendrobii 90-110g, Pseudobulbus Bletillae (Rhizoma Bletillae) 90-110g, Radix Angelicae Sinensis 90-110g, Radix Notoginseng 230-250g, Colla Corii Asini 190-210g, Fructus Lycii 290-310g, Radix Rehmanniae Preparata 290-310g, Radix Rehmanniae 190-210g, Herba Agrimoniae 190-210g, Fructus Ligustri Lucidi 290-310g, Ramulus Cinnamomi 90-110g, Radix Sanguisorbae 290-310g, Nodus Nelumbinis Rhizomatis 290-310g, Colla Plastri Testudinis 190-210g, Placenta Hominis 40-60g, Radix Glycyrrhizae 40-60g.
Preferred weight part of each crude drug is: Radix Ginseng 100g, Radix Astragali 100g, Poria 100g, Semen Ziziphi Spinosae (parched) 100g, Radix Paeoniae Alba 100g, Herba Dendrobii 100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 100g, Radix Angelicae Sinensis 100g, Radix Notoginseng 240g, Colla Corii Asini 200g, Fructus Lycii 300g, Radix Rehmanniae Preparata 300g, Radix Rehmanniae 200g, Herba Agrimoniae 200g, Fructus Ligustri Lucidi 300g, Ramulus Cinnamomi 100g, Radix Sanguisorbae 300g, Nodus Nelumbinis Rhizomatis 300g, Colla Plastri Testudinis 200g, Placenta Hominis 50g, Radix Glycyrrhizae 50g.
Wherein said Radix Sanguisorbae selects Radix Sanguisorbae preparata, and the Radix Rehmanniae selects the stir-fry Radix Rehmanniae.
Crude drug used by the present invention can be bought from common Chinese shop and obtain, and its specification meets national Chinese crude drug standard.
Chinese medicine composition of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., the conventional oral formulations of any one is prepared into the method for Chinese medicinal of routine, wherein, described oral formulations can be decoction, pill, capsule or tablet.
Another object of the present invention is to provide a kind of method preparing the present composition, comprises the steps,
1) following each taste crude drug is taken by prescription weight number: Radix Ginseng 100g, Radix Astragali 100g, Poria 100g, Semen Ziziphi Spinosae (parched) 100g, Radix Paeoniae Alba 100g, Herba Dendrobii 100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 100g, Radix Angelicae Sinensis 100g, Radix Notoginseng 240g, Colla Corii Asini 200g, Fructus Lycii 300g, Radix Rehmanniae Preparata 300g, Radix Rehmanniae 200g, Herba Agrimoniae 200g, Fructus Ligustri Lucidi 300g, Ramulus Cinnamomi 100g, Radix Sanguisorbae 300g, Nodus Nelumbinis Rhizomatis 300g, Colla Plastri Testudinis 200g, Placenta Hominis 50g, Radix Glycyrrhizae 50g;
2) by above-mentioned each taste material medicine pulverization, mix homogeneously, adds Mel, furnishing pellet, high-temperature sterilization, every ball as Semen phaseoli radiati size, 0.04-0.6g.
Usage and consumption:
The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as the age of patient, body weight, health status.
Instruction: pill, adult 40g-60g every day, a point morning and evening takes after mixing it with water for 2 times; Child 10g-20g every day, a point morning and evening takes after mixing it with water for 2 times.Within two months, be a course for the treatment of, must adhere to taking lastingly for stubborn disease, can control.
Pharmacology analysis:
Select Placenta Hominis, Radix Ginseng, the Radix Astragali, Colla Corii Asini, Colla Plastri Testudinis, there is QI invigorating, nourishing blood function;
Select Semen Ziziphi Spinosae, Fructus Lycii, Radix Rehmanniae Preparata, Herba Dendrobii, the Radix Paeoniae Alba, Fructus Ligustri Lucidi, there is YIN nourishing tonify deficiency effect;
Select Ramulus Cinnamomi, Radix Sanguisorbae preparata, Nodus Nelumbinis Rhizomatis, the Radix Rehmanniae, the Pseudobulbus Bletillae (Rhizoma Bletillae), there is powerful hemostasia effect;
Select Mel, be taken at all things on earth elite, have and moisturize effect of promoting the production of body fluid.
