CN116850258A - Chinese medicinal composition with antiemetic effect and preparation method thereof - Google Patents
Chinese medicinal composition with antiemetic effect and preparation method thereof Download PDFInfo
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- CN116850258A CN116850258A CN202310720134.XA CN202310720134A CN116850258A CN 116850258 A CN116850258 A CN 116850258A CN 202310720134 A CN202310720134 A CN 202310720134A CN 116850258 A CN116850258 A CN 116850258A
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Insects & Arthropods (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Animal Husbandry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Otolaryngology (AREA)
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- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The application belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition with an anti-emetic effect and a preparation method thereof. The Chinese medicinal composition comprises folium Perillae, coptidis rhizoma, fructus Amomi, radix aucklandiae, rhizoma Pinelliae, rhizoma Zingiberis recens, rhizoma Dioscoreae, and Mel. Pharmacological experiments and clinical use experience prove that the traditional Chinese medicine composition disclosed by the application has better effects of relieving and treating vomiting of pregnancy, has an effective rate of 92.86% in clinical treatment of vomiting of pregnancy, can effectively relieve clinical symptoms such as nausea and vomiting, dizziness and anorexia of patients, and can be eaten instantly, and the like, and the ointment prepared from the traditional Chinese medicine composition is simple in process and can be further produced in a large scale.
Description
Technical Field
The application relates to a traditional Chinese medicine composition and medical application thereof, in particular to a traditional Chinese medicine composition and application thereof in preparing a medicine for preventing or treating vomiting, and belongs to the technical field of traditional Chinese medicines.
Background
Vomiting is a protective mechanism of the human body that can expel harmful substances ingested into the stomach outside the body, but frequent and severe vomiting can cause various harmful consequences: malnutrition, loss of water, electrolyte disorders, acid-base imbalance, and even esophageal and gastric lesions.
Vomiting is very common in clinic, and can be caused by functional disorders or organic diseases, and can also be caused by lesions of the digestive system itself, or by disorders outside the digestive system or systemic diseases. Repeated severe vomiting can occur in gastroesophageal cardiac tear syndrome, hematemesis of varying degrees, and serious cases can even cause esophageal rupture, which is a surgical emergency. Frequent and persistent vomiting often results in metabolic disorders such as dehydration, alkalosis, hypokalemia, and the like. The unconscious person may cause pneumonia, even choking death, due to vomit inhalation.
Pregnancy vomiting (vomit ing of pregnancy), also called vomiting of pregnancy, is an early pregnancy reaction that occurs during pregnancy. This occurs for unknown reasons and may be related to various factors. The main clinical manifestations are nausea and vomiting, inappetence, poor spirit, and serious cases can cause dehydration or acidosis. The patient with lighter vomiting of pregnancy generally needs no treatment and can be relieved by oneself; serious patients need to be treated actively to improve the symptoms of vomiting. 80% -90% of women show pregnancy vomiting in early pregnancy, and 10% -20% of pregnant women can continuously give birth to nausea and vomiting symptoms.
Disclosure of Invention
The application aims at providing a traditional Chinese medicine composition, which contains perilla leaves, coptis chinensis, fructus amomi, elecampane, pinellia ternate, ginger, chinese yam and honey.
Specifically, the traditional Chinese medicine composition comprises the following components:
40-100 parts of perilla leaf, 10-40 parts of coptis chinensis, 30-70 parts of fructus amomi,
20-50 parts of costustoot, 30-60 parts of pinellia ternate, 20-50 parts of ginger,
50-100 parts of yam and 50-150 parts of honey.
Preferably, the traditional Chinese medicine composition comprises the following components:
50-80 parts of perilla leaf, 20-35 parts of coptis root, 40-65 parts of fructus amomi,
30-40 parts of costustoot, 30-40 parts of pinellia ternate, 30-40 parts of ginger, and,
80-100 parts of yam and 80-120 parts of honey.
Further preferably, the traditional Chinese medicine composition contains the following components:
60 parts of perilla leaf, 25 parts of coptis chinensis, 45 parts of fructus amomi,
33 parts of costustoot, 33 parts of pinellia ternate, 33 parts of ginger, and,
80 parts of Chinese yam and 100 parts of honey.
