CN101502583A - Chinese medicament preparation for treating cholecystitis and gall-stone as well as preparation method thereof - Google Patents
Chinese medicament preparation for treating cholecystitis and gall-stone as well as preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating cholecystitis and gallstones and a preparation method thereof. The main pharmaceutical raw materials and the proportioning by weight are as follows: 18-80 parts of Szechuan lovage rhizome, 18-80 parts of Chinese thorowax, 18-80 parts of costus root, 28-140 parts of yellow croaker ear-stone, 18-80 parts of immature bitter orange, 18-80 parts of officinal magnolia bark, 28-140 parts of Chinese angelica, 18-80 parts of golden thread and 18-80 parts of liquoric root. The preparation method comprises: 1. medicinal materials are washed, wherein, the Chinese angelica is processed with wine, and the yellow croaker ear-stone is calcined; 2. the yellow croaker ear-stone is dried and smashed into medicine powder; 3. the other medicinal materials are dried and smashed into the medicine powder, water is added for soaking, filtrate generated by two times of decoction is merged, an extract is obtained, and the extract is concentrated to thick paste which is further smashed; 4. the medicine powder of the step 2 and the step 3 is mixed; 5. excipients are added for preparing capsules, tablets and so on. The traditional Chinese medicine preparation has significant therapeutic and analgesic effects for cholecystitis and gallstones, obvious efficacy, short treatment cycle and low recurrence rate.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, specifically refer to a kind of Chinese medicine preparation for the treatment of calculus in cholecystitis, the gallbladder and preparation method thereof.
Background technology:
Though cholecystitis, cholelithiasis can not jeopardize people's life immediately, and be very big to people's healthy influence, according to recent statistics, present domestic cholecystitis, cholelithiasis sickness rate are in rising trend.Press the Chinese medical discrimination theory, the main etiology and pathogenesis of cholecystitis, cholelithiasis is QI stagnation of the liver and galibladder, evil poly-gallbladder internal organs, gallbladder internal organs obstinate disease, damp and hot retardance, the living poison of heat-transformation, the rotten wound of pyretic toxicity, cholestasis, the long-pending stone that forms, treatment should reach the purpose for the treatment of both the principal and the secondary aspects of a disease at the same time with heat-clearing and toxic substances removing, depressed liver-energy dispersing and function of gallbladder promoting, pure and impure, knot, function of gallbladder promoting repercussive, the circulation of qi promoting calculus of disappearing of regulating the flow of vital energy of purging FU-organs.Also use the Chinese medicine of some treatment cholecystitis, cholelithiasis in the market, but mostly a side is laid particular stress in the treatment of cholecystitis and cholelithiasis, be difficult to take into account, and therapeutic effect is not obvious, the cycle is long.
Summary of the invention:
The object of the present invention is to provide and a kind ofly can rule together the Chinese medicine preparation that therapeutic effect is obvious, the cycle is short and relapse rate is low cholecystitis and cholelithiasis.Another object of the present invention is to provide a kind of preparation method for the treatment of cholecystitis, cholelithiasis Chinese medicine preparation.
The object of the present invention is achieved like this, its primary raw material medicine and weight proportion are as follows:
18～80 parts of Rhizoma Chuanxiongs, 18～80 parts of Radix Bupleuri, 18～80 parts of Radix Aucklandiae (Radix Vladimiriae), 28～140 parts of Asteriscus Pseudosciaenaes, 18～80 parts of Fructus Aurantii Immaturuss, 18～80 parts of Cortex Magnoliae Officinalis, 28～140 parts of Radix Angelicae Sinensis, 18～80 parts of Rhizoma Coptidis, 18～80 parts in Radix Glycyrrhizae.
Optimum weight proportioning of the present invention is as follows:
60 parts of Rhizoma Chuanxiongs, 60 parts of Radix Bupleuri, 60 parts of Radix Aucklandiae (Radix Vladimiriae), 100 parts of Asteriscus Pseudosciaenaes, 60 parts of Fructus Aurantii Immaturuss, 60 parts of Cortex Magnoliae Officinalis, 100 parts of Radix Angelicae Sinensis, 60 parts of Rhizoma Coptidis, 60 parts in Radix Glycyrrhizae.
