CN101664485B - Traditional Chinese medicine for treating respiratory disease of livestock and preparation method thereof - Google Patents
Traditional Chinese medicine for treating respiratory disease of livestock and preparation method thereof Download PDFInfo
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- CN101664485B CN101664485B CN2009100935573A CN200910093557A CN101664485B CN 101664485 B CN101664485 B CN 101664485B CN 2009100935573 A CN2009100935573 A CN 2009100935573A CN 200910093557 A CN200910093557 A CN 200910093557A CN 101664485 B CN101664485 B CN 101664485B
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Abstract
The invention discloses a traditional Chinese medicine for treating respiratory disease of livestock and a preparation method thereof. The traditional Chinese medicine comprises five traditional Chinese medicinal materials of herba violae, turkey corn, aster, herba ephedra and radix scutellariae. The traditional Chinese medicine can be effectively used for treating diseases of swine enzootic pneumonia, swine contagious pleuropneumonia, porcine reproductive and respiratory syndrome, swine plague, swine influenza, infectious bronchitis of chicken, infectious laryngotracheitis of chicken and thelike, and has the advantages of environment protection without toxic and side effects, simple preparation process, low production cost and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of livestock and birds respiratory disease and preparation method thereof, belong to field of veterinary.
Background technology
In recent years, respiratory tract disease has become one of disease that aquaculture is the most common, harm is the most serious.Livestock and birds respiratory disease mainly comprises swine enzootic pneumonia, porcine contagious pleuropneumonia, pig infectious atrophic rhinitis, Porcine reproductive and respiratory syndrome, pig streptococcicosis, pig lung plague, swine influenza and infectious bronchitis of chicken, infectious laryngotracheitis of chicken, bird flu etc., and these diseases cause serious economy loss to aquaculture.It is reported that all there is mycoplasma pneumonia in the pig farm of U.S. 70%-80%, the porcine respiratory disease complex of finding first in the North America in 1997, pilosity are born in child care phase and later each growth stage, and sickness rate is usually at 30%-70%, and case fatality rate is up to 15%-20%.Swine fever also is the viral respiratory disease that a kind of infectiousness is strong, fatality rate is high, economic loss is serious.It is reported have more than 20 countries and regions to still have the swine fever case to exist in the worldwide approximately, as in August, 2000, Britain finds swine fevers in 3 tame farms, and causing year export amount is that Britain's pig industry of 1.26 hundred million pounds is given a heavy blow to.The harm that respiratory tract disease causes for the development of aviculture is paid close attention to by people always, and its mortality rate is generally at 10%-40%, and laying rate descends about 20%, and very the person descends 50%.According to foreign scholar's a special survey statistics, in the family of raising chickens in the north, South America, the treatment disbursement of respiratory tract disease accounts for 59% of all disease total expenditures, and wherein dead expenditure is 46.56%, and the medicine expenditure accounts for 65% of medical expense.As seen, respiratory tract disease has caused serious economy loss to aquaculture.
Because the cause of disease of respiratory tract disease is a lot, brought many difficulties for treatment and prevention.Though immunoprophylaxis is one of effective means,, often cause immuning failure or effect undesirable owing to reasons such as the existence of virulent strain and maternal antibody, vaccine qualities.Therefore, medical treatment just becomes one of requisite remedial measure behind the immuning failure.The respiratory tract disease that treatment virus at present causes does not still have specific Western medicine, to bacterial respiratory tract disease, main antibiotic or the chemosynthesis antibacterials used are treated, but antibacterial easily produces drug resistance to chemicals, and the chemicals toxic and side effects is bigger, often only cure the symptoms, not the disease, the integral body of disease is prevented and treated bring unfavorable factor.Simultaneously, the use of chemicals also influences the safety of animal food, harm humans health.
Chinese herbal medicine belongs to pure natural substance, contains multiple biological effective components, has antibiotic, antiinflammatory, is difficult for producing characteristics such as bacterial drug resistance, low toxicity, noresidue or low-residual, has medicine and nutrition dual-use function concurrently, not only takes stopgap measures but also effect a permanent cure.Therefore, Chinese herbal medicine instead of chemical medicine is prevented and treated livestock and birds respiratory disease and have bigger economic benefit and environment protection significance.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, the Chinese medicine of a kind of good effect, no drug residue and chemical sproof treatment livestock and birds respiratory disease is provided.
