CN102362909A - Method for preparing schizonepeta and divaricate saposhnikovia root oral liquid for removing toxin - Google Patents
Method for preparing schizonepeta and divaricate saposhnikovia root oral liquid for removing toxin Download PDFInfo
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- CN102362909A CN102362909A CN2011101788070A CN201110178807A CN102362909A CN 102362909 A CN102362909 A CN 102362909A CN 2011101788070 A CN2011101788070 A CN 2011101788070A CN 201110178807 A CN201110178807 A CN 201110178807A CN 102362909 A CN102362909 A CN 102362909A
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Abstract
The invention relates to a method for preparing schizonepeta and divaricate saposhnikovia root oral liquid for removing toxin. The method comprises the following steps of: (1) distilling schizonepeta, divaricate saposhnikovia root, incised notopterygium rhizome, heracleum, bitter orange, ligusticum wallichii, whiteflower hogfennel root and mint to extract volatile oil, and collecting an aqueous solution obtained after distillation in a container; (2) treating the decoction dregs of ligusticum wallichii and bitter orange, and tuckahoe by a percolation method to obtain colature, namely adding 25 weight percent of ethanol into the aqueous solution obtained after distillation in the step (1) to obtain a mixture serving as a solvent, performing percolation, collecting colature, and recovering ethanol under reduced pressure; and (3) adding water into decoction dregs of schizonepeta, divaricate saposhnikovia root, incised notopterygium rhizome, heracleum, and whiteflower hogfennel root, and bupleurum chinense, platycodon grandiflorus, and liquorice, and decocting for three times, filtering, mixing filtrate, concentrating until the solution is 1,300ml, mixing the solution and colature which is obtained in the step (2), standing, filtering, concentrating until the solution is 1,000ml, adding 3 parts of sodium benzoate, and the volatile oil which is obtained in the step (1), uniformly stirring, and adding water to ensure the solution is 1,000ml to obtain the oral liquid. Ethanol which is produced when the schizonepeta and divaricate saposhnikovia root oral liquid for removing toxin is produced can be recovered by equipment special for recovering ethanol; the produced decoction dregs can be used for manure collection or agriculture supporting; and waste gases are avoided.
Description
Technical field
The invention belongs to the special-purpose medicine of poultry field, especially a kind of method for preparing of Jingfang toxicity-removing oral liquid.
Background technology
Along with the development of society and the change of human diseases spectrum; The pattern of medical treatment changes prevention, health care, treatment, rehabilitation into by simple disease treatment and combines; When various traditional medicines played a role, the cry of human back to nature, recurrence green was increasingly high.Chinese medicine is as the part of traditional medicine culture, and peculiar theoretical system, significant clinical efficacy are familiar with by people.China second largest in the world plant amedica of conduct host country of the resources, Chinese medicine has advantageous advantage, exports 130 countries and regions all over the world at present, and Chinese medicine goes to the world, and promotes the well-being of mankind.21 century will be that Chinese traditional medicine is able to revive and the period of developing comprehensively.
Chinese veterinarian's medicine has long history and rich experiences in China; Along with the development of animal husbandry scale, intensification, and the pathogen Drug resistance that the long-term abuse of antibiotic causes strengthens day by day, and the residual social danger of medicine is outstanding day by day; At back to nature; Develop the market demand of green veterinary drug, Chinese medicine solves Drug resistance and the residual important aspect of medicine as substituting antibiotic, more and more receives people's attention.Unique effect and clinical efficacy are especially arranged at aspects such as immunomodulating, antiviral, inhibition coli-infections.
At present respiratory tract disease is one of main harm that threatens poultry farming, as outstanding influenza (below be called influenza) be a kind of sickness rate of causing by influenza virus high, popular extensively, propagate rapidly, eqpidemic disease that mortality rate is high.Sexuality was emitted the category with pathogenic wind-warm when influenza belonged to motherland's medical science, polyphyly adverse weather, the evil poison of impression, epidemic miasma and fall ill.China people are in the process of long-term and disease struggle; Accumulated most valuable theory and practice knowledge aspect the herbal control influenza utilizing; It is reported China be used to prevent among the people single proved recipe of influenza just have 100 surplus kind; Wherein more by the kind of Herba Schizonepetae, prescription such as windproof, curative effect is more satisfactory." Antiphlogistic Powder of Schizonepetae and Ledebouriellae " that China's veterinary drug allusion quotation version in 2000 is picked, its prescription belongs to classical control that is used for influenza, but onset is slower; And because the poultry digestive tract is shorter; Decomposition and absorption to medicine is incomplete, and the utilization rate of medical material is lower, therefore aspect the selection dosage form; We consider to be easy to absorb, rapid-action oral liquid formulations, the characteristic and the advantage of performance Chinese medicine.
China is Chinese medicine big producing country, but because Chinese medicine ingredients is complicated, pharmacological action is indeterminate; Especially the quality standard imperfection detects and analyzes difficulty, and factors such as quality of medicinal material instability cause Chinese medicine quality unstable; Uncertain therapeutic efficacy is cut, and also seriously limits China's Chinese medicine outlet, makes the share less than 5% of China in international Chinese medicine market; The status of Chinese medicine industry and Chinese medicine big country is extremely unbecoming, family surplus the present Chinese medicine preparation for animals manufacturer whole nation has reached 1000, and kind is thousands of; As a whole, Chinese medicine preparation production for animals still is in the junior stage, and scientific and technological content is not high; Dosage form is coarse; Difficult quality control, modern Chinese medicine for animals should be: efficient, high-quality, quality controllable, convenient drug administration, animal-use drug of new generation with modern formulation and don't disalignment medicine characteristic, and its production should be scale, standardization, modernization, internationalization.
Summary of the invention
The objective of the invention is to overcome the weak point of prior art, propose that a kind of pure Chinese medicinal preparation, effect are rapid, rapid-action, the method for preparing of Jingfang toxicity-removing oral liquid with better therapeutic effect.
The present invention realizes that the technical scheme of purpose is:
A kind of method for preparing of Jingfang toxicity-removing oral liquid is characterized in that: raw material and parts by weight are following:
The windproof 80-100 Rhizoma Et Radix Notopterygii of Herba Schizonepetae 130-140 70-80 Radix Angelicae Pubescentis 70-80
Radix Bupleuri 80-100 Radix Peucedani 70-80 Fructus Aurantii 80-100 Poria 130-140
Radix Platycodonis 80-100 Rhizoma Chuanxiong 70-80 Radix Glycyrrhizae 40-50 Herba Menthae 40-50
Step is following:
(1) Herba Schizonepetae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Fructus Aurantii, Rhizoma Chuanxiong, Radix Peucedani and Herba Menthae distillating extracting oil respectively, the aqueous solution after distillation device is in addition collected;
(2) medicinal residues of Rhizoma Chuanxiong, Fructus Aurantii and Poria are with the method for filtering, and the liquid of filtering is: the aqueous solution after step (1) distillation adds parts by weight 25% ethanol and makes solvent, and the Hang percolate of Jin is collected the liquid of filtering, decompression recycling ethanol.
(3) medicinal residues of Herba Schizonepetae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Peucedani and Radix Bupleuri, Radix Platycodonis, Radix Glycyrrhizae decocte with water are three times, filter merging filtrate; Be concentrated into about 1300ml,, leave standstill with the liquid merging of filtering of step (2); Filter, be concentrated into about 1000ml, add the volatile oil that 3 parts of sodium benzoate and step (1) obtain; Stir, add water and make into 1000ml, promptly get.
And said raw material and parts by weight are following:
Herba Schizonepetae 135 windproof 90 Rhizoma Et Radix Notopterygiis, 75 Radix Angelicae Pubescentiss 75
Radix Bupleuri 90 Radix Peucedanis 75 Fructus Aurantiis 90 Poria 135
Radix Platycodonis 90 Rhizoma Chuanxiongs 75 Radix Glycyrrhizaes 45 Herba Menthaes 45.