The present invention also comprises one of following crude drug or its combination: 28～140 parts of the Radix Paeoniae Albas, 18～80 parts of the Rhizoma Atractylodis Macrocephalaes, 28～140 parts of rhizoma sparganic, 18～80 parts of Rhizoma Curcumae, 18～80 parts of RADIX CURCUMAE from Sichuan of China, 18～80 parts of Rhizoma Atractylodis, 18～80 parts of Fructus Toosendan, 28～140 parts of Concha Arcaes, 28～140 parts of Herba Lysimachiaes, 12～80 parts of Radix Et Rhizoma Rhei, 28～140 parts in Talcum, 18～80 parts of Fructus Evodiaes, 18～80 parts of Pericarpium Citri Reticulataes.
Be the monarch drug group with Rhizoma Chuanxiong, Radix Bupleuri, Radix Aucklandiae (Radix Vladimiriae), Asteriscus Pseudosciaenae, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae in the side, Rhizoma Chuanxiong suffering, temperature, return the liver and gall warp, blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, to the effect of having clear improvement of liver and gall microcirculation, obvious renal blood flow increasing, and remarkable diuresis is arranged.Radix Bupleuri induces sweat and brings down a fever, and dispersing the stagnated live-QI to relieve the stagnation of QI has antiinflammatory, antiviral and analgesic activity, and staphylococcus aureus, vaccinia virus, epidemic haemorrhagic fever virus are had inhibitory action, liver is had the effect of significant protective effect and promotion bile secretion.The Radix Aucklandiae (Radix Vladimiriae) promoting the circulation of QI to relieve pain, intestinal stasis relieving in the accent has tangible antiinflammatory and choleretic effect, and the mice foot swelling that the mouse ear that xylol causes is swollen, carrageenin causes has inhibitory action.Asteriscus Pseudosciaenae has that fossil is treating stranguria, the effect of heat-clearing and toxic substances removing, and cholelithiasis is had the eliminating effect.Radix Paeoniae Alba relieving spasm to stop pain, the yin fluid astringing suppressing the hyperactive liver protects the liver and Detoxication, and Radix Paeoniae Alba total glucosides has obvious inhibitory action to the rat experiment adjuvant-induced arthritis, and staphylococcus aureus, blood dissolubility streptococcus, Bacillus proteus etc. are all had different inhibitory action, has a broad antifungal spectrum.Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI has significant protective effect to hepatic injury, and above-mentioned six medicines are the monarch drug group, heat-clearing and toxic substances removing, and depressed liver-energy dispersing and function of gallbladder promoting, fossil is treating stranguria, and living Qinghua is turbid.
With Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Rhizoma Curcumae, RADIX CURCUMAE from Sichuan of China, Rhizoma Atractylodis is the ministerial drug group.Fructus Aurantii Immaturus dispelling the stagnated QI removing food stagnancy has significantly antibacterial, antiinflammatory, antivirus action, and the pedal swelling that PARA FORMALDEHYDE PRILLS(91,95) pedal swelling and carrageenin cause has the obvious suppression effect.Cortex Magnoliae Officinalis circulation of qi promoting intestinal stasis relieving has antiinflammatory, resisting pathogenic microbes effect, and immunological liver fibrosis and liver cirrhosis are prevented effect, and staphylococcus, anthrax bacillus etc. is had antibacterial action, and Streptococcus mutans is had efficient quick sterilization effect.The Radix Angelicae Sinensis promoting blood circulation and stopping pain can increase the excretion of solids and cholic acid in the bile.Rhizoma Curcumae is returned the liver spleen channel, and tangible antiinflammatory and hepatoprotective effect are arranged, and mice ear inflammation and cotton balls granulation bacterium that Oleum Tiglii is caused have obvious inhibitory action.The RADIX CURCUMAE from Sichuan of China blood circulation promoting and blood stasis dispelling, promoting QI circulation for relieving depression have protective effect to hepatic injury.Rhizoma Atractylodis are drying damp and strengthening spleen, and gastrointestinal is had regulating action.More than six medicines be the ministerial drug group, antiinflammatory, antiviral, antimicrobial, activating blood circulation to dissipate blood stasis, hepatic cholagogic, purging FU-organs is pure and impure.
Assistant is with Rhizoma Coptidis, Fructus Toosendan, Concha Arcae, rhizoma sparganic, Herba Lysimachiae, Radix Et Rhizoma Rhei, Talcum.Rhizoma Coptidis clearing away heat-fire, dampness detoxifcation have antiinflammatory, antiviral, anti-microbial effect.Fructus Toosendan is returned liver stomach-intestinal warp, soothing the liver expelling the heat-evil, promoting the circulation of QI to relieve pain.Concha Arcae has the effect of expectorant blood stasis dispelling, hard masses softening and resolving.The circulation of qi promoting of rhizoma sparganic removing blood stasis, the removing food stagnancy pain relieving has the contraction of the intestinal tube of promotion, forms, reduces the whole blood viscosity effect by antithrombotic, helps the liver and gall microcirculation, and can obviously reduce the writhing response number of times that mice causes because of the acetic acid stimulation.The Herba Lysimachiae heat clearing and inflammation relieving, inducing diuresis for treating stranguria syndrome has the effect of the calculus of discharge.Radix Et Rhizoma Rhei, attack stagnant, clearing away damp-heat, blood stasis dispelling detoxifcation has detoxifcation and choleretic effect.Talcum, inducing diuresis for treating stranguria syndrome, heat clearing and blood circulation promoting.More than seven flavors for the adjuvant drug group, heat clearing and blood stasis dispersing, the knot that disappears of regulating the flow of vital energy, hard masses softening and resolving, relieving spasm to stop pain.
With Fructus Evodiae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae is the messenger drug group.The Fructus Evodiae warming spleen and stomach for dispelling cold, the soothing the liver therapeutic method to keep the adverse QI flowing downwards has digestion promoting function.During Pericarpium Citri Reticulatae is regulated the flow of vital energy and transferred, but the intestinal tube pneumatosis is discharged in the secretion of facilitating digestion liquid.The Radix Glycyrrhizae heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription has and has slow.More than three flavors for the messenger drug group, the spleen invigorating of being good for the stomach, integration one, the function of gallbladder promoting repercussive improves curative effect.
The preparation method of above-mentioned treatment cholecystitis, cholelithiasis Chinese medicine preparation may further comprise the steps: 1, earlier medical material is washed, wherein ought be classified as Radix Angelicae Sinensis (processed with wine), Radix Et Rhizoma Rhei is the wine Radix Et Rhizoma Rhei, adopts the pressure sintering processed with wine, and Asteriscus Pseudosciaenae is calcine with high heat, and Concha Arcae is a Concha Arcae (calcined); 2, will be crushed to 100～200 orders after Asteriscus Pseudosciaenae, Concha Arcae, the Talcum oven dry, medicated powder is standby; 3, with other medical material natural drying or oven dry, pulverizing is 100～200 order medicated powder, and mix homogeneously, puts into extractor, soaks 3 hours, decocts 2.5 hours～3 hours for the first time, leaches; Decocted 1.5 hours～2 hours for the second time, leach; Twice filtrate is merged, get activity extract, stir, it is 1.30～1.35 thick paste shapes that filtrate is condensed into density, and oven dry, pulverizing are 100～200 order medicated powder; 4, with the abundant mix homogeneously of medicated powder of step " 2 ", step " 3 ", get powder; 5. powder is added right amount of auxiliary materials, make capsule, tablet, granule, drop pill or enteric coated tablet with common process.
Adjuvant is meant filler, lubricant.Filler comprises one or more in solvable or microsolubility calcium salt, mannitol, starch, dextrin, the microcrystalline Cellulose.Lubricant comprises one or more in micropowder silica gel, the magnesium stearate.
The clinical trial of Chinese medicine preparation of the present invention, pharmacodynamics and toxicity study result of the test are as follows:
Clinical test results: the present invention is example through clinical practice for many years with the patient treatment of 133 examples being suffered from cholecystitis, cholelithiasis.Male's 82 examples wherein, women's 51 examples.Gallbladder enlargement 55 examples, the coarse and extrahepatic duct of gallbladder wall dwindles 40 examples, cholelithiasis 30 examples, silt particle shape cholelithiasis 8 examples.By blood routine examination, the B ultrasonic imaging examination is taken medicine one more than the course of treatment, and two months is a course of treatment, and 99% conditions of patients has in various degree and alleviates.Wherein gallbladder enlargement patient 94% cures fully, and all the other 6% patients take a turn for the better.Coarse and the extrahepatic duct of gallbladder wall dwindles 92% cures, and 8% takes a turn for the better.Cholelithiasis 63% is cured, and 37% takes a turn for the better.Silt particle shape cholelithiasis 63% is cured, and 25% takes a turn for the better, 12% keep stable.Specifically see Table 1, table 2:
Table 1: cholecystitis treatment situation
| Name of disease | The example number | Alleviate fully | Part is alleviated | Stable | Worsen |
| The gallbladder enlargement | 55 | 52 | 3 | 0 | 0 |
| Coarse and the extrahepatic duct of gallbladder wall dwindles | 40 | 37 | 3 | 0 | 0 |
Efficacy assessment standard:
Alleviate fully: gallbladder enlargement complete obiteration, keep more than 4 weeks;
Part is alleviated: the gallbladder enlargement is dwindled more than 50%, keeps for 4 weeks;
Stable: the gallbladder enlargement is dwindled not as good as 50%, increases to be no more than 25%;
Worsen: gallbladder increases more than 25%.
Table 2 cholelithiasis treatment situation
| Name of disease | The example number | Alleviate fully | Part is alleviated | Stable | Worsen |
| Cholelithiasis | 30 | 19 | 11 | 0 | 0 |
| Silt particle shape cholelithiasis | 8 | 5 | 2 | 1 | 0 |
Efficacy assessment standard:
Alleviate fully: the calculus complete obiteration, keep more than 4 weeks;
Part is alleviated: calculus is dwindled more than 50%, keeps for 4 weeks;
Stable: calculus is dwindled not as good as 50%, increases to be no more than 25%;
Worsen: calculus increases more than 25%.
The main pharmacodynamics result:
1, to the effect of rat bile
Test shows that Chinese medicine preparation of the present invention has stronger choleretic effect.Increase the rat bile flow significantly, reduce cholesterol level (P＜0.005), reduce total bilirubin content (P＜0.05) in the serum, showing has choleretic effect.
2, antiinflammatory action
Chinese medicine preparation capsule Dichlorodiphenyl Acetate of the present invention causes rat paw edema antiinflammatory action.Xylol causes mice ear, tries one's best to mouse stomach with this Chinese medicine preparation of concentration 1.8g/kg, and its swelling degree is lower than danshitong capsules matched group (P＜0.05).Show that this Chinese medicine preparation xylol causes mice ear good inhibitory effect is arranged.
3, bacteriostasis
Show that through the extracorporeal bacteria inhibitor test test result Chinese medicine preparation of the present invention has strong inhibitory action to staphylococcus aureus, escherichia coli, dysentery bacterium.In vivo test shows that the Radix Paeoniae Alba, Cortex Magnoliae Officinalis all have inhibitory action to staphylococcus aureus, escherichia coli, dysentery bacterium etc.
4, analgesic activity
The mouse writhing influence that table 3 gallbladder disease Chinese medicine preparation Dichlorodiphenyl Acetate causes
Annotate: compare with matched group,
*P＜0.05,
*P＜0.01
It is 59.2% (P＜0.05) that the body suppression ratio is turned round in the paroxysmal pain effect that this Chinese medicine preparation causes because of acetic acid mice, shows that Chinese medicine preparation of the present invention has certain analgesic activity.
5, to the protective effect of mouse liver injury.
The influence of the every index of chmice acute hepatic injury that table 4 pair D-galactosamine duplicates
| The normal control group | Model control group | Low dose of (1.375g/kg) | Middle dosage (2.750g/kg) | Heavy dose of (5.500g/kg) | |
| Body weight | 21.30±1.14 | 21.25±1.11 | 21.34±1.32 | 21.72±0.97 | 21.92±1.14 |
| The liver coefficient | 4.28±0.16 | 4.74±0.31 | 4.68±0.42 | 4.59±0.46 | 4.87±0.18 |
| The spleen coefficient | 0.48±0.11 | 0.50±0.11 | 0.42±0.006 | 0.43±0.087 | 0.46±0.07 |
| ALT | 6.02±33.57 | 86.44±60.44 | 87.71±28.85 | 85.79±48.13 | 30.21±42.20 ** |
| AST | 116.62±18.00 | 148.18±12.99 | 136.06±11.31 * | 145.73±10.71 | 128.77±16.46 ** |
Annotate: 1. number of animals: 10 of normal control groups, 15 of model control group, low dose of 11,11 of middle dosage, heavy dose of 11.
2. compare with model control group
*P＜0.05,
*P＜0.01.
As can be seen from the table, model control group and normal control group relatively, ALT, AST all have obviously and increase, and show that Chinese medicine preparation of the present invention has significant protective effect to hepatic injury.
The toxicity study result of the test:
Table 5 gallbladder disease Chinese medicine preparation The acute toxicity tests
Compare with matched group,
*P〉0.05
As can be seen from the table, the toxicity of this Chinese medicine preparation, give mouse stomach with Cmax, maximum volume, animal dead does not all appear, one day accumulative total dosage (maximum dosage-feeding) reach 30g/kg, be equivalent to be grown up 210 times of clinical consumption of 70kg by kg body weight conversion, observed the animal no abnormality seen continuously 7 days.The result shows it is safe.
More than every data show that monarch of the present invention, minister, help, make and respectively execute its effect, liver and gall are transferred mutually, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, heat-clearing and toxic substances removing, depressed liver-energy dispersing and function of gallbladder promoting, pure and impure, knot, promoting digestion and protecting liver, the sharp intestinal diuresis of disappearing of regulating the flow of vital energy of purging FU-organs effectively increase bile secretion, improve immunity.Cholecystitis, cholelithiasis are had obvious therapeutic action and analgesic activity, and cholecystitis, cholelithiasis are ruled together, and effect is obvious, treatment cycle is short and relapse rate is low.After general patient takes medicine, all can in two months, eliminate symptom, get well.This Chinese medicine preparation does not have toxic and side effects to human body.
The specific embodiment:
Embodiment 1: get 60 parts of Rhizoma Chuanxiongs, 60 parts of Radix Bupleuri, 60 parts of Radix Aucklandiae (Radix Vladimiriae), 100 parts of Asteriscus Pseudosciaenaes, 60 parts of Fructus Aurantii Immaturuss, 60 parts of Cortex Magnoliae Officinalis, 100 parts of Radix Angelicae Sinensis, 60 parts of Rhizoma Coptidis, 60 parts in Radix Glycyrrhizae.Earlier medical material is washed, wherein Asteriscus Pseudosciaenae is crushed to 100～200 order medicated powder behind the calcine with high heat.Other medical material natural drying or oven dry, pulverizing are 100～200 order medicated powder, put into extractor, extract twice, get the filtrate extract, it is 1.30～1.35 thick paste shapes that filtrate is condensed into density, and oven dry, pulverizing are 100～200 order medicated powder, with the abundant mix homogeneously of Asteriscus Pseudosciaenae medicated powder, get powder, disinfect.Or powder added appropriate amount of auxiliary materials, make capsule with common process.Every 0.5 gram, usage is every day 2 times, each 4, one after each meal, plain boiled water is taken after mixing it with water.
Embodiment 2: get 18 parts of Rhizoma Chuanxiongs, 18 parts of Radix Bupleuri, 18 parts of Radix Aucklandiae (Radix Vladimiriae), 28 parts of Asteriscus Pseudosciaenaes, 18 parts of Rhizoma Curcumae, 28 parts of Concha Arcaes, 18 parts of Fructus Aurantii Immaturuss, 28 parts of Radix Angelicae Sinensis, 18 parts of RADIX CURCUMAE from Sichuan of China, 28 parts of the Radix Paeoniae Albas, 18 parts of Rhizoma Coptidis, 18 parts of the Rhizoma Atractylodis Macrocephalaes, 18 parts of Cortex Magnoliae Officinalis, 28 parts of rhizoma sparganic, 18 parts of Fructus Toosendan, 18 parts of Rhizoma Atractylodis, 18 parts of Pericarpium Citri Reticulataes, 18 parts of Fructus Evodiaes, 28 parts in Talcum, 18 parts in Radix Glycyrrhizae.Earlier medical material is washed, Asteriscus Pseudosciaenae calcine with high heat wherein, Concha Arcae is a Concha Arcae (calcined).To be crushed to 100～200 order medicated powder after Asteriscus Pseudosciaenae, Concha Arcae, the Talcum oven dry.Other medical material natural drying or oven dry, pulverizing is 100～200 order medicated powder, put into extractor, extract twice, get the filtrate extract, it is 1.30～1.35 thick paste shapes that filtrate is condensed into density, oven dry, pulverizing are 100～200 order medicated powder, with Asteriscus Pseudosciaenae, Concha Arcae, the abundant mix homogeneously of Talcum medicated powder, get powder, disinfect.Or powder added appropriate amount of auxiliary materials, make capsule with common process.Every 0.5 gram, usage is every day 2 times, each 4, one after each meal, plain boiled water is taken after mixing it with water.
Embodiment 3: get 80 parts of Rhizoma Chuanxiongs, 80 parts of Radix Bupleuri, 80 parts of Radix Aucklandiae (Radix Vladimiriae), 140 parts of Radix Angelicae Sinensis, 80 parts of Fructus Aurantii Immaturuss, 80 parts of Rhizoma Coptidis, 80 parts of Cortex Magnoliae Officinalis, 80 parts of Fructus Toosendan, 140 parts of Asteriscus Pseudosciaenaes, 80 parts of Rhizoma Atractylodis, 140 parts of the Radix Paeoniae Albas, 80 parts of the Rhizoma Atractylodis Macrocephalaes, 140 parts of rhizoma sparganic, 80 parts of Rhizoma Curcumae, 80 parts of RADIX CURCUMAE from Sichuan of China, 140 parts of Concha Arcaes, 140 parts of Herba Lysimachiaes, 80 parts of Radix Et Rhizoma Rhei, 140 parts in Talcum, 80 parts of Fructus Evodiaes, 80 parts of Pericarpium Citri Reticulataes, 80 parts in Radix Glycyrrhizae.Earlier medical material is washed, wherein ought be classified as Radix Angelicae Sinensis (processed with wine), Radix Et Rhizoma Rhei is the wine Radix Et Rhizoma Rhei, adopts the pressure sintering processed with wine, and Asteriscus Pseudosciaenae is calcine with high heat, and Concha Arcae is a Concha Arcae (calcined).To be crushed to 100～200 order medicated powder after Asteriscus Pseudosciaenae, Concha Arcae, the Talcum oven dry.Other medical material natural drying or oven dry, pulverizing is 100～200 order medicated powder, put into extractor, extract twice, get the filtrate extract, it is 1.30～1.35 thick paste shapes that filtrate is condensed into density, oven dry, pulverizing are 100～200 order medicated powder, with Asteriscus Pseudosciaenae, Concha Arcae, the abundant mix homogeneously of Talcum medicated powder, get powder, disinfect.Or powder added appropriate amount of auxiliary materials, make capsule with common process.Every 0.5 gram, usage is every day 2 times, each 4, one after each meal, plain boiled water is taken after mixing it with water.
Concrete case
1,51 years old intermittent pain of right flank of patient man, outbreak about 10 years, loses weight repeatedly, and spirit is often sleepy.Blood routine examination is normal, and liver function test is normal, and the B ultrasonic imaging examination finds that gallbladder increases, and cyst wall thickens, coarse, the thick 2.5mm of cyst wall.Repeatedly treatment is not healed.After taking medicine 2 months, gallbladder is normal, the pain complete obiteration.
2,38 years old long-term pain of gallbladder internal organs of patient woman, accompany abdominal distention, feel sick, detest oil, blood routine examination is normal, and liver function is normal, the B ultrasonic imaging examination is found the long 7.3cm of gallbladder, anteroposterior diameter 5.2cm, 2 the shadow companion of high light group long sound shadows far away of visible 1.3cm * 1.8cm size in the gallbladder wall thickness 3mm, gallbladder, gallbladder wall is coarse to be thickened, after taking medicine 2 months, high light group shadow disappears in the B ultrasonic check capsule, and gallbladder is normal.
3, the right rib pain of patient man patient's readme in 48 years old is nearly 7 years, and abdominal distention, health are become thin, and feed is detested greasy, ultrasound diagnosis, and gallbladder wall is coarse, and the high light group of the association shadow about tens of pieces of 3mm * 4.2mm is arranged in the gallbladder, hospital's suggestion gallbladder removal.After taking medicine 2 months, ultrasound diagnosis, high light group shadow reduces, and checks after continuing to take medicine 1 month, and high light group shadow disappears, and it is normal that gallbladder recovers.
Claims (5)
1. Chinese medicine preparation for the treatment of cholecystitis, cholelithiasis, it is characterized in that: its primary raw material medicine and weight proportion are as follows: 18～80 parts of Rhizoma Chuanxiongs, 18～80 parts of Radix Bupleuri, 18～80 parts of Radix Aucklandiae (Radix Vladimiriae), 28～140 parts of Asteriscus Pseudosciaenaes, 18～80 parts of Fructus Aurantii Immaturuss, 18～80 parts of Cortex Magnoliae Officinalis, 28～140 parts of Radix Angelicae Sinensis, 18～80 parts of Rhizoma Coptidis, 18～80 parts in Radix Glycyrrhizae.
2. the Chinese medicine preparation of treatment cholecystitis according to claim 1, cholelithiasis is characterized in that: its crude drug and weight ratio are as follows: 60 parts of Rhizoma Chuanxiongs, 60 parts of Radix Bupleuri, 60 parts of Radix Aucklandiae (Radix Vladimiriae), 100 parts of Asteriscus Pseudosciaenaes, 60 parts of Fructus Aurantii Immaturuss, 60 parts of Cortex Magnoliae Officinalis, 100 parts of Radix Angelicae Sinensis, 60 parts of Rhizoma Coptidis, 60 parts in Radix Glycyrrhizae.
3. the Chinese medicine preparation of treatment cholecystitis according to claim 1, cholelithiasis is characterized in that: also comprise one of following crude drug or its combination: 28～140 parts of the Radix Paeoniae Albas, 18～80 parts of the Rhizoma Atractylodis Macrocephalaes, 28～140 parts of rhizoma sparganic, 18～80 parts of Rhizoma Curcumae, 18～80 parts of RADIX CURCUMAE from Sichuan of China, 18～80 parts of Rhizoma Atractylodis, 18～80 parts of Fructus Toosendan, 28～140 parts of Concha Arcaes, 28～140 parts of Herba Lysimachiaes, 12～80 parts of Radix Et Rhizoma Rhei, 28～140 parts in Talcum, 18～80 parts of Fructus Evodiaes, 18～80 parts of Pericarpium Citri Reticulataes.
4. according to the Chinese medicine preparation of claim 1 or 3 described treatment cholecystitis, cholelithiasis, it is characterized in that: it is capsule, tablet, granule, drop pill or enteric coated tablet.
5. the preparation method as treatment cholecystitis, cholelithiasis Chinese medicine preparation as described in the claim 3 is characterized in that: comprise the steps: 1, earlier medical material washed that wherein ought be classified as Radix Angelicae Sinensis (processed with wine), Radix Et Rhizoma Rhei is the wine Radix Et Rhizoma Rhei, adopts the pressure sintering processed with wine.Asteriscus Pseudosciaenae is calcine with high heat, and Concha Arcae is a Concha Arcae (calcined); 2, will be crushed to 100～200 orders after Asteriscus Pseudosciaenae, Concha Arcae, the Talcum oven dry, medicated powder is standby; 3, with other medical material natural drying or oven dry, pulverizing is 100～200 order medicated powder, and mix homogeneously, puts into extractor, soaks 3 hours, decocts 2.5 hours～3 hours for the first time, leaches; Decocted 1.5 hours～2 hours for the second time, leach; Twice filtrate is merged, get activity extract, stir, it is 1.30～1.35 thick paste shapes that filtrate is condensed into density, and oven dry, pulverizing are 100～200 order medicated powder; 4, with the abundant mix homogeneously of medicated powder of step " 2 ", step " 3 ", get powder; 5. powder is added right amount of auxiliary materials, make capsule, tablet, granule, drop pill or enteric coated tablet with common process.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491366A (en) * | 2014-12-24 | 2015-04-08 | 张冬 | Traditional Chinese medicine granule preparation for treating hepatic calculus and preparation method thereof |
| CN104800348A (en) * | 2015-04-10 | 2015-07-29 | 王红垒 | Traditional Chinese medicine for treating chronic cholecystitis |
| CN111603545A (en) * | 2020-06-30 | 2020-09-01 | 王悦阳 | Traditional Chinese medicine composition for treating gallstones and preparation method thereof |
-
2009
- 2009-03-09 CN CN200910042810A patent/CN100579544C/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491366A (en) * | 2014-12-24 | 2015-04-08 | 张冬 | Traditional Chinese medicine granule preparation for treating hepatic calculus and preparation method thereof |
| CN104800348A (en) * | 2015-04-10 | 2015-07-29 | 王红垒 | Traditional Chinese medicine for treating chronic cholecystitis |
| CN111603545A (en) * | 2020-06-30 | 2020-09-01 | 王悦阳 | Traditional Chinese medicine composition for treating gallstones and preparation method thereof |
| CN111603545B (en) * | 2020-06-30 | 2022-01-07 | 王悦阳 | Traditional Chinese medicine composition for treating gallstones and preparation method thereof |
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| Publication number | Publication date |
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| CN100579544C (en) | 2010-01-13 |
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