Medicated diet prepared by the present invention has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and disease therapy, drops into the use link of disease therapy provide science and objective foundation to this medicine.Its test method and result of the test are distinguished as follows:
1. the pill that prepared by couple the present invention carries out animal acute toxicity test:
Medicine: the pill prepared by prescription of the present invention, is provided by The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine.
Experimental animal: white mice, body weight is at 30-50g, and male and female Stochastic choice, is provided by Medical University Of Anhui.
Method and result: get white mice 50, be divided into 5 groups, often organize 10, hungry 15 hours, fill with medicine feed thing by every only each 30g, in 24 hours, fill with medicine feed thing respectively 1,2,3,4,5 times for the 1st, 2,3,4,5 group, observe 5 days, white mice is movable normal, non-toxic reaction, without dead.Wherein white mice dosage is by kg body weight medicine calculation, shows that oral liquid is without acute toxicity, clinical medicine dose safety.
2. the pill that prepared by couple the present invention carries out long-term toxicity test for animals:
Experimental animal: rat, body weight, at 120-130g, all selects male white rat, is provided by Medical University Of Anhui.
Method and result: get rat 50, be divided into 5 groups, often organize 10, wherein the 1st, 2, 3, 4 groups as administration group, often organize and fill with medicine feed thing 15g respectively, 20g, 30g, 40g, 5th group of diet as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the change of tissues observed form, observe the effect of dosage, observe diet, movable change, experiment proves that administration group compares without significant change with matched group, a kind of safe drugs.
3. diagnostic criteria
1) in order to verify clinical efficacy, this prescription is tried out in First Attached Hospital, Anhui Medical Univ. and The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine respectively, and by random selecting wherein 50 routine adult patients, the course for the treatment of is the shortest is half a year, and what the course for the treatment of was the longest is 2 years.
3) Therapeutic Method
According to drug ratios of the present invention, take raw material (dose), the method according to usual preparation obtains pill, every day 50g, sooner or later service once, taking 30 days is a course for the treatment of.
4) efficacy determination:
Cure: Clinical symptom and sign disappears, functional activity recovers normal, follows up a case by regular visits to and does not recur for 1 year.
Effective: Clinical symptom and sign is clearly better or large portion disappears.
Invalid: bed symptom and sign is without improvement.
Concrete therapeutic outcome is see table 1.
Table 1
| Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage (%) |
| 50 | 8 | 25 | 15 | 2 | 96 |
The invention has the beneficial effects as follows: the present invention draws materials easily, make the features such as simple, with low cost, practicality is good, and taking dose is little, and Harmful ingredient content is low, has no side effect, evident in efficacy.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1
Each crude drug is taken: Radix Ginseng 100g, Radix Astragali 100g, Poria 100g, Semen Ziziphi Spinosae (parched) 100g, Radix Paeoniae Alba 100g, Herba Dendrobii 100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 100g, Radix Angelicae Sinensis 100g, Radix Notoginseng 240g, Colla Corii Asini 200g, Fructus Lycii 300g, Radix Rehmanniae Preparata 300g, Radix Rehmanniae 200g, Herba Agrimoniae 200g, Fructus Ligustri Lucidi 300g, Ramulus Cinnamomi 100g, Radix Sanguisorbae 300g, Nodus Nelumbinis Rhizomatis 300g, Colla Plastri Testudinis 200g, Placenta Hominis 50g, Radix Glycyrrhizae 50g by following weight;
By above-mentioned each taste material medicine pulverization, mix homogeneously, adds Mel, makes pellet, high-temperature sterilization, and every ball is as Semen phaseoli radiati size; Adult 40g-60g every day, a point morning and evening takes after mixing it with water for 2 times; Child 10g-20g every day, a point morning and evening takes after mixing it with water for 2 times.
