CN107753921B

CN107753921B - Traditional Chinese medicine navel plaster for treating hyperemesis gravidarum

Info

Publication number: CN107753921B
Application number: CN201711348437.4A
Authority: CN
Inventors: 王瑞杰; 余金钟
Original assignee: Henan University of Traditional Chinese Medicine HUTCM
Current assignee: Henan University of Traditional Chinese Medicine HUTCM
Priority date: 2017-12-15
Filing date: 2017-12-15
Publication date: 2021-05-25
Anticipated expiration: 2037-12-15
Also published as: CN107753921A

Abstract

The invention relates to a traditional Chinese medicine navel-applied agent for treating hyperemesis gravidarum, which can effectively solve the problem of medication of hyperemesis gravidarum and adopts the technical scheme that the traditional Chinese medicine is prepared from the following components in parts by weight: 10-30g of clove, 15-30g of ginger processed pinellia tuber, 25-50g of ginger, 10-30g of ginger bamboo shavings, 10-30g of perilla leaf, 10-30g of dogwood, 10-30g of chicken's gizzard-membrane and 10-30g of scorched medicated leaven.

Description

Traditional Chinese medicine navel plaster for treating hyperemesis gravidarum

Technical Field

The invention relates to the field of medicines, in particular to a traditional Chinese medicine navel patch for treating hyperemesis gravidarum.

Background

Hyperemesis gravidarum is a group of symptoms which mostly occur between 4 and 16 weeks of gestation and take severe nausea and vomiting as important symptoms, and the incidence rate is about 0.3 to 1 percent. The pregnant women suffer from water electrolyte disorder and fat metabolism disorder due to severe vomiting and long-term incapability of eating, and then metabolic acidosis occurs. If the treatment is not timely or improper, nervous system symptoms can appear, and even serious consequences such as liver and kidney failure and death can occur.

The traditional Chinese medicine calls hyperemesis gravidarum as hyperemesis gravidarum, which is one of the common diseases in the early stage of pregnancy, and the book Guangjiang Ji (the book Guangxi Zong Ji) states that a pernicious person means nausea and diet resistance caused by pregnancy. This syndrome is caused by the adverse ascending of qi which invades the stomach and the stomach is depressed. For the syndrome of different syndromes of spleen deficiency, stomach heat and phlegm-dampness, the treatment is mainly to strengthen spleen and stomach, clear stomach and resolve phlegm, check adverse rise of qi and arrest vomiting.

The navel application therapy is a method of treating diseases by applying the prepared medicine on the navel of a patient, covering a plastic film and gauze, and then fixing with an adhesive tape (ancient method is to cover leaves or vegetable leaves and then bundle with a cloth). The history of traditional Chinese medicine navel therapy for treating diseases has been over 2000 years, and the part of the navel is very important and is called Shenque. Explanation of "the dog-house" is: the spirit is the most varied, so named as 'spirit'; the 'threshold' is a median gate to show the expense. The traditional Chinese medicine considers that the navel is a door of heart and kidney traffic, namely a place where spirit goes up and down, goes out, changes and disappears, belongs to an important acupoint of the conception vessel, can reach five zang organs and six fu organs, and regulates physiological activities of various viscera. Just as the famous medical Wu Shi machine of Qing Dynasty, "Shenque administration can dredge the channels and collaterals, open orifices and penetrate bones. The drug is administrated from the umbilical region, which is beneficial to the meridian tropism of the drug, leads the drug effect to directly reach the disease site along the meridian, regulates qi and blood yin and yang, expels pathogenic factors and helps vital qi, and has very important effect on preventing and treating diseases. From modern medical theory, the navel skin is thinnest and is easier to penetrate people than other transdermal administration sites. Meanwhile, no fat tissue is under the navel, the peritoneum under the navel has rich blood vessels, the external medicament is easy to absorb and can quickly enter blood circulation, the bioavailability is high, and the efficacy of the medicament can directly reach the focus, thereby achieving the purpose of treatment. In addition, peripheral nerves of the umbilical region are rich and sensitive, the nerve endocrine system can be adjusted and the functions of all organs can be improved through hot medicated application stimulation, the pregnant women are not suitable to take medicines, and no effective external medicine for hyperemesis gravidarum exists at present, so that the invention provides the traditional Chinese medicine navel-applied agent for treating hyperemesis gravidarum.