Another object of the present invention provides this treatment livestock and birds respiratory disease preparation method of Chinese medicine.
The invention provides a kind of Chinese medicine for the treatment of livestock and birds respiratory disease, the ingredient of this Chinese medicine is made up of Herba Violae, Herba corydalis edulis, Radix Asteris, Herba Ephedrae and Radix Scutellariae.
Wherein, the weight proportion of said medicine composition is as follows: Herba Violae 10-25 part, Herba corydalis edulis 5-20 part, Radix Asteris 5-20 part, Herba Ephedrae 5-20 part, Radix Scutellariae 3-15 part.
Further, the weight proportion of said medicine composition is as follows: Herba Violae 15-20 part, Herba corydalis edulis 10-18 part, Radix Asteris 10-18 part, Herba Ephedrae 10-18 part, Radix Scutellariae 5-12 part.
Further, the weight proportion of said medicine composition is as follows: 18 parts of Herba Violaes, 15 parts of Herba corydalis eduliss, 15 parts of Radix Asteriss, 15 parts in Herba Ephedrae, 7 parts of Radix Scutellariaes.
The present invention also provides this treatment livestock and birds respiratory disease preparation method of Chinese medicine, and it comprises the steps:
(1) takes by weighing each medicine material by weight ratio;
(2) will claim each medicine material maybe will claim after pulverizing, sieving each medicine material after water or alcohol extraction, concentrating, add adjuvant or complementary composition commonly used in the pharmacy again, be prepared from.
Wherein, the dosage form of the Chinese medicine of the treatment livestock and birds respiratory disease that makes of above-mentioned preparation method can be: pre-mixing agent, powder, powder, tablet, granule, oral liquid or injection.
The Chinese medicine of treatment livestock and birds respiratory disease of the present invention can be used for preparation treatment livestock and birds respiratory disease medicine.
Each drug component in the Chinese medicine of the present invention and consumption thereof be to control principle according to the dialectical opinion of Chinese veterinarian's prescription, gets by repeatedly practising in a large number.Chinese medicine of the present invention has heat-clearing and toxic substances removing, the function of relieving cough and asthma, be prepared into preparation pharmaceutically commonly used after, cure mainly livestock and birds respiratory disease.Chinese medicine of the present invention also can add in the feedstuff, is prepared into the feedstuff of anti-livestock and birds respiratory disease.
The advantage and the beneficial effect of medicine of the present invention are:
(1) the dialectical combined effect of controlling of executing of Chinese medicine performance Chinese medicinal formulae of the present invention, good effect, instant effect, noresidue, the difficult drug resistance that produces, treating both the principal and secondary aspects of a disease can be used for preventing and treating livestock and birds respiratory disease;
(2) Chinese medicine of the present invention adopts the modern pharmaceutical technology to be prepared, and uses modern means of science and technology centering pharmaceutically active ingredient to carry out qualitative and quantitative detection, and constant product quality, controlled has the stronger market competitiveness;
(3) raw material of Chinese medicine of the present invention is originated and is enriched, and preparation technology is simple, and is with low cost, easy to use, is beneficial to mass prevention and mass treatment.
, it should be understood that described embodiment only is for the present invention is described, rather than limit the scope of the invention by any way more specific description the present invention by the following example.
The specific embodiment
Embodiment 1 medication preparation of the present invention and use
(1) take by weighing the raw material that contains following weight:
Herba Violae 25g, Herba corydalis edulis 20g, Radix Asteris 20g, Herba Ephedrae 20g, Radix Scutellariae 15g
(2) with claim in the step (1) each weight crude drug pulverize, sieve after, fully be mixed with into powder.
(3) drug use method of the present invention: respiratory tract disease, mixed feeding: poultry, fowl, every 1kg feedstuff adds Chinese medicine 8g of the present invention, logotype 7 days.