The rhizoma Pinelliae in the above Chinese medicinal composition is rhizoma Pinelliae processed with ginger.
The second object of the present application is to provide a method for preparing the Chinese medicinal composition, which comprises the following steps:
1) Sieving Coptidis rhizoma powder with 20 mesh sieve, dissolving in 40-45deg.C hot water, maintaining temperature, and filtering with 80 mesh sieve.
2) Decocting the materials except Mel in 6-12 times of water for 50-80 min, filtering, adding 4-8 times of water into the residue, decocting for 40-60 min, filtering, mixing filtrates, concentrating at 70-80deg.C to relative density of 1.03-1.07, standing, collecting supernatant, adding Coptidis rhizoma powder fluid extract, concentrating at 70-80deg.C to relative density of 1.17-1.22, cooling, and standing to obtain paste;
3) Dissolving gelatin in water, mixing CMC-Na, PVP and sorbitol, adding into gelatin solution, adding
And 5% ethanol solution is fully expanded, then the paste and the honey in the step 2) are added, stirred and fully crosslinked and coated on non-woven fabrics, the non-stick film is covered, and the plaster is obtained after drying.
The second purpose of the application is to provide the medical application of the traditional Chinese medicine composition, namely the application of the traditional Chinese medicine composition in preparing medicines for preventing, relieving and/or treating vomiting.
Further, the vomiting refers to vomiting caused by diseases and/or medicines, and can also be vomiting of pregnancy.
The application further aims at providing a traditional Chinese medicine preparation, which is prepared from the traditional Chinese medicine composition.
Furthermore, the traditional Chinese medicine preparation is an oral preparation and/or an external preparation; preferably, the traditional Chinese medicine preparation is an external preparation; further preferably, the Chinese medicinal preparation is an external ointment.
Compared with the prior art, the application has the remarkable technical effects that:
clinical experience proves that the traditional Chinese medicine composition has obvious antiemetic effect, especially for vomiting of pregnancy, the effective rate of clinical treatment of the traditional Chinese medicine composition is up to 92.86%, and the traditional Chinese medicine composition can effectively relieve and treat vomiting of pregnancy and improve clinical symptoms of nausea, vomiting, dizziness, anorexia, instant vomiting and the like of patients.
Drawings
FIG. 1. Statistics of kaolin ingestion by rats of each example group;
FIG. 2. Statistics of feeding conditions of rats in each example group;
FIG. 3 is a graph showing the water intake statistics of rats in each example group;
figure 4 statistics of weight change in rats of each example group.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The present application is further illustrated below with reference to specific examples, which are to be construed as merely illustrative of the application and not limiting of its scope, as various equivalent modifications to the application will fall within the scope of the application as defined in the appended claims after reading the application.
Example 1: a patch containing Chinese medicinal composition is prepared from the following components:
40 g of perilla leaf, 10 g of coptis root, 30 g of fructus amomi,
20g of costustoot, 30 g of pinellia tuber, 20g of ginger,
50 g of yam and 50 g of honey.
The preparation process comprises the following steps:
the processing method of all the traditional Chinese medicinal materials is as follows:
1) Sieving Coptidis rhizoma powder with 20 mesh sieve, dissolving in 40-45deg.C hot water, maintaining temperature, and filtering with 80 mesh sieve.
2) Decocting the materials except Mel in 6-12 times of water for 50-80 min, filtering, adding 4-8 times of water into the residue, decocting for 40-60 min, filtering, mixing filtrates, concentrating at 70-80deg.C to relative density of 1.03-1.07, standing, collecting supernatant, adding Coptidis rhizoma powder fluid extract, concentrating at 70-80deg.C to relative density of 1.17-1.22, cooling, and standing to obtain paste;
3) Dissolving gelatin in water, uniformly mixing CMC-Na, PVP and sorbitol, adding into gelatin solution, adding 5% ethanol solution for full expansion, adding the paste and honey in the step 2), stirring, fully crosslinking, coating on non-woven fabrics, covering anti-sticking film, and drying to obtain the plaster.
Example 2: a patch containing Chinese medicinal composition is prepared from the following components:
100g of perilla leaf, 40 g of coptis chinensis, 70 g of fructus amomi,
50 g of costustoot, 60 g of pinellia tuber, 50 g of ginger, and,
100g of Chinese yam and 150 g of honey.
The preparation process is the same as in example 1.
Example 3: a Chinese medicinal composition in the form of patch comprises the following components
50 g of perilla leaf, 20g of coptis root, 40 g of fructus amomi,
30 g of costustoot, 30 g of pinellia tuber, 30 g of ginger, 30 g of,
80 g of yam and 80 g of honey.
The preparation process is the same as in example 1.
Example 4: a Chinese medicinal composition in the form of patch comprises the following components
80 g of perilla leaf, 35 g of coptis chinensis, 65 g of fructus amomi,
40 g of costustoot, 40 g of pinellia tuber, 40 g of ginger, 40 g of common ginger,
100g of Chinese yam and 120 g of honey.
The preparation process is the same as in example 1.
Example 5: a Chinese medicinal composition in the form of patch comprises the following components
60 g of perilla leaf, 25 g of coptis chinensis, 45 g of fructus amomi,
33 g of costustoot, 33 g of pinellia tuber, 33 g of ginger, 33 g of Chinese ginger,
80 g of Chinese yam and 100g of honey.
The preparation process is the same as in example 1.
Comparative example 1: a Chinese medicinal composition in the form of patch comprises the following components
60 g of perilla leaf, 25 g of coptis chinensis, 45 g of fructus amomi,
Agastache rugosus 33 g pinellia tuber 33 g ginger 33 g,
80 g of Chinese yam and 100g of honey.
The preparation process is the same as in example 1.
Comparative example 2: a patch containing Chinese medicinal composition is prepared from the following components:
perilla leaf 15 g coptis root 25 g amomum fruit 25 g,
55 g of costustoot, 23 g of pinellia tuber, 55 g of ginger,
100g of Chinese yam and 120 g of honey.
The preparation process is the same as in example 1.
Comparative example 3: a patch containing Chinese medicinal composition is prepared from the following components:
60 g of perilla leaf, 25 g of phellodendron bark, 45 g of amomum fruit,
33 g of costustoot, 33 g of pinellia tuber, 33 g of ginger, 33 g of Chinese ginger,
80 g of Chinese yam and 100g of honey.
The preparation process is the same as in example 1.
Comparative example 4: a patch containing Chinese medicinal composition is prepared from the following components:
33 g of pinellia tuber, 33 g of perilla stem, 60 g of dried ginger and 33 g of
Cinnamon 15 g clove 15 g licorice 10 g
The preparation process comprises the following steps: decocting in water for 2 times each for 1.5 hr, mixing decoctions, concentrating to soft extract, adding above Mel, and mixing. The composition can be applied.
Comparative example 5: a patch containing Chinese medicinal composition is prepared from the following components:
93 g of perilla leaf, 25 g of coptis root, 45 g of fructus amomi,
33 g of costustoot, 33 g of ginger and 80 g of yam
100g of honey.
The preparation process is the same as in example 1.
Comparative example 6: a patch containing Chinese medicinal composition is prepared from the following components:
60 g of perilla leaf, 25 g of coptis chinensis, 45 g of fructus amomi,
33 g of costustoot, 33 g of pinellia tuber, 33 g of ginger, 33 g of Chinese ginger,
80 g of Chinese yam and 100g of honey.
The processing method of all the traditional Chinese medicinal materials is as follows:
1) Decocting the materials except Mel in 6-12 times of water for 50-80 min, filtering, adding 4-8 times of water into the residue, decocting for 40-60 min, filtering, mixing filtrates, concentrating at 70-80deg.C to relative density of 1.03-1.07, standing, collecting supernatant, adding Coptidis rhizoma powder fluid extract, concentrating at 70-80deg.C to relative density of 1.17-1.22, cooling, and standing to obtain paste;
2) Dissolving gelatin in water, uniformly mixing CMC-Na, PVP and sorbitol, adding into gelatin solution, adding water for full expansion, adding the paste and honey in the step 2), stirring, fully crosslinking, coating on non-woven fabrics, covering an anti-sticking film, and drying to obtain the plaster.
In the preparation method of comparative example 6, the content of berberine is significantly lower than that of other examples, and the effect of preventing and treating emesis is found to be poor in pharmacological experiments.
The application focuses on the theory of traditional Chinese medicine and the mechanism of middle energizer, monarch, minister, assistant and guide, in the formula, pinellia tuber and perilla leaf with pungent and warm are taken as monarch, pinellia tuber is good for lowering adverse qi and preventing vomiting, perilla She Shan moves qi and harmonizes stomach, and the two are taken as monarch to play a main role. The ministerial drugs are coptis chinensis with bitter and cold property for purging liver heat, and the banksia rose and the fructus amomi are used for opening spleen and harmonizing stomach, so that the holy medicine ginger for vomit can be used for stopping vomit. The monarch, minister, assistant and minister drugs are used for regulating the level of cold and heat, and harmonizing liver and stomach. Mountain herb is an adjuvant drug with the actions of tonifying spleen and nourishing stomach. Honey is used as adjuvant drug to tonify middle energizer and regulate various drugs. The combination of the medicines obviously improves the vomiting phenomenon and obviously reduces the food intake in pharmacological experiments.
The traditional Chinese medicine composition has obvious antiemetic effect, especially for vomiting of pregnancy, has the effective rate of up to 92.86% in clinical treatment, can effectively relieve and treat vomiting of pregnancy, and improves clinical symptoms of nausea, vomiting, dizziness, anorexia, vomiting after eating and the like of patients.
1. The emplastrum of the application has therapeutic effect on the rat pica model
Currently, the rat pica model is the internationally preferred model of emesis. The degree of nausea and vomiting was indirectly observed by observing how much kaolin was dosed. In the experiment, the prevention and treatment effect of the embodiment group of the application on the pica of rats is observed by using a model of pica of rats caused by cisplatin, and the effect of the embodiment formula of the application on preventing and treating vomiting is discussed initially, so that a basis is provided for clinical medication.
1.1 Experimental materials
SD rats, 220 g.+ -.20 g, were acclimatized for one week prior to the experiment, and were given a certificate number SYXK 2018 0008.
1.2 pharmaceutical products and reagents
Cisplatin for injection, national medicine standard H20023461, qilu pharmaceutical Co., ltd, is diluted to 0.4mg/m1 by sterile physiological saline during experiments; physiological saline; the ointment prepared by the application.
The embodiment of the application comprises the following steps: examples 1, 2, 5 and comparative examples 1-5 were applied to the Shenque acupoint of rats. .
Positive control group: the compound scopolamine hydrobromide emplastrum, nantong Baiyi pharmaceutical Co., ltd, chinese medicine standard H32025500, is applied to the Shenque acupoint of rats.
1.3 modeling and packet administration
Administration: model, blank, positive control, examples 1, 2, 5 and comparative examples 1-5. 10 rats in each group were fed in a single cage, ginger summer paste was applied to the positive control group, examples 1, 2, 5 and comparative examples 1-5, and applied to the shenque acupoint of the rats, after 2 days of adaptation, the rats were observed to have no abnormalities, and kaolin particles were started to be fed and separated from the feed so as to become familiar with the presence of kaolin.
After 3 days of kaolin dosing, most rats had no longer ingested kaolin. Rats started to be dosed 1 hour after the stomach began to model. Each group was subjected to intraperitoneal injection of cisplatin at 1.5ml/100 g. Wherein, the blank group is administrated with physiological saline for intraperitoneal injection, and other groups are all administrated with cisplatin liquid medicine with concentration of 0.4 mg/ml. Cisplatin dose is 6mg/kg, and after 72 hours of molding, cervical vertebrae were removed and sacrificed.
1.4 project index detection and results
Each group was subjected to daily 8:30 recording of the index, including changes in the amount of kaolin ingested, feed ingested, water intake, weight, and the like, in rats until 72 hours after molding.
1.5 data analysis
Statistics of the data were performed using GrapPad prsim 6.0.
1.6 results and analysis
1.6.1 statistics of the feeding Kaolin in rats
On day 1 of kaolin administration, all groups of rats almost had the phenomenon of feeding kaolin, and on days 2 and 3 of kaolin administration, rats fed kaolin gradually decreased in amount, and on day 3 almost had no feeding. After molding, the amount of kaolin ingested by each group of rats injected with cisplatin was increased to varying degrees. The kaolin intake of rats in the model group was significantly higher than that of the blank group (P < 0.01) 24 hours after molding, and the difference was significant, indicating that the cisplatin-induced chemotherapy retching She Moxing of rats was successfully replicated. The positive control group had a significant difference (P < 0.05) from example and an extremely significant difference (P < 0.01) from example 5 at 24 hours, as at 24 hours and 72 hours. That is, the positive control group had a significant difference (P < 0.05) from the example, and had an extremely significant difference (P < 0.01) from the example 5. See in particular figure 1.
1.6.2 statistics of feeding conditions in rats
After molding, the feed intake of the rats in each group injected with cisplatin was not substantially changed, and there was no statistically significant difference or significant difference between the groups. See in particular figure 2.
1.6.3 statistics of Water intake in rats
The water intake of each group of rats after molding was reduced and the model group showed the most remarkable, and the water intake of examples 1, 2 and 5 was significantly greater than that of the other comparative examples. By further analysis, the drinking water at 24h, 48h and 72h was found to have a significant difference in the group of example 5 compared to the positive control group. See in particular fig. 3.
1.6.4 rat weight change statistics
After molding, among the weights of the rats of each group injected with cisplatin, the weight of the rats of the model group decreased significantly, with a significant difference compared to the blank group. There was little change in the case of each group, and there was no statistically significant difference or significant difference between groups. See in particular figure 4.
2. Clinical application
1. Data and method
1.1 General data
56 pregnant vomiting patients who are collected and treated in 2021 month 12 to 2023 month 5 of our hospital are selected as study subjects, and are hospitalized patients, and are randomly divided into 28 treatment groups and 28 control groups. The mean age of the treatment group was 26.7.+ -. 5.6 years, and the course of the disease was 8.5.+ -. 3.4 days. The control group was aged 25.1.+ -. 8.7 years and had a course of 7.8.+ -. 3.2 days. The difference between the general data of the two groups of patients was not statistically significant (P > 0.05).
1.2 methods of treatment
The control group adopts conventional western medicine treatments such as fluid infusion and intramuscular injection sedation, namely, 100mg of vitamin B6 is mixed with 5% glucose solution and then is injected intravenously. The total treatment course is 1-2 weeks.
The treatment group was given an antiemetic paste (prepared according to the prescription and method described in example 5 above) and applied to the inner side of the wrist, once daily for 1-2 weeks as a total treatment course.
The two groups are treated and simultaneously give mental comfort to help patients eliminate doubts. Patients are ordered to rest in bed, and sufficient sleep is ensured. Meanwhile, the diet adjustment treatment is given to patients, and most of foods which are in line with the taste of the patients, rich in nutrition and easy to digest are given. Patients with serious illness are fasted for 1 day after admission.
1.3 efficacy assessment criteria
1.3.1 therapeutic effectiveness
And (3) curing: the vomiting is stopped, the symptoms are eliminated, and no repetition exists after stopping the medicine.
The method is effective: symptoms such as vomiting are relieved; or emesis is eliminated, but recurrence is also seen after stopping the drug.
Invalidation: the symptoms of vomiting are not improved.
Total effective rate= (cure number + effective number)/total number x 100%.
1.3.2 clinical symptom scoring
The disappearance of symptoms was 0 points; the symptoms are light, and the influence on work and life is not more than 1 minute; the symptoms are heavier, and the work and life are affected by 2 minutes; severe symptoms, no improvement was 3 points.
1.4 statistical methods
The related data are statistically analyzed by SPSS 22.0 software, the metering data are expressed as 'x+ -s', the t test is adopted, and the difference of P <0.05 is statistically significant.