Advantage of the present invention and beneficial effect are:
1, the present invention's Jingfang toxicity-removing oral liquid of inventing preparation has relieving the exterior syndrome with drugs of pungent in flavor and warm in nature; The function of dispelling wind damp eliminating; Be mainly used in respiratory tract, digestive tract, nervous system abnormality that influenza causes; The fever that causes like respiratory system,, sneeze, shed tears, mucus nose juice, incidence edema, the swelling of cockscomb wattle are livid purple, dyspnea etc.; The diarrhoea that digestive system causes, dysentery etc.; That nervous system causes is spiritual depressed, loss of appetite, hang one's head and the eqpidemic disease treatment of lethargy.
2, the ethanol that when the Jingfang toxicity-removing oral liquid is produced, produces of the present invention has special-purpose ethanol reclaimer; The medicinal residues that produce are used for collected manure or support agriculture; No waste gas produces.
The specific embodiment
Through specific embodiment the present invention is made further detailed description below, following examples are descriptive, are not determinate, can not limit protection scope of the present invention with this.
A kind of method for preparing of Jingfang toxicity-removing oral liquid, raw material is following:
The windproof 90g Rhizoma Et Radix Notopterygii of Herba Schizonepetae 135g 75g Radix Angelicae Pubescentis 75g
Radix Bupleuri 90g Radix Peucedani 75g Fructus Aurantii 90g Poria 135g
Radix Platycodonis 90g Rhizoma Chuanxiong 75g Radix Glycyrrhizae 45g Herba Menthae 45g
Step is following:
(1) Herba Schizonepetae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Fructus Aurantii, Rhizoma Chuanxiong, Radix Peucedani and Herba Menthae water distillating extracting oil respectively, the aqueous solution after distillation device is in addition collected;
(2) medicinal residues of Rhizoma Chuanxiong, Fructus Aurantii and Poria are according to the method for filtering (an appendix I of Chinese Pharmacopoeia version in 2000 O) under fluid extract and the extractum item; The liquid of filtering is: add parts by weight 25% ethanol with the aqueous solution after the distillation and make the Hang percolate of solvent Jin, collect the liquid of filtering, decompression recycling ethanol.
(3) medicinal residues of Herba Schizonepetae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Peucedani and Radix Bupleuri, Radix Platycodonis, Radix Glycyrrhizae decocte with water are three times, filter merging filtrate; Be concentrated into about 1300ml,, leave standstill with the liquid merging of filtering of step (2); Filter, be concentrated into about 1000ml, add the volatile oil that sodium benzoate 3g and step (1) obtain; Stir, add water and make into 1000ml, promptly get.
Character: these article are brown solution.
Function with cure mainly: relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, dispelling wind damp eliminating.Be mainly used in respiratory tract, digestive tract, nervous system abnormality that influenza causes, the fever that causes like respiratory system,, sneeze, shed tears, mucus nose juice, incidence edema, the swelling of cockscomb wattle are livid purple, dyspnea etc.; The diarrhoea that digestive system causes, dysentery etc.; That nervous system causes is spiritual depressed, loss of appetite, hang one's head and the eqpidemic disease treatment of lethargy.
Usage and consumption: fowl mixes the every 1L water of drink and adds these article 0.5ml logotype 3-5 days
The test of Jingfang toxicity-removing oral liquid clinical treatment
1 test material and method
1.1 test material
1.1.1 trial drug Jingfang toxicity-removing oral liquid (having another name called speed sense spirit), specification is the 100ml/ bottle.Character is the supernatant liquid of brownish black, and lot number is 061201,2 years effect duration.Recommendering folder medicine treatment usage and consumption are that birds drinking-water is used with, and every 1L drinking-water adds these article 0.5ml, drinks continuously 3～5 days.
1.1.2 60 of laboratory animal 10 Japanese instar chicklings, the kind assorted generation that is AA-Luo Man meat is prone to kind of chicken house by Hua Zhong Agriculture University China and buys, chickling is in a good state of health, and does not do any immunity.
1.1.3 the feedstuff broiler chickens mixed feed is by hoping that feedstuff company buys.
1.1.4 vaccine newcastle disease (Lasota system) infectious bronchitis (H120 strain) bigeminal live vaccine, Jilin Province's biological factory is produced, and lot number is 20061105,2 years effect duration.Infectious bursal disease trivalent live vaccine, the Chinese Academy of Agricultural Sciences's Harbin veterinary institute is produced, and lot number is 061212,2 years effect duration.
1.1.5 viral bird flu virus H9 hypotype ferrum, animal medicine institute of Hua Zhong Agriculture University Preventive Veterinary Medicine laboratory is preserved strain, is the low pathogenicity Strain.The side venom EID50 that falls ill is 10-7.8/0.2ml.
1.2 test method
1.2.1 the low nose eye dripping inoculation of immunization trial chickling 10 ages in days newcastle (Lasota) infectious bronchitis (H
120) the bigeminal live vaccine immunity, 15 ages in days are with the immunity of infectious bursal disease trivalent live vaccine collunarium eye dripping.
1.2.2 measure chicken crowd's newcastle (ND), infectious bronchitis (IB), infectious bursal disease (IBD) and bird flu (AI) H9 hypotype antibody horizontal during TPPA 20 ages in days.Side gets DN, IB, HI antibody titer and is respectively 2
7.8, 2
6.2IBDAGP antibody is 2
2-2
3, no AIH9 hypotype HI antibody.
1.2.3 test divides into groups 20 age in days test chickens are divided into 2 groups, 30 every group, the 1st group is the treatment group (2g/ days) of Antiphlogistic Powder of Schizonepetae and Ledebouriellae; The 2nd group is Jingfang toxicity-removing oral liquid treatment group (recommended amounts is 0.5mL/L).
1.2.4 infection experiment is to every oral and intramuscular injection avian influenza venom (H of 1,2 group of test chicken
9The hypotype strain) each 0.1ml (0.2mL/ only).Infect the back and note observing chicken crowd variation, when manifest symptom occurring, divide into groups by experiment, with in Antiphlogistic Powder of Schizonepetae and Ledebouriellae spice and the Jingfang toxicity-removing oral liquid drinking-water 1～2 group of test chicken being treated respectively, the treatment phase was made as 5 days according to the medicament description.Observe the variations such as spirit, breathing, diet, feces of 1～2 group of chickling simultaneously, and the sick chicken of death is cutd open inspection observe pathological change, carry out record simultaneously.Test grouping, infection, referral are seen table 1.
Table 1 infection experiment (low pathogenicity bird flu case is duplicated) and treatment grouping situation
1.2.5 curative effect is sorted in sick chicken transference cure during the treatment, it is normal for curing that diet, breathing, feces and the mental status are recovered; Sick chicken symptom obviously alleviates, and diet, breathing, feces and the mental status take an evident turn for the better and be produce effects; Sick chicken symptom alleviates to some extent, and diet, breathing, feces and the mental status are good to some extent to be transferred to effectively; Sick chicken symptom does not alleviate or continues and increases the weight of during treating, and diet, breathing, feces and the mental status are not got better and changeed or dead midway for invalid.
2 result of the tests
2.1 incidence
At oral and intramuscular injection avian influenza venom (H
9The hypotype strain) metainfective the 2nd day (about 45h), 1～4 group of test chicken had slight infection symptoms has approximately that lassitude, loss of appetite appear in 40% chicken, drinking-water increases and symptom such as laxativeness; The 3rd day, have approximately 95% chicken occur lassitude, loss of appetite or useless exhausted, drinking-water increases, diarrhoea, and the different respiratory symptom of the degree that shows etc.
2.2 treatment situation
From infecting back beginning in the 3rd day; Give 1～2 group of chicken interpolation Drug therapy of drinking water, the 2～3h that cuts off the water earlier before the treatment press the dose of table 1 setting then; With 1～2 group of test chicken being treated continuous 5 days respectively in Antiphlogistic Powder of Schizonepetae and Ledebouriellae spice and the Jingfang toxicity-removing oral liquid drinking-water.Viewing test chicken diet, breathing, feces, the mental status and death condition etc., and perform record.Carry out statistical analysis by the curative effect classification after the off-test.The result sees table 2.
Table 2 Jingfang toxicity-removing oral liquid (speed sense spirit) duplicates the therapeutic effect of case to the low pathogenicity bird flu
3 brief summaries and discussion
3.1 infection experiment
Give 1～2 group of test chicken, after infecting with LPAIV liquid (strain of H9 hypotype), about 45h infected chicken had slight infection symptoms, symptoms such as sick chicken performance lassitude, loss of appetite, drinking-water increase and laxativeness.Morbidity chicken quantity increased in the 3rd day, sx, and sick chicken is except that performance lassitude, drinking-water increase; General loss of appetite or useless exhausted, diarrhoea increase the weight of; And showing more serious respiratory symptom etc., sickness rate explains that more than 96.67% it is successful that case is duplicated.
3.2 therapeutic test
From infecting back beginning in the 3rd day; To 1～2 group of chicken with treating respectively in Antiphlogistic Powder of Schizonepetae and Ledebouriellae spice and the Jingfang toxicity-removing oral liquid drinking-water; In 5 days of treatment; Explain that the Jingfang toxicity-removing oral liquid is rapid-action than Antiphlogistic Powder of Schizonepetae and Ledebouriellae, the low pathogenicity bird flu is had the good curing effect, 1～2 group total effective rate reaches 34.48% and 93.33% respectively.The therapeutic effect of Jingfang toxicity-removing oral liquid all obviously is superior to Antiphlogistic Powder of Schizonepetae and Ledebouriellae.
Test period: on April 15,2007 5 days to 2007 March in
Test place: animal medicine institute of Hua Zhong Agriculture University pharmacological evaluation chamber
Raw data preservation place: animal medicine institute of Hua Zhong Agriculture University pharmacological evaluation chamber
The acute toxicity test of Jingfang toxicity-removing oral liquid
1 test material and method
1.1 test material
1.1.1 trial drug Jingfang toxicity-removing oral liquid (having another name called speed sense spirit), specification is the 100ml/ bottle.Character is the supernatant liquid of brownish black, and lot number is 061201,2 years effect duration.
1.1.2 50 of laboratory animal 10 Japanese instar chicklings, the kind assorted generation that is AA-Luo Man meat is prone to kind of chicken house by Hua Zhong Agriculture University China and buys, chickling is in a good state of health, and does not do any immunity.
1.1.3 the feedstuff broiler chickens mixed feed hopes that feedstuff company buys.
1.1.4 vaccine newcastle disease (Lasota system) infectious bronchitis (H
120Strain) bigeminal live vaccine, Jilin Province's biological factory is produced, and lot number is 20061105, valid until 2008/11/04.Infectious bursal disease trivalent live vaccine, the Chinese Academy of Agricultural Sciences's Harbin veterinary institute is produced, and lot number is 061212,2 years effect duration.
2 methods
The immunity of test chickling 10 age in days collunarium eye dripping inoculation newcastle (Lasota) infectious bronchitis (H120) bigeminal live vaccine, 15 ages in days are with the immunity of infectious bursal disease trivalent live vaccine collunarium eye dripping.
2.1 test is divided into groups and medication
20 age in days test chickens are divided into 5 groups, and 10 every group, the 1st group is RD group (for 0.5mL/L); The 2nd group of 1.0mL/L; The 3rd group is 1.5 multiple dose groups (1.5ml); The 4th group is 2 multiple dose groups (2ml); The 5th group is blank article (not infecting not administration).More than each group be mixed in the drinking-water 5 days according to speed sense medicine liquid various dose.
Observe the variations such as spirit, breathing, diet, feces of 1～5 group of chickling simultaneously, and the sick chicken of death is cutd open inspection observe pathological change, carry out record simultaneously, observed continuously 15 days.
Table 1 test grouping situation and medication
3 result of the tests
3.1 morbidity death condition
During treating, test group and matched group chicken diet, breathing, feces and mental status no abnormality seen all do not have death and see table 1.
Table 1 morbidity and death condition:
3.2 pathological change is observed
Respectively organize chicken and carry out pathologic finding above, test group and matched group are not all seen significant change.
4 conclusions
This result of the test shows that Jingfang toxicity-removing oral liquid (speed sense spirit) is safe recommending therapeutic dose to double (4 times).
Test period: on February 4,2007 5 days to 2007 January in
Test place: animal medicine institute of Hua Zhong Agriculture University pharmacological evaluation chamber
Raw data preservation place: animal medicine institute of Hua Zhong Agriculture University pharmacological evaluation chamber
Claims (2)
1. the method for preparing of a Jingfang toxicity-removing oral liquid, it is characterized in that: raw material and parts by weight are following:
The windproof 80-100 Rhizoma Et Radix Notopterygii of Herba Schizonepetae 130-140 70-80 Radix Angelicae Pubescentis 70-80
Radix Bupleuri 80-100 Radix Peucedani 70-80 Fructus Aurantii 80-100 Poria 130-140
Radix Platycodonis 80-100 Rhizoma Chuanxiong 70-80 Radix Glycyrrhizae 40-50 Herba Menthae 40-50
Step is following:
(1) Herba Schizonepetae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Fructus Aurantii, Rhizoma Chuanxiong, Radix Peucedani and Herba Menthae distillating extracting oil respectively, the aqueous solution after distillation device is in addition collected;
(2) medicinal residues of Rhizoma Chuanxiong, Fructus Aurantii and Poria are with the method for filtering, and the liquid of filtering is: the aqueous solution after step (1) distillation adds parts by weight 25% ethanol and makes solvent, and the Hang percolate of Jin is collected the liquid of filtering, decompression recycling ethanol.
(3) medicinal residues of Herba Schizonepetae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Peucedani and Radix Bupleuri, Radix Platycodonis, Radix Glycyrrhizae decocte with water are three times, filter merging filtrate; Be concentrated into about 1300ml,, leave standstill with the liquid merging of filtering of step (2); Filter, be concentrated into about 1000ml, add the volatile oil that 3 parts of sodium benzoate and step (1) obtain; Stir, add water and make into 1000ml, promptly get.
2. the method for preparing of Jingfang toxicity-removing oral liquid according to claim 1 is characterized in that: said raw material and parts by weight are following:
Herba Schizonepetae 135 windproof 90 Rhizoma Et Radix Notopterygiis, 75 Radix Angelicae Pubescentiss 75
Radix Bupleuri 90 Radix Peucedanis 75 Fructus Aurantiis 90 Poria 135
Radix Platycodonis 90 Rhizoma Chuanxiongs 75 Radix Glycyrrhizaes 45 Herba Menthaes 45.
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| WO2021164037A1 (en) * | 2020-02-22 | 2021-08-26 | 肖鸣春 | Medication for treating influenza or infectious disease |
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| CN114073731A (en) * | 2020-08-14 | 2022-02-22 | 鲁南制药集团股份有限公司 | A Chinese medicinal composition for treating abdominal pain and diarrhea |
| CN114146121A (en) * | 2020-09-08 | 2022-03-08 | 鲁南制药集团股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating dyspepsia |
| CN114146122A (en) * | 2020-09-08 | 2022-03-08 | 鲁南制药集团股份有限公司 | Traditional Chinese medicine composition for treating anorexia |
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Application publication date: 20120229 |