CN101698024A - Traditional Chinese medicine for treating respiratory diseases and promoting growth for swine and preparation method thereof - Google Patents

Traditional Chinese medicine for treating respiratory diseases and promoting growth for swine and preparation method thereof Download PDF

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Publication number
CN101698024A
CN101698024A CN200910235858A CN200910235858A CN101698024A CN 101698024 A CN101698024 A CN 101698024A CN 200910235858 A CN200910235858 A CN 200910235858A CN 200910235858 A CN200910235858 A CN 200910235858A CN 101698024 A CN101698024 A CN 101698024A
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China
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chinese medicine
pig
respiratory tract
medicine
herba
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CN200910235858A
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CN101698024B (en
Inventor
葛冰
刘钧
刘澜
莫云
张俊儒
葛代兴
田玲
邓利斌
黄建茹
丛日刚
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Shaoshan Dabeinong Animal Midicinal Co Ltd
BEIJING DABEINONG ANIMAL HEALTH TECHNOLOGY Co Ltd
Beijing Dabeinong Technology Group Co Ltd
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Shaoshan Dabeinong Animal Midicinal Co Ltd
BEIJING DABEINONG ANIMAL HEALTH TECHNOLOGY Co Ltd
Beijing Dabeinong Technology Group Co Ltd
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Priority to CN2009102358585A priority Critical patent/CN101698024B/en
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Abstract

The invention discloses a traditional Chinese medicine for treating respiratory diseases and promoting growth for swine and a preparation method thereof. The traditional Chinese medicine is composed of plantain herb, herba patriniae, hindu datura flower, perilla leaf, trichosanthes kirilowii maxim and gelsmium elegans. The traditional Chinese medicine of the invention can effectively prevent and treat livestock respiratory diseases, such as swine enzootic pneumonia, infectious pleuropneumonia of swine, porcine reproductive and respiratory syndrome (PRRS), swine plague, swine influenza and the like; meanwhile, the traditional Chinese medicine of the invention can improve animal productivity and promote animal growth. The traditional Chinese medicine of the invention has wide raw material resources, is safe and environmentally-friendly and has the advantages of simple preparation technology, low production cost and the like.

Description

One boar is with treating respiratory tract disease, somatotrophic Chinese medicine and preparation method thereof
Technical field
The present invention relates to a boar with treatment respiratory tract disease, somatotrophic Chinese medicine and preparation method thereof, belong to field of veterinary.
Background technology
At present, the M ﹠ M of porcine respiratory disease is all rising, and becomes a big problem of China's pig industry.The porcine respiratory disease mainly comprises swine enzootic pneumonia, porcine contagious pleuropneumonia, pig infectious atrophic rhinitis, Porcine reproductive and respiratory syndrome, pig streptococcicosis, pig lung plague, swine influenza etc.Especially in recent years, along with the continuous development of intensive pig production industry, the porcine respiratory disease presents the trend that is on the rise in China.The porcine respiratory disease is except the pig loss that only directly death causes, return that pig industry brings that feed conversion rate is low, poor growth, postponement listing and management go up serious economy loss such as vicious cycle, become one of problem that China modernization pig industry perplexs most, also become the No.1 disease of the global pig industry economic benefit of influence.
Because the cause of disease of porcine respiratory disease is a lot, brought many difficulties for treatment and prevention.There is uncertain factor in immunoprophylaxis, and effect is undesirable.The respiratory tract disease that treatment virus at present causes does not still have specific Western medicine, to bacterial respiratory tract disease, mainly use antibiotic or chemosynthesis antibacterials to treat, but antibacterial easily produce drug resistance to chemicals, and the chemicals toxic and side effects is bigger, often only cures the symptoms, not the disease.Adopt the chemotherapy respiratory tract disease can not improve breeding performonce fo animals, greatly reduce animal at during one's sickness feed conversion rate.Simultaneously, the use of chemicals also influences the safety of animal food, harm humans health.
Chinese herbal medicine has the dual function of medicine and nutrition, in control porcine respiratory disease, can effectively improve breeding performonce fo animals, promotes growth of animal.Chinese herbal medicine belongs to pure natural substance, aboundresources, cheap, have noresidue or low-residual, side effect little, do not produce characteristics such as drug resistance.Therefore, it is significant Chinese herbal medicine instead of chemical medicine to be prevented and treated livestock and birds respiratory disease.
Summary of the invention
The pig that the object of the present invention is to provide a kind of low cost, good effect, no drug residue is with treatment respiratory tract disease, somatotrophic Chinese medicine, thereby overcomes prior art Chinese medicine and western medicine and vaccine in treatment and prevent the deficiency of this type of disease.
Another object of the present invention provides this pig with treating respiratory tract disease, somatotrophic preparation method of Chinese medicine and application thereof.
The invention provides a boar with treating respiratory tract disease, somatotrophic Chinese medicine, the ingredient of this Chinese medicine is made up of Herba Plantaginis, Herba Patriniae, Flos Daturae, Folium Perillae, Fructus Trichosanthis and Herba Gelsemii Elegantis.
Wherein, the weight proportion of said medicine composition is as follows: Herba Plantaginis 5-25 part, Herba Patriniae 5-25 part, Flos Daturae 5-20 part, Folium Perillae 5-20 part, Fructus Trichosanthis 5-20 part, Herba Gelsemii Elegantis 3-15 part.
Further, the weight proportion of said medicine composition is as follows: Herba Plantaginis 8-20 part, Herba Patriniae 8-20 part, Flos Daturae 10-16 part, Folium Perillae 10-16 part, Fructus Trichosanthis 10-16 part, Herba Gelsemii Elegantis 5-12 part.
Further, the weight proportion of said medicine composition is as follows: 15 parts of Herba Plantaginiss, 15 parts of Herba Patriniae, 12 parts of Flos Daturaes, 12 parts of Folium Perillaes, 12 parts of Fructus Trichosanthis, 9 parts of Herba Gelsemii Elegantis.
The present invention also provides this pig with treating respiratory tract disease, somatotrophic preparation method of Chinese medicine, and it comprises the steps:
(1) takes by weighing each medicine material by weight ratio;
(2) will claim each medicine material maybe will claim after pulverizing, sieving each medicine material after water or alcohol extraction, concentrating, add adjuvant or complementary composition commonly used in the pharmacy again, be prepared from.
Wherein, the pig that makes of above-mentioned preparation method with the dosage form of treatment respiratory tract disease, somatotrophic Chinese medicine can be: pre-mixing agent, powder, powder, granule, oral liquid or injection.。
Each drug component in the Chinese medicine of the present invention and consumption thereof be to control principle according to the dialectical opinion of Chinese veterinarian's prescription, gets by repeatedly practising in a large number.Medicine of the present invention has heat-clearing and toxic substances removing, and the function of relieving cough and asthma cures mainly the porcine respiratory disease, but the while appetite stimulator improves the food animal quality, promotes fast growth of animal.Chinese medicine of the present invention can be used for preparing pig and uses the respiratory tract disease medicine.
Chinese medicine of the present invention also can be used for preparing pig and uses growth promotion medicine aspect.
Chinese medicine of the present invention also can add in the feedstuff, is used to prepare pig and uses resisting respiratory tract disease, somatotrophic feedstuff.
Pig of the present invention is with the advantage and the beneficial effect of treatment respiratory tract disease, somatotrophic Chinese medicine:
(1) the dialectical combined effect of controlling of executing of Chinese medicine performance Chinese medicinal formulae of the present invention, good effect, instant effect, treating both the principal and secondary aspects of a disease can be used for preventing and treating the porcine respiratory disease, have characteristics such as preparation technology is simple, with low cost, easy to use;
(2) medicine of the present invention has solved the contradiction between porcine respiratory disease and the poor growth, to the growing and fattening pigs growth promotion and the positive role of having improved food conversion ratio, can effectively improve pig body autoimmunity, prevents the generation of porcine respiratory disease;
(3) problems such as the medicine of the present invention drug residue avoiding present chemicals to use bringing and drug resistance generation ensure animal food safety and Environmental security;
(4) Chinese medicine of the present invention adopts the modern pharmaceutical technology to be prepared, and uses modern means of science and technology centering pharmaceutically active ingredient to carry out qualitative and quantitative detection, and constant product quality, controlled has the stronger market competitiveness.
, it should be understood that described embodiment only is for the present invention is described, rather than limit the scope of the invention by any way more specific description the present invention by the following example.
The specific embodiment
Embodiment 1 medication preparation of the present invention and use
(1) take by weighing the raw material that contains following weight:
25 parts of Herba Plantaginiss, 25 parts of Herba Patriniae, 20 parts of Flos Daturaes, 20 parts of Folium Perillaes, 20 parts of Fructus Trichosanthis, 15 parts of Herba Gelsemii Elegantis
(2) with claim in the step (1) each weight crude drug pulverize, sieve after, fully be mixed with into powder.
(3) drug use method of the present invention: respiratory tract disease, mixed feeding: pig, every 1kg feedstuff adds Chinese medicine 10g of the present invention, logotype 7 days.
Embodiment 2 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
5 parts of Herba Plantaginiss, 5 parts of Herba Patriniae, 5 parts of Flos Daturaes, 5 parts of Folium Perillaes, 5 parts of Fructus Trichosanthis, 3 parts of Herba Gelsemii Elegantis
(2) with claim in the step (1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours earlier after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into the thick paste shape; Filtering residue reuse water extraction 2 times extracted 2.5 hours for the first time, extracted 1.5 hours for the second time, filtered, and merging filtrate also is condensed into the thick paste shape; Merge extractum, add appropriate amount of starch and dextrin (or other adjuvant) at last, mix homogeneously is made soft material, granulates, and oven dry promptly is prepared into granule (every 1g is equivalent to crude drug in whole 2g).
(3) drug use method of the present invention: respiratory tract disease, mix drink: pig, every 1L water adds medicine 1.5g of the present invention, freely drinks logotype 7 days.
Embodiment 3 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
15 parts of Herba Plantaginiss, 15 parts of Herba Patriniae, 12 parts of Flos Daturaes, 12 parts of Folium Perillaes, 12 parts of Fructus Trichosanthis, 9 parts of Herba Gelsemii Elegantis
(2) with claim in the step (1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours earlier after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into the thick paste shape; Filtering residue reuse water extraction 2 times extracted 2.5 hours for the first time, extracted 1.5 hours for the second time, filtered, and merging filtrate also is condensed into the thick paste shape; Merge extractum, add appropriate amount of starch and dextrin (or other adjuvant) at last, mix homogeneously,, oven dry is pulverized, and promptly is prepared into powder (every 1g is equivalent to crude drug in whole 1g).
(3) drug use method of the present invention: respiratory tract disease, mixed feeding: pig, every 1kg feedstuff adds medicine 10g of the present invention, logotype 7 days.
Embodiment 4 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
20 parts of Herba Plantaginiss, 20 parts of Herba Patriniae, 16 parts of Flos Daturaes, 16 parts of Folium Perillaes, 16 parts of Fructus Trichosanthis, 12 parts of Herba Gelsemii Elegantis
(2) with claim in the step (1) each weight proportion crude drug pulverize after, after water soaks 1-2 hour with medical material, decoct with high heat then to boiling, reuse slow fire boiling 30 minutes is filtered, filtering residue adds water with slow fire boiling twice, each 1 hour.Merging filtrate, filtrate is concentrated the back, and to add ethanol ethanol content to the filtrate be 70%, filters, and filtrate recycling ethanol is concentrated into every 1ml and is equivalent to crude drug in whole 2g, and filtration, embedding, sterilization promptly are prepared into oral liquid.
(3) drug use method of the present invention: respiratory tract disease, mix drink: pig, every 1L water adds medicine 1.5ml of the present invention, freely drinks logotype 7 days.
Embodiment 5 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
8 parts of Herba Plantaginiss, 8 parts of Herba Patriniae, 10 parts of Flos Daturaes, 10 parts of Folium Perillaes, 10 parts of Fructus Trichosanthis, 5 parts of Herba Gelsemii Elegantis
(2) with claim in the step (1) each weight proportion crude drug pulverize after, after water soaks 1-2 hour with medical material, decoct with high heat then to boiling, reuse slow fire boiling 30 minutes is filtered, filtering residue was with slow fire boiling twice, each 1 hour.Merging filtrate, filtrate is concentrated the back, and to add ethanol ethanol content to the filtrate be 70%, filters, and filtrate recycling ethanol is concentrated into every 1ml and is equivalent to crude drug in whole 1g, and cold preservation, filtration, fine straining, embedding, sterilization promptly are prepared into injection.
(3) drug use method of the present invention: respiratory tract disease, intramuscular injection, each every 1kg body weight, pig 0.1-0.2ml/kg, 1 time on the one, logotype 7 days.
For showing medicine of the present invention to porcine respiratory disease and growth promotion effect, medicine of the present invention is carried out the clinical observation on the therapeutic effect test, below further set forth the beneficial effect of medicine of the present invention by testing example.
Test example 1
On December 10th, 2008, and 250 of piglets are bought on Ningxiang County pig farm, Changsha, Hunan, and about 20 kilograms of body weight were raised after 7 days, and symptoms such as cough, rapid breathing and asthma, the especially severe of coughing after feed and the strenuous exercise especially in the morning only appear in the part pig.Sick pig is through driveing, hearing very brief, successive dry cough, asthma after motion and the feeding, and the frequency of respiration per minute reaches 60-80 time, is tangible ventral breathing, even dehisces to breathe, and is the dog sitting posture, lassitude, and the pig body is become thin, and is reluctant to walk about.Raise main Cui and treated 5 days DeGrain with the sulfadiazine spice.135 pig morbidities are successively arranged, dead 3.Be diagnosed as swine enzootic pneumonia through pathologic finding.132 sick pigs are divided into 7 groups for examination.
Test grouping and administration: test is divided into 7 groups, tests 1 group of Chinese medicine that adopts embodiment 1 preparation, the mixed feeding administration, and the per kilogram feedstuff adds Chinese medicine 10g of the present invention; Test 2 groups and adopt embodiment 2 preparations, mix the drink administration, every 1L water adds Chinese medicine 1.5g of the present invention, freely drinks; Test 3 groups and adopt embodiment 3 preparations, the mixed feeding administration, the per kilogram feedstuff adds Chinese medicine 10g of the present invention; Test 4 groups and adopt embodiment 4 preparations, mix the drink administration, every 1L water adds Chinese medicine 1.5ml of the present invention, freely drinks; Test 5 groups and adopt embodiment 5 preparations, intramuscular administration; The tylosin phosphonate group adopts 10% tylosin phosphonate pre-mixing agent (autogamy), mixed feeding, and the per kilogram feedstuff adds 1g; The not administration of blank group; All the other respectively organized logotype 7.Continue after the off-test to observe 14, statistical results see Table 1.
Table 1 medicine of the present invention is added up the swine enzootic pneumonia curative effect
Result of the test shows: compare with the blank group, 6 test group all have significant curative effect to swine enzootic pneumonia; Compare with the tylosin phosphonate group, 5 groups of medicine of the present invention will be got well instant effect to the swine enzootic pneumonia prevention effect.Palatability of drugs of the present invention is good, and test pig does not only have the refusing to eat phenomenon, has no side effect and untoward reaction.
Test example 2
In November, 2008, Tianmen City pig farm, Hubei 200 bull 40-60 kilogram big porkers, part pig dyspnea, loss of appetite, hyperpyrexia only occur and delay and phenomenon such as do not move back.Dead pig is only cutd open inspection and shows as hydroabdomen and the hemorrhage enlargement of inguinal lymph nodes, and there is jagged small red dot at the edge of spleen, and pulmonary is cake shape pathological changes.Be diagnosed as porcine contagious pleuropneumonia.With 35 of sick pigs and only 180 isolation in time of infection pig, polluted place and pig house carry out strict sterilization.Adopt embodiment 2 preparations medicine of the present invention to treat to 35 sick pigs of isolated rearing, mix the drink administration, every 1L water adds Chinese medicine 3g of the present invention, freely drinks; Only adopt embodiment 1 preparation medicine of the present invention to infecting pig, the mixed feeding administration, the per kilogram feedstuff adds Chinese medicine 10g of the present invention.Through using medicine of the present invention to pay a return visit after 7 days continuously, except that 5 serious sick pig death, all the other 30 sick pigs are almost recovered.Infect swinery and disease do not occur.
Test example 3
In January, 2009, there are nearly 1000 big porkers on the pig farm, Tangshan, and the part pig is heating suddenly only, and appetite is useless exhausted; Muscle, arthralgia are reluctant to stand; Rapid breathing, ventral breathing, and spasmodic cough is arranged; Whole skin is rubescent, and eye and nose have symptoms such as mucus outflow.Clinical diagnosis is a swine influenza.Selecting wherein, 185 big porkers of serious symptom are divided into 4 groups for examination.
Test grouping and administration: test is divided into 4 groups, tests 1 group of Chinese medicine that adopts embodiment 3 preparations, the mixed feeding administration, and the per kilogram feedstuff adds Chinese medicine 10g of the present invention; Test 2 groups and adopt embodiment 4 preparations, mix the drink administration, every 1L water adds Chinese medicine 1.5ml of the present invention, freely drinks; Test 3 groups and adopt herbal medicine Antiphlogistic Powder of Schizonepetae and Ledebouriellae powder, the mixed feeding administration, the per kilogram feedstuff adds Antiphlogistic Powder of Schizonepetae and Ledebouriellae 10g; The not administration of blank group; All the other respectively organized logotype 7.Continue after the off-test to observe 2, statistical results see Table 2.
Table 2 medicine of the present invention is added up the swine flue curative effect
Result of the test shows: medicine of the present invention and Antiphlogistic Powder of Schizonepetae and Ledebouriellae all have good prevention effect to swine flue, and curative effect of medication of the present invention is slightly better than Antiphlogistic Powder of Schizonepetae and Ledebouriellae.
Test example 4
In May, 2009, carry out the growth promotion effect test of medicine of the present invention on the kind pig farm, Yutian, Hebei of big northern agricultural group animal health Technical Research Center cooperation.Select 240 of DLY three way cross ablactational baby pig, be divided into 4 test group (3 repetitions of each test group, each repeats 20): test 1 group and adopt embodiment 1 preparation, the mixed feeding administration, the per kilogram feedstuff adds Chinese medicine 10g of the present invention; Test 2 groups and adopt embodiment 3 preparations, the mixed feeding administration, the per kilogram feedstuff adds Chinese medicine 10g of the present invention; Colistine sulfate pre-mixing agent group adopts 2% colistine sulfate pre-mixing agent (autogamy), mixed feeding, and the per kilogram feedstuff adds 2g; The blank group is not added any medicine, and the test daily ration of each group is made up of the identical basal diet of trophic level, and experimental period is 30 days.Duration of test is observed a pig health status every day, it is heavy to begin and finish the time-division another name in formal test, feed consumption rate, the body weight gains of record in experimental period calculates average daily gain, average daily material consumption and feedstuff-meat ratio, and observes situations such as a pig respiratory tract disease and dysentery.Result of the test adopts and adds up with SPSS 13.0 statistical softwares, sees Table 3.
Table 3 Chinese medicine of the present invention is added up piglet growth promotion effect test
Annotate: the different persons of same column shoulder mark represent significant difference (P<0.05)
Result of the test shows: compare with the blank group, all there is significant difference (P<0.05) in 3 medication groups at piglet end weight, daily gain, daily ingestion amount and feedstuff-meat ratio; Compare with colistine sulfate pre-mixing agent group, there is significant difference (P<0.05) in 2 groups of medicine of the present invention at piglet end weight, daily gain and daily ingestion amount, feedstuff-meat ratio difference is remarkable (P>0.05) not, points out Chinese medicine of the present invention to promote piglet growth by increasing the piglet feed intake; Compare between 2 group groups of medicine of the present invention, piglet end weight, daily gain, daily ingestion amount and feedstuff-meat ratio all do not have significant difference (P>0.05).

Claims (9)

1. a boar is with treatment respiratory tract disease, somatotrophic Chinese medicine, it is characterized in that ingredient is made up of Herba Plantaginis, Herba Patriniae, Flos Daturae, Folium Perillae, Fructus Trichosanthis and Herba Gelsemii Elegantis.
2. pig according to claim 1 is characterized in that the weight proportion of mentioned component is as follows: Herba Plantaginis 5-25 part, Herba Patriniae 5-25 part, Flos Daturae 5-20 part, Folium Perillae 5-20 part, Fructus Trichosanthis 5-20 part, Herba Gelsemii Elegantis 3-15 part with treatment respiratory tract disease, somatotrophic Chinese medicine.
3. pig according to claim 2 is characterized in that the weight proportion of mentioned component is as follows: Herba Plantaginis 8-20 part, Herba Patriniae 8-20 part, Flos Daturae 10-16 part, Folium Perillae 10-16 part, Fructus Trichosanthis 10-16 part, Herba Gelsemii Elegantis 5-12 part with treatment respiratory tract disease, somatotrophic Chinese medicine.
4. pig according to claim 3 is characterized in that the weight proportion of mentioned component is as follows: 15 parts of Herba Plantaginiss, 15 parts of Herba Patriniae, 12 parts of Flos Daturaes, 12 parts of Folium Perillaes, 12 parts of Fructus Trichosanthis, 9 parts of Herba Gelsemii Elegantis with treatment respiratory tract disease, somatotrophic Chinese medicine.
One kind as each described pig of claim 1-4 with treatment respiratory tract disease, somatotrophic preparation method of Chinese medicine, it comprises the steps:
(1) takes by weighing each medicine material by weight ratio;
(2) will claim each medicine material maybe will claim after pulverizing, sieving each medicine material after water or alcohol extraction, concentrating, add adjuvant or complementary composition commonly used in the pharmacy again, be prepared from.
6. pig according to claim 5 is characterized in that with treatment respiratory tract disease, somatotrophic preparation method of Chinese medicine the dosage form that makes is: pre-mixing agent, powder, powder, granule, oral liquid or injection.
7. each described pig of claim 1-4 is being used to prepare the application of pig aspect the respiratory tract disease medicine with treatment respiratory tract disease, somatotrophic Chinese medicine.
8. each described pig of claim 1-4 is being used to prepare the application of pig aspect the growth promotion medicine with treatment respiratory tract disease, somatotrophic Chinese medicine.
9. each described pig of claim 1-4 is being used to prepare the application of pig aspect resisting respiratory tract disease, growth-promoting feed with treatment respiratory tract disease, somatotrophic Chinese medicine.
CN2009102358585A 2009-10-28 2009-10-28 Traditional Chinese medicine for treating respiratory diseases and promoting growth for swine and preparation method thereof Active CN101698024B (en)

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CN103549206A (en) * 2013-11-10 2014-02-05 镇江天和生物技术有限公司 Method for preparing gelsemium elegans extract grain for pigs
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CN104222529A (en) * 2014-10-11 2014-12-24 青岛华仁技术孵化器有限公司 Feed for preventing porcine reproductive and respiratory syndrome
CN104970197A (en) * 2015-06-29 2015-10-14 何以安 Feed additive for preventing infectious pleuropneumonia of goat
CN105396089A (en) * 2015-11-21 2016-03-16 从江县勇鑫养殖场 Chinese herbal medicine formula for treating pig pleuropneumonia
CN107661452A (en) * 2017-11-01 2018-02-06 罗建平 Prevent and treat Chinese herbal feed additive of pig anemopyretic cold and preparation method thereof
CN110575479A (en) * 2019-10-21 2019-12-17 江苏农牧科技职业学院 Application of herba patriniae and traditional Chinese medicine composition for treating porcine reproductive and respiratory syndrome

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