2. Results
2.1 clinical effective rate
The total effective rate of the treatment group is 92.86%, which is significantly higher than that of the control group 67.86%, and the difference is significant.
Table 1 comparison of the effective rates of the clinical treatments of the groups
| Group of | Example number (example) | Cure (example) | Effective (example) | Invalidation (example) | Total effective rate (%) |
| Control group | 28 | 8 | 18 | 2 | 92.86 |
| Treatment group | 28 | 2 | 17 | 9 | 67.86 |
2.2 clinical symptom scoring
After the two groups of patients are treated, the clinical symptoms of nausea, vomiting, dizziness, anorexia, eating, vomiting and the like are obviously relieved, wherein the treatment group of patients is called a control group, the degree of relieving the symptoms is large, and the difference is statistically significant (P is less than 0.05).
Table 2 comparison of clinical symptom scores for groups
Note that: in contrast to the pre-treatment of this group, @ P＜0.05；
comparison with control group after treatment， △ P＜0.05。
Claims (10)
1. A Chinese medicinal composition containing folium Perillae, coptidis rhizoma, fructus Amomi, radix aucklandiae, rhizoma Pinelliae, rhizoma Zingiberis recens, rhizoma Dioscoreae and Mel is used for preventing and treating emesis.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises the following components:
40-100 parts of perilla leaf, 10-40 parts of coptis chinensis, 30-70 parts of fructus amomi,
20-50 parts of costustoot, 30-60 parts of pinellia ternate, 20-50 parts of ginger,
50-100 parts of yam and 50-150 parts of honey.
3. The traditional Chinese medicine composition according to claim 2, wherein the traditional Chinese medicine composition comprises the following components:
50-80 parts of perilla leaf, 20-35 parts of coptis root, 40-65 parts of fructus amomi,
30-40 parts of costustoot, 30-40 parts of pinellia ternate, 30-40 parts of ginger, and,
80-100 parts of yam and 80-120 parts of honey.
4. The traditional Chinese medicine composition according to claim 3, wherein the traditional Chinese medicine composition comprises the following components:
60 parts of perilla leaf, 25 parts of coptis chinensis, 45 parts of fructus amomi,
33 parts of costustoot, 33 parts of pinellia ternate, 33 parts of ginger, and,
80 parts of Chinese yam and 100 parts of honey.
5. The traditional Chinese medicine composition according to any one of claims 1 to 4, wherein the pinellia ternate is ginger processed pinellia ternate.
6. A method of preparing the traditional Chinese medicine composition of any one of claims 1-4, comprising the steps of:
1) Sieving Coptidis rhizoma powder with 20 mesh sieve, dissolving in 40-45deg.C hot water, maintaining temperature, and filtering with 80 mesh sieve.
2) Decocting the above materials except Mel in 6-12 times of water for 50-80 min, filtering, adding 4-8 times of water into the residue,
decocting for 40-60 min, filtering, mixing filtrates, concentrating at 70-80deg.C to relative density of 1.03-1.07, standing, collecting supernatant, adding Coptidis rhizoma powder fluid extract, concentrating at 70-80deg.C to relative density of 1.17-1.22, cooling, and standing to obtain paste;
3) Dissolving gelatin in water, uniformly mixing CMC-Na, PVP and sorbitol, adding into gelatin solution, adding 5% ethanol solution for full expansion, adding the paste and honey in the step 2), stirring, fully crosslinking, coating on non-woven fabrics, covering anti-sticking film, and drying to obtain the plaster.
7. The Chinese medicinal composition according to claim 1, wherein the emesis is emesis caused by a disease and/or a drug.
8. The use according to claim 7, wherein the vomiting is vomiting of pregnancy.
9. A Chinese medicinal preparation, which is prepared from the Chinese medicinal composition according to any one of claims 1 to 4.
10. The traditional Chinese medicine preparation according to claim 9, wherein the traditional Chinese medicine preparation is an oral preparation and/or an external preparation; preferably, the traditional Chinese medicine preparation is an external preparation; further preferably, the Chinese medicinal preparation is an external ointment.
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