CN104758346A - Medicine for treating migraine, as well as preparation method and preparation of medicine - Google Patents

Medicine for treating migraine, as well as preparation method and preparation of medicine Download PDF

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CN104758346A
CN104758346A CN201510197036.8A CN201510197036A CN104758346A CN 104758346 A CN104758346 A CN 104758346A CN 201510197036 A CN201510197036 A CN 201510197036A CN 104758346 A CN104758346 A CN 104758346A
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parts
medicine
preparation
pain
radix
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邵勇
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Abstract

The invention provides a medicine for treating migraine. The medicine is characterized in by comprising the following ingredients in parts by mass: 8-16 parts of ligusticum wallichii, 8-15 parts of radix angelicae dahuricae, 1-6 parts of wild ginger, 3-10 parts of scorpions, 3-10 parts of centipedes, 10-20 parts of radix puerariae and 2-10 parts of radix glycyrrhizae preparata. The medicine is scientific and ingenious in formula; in accordance with an assistant and guide theory of the traditional Chinese medicines, the ingredients are combined together, so that a significant synergetic enhancement effect is exerted; the medicine has the effects of significantly reducing pain attack times and pain degree, can exert a good effect on migraine prevention after applied for a long time, has little side effect, and cannot cause discomfort to a patient taking the medicine for a long time.

Description

One treats migrainous medicine and preparation method thereof, preparation
Technical field
The present invention relates to the field of Chinese medicines, treat migrainous medicine and preparation method thereof and the preparation that is prepared from of medicine thus in particular to a kind of.
Background technology
Migraine is the Major Clinical feature of the Neurology Department common disease of a kind of recurrent exerbation, serious harm human health, this disease: pain gesture is very acute, or attacks punching and have a pain, or pain as being stabbed, or connect and order tooth, accompany dizzy photophobia, gastral cavity uncomfortable in chest is swollen, nausea and vomiting, being irritable and getting angry easily, recurrent exerbation etc. are principal character.China is one of district occurred frequently of migraine disease, and its high prevalence and disability rate have an immense impact on to social economy and individual.Common disease sorts by life-span loss in year by the World Health Report of WHO issue in 2012, and migraine ranks the 7th, and China's Epidemiological study data display migraine annual loading is 9.3%.Be one or both sides pain during migraine, often accompany nausea and vomiting.Therefore, medicine is more safely and effectively needed to be used for the treatment of migraine.
Its medication effect is still not satisfactory at present.Ergotamine preparation is still the key agents of migraine acute stages treated.Ergotamine shrinks arteria coronaria, peripheral vessels and the effect of hastening parturition because of it, forbids in coronary heart disease, peripheral angiopathy and gravid woman.Qu Putan class medicine is due to comparatively Ergotamine side effect and have obvious curative effects and be widely used, and Qu Putan class medicine is because also there being contraction to arteria coronaria, and price, therefore limit its clinical practice.YANSUAN FUGUILIQIN JIAONANG also has some side reactions, as dizzy, drowsiness, body weight increase, extrapyramidal symptoms etc. as the migrainous line prophylactic treatment medicine for the treatment of.
In view of this, special proposition the present invention.
Summary of the invention
The first object of the present invention is to provide one to treat migrainous medicine, scientific formulation is exquisite, theoretical according to traditional Chinese medical science monarch, each component compatibility together, played significant collaborative reinforced effects, have the effect of significantly ease the pain attack times and pain degree, long-term utilization can be achieved good results to prevention of migraine, and side effect is little, patient's long-term taking can not cause discomfort.
The second object of the present invention is the preparation method providing a kind of described treatment migraine remedy, and the method preparation technology is simple, and cost is low.Scolopendra, Scorpio are prepared into ultramicro powder and are used as medicine, and make the utilization rate of effective ingredient up to more than 90%.Remaining medicine decocts through 2 times, can the effective ingredient of each component of high efficiency extraction, promotes that each component plays significant synergistic function.
The third object of the present invention is the preparation providing a kind of described treatment migraine remedy to be prepared from, and side effect is little, rapid-action, evident in efficacy, patient can according to self need select dosage form, easy to use.
