CN102641457B - Veterinary medicine compound preparation for treating coccidiosis, preparation method of veterinary medicine compound preparation and application - Google Patents
Veterinary medicine compound preparation for treating coccidiosis, preparation method of veterinary medicine compound preparation and application Download PDFInfo
- Publication number
- CN102641457B CN102641457B CN 201210129662 CN201210129662A CN102641457B CN 102641457 B CN102641457 B CN 102641457B CN 201210129662 CN201210129662 CN 201210129662 CN 201210129662 A CN201210129662 A CN 201210129662A CN 102641457 B CN102641457 B CN 102641457B
- Authority
- CN
- China
- Prior art keywords
- radix
- sophorae flavescentis
- coccidiosis
- preparation
- compound preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a veterinary medicine compound preparation for treating coccidiosis, a preparation method of the veterinary medicine compound preparation and application. The veterinary medicine compound preparation mainly consists of radix stemonae, radix sophorae flavescentis, solidago virgaurea and ethylenediamine diaceturate in a compatibility manner, is used for treating the coccidiosis, and is obvious in curative effect and not easy to cause tolerance. Raw materials are easy to be obtained. The invention further provides the preparation and the preparation method thereof. The veterinary medicine compound preparation can be prepared into granules, powder, premix, oral liquid and the like.
Description
Technical field
The present invention relates to a kind of compound preparation for the treatment of coccidiosis and preparation method thereof, belong to the veterinary drug technical field.
Background technology
Coccidiosis is one of disease of global popular serious harm livestock and poultry breeding industry, and primary disease distributes wide, and infection rate is high.Be accompanied by the development of aquaculture, the morbidity of coccidiosis has not had seasonality, and chicken group's coccidium infection rate is more than 80%, and the infection of duck goose also increases increasingly.Cause after the infection chicken large quantities of morbidities and dead, hinder growth promoter, the price of deed reduces, endanger very serious so that aquaculture cost improves greatly.According to investigations, the loss that causes because of coccidiosis every year of the whole world reaches 1,500,000,000 dollars.
At present, prevention and treatment coccidiosis, chemicals is still in occupation of leading position.But in the process of constantly medication, polypide has produced drug resistance, can only continue to increase dosage in order effectively to treat coccidiosis.In recent years, more and more higher to the prescription of Fowl meat along with the raising of people's living standard, country requires also more and more stricter for the food drug residue, therefore, is difficult for producing drug resistance and the low treatment coccidiosis medicine of drug residue and demands urgently developing.
CN1589847A (CN03150699.2) discloses a kind of compound Chinese medicinal preparation of preventing and treating coccidiosis, it is comprised of main active material and auxiliary activity component substances, through pulverize, mix or with the useable solvents extraction, concentrated, dry, pulverize and be prepared into preparation.The main active material is: Radix Dichroae, Herba Artemisiae Annuae, the Radix Pulsatillae; The auxiliary activity component substances is: Herba Verbenae, Herba Portulacae, Herba Artemisiae Scopariae, Herba Pteridis Multifidae, Herba Chenopodii Hybridi.The weight ratio of main active material is 50～70%, and the weight ratio of auxiliary activity component substances is 30～0%, and it mixes pre-mixing agent capable of using as feed with adjuvant; Molten water can be used as drinking agent.The present invention had had both prevented and treated coccidiosis, was difficult for again producing left drug in drug resistance and the body, compared with prior art can reduce by 50% cost.CN102319309A (CN201110228538.4) provides a kind of Chinese medicine preparation for the treatment of chicken coccidiosis, formed by Radix Dichroae, Herba Artemisiae Annuae, Radix Bupleuri, the Radix Pulsatillae, Ramulus Uncariae Cum Uncis, Herba Agrimoniae, Radix Sanguisorbae assembly, its preparation method comprises gets the raw materials ready, extracts, concentrates, adds starch, drying, pulverizing.It is Powdered that patent medicine is dark yellow in appearance, granularity and bulk density are even, make an addition to the feedstuff adhesiveness strong, feedstuff dyeing variable color is coordinated and can not made to color and luster, have that parasite killing protects the liver, the effect of cooling blood for hemostasis, dampness-eliminating and dysentery-stopping, heat-clearing and toxic substances removing, the mixed infection that is adapted to treat chicken coccidiosis and coccidiosis and antibacterial.
The characteristics such as the active component of Chinese herbal medicine is abundant, treating both the principal and secondary aspects of a disease, difficult generation drug resistance make it have good researching value and development space.But all there is toxicity in the main insecticidal constituent of pure compound Chinese medicinal preparation of existing treatment coccidiosis, such as Radix Dichroae, Fructus Bruceae, the Radix Pulsatillae etc., in case excessive use will produce toxic and side effects, even causes death.Therefore, its toxicity has limited its clinical use.
Summary of the invention
For the deficiencies in the prior art, the invention provides a kind of veterinary drug compound preparation for the treatment of coccidiosis and preparation method thereof and application.
Technical scheme of the present invention is as follows:
A kind of veterinary drug compound preparation for the treatment of coccidiosis, mainly made by the raw material of following weight portion:
Radix Stemonae 10-100 part, Radix Sophorae Flavescentis 10-100 part, Herba Solidaginis 10-100 part,
Ethyl Enediamine Diaceturate: be 0.1～5% of the Radix Stemonae, Radix Sophorae Flavescentis and Herba Solidaginis gross weight.
By existing pharmaceutically acceptable technique, this compound preparation can be made into the dosage forms such as oral liquid, granule, pulvis, pre-mixing agent, to make things convenient for the poultry administration.
Preferred according to the present invention, the veterinary drug compound preparation for the treatment of coccidiosis, the parts by weight of raw materials proportioning is as follows:
Radix Stemonae 10-50 part, Radix Sophorae Flavescentis 10-50 part, Herba Solidaginis 10-50 part, Ethyl Enediamine Diaceturate: be 0.3～1% of the Radix Stemonae, Radix Sophorae Flavescentis and Herba Solidaginis gross weight.
Further preferred according to the present invention, the veterinary drug compound preparation for the treatment of coccidiosis, proportioning raw materials is as follows: Radix Stemonae 30g, Radix Sophorae Flavescentis 20g, Herba Solidaginis 10g, Ethyl Enediamine Diaceturate 0.5g.
The present invention is the Chinese medicine and western medicine compound preparation, take the Radix Stemonae as monarch drug, and parasite killing; Radix Sophorae Flavescentis and Herba Solidaginis are ministerial drug, the heat clearing away sterilization; Ethyl Enediamine Diaceturate is adjuvant drug, for reducing intestinal capillary permeability, quick-acting haemostatic powder.
One of according to the present invention, the preparation method of the veterinary drug compound preparation of described treatment coccidiosis, preferred following:
A. the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis, Ethyl Enediamine Diaceturate are carried out respectively micronizing, cross 600 mesh sieves, by the proportioning mixing, packing namely gets pulvis.
B. get the Radix Stemonae, Radix Sophorae Flavescentis, the Herba Solidaginis 20～30h that is soaked in water by proportioning, 70～80 ℃ of heating and refluxing extraction 5～6 hours are filtered, filtrate decompression concentrated the extract extractum of 1.3～1.5g/mL, add Ethyl Enediamine Diaceturate by proportioning, stir, then adding granulates uses the adjuvant glucose, integrates and granulates, reduced vacuum is dry, after the sieve granulate, packing namely gets compound recipe QIUJING granule.
C. the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis were pulverized 80 mesh sieves, claim the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis to mix by proportioning, add the Radix Stemonae, Radix Sophorae Flavescentis and Herba Solidaginis gross weight 7-10 water doubly, soak 18-24h, 70～80 ℃ heating and refluxing extraction 5-6 hour, filter, in filtrate, add Ethyl Enediamine Diaceturate by proportioning, stir and make its dissolving, cooling, packing namely gets compound recipe QIUJING oral liquid.
In the preparation process of different dosage form, or have pharmaceutically acceptable adjuvant to add, its dosage bacterium is by the ability prior art, and these belong to well-known to those skilled in the art.
The application of the veterinary drug compound preparation for the treatment of coccidiosis of the present invention is used for control fowl poultry coccidiosis, and using method is as follows:
Pulvis and pre-mixing agent adopt the mixed feeding administration, and every 1kg feedstuff adds this product 10-20g; Granule and oral liquid adopt the administration of mixed drink, add this product 10-20g in every 1kg drinking-water.
How toxic insecticidal constituent is in the Chinese medicine preparation of prior art treatment coccidiosis, such as Radix Dichroae, Fructus Bruceae, the Radix Pulsatillae etc., limited its practical application.And the veterinary drug compound preparation property of medicine for the treatment of coccidiosis of the present invention is moderate, does not have toxic and side effects.And adopt the Chinese and Western combination, Ethyl Enediamine Diaceturate (ethylenediamine diaceturate) can quick-acting haemostatic powder, reduces poultry and infects behind the coccidiosis mortality rate because of severe loss of blood.
Chinese medicine of the present invention and chemical medicine composition of prescription can reduce the generation of chemical medicine drug resistance, and certain potentiation is arranged.Prescription of the present invention,, is difficult for producing drug resistance in conjunction with practice on the basis of effective parasite killing from coccidiosis Chinese veterinarian theory, and drug residue is low, and suppresses the generation of complication, the effect of performance treating both the principal and secondary aspects of a disease.Each component material is easy to get, and production technology is simple, convenient drug administration, greatly reduces production cost.
The specific embodiment
The present invention will be further described below in conjunction with embodiment, but be not limited to this.
Embodiment 1: pulvis
Get Radix Stemonae 30g, Radix Sophorae Flavescentis 20g, Herba Solidaginis 10g, Ethyl Enediamine Diaceturate 0.5g and carry out jet mill and pulverize, cross 600 mesh sieves after pulverizing, mixing, packing namely gets the pulvis of the veterinary drug compound preparation for the treatment of coccidiosis.
This product adds in the feedstuff, feeds for the fowl poultry that infects coccidiosis.Every 1kg feedstuff adds this product 15～20g.
Embodiment 2: granule
Radix Stemonae 60kg, Radix Sophorae Flavescentis 40kg and Herba Solidaginis 20kg are soaked in water behind the 24h, and amount of water not to be having raw material to be advisable, 80 ℃ of heating and refluxing extraction 6 hours, filter, filtrate decompression is concentrated into the extract extractum of 1.3～1.5g/mL, adds the Ethyl Enediamine Diaceturate of 0.5kg, stirs and makes dissolving, then add glucose, integrate and granulate, reduced vacuum is dry, after the sieve granulate, packing namely gets the granule of veterinary drug compound preparation for the treatment of coccidiosis.
Embodiment 3: oral liquid
With behind the water soaking 24h of 1125kg, 80 ℃ of heating and refluxing extraction 6 hours are filtered with Radix Stemonae 80kg, Radix Sophorae Flavescentis 55kg, Herba Solidaginis 25kg, get filtrate, add the Ethyl Enediamine Diaceturate of 500g, stir and make dissolving, cooling, packing namely gets the oral liquid of veterinary drug compound preparation for the treatment of coccidiosis.
Chicken farm effect experiment
From Shandong six and group plant chicken house and purchase 100 of the assorted chickens of 1 age in days meat, raise in the hen house of strict sterilization, feed with the standard compliant feedstuff that does not contain coccidiostat of autogamy, freely drink water.When brooding to 16 age in days, at random 100 chickling are divided into 5 groups, 20 every group for examination.
Test grouping and administration: totally 5 groups of tests, the blank group does not infect not administration; Infect the matched group not administration of falling ill; For 1 group of compound recipe pulvis that adopts embodiment 1 of examination, the mixed feeding administration, every 1kg feedstuff adds this product 15g; For examination 2 groups of diclazurils (available from Changzhou intelligent animals company limited), the administration of mixed drink, every 1L water adds this product 1mg; Adopt Maduramicin pre-mixing agent (available from the abundant Biology Pharmacy Co., Ltd of Zhejiang health) for 3 groups of examinations, per 1 kilogram of feed is added 10mg, mixed feeding administration; Except blank group and infection matched group, all the other are respectively organized in 18 ages in days and begin administration, are used in conjunction 7.
Test is with coccidian oocyst and infection method: test is provided by Shandong agricultural university animal medicine parasitic disease laboratory with the tender ear 1 coccidiosis Sporulated Oocysts of liking to be beautiful, and after toxicity test, presses 10 * 10
4Individual/only contamination.Except the blank group, during 20 age in days, to the artificial oral vaccination contamination of chicken.
Process of the test: after the contamination of 20 ages in days, Continuous Observation 7 days, record chicken spirit, appetite, feces situation.During 28 age in days, all cut open and kill, observe caecum lesion, calculate the egg sac number (OPG) of cecal content with the Maxwell method, calculate the egg capsule value by field, angle therapy for clearing away heat.Estimate according to indexs such as survival rate, rate of body weight gain, pathological changes value, anticoccidial index (ACI), egg capsule values and respectively to organize curative effect of medication.The results are shown in Table 1:
Table 1, anticoccidial experimental result
| Group | The chicken number | Survival rate % | Rate of body weight gain % | The pathological changes value | The egg capsule value | ACI |
| The blank group | 20 | 100.00 | 100.00 | 0.0 | 0 | 200.00 |
| Infect matched group | 20 | 75 | 57.14 | 39.56 | 12 | 80.58 |
| For 1 group of examination | 20 | 100.00 | 92.85 | 3.5 | 0 | 189.35 |
| For 2 groups of examinations | 20 | 95 | 85.71 | 4.0 | 1 | 175.71 |
| For 3 groups of examinations | 20 | 90 | 84.87 | 7.5 | 1 | 166.37 |
Evidence, product anticoccidial index of the present invention (ACI) is greater than 180, and is obvious to the chicken coccidiosis curative effect, and therapeutic effect is better than solution of diclazuril and Maduramicin pre-mixing agent.
Claims (5)
1. a veterinary drug compound preparation for the treatment of coccidiosis is characterized in that, is made by the raw material of following weight portion:
The Radix Stemonae: 10-100 part, Radix Sophorae Flavescentis: 10-100 part, Herba Solidaginis: 10-100 part,
Ethyl Enediamine Diaceturate: be 0.5～5% of the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis gross weight.
2. the veterinary drug compound preparation for the treatment of coccidiosis as claimed in claim 1 is characterized in that, the parts by weight of raw materials proportioning is as follows:
Radix Stemonae 10-50 part, Radix Sophorae Flavescentis 10-50 part, Herba Solidaginis 10-50 part, Ethyl Enediamine Diaceturate is 0.5～1% of the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis gross weight.
3. the veterinary drug compound preparation for the treatment of coccidiosis as claimed in claim 1 is characterized in that, proportioning raw materials is as follows: Radix Stemonae 30g, Radix Sophorae Flavescentis 20g, Herba Solidaginis 10g, Ethyl Enediamine Diaceturate 1g.
4. such as the veterinary drug compound preparation of each described treatment coccidiosis of claim 1～3, it is characterized in that, this compound preparation is made oral liquid, granule, pulvis, pre-mixing agent.
5. such as preparation method of the veterinary drug compound preparation of each described treatment coccidiosis of claim 1～4, step is one of following:
A. the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis, Ethyl Enediamine Diaceturate are carried out respectively micronizing, cross 600 mesh sieves, by the proportioning mixing, packing namely gets pulvis;
B. get the Radix Stemonae, Radix Sophorae Flavescentis, the Herba Solidaginis 20～30h that is soaked in water by proportioning, 70～80 ℃ of heating and refluxing extraction 5～6 hours are filtered, filtrate decompression concentrated the extract extractum of 1.3～1.5g/mL, add Ethyl Enediamine Diaceturate by proportioning, stir, then adding granulates uses the adjuvant glucose, integrates and granulates, reduced vacuum is dry, after the sieve granulate, packing namely gets compound recipe QIUJING granule;
C. the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis were pulverized 80 mesh sieves, claim the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis to mix by proportioning, add the Radix Stemonae, Radix Sophorae Flavescentis and Herba Solidaginis gross weight 7-10 water doubly, soak 18-24h, 70～80 ℃ heating and refluxing extraction 5-6 hour, filter, add Ethyl Enediamine Diaceturate by proportioning, stir and make its dissolving, cooling, packing namely gets compound recipe QIUJING oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210129662 CN102641457B (en) | 2012-04-27 | 2012-04-27 | Veterinary medicine compound preparation for treating coccidiosis, preparation method of veterinary medicine compound preparation and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210129662 CN102641457B (en) | 2012-04-27 | 2012-04-27 | Veterinary medicine compound preparation for treating coccidiosis, preparation method of veterinary medicine compound preparation and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102641457A CN102641457A (en) | 2012-08-22 |
| CN102641457B true CN102641457B (en) | 2013-10-16 |
Family
ID=46654700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210129662 Expired - Fee Related CN102641457B (en) | 2012-04-27 | 2012-04-27 | Veterinary medicine compound preparation for treating coccidiosis, preparation method of veterinary medicine compound preparation and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102641457B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103012187B (en) * | 2013-01-10 | 2014-08-20 | 黄明芳 | Novel diacetyl acetic acid quadrol compound and drug combination thereof |
| CN105396033B (en) * | 2015-11-30 | 2019-03-05 | 河南大德广动物药业有限公司 | A kind of Chinese medicine preparation and preparation method thereof for treating poultry globidiosis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085076B (en) * | 2007-06-22 | 2010-04-21 | 浙江省农业科学院 | Chinese and Western medicine united sustained-release injection for preventing and controlling coccidiosis of rabbit and its preparation method |
| CN101632815A (en) * | 2008-07-25 | 2010-01-27 | 天津中敖生物科技有限公司 | Common threewingnut root-containing Chinese medicinal composition for preventing and controlling parasites in aquaculture and preparation method thereof |
-
2012
- 2012-04-27 CN CN 201210129662 patent/CN102641457B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102641457A (en) | 2012-08-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103340287B (en) | Pannage | |
| CN103006792B (en) | A kind of herbal medicine for preventing and treating livestock and poultry intestinal canal diseases and preparation method thereof and feed | |
| CN102940155B (en) | Duckling feed for cherry valley duck and preparation method thereof | |
| CN101698024B (en) | Traditional Chinese medicine for treating respiratory diseases and promoting growth for swine and preparation method thereof | |
| CN101829211B (en) | Fish compound traditional Chinese medicinal preparation and preparation method thereof | |
| CN102885201B (en) | Compound Chinese herbal medicine feed additive | |
| CN102091151B (en) | Traditional medicinal composition with wind-dispelling and dampness-removing function and preparation method thereof | |
| CN102048785B (en) | Application of eupatorium adenophorum spreng in preparation of veterinary medicine or feed additive | |
| CN102641457B (en) | Veterinary medicine compound preparation for treating coccidiosis, preparation method of veterinary medicine compound preparation and application | |
| CN101209296A (en) | Chinese medicinal granule with worm-expelling liver-caring, hemostasis and dysentery-stopping efficacy | |
| CN105106495A (en) | Medicine for preventing and treating enteritis of fishes | |
| CN103285255B (en) | Anti-coccidiosis pharmaceutical composition as well as preparation method and use thereof | |
| CN102641354B (en) | Veterinary compound pure traditional Chinese medicine preparation for treating coccidium and preparing method and application thereof | |
| CN101244164A (en) | Medicament for preventing and treating hydropsy of pigling | |
| CN104825700A (en) | Traditional Chinese medicine composition for resisting bacteria and diminishing inflammation | |
| CN105106269A (en) | Traditional Chinese veterinary medicine for treating livestock and poultry bacterial diarrhea, preparation method and application thereof | |
| CN102805772A (en) | Application of coptis chinensis, amur cork-tree bark, Chinese rhubarb and skullcap dysentery inhibiting particles to preparation of medicines for treating intestinal diseases of poultry, and medicinal composition formed by compounding particles | |
| CN102266438B (en) | Antiviral agent for freshwater fishes | |
| CN101953962B (en) | Chinese traditional medicine and granular preparation for treating cestodosis and preparation method thereof | |
| CN107789394B (en) | Composition for treating livestock and poultry diarrhea | |
| CN104758390A (en) | Botanical drug compound preparation for preventing and treating porcine diarrhea and preparation method thereof | |
| CN102293867B (en) | Compound stellera chamae jasme linn. preparation for animals, and preparation method thereof | |
| CN102451265A (en) | Effervescent traditional Chinese medicine composition for treating livestock constipation and preparation method thereof | |
| CN105687508A (en) | Medicinal composition for preventing and treating crucian enteritis | |
| CN104873621A (en) | Antibacterial and anti-inflammation traditional Chinese medicine composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131016 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |