CN102641457A - Veterinary medicine compound preparation for treating coccidiosis, preparation method of veterinary medicine compound preparation and application - Google Patents
Veterinary medicine compound preparation for treating coccidiosis, preparation method of veterinary medicine compound preparation and application Download PDFInfo
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- CN102641457A CN102641457A CN201210129662XA CN201210129662A CN102641457A CN 102641457 A CN102641457 A CN 102641457A CN 201210129662X A CN201210129662X A CN 201210129662XA CN 201210129662 A CN201210129662 A CN 201210129662A CN 102641457 A CN102641457 A CN 102641457A
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- sophorae flavescentis
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Abstract
The invention relates to a veterinary medicine compound preparation for treating coccidiosis, a preparation method of the veterinary medicine compound preparation and application. The veterinary medicine compound preparation mainly consists of radix stemonae, radix sophorae flavescentis, solidago virgaurea and ethylenediamine diaceturate in a compatibility manner, is used for treating the coccidiosis, and is obvious in curative effect and not easy to cause tolerance. Raw materials are easy to be obtained. The invention further provides the preparation and the preparation method thereof. The veterinary medicine compound preparation can be prepared into granules, powder, premix, oral liquid and the like.
Description
Technical field
The present invention relates to a kind of compound preparation of treating coccidiosis and preparation method thereof, belong to the veterinary drug technical field.
Background technology
Coccidiosis is one of disease of global popular serious harm livestock and poultry breeding industry, and primary disease distributes wide, and infection rate is high.Be accompanied by the continuous development of aquaculture, the morbidity of coccidiosis has not had seasonality, and chicken crowd's coccidium infection rate is more than 80%, and the infection of duck goose also increases day by day.The large quantities of morbidities that cause chicken after the infection reduce with dead, obstruction growth promoter, the price of deed, and harm is very serious, makes aquaculture cost improve greatly.According to investigations, whole world every year because of coccidiosis cause with a toll of 1,500,000,000 dollars.
At present, prevention and treatment coccidiosis, chemicals is still in occupation of leading position.But in the process of constantly medication, polypide has produced drug resistance, can only continue to increase dosage in order effectively to treat coccidiosis.In recent years, the Along with people's growth in the living standard, increasingly high to the prescription of Fowl meat, country requires also more and more stricter for the food drug residue, therefore, be difficult for generation drug resistance and the low treatment coccidiosis medicine of drug residue and demand exploitation urgently.
CN1589847A (CN03150699.2) discloses a kind of compound Chinese medicinal preparation of preventing and treating coccidiosis; It is made up of main active material and auxiliary activity component substances, through pulverize, mix or with the useable solvents extraction, concentrate, dry, pulverize and be prepared into preparation.The main active material is: Radix Dichroae, Herba Artemisiae Annuae, the Radix Pulsatillae; The auxiliary activity component substances is: Herba Verbenae, Herba Portulacae, Herba Artemisiae Scopariae, Herba Pteridis Multifidae, Herba Chenopodii Hybridi.The weight ratio of main active material is 50～70%, and the weight ratio of auxiliary activity component substances is 30～0%, and it mixes pre-mixing agent capable of using as feed with adjuvant; Molten water can be used as drinking agent.The present invention had had both prevented and treated coccidiosis, was difficult for again producing left drug in drug resistance and the body, compared with prior art can reduce by 50% cost.CN102319309A (CN201110228538.4) provides a kind of Chinese medicine preparation of treating chicken coccidiosis; Formed by Radix Dichroae, Herba Artemisiae Annuae, Radix Bupleuri, the Radix Pulsatillae, Ramulus Uncariae Cum Uncis, Herba Agrimoniae, Radix Sanguisorbae assembly, its preparation method comprises gets the raw materials ready, extracts, concentrates, adds starch, drying, pulverizing.It is Powdered that patent medicine is dark yellow in appearance; Granularity and bulk density are even; It is strong to make an addition to the feedstuff adhesiveness; Color and luster is coordinated and can not made feedstuff dyeing variable color, has that parasite killing protects the liver, an effect of cooling blood for hemostasis, dampness-eliminating and dysentery-stopping, heat-clearing and toxic substances removing, the mixed infection that is adapted to treat chicken coccidiosis and coccidiosis and antibacterial.
Characteristics such as the active component of Chinese herbal medicine is abundant, treating both the principal and secondary aspects of a disease, difficult generation drug resistance make it have excellent research and are worth and development space.But all there is toxicity in the main insecticidal constituent of pure compound Chinese medicinal preparation of existing treatment coccidiosis, like Radix Dichroae, Fructus Bruceae, the Radix Pulsatillae etc., in case excessive use will produce toxic and side effects, even causes death.Therefore, its toxicity has limited its clinical use.
Summary of the invention
To the deficiency of prior art, the invention provides a kind of veterinary drug compound preparation of treating coccidiosis and preparation method thereof and application.
Technical scheme of the present invention is following:
A kind of veterinary drug compound preparation of treating coccidiosis, mainly process by the raw material of following weight portion:
Radix Stemonae 10-100 part, Radix Sophorae Flavescentis 10-100 part, Herba Solidaginis 10-100 part,
Diacetyl nitrilo acetic acid ethylenediamine: be 0.1～5% of the Radix Stemonae, Radix Sophorae Flavescentis and Herba Solidaginis gross weight.
By existing pharmaceutically acceptable technology, this compound preparation can be made into dosage forms such as oral liquid, granule, pulvis, pre-mixing agent, to make things convenient for the poultry administration.
Preferred according to the present invention, the veterinary drug compound preparation of treatment coccidiosis, the parts by weight of raw materials proportioning is following:
Radix Stemonae 10-50 part, Radix Sophorae Flavescentis 10-50 part, Herba Solidaginis 10-50 part, diacetyl nitrilo acetic acid ethylenediamine: be 0.3～1% of the Radix Stemonae, Radix Sophorae Flavescentis and Herba Solidaginis gross weight.
Further preferred according to the present invention, the veterinary drug compound preparation of treatment coccidiosis, proportioning raw materials is following: Radix Stemonae 30g, Radix Sophorae Flavescentis 20g, Herba Solidaginis 10g, diacetyl nitrilo acetic acid ethylenediamine 0.5g.
The present invention is the Chinese medicine and western medicine compound preparation, is monarch drug with the Radix Stemonae, parasite killing; Radix Sophorae Flavescentis and Herba Solidaginis are ministerial drug, the heat clearing away antibacterial; Diacetyl nitrilo acetic acid ethylenediamine is an adjuvant drug, is used to reduce the intestinal capillary permeability, quick-acting haemostatic powder.
One of according to the present invention, the method for preparing of the veterinary drug compound preparation of said treatment coccidiosis, preferred following:
A. the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis, diacetyl nitrilo acetic acid ethylenediamine are carried out micronizing respectively, cross 600 mesh sieves, by the proportioning mixing, packing promptly gets pulvis.
B. get the Radix Stemonae, Radix Sophorae Flavescentis, the Herba Solidaginis 20～30h that is soaked in water by proportioning, 70～80 ℃ of heating and refluxing extraction 5～6 hours are filtered; Filtrate decompression concentrate the extract extractum of 1.3～1.5g/mL, add diacetyl nitrilo acetic acid ethylenediamine by proportioning, stir; Adding then granulates uses the adjuvant glucose, integrates and granulates, and reduced vacuum is dry; After the sieve granulate, packing promptly gets compound recipe QIUJING granule.
C. the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis were pulverized 80 mesh sieves, claimed by proportioning that the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis mix, and added the Radix Stemonae, Radix Sophorae Flavescentis and Herba Solidaginis gross weight 7-10 water doubly; Soak 18-24h, 70～80 ℃ heating and refluxing extraction 5-6 hour, filter; In filtrating, add diacetyl nitrilo acetic acid ethylenediamine, stir and make its dissolving, cooling by proportioning; Packing promptly gets compound recipe QIUJING oral liquid.
In the preparation process of different dosage form, or have acceptable accessories to add, its dosage bacterium is by the ability prior art, and these belong to well-known to those skilled in the art.
The application of the veterinary drug compound preparation of treatment coccidiosis of the present invention is used to prevent and treat fowl poultry coccidiosis, and method for using is following:
Pulvis and pre-mixing agent adopt to mix raises administration, and every 1kg feedstuff adds these article 10-20g; Granule and oral liquid adopt and mix the drink administration, add these article 10-20g in every 1kg drinking-water.
How toxic insecticidal constituent is in the Chinese medicine preparation of prior art treatment coccidiosis, like Radix Dichroae, Fructus Bruceae, the Radix Pulsatillae etc., limited its practical application.And the veterinary drug compound preparation property of medicine of treatment coccidiosis of the present invention is moderate, does not have toxic and side effects.And adopt the Chinese and Western combination, diacetyl nitrilo acetic acid ethylenediamine (ethylenediamine diaceturate) can quick-acting haemostatic powder, reduces poultry and infects behind the coccidiosis mortality rate because of severe loss of blood.
Chinese medicine of the present invention and chemical medicine composition of prescription can reduce the chemical sproof generation of chemical medicine, and certain potentiation is arranged.Prescription of the present invention,, is difficult for producing drug resistance in conjunction with practice on effective parasiticidal basis from coccidiosis Chinese veterinarian theory, and drug residue is low, and suppresses the generation of complication, the effect of performance treating both the principal and secondary aspects of a disease.Each component material is easy to get, and production technology is simple, convenient drug administration, greatly reduces production cost.
The specific embodiment
Below in conjunction with embodiment the present invention is further specified, but be not limited thereto.
Embodiment 1: pulvis
Get Radix Stemonae 30g, Radix Sophorae Flavescentis 20g, Herba Solidaginis 10g, diacetyl nitrilo acetic acid ethylenediamine 0.5g and carry out jet mill and pulverize, pulverize the back and cross 600 mesh sieves, mixing, packing promptly gets the pulvis of the veterinary drug compound preparation of treating coccidiosis.
This product adds in the feedstuff, feeds for the fowl poultry that infects coccidiosis.Every 1kg feedstuff adds this product 15～20g.
Embodiment 2: granule
Radix Stemonae 60kg, Radix Sophorae Flavescentis 40kg and Herba Solidaginis 20kg are soaked in water behind the 24h, and amount of water was not advisable to have raw material, and 80 ℃ of heating and refluxing extraction 6 hours are filtered; Filtrate decompression is concentrated into the extract extractum of 1.3～1.5g/mL, adds the diacetyl nitrilo acetic acid ethylenediamine of 0.5kg, stirs and makes dissolving; Add glucose then, integrate and granulate, reduced vacuum is dry; After the sieve granulate, packing promptly gets the granule of the veterinary drug compound preparation of treating coccidiosis.
Embodiment 3: oral liquid
Behind Radix Stemonae 80kg, Radix Sophorae Flavescentis 55kg, the Herba Solidaginis 25kg water logging bubble 24h with 1125kg, 80 ℃ of heating and refluxing extraction 6 hours are filtered; Must filtrate, add the diacetyl nitrilo acetic acid ethylenediamine of 500g, stir and make dissolving; Cooling, packing promptly gets the oral liquid of the veterinary drug compound preparation of treating coccidiosis.
Chicken farm effect experiment
Six plant chicken house with group and purchase 100 of the assorted chickens of 1 age in days meat from Shandong, raise in the hen house of strict sterilization, feed with the standard compliant feedstuff that does not contain coccidiostat of autogamy, freely drink water.When brooding to 16 ages in days, at random 100 chickling are divided into 5 groups, 20 every group supply examination.
Test is divided into groups and administration: totally 5 groups of tests, and the blank group does not infect not administration; Infect the matched group not administration of falling ill; Supply 1 group of compound recipe pulvis that adopts embodiment 1 of examination, mix and raise administration, every 1kg feedstuff adds this product 15g; Supply to try 2 groups with diclazuril (available from Changzhou intelligent animals company limited), mix the drink administration, every 1L water adds these article 1mg; Supply examination to adopt Maduramicin pre-mixing agent (available from the abundant Biology Pharmacy Co., Ltd of Zhejiang health) for 3 groups, per 1 kilogram of feed is added 10mg, mixes and raises administration; Except that blank group and infection matched group, all the other are respectively organized in 18 ages in days and begin administration, logotype 7 days.
Test is with coccidian oocyst and infection method: test is provided by Shandong agricultural university animal medicine parasitic disease laboratory with the tender ear 1 coccidiosis spore egg capsule of liking to be beautiful, and after toxicity test, presses 10 * 10
4Individual/only contamination.Except that the blank group, during 20 ages in days, to the artificial oral vaccination contamination of chicken.
Process of the test: after the contamination of 20 ages in days, observed 7 record chicken spirit, appetite, feces situation continuously.During 28 ages in days, all cut open and kill, observe caecum lesion, the egg sac number (OPG) with Maxwell method calculating cecal content calculates the egg capsule value by field, angle therapy for clearing away heat.Estimate according to indexs such as survival rate, rate of body weight gain, pathological changes value, anticoccidial index (ACI), egg capsule values and respectively to organize curative effect of medication.The result sees table 1:
Table 1, anticoccidial experimental result
| Group | The chicken number | Survival rate % | Rate of body weight gain % | The pathological changes value | The egg capsule value | ACI |
| The blank group | 20 | 100.00 | 100.00 | 0.0 | 0 | 200.00 |
| Infect matched group | 20 | 75 | 57.14 | 39.56 | 12 | 80.58 |
| Supply 1 group of examination | 20 | 100.00 | 92.85 | 3.5 | 0 | 189.35 |
| Supply 2 groups of examinations | 20 | 95 | 85.71 | 4.0 | 1 | 175.71 |
| Supply 3 groups of examinations | 20 | 90 | 84.87 | 7.5 | 1 | 166.37 |
Evidence, product anticoccidial index of the present invention (ACI) is greater than 180, and is obvious to the chicken coccidiosis curative effect, and therapeutic effect is superior to solution of diclazuril and Maduramicin pre-mixing agent.
Claims (6)
1. a veterinary drug compound preparation of treating coccidiosis is characterized in that, is processed by the raw material of following weight portion:
The Radix Stemonae: 10-100 part, Radix Sophorae Flavescentis: 10-100 part, Herba Solidaginis: 10-100 part,
Diacetyl nitrilo acetic acid ethylenediamine: be 0.5～5% of the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis gross weight.
2. the veterinary drug compound preparation of treatment coccidiosis as claimed in claim 1 is characterized in that the parts by weight of raw materials proportioning is following:
Radix Stemonae 10-50 part, Radix Sophorae Flavescentis 10-50 part, Herba Solidaginis 10-50 part, diacetyl nitrilo acetic acid ethylenediamine is 0.5～1% of the Radix Stemonae, Radix Sophorae Flavescentis, a Herba Solidaginis gross weight.
3. the veterinary drug compound preparation of treatment coccidiosis as claimed in claim 1 is characterized in that proportioning raw materials is following: Radix Stemonae 30g, Radix Sophorae Flavescentis 20g, Herba Solidaginis 10g, diacetyl nitrilo acetic acid ethylenediamine 1g.
4. like the veterinary drug compound preparation of each described treatment coccidiosis of claim 1～3, it is characterized in that this compound preparation is processed oral liquid, granule, pulvis or pre-mixing agent.
5. like method for preparing of the veterinary drug compound preparation of each described treatment coccidiosis of claim 1～4, step is one of following:
A. the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis, diacetyl nitrilo acetic acid ethylenediamine are carried out micronizing respectively, cross 600 mesh sieves, by the proportioning mixing, packing promptly gets pulvis;
B. get the Radix Stemonae, Radix Sophorae Flavescentis, the Herba Solidaginis 20～30h that is soaked in water by proportioning, 70～80 ℃ of heating and refluxing extraction 5～6 hours are filtered; Filtrate decompression concentrate the extract extractum of 1.3～1.5g/mL, add diacetyl nitrilo acetic acid ethylenediamine by proportioning, stir; Adding then granulates uses the adjuvant glucose, integrates and granulates, and reduced vacuum is dry; After the sieve granulate, packing promptly gets compound recipe QIUJING granule;
C. the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis were pulverized 80 mesh sieves, claimed by proportioning that the Radix Stemonae, Radix Sophorae Flavescentis, Herba Solidaginis mix, and added the Radix Stemonae, Radix Sophorae Flavescentis and Herba Solidaginis gross weight 7-10 water doubly; Soak 18-24h, 70～80 ℃ heating and refluxing extraction 5-6 hour, filter; Filtrate decompression is concentrated into 1/3～2/3 of original volume, adds diacetyl nitrilo acetic acid ethylenediamine by proportioning, stirs and makes its dissolving; Cooling, packing promptly gets compound recipe QIUJING oral liquid.
6. the application of the veterinary drug compound preparation of each said treatment coccidiosis of claim 1～3 is used to prevent and treat fowl poultry coccidiosis, and method for using is following:
Pulvis and pre-mixing agent adopt to mix raises administration, and every 1kg feedstuff adds these article 10-20g; Granule and oral liquid adopt and mix the drink administration, and every 1kg feeds and adds these article 10-20g in the water.
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| CN105396033B (en) * | 2015-11-30 | 2019-03-05 | 河南大德广动物药业有限公司 | A kind of Chinese medicine preparation and preparation method thereof for treating poultry globidiosis |
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