In order to realize above-mentioned purpose of the present invention, spy by the following technical solutions:
One treats migrainous medicine, in mass parts, comprises following component: Rhizoma Chuanxiong 8 ~ 16 parts, the Radix Angelicae Dahuricae 8 ~ 15 parts, Herba Asari 1 ~ 6 part, Scorpio 3 ~ 10 parts, Scolopendra 3 ~ 10 parts, Radix Puerariae 10 ~ 20 parts and Radix Glycyrrhizae Preparata 2 ~ 10 parts.
One provided by the invention treats migrainous medicine, scientific formulation is exquisite, theoretical according to traditional Chinese medical science monarch, each component compatibility together, played significant collaborative reinforced effects, have the effect of significantly ease the pain attack times and pain degree, long-term utilization can be achieved good results to prevention of migraine, and side effect is little, patient's long-term taking can not cause discomfort.
Specifically, the combinatorial principle of formula of the present invention is as follows:
Monarch drug is Rhizoma Chuanxiong, and its pungent temperature enters Liver Channel, and be the gas medicine in blood, promoting flow of QI and blood pain relieving, for controlling the key medicine of headache.
Ministerial drug is the Radix Angelicae Dahuricae, Herba Asari, Scolopendra and Scorpio.The Radix Angelicae Dahuricae: warm in nature, has the effect of the inducing menstruation to relieve menalgia that dispels the wind, and reaches on its medicine temperature is logical, pungently alters away head, assists Rhizoma Chuanxiong to invigorate blood circulation dispersing cold for relieving pain.Herba Asari: acrid in the mouth, temperature.Function cures mainly dispels the wind, cold expelling, and row water, has one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.Scolopendra: salty in the mouth, warm in nature, poisonous, returns Liver Channel.There is effect of endogenous wind stopping relieving convulsion, detoxicating and resolving stagnation of pathogens, removing obstruction in the collateral to relieve pain.Scorpio: acrid in the mouth, property is put down, and returns Liver Channel.Expelling wind and relieving convulsion, removing obstruction in the collateral to relieve pain.The Radix Angelicae Dahuricae, Herba Asari match, and share and can reach expelling wind and cold, blood circulation and channel invigorating, the effect of removing obstruction in the collateral to relieve pain.Coordinate with Scorpio, Scolopendra two medicine again, the auxiliary monarch drug of energy strengthens the merit of pain relieving.
Adjuvant drug is Radix Puerariae.Its sweet in the mouth, pungent, property is put down, and returns spleen, stomach, lung, urinary bladder channel.Yang invigorating expelling pathogenic factors from muscles, effect of removing obstruction in the collateral to relieve pain.Make flavour of a drug Radix Glycyrrhizae Preparata.Its nature and flavor is sweet flat, GUIXIN, lung, spleen, stomach warp.There is the merit of invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relieving spasm to stop pain, the mitigation property of medicine.Adjuvant drug and medicine and all medicines are share, function coordinating the actions of various ingredients in a prescription, relieving spasm to stop pain.
Each amounts of components in prescription of the present invention is also through scientific matching, ingredients complements each other, synergism is there is between various active component, preferably, in mass parts, comprise following component: Rhizoma Chuanxiong 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 14 parts, Herba Asari 3 ~ 6 parts, Scorpio 4 ~ 8 parts, Scolopendra 4 ~ 8 parts, Radix Puerariae 10 ~ 20 parts and Radix Glycyrrhizae Preparata 2 ~ 10 parts.
Further preferably, in mass parts, comprise following component: Rhizoma Chuanxiong 12 ~ 14 parts, the Radix Angelicae Dahuricae 12 ~ 13 parts, Herba Asari 3 ~ 5 parts, Scorpio 6 ~ 7 parts, Scolopendra 6 ~ 7 parts, Radix Puerariae 15 ~ 17 parts and Radix Glycyrrhizae Preparata 6 ~ 7 parts.
A preparation method for treatment migraine remedy provided by the invention, comprises the steps:
(1) described Scolopendra, scorpion powder are broken into the ultramicro powder of particle diameter less than 10 μm;
(2) described Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari, Radix Puerariae and Radix Glycyrrhizae Preparata decoct with water 2 ~ 3 hours, filter, and collect filtrate and medicinal residues; Slag of getting it filled refilters after decocting with water 1 ~ 1.5 hour, the filtrate that the filtrate of collecting and first time collecting by filtration arrive is merged;
(3) ultramicro powder obtained in step (1) is added mix homogeneously in merging filtrate, obtain described medicine.
Preparation method preparation technology provided by the present invention is simple, and cost is low.Scolopendra, Scorpio are prepared into ultramicro powder and are used as medicine, and make the utilization rate of effective ingredient up to more than 90%.Remaining medicine decocts through 2 times, can the effective ingredient of each component of high efficiency extraction, promotes that each component plays significant synergistic function.
In order to improve the utilization rate of effective ingredient further, preferably, in described step (1), the particle diameter of ultramicro powder is less than 1 μm.
The consumption of water affects drug effect, in order to ensure fully to extract active component, and ensure that drug effect is optimum, preferably, in described step (2), the quality added water when first time decocts is 10 ~ 12 times of described Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari, Radix Puerariae and Radix Glycyrrhizae Preparata gross mass.
The preparation that a kind for the treatment of migraine remedy provided by the invention is prepared from.
Medicine provided by the invention can be prepared into pharmaceutical preparation, and the side effect of Chinese medicine preparation is little, rapid-action, evident in efficacy, patient can according to self need select dosage form, easy to use.
Preferably, the dosage form of described preparation comprises any one in tablet, granule, capsule, drop pill.
Preferably, pharmaceutically acceptable adjuvant is also comprised.
Preferably, described adjuvant comprises one or more in wetting agent, binding agent, filler, disintegrating agent, lubricant, coating material, excipient, antiseptic.
Compared with prior art, beneficial effect of the present invention is:
(1) one provided by the invention treats migrainous medicine, scientific formulation is exquisite, theoretical according to traditional Chinese medical science monarch, each component compatibility together, played significant collaborative reinforced effects, have the effect of significantly ease the pain attack times and pain degree, long-term utilization can be achieved good results to prevention of migraine, and side effect is little, patient's long-term taking can not cause discomfort.
(2) preparation method preparation technology provided by the present invention is simple, and cost is low.Scolopendra, Scorpio are prepared into ultramicro powder and are used as medicine, and make the utilization rate of effective ingredient up to more than 90%.Remaining medicine decocts through 2 times, can the effective ingredient of each component of high efficiency extraction, promotes that each component plays significant synergistic function.
(3) medicine provided by the invention can be prepared into preparation, and the side effect of preparation is little, rapid-action, evident in efficacy, patient can according to self need select dosage form, easy to use.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting the scope of the invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, be and can buy by commercially available the conventional products obtained.
Embodiment 1
Each amounts of components/the g of table 1 embodiment 1
Rhizoma Chuanxiong The Radix Angelicae Dahuricae Herba Asari Scorpio Scolopendra Radix Puerariae Radix Glycyrrhizae Preparata
8 8 1 3 3 10 2
Preparation method comprises the steps:
Accurately take above-mentioned medical material, Scolopendra, scorpion powder being broken into particle diameter is that the ultramicro powder of 1 μm is for subsequent use; Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari, Radix Puerariae and Radix Glycyrrhizae Preparata are decocted with water 2 hours, and amount of water is 10 times of above-mentioned five kinds of medical material gross masses, rear filtration, collects filtrate and medicinal residues; Slag of getting it filled decocts with water 1 hour again, filters, and the filtrate that the filtrate of collecting and first time collecting by filtration arrive is merged; The ultramicro powder of preparation is mixed homogeneously with merging filtrate, obtains medicine of the present invention.
Embodiment 2
Each amounts of components/the g of table 2 embodiment 2
Rhizoma Chuanxiong The Radix Angelicae Dahuricae Herba Asari Scorpio Scolopendra Radix Puerariae Radix Glycyrrhizae Preparata
10 15 3 4 4 12 5
Preparation method comprises the steps:
Accurately take above-mentioned medical material, Scolopendra, scorpion powder being broken into particle diameter is that the ultramicro powder of 2 μm is for subsequent use; Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari, Radix Puerariae and Radix Glycyrrhizae Preparata are decocted with water 3 hours, and amount of water is 10 times of above-mentioned five kinds of medical material gross masses, rear filtration, collects filtrate and medicinal residues; Slag of getting it filled decocts with water 1 hour again, filters, and the filtrate that the filtrate of collecting and first time collecting by filtration arrive is merged; The ultramicro powder of preparation is mixed homogeneously with merging filtrate, obtains medicine of the present invention.
Embodiment 3
Each amounts of components/the g of table 3 embodiment 3
Rhizoma Chuanxiong The Radix Angelicae Dahuricae Herba Asari Scorpio Scolopendra Radix Puerariae Radix Glycyrrhizae Preparata
12 12 3 6 6 15 6
Preparation method comprises the steps:
Accurately take above-mentioned medical material, Scolopendra, scorpion powder being broken into particle diameter is that the ultramicro powder of 2 μm is for subsequent use; Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari, Radix Puerariae and Radix Glycyrrhizae Preparata are decocted with water 3 hours, and amount of water is 10 times of above-mentioned five kinds of medical material gross masses, rear filtration, collects filtrate and medicinal residues; Slag of getting it filled decocts with water 1 hour again, filters, and the filtrate that the filtrate of collecting and first time collecting by filtration arrive is merged; The ultramicro powder of preparation is mixed homogeneously with merging filtrate, obtains medicine of the present invention.
Embodiment 4
Each amounts of components/the g of table 4 embodiment 4
Rhizoma Chuanxiong The Radix Angelicae Dahuricae Herba Asari Scorpio Scolopendra Radix Puerariae Radix Glycyrrhizae Preparata
14 13 6 7 7 17 7
Preparation method comprises the steps:
Accurately take above-mentioned medical material, Scolopendra, scorpion powder being broken into particle diameter is that the ultramicro powder of 2 μm is for subsequent use; Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari, Radix Puerariae and Radix Glycyrrhizae Preparata are decocted with water 3 hours, and amount of water is 10 times of above-mentioned five kinds of medical material gross masses, rear filtration, collects filtrate and medicinal residues; Slag of getting it filled decocts with water 1 hour again, filters, and the filtrate that the filtrate of collecting and first time collecting by filtration arrive is merged; The ultramicro powder of preparation is mixed homogeneously with merging filtrate, obtains medicine of the present invention.
Embodiment 5
Each amounts of components/the g of table 5 embodiment 5
Rhizoma Chuanxiong The Radix Angelicae Dahuricae Herba Asari Scorpio Scolopendra Radix Puerariae Radix Glycyrrhizae Preparata
15 14 6 8 4 18 8
Preparation method comprises the steps:
Accurately take above-mentioned medical material, Scolopendra, scorpion powder being broken into particle diameter is that the ultramicro powder of 1 μm is for subsequent use; Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari, Radix Puerariae and Radix Glycyrrhizae Preparata are decocted with water 3 hours, and amount of water is 12 times of above-mentioned five kinds of medical material gross masses, rear filtration, collects filtrate and medicinal residues; Slag of getting it filled decocts with water 1.5 hours again, filters, and the filtrate that the filtrate of collecting and first time collecting by filtration arrive is merged; The ultramicro powder of preparation is mixed homogeneously with merging filtrate, obtains medicine of the present invention.
Embodiment 6
Each amounts of components/the g of table 6 embodiment 6
Rhizoma Chuanxiong The Radix Angelicae Dahuricae Herba Asari Scorpio Scolopendra Radix Puerariae Radix Glycyrrhizae Preparata
16 15 6 10 10 20 10
Preparation method comprises the steps:
Accurately take above-mentioned medical material, Scolopendra, scorpion powder being broken into particle diameter is that the ultramicro powder of 1 μm is for subsequent use; Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari, Radix Puerariae and Radix Glycyrrhizae Preparata are decocted with water 3 hours, and amount of water is 12 times of above-mentioned five kinds of medical material gross masses, rear filtration, collects filtrate and medicinal residues; Slag of getting it filled decocts with water 1.5 hours again, filters, and the filtrate that the filtrate of collecting and first time collecting by filtration arrive is merged; The ultramicro powder of preparation is mixed homogeneously with merging filtrate, obtains medicine of the present invention.
Conventional filtered through gauze when filter method in the present invention can adopt field of Chinese medicines decocting herbs, coordinates twice decoction, can effective ingredient in high efficiency extraction medical material.Except filtered through gauze, other more efficient solid-liquid separating method also can be adopted, as filtration under diminished pressure, centrifugalize, membrance separation etc.Or when dose is larger, the active ingredient that may retain after twice decoction is more, can suitably increase decoction number of times.
Random selecting 350 patients, are divided into 7 groups.Experimental group 1-6 takes the medicine that embodiment of the present invention 1-6 provides, oral, takes three day, within early, middle and late one hour after meal, takes warm water and takes, each 8 grams.Matched group takes YANSUAN FUGUILIQIN JIAONANG according to explanation.Continuous treatment is after 1 month, and its Comparison of therapeutic is as shown in table 7.
Diagnostic criteria:
Cure: patient no longer occurs that cephalagra or occurrence number reduce more than 90%.
Take a turn for the better: occur that cephalagra number of times reduces more than 60%.
Invalid: migraine reduces number of times lower than 25%.
Table 7 medicine of the present invention and YANSUAN FUGUILIQIN JIAONANG Comparison of therapeutic result
Through above-mentioned clinical verification, the migrainous medicine for the treatment of provided by the present invention, has no side effect, and after patient's long-term taking, health there will not be malaise symptoms, and effective percentage is far away higher than YANSUAN FUGUILIQIN JIAONANG.
Typical clinical case is as follows:
Case one: man, 52 years old, patient's headache when examining, pain gesture was very acute, attacks punching and has a pain, pain as being stabbed, and connect and order tooth, accompany dizzy photophobia, gastral cavity uncomfortable in chest is swollen, nausea and vomiting, being irritable and getting angry easily, recurrent exerbation, spiritlessness and weakness, and dormancy of receiving is poor, and urine is adjusted, constipation with dry stool.Tongue is dim, white and thin fur, stringy and hesitant pulse.Be diagnosed as headache (obstruction of collaterals by blood stasis), rear oral medicine, takes three day, within one hour after meal, takes warm water and takes, each 8 grams, more than serveing on January, pain gesture is very acute, attacks punching and has a pain, pain as being stabbed, connect and order tooth, accompany dizzy photophobia, gastral cavity uncomfortable in chest is swollen, nausea and vomiting, being irritable and getting angry easily is comparatively front to take a turn for the better, then takes 1 month, and pain gesture is very acute, attack punching to have a pain, pain as being stabbed, connect and order tooth, accompany dizzy photophobia, gastral cavity uncomfortable in chest is swollen, nausea and vomiting, and being irritable and getting angry easily is clearly better.Stool is adjusted.
Case two: man, 65 years old, patient's headache when examining, pain gesture was very acute, pain as being stabbed, and connect and order tooth, accompany dizzy photophobia, gastral cavity uncomfortable in chest is swollen, nausea and vomiting, being irritable and getting angry easily, spiritlessness and weakness, and dormancy of receiving is poor, and urine is adjusted, constipation with dry stool.Tongue is dim, and tongue is white, hesitant pulse.Be diagnosed as headache (obstruction of collaterals by blood stasis), rear oral medicine, takes three day, within one hour after meal, takes warm water and takes, each 8 grams, more than serveing on January, pain gesture is very acute, pain as being stabbed, connect and order tooth, accompany dizzy photophobia, gastral cavity uncomfortable in chest is swollen, nausea and vomiting, being irritable and getting angry easily, the diseases such as spiritlessness and weakness are comparatively front to be taken a turn for the better, then it is very acute to take 1 month pain gesture, pain as being stabbed, connect and order tooth, accompany dizzy photophobia, gastral cavity uncomfortable in chest is swollen, nausea and vomiting, being irritable and getting angry easily, spiritlessness and weakness etc. are clearly better, and god is clear, and stool is adjusted.
Case three: female, 62 years old, when examining patient headache, pain gesture very acute, pain as being stabbed, attacks punching and has a pain, connect and order tooth, accompany dizzy photophobia, gastral cavity uncomfortable in chest is swollen, nausea and vomiting, receive dormancy can, two just adjust.Light red tongue is purple, and tongue is white, stringy and hesitant pulse.Be diagnosed as headache (obstruction of collaterals by blood stasis), rear oral medicine, takes three day, within one hour after meal, takes warm water and takes, each 8 grams, more than serveing on January, pain gesture is very acute, pain as being stabbed, attack punching to have a pain, connect and order tooth, accompany dizzy photophobia, gastral cavity uncomfortable in chest is swollen, nausea and vomiting is comparatively front to take a turn for the better, then takes 2 months, and pain gesture is very acute, pain as being stabbed, attacks punching and has a pain, and connects and order tooth, accompany dizzy photophobia, nausea and vomiting etc. are comparatively before clearly better, and receiving dormancy can.
Case four: man, 77 years old, when examining, patient had a headache unconsciousness, and pain as being stabbed, attacks punching and have a pain, vomiting sputum, susceptible to lose temper due to restlessness, receive sleep still can, urine is adjusted, large dry stool 1 row on the 4th.Tongue is dark violet, white and thin fur, stringy and hesitant pulse.Be diagnosed as headache (obstruction of collaterals by blood stasis), rear oral medicine, takes three day, within one hour after meal, takes warm water and takes, each 8 grams, more than serveing on January, headache unconsciousness, pain as being stabbed, attack punching to have a pain, vomiting sputum, susceptible to lose temper due to restlessness, dormancy difference of receiving is comparatively front to take a turn for the better, take 1 month again, headache unconsciousness, pain as being stabbed, attack punching to have a pain, gastral cavity abdomen feeling of fullness, vomiting sputum, susceptible to lose temper due to restlessness is clearly better, receive dormancy can, two just adjust.
Case five: man, 57 years old, patient's spiritlessness and weakness when examining, time sense headache unconsciousness, fixing do not move pain as being stabbed, attack punching and have a pain, vomiting tending to vomit, susceptible to lose temper due to restlessness, receive dormancy can, two just adjust.Tongue is dim, and tongue is white, and hesitant pulse is sliding.Be diagnosed as headache (obstruction of collaterals by blood stasis), rear oral medicine, takes three day, within one hour after meal, takes warm water and takes, each 8 grams, more than serveing on January, god is clear, time sense headache unconsciousness, fixing do not move pain as being stabbed, attack punching and have a pain, vomiting tending to vomit, susceptible to lose temper due to restlessness, dormancy difference of receiving is comparatively front to take a turn for the better, take January again, headache unconsciousness, fixes and does not move pain as being stabbed, attack punching to have a pain, vomiting tending to vomit, susceptible to lose temper due to restlessness is comparatively before clearly better.
Case six: man, 55 years old, patient's headache when examining, pain as being stabbed, sore spot was fixed, and attacks punching and has a pain, and connects and order tooth, accompanies dizzy photophobia, nausea and vomiting, being irritable and getting angry easily time bitterly very, and dormancy of receiving is poor, and two just adjust.Tongue is dim, and tongue is white, hesitant pulse.Once took flunarizine hydrochloride 10mg treatment every night, and had no improvement, be diagnosed as headache (obstruction of collaterals by blood stasis), rear oral medicine, day takes three times, within one hour after meal, takes warm water and takes, each 8 grams, more than serveing on January, pain as being stabbed, attacks punching and has a pain, and connects and order tooth, accompanies dizzy photophobia, nausea and vomiting, being irritable and getting angry easily, takes a turn for the better comparatively, then takes 1 month, pain as being stabbed, attacks punching and has a pain, and connects and order tooth, accompanies dizzy photophobia, nausea and vomiting, being irritable and getting angry easily etc. are comparatively before clearly better, and receiving dormancy can.
Case seven: female, 63 years old, when examining, patient had a headache unconsciousness, and pain gesture is very acute, pain as being stabbed, connected and order tooth, accompanied dizzy photophobia, vomiting sputum, being irritable and getting angry easily, recurrent exerbation, spiritlessness and weakness, receive sleep poor, urine tune, constipation with dry stool, 1 row on the 2nd.Tongue is dim, and tongue is white, stringy and hesitant pulse.Be diagnosed as headache (obstruction of collaterals by blood stasis), rear oral medicine, takes three day, within one hour after meal, takes warm water and takes, each 8 grams, more than serveing on January, headache unconsciousness, pain gesture is very acute, pain as being stabbed, connects and order tooth, accompany dizzy photophobia, vomiting sputum, being irritable and getting angry easily, recurrent exerbation, spiritlessness and weakness is comparatively front to take a turn for the better, then takes 1 month, headache unconsciousness, and pain gesture is very acute, pain as being stabbed, connects and order tooth, accompanies dizzy photophobia, vomiting sputum, being irritable and getting angry easily, the diseases such as recurrent exerbation are clearly better, and god is clear, and stool is adjusted.
Case eight: female, 48 years old, patient's spiritlessness and weakness when examining, headache unconsciousness, pain gesture very acute, pain as being stabbed, connect and order tooth, accompany dizzy photophobia, vomiting sputum, being irritable and getting angry easily, recurrent exerbation, receive can, sleeps poor, urine tune, constipation with dry stool, 1 row on the 3rd.Tongue is dim, and tongue is white, stringy and hesitant pulse.After taking hedex, have no improvement (specifically not quite clear), be diagnosed as headache (obstruction of collaterals by blood stasis), rear oral medicine, day takes three times, within one hour after meal, takes warm water and takes, each 8 grams, more than serveing on January, headache unconsciousness, pain gesture is very acute, pain as being stabbed, connects and order tooth, accompanies dizzy photophobia, gastral cavity abdomen feeling of fullness, vomiting sputum, being irritable and getting angry easily, recurrent exerbation is comparatively front to take a turn for the better, then takes unconsciousness of having a headache January, and pain gesture is very acute, pain as being stabbed, connects and order tooth, accompanies dizzy photophobia, vomiting sputum, being irritable and getting angry easily, recurrent exerbation etc. are clearly better, and god is clear, dormancy can, stool adjust.
Case nine: man, 68 years old, patient's severe headache when examining, attacked punching and has a pain, pain as being stabbed, and connect and order tooth, sore spot is fixed, and accompanies dizzy photophobia, nausea and vomiting, being irritable and getting angry easily, recurrent exerbation, and dormancy of receiving is poor, and two just adjust.Tongue is dim, and tongue is greasy in vain, and stringy and hesitant pulse is sliding.Be diagnosed as headache (obstruction of collaterals by blood stasis), rear oral medicine, takes three day, within one hour after meal, takes warm water and takes, each 8 grams, more than serveing on January, severe headache, attacks punching and has a pain, pain as being stabbed, connects and order tooth, accompany dizzy photophobia, nausea and vomiting, being irritable and getting angry easily, recurrent exerbation, dormancy of receiving is poor, takes a turn for the better, then take 1 month, severe headache comparatively, attack punching to have a pain, pain as being stabbed, connect and order tooth, accompany dizzy photophobia, nausea and vomiting, being irritable and getting angry easily, recurrent exerbation etc. are clearly better, and receiving dormancy can.
Case ten: man, 60 years old, patient's headache when examining, pain gesture is very acute, attacks punching and has a pain, pain as being stabbed, dizzy photophobia, time to feel gastral cavity uncomfortable in chest swollen, nausea and vomiting, being irritable and getting angry easily, recurrent exerbation, receive and sleep poor, two just adjust.Tongue is dim, white and thin fur, stringy and hesitant pulse.Be diagnosed as headache (obstruction of collaterals by blood stasis), rear oral medicine, takes three day, within one hour after meal, takes warm water and takes, each 8 grams, more than serveing on January, pain gesture is very acute, attacks punching and has a pain, pain as being stabbed, dizzy photophobia, gastral cavity uncomfortable in chest is swollen, nausea and vomiting, being irritable and getting angry easily, recurrent exerbation, dormancy difference of receiving is comparatively front to take a turn for the better, then takes 1 month, pain gesture is very acute, attacks punching and has a pain, pain as being stabbed, dizzy photophobia, gastral cavity uncomfortable in chest is swollen, nausea and vomiting, and the diseases such as being irritable and getting angry easily are clearly better, and receiving dormancy can.
Although illustrate and describe the present invention with specific embodiment, however it will be appreciated that can to make when not deviating from the spirit and scope of the present invention many other change and amendment.Therefore, this means to comprise all such changes and modifications belonged in the scope of the invention in the following claims.

Claims (10)

1. treat a migrainous medicine, it is characterized in that, in mass parts, comprise following component: Rhizoma Chuanxiong 8 ~ 16 parts, the Radix Angelicae Dahuricae 8 ~ 15 parts, Herba Asari 1 ~ 6 part, Scorpio 3 ~ 10 parts, Scolopendra 3 ~ 10 parts, Radix Puerariae 10 ~ 20 parts and Radix Glycyrrhizae Preparata 2 ~ 10 parts.
2. medicine according to claim 1, is characterized in that, in mass parts, comprises following component: Rhizoma Chuanxiong 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 14 parts, Herba Asari 3 ~ 6 parts, Scorpio 4 ~ 8 parts, Scolopendra 4 ~ 8 parts, Radix Puerariae 10 ~ 20 parts and Radix Glycyrrhizae Preparata 2 ~ 10 parts.
3. medicine according to claim 1, is characterized in that, in mass parts, comprises following component: Rhizoma Chuanxiong 12 ~ 14 parts, the Radix Angelicae Dahuricae 12 ~ 13 parts, Herba Asari 3 ~ 5 parts, Scorpio 6 ~ 7 parts, Scolopendra 6 ~ 7 parts, Radix Puerariae 15 ~ 17 parts and Radix Glycyrrhizae Preparata 6 ~ 7 parts.
4. a preparation method for medicine described in any one of claims 1 to 3, is characterized in that, comprise the steps:
(1) described Scolopendra, scorpion powder are broken into the ultramicro powder of particle diameter less than 10 μm;
(2) described Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari, Radix Puerariae and Radix Glycyrrhizae Preparata decoct with water 2 ~ 3 hours, filter, and collect filtrate and medicinal residues; Slag of getting it filled refilters after decocting with water 1 ~ 1.5 hour, the filtrate that the filtrate of collecting and first time collecting by filtration arrive is merged;
(3) ultramicro powder obtained in step (1) is added mix homogeneously in merging filtrate, obtain described medicine.
5. preparation method according to claim 4, is characterized in that, in described step (1), the particle diameter of ultramicro powder is less than 1 μm.
6. preparation method according to claim 4, is characterized in that, in described step (2), the quality added water when first time decocts is 10 ~ 12 times of described Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari, Radix Puerariae and Radix Glycyrrhizae Preparata gross mass.
7. the preparation that described in an any one of claims 1 to 3, medicine is prepared from.
8. preparation according to claim 7, is characterized in that, the dosage form of described preparation be selected from tablet, granule, capsule, drop pill any one.
9. preparation according to claim 7, is characterized in that, also comprises pharmaceutically acceptable adjuvant.
10. preparation according to claim 9, is characterized in that, described pharmaceutically acceptable adjuvant comprise in wetting agent, binding agent, filler, disintegrating agent, lubricant, coating material, excipient, antiseptic one or more.
CN201510197036.8A 2015-04-23 2015-04-23 Medicine for treating migraine, as well as preparation method and preparation of medicine Pending CN104758346A (en)

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CN105326918A (en) * 2015-11-25 2016-02-17 禤燕华 Traditional Chinese medicine composition for treating migraine and preparation method thereof

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