CN104758390A - Botanical drug compound preparation for preventing and treating porcine diarrhea and preparation method thereof - Google Patents
Botanical drug compound preparation for preventing and treating porcine diarrhea and preparation method thereof Download PDFInfo
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- CN104758390A CN104758390A CN201410751726.9A CN201410751726A CN104758390A CN 104758390 A CN104758390 A CN 104758390A CN 201410751726 A CN201410751726 A CN 201410751726A CN 104758390 A CN104758390 A CN 104758390A
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Abstract
The invention discloses a botanical drug compound preparation for preventing and treating porcine diarrhea and a preparation method thereof. The botanical drug compound preparation comprises the following components by weight: 20 to 40 g of purslane, 10 to 20 g of pasque flower, 10 to 20 g of root of kudzu vine, 10 to 20 g of pomegranate rind, 5 to 20 g of coptis and 5 to 20 g of Radix Astragali. The botanical drug compound preparation is prepared by crushing the above-mentioned components or crushing and extracting the above-mentioned components, and adding a proper amount of accessory materials. The botanical drug compound preparation is capable of clearing away heat and toxic materials and relieving diarrhea with astringents; and since the preparation is prepared through combined usage of the theory of traditional Chinese medicine and modern technology, the preparation can effectively reduce drug residues, prevent drug resistance, effectively protect intestinal mucosa and reduce occurrence of adverse reactions.
Description
Technical field
The invention belongs to field of traditional Chinese veterinary, relate to a kind of plant drug compound preparation preventing and treating diarrhea of pigs and preparation method thereof.
Background technology
Along with the change of developing by leaps and bounds with feeding manner and scale of pig industry, make swine diseases occurrence regularity there occurs change, especially the state of an illness of diarrhea of pigs is more and more serious, has carried out a series of new problem, more and more receive the concern of people to industrial belt of raising pigs.
Diarrhea of pigs pathogenesis is virus, antibacterial breeds mainly through entering intestinal epithelial cell after digestive tract and respiratory tract infection, directly cause the epithelial cell damage of small intestinal, degeneration, intestinal villi atrophy, come off, add the osmotic pressure in intestinal, serious diarrhoea will be caused like this.
The emergence and development of plant amedica has long history, and it applies to veterinary and starts habituation of wild animal and the period of being changed into domestic animal when tracing back to the mankind.At present due to a large amount of uses of domestic and international antibiotic, chemicals, make a lot of pathogen create Resistant strain, meanwhile, drug residue becomes food hygiene department problem to be solved.And plant amedica system is natural drug, has and have no side effect and not easily produce the advantages such as drug resistance.Thus, plant amedica control diarrhea of pigs disease is used more and more to be subject to people's attention.
Summary of the invention
According to tcm theory, prescription is processed be prepared from by Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis Chinese medicine of the five flavours, has effect of heat-clearing and toxic substances removing, relieving diarrhea with astringents.In side, Herba Portulacae has heat-clearing and toxic substances removing, cooling blood for hemostasis, effect of dysentery relieving; The Radix Pulsatillae has heat-clearing and toxic substances removing, effect of eliminating pathogenic heat from blood to cure dysentery; Radix Puerariae has promoting the production of body fluid to quench thirst, effect of yang invigorating antidiarrheal; Pericarpium Granati relieving diarrhea with astringents, hemostasis, anthelmintic; Rhizoma Coptidis has heat clearing and damp drying, effect of eliminating fire and detoxication.
The present invention adopts following proposal to be achieved.
1. prevent and treat the plant drug compound preparation of diarrhea of pigs, it is characterized in that, be prepared from by the plant drug material medicine of following weight proportion:
Herba Portulacae 20-40g, Radix Pulsatillae 10-20g, Radix Puerariae 10-20g, Pericarpium Granati 10-20g, Rhizoma Coptidis 5-20g, Radix Astragali 5-20g.
2. prevent and treat the plant drug compound preparation of diarrhea of pigs, it is characterized in that, be prepared from by the plant drug material medicine of following weight proportion:
Herba Portulacae 25-35g, Radix Pulsatillae 12-18g, Radix Puerariae 12-18g, Pericarpium Granati 12-18g, Rhizoma Coptidis 10-15g, Radix Astragali 10-15g.
3. prevent and treat the plant drug compound preparation of diarrhea of pigs, it is characterized in that, be prepared from by the plant drug material medicine of following weight proportion:
Herba Portulacae 30g, Radix Pulsatillae 15g, Radix Puerariae 15g, Pericarpium Granati 15g, Rhizoma Coptidis 12g, Radix Astragali 12g.
4. the present invention also comprises the preparation method of the plant drug compound preparation of control diarrhea of pigs, it is characterized in that Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis gomi herbs, pulverizes, mix and get final product.
5. the preparation method of preferred plant drug compound preparation, is characterized in that Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis gomi herbs to be ground into impalpable powder, sieves, and mixing, to obtain final product.
6. the preparation method of more preferred plant drug compound preparation, is characterized in that, by Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis gomi herbs, being ground into impalpable powder, adding adjuvant, and mixing, is prepared into powder, granule.
7. the preparation method of highly preferred plant drug compound preparation, is characterized in that:
(1) Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis gomi herbs are weighed respectively, cleaned and make coarse powder;
(2) Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis five tastes plant amedica add alcohol reflux 2-4h/ time of the 70-90 (v/v) of 10-12 multiple dose, each backflow 2-4 time, and recovery ethanol, is condensed into extractum, is dried to powder;
(3) powder of above-mentioned drying is added the adjuvants such as dextrin and make powder, granule.
The preparation method of the plant drug compound preparation of control diarrhea of pigs of the present invention comprise medical material pulverizing, sieve, the step such as mixing, the present invention effectively can improve the extraction yield of effective ingredient, improves bioavailability, reduces the loss of effective ingredient.
Grinding particle size reaches about 75 μm, the effective ingredient in medical material is fully exposed, is conducive to the digestion of pig, absorption, that substantially increase the medical material of medicine with contact area that is intestinal, has both saved vegetable drug resource, and suitably can improve drug effect again.
The present invention uses modern extraction process, makes the effective ingredient of vegetable drug reach maximization.
Test example
The treatment of piglet pujos blancos
1.1 test material
The ternary pigs of piglet pujos blancos is suffered from wean, biochemical reagents, plant extract.
1.2 test method
1.2.1 the selection of the sick pig of piglet pujos blancos
This test and Selection suffers from diarrhoea, white or the canescence starchiness of milk ejection is smelt as of rotten fish feces, root of the tail veutro, pig farm, Beijing three way cross lean meat piglet that perianal is stained with the typical piglet pujos blancos clinical symptoms such as feces is primary election object, the anus cotton swab of the doubtful piglet pujos blancos affected pig of aseptic collection and sick dead pig inflammation mucous membrane of small intestine pathological material of disease, by the classical method of inspection of bacteriology, through separation and Culture, morphologic observation, staining reaction, the qualification such as biochemical test and the agglutination test of antigen serotype confirms, its cause of disease mainly O8:F4, the Escherichia coli of O138:F4 serotype, make a definite diagnosis accordingly this pig farm piglet to suffer from the disease the piglet pujos blancos caused for Escherichia coli sick.
1.2.2
Select this 25 ~ 35 age in days, body weight is 5 ~ 6.5kg naturally suffers from Hakuri ablactational baby pig 150, after confirming that piglet did not use any Drug therapy, after beating overbit by head, weighing, brood piglet is divided into 5 groups at random: namely high dose group of the present invention is fed the daily ration containing embodiment 6, the daily ration that middle dosage group is fed containing embodiment 4, low dose group is fed the daily ration containing embodiment 2, positive control (ill not administration) group and blank group are fed and are mixed with the daily ration of starch, often organize each 30.All test group routes of administration are to mix raises, and point 2 times/d (interval 8 ~ 10h), is used in conjunction 3d.Set up case history archive by piglet overbit, from administration same day, to observe every day and by group by the mental status of head record piglet, diet, diarrhoea degree and feces character, improvement required time etc., the observation period is 7d.Weigh respectively in 10d after observation period terminates, add up the Average weight increasing a day (Average weight increasing a day of dead pig is designated as 0) of each group, grouping and medicine-feeding test process are in table 1 in detail.
Table 1 divides into groups and medicine-feeding test disposition
1.3 result of the test
As seen from the experiment, height of the present invention, in, dosage group cure rate is respectively: 73.33%, 83.33%, 70%, daily gain is respectively 0.130 ± 0.022,0.131 ± 0.025,0.115 ± 0.012, and it is dead without piglet, illustrate that the present invention of Three doses is all effective to treatment piglet pujos blancos, but have data can find out of the present invention high, medium and low in the effect of dosage group best.
Table 2 different disposal situation is to the treatment situation of piglet pujos blancos pig
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further detailed explanation.
Embodiment 1
The plant drug compound preparation of prevention diarrhea of pigs, is made up of agents: Herba Portulacae 20g, Radix Pulsatillae 10g, Radix Puerariae 10g, Pericarpium Granati 10g, Rhizoma Coptidis 5g, Radix Astragali 5g, and pulverized 200 sieves, mixing, to obtain final product.
Embodiment 2
The plant drug compound preparation of control diarrhea of pigs, is made up of agents: Herba Portulacae 20g, Radix Pulsatillae 10g, Radix Puerariae 10g, Pericarpium Granati 10g, Rhizoma Coptidis 5g, Radix Astragali 5g.
The plant drug compound preparation of control diarrhea of pigs, be made up of following steps:
(1) Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis gomi herbs are weighed respectively, cleaned and make coarse powder;
(2) Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis five tastes plant amedica add alcohol reflux 2h/ time of 70 (v/v) of 10 multiple doses, and each backflow 2 times, reclaims ethanol, be condensed into extractum, be dried to powder;
(3) powder of above-mentioned drying is added the adjuvants such as dextrin and make powder, granule.
Embodiment 3
The plant drug compound preparation of prevention diarrhea of pigs, is made up of agents: Herba Portulacae 30g, Radix Pulsatillae 15g, Radix Puerariae 15g, Pericarpium Granati 15g, Rhizoma Coptidis 12g, Radix Astragali 12g, and pulverized 200 sieves, mixing, to obtain final product.
Embodiment 4
The plant drug compound preparation of control diarrhea of pigs, is made up of agents: Herba Portulacae 30g, Radix Pulsatillae 15g, Radix Puerariae 15g, Pericarpium Granati 15g, Rhizoma Coptidis 12g, Radix Astragali 12g.
Prevent and treat a plant drug compound preparation for diarrhea of pigs, be made up of following steps:
(1) Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis gomi herbs are weighed respectively, cleaned and make coarse powder;
(2) Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis five tastes plant amedica add alcohol reflux 3h/ time of 80 (v/v) of 11 multiple doses, and each backflow 3 times, reclaims ethanol, be condensed into extractum, be dried to powder;
(3) powder of above-mentioned drying is added the adjuvants such as dextrin and make powder, granule.
Embodiment 5
The plant drug compound preparation of prevention diarrhea of pigs, is made up of agents: Herba Portulacae 40g, Radix Pulsatillae 20g, Radix Puerariae 20g, Pericarpium Granati 20g, Rhizoma Coptidis 20g, Radix Astragali 20g, and pulverized 200 sieves, mixing, to obtain final product.
Embodiment 6
The plant drug compound preparation of control diarrhea of pigs, is made up of agents: Herba Portulacae 40g, Radix Pulsatillae 20g, Radix Puerariae 20g, Pericarpium Granati 20g, Rhizoma Coptidis 20g, Radix Astragali 20g.
The plant drug compound preparation of control diarrhea of pigs, be made up of following steps:
(1) Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis gomi herbs are weighed respectively, cleaned and make coarse powder;
(2) Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis five tastes plant amedica add alcohol reflux 4h/ time of 90 (v/v) of 12 multiple doses, and each backflow 4 times, reclaims ethanol, be condensed into extractum, be dried to powder;
(3) powder of above-mentioned drying is added the adjuvants such as dextrin and make powder, granule.
Claims (7)
1. prevent and treat the plant drug compound preparation of diarrhea of pigs, it is characterized in that by Herba Portulacae (Portulaca oleracea L.), the Radix Pulsatillae (Pulsatillachinensis (Bge.) Regel), Radix Puerariae (Pueraria lobata (Willd.) Ohwi), Pericarpium Granati (Punica granatum L), Rhizoma Coptidis (Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao, Coptis teeta wall.) composition, it is prepared from by following weight proportion:
Herba Portulacae 20-40g, Radix Pulsatillae 10-20g, Radix Puerariae 10-20g, Pericarpium Granati 10-20g, Rhizoma Coptidis 5-20g, Radix Astragali 5-20g.
2. plant drug compound preparation according to claim 1, is characterized in that, is prepared from by the plant drug material medicine of following weight proportion:
Herba Portulacae 25-35g, Radix Pulsatillae 12-18g, Radix Puerariae 12-18g, Pericarpium Granati 12-18g, Rhizoma Coptidis 10-15g, Radix Astragali 10-15g.
3. plant drug compound preparation according to claim 2, is characterized in that, is prepared from by the plant drug material medicine of following weight proportion:
Herba Portulacae 30, the Radix Pulsatillae 15, Radix Puerariae 15, Pericarpium Granati 15, Rhizoma Coptidis 12, Radix Astragali 12g.
4. plant drug compound preparation preparation method according to claim 1, is characterized in that Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis gomi herbs, pulverizes, mixes and get final product.
5. plant drug compound preparation preparation method according to claim 1, is characterized in that, by Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis gomi herbs, being ground into impalpable powder, sieving, and mixing, to obtain final product.
6. the preparation method of plant drug compound preparation according to claim 1, it is characterized in that by Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati,
Rhizoma Coptidis gomi herbs, is ground into impalpable powder, adds adjuvant, and mixing, is prepared into powder, granule.
7. the preparation method of plant drug compound preparation according to claim 1, is characterized in that:
(1) Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis gomi herbs are weighed respectively, cleaned and make coarse powder.
(2) Herba Portulacae, the Radix Pulsatillae, Radix Puerariae, Pericarpium Granati, Rhizoma Coptidis Chinese medicine of the five flavours add alcohol reflux 2-4h/ time of the 70-90 (v/v) of 10-12 multiple dose, and each backflow 2-4 time, recovery ethanol, is condensed into extractum, is dried to powder.
(3) powder of above-mentioned drying is added the adjuvants such as dextrin and make powder, granule.
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| CN105250460A (en) * | 2015-10-21 | 2016-01-20 | 北京康华远景科技股份有限公司 | Drug composition for treating rabbit diarrhea and preparation methods of drug composition |
| CN112843148A (en) * | 2021-01-27 | 2021-05-28 | 河南九鼎农牧发展有限公司 | Medicine for treating diarrhea of piglets |
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Patent Citations (3)
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| CN102697888A (en) * | 2012-05-08 | 2012-10-03 | 广州市和生堂动物药业有限公司 | Traditional Chinese medicine fermented preparation for preventing and treating piglet diarrhea and preparation method thereof |
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Cited By (2)
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| CN105250460A (en) * | 2015-10-21 | 2016-01-20 | 北京康华远景科技股份有限公司 | Drug composition for treating rabbit diarrhea and preparation methods of drug composition |
| CN112843148A (en) * | 2021-01-27 | 2021-05-28 | 河南九鼎农牧发展有限公司 | Medicine for treating diarrhea of piglets |
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Inventor after: Xiao Chuanming Inventor after: Zhuo Lixin Inventor after: Ping Zhiguang Inventor after: Liu Feifei Inventor after: Yin Ziyu Inventor after: Huang Yuanrong Inventor after: Wei Xiulian Inventor after: Zhang Liyan Inventor after: Yang Baoliang Inventor after: Feng Xiuyan Inventor after: Lou Yingxia Inventor before: Xiao Chuanming Inventor before: Zhang Liyan Inventor before: Ping Zhiguang |
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