CN104998162A - Medicine for treating cough and preparing method of medicine - Google Patents
Medicine for treating cough and preparing method of medicine Download PDFInfo
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Abstract
The invention discloses medicine for treating cough and a preparing method of the medicine. The medicine is mainly prepared from tartarian buckwheat root and rhizome, bunge hackberry bark or stem, Japanese metaplexis pericarp, fructus nandinae, dried tangerine or orange peel, lilies and cortex mori radicis according to a certain weight ratio. The medicine has the functions of relieving exterior syndrome, moistening dryness, moistening the lung, regulating qi, reducing phlegm and relieving a cough. When the medicine is used for treating the cough, the effect taking is fast, the curative effect is good, and the recurrence is avoided.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of cough and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Cough is one of common clinical symptoms of respiratory system, and mostly by respiratory tract disease, pleural diseases, cardiovascular disease etc. cause, and cough is then divided into internal injury, diseases caused by exogenous pathogenic factor two class by the traditional Chinese medical science, and wind and cold, heat, the exopathogen such as dry are attacked in lung, all can cause cough.Because western medicine cough side effect is large, therefore there is great demand in the Chinese medicine of people to effectively treatment cough, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment cough, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of effective treatment cough.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Rhizoma Fagopyri Cymosi, Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane), Pericarpium Metaplexis, Fructus Nandinae Domesticae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Herba Schizonepetae, the Radix Stemonae, Bulbus Lilii, Cortex Mori medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat cough.Wherein select a day Semen Fagopyri Esculenti root to be that have heat-clearing and toxic substances removing, the function of expelling wind and removing dampness, controls laryngopharynx swelling and pain, carbuncle skin ulcer scrofula, and muscles and bones is ached because its nature and flavor are bitter cold, wind syndrome of head is had a stomachache, bacillary dysentery.The function that Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane) has cough-relieving, eliminates the phlegm, controls chronic bronchitis.Pericarpium Metaplexis is selected to be because its nature and flavor are salty, flat, there is the function of removing heat from the lung and dissipating phlegm, control cough with copious phlegm, dyspnea and cough due to the lung-wind syndrome with phlegm, pertussis ， Jing Epilepsy, measles without adequate eruption.Fructus Nandinae Domesticae nature and flavor are sour, flat, and astringe the lung, cough-relieving, liver heat removing, the function of improving eyesight, controls chronic cough, pants, pertussis, malaria, and primary sore is festered.Pericarpium Citri Reticulatae is selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Herba Schizonepetae to be that temperature, enters lung, Liver Channel, deliver, dispel the wind, the function for the treatment of blood disorders because its nature and flavor are pungent, parch to black stops blooding, and cure cold heating, headache, laryngopharynx swelling and pain, apoplexy locked mouth, and spit blood, epistaxis, has blood in stool, metrorrhagia, puerperal blood faints, carbuncle, skin ulcer scabies, scrofula.The Radix Stemonae is selected to be that tepor, enters lung meridian, has gentle lung qi, cough-relieving, and the function of parasite killing, controls cough due to wind and cold, pertussis, pulmonary tuberculosis, old cough with asthma, ascarid, enterobiasis, skin scabies, eczema because its nature and flavor sweetness and bitterness.Select Bulbus Lilii to be because its property sweet and slightly bitter taste, flat, enter the heart, lung meridian, have nourishing the lung to arrest cough, the function of clearing away heart-fire for tranquillization, control pulmonary tuberculosis chronic cough, cough and spit expectorant blood, after calentura, waste heat is unclear, and fidgets due to deficiency is palpitated with fear, staring spells, beriberi edema.Select Cortex Mori to be that cold, enter lung, spleen channel, have eliminating pathogen from the lung for relieving asthma, the function of line water detumescence, controls dyspnea and cough due to lung-heat because its nature and flavor are sweet, spit blood, edema, beriberi, dysuria.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:
Rhizoma Fagopyri Cymosi 250-350 gram, Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane) 450-550 gram, Pericarpium Metaplexis 120-160 gram, Fructus Nandinae Domesticae 20-30 gram, Pericarpium Citri Reticulatae 120-160 gram, Radix Glycyrrhizae 80-100 gram, Herba Schizonepetae 120-160 gram, Radix Stemonae 100-150 gram, Bulbus Lilii 250-350 gram, Cortex Mori 120-180 gram.
Be preferably:
Rhizoma Fagopyri Cymosi 300 grams, Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane) 500 grams, Pericarpium Metaplexis 150 grams, Fructus Nandinae Domesticae 30 grams, Pericarpium Citri Reticulatae 150 grams, 90 grams, Radix Glycyrrhizae, Herba Schizonepetae 150 grams, the Radix Stemonae 120 grams, Bulbus Lilii 300 grams, Cortex Mori 150 grams.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Rhizoma Fagopyri Cymosi: the 10-11 month excavates, cleans, and section, dries;
2, Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane): cut summer and cut branch, takes advantage of fresh peeling, dries, or gets trunk flaking, dries;
3, Pericarpium Metaplexis: cut off fruit stem, removing seed and floss hair;
4, Fructus Nandinae Domesticae: during fruit maturation in autumn or gather spring next year, dries;
5, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;
6, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, run through, section, dries;
7, Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;
8, the Radix Stemonae: pick clean impurity, removing fibrous root, cleans, runs through rear cutting, dry;
9, Bulbus Lilii: pick decontamination, black lobe, ash disposal of winnowing with a dustpan is considered to be worth doing;
10, Cortex Mori: brush away ash bits, clean, run through rear shredding, dry.
Two, prepare
1, the preparation of medicament capsule of the present invention:
(1) Rhizoma Fagopyri Cymosi cooked, Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane), Pericarpium Metaplexis, Fructus Nandinae Domesticae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Herba Schizonepetae, the Radix Stemonae, Bulbus Lilii, Cortex Mori are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
(3) dry extract is broken into powder, incapsulates, every 0.5g.
2, the preparation of medicinal granule of the present invention:
(1) Rhizoma Fagopyri Cymosi cooked, Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane), Pericarpium Metaplexis, Fructus Nandinae Domesticae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Herba Schizonepetae, the Radix Stemonae, Bulbus Lilii, Cortex Mori are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
(3) dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule.
3, the preparation of medicinal tablet of the present invention:
(1) Rhizoma Fagopyri Cymosi cooked, Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane), Pericarpium Metaplexis, Fructus Nandinae Domesticae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Herba Schizonepetae, the Radix Stemonae, Bulbus Lilii, Cortex Mori are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
(3) dry extract is broken into fine powder, adds adjuvant and make granule, tabletted, every section of 0.5g.
In prescription, Pericarpium Metaplexis has the function of removing heat from the lung and dissipating phlegm, is monarch drug; Bulbus Lilii nourishing the lung to arrest cough, clearing away heart-fire for tranquillization; Pericarpium Citri Reticulatae has regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, and the two is ministerial drug, three taste medicines play lung moistening jointly, regulate the flow of vital energy, the effect of reducing phlegm, treatment cough effect is comprehensive, and with removing heat from the lung and dissipating phlegm, moistening dryness and relieve cough is that master can be effected a permanent cure, the Radix Stemonae has gentle lung qi, cough-relieving, and the function of parasite killing is adjuvant drug, Radix Glycyrrhizae and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription is for making medicine, and all medicines take stopgap measures with being left.
Medicine of the present invention has and induces sweat, and clearing away dryness, lung moistening, regulates the flow of vital energy, and reduces phlegm, and the function of cough-relieving, is used for the treatment of cough, short treating period, instant effect, non-relapse after healing.
Detailed description of the invention:
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group oral capsule, a kind of dosage form in granule or tablet is 0.2g/kg, and normal amount is 0.1g/kg, administering mode is the administration of dilution administration by gavage, twice daily, serve on 7 days, observe administration reaction every day, result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept cough out-patient totally 35 examples for medical treatment.
2, diagnostic criteria
Cough symptom is frequently or the cough of severity or Chen Faxing, and air of being afraid of cold is afraid of smog, and night increases the weight of.Along with aggravation can be coughed rapidly.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 4 grams, every day is early, middle and late respectively takes 1 time, within 8 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: cough transference cure, body constitution recovers normal, recovery from illness;
Take a turn for the better: patient's itching throat, severity cough phenomenon alleviates, cough symptom is clearly better;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy cough patients 35 example of the present invention, effective 31 examples of result, obvious effective rate is 88.57%, and take a turn for the better 3 examples, and improvement rate is 8.57%, and invalid 1 example, total effective rate is 97.14%.
Claims (3)
1. treat a medicine for cough, it is characterized in that: it is made up of the crude drug in following weight range:
Rhizoma Fagopyri Cymosi 250-350 gram, Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane) 450-550 gram, Pericarpium Metaplexis 120-160 gram, Fructus Nandinae Domesticae 20-30 gram, Pericarpium Citri Reticulatae 120-160 gram, Radix Glycyrrhizae 80-100 gram, Herba Schizonepetae 120-160 gram, Radix Stemonae 100-150 gram, Bulbus Lilii 250-350 gram, Cortex Mori 120-180 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Rhizoma Fagopyri Cymosi 300 grams, Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane) 500 grams, Pericarpium Metaplexis 150 grams, Fructus Nandinae Domesticae 30 grams, Pericarpium Citri Reticulatae 150 grams, 90 grams, Radix Glycyrrhizae, Herba Schizonepetae 150 grams, the Radix Stemonae 120 grams, Bulbus Lilii 300 grams, Cortex Mori 150 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Rhizoma Fagopyri Cymosi: the 10-11 month excavates, cleans, and section, dries;
(2) Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane): cut summer and cut branch, takes advantage of fresh peeling, dries, or gets trunk flaking, dries;
(3) Pericarpium Metaplexis: cut off fruit stem, removing seed and floss hair;
(4) Fructus Nandinae Domesticae: during fruit maturation in autumn or gather spring next year, dries;
(5) Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;
(6) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, run through, section, dries;
(7) Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;
(8) Radix Stemonae: pick clean impurity, removing fibrous root, cleans, runs through rear cutting, dry;
(9) Bulbus Lilii: pick decontamination, black lobe, ash disposal of winnowing with a dustpan is considered to be worth doing;
(10) Cortex Mori: brush away ash bits, clean, run through rear shredding, dry;
(2) prepare
(1) preparation of medicament capsule of the present invention:
1. the Rhizoma Fagopyri Cymosi cooked, Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane), Pericarpium Metaplexis, Fructus Nandinae Domesticae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Herba Schizonepetae, the Radix Stemonae, Bulbus Lilii, Cortex Mori are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
2. filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
3. dry extract is broken into powder, incapsulates, 0.5 gram every;
(2) preparation of medicinal granule of the present invention:
1. the Rhizoma Fagopyri Cymosi cooked, Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane), Pericarpium Metaplexis, Fructus Nandinae Domesticae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Herba Schizonepetae, the Radix Stemonae, Bulbus Lilii, Cortex Mori are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
2. filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
3. dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule;
(3) preparation of medicinal tablet of the present invention:
1. the Rhizoma Fagopyri Cymosi cooked, Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane), Pericarpium Metaplexis, Fructus Nandinae Domesticae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Herba Schizonepetae, the Radix Stemonae, Bulbus Lilii, Cortex Mori are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
2. filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
3. dry extract is broken into fine powder, adds adjuvant and make granule, tabletted, every sheet 0.5 gram.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510562390.6A CN104998162A (en) | 2015-09-08 | 2015-09-08 | Medicine for treating cough and preparing method of medicine |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105519812A (en) * | 2016-01-01 | 2016-04-27 | 闫冷 | Chick infectious broncheitis treatment feed additive |
| CN105533252A (en) * | 2016-01-01 | 2016-05-04 | 闫冷 | Feed additive for treating paratyphoid fever of chickens |
| CN105796830A (en) * | 2016-04-19 | 2016-07-27 | 王刚 | Traditional Chinese medicine for treating sinobronchiales syndrome |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101496881A (en) * | 2009-01-22 | 2009-08-05 | 张磊 | Syrup for suppressing cough and preparation method |
| CN101940766A (en) * | 2010-10-13 | 2011-01-12 | 许文成 | Medicine for radically curing myocardial infarction and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496881A (en) * | 2009-01-22 | 2009-08-05 | 张磊 | Syrup for suppressing cough and preparation method |
| CN101940766A (en) * | 2010-10-13 | 2011-01-12 | 许文成 | Medicine for radically curing myocardial infarction and preparation method thereof |
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| 余瀛鳌主编: "《内科通治方》", 31 January 2010, 中国医药科技出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105519812A (en) * | 2016-01-01 | 2016-04-27 | 闫冷 | Chick infectious broncheitis treatment feed additive |
| CN105533252A (en) * | 2016-01-01 | 2016-05-04 | 闫冷 | Feed additive for treating paratyphoid fever of chickens |
| CN105796830A (en) * | 2016-04-19 | 2016-07-27 | 王刚 | Traditional Chinese medicine for treating sinobronchiales syndrome |
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Application publication date: 20151028 |