Disclosure of Invention

In view of the above situation, the present invention aims to provide a Chinese medicine navel patch for treating hyperemesis gravidarum, which can effectively solve the medication problem of hyperemesis gravidarum.

The technical scheme of the invention is that the traditional Chinese medicine is prepared from the following components in parts by weight: 10-30g of clove, 15-30g of ginger processed pinellia tuber, 25-50g of ginger, 10-30g of ginger bamboo shavings, 10-30g of perilla leaf, 10-30g of dogwood, 10-30g of chicken's gizzard-membrane and 10-30g of scorched medicated leaven, and the medicine is prepared by grinding the medicines into powder and blending ginger juice into paste.

The Chinese medicinal navel paste is prepared from pure Chinese medicaments, can relieve the toxic and side effects of the medicaments on liver and kidney, can avoid the stimulation of orally taken medicaments on gastrointestinal tracts, is easy to accept by patients, can effectively relieve hyperemesis gravidarum, and is an innovation of the Chinese medicinal navel paste for treating hyperemesis gravidarum.

Detailed Description

The following examples further illustrate the embodiments of the present invention in detail.

Example 1

The invention, when embodied, may be made from the following by weight: 11g of clove, 29g of ginger processed pinellia tuber, 26g of ginger, 11g of ginger bamboo shavings, 29g of perilla leaf, 11g of dogwood, 29g of chicken's gizzard-membrane and 11g of scorched medicated leaven.

Example 2

When the invention is implemented, the invention can also be prepared by the following weight portions: 20g of clove, 22g of ginger processed pinellia tuber, 37g of ginger, 20g of ginger bamboo shavings, 20g of perilla leaf, 20g of dogwood, 20g of chicken's gizzard-membrane and 20g of scorched medicated leaven.

Example 3

When the invention is implemented, the invention can also be prepared by the following weight portions: 29g of clove, 16g of ginger processed pinellia tuber, 49g of ginger, 11g of ginger bamboo shavings, 29g of perilla leaf, 11g of dogwood, 29g of chicken's gizzard-membrane and 11g of scorched medicated leaven.

Clove: it can be used for treating stomach cold, pain and distention, singultus, vomiting and diarrhea, arthralgia, hernia pain, halitosis, and toothache.

Ginger processed pinellia: has effects of dispelling pungent, warming, dredging, eliminating phlegm, and eliminating dampness, and can be used for treating phlegm obstruction, chest and gastric cavity stuffiness and oppression; it is important to check adverse rise of qi and arrest vomiting, so it is indicated for vomiting and regurgitation, stuffiness and oppression in chest and epigastrium and globus hystericus.

Ginger: pungent and slightly warm, entering lung, spleen and stomach meridians, with the following effects: induce sweating to relieve exterior syndrome, warm middle energizer to arrest vomiting, warm lung to relieve cough, relieve toxicity of fish and crab, and relieve toxicity of herbs. Is suitable for treating wind-cold, headache, phlegm and fluid retention, cough, stomach cold and emesis; when the patient suffers from ice, snow, water dampness and cold, the decoction of ginger is taken quickly to promote blood circulation and dispel cold evil.

Ginger bamboo shavings: has effects of clearing heat, eliminating phlegm, relieving restlessness, and relieving vomit. Can be used for treating phlegm-heat cough, gallbladder fire with phlegm, palpitation, vexation, insomnia, apoplexy, phlegm stagnation, stiff tongue, stomach heat emesis, vomiting, pregnancy obstruction, and threatened abortion. The caulis Bambusae in Taenia is prepared by mixing caulis Bambusae in Taenia with succus Zingiberis recens, and parching to yellow. It is good at resolving phlegm and stopping vomiting.

Perilla leaf: nature and taste: pungent, mild, non-toxic, meridian tropism: the spleen meridian and the lung meridian. The functional indications are as follows: relieving exterior syndrome, dispelling cold, regulating qi-flowing, harmonizing ying. It can be used for treating common cold, wind-cold, aversion to cold, fever, cough, headache, no sweat, asthma, fullness and distention in chest and abdomen, nausea and diarrhea, obstruction in pharynx, pernicious vomiting, threatened abortion, fish and crab toxin, carbuncle, sore, and snake poison and hot.

Dogwood fruit: tonifying liver and kidney, astringing, arresting discharge, arresting seminal emission, arresting polyuria, stopping metrorrhagia, stopping sweating, promoting the production of body fluid, quenching thirst, and can be used for treating soreness and pain of waist and knees, dizziness and tinnitus, amnesia, spermatorrhea, enuresis, frequent micturition, metrorrhagia, leukorrhagia, menoxenia, profuse sweat, exhaustion, internal heat, and diabetes.

Endothelium corneum gigeriae galli: sweet and cold in nature. It enters spleen, stomach, small intestine and bladder meridians. The efficacy is as follows: promote digestion, invigorate stomach, help digestion, astringe essence and stop enuresis. Can promote gastric secretion, improve gastric acidity and digestion, enhance gastric motility, and accelerate gastric emptying.

Charred medicated leaven: medicated leaven contains yeast, amylase, ergosterol, volatile oil, fat, protein, vitamin B, etc. Therefore, the food has the excellent effects of promoting digestion, removing food stagnation, harmonizing stomach, stopping vomiting, relieving distension, treating dysentery, increasing appetite, promoting metabolism and the like. Can be clinically used for treating various diseases such as chronic gastritis, atrophic gastritis, acute gastroenteritis, amebic dysentery, abdominal distension, abdominal pain, diarrhea, infantile simple dyspepsia, anorexia, dyspepsia and the like. People feel old soil on the surface of the building in weekdays, and the building is low in price and cannot be looked after. In fact, the medicated leaven can show the spirit only by applying the method, has remarkable efficacy, low price and high effect.

The components are scientific and reasonable in compatibility and mutually supported, have the effects of strengthening spleen and stomach, clearing stomach and reducing phlegm, and calming adverse-rising energy and preventing vomiting, are effectively used for treating hyperemesis gravidarum, have obvious curative effects, and are fully proved by clinical data, and the relevant clinical data are as follows:

1 object

1.1 selection of subjects (1) inclusion criteria: refer to the diagnosis standard of hyperemesis gravidarum in gynaecology and obstetrics science; the patients can normally think and can cooperate with the treatment; (2) exclusion criteria: emesis symptoms caused by gastroenteritis, biliary tract diseases, intracranial hypertension, meningitis, and brain tumor. (3) Rejection and shedding standard: other antiemetic drugs and/or therapies were not used as required during the study; inability or reluctance to continue to participate in the study due to other adverse events or causes such as skin irritation, increased vomiting, etc.; the treatment course is not completed according to the regulations for various reasons. Patients who are not treated with the treatment course and require to stop treatment are not regarded as the exfoliative case.

1.2 general data selection 2015 6 months-2017 12 months in gynecologic hospitalization of pregnancy vomit 90 cases of patients in gynecologic department of traditional Chinese medicine, a single-blind random control design is adopted, and after evaluation, according to the admission sequence of patients, single-size classification is carried out to obtain a control group, double-size classification is carried out to obtain an observation group, and 45 cases are respectively carried out. The age of the control group is 23-37 (26.6 +/-1.7) years; 7-16 (12.0 +/-1.7) weeks after pregnancy; 33 cases of primiparity and 12 cases of menstruation and lying-in women; the observation group ages 21-39 (27.5 +/-2.6); 6-17 (12.1 +/-1.8) weeks of gestation; 30 cases of primiparity and 15 cases of menstruation and lying-in women; the age, culture degree, gestational period, gestational parity and disease condition of the 2 patients have no significant difference and are comparable.

2 control group

2.1 conventional fetus protection treatment, according to blood biochemistry, urine ketone body and other detection indexes, the water loss and electrolyte condition are determined, the total amount of supplemented liquid per day is 2000 mL, including 500 mL of 10% glucose injection, 1000mL of 5% glucose saline and 500 mL of ringer's solution (2 g of vitamin C injection and 200mg of vitamin B6 injection are added); 2g of potassium is supplemented every day. 5d is 1 course of treatment.

2.2 Observation group on the basis of control group, the medicine patch of the invention is applied to navel (Shenque acupoint) with gauze, once a day, for 5 days as a treatment course.

2.3 the therapeutic effect judgment standard carries out comprehensive evaluation on the total effective rate, the main symptoms, the disappearance of physical signs and the satisfaction degree of patients at the end of 1 treatment course. The efficacy evaluation therapeutic effect standard is formulated according to the traditional Chinese medicine disease diagnosis therapeutic effect standard. And (3) healing: vomiting stopped, clinical symptoms disappeared, diet was normal, no recurrence after drug withdrawal, and uretone body was negative. The effect is shown: vomiting is obviously relieved or disappeared, relapse occurs after the medicine is stopped, and the body of the ketonuria is improved. Effective, the vomit symptom is reduced, the urine ketone body is positive. The symptoms of vomiting are not improved or aggravated, the urine ketone body is positive, or the pregnancy is terminated by operation.

2.4 statistical methods statistical analyses were performed using SPSS 16.0, the metrology data were expressed in X + -S, two independent sample t tests were used, the count data were tested in X2 and in rank sum, P <0.05 indicating that the differences were statistically significant.

3 statistical treatment

TABLE 1 comparison of the therapeutic effects of the clinical symptoms of two groups of hyperemesis gravidarum patients

Group of	N	Recovery method	Show effect	Is effective	Invalidation	Total effective rate
							Control group	45	10	9	6	20	55.55%
Observation group	45	18	12	12	3	93.33%
							Z				2.006
P				＜0.05

From the above, it is clear that the curative effect of the clinical symptoms of two groups of hyperemesis gravidarum patients is compared, the curative effect of the observed group is obviously superior to that of the control group, and the difference has statistical significance (P < 0.05), as shown in Table 1.

4 conclusion

The navel sticking agent is simple and easy to implement, can reduce the toxic and side effects of the medicine on liver and kidney, can avoid the stimulation of the oral medicine on gastrointestinal tract, is easy to accept by patients, can effectively relieve hyperemesis gravidarum, is also suitable for old and young patients with vomiting symptoms and difficult medicine taking, has obvious curative effect through clinical application, and has practical clinical significance and good popularization and application values.

Claims

1. A traditional Chinese medicine navel-applied agent for treating hyperemesis gravidarum is characterized in that the traditional Chinese medicine is prepared from the following components in parts by weight: 10-30g of clove, 15-30g of ginger processed pinellia tuber, 25-50g of ginger, 10-30g of ginger bamboo shavings, 10-30g of perilla leaf, 10-30g of dogwood, 10-30g of chicken's gizzard-membrane and 10-30g of scorched medicated leaven, and the medicine is prepared by grinding the medicines into powder and blending ginger juice into paste.

2. The traditional Chinese medicine navel patch for treating hyperemesis gravidarum according to claim 1, which is prepared from the following raw materials in parts by weight: 11g of clove, 29g of ginger processed pinellia tuber, 26g of ginger, 11g of ginger bamboo shavings, 29g of perilla leaf, 11g of dogwood, 29g of chicken's gizzard-membrane and 11g of scorched medicated leaven.

3. The traditional Chinese medicine navel patch for treating hyperemesis gravidarum according to claim 1, which is prepared from the following raw materials in parts by weight: 20g of clove, 22g of ginger processed pinellia tuber, 37g of ginger, 20g of ginger bamboo shavings, 20g of perilla leaf, 20g of dogwood, 20g of chicken's gizzard-membrane and 20g of scorched medicated leaven.

4. The traditional Chinese medicine navel patch for treating hyperemesis gravidarum according to claim 1, which is prepared from the following raw materials in parts by weight: 29g of clove, 16g of ginger processed pinellia tuber, 49g of ginger, 11g of ginger bamboo shavings, 29g of perilla leaf, 11g of dogwood, 29g of chicken's gizzard-membrane and 11g of scorched medicated leaven.