CN102451265A - Effervescent traditional Chinese medicine composition for treating livestock constipation and preparation method thereof - Google Patents
Effervescent traditional Chinese medicine composition for treating livestock constipation and preparation method thereof Download PDFInfo
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- CN102451265A CN102451265A CN201010528242XA CN201010528242A CN102451265A CN 102451265 A CN102451265 A CN 102451265A CN 201010528242X A CN201010528242X A CN 201010528242XA CN 201010528242 A CN201010528242 A CN 201010528242A CN 102451265 A CN102451265 A CN 102451265A
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- effervescent
- constipation
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Abstract
The invention relates to an effervescent traditional Chinese medicine composition for treating livestock constipation. The traditional Chinese medicine composition comprises the following components in parts by weight: 40-60 parts of Chinese rhubarb, 20-50 parts of magnolia bark, 20-50 parts of citrus aurantium, 150-200 parts of natrii sulfas exsiccatus, 40-120 parts of effervescent agent and 20-60 parts of lubricant. The effervescent traditional Chinese medicine composition for treating livestock constipation provided by the invention has the advantages of convenience for use, lower cost, high action speed, no toxic or side effect, no medicament residue and high bioavailability, simplifies operation and saves breeding cost.
Description
Technical field
The invention belongs to domestic animal and use field of veterinary, especially a kind of effervescent Chinese medicinal composition of treating the domestic animal constipation and preparation method thereof.
Background technology
The domestic animal constipation is because food or Excreta become dry matter in intestinal tube; Stop and not all right, cause the intestinal tube peristaltic forces to weaken, finally cause Excreta to be blocked in internal rectum fully and can not normally discharge; The duty act of defecation often appears exerting in domestic animal; It is single that the constipation cause of disease is mainly the nutrition of feeding for a long time, or flip-flop some fibre and the coarse feedstuff of processing, or the thing of silt is arranged among the forage.Scale of feeding irregular, it is full to feed immediately after usage or the usage under these circumstances.More than several kinds etc. can both cause the intestinal digestive functional disturbance, cause intestinal tube injured, the body fluid consume, forage is difficult to digestion, large intestine conduction imbalance.Symptom: disease is first can arrange a small amount of feces, and the excrement ball is dried and hard, and has intestinal mucosa on excrement ball surface, discharges feces painstakingly thereupon, and it is black that the feces of discharge is done, it is thus clear that often there is the blood streak on the feces surface, the later stage defecation stops fully.It is the disease of cardinal symptom that domestic animal is taken place with combined symptoms, constipation, if take the treatment measure untimely, often causes young stock dead easily, becomes poultry to lose flesh, and weightening finish reduces, and Time To Market is postponed, and the domestic animal premunition descends, and causes enormous economic loss to the raiser.And ill domestic animal often stops to search for food when ill, and traditional companion expects that medication can't make the medicine focus of going directly, treatment time that has not only delayed but also cause unnecessary waste.
Summary of the invention
The object of the present invention is to provide a kind of effervescent Chinese medicinal composition of treating the domestic animal constipation, this Chinese medicine composition is easy to use, onset speed is fast, have no side effect and drug residue, simplifies the operation, and practices thrift aquaculture cost, and bioavailability is high.
Another object of the present invention is to provide a kind of method for preparing of treating the effervescent Chinese medicinal composition of domestic animal constipation.
The present invention realizes through following technical scheme:
A kind of effervescent Chinese medicinal composition of treating the domestic animal constipation, its Chinese medicinal composition and ratio of weight and number thereof are:
Radix Et Rhizoma Rhei 40-60 part;
Cortex Magnoliae Officinalis 20-50 part;
Fructus Aurantii Immaturus 20-50 part;
Matrii Sulfas Exsiccatus 150-200 part;
Effervescent 40-120 part;
Lubricant 20-60 part.
And described effervescent is made up of the wherein a kind of and sodium bicarbonate weight ratio in tartaric acid, citric acid or the adipic acid at 1: 1.
And described lubricant is sucralose, erythritol, magnesium stearate or dodecyl sodium sulfate.
A kind of method for preparing of treating the effervescent Chinese medicinal composition of domestic animal constipation, its step is following:
(1) take by weighing Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus according to weight proportion, pulverize and mix back decocte with water 3 times, 2 hours for the first time, the second time and each 1 hour for the third time; Merge decoction liquor, filter, filtrating is concentrated into relative density to be 1.20～1.25 and in the time of 78～82 ℃, to add the 2mol/L hydrochloric acid solution and regulate pH value to 1.0～2.0, is incubated 1 hour; Left standstill 11～13 hours, and filtered, obtain deposition, in deposition, add 6～8 times of water gagings; Form mixed liquor, with 40% sodium hydroxide solution adjust pH to 7.0, adding with the isopyknic concentration of mixed liquor is 90～95% alcoholic solution again, and stirring makes dissolving; Filter, filtrating is incubated 25～35 minutes with 2mol/L hydrochloric acid solution adjust pH to 2.0 down at 55～65 ℃, leaves standstill 10～14 hours; Filter, deposition is washed till pH value to 7.0 with ethanol, waves most ethanol, and it is subsequent use to obtain extract behind the concentrate drying;
(2) extract that takes by weighing in Matrii Sulfas Exsiccatus, effervescent, lubricant and the step (1) according to weight proportion is pulverized respectively, and the raw material of pulverizing respectively all through abundant mix homogeneously behind 80 mesh sieves, is obtained mixture A;
(3) be binding agent system soft material with mixture A with 50～60% alcoholic solution of 2～4%PVP; Soft material is all processed granule through 10～15 mesh sieves; Under 50～60 ℃, carry out aeration-drying; All process granulate then, the effervescent Chinese medicinal composition finished product of the domestic animal constipation that promptly obtains medical treatment through 20～30 mesh sieves.
Advantage of the present invention and beneficial effect are:
1. this effervescent Chinese medicinal composition adopts Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Furctus Aurantii Immaturus extract and Matrii Sulfas Exsiccatus as effective Chinese medicinal ingredients, has and well captures accumulation of heat, the effect of the logical intestinal of broken knot.As the natural Chinese medicines extract, do not have any poisonous and harmful substance simultaneously, can not produce toxic and side effects, more can not exert an influence health to animal body.
2. this effervescent Chinese medicinal composition is introduced the effervescent technology in the granulate preparation of this medicine into cleverly; Can make the dispensing treatment more handy; Save a large amount of manpower and materials, the effective ingredient in the medicine is dissolved rapidly and uniformly, be convenient to domestic animal and absorb; Improve bioavailability, can significantly improve the clinical efficacy of medicine.
Easy to use, the onset speed of the present invention fast, have no side effect and drug residue, simplify the operation, practice thrift aquaculture cost, be the effervescent Chinese medicinal composition of the high treatment domestic animal constipation of a kind of bioavailability.
The specific embodiment
The present invention further details through following examples.Need to prove: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Matrii Sulfas Exsiccatus, tartaric acid, citric acid, adipic acid, sodium bicarbonate, sucralose, erythritol, magnesium stearate and dodecyl sodium sulfate all can be bought on market and obtain in the component involved in the present invention.
Embodiment 1
A kind of effervescent Chinese medicinal composition of treating the domestic animal constipation, its Chinese medicinal composition and weight thereof are respectively Radix Et Rhizoma Rhei 40Kg, Cortex Magnoliae Officinalis 20Kg, Fructus Aurantii Immaturus 20kg, Matrii Sulfas Exsiccatus 150kg, effervescent 40Kg, lubricant 20Kg; Above-mentioned effervescent is made up of citric acid 20Kg and sodium bicarbonate 20Kg, and lubricant is a magnesium stearate.
A kind of method for preparing of treating the effervescent Chinese medicinal composition of domestic animal constipation, its step is following:
(1) take by weighing Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus according to weight proportion, pulverize and mix back decocte with water 3 times, 2 hours for the first time, the second time and each 1 hour for the third time; Merge decoction liquor, filter, filtrating is concentrated into relative density to be 1.20 and in the time of 78 ℃, to add the 2mol/L hydrochloric acid solution and regulate pH value to 1.0, is incubated 1 hour; Left standstill 11 hours, and filtered, obtain deposition, in deposition, add 6 times of water gagings; Form mixed liquor, with 40% sodium hydroxide solution adjust pH to 7.0, adding with the isopyknic concentration of mixed liquor is 90% alcoholic solution again, and stirring makes dissolving; Filter, filtrating is incubated 25 minutes with 2mol/L hydrochloric acid solution adjust pH to 2.0 down at 55 ℃, leaves standstill 10 hours; Filter, deposition is washed till pH value to 7.0 with ethanol, waves most ethanol, and it is subsequent use to obtain extract behind the concentrate drying;
(2) extract that takes by weighing in Matrii Sulfas Exsiccatus, effervescent, lubricant and the step (1) according to weight proportion is pulverized respectively, and the raw material of pulverizing respectively all through abundant mix homogeneously behind 80 mesh sieves, is obtained mixture A;
(3) be binding agent system soft material with mixture A with 50% alcoholic solution of 2%PVP; Soft material is all processed granule through 10 mesh sieves; Under 50 ℃, carry out aeration-drying, all process granulate then, the effervescent Chinese medicinal composition finished product of the domestic animal constipation that promptly obtains medical treatment through 20 mesh sieves.
Embodiment 2
A kind of effervescent Chinese medicinal composition of treating the domestic animal constipation, its Chinese medicinal composition and weight thereof are respectively Radix Et Rhizoma Rhei 60Kg, Cortex Magnoliae Officinalis 50Kg, Fructus Aurantii Immaturus 50kg, Matrii Sulfas Exsiccatus 200kg, effervescent 120Kg, lubricant 60Kg; Above-mentioned effervescent is made up of tartaric acid 60Kg and sodium bicarbonate 60Kg, and lubricant is a dodecyl sodium sulfate.
A kind of method for preparing of treating the effervescent Chinese medicinal composition of domestic animal constipation, its step is following:
(1) take by weighing Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus according to weight proportion, pulverize and mix back decocte with water 3 times, 2 hours for the first time, the second time and each 1 hour for the third time; Merge decoction liquor, filter, filtrating is concentrated into relative density to be 1.25 and in the time of 82 ℃, to add the 2mol/L hydrochloric acid solution and regulate pH value to 2.0, is incubated 1 hour; Left standstill 13 hours, and filtered, obtain deposition, in deposition, add 8 times of water gagings; Form mixed liquor, with 40% sodium hydroxide solution adjust pH to 7.0, adding with the isopyknic concentration of mixed liquor is 95% alcoholic solution again, and stirring makes dissolving; Filter, filtrating is incubated 35 minutes with 2mol/L hydrochloric acid solution adjust pH to 2.0 down at 65 ℃, leaves standstill 14 hours; Filter, deposition is washed till pH value to 7.0 with ethanol, waves most ethanol, and it is subsequent use to obtain extract behind the concentrate drying;
(2) extract that takes by weighing in Matrii Sulfas Exsiccatus, effervescent, lubricant and the step (1) according to weight proportion is pulverized respectively, and the raw material of pulverizing respectively all through abundant mix homogeneously behind 80 mesh sieves, is obtained mixture A;
(3) be binding agent system soft material with mixture A with 60% alcoholic solution of 4%PVP; Soft material is all processed granule through 15 mesh sieves; Under 60 ℃, carry out aeration-drying, all process granulate then, the effervescent Chinese medicinal composition finished product of the domestic animal constipation that promptly obtains medical treatment through 30 mesh sieves.
Embodiment 3
A kind of effervescent Chinese medicinal composition of treating the domestic animal constipation, its Chinese medicinal composition and weight thereof are respectively Radix Et Rhizoma Rhei 50Kg, Cortex Magnoliae Officinalis 30Kg, Fructus Aurantii Immaturus 30kg, Matrii Sulfas Exsiccatus 180kg, effervescent 60Kg, lubricant 20Kg; Above-mentioned effervescent is made up of adipic acid 30Kg and sodium bicarbonate 30Kg, and lubricant is a sucralose.
The step of its preparation method is with embodiment 1.
Embodiment 4
A kind of effervescent Chinese medicinal composition of treating the domestic animal constipation, its Chinese medicinal composition and weight thereof are respectively Radix Et Rhizoma Rhei 40Kg, Cortex Magnoliae Officinalis 50Kg, Fructus Aurantii Immaturus 50kg, Matrii Sulfas Exsiccatus 170kg, effervescent 100Kg, lubricant 30Kg; Wherein effervescent is made up of adipic acid 50Kg and sodium bicarbonate 50Kg, and lubricant is an erythritol.
The step of its preparation method is with embodiment 1.
Embodiment 5
A kind of effervescent Chinese medicinal composition of treating the domestic animal constipation, its Chinese medicinal composition and weight thereof are respectively Radix Et Rhizoma Rhei 60Kg, Cortex Magnoliae Officinalis 30Kg, Fructus Aurantii Immaturus 20kg, Matrii Sulfas Exsiccatus 160kg, effervescent 80Kg, lubricant 40Kg; Above-mentioned effervescent is made up of tartaric acid 40Kg and sodium bicarbonate 40Kg, and lubricant is a sucralose.
The step of its preparation method is with embodiment 1.
The present invention does not need dissolving in advance in application, directly drop into and culture in the domestic animal drinking water, and the per kilogram water body gets final product with this effervescent Chinese medicinal composition 1 gram-10 grams.
The clinical practice experiment
1, experimental technique
At the beginning of 2009, my company is that certain cultivation base of periphery, Tianjin provides free the ill domestic animal of Drug therapy, and follows the tracks of the statistics therapeutic outcome.The domestic animal that suffers from combined symptoms, constipation is adopted two cover therapeutic schemes and adds up respectively: one group is the treatment group with the present invention's dispensing treatment of drinking water; One group is adopted the common Chinese companion to expect to treat to be matched group.At every turn offer medicine 1.25 yuan of costs of 64 of wherein treatment group treatment ill domestic animals, average every ill domestic animal; 58 of treatment of control group ill domestic animals, 0.78 yuan of the cost of on average offeing medicine.
2, experimental result
Obtain the result through primary part observation record morbidity rehabilitation situation, therapeutic effect of the present invention is obvious, adopts treatment group cure rate of the present invention than the matched group that adopts common Chinese companion material and improves 35%.In conjunction with dispensing number of times and cure rate, the treatment cost reduces by 41%.With SPSS12.0 statistics software analysis, behind the administration 5d, treatment group and matched group cure rate significant difference (p＜0.05).
Claims (4)
1. effervescent Chinese medicinal composition of treating the domestic animal constipation, it is characterized in that: this Chinese medicinal composition and ratio of weight and number thereof are:
Radix Et Rhizoma Rhei 40-60 part;
Cortex Magnoliae Officinalis 20-50 part;
Fructus Aurantii Immaturus 20-50 part;
Matrii Sulfas Exsiccatus 150-200 part;
Effervescent 40-120 part;
Lubricant 20-60 part.
2. the effervescent Chinese medicinal composition of treatment domestic animal according to claim 1 constipation, it is characterized in that: described effervescent is made up of the wherein a kind of and sodium bicarbonate weight ratio in tartaric acid, citric acid or the adipic acid at 1: 1.
3. the effervescent Chinese medicinal composition of treatment domestic animal according to claim 1 constipation, it is characterized in that: described lubricant is sucralose, erythritol, magnesium stearate or dodecyl sodium sulfate.
4. the method for preparing of the effervescent Chinese medicinal composition of treatment as claimed in claim 1 domestic animal constipation, it is characterized in that: the step of this method for preparing is following:
(1) take by weighing Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus according to weight proportion, pulverize and mix back decocte with water 3 times, 2 hours for the first time, the second time and each 1 hour for the third time; Merge decoction liquor, filter, filtrating is concentrated into relative density to be 1.20～1.25 and in the time of 78～82 ℃, to add the 2mol/L hydrochloric acid solution and regulate pH value to 1.0～2.0, is incubated 1 hour; Left standstill 11～13 hours, and filtered, obtain deposition, in deposition, add 6～8 times of water gagings; Form mixed liquor, with 40% sodium hydroxide solution adjust pH to 7.0, adding with the isopyknic concentration of mixed liquor is 90～95% alcoholic solution again, and stirring makes dissolving; Filter, filtrating is incubated 25～35 minutes with 2mol/L hydrochloric acid solution adjust pH to 2.0 down at 55～65 ℃, leaves standstill 10～14 hours; Filter, deposition is washed till pH value to 7.0 with ethanol, waves most ethanol, and it is subsequent use to obtain extract behind the concentrate drying;
(2) extract that takes by weighing in Matrii Sulfas Exsiccatus, effervescent, lubricant and the step (1) according to weight proportion is pulverized respectively, and the raw material of pulverizing respectively all through abundant mix homogeneously behind 80 mesh sieves, is obtained mixture A;
(3) be binding agent system soft material with mixture A with 50～60% alcoholic solution of 2～4%PVP; Soft material is all processed granule through 10～15 mesh sieves; Under 50～60 ℃, carry out aeration-drying; All process granulate then, the effervescent Chinese medicinal composition finished product of the domestic animal constipation that promptly obtains medical treatment through 20～30 mesh sieves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010528242XA CN102451265A (en) | 2010-11-02 | 2010-11-02 | Effervescent traditional Chinese medicine composition for treating livestock constipation and preparation method thereof |
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| CN201010528242XA CN102451265A (en) | 2010-11-02 | 2010-11-02 | Effervescent traditional Chinese medicine composition for treating livestock constipation and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104814301A (en) * | 2015-05-07 | 2015-08-05 | 杨帆 | Formula of feed specially used for cattle and sheep |
| CN106619939A (en) * | 2017-01-25 | 2017-05-10 | 杨鹏彪 | Traditional Chinese medicine preparation for treating constipation |
-
2010
- 2010-11-02 CN CN201010528242XA patent/CN102451265A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 张兆旺主编: "《中药药剂学第二版》", 31 March 2007, 中国中医药出版社 * |
| 李宁: "口服中药清洁肠道", 《中国实用护理杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104814301A (en) * | 2015-05-07 | 2015-08-05 | 杨帆 | Formula of feed specially used for cattle and sheep |
| CN106619939A (en) * | 2017-01-25 | 2017-05-10 | 杨鹏彪 | Traditional Chinese medicine preparation for treating constipation |
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Application publication date: 20120516 |