CN114073730A

CN114073730A - Traditional Chinese medicine composition for preventing or treating air-conditioning syndrome

Info

Publication number: CN114073730A
Application number: CN202010815580.5A
Authority: CN
Inventors: 程国良; 李冰冰
Original assignee: Lunan Pharmaceutical Group Corp
Current assignee: Lunan Pharmaceutical Group Corp
Priority date: 2020-08-14
Filing date: 2020-08-14
Publication date: 2022-02-22

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating air-conditioning syndrome. The traditional Chinese medicine composition is mainly prepared from notopterygium root, radix angelicae pubescentis, poria cocos, divaricate saposhnikovia root, schizonepeta, ligusticum wallichii, platycodon grandiflorum, radix bupleuri, radix peucedani, fructus aurantii and liquorice. The traditional Chinese medicine composition has obvious effects of resisting inflammation, easing pain, relieving cough, sweating and relieving fever, and can also effectively treat diarrhea caused by air-conditioning diseases; can be clinically used for treating the air-conditioning syndrome and has obvious effect.

Description

Traditional Chinese medicine composition for preventing or treating air-conditioning syndrome

Technical Field

The invention relates to a composition, in particular to a traditional Chinese medicine composition for preventing or treating air-conditioning syndrome, and belongs to the technical field of traditional Chinese medicines.

Background

The air conditioning syndrome is also called as air conditioning disease, and refers to a series of syndromes caused by the fact that the environment cannot be improved due to the fact that air does not circulate and the low-temperature environment of an air-conditioned room stimulates the body when people work and live in the air-conditioned environment for a long time.

"air conditioning disease" is a modern disease, but is not a real disease in medicine. The discomfort habits are collectively called "air conditioning diseases" simply because a lot of discomfort occurs to people after air conditioning.

The manifestations of "air conditioning diseases" are different depending on the constitution of each person, and they are usually easy to attack the respiratory tract, joint muscles, skin and nervous system of the person. When the skin is affected, dry skin, pruritus, erythema and the like can appear; if it affects the respiratory tract, it manifests as upper respiratory tract symptoms such as cough, sneeze, and nasal discharge, and serious lower respiratory tract problems such as pneumonia; when the gastrointestinal tract is affected, the symptoms of anorexia, abdominal pain, diarrhea, nausea, vomiting and the like can be presented; if the muscle and joint is cold, pain or stiffness of waist, back and joint, muscle soreness, etc. can occur; facial neuritis and local peripheral neuritis of the skin may also be symptoms of "air conditioning disease", and facial distortion may also occur in severe cases. Women often blow air, and the diseases such as irregular menstruation, dysmenorrheal and the like can also be caused.

The 'air conditioning diseases' are not caused by catching a cold, and many people think that the 'air conditioning diseases' are caused by blowing air and catching a cold, which is just one reason. The incidence of air conditioning diseases is also related to factors such as indoor temperature, anion concentration, microorganism conditions, human physique and psychological state and the like. For example, in the case of an air conditioner, the temperature is set to be too low, the temperature difference between the inside and the outside is large, and the human body is likely to feel uncomfortable. The nerve regulation function is easy to be disordered at low temperature, the sympathetic nerve can be excited by large indoor and outdoor temperature difference, and the blood vessel in the abdominal cavity is contracted, so that the gastrointestinal motility is weakened, or the body surface blood vessel is contracted, the blood flow is not smooth, and the arthralgia is caused; when the air conditioner is started, the humidity of a room is reduced, the skin feels uncomfortable in the environment for a long time, the mucous membrane of the nasal cavity is too dry, the resistance of a human body is reduced, and germs and viruses can be given opportunity; when the air conditioner is opened, people are used to close doors and windows, so that the room is high in airtightness, poor in air fluidity, insufficient in sunlight and easy to breed pathogenic microorganisms; when the air conditioner is started, pathogenic bacteria and viruses deposited on air conditioning equipment and pipelines are easily blown into a room, so that the pathogenic bacteria in the air are increased, and diseases are easily induced; negative ions in the air can actively regulate the functions of the central nervous system and cerebral cortex, improve the function of pulmonary ventilation, enhance the immunity of the organism, promote the synthesis of various vitamins in the body and the like, but in some air conditioners, a large amount of negative ions are adsorbed, positive ions are relatively increased, the proportion of negative ions and positive ions is disordered, and the normal functions of the human body are influenced.

Considering from the aspect of traditional Chinese medicine etiology, the diseases mainly occur in summer, summer-heat is in due order, summer-heat is yang pathogen, the property of the disease belongs to fire, and wang menying of warm pathologist indicates in damp-heat longitude and latitude: "summer-heat makes damp exuberant and must be accompanied by much sensation". Because the air conditioner artificially creates wind and cold pathogens to influence the normal clearing and dispersing of the pathogenic factors of summer-heat and dampness, when a human body is in or goes in the air conditioning environment for a long time, the human body is hot and cool at first glance, the skin is hollow and loose, and the pathogens invade to cause diseases, and the syndrome factors mainly comprise the reasons of wind, cold, summer-heat, dampness and deficiency. When the pathogenic factors are stagnated on the body surface of the skin, dizziness, headache and joint wandering pain are caused, the yang qi of people is most easily injured by cold pathogen, and the defensive yang of the exterior is injured, so that the symptoms of intolerance of cold, ache all over the body, no sweating or hypohidrosis can be caused, and the initial syndrome is mainly of the exterior cold stagnated heat type. If the treatment is missed or mishandled, the syndrome of exogenous pathogenic factors entering the interior to transform into heat or injuring the stomach-yang will manifest as severe fever, abdominal distension and diarrhea, nausea and vomiting, tasteless eating, etc., so the pattern of this stage is mainly summer-heat with dampness. The pathogenic summer-heat and dampness easily consume qi and injure the body fluids, and the summer-heat blocks qi movement, impairs middle-jiao energy and original qi, so the symptoms of fever, sweating, thirst, anorexia, lassitude and hypodynamia are commonly seen in the later stage of the disease, so the syndrome of this stage is mainly qi-yin deficiency syndrome.

Therefore, from the perspective of traditional Chinese medicine, the pathogenic factors of the air conditioner are mainly "cold" and "summer-heat and dampness". Cold attacking the exterior, causing the stagnation of defensive qi, manifested as aversion to cold, nasal obstruction, runny nose, cough, itching throat, thin and white sputum. Pathogenic qi entering the interior can injure the spleen and stomach, and excessive dampness in summer can cause stagnation of dampness in the spleen and stomach manifested as poor appetite, diarrhea, abdominal pain, etc. Cold stagnation and unsmooth circulation of qi and blood can also lead to chest stuffiness and cardiodynia, especially for cardiovascular diseases.

The observation of the efficacy of Jingfang Baidu san plus-minus for treating air-conditioning cold-air syndrome recorded in the article A, the air-conditioning cold-air syndrome is added and subtracted according to the category of wind-cold type common cold identified by the traditional Chinese medicine, namely Jingfang, ledebouriella root, notopterygium root, Ligusticum wallichii, pubescent angelica root each 10g, poria cocos wolf 15g, root of ballon flower, licorice root each 10g, cassia twig 10g, wrinkled gianthyssop 15g (namely, bupleurum root, peucedanum root, bitter orange are removed from the Jingfang Baidu san prescription); 15g of radix cynanchi stauntonii and 15g of almond respectively and 10g of bulbus fritillariae cirrhosae are added for treating cough and expectoration; 30g of raw astragalus, 15g of fried bighead atractylodes rhizome and 10g of Chinese magnoliavine fruit are added for treating exterior deficiency. The results show that the patients who suffer from wind-cold-like exogenous pathogens caused by cold air of the air conditioner have poor treatment effect compared with the patients who suffer from the wind-cold-like exogenous pathogens in the nature; whether the treatment of the 'air-conditioning cold air syndrome' can be separated from the environment of air-conditioning cold air or not is of great importance to the curative effect of patients of the type, the cure rate is greatly improved if the treatment is good, and otherwise, the patients are difficult to cure.

Disclosure of Invention

The inventor explains that the invention is further developed on the basis of the existing product 'Jingfang granules', and the new application of the Jingfang granules comes from feedback after clinical use of doctors. When the clinician feeds back, the patient suffering from the disease due to the cold air of the air conditioner is treated by the wind-cold type cold, and after some patients with complex symptoms take the Jingfang granules, the cold symptoms such as fever, nasal obstruction, watery nasal discharge and the like are obviously relieved, and the gastrointestinal symptoms such as diarrhea, retching and the like are also obviously relieved.

Based on the clinical use feedback, the inventor further researches and develops the Jingfang granules and the prescription thereof on the new application of treating the 'air conditioning syndrome'.

One of the purposes of the invention is to provide a traditional Chinese medicine composition for treating air-conditioning syndrome, which is mainly prepared from notopterygium root, radix angelicae pubescentis, poria cocos, radix sileris, schizonepeta, ligusticum wallichii, platycodon grandiflorum, radix bupleuri, radix peucedani, fructus aurantii and liquorice; the traditional Chinese medicine composition provided by the invention can effectively relieve or eliminate cold symptoms such as nasal obstruction, watery nasal discharge and the like of patients with air-conditioning syndrome, and can also treat or relieve clinical symptoms such as diarrhea, vomiting, joint pain and the like.

The air-conditioning syndrome of the invention is a series of syndromes, and the clinical manifestations mainly comprise cold symptoms, gastrointestinal tract symptoms, joint symptoms and other symptoms.

Specifically, the clinical manifestations of the air-conditioning syndrome include but are not limited to cough, sneeze, nasal obstruction, watery nasal discharge, fever, aversion to cold, hypodynamia, dizziness, headache, pharyngalgia and other cold symptoms.

Clinical manifestations of the air conditioning syndrome of the present invention include but are not limited to skin symptoms such as dry skin, itching, erythema, and tightness.

The clinical manifestations of the air conditioning syndrome include but are not limited to gastrointestinal symptoms such as anorexia, abdominal pain, diarrhea, nausea, vomiting, etc.

The clinical manifestations of the air conditioning syndrome include but are not limited to symptoms such as pain or stiffness of waist and back joints, muscle soreness and the like.

The clinical manifestations of the air conditioning syndrome include but are not limited to facial neuritis, local peripheral neuritis and other symptoms.

The second purpose of the present invention is to provide the specific composition of the above traditional Chinese medicine composition, namely, the traditional Chinese medicine composition is mainly prepared from the following raw materials:

preferably, the traditional Chinese medicine composition is mainly prepared from the following raw materials:

in a further preferred scheme, the traditional Chinese medicine composition is mainly prepared from the following raw materials:

in a further preferred embodiment, the Chinese medicinal composition is prepared from the following raw materials:

the invention also aims to provide a preparation method of the traditional Chinese medicine composition, which mainly comprises the following steps:

step A: distilling herba Schizonepetae, radix Saposhnikoviae, Notopterygii rhizoma, radix Angelicae Pubescentis, radix Peucedani, rhizoma Ligustici Chuanxiong, and fructus Aurantii to obtain volatile oil, and collecting the residue, rhizoma Ligustici Chuanxiong, and fructus Aurantii water solution;

and B: b, preparing the distilled water solution of the ligusticum wallichii and the fructus aurantii obtained in the step A into a 10-40% ethanol solution for later use;

and C: mixing Poria, the distilled rhizoma Ligustici Chuanxiong obtained in step A, and fructus Aurantii residue, percolating with the ethanol solution obtained in step B, and collecting percolate;

step D: decocting radix bupleuri, platycodon grandiflorum, liquorice, the distilled schizonepeta obtained in the step A, divaricate saposhnikovia root, notopterygium root, radix angelicae pubescentis and radix peucedani dregs in water, and concentrating the decoction for later use;

step E: and D, mixing the percolate obtained in the step C and the decoction obtained in the step D, concentrating, and adding the volatile oil obtained in the step A to obtain the composition.

