CN103585471A - Traditional Chinese medicine composition for treating thrombocytopenia - Google Patents
Traditional Chinese medicine composition for treating thrombocytopenia Download PDFInfo
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- CN103585471A CN103585471A CN201310488650.0A CN201310488650A CN103585471A CN 103585471 A CN103585471 A CN 103585471A CN 201310488650 A CN201310488650 A CN 201310488650A CN 103585471 A CN103585471 A CN 103585471A
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Abstract
The invention relates to a traditional Chinese medicine composition for treating thrombocytopenia, belonging to the technical field of Chinese medicinal herbs. The composition is composed of the following active pharmaceutical ingredients: 90-110g of sun-dried ginseng, 90-110g of radix astragali, 90-110g of tuckahoe, 90-110g of stir-fried date kernel, 90-110g of radix paeoniae alba, 90-110g of dendrobe, 90-110g of hyacinth bletilla, 90-110g of angelica, 230-250g of pseudo-ginseng, 190-210g of donkey-hide gelatin, 290-310g of Chinese wolfberry, 290-310g of radix rehmanniae preparata, 190-210g of radix rehmanniae, 190-210g of herba agrimoniae, 290-310g of glossy privet fruit, 90-110g of cassia twig, 290-310g of sanguisorba, 290-310g of lotus node, 190-210g of tortoise-plastron glue, 40-60g of human placenta and 40-60g of licorice. The composition has the characteristics of accessible materials, simple manufacturing process, low cost, high practicality, small dosage, low content of harmful ingredients, no toxic or side effect, obvious curative effect and the like.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine composition that is used for the treatment of thrombocytopenia.
Background technology
Thrombocytopenia causes tampon to form bad and hemorrhage causing because platelet counts reduces.Thrombocytopenia can cause typically hemorrhage, as multiple ecchymosis, is most commonly in shank; Or be subject to the position of microtrauma to occur little being dispersed in property ecchymosis; Mucosal bleeding (epistaxis, gastrointestinal tract, urogenital tract and vaginal hemorrhage); After operation, bleed profusely.Gastrointestinal tract is bled profusely and central nervous system's internal hemorrhage severe patient can threat to life.Western medical treatment thrombocytopenia choice drug is hormone at present, taking rear platelet generally can raise, but the side effect of hormone is very large, in increased platelets counts, can increase again many new diseases, as central obesity, hypertension, diabetes, osteoporosis etc., and after hormone decrement, platelet can reduce again, after drug withdrawal, still can repeatedly show effect.The feasible splenectomy of thrombocytopenia severe patient, but surgical risk is large, and patient itself is difficult to accept.Spleen is human immunity organ, causes patient immune function low after cutting spleen, easily causes severe infections, gives patient body and brings mentally misery.
Motherland's medical science has been carried out a large amount of research to treatment thrombocytopenia, has invented the medicine of many treatment thrombocytopenia.As the patent that the patent No. is CN200910094942.X, a kind of medicine for the treatment of thrombocytopenic purpura is provided, it is comprised of Rhizoma Smilacis Glabrae, Flos Lonicerae, Radix Arnebiae (Radix Lithospermi), Radix Rehmanniae, Cortex Mori, Concha Ostreae, Caulis et folium clerodendri bungei, Radix Scutellariae, Periostracum Cicadae.It has clearing away heat and cooling blood, hemostasis dissipating rashes, and promoting blood circulation to remove blood stasis, improves microcirculation, dredging the meridian, the effects such as eliminate pain, and do not add any chemicals, nontoxic to human body, taking convenience, energy enhancing body resistance and immunity, remove patient suffering, and therapeutic effect is remarkable.For another example the patent that the patent No. is CN01106719.5, a kind of medicine for the treatment of idiopathic thrombocytopenic purpura is disclosed, by Rhizoma Smilacis Glabrae, Radix Scutellariae, Radix Glycyrrhizae, the Radix Rehmanniae, Cortex Moutan, Herba Cirsii, Rhizoma Imperatae compatibility, formed, this medicine can suppress antiplatelet antibody effectively, make platelet go back up to normal value, for the abortion in first trimester patient who causes due to platelet antibody, also there is good therapeutical effect simultaneously, the feature of this medicine is without taboo, toxic and side effects is little, curative effect is reliable, taking convenience, effectively cure rate reaches 95%.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of cure rate high, the safe and reliable Chinese medicine composition that is used for the treatment of thrombocytopenia.
Technical problem to be solved by this invention realizes by the following technical solutions:
A Chinese medicine composition that is used for the treatment of thrombocytopenia, the medicament of being made by the crude drug of following weight,
Radix Ginseng 90-110g, Radix Astragali 90-110g, Poria 90-110g, Semen Ziziphi Spinosae (parched) 90-110g, Radix Paeoniae Alba 90-110g, Herba Dendrobii 90-110g, Pseudobulbus Bletillae (Rhizoma Bletillae) 90-110g, Radix Angelicae Sinensis 90-110g, Radix Notoginseng 230-250g, Colla Corii Asini 190-210g, Fructus Lycii 290-310g, Radix Rehmanniae Preparata 290-310g, Radix Rehmanniae 190-210g, Herba Agrimoniae 190-210g, Fructus Ligustri Lucidi 290-310g, Ramulus Cinnamomi 90-110g, Radix Sanguisorbae 290-310g, Nodus Nelumbinis Rhizomatis 290-310g, Colla Plastri Testudinis 190-210g, Placenta Hominis 40-60g, Radix Glycyrrhizae 40-60g.
Preferred weight part of each crude drug is: Radix Ginseng 100g, Radix Astragali 100g, Poria 100g, Semen Ziziphi Spinosae (parched) 100g, Radix Paeoniae Alba 100g, Herba Dendrobii 100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 100g, Radix Angelicae Sinensis 100g, Radix Notoginseng 240g, Colla Corii Asini 200g, Fructus Lycii 300g, Radix Rehmanniae Preparata 300g, Radix Rehmanniae 200g, Herba Agrimoniae 200g, Fructus Ligustri Lucidi 300g, Ramulus Cinnamomi 100g, Radix Sanguisorbae 300g, Nodus Nelumbinis Rhizomatis 300g, Colla Plastri Testudinis 200g, Placenta Hominis 50g, Radix Glycyrrhizae 50g.
Wherein said Radix Sanguisorbae is selected Radix Sanguisorbae preparata, and the Radix Rehmanniae is selected the stir-fry Radix Rehmanniae.
The present invention's crude drug used can be bought and obtain from common Chinese shop, and its specification meets national Chinese crude drug standard.
Chinese medicine composition of the present invention can add various adjuvants required while preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., with conventional method of Chinese medicinal, be prepared into any conventional oral formulations, wherein, described oral formulations can be decoction, pill, capsule or tablet.
Another object of the present invention is to provide a kind of method of preparing the present composition, comprises the steps,
1) by prescription weight number, take following each taste crude drug: Radix Ginseng 100g, Radix Astragali 100g, Poria 100g, Semen Ziziphi Spinosae (parched) 100g, Radix Paeoniae Alba 100g, Herba Dendrobii 100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 100g, Radix Angelicae Sinensis 100g, Radix Notoginseng 240g, Colla Corii Asini 200g, Fructus Lycii 300g, Radix Rehmanniae Preparata 300g, Radix Rehmanniae 200g, Herba Agrimoniae 200g, Fructus Ligustri Lucidi 300g, Ramulus Cinnamomi 100g, Radix Sanguisorbae 300g, Nodus Nelumbinis Rhizomatis 300g, Colla Plastri Testudinis 200g, Placenta Hominis 50g, Radix Glycyrrhizae 50g;
2) by above-mentioned each taste material medicine pulverization, mix homogeneously, adds Mel, furnishing ball shape, and high-temperature sterilization, every ball is as Semen phaseoli radiati size, 0.04-0.6g.
Usage and consumption:
The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as age of patient, body weight, health status.
Instruction: pill, adult 40g-60g every day, a minute morning and evening takes after mixing it with water for 2 times; Child 10g-20g every day, a minute morning and evening takes after mixing it with water for 2 times.Within two months, be a course for the treatment of, for stubborn disease, must adhere to taking lastingly, can control.
Pharmacology analysis:
Select Placenta Hominis, Radix Ginseng, the Radix Astragali, Colla Corii Asini, Colla Plastri Testudinis, there is QI invigorating, nourishing blood function;
Select Semen Ziziphi Spinosae, Fructus Lycii, Radix Rehmanniae Preparata, Herba Dendrobii, the Radix Paeoniae Alba, Fructus Ligustri Lucidi, there is YIN nourishing tonify deficiency effect;
Select Ramulus Cinnamomi, Radix Sanguisorbae preparata, Nodus Nelumbinis Rhizomatis, the Radix Rehmanniae, the Pseudobulbus Bletillae (Rhizoma Bletillae), there is powerful hemostasia effect;
Select Mel, be taken at all things on earth elite, have and moisturize the effect of promoting the production of body fluid.
Medicated diet prepared by the present invention has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and treatment disease, and the use link that this medicine is dropped into treatment disease provides science and objective foundation.Its test method and result of the test are as follows respectively:
1. the pill that prepared by couple the present invention carries out animal acute toxicity test:
Medicine: the pill ，You The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine of being prepared by prescription of the present invention provides.
Experimental animal: white mice, body weight is at 30-50g, and male and female select ，You Medical University Of Anhui to provide at random.
Method and result: get 50 of white mice, be divided into 5 groups, 10 every group, hungry about 15 hours, by every each 30g, fill with medicine feed thing, in 24 hours, fill with respectively medicine feed thing 1,2,3,4,5 times, observe 5 days for the 1st, 2,3,4,5 groups, white mice is movable normal, and non-toxic reaction, without dead.Wherein white mice dosage is calculated by kg body weight dose, shows that oral liquid is without acute toxicity, clinical medicine dose safety.
2. the pill that prepared by couple the present invention carries out long-term toxicity test for animals:
Experimental animal: rat, body weight, at 120-130g, all selects male white rat ，You Medical University Of Anhui to provide.
Method and result: get 50 of rat, be divided into 5 groups, every group 10, wherein the 1st, 2, 3, 4 groups as administration group, fill with respectively medicine feed thing 15g for every group, 20g, 30g, 40g, the 5th group of normal feeding as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the variation of tissues observed form, observe the effect of dosage, observe diet, movable variation, experimental results show that administration group and matched group are relatively without significant change, a kind of safe drugs.
3. diagnostic criteria
1) in order to verify clinical efficacy, this prescription is tried out in First Attached Hospital, Anhui Medical Univ. and The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine respectively, and by choosing at random wherein 50 routine adult patients, the course for the treatment of is the shortest is half a year, and what the course for the treatment of was the longest is 2 years.
3) Therapeutic Method
According to drug ratios of the present invention, take raw material (dosage), the foundation conventionally method of preparation obtains pill, and every day, 50g, serviced once sooner or later, and taking 30 days is a course for the treatment of.
4) efficacy determination:
Cure: clinical symptoms sign disappears, it is normal that functional activity recovers, and follows up a case by regular visits to not recurrence in 1 year.
Effective: clinical symptoms sign is clearly better or large portion disappears.
Invalid: bed symptom and sign is without improvement.
Concrete therapeutic outcome is referring to table 1.
Table 1
| Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage (%) |
| 50 | 8 | 25 | 15 | 2 | 96 |
The invention has the beneficial effects as follows: the present invention draws materials easily, makes the features such as simple, with low cost, practicality is good, and taking dose is little, and Harmful ingredient content is low, has no side effect, evident in efficacy.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach object and effect is easy to understand, below in conjunction with specific embodiment, further set forth the present invention.
Embodiment 1
By following weight, take each crude drug: Radix Ginseng 100g, Radix Astragali 100g, Poria 100g, Semen Ziziphi Spinosae (parched) 100g, Radix Paeoniae Alba 100g, Herba Dendrobii 100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 100g, Radix Angelicae Sinensis 100g, Radix Notoginseng 240g, Colla Corii Asini 200g, Fructus Lycii 300g, Radix Rehmanniae Preparata 300g, Radix Rehmanniae 200g, Herba Agrimoniae 200g, Fructus Ligustri Lucidi 300g, Ramulus Cinnamomi 100g, Radix Sanguisorbae 300g, Nodus Nelumbinis Rhizomatis 300g, Colla Plastri Testudinis 200g, Placenta Hominis 50g, Radix Glycyrrhizae 50g;
By above-mentioned each taste material medicine pulverization, mix homogeneously, adds Mel, makes ball shape, high-temperature sterilization, and every ball is as Semen phaseoli radiati size; Adult 40g-60g every day, a minute morning and evening takes after mixing it with water for 2 times; Child 10g-20g every day, a minute morning and evening takes after mixing it with water for 2 times.
Embodiment 2
By following weight, take each crude drug: Radix Ginseng 90g, Radix Astragali 90g, Poria 90g, Semen Ziziphi Spinosae (parched) 90g, Radix Paeoniae Alba 90g, Herba Dendrobii 90g, Pseudobulbus Bletillae (Rhizoma Bletillae) 90g, Radix Angelicae Sinensis 90g, Radix Notoginseng 230g, Colla Corii Asini 190g, Fructus Lycii 290g, Radix Rehmanniae Preparata 290g, Radix Rehmanniae 190g, Herba Agrimoniae 190g, Fructus Ligustri Lucidi 290g, Ramulus Cinnamomi 90g, Radix Sanguisorbae 290g, Nodus Nelumbinis Rhizomatis 290g, Colla Plastri Testudinis 190g, Placenta Hominis 40g, Radix Glycyrrhizae 40g.
By above-mentioned each taste material medicine pulverization, mix homogeneously, adds Mel, makes ball shape, high-temperature sterilization, and every ball is as Semen phaseoli radiati size; Adult 40g-60g every day, a minute morning and evening takes after mixing it with water for 2 times; Child 10g-20g every day, a minute morning and evening takes after mixing it with water for 2 times.
Embodiment 3
By following weight, take each crude drug: Radix Ginseng 110g, Radix Astragali 110g, Poria 110g, Semen Ziziphi Spinosae (parched) 110g, Radix Paeoniae Alba 110g, Herba Dendrobii 110g, Pseudobulbus Bletillae (Rhizoma Bletillae) 110g, Radix Angelicae Sinensis 110g, Radix Notoginseng 250g, Colla Corii Asini 210g, Fructus Lycii 310g, Radix Rehmanniae Preparata 310g, Radix Rehmanniae 210g, Herba Agrimoniae 210g, Fructus Ligustri Lucidi 310g, Ramulus Cinnamomi 110g, Radix Sanguisorbae 310g, Nodus Nelumbinis Rhizomatis 310g, Colla Plastri Testudinis 210g, Placenta Hominis 60g, Radix Glycyrrhizae 60g.
By above-mentioned each taste material medicine pulverization, mix homogeneously, adds Mel, makes ball shape, high-temperature sterilization, and every ball is as Semen phaseoli radiati size; Adult 40g-60g every day, a minute morning and evening takes after mixing it with water for 2 times; Child 10g-20g every day, a minute morning and evening takes after mixing it with water for 2 times.
Model case
Case 1
Understand so-and-so people from Mingguang City of ，Nan ，29Sui， Anhui Province.Before 3 years, Platelet reduces purpura, and through hospitalization effect time, front case is made a definite diagnosis, through the whole bag of tricks, fail to respond to any medical treatment, and platelet 22,100, the side effect of hormone is apparent.By treatment by Chinese herbs of the present invention (Western medicine such as hormone of stopping using) 10 months, now cure completely, through inspections such as regular platelet, all normal.
Case 2
Take so-and-so the Fuyang City people of ，Nv ，38Sui， Anhui Province.Because suffering from idiopathic thrombocytopenic purpura, aplastic anemia, leukopenia, platelet is down to below 13,000, and Syndrome in TCM is shown in: white and thin fur, thready and rapid pulse is string slightly, pale complexion, moon face, the typical hormone side effect sign such as buffalo hump, by treatment by Chinese herbs of the present invention half a year, platelet rises to 21,000.Complexion slightly takes a turn for the better, and adheres to treatment, and after 12 months, platelet rises to more than 180,000, and complexion is good at present, and life freely, uncomfortable without institute, can be normally referring to work.
Case 3
Zheng, female, 24 years old, people from Hefei City, Anhui Province, rescued invalidly in hospital because of acute primary thrombocytopenic purpura disease at the beginning of 2005, and platelet is down to more than 3,000.After take pill of the present invention, adhere to having taken transference cure 6 months; After continue again to take 6 months, cure; Follow up a case by regular visits to not recurrence in a year.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (6)
1. a Chinese medicine composition that is used for the treatment of thrombocytopenia, is characterized in that: the medicament of being made by the crude drug of following weight,
Radix Ginseng 90-110g, Radix Astragali 90-110g, Poria 90-110g, Semen Ziziphi Spinosae (parched) 90-110g, Radix Paeoniae Alba 90-110g, Herba Dendrobii 90-110g, Pseudobulbus Bletillae (Rhizoma Bletillae) 90-110g, Radix Angelicae Sinensis 90-110g, Radix Notoginseng 230-250g, Colla Corii Asini 190-210g, Fructus Lycii 290-310g, Radix Rehmanniae Preparata 290-310g, Radix Rehmanniae 190-210g, Herba Agrimoniae 190-210g, Fructus Ligustri Lucidi 290-310g, Ramulus Cinnamomi 90-110g, Radix Sanguisorbae 290-310g, Nodus Nelumbinis Rhizomatis 290-310g, Colla Plastri Testudinis 190-210g, Placenta Hominis 40-60g, Radix Glycyrrhizae 40-60g.
2. a kind of Chinese medicine composition that is used for the treatment of thrombocytopenia according to claim 1, is characterized in that: the medicament of being made by the crude drug of following weight,
Radix Ginseng 100g, Radix Astragali 100g, Poria 100g, Semen Ziziphi Spinosae (parched) 100g, Radix Paeoniae Alba 100g, Herba Dendrobii 100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 100g, Radix Angelicae Sinensis 100g, Radix Notoginseng 240g, Colla Corii Asini 200g, Fructus Lycii 300g, Radix Rehmanniae Preparata 300g, Radix Rehmanniae 200g, Herba Agrimoniae 200g, Fructus Ligustri Lucidi 300g, Ramulus Cinnamomi 100g, Radix Sanguisorbae 300g, Nodus Nelumbinis Rhizomatis 300g, Colla Plastri Testudinis 200g, Placenta Hominis 50g, Radix Glycyrrhizae 50g.
3. a kind of Chinese medicine composition that is used for the treatment of thrombocytopenia according to claim 1 and 2, is characterized in that: described medicament is any suitable preparation clinically.
4. a kind of Chinese medicine composition that is used for the treatment of thrombocytopenia according to claim 3, is characterized in that: described preparation is oral formulations.
5. a kind of Chinese medicine composition that is used for the treatment of thrombocytopenia according to claim 4, is characterized in that: described oral formulations is pill.
6. the purposes in thrombocytopenia disease drug according to the Chinese medicine composition described in claim 1 or 2 any one.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310488650.0A CN103585471B (en) | 2013-10-18 | 2013-10-18 | Traditional Chinese medicine composition for treating thrombocytopenia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663419A (en) * | 2016-03-25 | 2016-06-15 | 杨忠雅 | Formula for pure traditional Chinese medicines capable of generating new blood, dispelling extravasated blood and treating leukemia |
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|---|---|---|---|---|
| CN1071582A (en) * | 1991-10-12 | 1993-05-05 | 龙孟麟 | Aplastic anemia is converted into leukemia |
| CN1157166A (en) * | 1996-01-25 | 1997-08-20 | 温顺明 | Xuefukang medicine |
| CN1160560A (en) * | 1996-03-21 | 1997-10-01 | 廖柏松 | Chinese patent drug for curing leukopenia and its preparation process |
| CN1181959A (en) * | 1997-07-09 | 1998-05-20 | 迟经惠 | Yin nourishing bolus for curing women's blood deficiency |
| CN1260983A (en) * | 1999-01-21 | 2000-07-26 | 仇殿明 | Process for preparing leukemia medicines |
| CN102210820A (en) * | 2011-05-24 | 2011-10-12 | 姜爱军 | Chinese medicinal composition for treating leukemia |
-
2013
- 2013-10-18 CN CN201310488650.0A patent/CN103585471B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071582A (en) * | 1991-10-12 | 1993-05-05 | 龙孟麟 | Aplastic anemia is converted into leukemia |
| CN1157166A (en) * | 1996-01-25 | 1997-08-20 | 温顺明 | Xuefukang medicine |
| CN1160560A (en) * | 1996-03-21 | 1997-10-01 | 廖柏松 | Chinese patent drug for curing leukopenia and its preparation process |
| CN1181959A (en) * | 1997-07-09 | 1998-05-20 | 迟经惠 | Yin nourishing bolus for curing women's blood deficiency |
| CN1260983A (en) * | 1999-01-21 | 2000-07-26 | 仇殿明 | Process for preparing leukemia medicines |
| CN102210820A (en) * | 2011-05-24 | 2011-10-12 | 姜爱军 | Chinese medicinal composition for treating leukemia |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663419A (en) * | 2016-03-25 | 2016-06-15 | 杨忠雅 | Formula for pure traditional Chinese medicines capable of generating new blood, dispelling extravasated blood and treating leukemia |
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