Embodiment 2 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
Herba Violae 10g, Herba corydalis edulis 5g, Radix Asteris 5g, Herba Ephedrae 5g, Radix Scutellariae 3g
(2) with claim in the step (1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours earlier after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into the thick paste shape; Filtering residue reuse water extraction 2 times extracted 2.5 hours for the first time, extracted 1.5 hours for the second time, filtered, and merging filtrate also is condensed into the thick paste shape; Merge extractum, add appropriate amount of starch and dextrin (or other adjuvant) at last, mix homogeneously is made soft material, granulates, and oven dry promptly is prepared into granule (every 1g is equivalent to crude drug in whole 2g).
(3) drug use method of the present invention: respiratory tract disease, mix drink: poultry, fowl, every 1L water adds medicine 2g of the present invention, freely drinks logotype 5-7 day.
Embodiment 3 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
Herba Violae 18g, Herba corydalis edulis 15g, Radix Asteris 15g, Herba Ephedrae 15g, Radix Scutellariae 7g
(2) with claim in the step (1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours earlier after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into the thick paste shape; Filtering residue reuse water extraction 2 times extracted 2.5 hours for the first time, extracted 1.5 hours for the second time, filtered, and merging filtrate also is condensed into the thick paste shape; Merge extractum, add appropriate amount of starch and dextrin (or other adjuvant) at last, mix homogeneously,, oven dry is pulverized, and promptly is prepared into powder (every 1g is equivalent to crude drug in whole 1g).
(3) drug use method of the present invention: respiratory tract disease, mixed feeding: poultry, fowl, every 1kg feedstuff adds medicine 8g of the present invention, logotype 7 days.
Embodiment 4 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
Herba Violae 25g, Herba corydalis edulis 15g, Radix Asteris 20g, Herba Ephedrae 20g, Radix Scutellariae 10g
(2) with claim in the step (1) each weight proportion crude drug pulverize after, after water soaks 1-2 hour with medical material, decoct with high heat then to boiling, reuse slow fire boiling 30 minutes is filtered, filtering residue adds water with slow fire boiling twice, each 1 hour.Merging filtrate is concentrated into 90 milliliters with filtrate, and adding ethanol ethanol content to the filtrate is 70%, filters, and filtrate recycling ethanol is concentrated into every 1ml and is equivalent to crude drug in whole 2g, and filtration, embedding, sterilization promptly are prepared into oral liquid.
(3) drug use method of the present invention: respiratory tract disease, mix drink: poultry, fowl, every 1L water adds medicine 2ml of the present invention, freely drinks logotype 7 days.
Embodiment 5 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
Herba Violae 20g, Herba corydalis edulis 15g, Radix Asteris 15g, Herba Ephedrae 20g, Radix Scutellariae 10g
(2) with claim in the step (1) each weight proportion crude drug pulverize after, after water soaks 1-2 hour with medical material, decoct with high heat then to boiling, reuse slow fire boiling 30 minutes is filtered, filtering residue was with slow fire boiling twice, each 1 hour.Merging filtrate is concentrated into 80 milliliters with filtrate, and adding ethanol ethanol content to the filtrate is 70%, filters, and filtrate recycling ethanol is concentrated into every 1ml and is equivalent to crude drug in whole 1g, and cold preservation, filtration, fine straining, embedding, sterilization promptly are prepared into injection.
(3) drug use method of the present invention: respiratory tract disease, intramuscular injection, each every 1kg body weight, sheep, pig 0.1-0.2ml/kg, dog, rabbit 0.2ml, 2 times on the one, logotype 5-7 day.
Embodiment 6 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
Herba Violae 15g, Herba corydalis edulis 20g, Radix Asteris 20g, Herba Ephedrae 15g, Radix Scutellariae 10g
(2) with claim in the step (1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours earlier after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into extractum; Filtering residue reuse water extraction 2 times extracted 2.5 hours for the first time, extracted 1.5 hours for the second time, filter, merging filtrate also is condensed into extractum, adds appropriate amount of starch, magnesium stearate at last, granulation, tabletting, every 0.2g (every 1g is equivalent to crude drug in whole 2g) promptly is prepared into tablet.
(3) drug use method of the present invention: respiratory tract disease, dog, cat, every day the 2-4 sheet, rabbit, fowl 1-2 sheet, logotype 7 days.
For showing the prevention effect of medicine of the present invention to livestock and birds respiratory disease, medicine of the present invention is carried out the clinical observation on the therapeutic effect test, below further set forth the beneficial effect of medicine of the present invention by testing example.
Test example 1
In December, 2008, the Huairou District wild goose dwell the town certain pig farm 210 piglets are arranged, it is depressed most of piglet lethargy to occur, sagging, and ear droops, dyspnea, rapid, severe patient is ventral breathing, becomes thin, and is disorderly thick by hair, symptom, doubtful asthma and pleuropneumonia mixed infections such as the generation conjunctivitis that has.Select 120 of wherein sick pigs, be divided into 6 groups, every group of 20 piglet is for examination.
Test grouping and administration: test is divided into 6 groups, and medicine of the present invention adopts embodiment 1 preparation for 1 group, the mixed feeding administration, and the per kilogram feedstuff adds Chinese medicine 8g of the present invention; Medicine of the present invention adopts embodiment 3 preparations for 2 groups, the mixed feeding administration, and the per kilogram feedstuff adds Chinese medicine 8g of the present invention; Medicine of the present invention adopts embodiment 4 preparations for 3 groups, mixes the drink administration, and every 1L water adds Chinese medicine 2ml of the present invention, freely drinks; Medicine of the present invention adopts embodiment 5 preparations, intramuscular administration for 4 groups; The colistin sulfate group adopts 2% colistin sulfate pre-mixing agent (autogamy), the mixed feeding administration, and the per kilogram feedstuff adds 2g; The not administration of blank group; All the other respectively organized logotype 7.Continue after the off-test to observe 2, statistical results see Table 1.
Table 1 medicine of the present invention is added up the porcine respiratory curative effect of disease
Result of the test shows: compare with the blank group, 5 test group all have significant curative effect to the porcine respiratory disease; Compare with the colistin sulfate group, and 4 groups of medicine of the present invention (1 group-powder, 2 groups-powder, 3 groups-oral liquid, 4 groups-injection) effective to the porcine respiratory diseases prevention and treatment, instant effect.Medicine of the present invention has no side effect and untoward reaction, and 4 groups of (injection group) effects of Chinese medicine wherein of the present invention are best.
Test example 2
In November, 2008, the Huairou District wild goose dwell certain field, chicken farm raising of town 1000 surplus a Sanhuang chicken, 80 age in days sudden onset begin that indivedual chickens slow-witted upright peel off, spirit is depressed, thin water sample nose liquid is flowed out in the nostril, shaking the head appearred in the rear section chicken in 2-3 days, and mouth breathing, sneeze, eye conjunctiva inflammation, shed tears, symptom such as eyelid generation swelling, diarrhoea also appears in the minority chicken, feed intake obviously reduces, and the dried-up tarnish of feather loses weight.According to epidemiology, clinical symptoms, cut open inspection and change and laboratory diagnosis, be diagnosed as infectious coryza of chicken.Selecting wherein, 600 morbidity chickens supply examination.
Test grouping and administration: test is divided into 3 groups, and medicine of the present invention adopts embodiment 2 preparations for 1 group, mixes the drink administration, and every 1L water adds Chinese medicine 2g of the present invention, freely drinks logotype 7 days; 2 groups of medicines of the present invention adopt embodiment 6 preparations, 2 of every chicken every days, logotype 7 days; The amoxicillin group adopts 10% amoxicillin soluble powder (autogamy), mixes drink, and every 1L water adds 0.6 gram, logotype 7 days.Continue after the off-test to observe 14, the statistics chicken is cured number, death toll, and result of the test sees Table 2.
Table 2 medicine of the present invention is added up the infectious coryza of chicken curative effect
Result of the test: compare with the amoxicillin group, 2 groups of medicine of the present invention all have excellent curative to infectious coryza of chicken; Relatively, medicine of the present invention 1 group (granule group) is better than 2 groups of the present invention medicines (tablet group) curative effect between medicine group of the present invention.2 groups of medicine of the present invention all do not have recurrence in the observation period on the 14th after medication, the amoxicillin group has small part chicken recurrence in the observation period on the 14th, choose the recurrence chicken and change clothes 1 group of medicine of the present invention (granule), all cure after serveing on 5 days.
Claims (7)
1. Chinese medicine for the treatment of livestock and birds respiratory disease, it is characterized in that medicine material is made up of Herba Violae, Herba corydalis edulis, Radix Asteris, Herba Ephedrae and Radix Scutellariae, the weight proportion of said medicine raw material is as follows: Herba Violae 10-25 part, Herba corydalis edulis 5-20 part, Radix Asteris 5-20 part, Herba Ephedrae 5-20 part, Radix Scutellariae 3-15 part.
2. the Chinese medicine of treatment livestock and birds respiratory disease according to claim 1 is characterized in that the weight proportion of said medicine raw material is as follows: Herba Violae 15-20 part, Herba corydalis edulis 10-18 part, Radix Asteris 10-18 part, Herba Ephedrae 10-18 part, Radix Scutellariae 5-12 part.
3. the Chinese medicine of treatment livestock and birds respiratory disease according to claim 2 is characterized in that the weight proportion of said medicine raw material is as follows: 18 parts of Herba Violaes, 15 parts of Herba corydalis eduliss, 15 parts of Radix Asteriss, 15 parts in Herba Ephedrae, 7 parts of Radix Scutellariaes.
4. preparation method of Chinese medicine as each described treatment livestock and birds respiratory disease of claim 1-3, it comprises the steps:
(1) takes by weighing each medicine material by weight ratio;
(2) will claim each medicine material maybe will claim after pulverizing, sieving each medicine material after water or alcohol extraction, concentrating, add adjuvant or complementary composition commonly used in the pharmacy again, be prepared from.
5. the preparation method of Chinese medicine of treatment livestock and birds respiratory disease according to claim 4 is characterized in that the dosage form that makes is: powder, tablet, granule, oral liquid or injection.
6. the Chinese medicine of each described treatment livestock and birds respiratory disease of claim 1-3 is in the application that is used to prepare aspect the treatment livestock and birds respiratory disease medicine.
7. the Chinese medicine of each described treatment livestock and birds respiratory disease of claim 1-3 is in the application that is used to prepare aspect the anti-livestock and birds respiratory disease feedstuff.
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102640884B (en) * | 2012-05-22 | 2013-10-30 | 山东新希望六和集团有限公司 | Feed for treating mycoplasmal pneumonia of swine and preparation method |
| CN103656315B (en) * | 2013-12-23 | 2015-07-29 | 山东新希望六和集团有限公司 | Medicine being used for the treatment of porcine contagious pleuropneumonia and preparation method thereof |
| CN105285390A (en) * | 2015-10-21 | 2016-02-03 | 黑龙江省农业科学院畜牧研究所 | Feed additive capable of preventing and treating respiratory disease of Min pigs as well as preparation method and application of feed additive |
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| CN1634386A (en) * | 2004-09-21 | 2005-07-06 | 亿利资源集团公司 | Medicine for treating cough |
| CN1686439A (en) * | 2005-05-08 | 2005-10-26 | 北京正大绿洲医药科技有限公司 | Kelu drip pill used for phlegm transforming cough suppressing and its preparation method |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634386A (en) * | 2004-09-21 | 2005-07-06 | 亿利资源集团公司 | Medicine for treating cough |
| CN1686439A (en) * | 2005-05-08 | 2005-10-26 | 北京正大绿洲医药科技有限公司 | Kelu drip pill used for phlegm transforming cough suppressing and its preparation method |
Non-Patent Citations (2)
| Title |
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| 朱连勤等.中药防治鸡传染性呼吸道疾病的研究现况与展望.《中兽医学杂志》.2003,(第4期),35-39. * |
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