Preferably, the preparation method mainly comprises the following steps:

and B: preparing the distilled water solution of the ligusticum wallichii and the bitter orange obtained in the step A into 15-30% ethanol solution for later use;

step D: decocting radix bupleuri, platycodon grandiflorum, liquorice, the distilled schizonepeta obtained in the step A, divaricate saposhnikovia root, notopterygium root, radix angelicae pubescentis and radix peucedani dregs in water, and concentrating the decoction into thick paste for later use;

step E: and D, mixing the percolate obtained in the step C and the thick paste obtained in the step D, concentrating the mixture into clear paste, and adding the volatile oil obtained in the step A to obtain the ointment.

Further preferably, the preparation method mainly comprises the following steps:

and B: b, preparing the distilled water solution of the ligusticum wallichii and the fructus aurantii obtained in the step A into a 25% ethanol solution for later use;

The fourth purpose of the invention is to provide a Chinese medicinal preparation containing the Chinese medicinal composition, wherein the Chinese medicinal preparation is a clinically acceptable oral preparation;

preferably, the clinically acceptable oral preparation is one or more of pills, capsules, tablets, granules or liquid oral preparations;

even more preferably, the oral formulation is a granule.

The invention also provides application of the Jingfang granules in preparing a medicine for treating and/or preventing the air-conditioning syndrome.

Compared with the prior art, the invention has the following remarkable technical effects:

1. pharmacological experiments show that the traditional Chinese medicine composition can reduce the diarrhea mouse loose stool rate and loose stool level caused by senna leaves, and obviously reduce the mouse loose stool index.

2. Clinical research results show that the symptoms of the patients with the air-conditioning syndrome treated by the traditional Chinese medicine composition disappear in a short time, and the effect is obvious.

DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION

EXAMPLE 1 preparation of granules

Prescription:

the preparation method comprises the following steps:

step A: respectively distilling herba Schizonepetae, radix Saposhnikoviae, Notopterygii rhizoma, radix Angelicae Pubescentis, radix Peucedani, rhizoma Ligustici Chuanxiong, and fructus Aurantii to obtain volatile oil, and respectively distilling the residue, rhizoma Ligustici Chuanxiong, and fructus Aurantii to obtain water solution;

step D: decocting radix bupleuri, platycodon grandiflorum, liquorice, the distilled schizonepeta obtained in the step A, divaricate saposhnikovia root, notopterygium root, radix angelicae pubescentis and radix peucedani dregs with water twice, each time for 1.5 hours, combining decoctions obtained in the two times, filtering and concentrating into thick paste for later use;

step E: and D, mixing the percolate obtained in the step C and the thick paste obtained in the step D, standing, filtering, concentrating into clear paste, adding a proper amount of cane sugar, uniformly mixing, preparing into granules, drying, adding the volatile oil obtained in the step A, and uniformly mixing to obtain the traditional Chinese medicine.

Example 2 preparation of granules

Prescription:

the preparation method is the same as example 1.

Example 3 preparation of granules

Prescription:

the preparation method is the same as example 1.

Example 4 oral liquid preparation

Prescription:

the preparation method comprises the following steps:

and B: b, preparing the distilled water solution of the ligusticum wallichii and the fructus aurantii obtained in the step A into a 10% ethanol solution for later use;

step E: and D, mixing the percolate obtained in the step C and the thick paste obtained in the step D, standing, filtering, concentrating into clear paste, adding a proper amount of sucrose, mixing uniformly, adding the volatile oil obtained in the step A, mixing uniformly, and adding water to 1000ml to obtain the traditional Chinese medicine composition.

EXAMPLE 5 syrup preparation

Prescription:

the preparation method comprises the following steps:

and B: b, preparing the distilled water solution of the ligusticum wallichii and the fructus aurantii obtained in the step A into a 40% ethanol solution for later use;

step E: and D, mixing the percolate obtained in the step C and the thick paste obtained in the step D, standing, filtering, concentrating into clear paste, adding a proper amount of cane sugar, mixing uniformly, adding 500ml of the volatile oil and the simple syrup obtained in the step A, mixing uniformly, standing, filtering, and adding water to 1000ml to obtain the traditional Chinese medicine.

EXAMPLE 6 tablet preparation

Prescription:

the preparation method comprises the following steps:

and B: b, preparing the distilled water solution of the ligusticum wallichii and the fructus aurantii obtained in the step A into a 15% ethanol solution for later use;

step E: and D, mixing the percolate obtained in the step C and the thick paste obtained in the step D, standing, filtering, concentrating into clear paste, adding a proper amount of cane sugar, uniformly mixing, granulating, drying, adding the volatile oil obtained in the step A, uniformly mixing, granulating, adding a proper amount of auxiliary materials, uniformly mixing, and tabletting to obtain the traditional Chinese medicine.

Example 7 Capsule preparation

Prescription:

and B: b, preparing the distilled water solution of the ligusticum wallichii and the fructus aurantii obtained in the step A into a 30% ethanol solution for later use;

step E: and D, mixing the percolate obtained in the step C and the thick paste obtained in the step D, standing, filtering, concentrating into clear paste, adding a proper amount of cane sugar, uniformly mixing, granulating, drying, adding the volatile oil obtained in the step A, uniformly mixing, granulating, drying, crushing and encapsulating to obtain the capsule.

EXAMPLE 8 pellet preparation

Prescription:

the preparation method comprises the following steps:

step E: and D, mixing the percolate obtained in the step C and the thick paste obtained in the step D, standing, filtering, concentrating into clear paste, adding a proper amount of cane sugar, uniformly mixing, preparing into granules, drying, adding the volatile oil obtained in the step A, uniformly mixing, drying, crushing, sieving, adding 40-60 g of refined honey and a proper amount of water, pelleting, and drying to obtain the traditional Chinese medicine.

Comparative example 1 preparation of granules

Prescription:

the preparation method comprises the following steps:

step A: respectively distilling herba Schizonepetae, radix Saposhnikoviae, Notopterygii rhizoma, radix Angelicae Pubescentis, and rhizoma Ligustici Chuanxiong to obtain volatile oil, and residue and aqueous solution;

and B: b, preparing the distilled water solution of the ligusticum wallichii obtained in the step A into a 25% ethanol solution for later use;

and C: mixing Poria and the distilled residue of rhizoma Ligustici Chuanxiong obtained in step A, percolating with the ethanol solution obtained in step B, and collecting percolate;

step D: decocting cassia twig, wrinkled gianthyssop herb, platycodon root, liquorice and the distilled schizonepeta, divaricate saposhnikovia root, notopterygium root and radix angelicae pubescentis dregs obtained in the step A with water twice, wherein each time lasts for 1.5 hours, combining decoction liquids of the two times, filtering and concentrating the filtrate into thick paste for later use;

Comparative example 2 preparation of granules

Prescription:

the preparation method comprises the following steps:

decocting the above materials in water for 2 times, mixing decoctions for 2 times, concentrating into fluid extract, adding appropriate amount of sucrose, and making into granule by conventional method.

Secondly, the traditional Chinese medicine composition has the treatment effect on diarrhea mice

In order to verify the efficacy of the traditional Chinese medicine composition for treating the air-conditioning syndrome, the inventor carries out related pharmacodynamic test research. It should be noted that the medicines selected in the pharmacodynamic tests below are the medicines obtained by the representative formula and the preparation method thereof; the inventor also conducts pharmacodynamic experiments on the medicines obtained by the other formulas and the preparation methods, and the experimental results show that the medicines obtained by the other formulas and the preparation methods have the same or similar effects, but the medicines are not exhaustive due to space limitations.

In addition, the pharmacodynamic experiments described below only take an animal model of gastrointestinal symptoms as an example to verify the efficacy of the present invention, and the inventor also made related pharmacodynamic experiments on other symptoms of the air-conditioning diseases mentioned in the present invention, and the experimental results show that the same or similar effects are achieved, and the experiments are not exhaustive.

The invention is further developed on the basis of the existing product of Jingfang granules, and the Jingfang granules have the effects of sweating, relieving exterior syndrome, dispelling wind and eliminating dampness. Can be used for treating wind-cold type common cold, headache, general pain, aversion to cold, no sweat, nasal obstruction, watery nasal discharge, cough, and white phlegm. Therefore, the efficacy of the traditional Chinese medicine composition in treating or relieving the symptoms of the air-conditioning disease cold is verified, and pharmacodynamic experimental study is not carried out.

The inventor explains that the following experimental studies are carried out on the basis of the safety of the drug proved by acute toxicity tests and long-term toxicity tests, and the administration dose in the experimental studies is within a safe dose range.

1 Material

1.1 animals:

kunming mouse, SPF level, 18-22 g, and the license number of experimental animal: SYXK (lu) 20180008, provided by lumnan pharmaceutical group ltd, was acclimatized for one week prior to the experiment.

1.2 drugs, reagents

1.2.1 medicaments

Granules obtained in examples 1 and 2 of the present invention

Granules obtained in comparative examples 1 and 2

Montmorillonite powder (Chinese medicine character of quan H20103630)

1.2.3 dosage

Example 1 granules: 2.925g/kg (high dose), 5.85g/kg (medium dose), 11.7g/kg (low dose)

Example 2 granules: 5.85g/kg

Comparative example 1 granules: 5.85g/kg

Comparative example 2 granules: 5.85g/kg

Montmorillonite powder: 1.17g/kg

2. Experimental methods

2.1 molding mode:

soaking folium sennae in water for 30min, boiling for about 10min, filtering, and concentrating the filtrate to obtain 1:1 water extractive solution. And (3) observing and recording the diarrhea condition of the mice according to the weight of the mice per 10g of the gavage by 0.2 mL/time, 2 times/d and 3d continuously, and calculating the loose stool rate, the loose stool grade and the diarrhea index. The presence or absence of diarrhea in mice is indicated by the appearance of unformed loose stools.

Diarrhea rate is the number of diarrhea animals/total number of animals in the group × 100%

Index of diarrhea (rate of loose stool x grade of loose stool)

The ratio of loose stool to the number of loose stools/total number of stools per animal (the degree of loose stool is based on the presence or absence of stains on filter paper)

The level of the dilute excrement is divided into 4 levels according to the range of the stains on the filter paper: the diameter of the first-level stain is less than 1 cm; the diameter of the second-level stain is 1.0-1.9 cm; the diameter of the third-stage stains is 2-3 cm; the stain diameter of the four stages is > 3 cm.

Generally, the diarrhea rate and the diarrhea index difference between the molding mouse and the normal mouse are obviously taken as the success of molding.

2.2 grouping

80 mice which are successfully molded are taken and randomly divided into a model group, a montmorillonite group, three dose groups (high, medium and low) of example 1, an example 2 group, a comparative example 1 group and a comparative example 2 group, wherein each group comprises 10 mice. The mice of each administration group were gavaged with the corresponding drugs, and the model group was gavaged with an equal amount of physiological saline. And observing and recording the diarrhea condition of each group of mice within 6h, and calculating the loose stool rate, the loose stool grade and the diarrhea index.

2.3 statistical treatment

Statistical analysis is carried out on the obtained data by adopting SPSS22.0 software, and the data is measured

The results of the two groups are shown in the specification, and the two groups are analyzed by a T test mode. With P<A difference of 0.05 is statistically significant.

3. Results and conclusions

Compared with the model group, the mice in each administration group have obviously reduced loose stool rate, loose stool grade and diarrhea index (P <0.05, P < 0.01); compared with the group of example 2, the mice of the comparative examples 1 and 2 have obviously higher loose stool rate, loose stool grade and diarrhea index (P <0.05 and P < 0.01). The traditional Chinese medicine composition has a better treatment effect on diarrhea mice, and the effect is obviously better than that of the comparative example.

TABLE 1 comparison of diarrhea index results for groups of mice: (

n＝10)

Note: in contrast to the model set,^△P＜0.05，^#P＜0.01；

compared with the montmorillonite bulk group,^@P＜0.05，^*P＜0.01；

in contrast to the group of example 2,^&P＜0.05，^￥P＜0.01。

second, drug administration experiment

1 general data and methods

1.1 general data

According to the voluntary principle, 40 air-conditioning cold-air syndrome patients diagnosed by the company between 8 and 1 months in 2019 and 8 and 31 months in 2019 are collected. Male 10, female 30, minimal 20, maximal 48, and average age (32.12 ± 3.26). Diagnostic criteria: (1) before the disease occurs, the work or life history of the air conditioner environment is available, and the time is more than or equal to 6 h; (2) the clinical manifestations are aversion to cold, fever, headache, general aching pain, hypodynamia, nausea, vomiting, epigastric fullness, thirst, profuse sweat or no sweat.

1.2 methods of treatment

Patients are treated by Jingfang granules (the manufacturer: Shandong New era pharmaceutical industry Co., Ltd.; approved article: Chinese medicine standard Z37020357), and the main formula comprises herba Schizonepetae, radix Saposhnikoviae, Notopterygii rhizoma, radix Angelicae Pubescentis, bupleuri radix, radix Peucedani, rhizoma Ligustici Chuanxiong, fructus Aurantii, Poria, radix Platycodi, and Glycyrrhrizae radix, and is taken with boiled water 1 time, 1 bag for 1 day and 3 times for 7 days.

The patient recorded the symptoms daily during the dosing period.

1.3 Observation index

The treatment effect is judged by the 'standard of curative effect for diagnosing the disease of traditional Chinese medicine'.

And (4) invalidation: the symptoms of the patient are not improved or even aggravated after the patient is treated for 6 days;

improvement: within 6 days of treatment, 1 or 2 of 3 main symptoms disappear, and the other 1 or 2 symptoms are obviously weakened;

and (3) curing: all symptoms disappeared without recurrence and the mental status returned to the previous level within 6 days of patient treatment.

The effective rate of treatment (improvement + cure)/the total number of people.

2 results

2.1 clinical efficacy

The treatment cure number is 18, the improvement number is 20, the effective number is 38, the treatment effective rate is 95.00%, and the effect is obvious.

Table 2 effective rate results of the treatment (n ═ 40)

2.2 improvement of the chief complaints

The main symptoms of the patients are obviously improved after the treatment, and other secondary symptoms are also obviously improved.

Table 3 patient chief complaint improvement results (n ═ 40)

Clinical research results show that symptoms of patients treated by the Jingfang granules disappear in a short time, so that the Jingfang granules have good effect on treating patients with air-conditioning cold air syndrome and can be popularized.

Claims

1. A Chinese medicinal composition is prepared from Notopterygii rhizoma, radix Angelicae Pubescentis, Poria, radix Saposhnikoviae, herba Schizonepetae, rhizoma Ligustici Chuanxiong, radix Platycodi, bupleuri radix, radix Peucedani, fructus Aurantii, and Glycyrrhrizae radix.

2. The use of claim 1, wherein the Chinese medicinal composition is prepared from the following raw materials:

3. the use of claim 2, wherein the Chinese medicinal composition is prepared from the following raw materials:

4. the use of claim 3, wherein the Chinese medicinal composition is prepared from the following raw materials:

5. a Chinese medicinal preparation, which is characterized by comprising the Chinese medicinal composition as claimed in any one of claims 1 to 4 and pharmaceutically acceptable auxiliary materials.

6. The traditional Chinese medicine preparation of claim 5, wherein the traditional Chinese medicine preparation is a clinically acceptable oral preparation; preferably, the clinically acceptable oral preparation is one or more of pills, capsules, tablets, granules or liquid oral preparations.

7. The traditional Chinese medicine preparation of claim 6, wherein the granules are Jingfang granules.

8. Use of the Jingfang granules according to claim 7 for the preparation of a medicament for the treatment and/or prevention of the air conditioning syndrome.

9. A method for preparing the Chinese medicinal composition of any one of claims 1 to 7, wherein the method comprises the following steps:

10. The method of claim 9, wherein the method of preparation essentially comprises the steps of: