CN107213205B - Medicine and food formula for specific endowment constitution of children - Google Patents
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- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
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- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The invention belongs to the field of medicine and food, and particularly relates to a medicine and food formula for specific endowment constitution of children. The composite material is prepared from the following raw materials in parts by weight: 3-9 parts of perilla leaf, 3-9 parts of perilla seed, 3-9 parts of perilla stem, 6-15 parts of poria cocos, 6-10 parts of eupatorium, 2-6 parts of sea buckthorn, 2-9 parts of lotus leaf and 5-10 parts of mint leaf (fried). The Chinese medicinal composition has the advantages of low raw material cost, convenient use, practicality, effective yin and yang balancing, viscera conditioning and no toxic or side effect.
Description
Technical Field
The invention belongs to the field of medicine and food, and particularly relates to a medicine and food formula for specific endowment constitution of children.
Background
The idiosyncratic constitutions refer to a specific constitution formed on the basis of the innate inheritance, under the action of external factors, the physiological functions and self-adaptive ability are low, the reactivity is enhanced, and the sensitivity tendency is shown as the affinity and reactivity to different allergens, which shows the difference of individual constitutions and the tendency of family aggregation. The key characteristics of the traditional Chinese medicine are that the adaptability to the external environment is poor, people with allergic constitution can generate various allergic reactions and allergic diseases, and sometimes the same patient can suffer from various allergic diseases.
The traditional Chinese medicine considers that the formation mechanism of the specific endowment constitution is yin-yang imbalance, and children are easy to have yin-yang imbalance compared with adults, and allergic diseases such as obesity, eczema, urticaria, allergic rhinitis and allergic asthma are caused. At present, western medicine treatment is mainly specific treatment aiming at etiology and non-specific prevention method aiming at anaphylactic reaction, but the treatment has the defects that specific anaphylactic etiology is difficult to determine, desensitization antigen cannot cover all anaphylactic substances, side effect is large, failure is easy to occur and the like, so that clinical application is greatly limited. The traditional Chinese medicine has better curative effect on conditioning specific endowment constitution. Therefore, the medicine and food formula research and development aiming at the children with specific endowment constitution has important significance.
Disclosure of Invention
Aiming at the problems, the invention aims to provide a medicine and food formula for regulating the specific endowment constitution of children, which has the advantages of low raw material cost, convenient and practical use, effective yin and yang balance, viscera conditioning and no toxic or side effect.
In order to achieve the purpose, the invention provides a medicine and food formula for the specific endowment constitution of children, which is prepared from the following raw materials in parts by weight: 3-9 parts of perilla leaf, 3-9 parts of perilla seed, 3-9 parts of perilla stem, 6-15 parts of poria cocos, 6-10 parts of eupatorium, 2-6 parts of sea buckthorn, 2-9 parts of lotus leaf and 5-10 parts of mint leaf (fried).
The preparation method of the medicinal and edible formula for the specific endowment constitution comprises the following steps.
Step 1, pretreatment: the materials are received according to the production instruction, the code, name, specification, number, weight and the like of the materials are checked, and coat removal and disinfection are carried out.
Step 2, granulating: taking the following raw materials according to the formula proportion: folium Perillae, fructus Perillae, caulis Perillae, Poria, herba Eupatorii, fructus Hippophae, folium Nelumbinis, and folium Menthae (parched), and granulating in mixing granulator.
And step 3, drying: after granulation, drying treatment is carried out, and the drying temperature is controlled to be 35-40 ℃.
Step 4, straightening granules: and (4) granulating the dried material in a granulator.
Step 5, mixing and filling: and (4) adding auxiliary materials such as lactose, compressible starch, aerosil and the like into the material after the whole grain in the step (4), uniformly mixing in a mixer, and then packaging on an automatic packaging machine.
Step 6, thermal shrinkage: and (4) beating the prepared small packaged product for a corresponding production date, and sleeving a heat shrinkage film for heat shrinkage.
Step 7, metal detection: and (4) placing the product subjected to heat shrinkage on a food metal detector for detection, and then packaging and packaging to obtain a finished product.
And step 8, warehousing: and placing the finished product into a product qualified area of a storehouse.
The medicinal and edible formula for the specific endowment constitution can be prepared into drinks, foods, medicines and the like.
The invention analyzes the drug properties of the raw materials.
Perilla seed in the whole plant of Perilla frutescens is pungent and warm, enters lung and large intestine channels, lowers qi, reduces phlegm, relieves cough and asthma, and moistens the intestines to relieve constipation; perilla leaf and perilla stem, pungent and warm, enter lung and spleen meridians and regulate qi to relieve middle energizer.
Tuckahoe, poria cocos: sweet, bland and neutral, enter heart, spleen and kidney meridians, induce diuresis and permeate, invigorate spleen and soothe nerves.
Herba Eupatorii: pungent and mild in flavor and enter spleen, stomach and lung meridians, resolve dampness and relieve summer-heat.
Sea-buckthorn: sour and astringent; warm, relieving cough and reducing sputum, invigorating stomach and promoting digestion, activating blood and dissipating blood stasis.
Lotus leaf: bitter, sweet and mild, and has the effects of clearing away heart-fire, relieving summer-heat, removing blood stasis, stopping bleeding, dispelling pathogenic wind and eliminating dampness. Mint leaf: pungent and cool, entering lung and liver meridians, disperse wind-heat, clear heat and eyes, relieve sore throat and promote eruption, and soothe liver.
The invention has remarkable effect.
The prescription of the invention is compatible and release: the constitutional constitutions are usually formed in childhood and related to lung and spleen. Frequent insufficiency of lung and frequent insufficiency of spleen in children; when lung qi is damaged and spleen fails to transport body fluid, fluid stays due to spleen deficiency and transportation failure, pathological products such as dampness, phlegm and fluid are produced and stored in the body to form perennial root, or stagnates in skin, or is stored in lung, and allergic diseases occur after being triggered by allergen, so that spleen-invigorating, dampness-removing, phlegm-eliminating, orifice-dredging and itching-relieving herbs should be given.
The formula analysis in the formula: perilla seed in the whole plant of Perilla frutescens is pungent and warm, enters lung and large intestine channels, lowers qi, reduces phlegm, relieves cough and asthma, and moistens the intestines to relieve constipation; the perilla leaves and perilla stems are pungent and warm, enter lung channels and spleen channels, regulate qi and relieve epigastric distention, and are monarch drugs, and modern pharmacological studies show that the perilla has obvious antiallergic effect; poria cocos, sweet, bland and flat, enters heart, spleen and kidney channels, promotes diuresis and permeates, invigorates spleen and calms nerves, herba Eupatorii, pungent and flat, enters spleen, stomach and lung channels, and dissipates dampness, and is used as a ministerial drug; the sea-buckthorn, the lotus leaves and the mint leaves are used as adjuvant medicines, wherein the sea-buckthorn is used for reducing phlegm and invigorating stomach and is used for eating less; the lotus leaves dispel dampness, and modern pharmacological research shows that the lotus leaves have obvious lipid-lowering effect and are suitable for obese children; the mint leaves are good at clearing head and eyes, and relieving sore throat and promoting eruption, which are set for nasal itching and throat itching. The whole formula exerts the effects of invigorating spleen, eliminating dampness, eliminating phlegm, dredging orifices and relieving itching together.
The viscera of children are delicate, the body shape and qi are not sufficient, and the metabolism function of the organism to the medicine is weak, so the raw materials used by the medicine formula are all from the national medical and edible dual-purpose catalogue, are safe and non-toxic, are suitable for children, can effectively make up the efficacy limitation of single-component food, have obvious effect on the specific endowment constitution of the children in clinical application, and have potential social benefit and economic benefit.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1.
A medicine and food formula for specific endowment constitution of children is composed of the following raw materials in parts by weight: 9 parts of perilla leaf, 8 parts of perilla seed, 7 parts of perilla stem, 10 parts of tuckahoe, 10 parts of eupatorium, 5 parts of sea buckthorn, 8 parts of lotus leaf and 9 parts of mint leaf (fried).
The preparation method of the medicinal and edible formula for the specific endowment constitution comprises the following steps.
Step 1, pretreatment: the materials are received according to the production instruction, the code, name, specification, number, weight and the like of the materials are checked, and coat removal and disinfection are carried out.
Step 2, granulating: taking the following raw materials according to the formula proportion: folium Perillae, fructus Perillae, caulis Perillae, Poria, herba Eupatorii, fructus Hippophae, folium Nelumbinis, and folium Menthae (parched), and granulating in mixing granulator (particle size can be adjusted according to clinical requirement).
And step 3, drying: after the granulation, drying treatment was performed, and the drying temperature was controlled at 40 ℃.
Step 4, straightening granules: and (4) granulating the dried material in a granulator.
Step 5, mixing and filling: and (4) adding lactose, compressible starch and superfine silica gel powder into the material after the whole grain in the step (4), uniformly mixing in a mixer, and then packaging on an automatic packaging machine.
Step 6, thermal shrinkage: and (4) beating the prepared small packaged product for a corresponding production date, and sleeving a heat shrinkage film for heat shrinkage.
Step 7, metal detection: and (4) placing the product subjected to heat shrinkage on a food metal detector for detection, and then packaging and packaging to obtain a finished product.
And step 8, warehousing: and placing the finished product into a product qualified area of a storehouse.
Example 2.
A medicine and food formula for specific endowment constitution of children is composed of the following raw materials in parts by weight: 8 parts of perilla leaf, 9 parts of perilla seed, 9 parts of perilla stem, 15 parts of poria cocos, 9 parts of eupatorium fortunei, 6 parts of sea buckthorn, 9 parts of lotus leaf and 6 parts of mint leaf (fried).
Example 3.
A medicine and food formula for specific endowment constitution of children is composed of the following raw materials in parts by weight: 3 parts of perilla leaf, 3 parts of perilla seed, 3 parts of perilla stem, 6 parts of tuckahoe, 6 parts of eupatorium, 2 parts of sea buckthorn, 2 parts of lotus leaf and 5 parts of mint leaf (fried).
Example 4.
A medicine and food formula for specific endowment constitution of children is composed of the following raw materials in parts by weight: 8 parts of perilla leaf, 6 parts of perilla seed, 9 parts of perilla stem, 9 parts of tuckahoe, 10 parts of eupatorium, 6 parts of sea buckthorn, 9 parts of lotus leaf and 10 parts of mint leaf (fried).
Example 5.
A medicine and food formula for specific endowment constitution of children is composed of the following raw materials in parts by weight: 9 parts of perilla leaf, 9 parts of perilla seed, 9 parts of perilla stem, 9 parts of tuckahoe, 7 parts of eupatorium, 6 parts of sea buckthorn, 8 parts of lotus leaf and 6 parts of mint leaf (fried).
1. Clinical data.
1.1 general data: 300 cases are children with specific endowment constitution, and are randomly divided into two groups, namely a control group and an experimental group. 150 patients in the control group and 150 patients in the experimental group have no significant difference in terms of age, sex and the like through statistical analysis and are comparable.
1.2 methods of treatment.
Treatment groups: the formulation of example 1 was administered orally, for a period of 1 month; control group: pidotimod oral liquid.
1.3 evaluation criteria of curative effect: refer to the guideline of clinical research of new Chinese medicine.
The clinical cure is as follows: the symptoms completely disappear, the main physical and chemical inspection indexes are normal, and the curative effect indexes are all more than or equal to 95 percent; the effect is shown: the main symptoms disappear, the main physical and chemical inspection indexes are basically normal, and the curative effect index is 70-94%; the method has the following advantages: the main symptoms basically disappear, the main physical and chemical indexes are improved, and the curative effect index is 30-69 percent; and (4) invalidation: compared with the treatment before, all aspects are not improved, and the curative effect index is less than 30 percent.
The formula (nimodipine method) for calculating the curative effect index is as follows: [ (pre-treatment score-post-treatment score)/pre-treatment score ] × 100%.
1.4 statistical analysis: adopting SPSS19.0 software package for statistics, and adopting X for counting data2And (4) testing, wherein the curative effect index is processed by a t-test statistical method.
1.5 treatment outcome.
1.5.1 the clinical effects of the two groups are compared, and are shown in Table 1.
Table 1 statistics of clinical efficacy of treatment groups and control groups.
The total curative effects of the two groups are statistically processed, the total effective rate has significant difference, and P is less than 0.05.
1.5.2 evaluation of safety.
The safety evaluation mainly comprises anaphylactic reaction, anaphylactic shock, rash, digestive system symptoms such as nausea, vomit and diarrhea, respiratory system symptoms such as cough, chest distress and breathlessness, drug fever, death caused by anaphylaxis and the like.
During the research period, the treatment group has no adverse events such as anaphylactic reaction, anaphylactic shock, rash, digestive system symptoms such as nausea, vomit and diarrhea, respiratory system symptoms such as cough, chest distress and short breath, drug fever and death caused by allergy.
Therefore, after two groups of patients are treated, the curative effect of the treatment group is superior to that of the control group, and the patients adopting the medicinal and edible formula have better curative effect, can effectively improve the physique of children and improve the life quality of the patients.
2. Typical cases.
Patient 1, Dongqi, woman, 6 years old. The doctor visits 5 and 9 days in 2016, and parents complain that the infant plain often sneezes and has nasal discharge, cough, dry cough, no phlegm, paroxysmal property, easy allergy in spring, easy pruritus of skin, red skin after scratching and scratch when smelling peculiar smell in seasons and temperature changes. The infant suffers from eczema and urticaria. Physical examination: the mind is clear and the spirit is clear, allergic eye shadow can be seen, lip red and abnormal heart and lung diagnosis and abnormal body examination of the nervous system can be seen. The infant constitution in this example is considered as the specific constitution. The formulation of example 1 was administered by decoction 1 time a day for 1 month. The symptoms of the sick children are disappeared after the repeated diagnosis of 2016, 6, 9 and the allergic eye shadow of the physical examination eyes is disappeared.
Patient 2, von, male, 10 years old. The doctor visits 8 and 22 days in 2016, and parents of the infant suffer from cough, dry cough, no phlegm, paroxysmal, frequent sneezing, easy allergy in spring and easy skin pruritus when the infant falls out of plain season or smells peculiar smell. The infant suffers from eczema and urticaria. Physical examination: the mind is clear and the spirit is clear, allergic eye shadow can be seen, lip red and abnormal heart and lung diagnosis and abnormal body examination of the nervous system can be seen. The infant constitution in this example is considered as the specific constitution. The formulation of example 1 was administered by decoction 1 time a day for 1 month. The symptoms of the children are disappeared after the 8-29-day reexamination in 2016, and the allergic eye shadow of the physical examination eyes disappears.
Patient 3, lie, woman, 5 years old. The doctor visits the infant at 26 months 5 in 2016, and parents complain that the infant is easy to be allergic recently, the skin itch is obvious, and the infant suffers from cough, dry cough, no phlegm, paroxysmal property and frequent sneezing in climatic change when smelling peculiar smell. The infant had suffered from eczema. Physical examination: the mind is clear and the spirit is clear, allergic eye shadow can be seen, lip red and abnormal heart and lung diagnosis and abnormal body examination of the nervous system can be seen. The infant constitution in this example is considered as the specific constitution. The formulation of example 2 was administered by decoction 1 time a day for 1 month. The symptoms of the children are disappeared after the 29 th 6 th month in 2016, and the allergic eye shadow of the physical examination eyes disappears.
Patient 4, forest, male, 6 years old. The doctor visits the affected infant in 2016 at 5/12 days, and the parents complain that the infant coughs, dry cough, no phlegm, paroxysmal nature, frequent sneezing and nasal discharge when the infant smells peculiar smell, allergic reaction in spring, skin pruritus, red skin after being grabbed by the head and scratch. The infant suffers from eczema and urticaria. Physical examination: the mind is clear and the spirit is clear, allergic eye shadow can be seen, lip red and abnormal heart and lung diagnosis and abnormal body examination of the nervous system can be seen. The infant constitution in this example is considered as the specific constitution. The formulation of example 3 was administered by decoction 1 time a day for 1 month. The symptoms of the sick children are disappeared after the repeated diagnosis of 2016, 6 and 13 days, and the allergic eye shadow of the physical examination eyes is disappeared.
Patient 5, marmot, male, 6 years old. The doctor visits the patient 2 and 13 days in 2016, and parents complain that the skin of the patient turns red as soon as the patient catches the skin, and the patient usually sneezes and has nasal discharge, cough, dry cough, no phlegm, paroxysmal property, easy allergy in spring and easy pruritus of the skin when the patient smells peculiar smell or changes seasons and temperature. The infant suffers from eczema and urticaria. Physical examination: the mind is clear and the spirit is clear, allergic eye shadow can be seen, lip red and abnormal heart and lung diagnosis and abnormal body examination of the nervous system can be seen. The infant constitution in this example is considered as the specific constitution. The formulation of example 4 was administered by decoction 1 time a day for 1 month. The symptoms of the sick children are disappeared after the 3-13-day follow-up diagnosis in 2016, and the allergic eye shadow of the physical examination eyes is disappeared.
Claims (6)
1. A medicine and food formula for specific endowment constitution of children is characterized by comprising the following raw materials in parts by weight: 3-9 parts of perilla leaves, 3-9 parts of perilla seeds, 3-9 parts of perilla stems, 6-15 parts of poria cocos, 6-10 parts of eupatorium, 2-6 parts of sea buckthorn, 2-9 parts of lotus leaves and 5-10 parts of fried thin lotus leaves.
2. The pharmaceutical and edible formulation for the specific endowment constitution of children as claimed in claim 1, wherein the raw materials comprise: 9 parts of perilla leaf, 8 parts of perilla seed, 7 parts of perilla stem, 10 parts of poria cocos, 10 parts of eupatorium, 5 parts of sea buckthorn, 8 parts of lotus leaf and 9 parts of fried thin lotus leaf.
3. The pharmaceutical and edible formula for the intrinsic constitution of children according to claim 1, characterized by comprising the following raw materials in parts by weight: 8 parts of perilla leaf, 9 parts of perilla seed, 9 parts of perilla stem, 15 parts of poria cocos, 9 parts of eupatorium, 6 parts of sea-buckthorn, 9 parts of lotus leaf and 6 parts of fried thin lotus leaf.
4. The pharmaceutical and edible formula for the intrinsic constitution of children according to claim 1, characterized by comprising the following raw materials in parts by weight: 3 parts of perilla leaves, 3 parts of perilla seeds, 3 parts of perilla stems, 6 parts of poria cocos, 6 parts of eupatorium, 2 parts of sea-buckthorn, 2 parts of lotus leaves and 5 parts of fried thin lotus leaves.
5. The pharmaceutical and edible formulation for children's intrinsic constitution according to claim 1, wherein the formulation comprises 8 parts of perilla leaf, 6 parts of perilla seed, 9 parts of perilla stem, 9 parts of poria cocos, 10 parts of eupatorium, 6 parts of sea buckthorn, 9 parts of lotus leaf, and 10 parts of fried thin lotus leaf.
6. The pharmaceutical and edible formulation for children's intrinsic constitution according to claim 1, wherein 9 parts of perilla leaf, 9 parts of perilla seed, 9 parts of perilla stem, 9 parts of poria cocos, 7 parts of eupatorium, 6 parts of sea buckthorn, 8 parts of lotus leaf, and 6 parts of fried thin lotus leaf.
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