CN113350429A - Traditional Chinese medicine composition for preventing and treating African swine fever disease and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating African swine fever disease and preparation method and application thereof Download PDFInfo
- Publication number
- CN113350429A CN113350429A CN202110658399.2A CN202110658399A CN113350429A CN 113350429 A CN113350429 A CN 113350429A CN 202110658399 A CN202110658399 A CN 202110658399A CN 113350429 A CN113350429 A CN 113350429A
- Authority
- CN
- China
- Prior art keywords
- parts
- swine fever
- african swine
- preventing
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 101
- 208000007407 African swine fever Diseases 0.000 title claims abstract description 68
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 52
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 18
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 18
- 241001180876 Saposhnikovia Species 0.000 claims abstract description 17
- 235000006533 astragalus Nutrition 0.000 claims abstract description 17
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 17
- 235000011477 liquorice Nutrition 0.000 claims abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 17
- 240000001008 Dimocarpus longan Species 0.000 claims abstract description 15
- 235000000235 Euphoria longan Nutrition 0.000 claims abstract description 15
- 240000002262 Litsea cubeba Species 0.000 claims abstract description 15
- 235000012854 Litsea cubeba Nutrition 0.000 claims abstract description 15
- 241000237502 Ostreidae Species 0.000 claims abstract description 15
- 229940037003 alum Drugs 0.000 claims abstract description 15
- 235000020636 oyster Nutrition 0.000 claims abstract description 15
- 240000000377 Tussilago farfara Species 0.000 claims abstract description 14
- 235000004869 Tussilago farfara Nutrition 0.000 claims abstract description 14
- 241000382455 Angelica sinensis Species 0.000 claims abstract description 12
- 239000004480 active ingredient Substances 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 240000004980 Rheum officinale Species 0.000 claims abstract description 9
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 9
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 8
- 240000001398 Typha domingensis Species 0.000 claims abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims description 10
- 241000304195 Salvia miltiorrhiza Species 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 241001061264 Astragalus Species 0.000 claims description 9
- 210000004233 talus Anatomy 0.000 claims description 9
- 241000219061 Rheum Species 0.000 claims description 8
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims description 8
- 238000005303 weighing Methods 0.000 claims description 8
- 244000061520 Angelica archangelica Species 0.000 claims description 6
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- -1 premix Substances 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229940010454 licorice Drugs 0.000 claims 1
- 239000009910 sargent gloryvine Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 38
- 239000008280 blood Substances 0.000 abstract description 23
- 210000004369 blood Anatomy 0.000 abstract description 23
- 230000000694 effects Effects 0.000 abstract description 19
- 235000017276 Salvia Nutrition 0.000 abstract description 6
- 240000007164 Salvia officinalis Species 0.000 abstract description 6
- 206010011224 Cough Diseases 0.000 abstract description 4
- 208000006673 asthma Diseases 0.000 abstract description 4
- 230000003213 activating effect Effects 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 230000008961 swelling Effects 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract 1
- 241000282887 Suidae Species 0.000 description 34
- 238000012360 testing method Methods 0.000 description 20
- 201000010099 disease Diseases 0.000 description 16
- 241000282898 Sus scrofa Species 0.000 description 15
- 208000024891 symptom Diseases 0.000 description 13
- 206010037660 Pyrexia Diseases 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 240000000260 Typha latifolia Species 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 239000003053 toxin Substances 0.000 description 7
- 231100000765 toxin Toxicity 0.000 description 7
- 108700012359 toxins Proteins 0.000 description 7
- 230000036760 body temperature Effects 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- 208000032843 Hemorrhage Diseases 0.000 description 5
- 206010047700 Vomiting Diseases 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 238000000855 fermentation Methods 0.000 description 5
- 230000004151 fermentation Effects 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 239000000825 pharmaceutical preparation Substances 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 238000002791 soaking Methods 0.000 description 5
- 231100000419 toxicity Toxicity 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- 241000913745 Spatholobus Species 0.000 description 4
- 208000034158 bleeding Diseases 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 238000001647 drug administration Methods 0.000 description 4
- 235000021050 feed intake Nutrition 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000006996 mental state Effects 0.000 description 4
- 230000008673 vomiting Effects 0.000 description 4
- 241000721047 Danaus plexippus Species 0.000 description 3
- 206010014080 Ecchymosis Diseases 0.000 description 3
- 240000000249 Morus alba Species 0.000 description 3
- 235000008708 Morus alba Nutrition 0.000 description 3
- 240000008042 Zea mays Species 0.000 description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 235000005822 corn Nutrition 0.000 description 3
- 230000035622 drinking Effects 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 230000037406 food intake Effects 0.000 description 3
- 235000012631 food intake Nutrition 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 208000021760 high fever Diseases 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- SPFYMRJSYKOXGV-UHFFFAOYSA-N Baytril Chemical compound C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 SPFYMRJSYKOXGV-UHFFFAOYSA-N 0.000 description 2
- 244000080208 Canella winterana Species 0.000 description 2
- 235000008499 Canella winterana Nutrition 0.000 description 2
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 2
- 241000007126 Codonopsis pilosula Species 0.000 description 2
- 241000218176 Corydalis Species 0.000 description 2
- 244000301850 Cupressus sempervirens Species 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010014970 Ephelides Diseases 0.000 description 2
- 241001391115 Gelsemium elegans Species 0.000 description 2
- 241001135871 Gentiana scabra Species 0.000 description 2
- 240000007890 Leonurus cardiaca Species 0.000 description 2