Embodiment 2
Each crude drug is taken: Radix Ginseng 90g, Radix Astragali 90g, Poria 90g, Semen Ziziphi Spinosae (parched) 90g, Radix Paeoniae Alba 90g, Herba Dendrobii 90g, Pseudobulbus Bletillae (Rhizoma Bletillae) 90g, Radix Angelicae Sinensis 90g, Radix Notoginseng 230g, Colla Corii Asini 190g, Fructus Lycii 290g, Radix Rehmanniae Preparata 290g, Radix Rehmanniae 190g, Herba Agrimoniae 190g, Fructus Ligustri Lucidi 290g, Ramulus Cinnamomi 90g, Radix Sanguisorbae 290g, Nodus Nelumbinis Rhizomatis 290g, Colla Plastri Testudinis 190g, Placenta Hominis 40g, Radix Glycyrrhizae 40g by following weight.
By above-mentioned each taste material medicine pulverization, mix homogeneously, adds Mel, makes pellet, high-temperature sterilization, and every ball is as Semen phaseoli radiati size; Adult 40g-60g every day, a point morning and evening takes after mixing it with water for 2 times; Child 10g-20g every day, a point morning and evening takes after mixing it with water for 2 times.
Embodiment 3
Each crude drug is taken: Radix Ginseng 110g, Radix Astragali 110g, Poria 110g, Semen Ziziphi Spinosae (parched) 110g, Radix Paeoniae Alba 110g, Herba Dendrobii 110g, Pseudobulbus Bletillae (Rhizoma Bletillae) 110g, Radix Angelicae Sinensis 110g, Radix Notoginseng 250g, Colla Corii Asini 210g, Fructus Lycii 310g, Radix Rehmanniae Preparata 310g, Radix Rehmanniae 210g, Herba Agrimoniae 210g, Fructus Ligustri Lucidi 310g, Ramulus Cinnamomi 110g, Radix Sanguisorbae 310g, Nodus Nelumbinis Rhizomatis 310g, Colla Plastri Testudinis 210g, Placenta Hominis 60g, Radix Glycyrrhizae 60g by following weight.
By above-mentioned each taste material medicine pulverization, mix homogeneously, adds Mel, makes pellet, high-temperature sterilization, and every ball is as Semen phaseoli radiati size; Adult 40g-60g every day, a point morning and evening takes after mixing it with water for 2 times; Child 10g-20g every day, a point morning and evening takes after mixing it with water for 2 times.
Model case
Case 1
Understand so-and-so, man, 29 years old, people from Mingguang City, Anhui Province.Platelet minimizing property purpura before 3 years, through hospitalization effect time, front case is made a definite diagnosis, and fails to respond to any medical treatment through various method, platelet 22,100, and the side effect of hormone is apparent.By treatment by Chinese herbs of the present invention (Western medicine such as hormone of stopping using) 10 months, now cure completely, through inspections such as regular platelet, all normally.
Case 2
Take so-and-so, female, 38 years old, Anhui Province Fuyang City people.Because suffering from idiopathic thrombocytopenic purpura, aplastic anemia, leukopenia, platelet is down to less than 13,000, and Syndrome in TCM is shown in: white and thin fur, thready and rapid pulse is string slightly, pale complexion, moon face, the typical hormone side effect sign such as buffalo hump, by treatment by Chinese herbs of the present invention half a year, platelet rises to 21,000.Complexion slightly takes a turn for the better, and adhere to treatment, after 12 months, platelet rises to more than 180,000, and current complexion is good, and life is freely, uncomfortable without institute, can be normal see work.
Case 3
Zheng, female, 24 years old, people from Hefei City, Anhui Province, because acute primary thrombocytopenic purpura disease is rescued invalid in hospital at the beginning of 2005, platelet was down to more than 3,000.After take pill of the present invention, adhere to having taken 6 months, transference cure; After continue again to take 6 months, cure; Follow up a case by regular visits to and do not recur for 1 year.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (5)
1. one kind is used for the treatment of the Chinese medicine composition of thrombocytopenia, it is characterized in that, the medicament be made up of the crude drug of following weight: Radix Ginseng 90-110g, Radix Astragali 90-110g, Poria 90-110g, Semen Ziziphi Spinosae (parched) 90-110g, Radix Paeoniae Alba 90-110g, Herba Dendrobii 90-110g, Pseudobulbus Bletillae (Rhizoma Bletillae) 90-110g, Radix Angelicae Sinensis 90-110g, Radix Notoginseng 230-250g, Colla Corii Asini 190-210g, Fructus Lycii 290-310g, Radix Rehmanniae Preparata 290-310g, Radix Rehmanniae 190-210g, Herba Agrimoniae 190-210g, Fructus Ligustri Lucidi 290-310g, Ramulus Cinnamomi 90-110g, Radix Sanguisorbae 290-310g, Nodus Nelumbinis Rhizomatis 290-310g, Colla Plastri Testudinis 190-210g, Placenta Hominis 40-60g, Radix Glycyrrhizae 40-60g.
2. a kind of Chinese medicine composition being used for the treatment of thrombocytopenia according to claim 1, it is characterized in that, the medicament be made up of the crude drug of following weight: Radix Ginseng 100g, Radix Astragali 100g, Poria 100g, Semen Ziziphi Spinosae (parched) 100g, Radix Paeoniae Alba 100g, Herba Dendrobii 100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 100g, Radix Angelicae Sinensis 100g, Radix Notoginseng 240g, Colla Corii Asini 200g, Fructus Lycii 300g, Radix Rehmanniae Preparata 300g, Radix Rehmanniae 200g, Herba Agrimoniae 200g, Fructus Ligustri Lucidi 300g, Ramulus Cinnamomi 100g, Radix Sanguisorbae 300g, Nodus Nelumbinis Rhizomatis 300g, Colla Plastri Testudinis 200g, Placenta Hominis 50g, Radix Glycyrrhizae 50g.
3. a kind of Chinese medicine composition being used for the treatment of thrombocytopenia according to claim 1 and 2, is characterized in that: described medicament is the preparation that any one is suitable for clinically.
4. a kind of Chinese medicine composition being used for the treatment of thrombocytopenia according to claim 3, is characterized in that: described preparation is oral formulations.
5. a kind of Chinese medicine composition being used for the treatment of thrombocytopenia according to claim 4, is characterized in that: described oral formulations is pill.
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| CN105663419A (en) * | 2016-03-25 | 2016-06-15 | 杨忠雅 | Formula for pure traditional Chinese medicines capable of generating new blood, dispelling extravasated blood and treating leukemia |
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|---|---|---|---|---|
| CN1071582A (en) * | 1991-10-12 | 1993-05-05 | 龙孟麟 | Aplastic anemia is converted into leukemia |
| CN1157166A (en) * | 1996-01-25 | 1997-08-20 | 温顺明 | Xuefukang medicine |
| CN1160560A (en) * | 1996-03-21 | 1997-10-01 | 廖柏松 | Chinese patent drug for curing leukopenia and its preparation process |
| CN1181959A (en) * | 1997-07-09 | 1998-05-20 | 迟经惠 | Yin nourishing bolus for curing women's blood deficiency |
| CN1260983A (en) * | 1999-01-21 | 2000-07-26 | 仇殿明 | Process for preparing leukemia medicines |
| CN102210820A (en) * | 2011-05-24 | 2011-10-12 | 姜爱军 | Chinese medicinal composition for treating leukemia |
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2013
- 2013-10-18 CN CN201310488650.0A patent/CN103585471B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071582A (en) * | 1991-10-12 | 1993-05-05 | 龙孟麟 | Aplastic anemia is converted into leukemia |
| CN1157166A (en) * | 1996-01-25 | 1997-08-20 | 温顺明 | Xuefukang medicine |
| CN1160560A (en) * | 1996-03-21 | 1997-10-01 | 廖柏松 | Chinese patent drug for curing leukopenia and its preparation process |
| CN1181959A (en) * | 1997-07-09 | 1998-05-20 | 迟经惠 | Yin nourishing bolus for curing women's blood deficiency |
| CN1260983A (en) * | 1999-01-21 | 2000-07-26 | 仇殿明 | Process for preparing leukemia medicines |
| CN102210820A (en) * | 2011-05-24 | 2011-10-12 | 姜爱军 | Chinese medicinal composition for treating leukemia |
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