CN1958008A - Animal use compound medicament with effects of removing toxic heat, and preparation method - Google Patents
Animal use compound medicament with effects of removing toxic heat, and preparation method Download PDFInfo
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- CN1958008A CN1958008A CN 200510015792 CN200510015792A CN1958008A CN 1958008 A CN1958008 A CN 1958008A CN 200510015792 CN200510015792 CN 200510015792 CN 200510015792 A CN200510015792 A CN 200510015792A CN 1958008 A CN1958008 A CN 1958008A
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- herba houttuyniae
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Abstract
A compound veterinary medicine in the form of powder for clearing heat and removing toxin is prepared from houttuynia, scutellaria root, isatis root, forsythia fruit and honeysuckle flower. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to and be particularly related to the smart powder of compound houttuynin and the preparation technology's method thereof that a kind of poultry are used in poultry medicine and the field of veterinary.
Background technology
Chinese medicine and pharmacy is one of important component part in the cultural treasure-house of China's medicine, and Chinese herbal medicine then is the culture rarity of China.Aspect animal medicine, traditional Chinese veterinary medicine is also playing crucial effect aspect the Clinics and Practices of livestock and poultry.
The compound houttuynin prescription has the effect of heat-clearing and toxic substances removing, is used for the treatment of acute inflammation of the throat, acute tonsillitis that affection due to external wind and heat causes, shows as red swelling of the pharynx, pharyngalgia; Disease such as acute laryngitis, acute tonsillitis.2005 editions Pharmacopoeia of the People's Republic of China record FUFANG YUXINGCAO PIAN have the effect of heat-clearing and toxic substances removing, are used for the treatment of acute inflammation of the throat, acute tonsillitis that affection due to external wind and heat causes, show as red swelling of the pharynx, pharyngalgia; Disease such as acute laryngitis, acute tonsillitis; Its preparation technology is Herba Houttuyniae, Radix Scutellariae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae five kinds of Chinese medicine, gets 1/3rd of used Herba Houttuyniae dosage, is broken into fine powder with Fructus Forsythiae, Flos Lonicerae powder, remaining Herba Houttuyniae and Radix Scutellariae, Radix Isatidis decoct with water secondary, and each 2 hours, collecting decoction, filter, filtrate is condensed into thick paste, adds above-mentioned fine powder, mixing, drying is ground into fine powder, make granule, drying, sugar coating, promptly.2000 editions " People's Republic of China's veterinary drug allusion quotation " record Herba Houttuyniae injectio has the effect of heat-clearing and toxic substances removing, detumescence and apocenosis, inducing diuresis for treating stranguria syndrome.
The using method of herbal medicine mainly is to carry out mixed feeding or mix drink after directly medicine being pulverized at present, though using method is simple, does not often reach better curative effect.Because the special physiological structure of poultry is directly treated medical material in the mode of crude drug, usually can not get good absorption, major part can be excreted, and the effect of treatment is very little, has wasted a large amount of medical materials simultaneously; Use Herba Houttuyniae injectio for animals to be used for the treatment of livestock and poultry, cost is higher relatively and administering mode is inconvenient.Do not retrieve at present the application of the smart powder of compound houttuynin on poultry as yet.
Summary of the invention
Technical problem to be solved by this invention is the smart powder of the compound houttuynin with effects for removing toxic heat that provides a kind of poultry to use and preparation technology's method thereof.Be used for the treatment of acute inflammation of the throat, acute tonsillitis that poultry cause because of affection due to external wind and heat, show as red swelling of the pharynx, pharyngalgia; A kind of pure Chinese medicinal preparation of disease such as acute laryngitis, acute tonsillitis.
Technical scheme of the present invention is:
The smart powder of the compound houttuynin that a kind of poultry are used, it is characterized in that: the raw material by following part by weight is made:
Herba Houttuyniae 483-583g, Radix Scutellariae 124-150g, Radix Isatidis 124-150g, Fructus Forsythiae 48g-58g, Flos Lonicerae 48g-58g
Adopt following method to make:
Described five kinds of Chinese medicine, get 1/3rd of used Herba Houttuyniae dosage, become fine powder with Fructus Forsythiae, Flos Lonicerae after pulverizing, remaining Herba Houttuyniae and Radix Scutellariae, Radix Isatidis decoct with water twice, each 2 hours, be merged into decocting liquid, filter, filtrate is condensed into thick paste, adds above-mentioned fine powder, mixing, crushed after being dried promptly get the smart powder of compound houttuynin.
The smart powder of the compound houttuynin that these poultry are used, it is characterized in that: the raw material by following weight preferred proportion is made: Herba Houttuyniae 483g, Radix Scutellariae 124g, Radix Isatidis 124g, Fructus Forsythiae 48g, Flos Lonicerae 48g.
Described five kinds of Chinese medicine, get 1/3rd of used Herba Houttuyniae dosage, become fine powder with Fructus Forsythiae, Flos Lonicerae after pulverizing, remaining Herba Houttuyniae and Radix Scutellariae, Radix Isatidis decoct with water twice, each 2 hours, be merged into decocting liquid, filter, filtrate is condensed into thick paste, adds above-mentioned fine powder, mixing, crushed after being dried promptly get the smart powder of compound houttuynin.
Using method of the present invention is: be used for the treatment of acute inflammation of the throat, acute tonsillitis that poultry cause because of affection due to external wind and heat, show as red swelling of the pharynx, pharyngalgia; Disease such as acute laryngitis, acute tonsillitis.Usage is spice or mixes drink, horse, cattle: 15-20g/ head/sky, and sheep, pig: 5-7g/ head/sky, spice, 3-5 days is a course of treatment; Poultry: 0.05-0.15g//day, mix drink, 3-5 days is a course of treatment.
Effect of the present invention is:
The reference man uses officinal FUFANG YUXINGCAO PIAN, the present invention improves at the special physiological structure of poultry on the basis of existing dosage form, and for example big domestic animal mostly is many stomaches plant-eating animal, directly the former prescription medicinal powder of mixed feeding compound houttuynin, often be difficult for absorbing, cause waste.The present invention has effectively improved the original preparation cost of compound houttuynin height, has been difficult for the shortcoming of absorption, be made into the smart powder of compound houttuynin, active component in the medicine has overcome the problem of the direct oral absorption rate variance of Chinese drugs powder, has reduced aquaculture cost on the whole, has effectively improved cure rate.The present invention is used for the treatment of diseases such as heating due to the flu that domestic animal, poultry cause because of affection due to external wind and heat, cough, pharyngalgia, can play the effect of dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing.This medicine is a pure Chinese medicinal preparation simultaneously, without any toxic and side effects.
For verifying effect of the present invention, carry out following test:
Trial drug: trial drug is the smart powder of compound houttuynin, control drug be the compound houttuynin powder (according to the weight proportion of various medical materials in the described compound houttuynin prescription, pulverize after preparing, sieve, mixing is the compound houttuynin powder.Crude drug is available from the pharmacy, Tianjin).
Experimental animal: 390 of 1 aa broiler chicken, provide by the chicken farm, Tianjin, according to normal immune programme for children vaccination, the complete feed of feeding is freely drunk water.
Strain, strain: fowl deteriorated blood Mycoplasma, avian infectious bronchitis virus M
41Strain.
Test method
Counteracting toxic substances dosimetry: get 40 of test chickens, divide 4 groups at random, per nasal, eye splash into avian infectious bronchitis virus and fowl deteriorated blood Mycoplasma equivalent mixed liquor 0.1,0.2,0.3,0.4ml respectively, observe the chicken incidence behind the counteracting toxic substances, determine that 0.2ml (containing 1.0 hundred million of viable bacterias) is for being fit to counteracting toxic substances dosage.
The test grouping: 350 of 10 age in days chickens are divided into 7 groups, 50 every group at random.The 1st group is the smart powder high dose group of compound houttuynin (0.15g//day is mixed drink); The 2nd group is dosage group in the smart powder of compound houttuynin (0.1//day is mixed drink); The 3rd group is the smart powder low dose group of compound houttuynin (0.05g//day is mixed drink); Every chicken splashes into infected material by the counteracting toxic substances dosage per nasal of determining, eye.Test chicken is 24h behind counteracting toxic substances, by the smart powder of high, medium and low dosage drink-service compound houttuynin, connects and drinks 5 days respectively.The 4th group is the medicine matched group, and 24h presses 2g//day dosage drink-service behind the counteracting toxic substances, and method is the same.5 groups of positive matched groups, not medication of counteracting toxic substances, the infection method is the same.The 6th group is the blank group, counteracting toxic substances not, not medication.The 7th group is safe matched group, and 10 times of administrations that healthy chicken is pressed the smart powder recommended dose of compound houttuynin mix drink, logotype 5 days (table 1).
The grouping of table 1 test chicken
| Group | Test chicken number (only) | For the reagent thing | Drug level (g//day) | The medication natural law (my god) |
| 1 | 50 | The smart powder high dose group of compound houttuynin | 0.15 mix drink | 5 |
| 2 | 50 | Dosage group in the smart powder of compound houttuynin | 0.1 mix drink | 5 |
| 3 | 50 | The smart powder low dose group of compound houttuynin | 0.05 mix drink | 5 |
| 4 | 50 | The medicine matched group | 2 mixed feedings | 5 |
| 5 | 50 | Infect matched group | 0 | |
| 6 | 50 | Normal healthy controls (not infecting) group | 0 | |
| 7 | 50 | The smart powder safe dose of compound houttuynin group | 1.5 mix drink | 5 |
The efficacy assessment standard: duration of test, every day, observed and recorded was added up effective percentage, mortality rate and the relative weight gain rate after the course of treatment.
Chicken number * 100% before effective percentage (%)=treatment back survival chicken number/dispensing
Dead chicken number in mortality rate (%)=treatment/dispensing back chicken number * 100%
Average every chicken weightening finish * 100% of the relative weight gain rate (%)=every average weight gain of test chicken/blank group
After the drug withdrawal 3 days, the medicine-feeding test chicken did not have obvious clinical symptoms, and the no typical cytopathic of inspection is cutd open in sampling, is judged to healing; Sx, anti-chicken excessively are effective in the therapeutic process.
The counteracting toxic substances dosimetry
After pressing counteracting toxic substances dosimetry result's 0.2ml counteracting toxic substances liquid counteracting toxic substances, except that normal healthy controls group and safe dose group, the counteracting toxic substances chicken all falls ill.
Counteracting toxic substances sequela symptom
30-35h behind the counteracting toxic substances infects the matched group chicken and falls ill successively, and symptoms such as performance spirit is depressed, pant, shed tears, sneeze occur dead behind the 98h.Sick chicken is cutd open the swelling of the visible chicken face of inspection, and eye conjunctivitis, nasal cavity catarrhal inflammation, trachea have the mucus exudate, air bag muddiness, bronchorrhagia, in mucus arranged, go out clot or cheesy thing.The chicken that dies of illness is positive through the sampling pathogen separation.
The curative effect of the smart powder of compound houttuynin
As can be seen from Table 2, test group chicken survival number, treatment effective percentage all are higher than medicine and positive controls, and 1 group and 2 groups all be higher than 3 groups, and test group the relative weight gain rate and control drug group difference are not remarkable, but be significantly higher than the infection matched group, prove that this medicine does not have the retarded growth phenomenon to chickling.
The smart powder of table 2 compound houttuynin is to the therapeutic effect of the compound respiratory tract disease of chicken
| Group | Test chicken number (only) | Medication sequela number (only) | Sickness rate (%) | Survival chicken number (only) | Effective percentage (%) | The relative weight gain rate (%) |
| High dose group, (1) dosage group in, (2) low dose group, (3) medicine contrast, (4) positive control, (5) negative control, (6) safe dose, (7) | 50 50 50 50 50 50 50 | 7 9 13 16 45 - - | 14 18 26 32 90 - 0 | 49 47 41 41 28 50 50 | 98 94 82 82 - - - | 96.24 92.35 88.71 86.27 74.68 100 98.75 |
Conclusion
The curative effect of the smart powder of compound houttuynin
Find out that from result of the test the sickness rate that the smart powder of compound houttuynin is 1 group, 2 groups, 3 groups is than the remarkable minimizing of positive controls, effective percentage is 98%-82%; The relative weight gain rate also significantly improves than positive controls.This is all significant for control and economic benefit that the chicken group mixes respiratory tract infection.The effective percentage of high, middle dosage group all is higher than 90%, is 0.625g//day so recommend clinical dosage, drinking-water, and 3-5 days is a course of treatment.
The safety testing of the smart powder of compound houttuynin
Show through safety testing (10 times of recommended dose are mixed drink, logotype 5 days), do not see clinical unusual performance between the operating period, healthy chicken is not had obvious influence, illustrate that this preparation is safe healthy chicken; And difference is compared in weightening finish with matched group not remarkable, so this medicine is to growth unrestraint effect.
The specific embodiment
Embodiment 1: get Herba Houttuyniae 583g, Radix Scutellariae 150g, Radix Isatidis 150g, Fructus Forsythiae 58g, Flos Lonicerae 58g; Get Herba Houttuyniae 200g and become fine powder with Fructus Forsythiae, Flos Lonicerae after pulverizing, remaining Herba Houttuyniae and Radix Scutellariae, Radix Isatidis decoct with water twice, each 2 hours, be merged into decocting liquid, filter, filtrate is condensed into thick paste, add above-mentioned fine powder, mixing, crushed after being dried promptly gets the smart powder of compound houttuynin.
Embodiment 2: Herba Houttuyniae 483g, Radix Scutellariae 124g, Radix Isatidis 124g, Fructus Forsythiae 48g, Flos Lonicerae 48g; Get Herba Houttuyniae 165g and become fine powder with Fructus Forsythiae, Flos Lonicerae after pulverizing, remaining Herba Houttuyniae and Radix Scutellariae, Radix Isatidis decoct with water twice, each 2 hours, collecting decoction filters, and filtrate is condensed into thick paste, add above-mentioned fine powder, mixing, crushed after being dried promptly gets the smart powder of compound houttuynin.
Be used for the treatment of diseases such as heating due to the flu that poultry cause because of affection due to external wind and heat, cough, pharyngalgia, have the effect of heat-clearing and toxic substances removing.Usage is spice or mixes drink, horse, cattle: 15-20g/ head/sky, and sheep, pig: 5-7g/ head/sky, spice, 3-5 days is a course of treatment; Poultry: 0.05-0.15g//day, mix drink, 3-5 days is a course of treatment.
Claims (2)
1, the smart powder of a kind of compound houttuynin of poultry use, it is characterized in that: the raw material by following part by weight is made:
Herba Houttuyniae 483-583g, Radix Scutellariae 124-150g, Radix Isatidis 124-150g, Fructus Forsythiae 48g-58g, Flos Lonicerae 48g-58g
Adopt following method to make: to get 1/3rd of used Herba Houttuyniae dosage, become fine powder with Fructus Forsythiae, Flos Lonicerae after pulverizing, remaining Herba Houttuyniae and Radix Scutellariae, Radix Isatidis decoct with water twice, each 2 hours, be merged into decocting liquid, filter, filtrate is condensed into thick paste, add above-mentioned fine powder, mixing, crushed after being dried promptly gets the smart powder of compound houttuynin.
2, the smart powder of the compound houttuynin of poultry use according to claim 1, it is characterized in that: the raw material by following weight preferred proportion is made:
Herba Houttuyniae 483g, Radix Scutellariae 124g, Radix Isatidis 124g, Fructus Forsythiae 48g, Flos Lonicerae 48g
Adopt following method to make: to get used Herba Houttuyniae 165g, become fine powder with Fructus Forsythiae, Flos Lonicerae after pulverizing, remaining Herba Houttuyniae and Radix Scutellariae, Radix Isatidis decoct with water twice, each 2 hours, be merged into decocting liquid, filter, filtrate is condensed into thick paste, add above-mentioned fine powder, mixing, crushed after being dried promptly gets the smart powder of compound houttuynin.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510015792 CN1958008A (en) | 2005-10-31 | 2005-10-31 | Animal use compound medicament with effects of removing toxic heat, and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510015792 CN1958008A (en) | 2005-10-31 | 2005-10-31 | Animal use compound medicament with effects of removing toxic heat, and preparation method |
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| CN1958008A true CN1958008A (en) | 2007-05-09 |
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| CN 200510015792 Pending CN1958008A (en) | 2005-10-31 | 2005-10-31 | Animal use compound medicament with effects of removing toxic heat, and preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102599381A (en) * | 2012-03-29 | 2012-07-25 | 常熟市润丰农业有限公司 | Meat chicken feed additive |
| CN102613408A (en) * | 2012-03-29 | 2012-08-01 | 江苏田娘农业科技有限公司 | Process for preparing traditional Chinese medicine health care lick blocks |
| CN104491124A (en) * | 2014-12-11 | 2015-04-08 | 河南牧翔动物药业有限公司 | Veterinary compound herba houttuyniae oral liquid and preparation method thereof |
| CN108013236A (en) * | 2017-12-01 | 2018-05-11 | 四川御鼎堂中药饮片有限公司 | A kind of feed for summer cultivation woods musk deer and preparation method thereof |
| CN109200097A (en) * | 2018-09-19 | 2019-01-15 | 洛阳汉德生物科技有限公司 | A kind of drug and preparation method thereof improving vaccine immunity uniformity |
-
2005
- 2005-10-31 CN CN 200510015792 patent/CN1958008A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102599381A (en) * | 2012-03-29 | 2012-07-25 | 常熟市润丰农业有限公司 | Meat chicken feed additive |
| CN102613408A (en) * | 2012-03-29 | 2012-08-01 | 江苏田娘农业科技有限公司 | Process for preparing traditional Chinese medicine health care lick blocks |
| CN102613408B (en) * | 2012-03-29 | 2014-04-30 | 常熟市慧丰塑料制品有限公司 | Process for preparing traditional Chinese medicine health care lick blocks |
| CN104491124A (en) * | 2014-12-11 | 2015-04-08 | 河南牧翔动物药业有限公司 | Veterinary compound herba houttuyniae oral liquid and preparation method thereof |
| CN104491124B (en) * | 2014-12-11 | 2017-06-30 | 河南牧翔动物药业有限公司 | Cordate houttuynia a kind of reed mentioned in ancient books indigo plant oral liquid for animals and preparation method thereof |
| CN108013236A (en) * | 2017-12-01 | 2018-05-11 | 四川御鼎堂中药饮片有限公司 | A kind of feed for summer cultivation woods musk deer and preparation method thereof |
| CN109200097A (en) * | 2018-09-19 | 2019-01-15 | 洛阳汉德生物科技有限公司 | A kind of drug and preparation method thereof improving vaccine immunity uniformity |
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