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 description 2
- 208000003351 Melanosis Diseases 0.000 description 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 2
- 241000612118 Samolus valerandi Species 0.000 description 2
- 241000800405 Spatholobus suberectus Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 240000001949 Taraxacum officinale Species 0.000 description 2
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 229940107666 astragalus root Drugs 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 229940017545 cinnamon bark Drugs 0.000 description 2
- 238000005034 decoration Methods 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 229960000740 enrofloxacin Drugs 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000001165 lymph node Anatomy 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 229960000329 ribavirin Drugs 0.000 description 2
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 241000701386 African swine fever virus Species 0.000 description 1
- 241000205585 Aquilegia canadensis Species 0.000 description 1
- 235000008658 Artemisia capillaris Nutrition 0.000 description 1
- 241000092668 Artemisia capillaris Species 0.000 description 1
- 244000189799 Asimina triloba Species 0.000 description 1
- 235000006264 Asimina triloba Nutrition 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 235000009467 Carica papaya Nutrition 0.000 description 1
- 240000008444 Celtis occidentalis Species 0.000 description 1
- 235000018962 Celtis occidentalis Nutrition 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 244000037364 Cinnamomum aromaticum Species 0.000 description 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 1
- 244000183685 Citrus aurantium Species 0.000 description 1
- 235000007716 Citrus aurantium Nutrition 0.000 description 1
- 240000007126 Citrus medica var. sarcodactylis Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 235000009917 Crataegus X brevipes Nutrition 0.000 description 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 description 1
- 235000009685 Crataegus X maligna Nutrition 0.000 description 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 description 1
- 235000009486 Crataegus bullatus Nutrition 0.000 description 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 description 1
- 235000009682 Crataegus limnophila Nutrition 0.000 description 1
- 240000000171 Crataegus monogyna Species 0.000 description 1
- 235000004423 Crataegus monogyna Nutrition 0.000 description 1
- 235000002313 Crataegus paludosa Nutrition 0.000 description 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- 241001226187 Cyrtomium fortunei Species 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000195955 Equisetum hyemale Species 0.000 description 1
- 241000308663 Eupatorium fortunei Species 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 206010017999 Gastrointestinal pain Diseases 0.000 description 1
- 241000096284 Gynochthodes officinalis Species 0.000 description 1
- 206010019842 Hepatomegaly Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241000334160 Isatis Species 0.000 description 1
- 244000062241 Kaempferia galanga Species 0.000 description 1
- 235000013421 Kaempferia galanga Nutrition 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 241000717679 Mosla Species 0.000 description 1
- 108010043958 Peptoids Proteins 0.000 description 1
- 241000972673 Phellodendron amurense Species 0.000 description 1
- 244000171085 Polyporus umbellatus Species 0.000 description 1
- 235000004837 Polyporus umbellatus Nutrition 0.000 description 1
- 240000004064 Poterium sanguisorba Species 0.000 description 1
- 235000008291 Poterium sanguisorba Nutrition 0.000 description 1
- 241000206469 Pulsatilla Species 0.000 description 1
- 241000025505 Pyrrosia Species 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 241000235342 Saccharomycetes Species 0.000 description 1
- 235000008282 Sanguisorba officinalis Nutrition 0.000 description 1
- 240000002800 Sanicula europaea Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 241000219784 Sophora Species 0.000 description 1
- 240000007641 Spergula rubra Species 0.000 description 1
- 206010041660 Splenomegaly Diseases 0.000 description 1
- 244000089698 Zanthoxylum simulans Species 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 208000027503 bloody stool Diseases 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000004373 mandible Anatomy 0.000 description 1
- 239000010446 mirabilite Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 210000002741 palatine tonsil Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000008113 selfheal Nutrition 0.000 description 1
- 230000009528 severe injury Effects 0.000 description 1
- 230000005982 spleen dysfunction Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating African swine fever diseases and a preparation method and application thereof. The traditional Chinese medicine composition contains active ingredients, wherein the active ingredients are prepared from dried alum, longan, liquorice, coltsfoot flower, divaricate saposhnikovia root, cattail pollen, red-rooted salvia root, astragalus mongholicus, litsea cubeba, caulis spatholobi, rheum officinale, oyster and angelica sinensis. The medicines are combined to be synergistic, and have the effects of clearing away heat and toxic materials, enriching blood and activating blood, removing stasis and reducing swelling, and relieving cough and asthma. Can be effectively used for preventing and treating African swine fever diseases, and has the advantages of wide raw material source, safety, environmental protection, simple preparation process, low production cost and the like.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition, and particularly relates to a traditional Chinese medicine composition for preventing and treating African swine fever diseases, and a preparation method and application thereof.
Background
African swine fever is an acute, febrile and highly contagious animal infectious disease of domestic pigs and wild pigs caused by African swine fever virus, and pigs of all breeds and all ages can be infected, and the morbidity and mortality can reach 100%. The world animal health organization lists African swine fever as an animal epidemic disease reported by the legal system, and China also lists African swine fever as a type of animal epidemic disease. About 100 years of history is found in African Kenya for the first time from 1921, African swine fever is found in China for the first time in 2018, the swine fever is scanned across the country in a few months, and the loss caused by the swine fever is far more than that caused by other epidemic diseases. Therefore, it is very important to find an effective method for preventing and treating African swine fever.
African swine fever may enter the pig body through the upper respiratory system and mouth, and may cause infection in the nasopharynx or tonsil. The virus spreads rapidly to the lymph nodes of the mandible and then spreads throughout the body through the lymph and blood. The natural infection latency period is about 5-9 days, which is often shorter, the clinical experiment infection period is about 2-5 days, the disease process is also shorter, the clinical manifestations are fever (body temperature reaches 40-42 ℃), dyspnea, heartbeat is accelerated, some pigs are accompanied by cough symptoms, the nose and eyes have serous or mucoid purulent secretion, gastrointestinal mucosa, kidney and lymph node obviously have bleeding symptoms, and skin cyanosis.
At present, no vaccine for effectively preventing the African swine fever exists at home and abroad, and no specific medicine for treating the African swine fever exists. Therefore, the biological safety prevention and control of the pig farm is well done, and the control of the propagation path is very key; however, the enhancement of the immunity of the swine herd of the susceptible animals, the supplementation of qi and blood of the swine and the improvement of the infection threshold of the susceptible animals are more important measures for preventing and controlling the African swine fever.
Disclosure of Invention
In order to solve the technical problems, the invention provides a traditional Chinese medicine composition for preventing and treating African swine fever diseases.
The traditional Chinese medicine composition contains active ingredients, and the active ingredients are prepared from dried alum, longan, liquorice, coltsfoot flower, divaricate saposhnikovia root, cattail pollen, red-rooted salvia root, astragalus mongholicus, litsea cubeba, caulis spatholobi, rheum officinale, oyster and angelica sinensis.
Further, the active ingredients are prepared from 5-25 parts of dried alum, 10-50 parts of longan, 20-60 parts of liquorice, 10-40 parts of flos farfarae, 10-50 parts of divaricate saposhnikovia root, 20-80 parts of pollen typhae, 10-30 parts of salvia miltiorrhiza, 20-60 parts of astragalus, 10-50 parts of litsea cubeba, 20-80 parts of caulis spatholobi, 5-20 parts of rheum officinale, 6-18 parts of oyster and 5-20 parts of angelica sinensis by weight.
Further, the active ingredients are prepared from 10-20 parts by weight of dried alum, 20-40 parts by weight of longan, 30-50 parts by weight of liquorice, 15-25 parts by weight of coltsfoot flower, 20-40 parts by weight of divaricate saposhnikovia root, 40-60 parts by weight of cattail pollen, 15-25 parts by weight of salvia miltiorrhiza, 30-50 parts by weight of astragalus, 25-45 parts by weight of litsea cubeba, 40-60 parts by weight of spatholobus stem, 8-14 parts by weight of rhubarb, 8-14 parts by weight of oyster and 8-15 parts by weight of angelica.
Furthermore, the active ingredients are prepared from 15 parts of dried alum, 30 parts of longan, 40 parts of liquorice, 20 parts of coltsfoot flower, 30 parts of divaricate saposhnikovia root, 50 parts of cattail pollen, 20 parts of salvia miltiorrhiza, 40 parts of astragalus, 35 parts of litsea cubeba, 50 parts of caulis spatholobi, 10 parts of rhubarb, 10 parts of oyster and 10 parts of angelica by weight.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for preventing and treating African swine fever diseases, which comprises the following steps:
(1) weighing the raw materials in a weight ratio;
(2) pulverizing the above medicinal materials, sieving, or extracting with water or alcohol, concentrating, and adding pharmaceutically acceptable adjuvants or adjuvant ingredients.
The preparation form of the traditional Chinese medicine composition for preventing and treating the African swine fever disease prepared by the preparation method can be as follows: powder, premix, powder, granule or oral liquid.
Furthermore, the particle size of the traditional Chinese medicine composition powder for preventing and treating African swine fever diseases prepared by the preparation method is below 50 microns.
The invention also provides application of the traditional Chinese medicine composition in preventing and treating African swine fever diseases.
In particular to a medicine for preventing and treating African swine fever disease prepared from the traditional Chinese medicine composition.
Further, the invention also provides a feed containing the traditional Chinese medicine composition.
The medicine of the invention has the advantages and beneficial effects that:
the components and the dosage of the traditional Chinese medicine composition are obtained by repeated verification and practice of a large number of experiments according to the dialectical treatment theory of Chinese veterinary medicine formulas. The patent prescription of the invention is an accurate prescription obtained by combining pathogenesis and clinical symptoms of African swine fever and verifying a large number of clinical effects under the guidance of the theory of treatment by differentiation of syndromes of traditional Chinese medicine, and has good prevention and treatment effects on the African swine fever.
The medicine of the invention exerts the holistic concept and dialectical treatment theory of traditional Chinese medicine and can effectively prevent and treat African swine fever diseases. The African swine fever belongs to pestilence in traditional Chinese medicine, and the epidemic disease theory states that the pestilence qi … … affecting the world is introduced from the mouth and nose, so that the pestilence qi is not in the viscera, not in the meridians and collaterals, in the latent backbone, and is not far from the exterior, and the neighborhood is in the stomach, which is the boundary between the exterior and the interior, and is half exterior and half interior. Therefore, the sick pigs only have the symptoms of persistent high fever and diarrhea clinically. Emesis is the first clinically manifested symptom of african swine fever. When a pig suffering from African swine fever is dissected in a laboratory, the affected pig can be seen to have a large amount of blood accumulation in the chest cavity, enlarged liver and spleen, and a peptoid substance in the abdominal cavity of intestinal tract, and the analysis from the traditional Chinese medicine point of view is to be caused by spleen dysfunction and transportation and damp-heat imbalance. The onset of epidemic diseases requires rapid removal of toxins, clearing of heat toxins, reduction of viscera injuries and rapid recovery of normal functions of the organism. When the disease progresses from the half exterior to the half interior and falls into the interior, the interior syndrome and the healthy qi in the body compete with each other, so that the disease may lead to too fast invasion, acute death and severe damage to the zang-fu organs. Excessive toxic heat can cause bleeding and consumption, leading to yin impairment and qi collapse, and finally death. While the liver stores blood, heart governs blood, and heat disturbs heart spirit. So the body is hot, the blood circulation is not smooth, and the blood overflows outside the vessels, and hematochezia, hemorrhage and hematuria appear; heat toxin consumes body fluids in blood, causing stagnation of qi and blood, blood stasis, and ecchymosis will occur in animal body. At this time, a large amount of medicines for clearing heat and removing toxicity, cooling blood and removing freckles are used inevitably, so that heat toxin is eliminated, and simultaneously, the original qi of the spleen and the kidney is prevented from being damaged. However, the heat with dampness is not suitable for clearing heat alone, and the dampness with heat is not easy to dry alone. Therefore, the traditional Chinese medicine composition has the effects of clearing heat and removing toxicity, eliminating dampness, enriching blood and activating blood, removing blood stasis and reducing swelling, tonifying yin and restoring yang, eliminating turbid qi, clearing heat and toxicity, finally enabling an organism to quickly discharge virus endotoxin, clearing heat and toxicity, recovering qi and blood, improving immunity and the like.
In the invention, astragalus, caulis spatholobi and pollen typhae are used as monarch drugs and have the effects of enhancing immunity, clearing toxin, reducing bleeding, removing ecchymosis, prolonging blood coagulation time and the like, and the african swine fever is weak in nutrient and qi and cannot promote blood circulation, and hot blood is recklessly circulated outside channels and collaterals, so that bleeding macula is generated, so that the three medicines of the astragalus, the caulis spatholobi and the pollen typhae are used for promoting qi circulation and regulating blood, and eliminating ecchymosis and promoting eruption; the liquorice, the angelica, the salvia miltiorrhiza and the longan are used as ministerial drugs, and have the effects of enriching and activating blood, relaxing bowel, cooling blood and eliminating carbuncle and reducing intestinal spasm, and the effects of promoting the circulation of qi and blood, eliminating freckles and promoting eruption of the monarch drugs; the divaricate saposhnikovia root, the litsea cubeba and the common coltsfoot flower are used as adjuvant drugs, have the effects of strengthening the spleen, regulating the flow of qi, eliminating dampness, relieving asthma, dispelling wind, dispelling cold and relieving cough and asthma, further regulate the balance of the organism and enable monarch drugs and ministerial drugs to better play a role; rhubarb, oyster, dried alum and partial liquorice are used as guiding drugs, and have the effects of dissolving phlegm, eliminating dampness, stopping diarrhea and harmonizing the drugs, and the high-heat area of African swine fever belongs to the interior excess syndrome of heat toxin, and then heat is cleared away to promote the production of body fluid, and fire is discharged to remove toxin; heat retention in the intestinal tract: clearing heat and purging fire, increasing fluid and relaxing bowels. The medicines are combined to be synergistic, and have the effects of promoting the circulation of qi and regulating blood, eliminating spots and promoting eruption, purging heat and removing toxicity, clearing heat and accumulating intestinal tract, cooling blood and removing food retention, and relieving cough and asthma.
In addition, the raw materials of the medicine are wide in source and low in cost, compared with the prior art, the medicine greatly saves the medicine cost, and the test verifies that the medicine has obvious effect of preventing and treating the African swine fever.
In addition, the traditional Chinese medicine is prepared by adopting the modern pharmaceutical technology, can be quickly absorbed in the animal body to exert the drug effect, can be intensively administered in different modes, and is beneficial to the group prevention and mass treatment of the African swine fever diseases.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
EXAMPLE 1 pharmaceutical preparation and use of the invention
(1) Weighing the following raw materials by weight:
5 parts of dried alum, 10 parts of longan, 20 parts of liquorice, 10 parts of coltsfoot flower, 10 parts of divaricate saposhnikovia root, 20 parts of cattail pollen, 10 parts of red-rooted salvia root, 20 parts of astragalus root, 10 parts of litsea cubeba, 20 parts of spatholobus suberectus, 5 parts of rhubarb, 6 parts of oyster and 5 parts of angelica.
(2) Micronizing the raw medicinal materials weighed in the step (1), fully and uniformly mixing, and preparing into powder.
(3) The application method of the medicine comprises the following steps: the feed is used for preventing and treating African swine fever diseases and is mixed with: 1kg of the traditional Chinese medicine is added into 1 ton of feed for 7-10 days.
Example 2 pharmaceutical preparation and use of the invention
(1) Weighing the following raw materials by weight:
25 parts of dried alum, 50 parts of longan, 60 parts of liquorice, 40 parts of coltsfoot flower, 50 parts of divaricate saposhnikovia root, 80 parts of cattail pollen, 30 parts of salvia miltiorrhiza, 60 parts of astragalus, 50 parts of litsea cubeba, 80 parts of spatholobus suberectus, 20 parts of rheum officinale, 18 parts of oyster and 20 parts of angelica.
(2) Coarsely crushing the raw medicinal materials weighed in the step (1) according to the weight ratio, soaking the medicinal materials in distilled water for 0.5h, decocting for 3 times, decocting for 2 hours for the first time, and soaking for 1.0h for the second time and the third time respectively, combining the filtrates, concentrating into a thick paste, adding a proper amount of starch, dextrin and 5% citric acid (or other auxiliary materials), uniformly mixing, granulating, drying, and preparing into granules (each 1g is equivalent to 2g of the crude medicinal materials).
(3) The application method of the medicine comprises the following steps: the product is used for preventing and treating African swine fever diseases, and is mixed with drinking: 0.5kg of the medicine is added into 1 ton of water and is freely drunk for 7 to 10 days continuously.
Example 3 pharmaceutical preparation and use of the invention
(1) Weighing the following raw materials by weight:
10 parts of dried alum, 20 parts of longan, 30 parts of liquorice, 15 parts of common coltsfoot flower, 20 parts of divaricate saposhnikovia root, 40 parts of cattail pollen, 15 parts of red-rooted salvia root, 30 parts of astragalus, 25 parts of litsea cubeba, 40 parts of spatholobus stem, 8 parts of rhubarb, 8 parts of oyster and 8 parts of Chinese angelica.
(2) Coarsely crushing the raw medicinal materials weighed in the step (1) according to the weight ratio, soaking the medicinal materials in distilled water for 0.5h, decocting for 3 times, wherein the first time is 1.5 h, and the second time and the third time are 1.0h respectively, combining the filtrates, concentrating into thick paste, adding a proper amount of starch, dextrin and 5% citric acid (or other auxiliary materials), uniformly mixing, and performing spray drying to prepare powder (each 1g is equivalent to 2g of the original medicinal materials).
(3) The application method of the medicine comprises the following steps: the feed is used for preventing and treating African swine fever diseases, and is mixed with feed, 0.5-1kg of the traditional Chinese medicine is added into each 1 ton of feed, and the traditional Chinese medicine is used for 7-10 days.
Example 4 pharmaceutical preparation and use of the invention
(1) Weighing the following raw materials by weight:
20 parts of dried alum, 40 parts of longan, 50 parts of liquorice, 25 parts of common coltsfoot flower, 40 parts of divaricate saposhnikovia root, 60 parts of cattail pollen, 25 parts of red-rooted salvia root, 50 parts of astragalus, 45 parts of litsea cubeba, 60 parts of spatholobus stem, 14 parts of rhubarb, 14 parts of oyster and 15 parts of Chinese angelica.
(2) Coarsely crushing the raw medicinal materials weighed in the step (1) according to the weight ratio, soaking the medicinal materials in distilled water for 0.5h, decocting for 3 times, wherein the first time is 1.5 h, and the second time and the third time are 1.0h respectively, combining the filtrates, and concentrating to a certain volume (equivalent to 1g/ml of the traditional Chinese medicine); adding ethanol into the concentrated solution to make ethanol content 70%, filtering, recovering ethanol from the filtrate, concentrating to 2g per 1ml, filtering, bottling, and sterilizing to obtain oral liquid.
(3) The application method of the medicine comprises the following steps: the product is used for preventing and treating African swine fever diseases, and is mixed with drinking: 1000ml of the medicine is added into every 1 ton of water, and the medicine is freely drunk and is continuously used for 7 to 10 days.
Example 5 pharmaceutical preparation and use of the invention
(1) Weighing the following raw materials by weight:
15 parts of dried alum, 30 parts of longan, 40 parts of liquorice, 20 parts of common coltsfoot flower, 30 parts of divaricate saposhnikovia root, 50 parts of cattail pollen, 20 parts of red-rooted salvia root, 40 parts of astragalus root, 35 parts of litsea cubeba, 50 parts of spatholobus stem, 10 parts of rhubarb, 10 parts of oyster and 10 parts of Chinese angelica.
(2) Coarsely crushing the raw medicinal materials weighed in the step (1) according to the weight ratio, soaking the medicinal materials in distilled water for 0.5h, decocting for 3 times, wherein the first time is 1.5 h, and the second time and the third time are 1.0h respectively, combining the filtrates, and concentrating to a certain volume (equivalent to 1.0g/ml of the traditional Chinese medicine); adding ethanol into the concentrated solution to make ethanol content 70%, filtering, recovering ethanol from the filtrate, concentrating to 2g per 1ml, filtering, bottling, and sterilizing to obtain oral liquid.
(3) The application method of the medicine comprises the following steps: the product is used for preventing and treating African swine fever diseases, and is mixed with drinking: 1000mL of the medicine is added into 1 ton of water, and the medicine is freely drunk and is continuously used for 7 to 10 days.
In order to show the prevention and treatment effect of the drug on the African swine fever disease, the drug is subjected to clinical efficacy observation tests, and the beneficial effects of the drug are further illustrated by test examples.
Comparative example 1
A traditional Chinese medicine preparation for preventing and treating African swine fever comprises the following components in parts by weight: 10 parts of gelsemium elegans, 6 parts of codonopsis pilosula, 3 parts of divaricate saposhnikovia root, 16 parts of mulberry leaf, 2 parts of cinnamon bark, 3 parts of golden cypress, 2 parts of Chinese angelica, 10 parts of motherwort, 2 parts of rheum officinale, 8 parts of astragalus membranaceus, 4 parts of radix scutellariae, 5 parts of dandelion, 1.5 parts of rhizoma atractylodis, 5 parts of gentiana scabra bunge, 3 parts of bunge corydalis herb and 4 parts of liquorice.
The preparation method of the traditional Chinese medicine preparation for preventing and treating African swine fever comprises the following steps: weighing the above raw materials, pulverizing, and oven drying.
Comparative example 2
A traditional Chinese medicine fermentation preparation for preventing and treating African swine fever comprises the following components in parts by weight: 10 parts of gelsemium elegans, 6 parts of codonopsis pilosula, 3 parts of divaricate saposhnikovia root, 16 parts of mulberry leaf, 2 parts of cinnamon bark, 3 parts of golden cypress, 2 parts of Chinese angelica, 10 parts of motherwort, 2 parts of rheum officinale, 8 parts of astragalus membranaceus, 4 parts of radix scutellariae, 5 parts of dandelion, 1.5 parts of rhizoma atractylodis, 5 parts of gentiana scabra bunge, 3 parts of bunge corydalis herb and 4 parts of liquorice.
The preparation method of the traditional Chinese medicine fermentation preparation for preventing and treating African swine fever comprises the following steps: the raw materials are coarsely crushed, 5 parts of corn starch and fermentation strains (1 part of saccharomycetes, 1 part of lactobacillus and 2 parts of bacillus subtilis) are added with water to adjust the water content to be 40 percent and are uniformly stirred, the corn and the puffed corn are alternately placed in a closed fermentation tank layer by layer for fermentation for 9 days, and then the multivitamins and the brown sugar are added to obtain the corn feed.
Comparative example 3
A medicine for treating swine high fever disease comprises the following components in parts by weight: 45 parts of honeysuckle stem, 26 parts of isatis root, 26 parts of subprostrate sophora, 26 parts of ginger, 26 parts of Chinese mosla herb, 26 parts of mulberry leaf, 26 parts of chrysanthemum, 26 parts of common scouring rush herb, 26 parts of garden burnet root, 35 parts of glauber salt, 75 parts of Chinese pulsatilla root, 26 parts of cassia seed, 26 parts of selfheal, 26 parts of cortex lycii radicis, 26 parts of Chinese angelica, 26 parts of starwort root, 26 parts of amur corktree bark, 26 parts of ash bark and 26 parts of katsumade galangal seed; 26 portions of hackberry; 26 parts of eupatorium fortunei, 20 parts of polyporus umbellatus, 26 parts of artemisia capillaris, 26 parts of pyrrosia leaf, 40 parts of zanthoxylum bungeanum maxim, 40 parts of raw hawthorn, 40 parts of radish seed, 26 parts of endothelium corneum gigeriae galli, 26 parts of immature bitter orange, 20 parts of fingered citron, 26 parts of rhizoma cyperi, 26 parts of salvia miltiorrhiza, 26 parts of astragalus membranaceus, 40 parts of rhizoma polygonati, 35 parts of cyrtomium fortunei, 26 parts of pawpaw, 26 parts of morinda officinalis and.
The preparation method of the medicine for treating swine high fever disease comprises the following steps: pulverizing the above materials, adding 5 ‰ probiotic powder into cold boiled water, dissolving, adding into the pulverized medicinal powder, stirring, kneading with hand until water is not dropped, sealing, fermenting for 9 days, and drying at 45 deg.C.
Test example 1
In 2020, 120 fat pigs in a pig farm in Shandong province are attacked from day 20 and 6 months, with symptoms of vomiting, fever, no food intake and bloody drawing, and are diagnosed as African swine fever positive by using a rapid test strip, the 120 sick pigs with the diseases are divided into 6 groups, the 1 st to 5 th groups are test groups, the 6 th group is a drug control group, the 1 st to 5 th groups are respectively administrated according to the methods of example 1, example 2, example 3, example 4 and example 5, and the 6 th group of the drug control group is treated by 20% of enrofloxacin injection and ribavirin injection for 5 days. The treatment was observed and recorded at any time and the mortality was counted after 1 week for 1 month of administration of the drug, the total effective rate and cure rate were counted and the results are shown in table 1. The patient does not have fever, has no bloody stool, starts to eat and judges that the mental state becomes good to be effective. Good spirit, normal feed intake and normal feces are judged to be cured.
TABLE 1 therapeutic Effect of the drugs of the present invention on African swine fever
As can be seen from Table 1, compared with the drug control group, the drug test groups 1-5 of the invention can greatly improve the survival rate of the swine suffering from African swine fever, and the drug of the invention has obvious curative effect on the treatment of the African swine fever.
Test example 2
In 7 months in 2019, 800 fattening pigs in a certain farm in Fujian have the average weight of 45kg, and the pigs begin to get ill in the early 8 months, so that the symptoms of fever, bloodiness, vomiting and no eating are presented. 26 dead pigs, 150 sick pigs and 624 pigs without clinical symptoms; the test paper strip is used for detecting that the African swine fever is positive, the African swine fever disease is confirmed through veterinary clinic, 150 sick pigs which are ill and survive are randomly divided into 3 groups, 50 pigs in each group are respectively treated by administration, the drug administration of the first group is carried out by using the drug prepared in the embodiment 3, and the drug administration lasts for 10 days; the second group was administered with the drug prepared in example 5 for 10 consecutive days; the third group is treated by 20 percent enrofloxacin injection and ribavirin injection, the administration is continuously carried out for 10 days, and the administration effect is observed after 10 days; 624 pigs which did not develop disease were isolated in time and then administered prophylactically, and the drug and method prepared in example 5 were used, and the effect of the drug was observed after 10 days, and the results are shown in table 2. In the disease test group, effective judgment criteria are as follows: the body temperature returns to normal, food intake is started, and the mental state is judged to be effective after being recovered. The judgment standard of cure is as follows: normal body temperature, normal feed intake, good mental status and normal feces.
TABLE 2 therapeutic Effect of the drugs of the present invention on African swine fever
As can be seen from Table 2, the drug of the present invention has significant effect on the treatment of African swine fever. And test 2 group had the best results, with the optimal prescription of the present invention.
Test example 3
In 8 months in 2019, 1000 fattening pigs fed by Wangzhi of Gansu land have the average weight of 40kg, and the pigs begin to get ill in the early 9 months, and have the symptoms of fever, bloodiness, vomiting and no eating. 35 dead pigs, 200 sick pigs and 765 pigs without clinical symptoms; the test paper strip is used for detecting that the African swine fever is positive, the African swine fever disease is confirmed through veterinary clinical diagnosis, 200 sick pigs which survive the disease and 765 pigs which do not have clinical symptoms are separately fed, the 200 sick pigs are treated and administrated, the medicine and the administration method which do not have the disease are used for administration, and the medicine and the administration method which are prepared in the embodiment 5 are used for 10 days. After half a month, the service staff visits, except that 2 pigs of 200 pigs which are treated and administrated die within 2 days of administration, the other surviving pigs have normal body temperature, normal feed intake and good mental state. The diseased pig has the positive result even if the African swine fever is detected, and the growth of the pig is not influenced. The feedback of the Wangzhi shows that the medicine has good treatment and prevention effects on the African swine fever diseases.
Test example 4
In the 5 th month of 2021, 500 nursery pigs in Jiangxi Jian pig farm weigh 30kg averagely, and the diseases begin to occur at the beginning of the month, and symptoms of fever, bloodiness, vomiting and no eating are presented. 30 dead pigs, 150 sick pigs and 320 pigs without clinical symptoms; the test paper strip is used for detecting that the African swine fever is positive, 150 sick pigs which survive the disease are divided into 5 groups, 35 pigs in each group of a test 1 group-a test 4 group and 10 pigs in a test 5 group, administration treatment is respectively carried out, the drug administration of the drug prepared in the example 5 in the test 1 group is carried out, and the drug administration lasts for 10 days; experiment 2 group was administered with the drug prepared in comparative example 1 mixed feed, 3 kg per ton of feed was added, and the drug was taken freely and continuously for 10 days; experiment 3 groups were administered with the drug prepared in comparative example 2 mixed with 10 kg per ton of feed, taken freely, and administered continuously for 10 days; experiment 4 groups were administered with the drug prepared in comparative example 3 mixed feed, 10 kg per ton of feed was added, and the drug was taken freely and administered continuously for 10 days; test 5 groups were used as blank control groups without any treatment, other feeding conditions were substantially identical, and the effect of the drug was observed after 10 days. The non-diseased pigs were isolated in time and then administered prophylactically, with the drug and method prepared in example 5, and the effect was observed after 10 days, with the results shown in table 2. In the disease test group, effective judgment criteria are as follows: the body temperature returns to normal, food intake is started, and the mental state is judged to be effective after being recovered. The judgment standard of cure is as follows: normal body temperature, normal feed intake, good mental status and normal feces.
TABLE 3 therapeutic Effect of the drugs of the present invention on African swine fever
As can be seen from Table 3, the drugs of the present invention and the comparative drugs were effective in treating African swine fever, compared with the blank control group. The effect of the medicine for treating African swine fever is obvious and is far better than that of a comparative example medicine.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the technical principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. A Chinese medicinal composition for preventing and treating African swine fever diseases is characterized by comprising active ingredients, wherein the active ingredients are prepared from dried alum, longan, liquorice, coltsfoot flower, divaricate saposhnikovia root, cattail pollen, salvia miltiorrhiza, astragalus, litsea cubeba, sargentgloryvine stem, rhubarb, oyster and angelica.
2. The traditional Chinese medicine composition for preventing and treating African swine fever diseases according to claim 1, wherein the active ingredients are prepared from 5-25 parts of dried alum, 10-50 parts of longan, 20-60 parts of liquorice, 10-40 parts of tussilago farfara, 10-50 parts of divaricate saposhnikovia root, 20-80 parts of cattail pollen, 10-30 parts of Salvia miltiorrhiza, 20-60 parts of Astragalus mongholicus, 10-50 parts of litsea cubeba, 20-80 parts of caulis spatholobi, 5-20 parts of rheum officinale, 6-18 parts of oyster and 5-20 parts of Angelica sinensis.
3. The traditional Chinese medicine composition for preventing and treating African swine fever diseases according to claim 2, wherein the active ingredients are prepared from 10-20 parts of dried alum, 20-40 parts of longan, 30-50 parts of liquorice, 15-25 parts of tussilago farfara, 20-40 parts of divaricate saposhnikovia root, 40-60 parts of cattail pollen, 15-25 parts of Salvia miltiorrhiza, 30-50 parts of Astragalus mongholicus, 25-45 parts of litsea cubeba, 40-60 parts of caulis spatholobi, 8-14 parts of rheum officinale, 8-14 parts of oyster and 8-15 parts of Angelica sinensis.
4. The traditional Chinese medicine composition for preventing and treating African swine fever diseases according to claim 3, wherein the active ingredients are prepared from dried alum 15, longan 30, licorice 40, tussilago farfara 20, divaricate saposhnikovia root 30, cattail pollen 50, Salvia miltiorrhiza 20, Astragalus mongholicus 40, litsea cubeba 35, caulis spatholobi 50, rheum officinale 10, oyster 10 and Angelica sinensis 10.
5. A preparation method of the traditional Chinese medicine composition for preventing and treating African swine fever diseases according to any one of claims 1-4, which is characterized by comprising the following steps:
(1) weighing the raw materials in a weight ratio;
(2) pulverizing the above medicinal materials, sieving, or extracting with water or alcohol, concentrating, and adding pharmaceutically acceptable adjuvants or adjuvant ingredients.
6. The method for preparing a Chinese medicinal composition for preventing and treating African swine fever disease according to claim 5, wherein the prepared dosage form comprises powder, premix, powder, granules or oral liquid.
7. The preparation method of the traditional Chinese medicine composition for preventing and treating African swine fever disease according to claim 6, wherein the particle size of the powder is below 50 microns.
8. The use of the Chinese medicinal composition for preventing and treating African swine fever disease according to any one of claims 1-4 in the preparation of a medicament for preventing and treating African swine fever disease.
9. The use of the Chinese medicinal composition for preventing and treating African swine fever disease according to any one of claims 1-4 in the preparation of feed for preventing and treating African swine fever disease.
10. Feed containing the traditional Chinese medicine composition for preventing and treating African swine fever diseases according to any one of claims 1-4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110658399.2A CN113350429B (en) | 2021-06-15 | 2021-06-15 | Traditional Chinese medicine composition for preventing and treating African swine fever disease as well as preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110658399.2A CN113350429B (en) | 2021-06-15 | 2021-06-15 | Traditional Chinese medicine composition for preventing and treating African swine fever disease as well as preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113350429A true CN113350429A (en) | 2021-09-07 |
| CN113350429B CN113350429B (en) | 2024-03-12 |
Family
ID=77534110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110658399.2A Active CN113350429B (en) | 2021-06-15 | 2021-06-15 | Traditional Chinese medicine composition for preventing and treating African swine fever disease as well as preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113350429B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114209748A (en) * | 2021-12-22 | 2022-03-22 | 河南省中兽医药研究院有限公司 | Traditional Chinese medicine composition for preventing African swine fever and application and preparation thereof |
-
2021
- 2021-06-15 CN CN202110658399.2A patent/CN113350429B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 张吉鹍: "非洲猪瘟背景下，药食同源中草药黄芪多糖提升猪只抗病力的营养活性作用", 猪业科学, vol. 37, no. 12, pages 81 * |
| 陈茂存: "慢性猪瘟与温和型猪瘟的中兽医论治", 中兽医学杂志, no. 3, pages 35 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114209748A (en) * | 2021-12-22 | 2022-03-22 | 河南省中兽医药研究院有限公司 | Traditional Chinese medicine composition for preventing African swine fever and application and preparation thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113350429B (en) | 2024-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102846866B (en) | Chinese medicine composition for prevention and control of porcine circovirus disease and preparation method thereof | |
| CN110624094A (en) | Traditional Chinese medicine composition for treating and preventing African swine fever | |
| CN100352463C (en) | Compound Chinese medicine for treating child diarrhea and its preparation method | |
| WO2020155318A1 (en) | Traditional chinese medicine preparation for treatment of bacterial respiratory tract disease in livestock and production technique thereof | |
| CN109646550A (en) | A kind of Chinese medicine composition and preparation method thereof treated and/or prevent African swine fever | |
| CN113350429B (en) | Traditional Chinese medicine composition for preventing and treating African swine fever disease as well as preparation method and application thereof | |
| CN104840695A (en) | Medicine combination for treating white scour of piglet and preparation method thereof | |
| CN103041048B (en) | Traditional Chinese medicine composition for treating animal enteritis and diarrhea and preparation method of same | |
| CN116139237A (en) | A Chinese medicinal composition for preventing and treating respiratory tract infection caused by coronavirus, and its application | |
| CN1958023A (en) | Animal use compound medicament with effects for invigorating qi, strengthening the superficial, dispelling wind-evil, and being sensible, and preparation method | |
| CN104825753B (en) | A kind of Chinese medicine composition for prevention newborn piglet diarrhea of being taken medicine by sow | |
| CN113599430A (en) | Livestock diarrhea treatment prescription and preparation method thereof | |
| CN111905034A (en) | Traditional Chinese medicine composition for preventing and treating African swine fever and preparation method thereof | |
| CN105250552A (en) | Pharmaceutical preparation used for treating acute gastroenteritis | |
| CN105169327B (en) | A kind of pharmaceutical composition and preparation method thereof for treating porcine diarrhea disease | |
| CN103816265B (en) | A kind ofly be used for the treatment of medicine of having loose bowels and preparation method thereof | |
| CN106620266A (en) | Traditional Chinese medicine composition for treating mycoplasmal pneumonia of swine | |
| CN103690771B (en) | Be used for the treatment of medicine of lamb colibacillosis and preparation method thereof | |
| CN106620140A (en) | Traditional Chinese medicine composition for treating foot rot of buffaloes | |
| CN108144037B (en) | Traditional Chinese medicine composition for treating cough and application thereof | |
| CN106729589A (en) | Treat the Chinese medicine preparation and preparation method of transmissible gastroenteritis of swine | |
| CN106492016A (en) | A kind of compound Chinese medicinal preparation of anti-pig blue-ear disease and preparation method thereof | |
| CN104491505A (en) | Compound fermented coptis chinensis paste and preparation method thereof | |
| CN101085048A (en) | Traditional Chinese medicine for detoxicating for animals and preparation method thereof | |
| CN113209011A (en) | Traditional Chinese medicine oral liquid for preventing and treating porcine viral diarrhea diseases and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20220718 Address after: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Applicant after: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Applicant after: Shaoshan Da Bei Nong Animal Pharmaceutical Co., Ltd. Address before: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Applicant before: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Applicant before: Shaoshan Dabeinong Animal Medicine Co.,Ltd. Applicant before: BEIJING DABEINONG TECHNOLOGY GROUP Co.,Ltd. |
|
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |