CN104825753B - A kind of Chinese medicine composition for prevention newborn piglet diarrhea of being taken medicine by sow - Google Patents
A kind of Chinese medicine composition for prevention newborn piglet diarrhea of being taken medicine by sow Download PDFInfo
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Abstract
The present invention discloses a kind of Chinese medicine composition for prevention newborn piglet diarrhea of taking medicine by sow, and medicine group of the present invention becomes：27-43 parts of Angelica sinensis, 18-32 parts of safflower, 26-44 parts of Fructus Forsythiae, 24-36 parts of kelp, 23-37 parts of green peel, 28-44 parts of dried orange peel, 25-45 parts of the root bark of tree peony, 29-45 parts of rhizoma anemarrhenae, 16-24 parts of poria cocos, 21-35 parts of radix glycyrrhizae.The method of administration that the Chinese medicine composition of the present invention is taken medicine using newborn sow; achieve the purpose that to prevent newborn piglet diarrhea; and with stress small, time and labour saving, be adapted to the medication demand of Large-scale pig farm flow line production pattern prevention newborn piglet diarrhea, and can effectively prevent newborn piglet diarrhea caused by many reasons.
Description
Technical field
The present invention relates to a kind of veterinary drug, the Chinese medicine composition of particularly a kind of prevention newborn piglet diarrhea of being taken medicine by sow
And preparation method thereof.
Background technology
Newborn piglet diarrhea is a kind of multifactor property disease of generally existing under intensive pig production working condition, is had with row
The milky of special fishy odor or faint yellow loose stool are characterized.This disease infects soon, and incidence, lethality are high, and in whole
Nest is fallen ill, and even if the piglet of resistance to mistake, also growth and development is slow, easily forms cad pig, serious financial consequences are caused to pig production.
The disease occurs to breed and grow related with the excess of bacterium, virus or Enterozoa, it is also possible to nutritional imbalance
Caused by stimulate it is related, it is also possible to it is related with the increase of enteron aisle osmotic pressure.Recent studies have found that the characteristics of newborn piglet diarrhea, is
The piglet of the 1st week after birth often occurs for diarrhea, and antibiosis extract for treating is often undesirable, and is not associated with known pathogen.Closely
Over a little years, newborn piglet diarrhea, the prevalence in some areas and pig farm is on the rise, it has also become restricts the one of pig raising industry development
A key factor, serious threat the healthy sane development of pig breeding industry.
At present, clinically prevent newborn piglet diarrhea, mainly by improving feeding and management condition, using antibiotic and
The measures such as feeding technology are returned to reduce the generation of newborn piglet diarrhoeal diseases, piglet is mainly made a living with breast milk, and difficulty is administered orally, and
And oral administration increases labor intensity one by one, be not suitable for the medication demand of scale pasture pipeline system production model, at the same time
Intramuscular injection increases stress reaction again.Secondly, with the extensive use of antibiotic, particularly clinically Irrational Use of Drugs, cause
Make medicament residue and antibody-resistant bacterium serious all the more, the food-safety problem thus brought increasingly triggers the concern of the public.Although close
Reason returns the generation raised and can effectively control newborn piglet diarrhea, but the technology is more rambunctious, exists in actual production
Artificial to dissipate the drawbacks such as poison pollution environment, the rare outburst that may induce other latent diseases accidentally of biosafety control, makes
Into the loss of bigger.
The Chinese medicine composition of the disclosed treatment piglet severe diarrhea of Chinese invention patent application 2011102430301 be by：
1~11 part of radix scutellariae, 3~13 parts of Poria cocos, 3~13 parts of umbellate pore furgus, 1~9 part of rhizome of cyrtomium, 1~11 part of dried orange peel, 1~10 part of Chinese cassia tree.During use
It by each traditional Chinese medicinal components of the Chinese medicine composition is altogether smalls to be, directly gavages piglet.Chinese invention patent application 2012101401560
Disclose a kind of herb fermenting preparation and its manufacture method for preventing grice diarrhoea, the weight of its each component of the herb fermenting preparation
Number forms：10 parts of Herba Andrographitis, 8 parts of granatum, 8 parts of Fruticose Breyniae Leaf and Twig, 8 parts of purslane, 6 parts of kuh-seng, 10 parts of the Chinese bulbul, the coptis 10
Part；It is using being also to be taken directly to piglet.These obvious medicines equally exist piglet and directly take orally extremely difficult deficiency, and
It is completely unsuitable for newborn piglet.
Chinese invention patent application number：201110258204.1 disclose a kind of Chinese medicine for being used to prevent newborn piglet diarrhea
Composition, its medicine group become：16 parts of the Chinese bulbul, 8 parts of Herba Andrographitis, 8 parts of kuh-seng, 8 parts of radix scutellariae, 8 parts of Radix Isatidis, 10 parts of folium isatidis
6 parts of radix astragali, 4 parts of Radix Codonopsis, 6 parts of Cortex Phellodendri, 5 parts of Poria cocos, 6 parts of the bark of ash, 6 parts of myrobalan, 4 parts of Radix Paeoniae Alba, 4 parts of akebi, 4 parts of the banksia rose, radix glycyrrhizae 6
Part.There is clearing heat and detoxicating, antibacterial anti-inflammatory, tonifying middle-Jiao and Qi, invigorating the spleen to promote the production of body fluid for the patent application, tonifying Qi and lifting yang, dampness removing qi-regulating, promoting lactation and
Can be by various functions such as blood breast barriers, and be that piglet is treated by way of sow takes, overcome first skill
The foot of art not.Traditional veterinary science thinks that newborn piglet diarrhea occurs more because dam postpartum blood-head and postpartum blood stasis be not most.Because of milk
By blood institute metaplasia, dam blood-head, hemostasis is stagnated, then milk is unclear.Cub stomach is tender and lovely, and eupepsy is weak, and disease resistance is poor,
Breast milk is suck as crossed, stomach and intestine is injured, then influences digestion function of stomach and intestine, it is impossible to ascending the clear and descending the turbid, and diarrhea is sent out, but 201110258204.1
Patent application is with " clearing heat and detoxicating, antibacterial anti-inflammatory, invigorating the spleen are promoted the production of body fluid " for the main rules for the treatment of, it is impossible to inherently releases the mother of diseased piglet
Source property pathologic basis, therefore, though there is certain curative effect, is used to treating newborn piglet diarrhea that to fear curative effect slightly worse.
The content of the invention
The present invention provides one kind and can overcome the shortage of prior art, there is provided a kind of taken medicine by sow prevents newborn piglet diarrhea
Chinese medicine composition and preparation method thereof.
A kind of Chinese medicine composition by sow medication prevention newborn piglet diarrhea of the present invention is included in parts by weight
Following bulk pharmaceutical chemicals：27-43 parts of Angelica sinensis, 18-32 parts of safflower, 26-44 parts of Fructus Forsythiae, 24-36 parts of kelp, 23-37 parts of green peel, dried orange peel
28-44 parts, 25-45 parts of the root bark of tree peony, 29-45 parts of rhizoma anemarrhenae, 16-24 parts of poria cocos, 21-35 parts of radix glycyrrhizae.
The optimal prescription of Chinese medicine composition of the present invention is：35 parts of Angelica sinensis, 25 parts of safflower, 35 parts of Fructus Forsythiae, 30 parts of kelp, green peel
25 parts, 30 parts of dried orange peel, 35 parts of the root bark of tree peony, 37 parts of rhizoma anemarrhenae, 20 parts of poria cocos, 28 parts of radix glycyrrhizae.
A kind of Chinese medicine composition by sow medication prevention newborn piglet diarrhea of the present invention generally comprises aforementioned proportion
The traditional Chinese medicine ingredients and excipient of part, such as solid carrier, anticaking agent and flavouring, and can be according to conventional formulation side
Method, uses after the formulations such as powder, medicinal extract pulvis, granule are prepared into.
Example as the solid carrier of excipient includes lactose, sucrose, cornstarch, starch, cellulose derivative, algae
Acid etc..
Example as anticaking agent includes silica, microcrystalline cellulose, potassium ferrocyanide, sodium silicoaluminate, tricalcium phosphate
Deng.
Example as flavouring includes glycine, saccharin sodium, honey element, Aspartame etc..
Further, if it is desired, Chinese medicine composition of the present invention can contain conventional additives such as flavouring, and preferably adopt
With the rear use such as powder, pellet agent, soluble powder of conventional method system.This preparation of the Chinese medicine composition of the present invention is excellent
Choosing contains the traditional Chinese medicine ingredients of aforementioned proportion part of about 20%-100% by weight as active ingredient.
Chinese medicine composition of the present invention can be conventional traditional Chinese powder medicine form, its preparation method be in prescription ratio weigh it is each in
Medicine component, dries after net system, is stirred evenly after crushing, the Chinese medicine for the prevention newborn piglet diarrhea that obtains taking medicine by sow through packing
Composition.Currently preferred preparation method is：It is both easy using the drying of this temperature with 65 DEG C of drying and processings after net system processing
It is not easy to make its saccharification in crushing, while for the medicinal material high to some sugar contents, 100 ~ 200 mesh sieves is crossed after crushing, are obtained ultra-fine
Pulvis.
Chinese medicine composition of the present invention can also use Chinese medicinal compound extract medicinal extract pulvis, and its preparation method is in prescription ratio
Weigh each Chinese medicinal component, after net system removal of impurities, add the purified water of 8-10 times of medicinal material weight, decoct three times, every time 1 it is small when, considered,
Merging filtrate, it is 1.31 ~ 1.35 to use conventional method to concentrate as relative density to relative density（50~55℃）Thick paste, spraying
It dry, pulverize, add anticaking agent, the anti-Chinese medicine group drawn humectant etc., mix prevention newborn piglet diarrhea of taking medicine to obtain the final product by sow
Compound medicinal extract pulvis.
Chinese medicine composition of the present invention can be Chinese herbal granules form, and its preparation method is to weigh each Chinese medicine in prescription ratio
Component, net system removal of impurities after, add 8-10 times of medicinal material weight purified water, decoct three times, every time 1 it is small when, considered, merging filtrate,
It is 1.31 ~ 1.35 to use conventional method to concentrate as relative density to relative density（50~55℃）Thick paste, add appropriate amount of auxiliary materials, such as
Soluble starch, cane sugar powder, lactose etc., are made particle, dry, up to the Chinese medicine for prevention newborn piglet diarrhea of being taken medicine by sow
Composition granule.Advantages and advantages of the invention are as follows：1）The present invention is for newborn piglet diarrhea and its sow postpartum
Relation between the physiological pathology feature that blood stasis does not disappear, selects Angelica sinensis, safflower, Fructus Forsythiae, kelp, green peel, dried orange peel, the root bark of tree peony, rhizoma anemarrhenae, red Fu
The traditional Chinese medicine such as Siberian cocklebur and radix glycyrrhizae, by each medicine compatibility, the effect of reaching " promoting blood circulation and removing blood stasis, clearing away heat and promoting diuresis ", adjust the entirety of sow
Physiological function state, improves sow milk performance and milk quality, to strengthen piglet immunological phylactic power defensive power, restores piglet gastrointestinal system
Function, the purpose of Da Dao More diseases.2）Taken medicine by newborn sow and prevent newborn piglet diarrhea, stress be small, time and labour saving, is adapted to rule
The medication demand of newborn piglet diarrhea is prevented under the flow line production pattern of modelling pig farm.
Embodiment
Hereinafter, the present invention is explained in detail by providing preparation example and test example, but the present invention is not limited to this
A little embodiments.Below in an example, term " part " refers to parts by weight.
Preparation example 1.
A kind of preparation method for the Chinese medicine composition for preventing newborn piglet diarrhea of being taken medicine by sow, comprises the following steps：
In prescription ratio, 35 parts of Angelica sinensis, 25 parts of safflower, 35 parts of Fructus Forsythiae, 30 parts of kelp, 25 parts of green peel, 30 parts of dried orange peel, the root bark of tree peony 35 are weighed
Part, 37 parts of rhizoma anemarrhenae, 20 parts of poria cocos, 28 parts of radix glycyrrhizae, net system, 65 DEG C dry, and ultramicro grinding is crossed 150 mesh sieves, stirred evenly, point
Dress, up to the Chinese medicine composition for prevention newborn piglet diarrhea of being taken medicine by sow.
Preparation example 2.
A kind of preparation method for the Chinese medicine composition for preventing newborn piglet diarrhea of being taken medicine by sow, comprises the following steps：
In prescription ratio, 35 parts of Angelica sinensis, 25 parts of safflower, 35 parts of Fructus Forsythiae, 30 parts of kelp, 25 parts of green peel, 30 parts of dried orange peel, the root bark of tree peony 35 are weighed
Part, 37 parts of rhizoma anemarrhenae, 20 parts of poria cocos, 28 parts of radix glycyrrhizae, after net system removal of impurities, adds the purified water of 8-10 times of medicinal material weight, decocts three
It is secondary, every time 1 it is small when, considered, merging filtrate, it for relative density to relative density is 1.31 ~ 1.35 to use conventional method concentration（50
~55℃）Thick paste, be spray-dried, crush, add anticaking agent, it is anti-draw humectant etc., mix up to newborn by sow prevention of taking medicine
The Chinese medicine composition medicinal extract pulvis of grice diarrhoea.
Preparation example 3.
A kind of preparation method for the Chinese medicine composition for preventing newborn piglet diarrhea of being taken medicine by sow, comprises the following steps：
In prescription ratio, 43 parts of Angelica sinensis, 32 parts of safflower, 44 parts of Fructus Forsythiae, 36 parts of kelp, 37 parts of green peel, 44 parts of dried orange peel, the root bark of tree peony 45 are weighed
Part, 45 parts of rhizoma anemarrhenae, 24 parts of poria cocos, 35 parts of radix glycyrrhizae, after net system removal of impurities, adds the purified water of 8-10 times of medicinal material weight, decocts three
It is secondary, every time 1 it is small when, considered, merging filtrate, it for relative density to relative density is 1.31 ~ 1.35 to use conventional method concentration（50
~55℃）Thick paste, add appropriate amount of auxiliary materials, such as soluble starch, cane sugar powder, lactose, particle be made, it is dry, pass through sow to obtain the final product
The Chinese medicinal composition granules of medication prevention newborn piglet diarrhea.
Following test example proves beneficial prevention effect of the Chinese medicine composition for newborn piglet diarrhea of the present invention, to prepare
Example 1 is used as and supplies reagent thing.
1. Chinese medicine composition of the present invention of embodiment prevents the clinical experimental study of newborn piglet diarrhea
1. test site Lanzhou suburbs Large-scale pig farm, sow livestock on hand 200, before experiment, the production on the pig farm
There is the diarrhoeal diseases of unknown cause in room piglet, using conventional control measure（Such as improve delivery room management measure, antibiotic therapy and mouth
Take fluid infusion salt etc.）, without obvious effect.
2. experimental animal chooses parity, weight, age, litter size, 24 newborn sows similar in term, random point
It is respectively Chinese medicine composition group of the present invention and control group for 2 groups.The sow immunization program included is consistent, the gestational period and
Postpartum feeding and management condition is consistent, is the spacing raising in single column.
3. testing program
3.1 therapeutic schemes use mixed feeding oral administration, are selected in sow, and in postpartum, medicament is given with every 400 grams of part
Amount, this product is placed on wheat bran/feed in crib, after wheat bran wheat bran/feed is sprinkled on the medicine, allow sow to adopt completely
Food, is administered once a day, once every three days.
3.2 newborn piglet diarrhea diagnostic criteria：（1）Fecal character has change, and in atherosclerotic or watery diarrhea, color is yellowish-white, yellow
It is green or greyish white, or foul smelling；（2）Defecation frequency significantly increases；（3）Disease time 1-7 day；（4）With diseases such as abdominal distension, abdominal pain.Tool
It is standby（1）、（2）With（3）Symptom under, that is, be diagnosed as newborn piglet diarrhea.
3.3 observation index conscientiously observe and record situations such as piglet excrement, spirit, appetite, morbidity daily, and measure piglet
Average weigth at birth and 23 ages in days are averaged weight of weaning litter.Newborn piglet diarrhea case is made a definite diagnosis according to following diagnostic criteria.
4. data processing carries out data analysis using SPSSV17.0.Chi-square Test is evaluated cure rate between each group and is had
The otherness of efficiency, all statistical checks use two-sided test,P<0.05 thinks that the difference of inspection is statistically significant.
5. result and analysis
Chinese medicine composition of the present invention is shown in Table 1 by the effect of sow postpartum medication prevention newborn piglet diarrhea.With control group
Compare, the newborn piglet for suffering from diarrhea in Chinese medicine composition group of the present invention significantly reduces, and difference is extremely notable（P<0.01）；The present invention
Death and culling rate of the newborn piglet when turning group on 23rd in Chinese medicine composition is remarkably decreased, and difference is extremely notable（P<0.01）；Bring into
The birth counterpoise of piglet is suitable in two groups, no significant difference（P>0.05）, and during wean on the 23rd, Chinese medicine composition group of the present invention
In piglet average weight be higher than control group in piglet counterpoise, significant difference（P<0.05）.Show, Chinese medicine composition of the present invention
Piglet is averaged when being taken medicine by sow postpartum, can effectively prevent newborn piglet diarrhea, and being remarkably improved the wean of 23 ages in days
Weight.
The clinical experimental study of the traditional Chinese medicine composition for treating newborn piglet diarrhea of the present invention of embodiment 2.
1. test site Lanzhou suburbs Large-scale pig farm, sow livestock on hand about 200.
2. experimental animal chooses parity, weight, age, litter size, the close newborn sow of term, the day for the pig that farrows
Age, naturally-occurring diarrhea was demonstrate,proved in 1 ~ 7 day, and whole nest morbidity is presented.
3. newborn piglet diarrhea diagnostic criteria and curative effect determinate standard
3.1 diagnostic criteria（1）Fecal character has change, and in atherosclerotic or watery diarrhea, color is yellowish-white, yellowish green or greyish white, or has
Stench；（2）Defecation frequency significantly increases；（3）Disease time 1-7 day；（4）With diseases such as abdominal distension, abdominal pain.Possess（1）、（2）With（3）
Symptom under, that is, be diagnosed as newborn piglet diarrhea.
3.2 the standard of curative effect evaluation
Cure：Affected pig spirit, the extensive place of appetite are normal, and excrement is in bar shaped or graininess, and anus is dry, shrinks, without redness.
Effectively：Affected pig spirit, appetite make moderate progress, and excrement slightly thickens, and diarrhea number is reduced, and anus redness does not disappear.
It is invalid：Diarrhea disease has no mitigation or even aggravates, dead in therapeutic process.
3. therapeutic scheme and observation index
Selected 30 newborn sows are randomly divided into 2 groups, every group 15, the new breeder mother of Chinese medicine composition group of the present invention
Pig, with the dosage of every 400 grams of part, this product is placed on wheat bran/feed in crib, after sprinkle wheat bran on the medicine
Wheat bran/feed, allows sow free choice feeding, is administered once a day, depending on grice diarrhoea situation, medication 1-3 time；If diseased newborn piglet
Do not suck the breast, then the sow milk of Chinese medicine composition of the present invention is fed by human assistance.Control group is normal using the pig farm
Advise therapeutic scheme, newborn piglet：Norfloxacin oral liquid：5 below kg of weight 1 mL/ times, 5-10 kg weight 2 mL/ times, warp
Mouth gavages；Serious patient can take 1 time again after 6 h；Oral rehydration salts：After dissolving, give piglet 5-10mL.It is if it find that new
Breeder mother pig suffers from mammitis, then gives sow：20 mL/ heads of houttuynia cordata injection, ofloxacin injection：0.1–0.2 mL/
Kg, intramuscular injection, 1-2 time/d, is used in conjunction 2-3d.Situations such as conscientiously observing and recording piglet excrement, spirit, appetite, morbidity daily.
4. statistical analysis
Test data is analyzed with SPSS V17.0.The cure rate and total effective rate card side of test group and control group
（X 2 ）Examine comparative analysis.
5. result and analysis
Chinese medicine composition of the present invention is shown in Table 2 by the effect of sow postpartum medication treatment newborn piglet diarrhea.Two groups are compared,
Incidence no significant difference（P>0.05）, illustrate that two groups of baselines are comparable.Compared with the control group, Chinese medicine composition of the present invention
The cure rate and total effective rate for treating newborn piglet diarrheic syndromes are significantly increased, and difference is extremely notable（P<0.001）.Show this
Religious name Chinese medicine composition can effectively treat newborn piglet diarrhea by the medication of sow postpartum.
Conclusion：Above-described embodiment the result shows that, Chinese medicine composition of the present invention can effectively be treated new by the medication of sow postpartum
Newborn's diarrhea of pigs.
Finally it should be noted that：The foregoing is only a preferred embodiment of the present invention, is not intended to limit the invention,
Although the present invention is described in detail with reference to the foregoing embodiments, for those skilled in the art, it still may be used
To modify to the technical solution described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic.
Within the spirit and principles of the invention, any modification, equivalent replacement, improvement and so on, should be included in the present invention's
Within protection domain.
Claims (6)
- A kind of 1. Chinese medicine composition for prevention newborn piglet diarrhea of being taken medicine by sow, it is characterised in that：The Chinese medicine composition Following bulk pharmaceutical chemicals composition in parts by weight：27-43 parts of Angelica sinensis, 18-32 parts of safflower, 26-44 parts of Fructus Forsythiae, 24-36 parts of kelp, 23-37 parts of green peel, 28-44 parts of dried orange peel, 25-45 parts of the root bark of tree peony, 29-45 parts of rhizoma anemarrhenae, 16-24 parts of poria cocos, 21-35 parts of radix glycyrrhizae.
- 2. a kind of Chinese medicine composition of prevention newborn piglet diarrhea of being taken medicine by sow according to claim 1, its feature It is 35 parts of Angelica sinensis, 25 parts of safflower, 35 parts of Fructus Forsythiae, 30 parts of kelp, 25 parts of green peel, 30 parts of dried orange peel, 35 parts of the root bark of tree peony, 37 parts of rhizoma anemarrhenae, 20 parts of poria cocos, 28 parts of radix glycyrrhizae.
- 3. the system of any Chinese medicine composition for preventing newborn piglet diarrhea of being taken medicine by sow described in claim 1 or 2 Preparation Method, it is characterised in that weigh each traditional Chinese medicinal components in prescription ratio, dry after net system, stirred evenly after crushing, through dispensing To the Chinese medicine composition for prevention newborn piglet diarrhea of being taken medicine by sow.
- 4. preparation method according to claim 3, it is characterised in that 65 DEG C of drying and processings after net system, excessively 100 after crushing ~ 200 mesh sieves.
- 5. the preparation of any Chinese medicine composition for preventing newborn piglet diarrhea of being taken medicine by sow described in claim 1 or 2 Method, it is characterised in that：Each traditional Chinese medicinal components are weighed in prescription ratio, after net system removal of impurities, add the purifying of 8-10 times of medicinal material weight Water, decoct three times, every time 1 it is small when, filtration, merging filtrate, use conventional method concentration for 50 ~ 55 DEG C when relative density 1.31 ~ 1.35 thick paste, is spray-dried, crushing, adds anticaking agent, resists and draw humectant, mixes and prevent newborn piglet up to taking medicine by sow The Chinese medicine composition medicinal extract pulvis of diarrhea.
- 6. the preparation of any Chinese medicine composition for preventing newborn piglet diarrhea of being taken medicine by sow described in claim 1 or 2 Method, it is characterised in that：Each traditional Chinese medicinal components are weighed in prescription ratio, after net system removal of impurities, add the purifying of 8-10 times of medicinal material weight Water, decoct three times, every time 1 it is small when, filtration, merging filtrate, use conventional method concentration for 50 ~ 55 DEG C when relative density 1.31 ~ 1.35 thick paste, adds appropriate soluble starch, cane sugar powder, lactose, and particle is made, dry, up to new by sow medication prevention The Chinese medicinal composition granules of newborn's diarrhea of pigs.
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| CN106822890B (en) * | 2017-01-19 | 2021-06-04 | 中国农业科学院兰州畜牧与兽药研究所 | Pharmaceutical composition for preventing and treating diarrhea of weaned piglets and preparation method and application thereof |
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