CN101664437B - Traditional Chinese medicine for treating coccidiosis and preparation method and application thereof - Google Patents
Traditional Chinese medicine for treating coccidiosis and preparation method and application thereof Download PDFInfo
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- CN101664437B CN101664437B CN2009100935520A CN200910093552A CN101664437B CN 101664437 B CN101664437 B CN 101664437B CN 2009100935520 A CN2009100935520 A CN 2009100935520A CN 200910093552 A CN200910093552 A CN 200910093552A CN 101664437 B CN101664437 B CN 101664437B
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Abstract
The invention discloses a traditional Chinese medicine for treating coccidiosis and a preparation method thereof. The traditional Chinese medicine comprises the ingredients of thick wood-fern rhizome, pomegranate rind, radix dichroa, radix sophorae falvescentis and field thistle. The traditional Chinese medicine can be effectively used for preventing and treating diseases of chicken coccidiosis, duck coccidiosis, rabbit coccidiosis, pig coccidiosis, dog coccidiosis and the like, and has the advantages of accurate treatment effect, simple preparation process, low production cost, no residue, convenient use and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of coccidiosis and its production and use, belong to field of veterinary.
Background technology
Coccidiosis is a kind of widely distributed, great parasite protozoacide of hazardness, is one of disease of the high control difficulty of sickness rate in the aquaculture.Domestic animal, poultry all can infect coccidiosis, and wherein chicken coccidiosis harm is especially serious, and its sickness rate reaches 50%-70%, and mortality rate reaches 20%-30%, reaches 80% when serious.In case fall ill, be difficult to radical cure, the chicken growth retardation of the anti-mistake of falling ill, the minimizing of laying eggs causes huge economic loss for global poultry husbandry.According to data, whole world every year because of coccidiosis cause with a toll of 1,500,000,000 dollars, wherein the year consumption of anticoccidial drug reaches 3.2 hundred million dollars.The U.S. spends in every year has 300,000,000 dollars on the anticoccidial approximately, wherein has 100,000,000 to be to spend on the medicine approximately.Britain estimated coccidiosis incidence rate 2%, mortality rate 0.5% in 2005.Coccidiosis has become the global disease that obstruction set reduction is supported the fowl production development.
At present, the effective method of control chicken coccidiosis is still chemoprophylaxis.Have 95% to be added with anticoccidial drug approximately in the feedstuff that use in U.S.'s broiler place now.In the method for all control chicken coccidiosis, chemicals still is in leading position.But a large amount of tests show that polypide has produced Drug resistance to part coccidiosis medicine, and exist the opposing of part intersection between the ionophore class medicine.In order to control coccidiosis better, often the exchange medicine improves production cost greatly.Simultaneously, the toxicity of chemicals, residual, immunosuppressant and drug resistance seriously perplex it to be used, and has a strong impact on the health with harm humans.More and more pay close attention to today of animal food safety people, study the big problem that new anticoccidial " green veterinary drug " becomes the veterinary drug research worker.
The Chinese herbal medicine toxic and side effects is low, but not only has the effect of the worm of killing, and can also enhancing body's immunological function, promotes animal growth, improves rate of body weight gain and breeding performonce fo animals.Therefore, prevent and treat coccidiosis with Chinese herbal medicine instead of chemical medicine and have bigger economic benefit and environment protection significance.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, the Chinese medicine of a kind of determined curative effect, no drug residue and chemical sproof treatment coccidiosis is provided.
Another object of the present invention provides this treatment coccidiosis preparation method of Chinese medicine and purposes.
The objective of the invention is to be achieved through the following technical solutions:
The invention provides a kind of Chinese medicine for the treatment of coccidiosis, the ingredient of this Chinese medicine is made up of Rhizoma Dryopteris Crassirhizomatis, Pericarpium Granati, Radix Dichroae, Radix Sophorae Flavescentis and Herba Cirsii.
Wherein, the weight proportion of mentioned component is as follows: Rhizoma Dryopteris Crassirhizomatis 2-25 part, Pericarpium Granati 5-20 part, Radix Dichroae 5-20 part, Radix Sophorae Flavescentis 3-15 part, Herba Cirsii 5-15 part.
Further, the weight proportion of mentioned component is as follows: Rhizoma Dryopteris Crassirhizomatis 15-22 part, Pericarpium Granati 10-18 part, Radix Dichroae 10-18 part, Radix Sophorae Flavescentis 6-10 part, Herba Cirsii 6-12 part.
Further, the weight proportion of mentioned component is as follows: 20 parts of Rhizoma Dryopteris Crassirhizomatiss, 15 parts of Pericarpium Granatis, 15 parts of Radix Dichroaes, 8 parts of Radix Sophorae Flavescentiss, 10 parts of Herba Cirsiis.
The present invention also provides the preparation method of Chinese medicine of this treatment coccidiosis, and it comprises the steps:
(1) takes by weighing each medicine material by weight ratio;
(2) each medicine material is pulverized and sieved back or each raw material after water or alcohol extraction, concentrating, add adjuvant or complementary composition commonly used in the pharmacy, be prepared from.
Wherein, the dosage form of the Chinese medicine of the treatment coccidiosis that makes of above-mentioned preparation method can be: powder, powder, tablet, granule, oral liquid or injection.
The Chinese medicine of treatment coccidiosis of the present invention can be used for preparation treatment coccidiosis medicine.
The Chinese medicine of treatment coccidiosis of the present invention especially is suitable for preparation treatment coccidiosis of domestic fowls medicine.
Each drug component in the pharmaceutical composition of the present invention and consumption thereof be to control principle according to the dialectical opinion of Chinese veterinarian's prescription, gets by repeatedly practising in a large number.Medicine of the present invention has heat-clearing and toxic substances removing, and parasite killing goes to amass, the function of astringing to arrest bleeding, be prepared into preparation pharmaceutically commonly used after, cure mainly poultry coccidiosis disease, particularly coccidiosis of domestic fowls etc.
The advantage and the beneficial effect of medicine of the present invention are:
(1) the dialectical combined effect of controlling of executing of Chinese medicine performance Chinese medicinal formulae of the present invention, determined curative effect, treating both the principal and secondary aspects of a disease can be used for preventing and treating diseases such as chicken coccidiosis, el pato's parasitosis, rabbit coccidiosis, pig coccidiosis, dog coccidiosis;
(2) Chinese medicine of the present invention adopts the modern pharmaceutical technology to be prepared, and uses modern means of science and technology centering pharmaceutically active ingredient to carry out qualitative and quantitative detection, and constant product quality, controlled has the stronger market competitiveness;
(3) curative effect of medication of the present invention is definite, toxic and side effects is little, drug residue free, the difficult drug resistance, free from environmental pollution that produces; Simultaneously, easy to use, be beneficial to mass prevention and mass treatment;
(4) medicine material of the present invention is originated and is enriched, and preparation technology is simple, and is with low cost, saved the coccidiostat medication expense widely.
, it should be understood that described embodiment only is for the present invention is described, rather than limit the scope of the invention by any way more specific description the present invention by the following example.
The specific embodiment
Embodiment 1 medication preparation of the present invention and use
(1) take by weighing the raw material that contains following weight:
Rhizoma Dryopteris Crassirhizomatis 25g, Pericarpium Granati 20g, Radix Dichroae 20g, Radix Sophorae Flavescentis 15g, Herba Cirsii 15g.
(2) with claim in the step (1) each weight crude drug pulverize, sieve after, fully be mixed with into powder.
(3) drug use method of the present invention: coccidiosis, mixed feeding: poultry, fowl, every 1kg feedstuff adds Chinese medicine 10g of the present invention, logotype 5-7 day.
Embodiment 2 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
Rhizoma Dryopteris Crassirhizomatis 2g, Pericarpium Granati 5g, Radix Dichroae 5g, Radix Sophorae Flavescentis 3g, Herba Cirsii 5g
(2) with claim in the step (1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours earlier after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into the thick paste shape; Filtering residue reuse water extraction 2 times extracted 2.5 hours for the first time, extracted 1.5 hours for the second time, filtered, and merging filtrate also is condensed into the thick paste shape; Merge extractum, add appropriate amount of starch and dextrin (or other adjuvant) at last, mix homogeneously is made soft material, granulates, and oven dry promptly is prepared into granule (every 1g is equivalent to crude drug in whole 2g).
(3) drug use method of the present invention: coccidiosis, mix drink: poultry, fowl, every 1L water adds medicine 1.5g of the present invention, freely drinks logotype 5-7 day.
Embodiment 3 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
20 parts of Rhizoma Dryopteris Crassirhizomatiss, 15 parts of Pericarpium Granatis, 15 parts of Radix Dichroaes, 8 parts of Radix Sophorae Flavescentiss, 10 parts of Herba Cirsiis
(2) with claim in the step (1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours earlier after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into the thick paste shape; Filtering residue reuse water extraction 2 times extracted 2.5 hours for the first time, extracted 1.5 hours for the second time, filtered, and merging filtrate also is condensed into the thick paste shape; Merge extractum, add appropriate amount of starch and dextrin (or other adjuvant) at last, mix homogeneously, oven dry is pulverized, and promptly is prepared into powder (every 1g is equivalent to crude drug in whole 1g).
(3) drug use method of the present invention: coccidiosis, mixed feeding: poultry, fowl, every 1kg feedstuff adds medicine 10g of the present invention, logotype 5-7 day.
Embodiment 4 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
Rhizoma Dryopteris Crassirhizomatis 25g, Pericarpium Granati 20g, Radix Dichroae 15g, Radix Sophorae Flavescentis 10g, Herba Cirsii 10g
(2) with claim in the step (1) each weight proportion crude drug pulverize after, after water soaks 2 hours with medical material, decoct with high heat then to boiling, reuse slow fire boiling 30 minutes is filtered, filtering residue adds water with slow fire boiling twice, each 1 hour.Merging filtrate is concentrated into 80 milliliters with filtrate, and adding ethanol ethanol content to the filtrate is 70%, filters, and filtrate recycling ethanol is concentrated into every 1ml and is equivalent to crude drug in whole 2g, and filtration, embedding, sterilization promptly are prepared into oral liquid.
(3) drug use method of the present invention: coccidiosis, mix drink: poultry, fowl, every 1L water adds medicine 1.5ml of the present invention, freely drinks logotype 5-7 day.
Embodiment 5 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
Rhizoma Dryopteris Crassirhizomatis 20g, Pericarpium Granati 15g, Radix Dichroae 20g, Radix Sophorae Flavescentis 10g, Herba Cirsii 10g
(2) with claim in the step (1) each weight proportion crude drug pulverize after, after water soaks 1 hour with medical material, decoct with high heat then to boiling, reuse slow fire boiling 30 minutes is filtered, filtering residue was with slow fire boiling twice, each 1 hour.Merging filtrate is concentrated into 75 milliliters with filtrate, and adding ethanol ethanol content to the filtrate is 70%, filters, and filtrate recycling ethanol is concentrated into every 1ml and is equivalent to crude drug in whole 1g, and cold preservation, filtration, fine straining, embedding, sterilization promptly are prepared into injection.
(3) drug use method of the present invention: coccidiosis, intramuscular injection, each every 1kg body weight, sheep, pig 0.1-0.2ml/kg, dog, rabbit 0.2ml, 2 times on the one, logotype 3-5 day.
Embodiment 6 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
Rhizoma Dryopteris Crassirhizomatis 20g, Pericarpium Granati 20g part, Radix Dichroae 10g part, Radix Sophorae Flavescentis 5g, Herba Cirsii 15g
(2) with claim in the step (1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours earlier after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into extractum; Filtering residue reuse water extraction 2 times extracted 2.5 hours for the first time, extracted 1.5 hours for the second time, filter, merging filtrate also is condensed into extractum, adds appropriate amount of starch, magnesium stearate at last, granulation, tabletting, every 0.2g (every 1g is equivalent to crude drug in whole 2g) promptly is prepared into tablet.
(3) drug use method of the present invention: coccidiosis, dog, every day the 2-4 sheet, rabbit, fowl 1-2 sheet, logotype 7 days.
For showing the prevention effect of medicine of the present invention to coccidiosis, medicine of the present invention is carried out the clinical observation on the therapeutic effect test, below further set forth the beneficial effect of medicine of the present invention by testing example.
Test example 1
In July, 2008,, carry out the clinical efficacy test of medicine of the present invention in big northern agricultural group animal health Technical Research Center experimental animal room for observing the prevention effect of Chinese medicine of the present invention to coccidiosis.Buy 210 of 1 age in days Luo Man chickens back from Beijing's Miyun County tack kind chicken house, raise in the hen house of strict sterilization, feed, freely drink water with the standard compliant feedstuff that does not contain coccidiostat of autogamy.When brooding to 16 ages in days, at random 210 chickling are divided into 7 groups, 30 every group for examination.
Test grouping and administration: test is divided into 7 groups, and the blank group does not infect not administration; Infect the matched group not administration of falling ill; Chinese medicine of the present invention adopts embodiment 1 preparation for 1 group, the mixed feeding administration, and the per kilogram feedstuff adds Chinese medicine 10g of the present invention; Chinese medicine of the present invention adopts embodiment 2 preparations for 2 groups, mixes the drink administration, and every 1L water adds Chinese medicine 1.5g of the present invention, freely drinks; Chinese medicine of the present invention adopts embodiment 3 preparations for 3 groups, the mixed feeding administration, and the per kilogram feedstuff adds Chinese medicine 10g of the present invention; Chinese medicine of the present invention adopts embodiment 4 preparations for 4 groups, mixes the drink administration, and every 1L water adds Chinese medicine 1.5ml of the present invention, freely drinks; The diclazuril group adopts 0.5% diclazuril pre-mixing agent (autogamy), and per 1 kilogram of feed is added 0.2g diclazuril pre-mixing agent, mixed feeding administration; Except that the blank group with infect the matched group, all the other are respectively organized and begin administration, logotype 7 days 18 ages.
Test is with coccidian oocyst and infection method: test is provided by animal medicine institute of Chinese agricultural university parasitic disease laboratory with Eimeria tenella spore egg capsule, after toxicity test, by 10 * 10
4Individual/only contamination.Except that the blank group, during 20 ages in days, to the artificial oral vaccination contamination of chicken.
Process of the test: after the contamination in 20 ages, observed 7 record chicken spirit, appetite, feces situation continuously.During 28 ages in days, all heavy, cut open and kill, observe caecum lesion, calculate the egg sac number (OPG) of cecal content with the Maxwell method, calculate the egg capsule value by field, angle therapy for clearing away heat.Estimate according to indexs such as survival rate, the relative weight gain rate, pathological changes value, anticoccidial index (ACI), egg capsule values and respectively to organize curative effect of medication.The results are shown in Table 1.
Table 1 medicine of the present invention is added up the chickens infected with eimeria curative effect
Result of the test shows: and 4 groups of Chinese medicine of the present invention (1 group-powder, 2 groups-granule, 3 groups-powder, 4 groups-oral liquid) good palatability, have no side effect and untoward reaction, slightly better to the treating and preventing coccidiosis of chicken effect than diclazuril pre-mixing agent.4 groups of Chinese medicine of the present invention anticoccidial index is all greater than 180, and it is outstanding to belong to curative effect, and 4 groups of (oral liquid group) effects of Chinese medicine wherein of the present invention are best.
Test example 2
In August, 2008, on the occasion of high temperature season, certain pig farm, Xiangtan County, Hunan Chen 2 nest piglets, 13 ages in days, suffer from diarrhoea, arrange the white milk cream shape just, raiseeing main Chen doubtful is antibacterial or viral infection, use vibramycin injection to add the astragalin injection joint injection, the commentaries on classics of not getting better on the 3rd, the state of an illness increases the weight of.It is relatively poor to observe its piglet body condition, and fur is coarse, and doubting is coccidium infection, gets stool examination, finds egg capsule, is diagnosed as the pig coccidiosis.Use embodiment 5 preparations medicine of the present invention, adopt administered intramuscular, every piglets is injected medicine 1ml of the present invention, logotype 5 days every day.The 3rd, most of sick pig stopped diarrhoea, and sick swinery was almost recovered on 1.
Test example 3
In July, 2009, certain yellow Labrador Retriever of supporting, 2 monthly ages are contained in distinguished personages garden, Tiantong Yuan, ChangPing, Beijing City district, about 5.8 kilograms of body weight, loss of appetite, dyspepsia, diarrhoea, feces are thin, and the dog master goes to pet clinic to open oral antibiotic, use a week, the state of an illness commentaries on classics of not getting better.The observation dog becomes thin, feces has been brown, get stool examination, finds egg capsule, is diagnosed as the dog coccidiosis.Adopt embodiment 6 preparations medicine of the present invention, for oral administration, 4 of every days, while oral glucose water, logotype 7 days.The 3rd day, sick dog spirit took a turn for the better, and the 5th day, sick dog stopped diarrhoea.After 10 days, sick dog spirit appetite recovers normal fully.
Claims (7)
1. Chinese medicine for the treatment of coccidiosis, it is characterized in that ingredient is made up of Rhizoma Dryopteris Crassirhizomatis, Pericarpium Granati, Radix Dichroae, Radix Sophorae Flavescentis and Herba Cirsii, the weight proportion of mentioned component is as follows: Rhizoma Dryopteris Crassirhizomatis 2-25 part, Pericarpium Granati 5-20 part, Radix Dichroae 5-20 part, Radix Sophorae Flavescentis 3-15 part, Herba Cirsii 5-15 part.
2. the Chinese medicine of treatment coccidiosis according to claim 1 is characterized in that the weight proportion of mentioned component is as follows: Rhizoma Dryopteris Crassirhizomatis 15-22 part, Pericarpium Granati 10-18 part, Radix Dichroae 10-18 part, Radix Sophorae Flavescentis 6-10 part, Herba Cirsii 6-12 part.
3. the Chinese medicine of treatment coccidiosis according to claim 2 is characterized in that the weight proportion of mentioned component is as follows: 20 parts of Rhizoma Dryopteris Crassirhizomatiss, 15 parts of Pericarpium Granatis, 15 parts of Radix Dichroaes, 8 parts of Radix Sophorae Flavescentiss, 10 parts of Herba Cirsiis.
4. preparation method of Chinese medicine as each described treatment coccidiosis of claim 1-3, it comprises the steps:
(1) takes by weighing each medicine material by weight ratio;
(2) each medicine material is pulverized and sieved back or each raw material after water or alcohol extraction, concentrating, add adjuvant or complementary composition commonly used in the pharmacy, be prepared from.
5. the preparation method of Chinese medicine of treatment coccidiosis according to claim 4 is characterized in that the dosage form that makes is: powder, powder, tablet, granule, oral liquid or injection.
6. the Chinese medicine of each described treatment coccidiosis of claim 1-3 is in the application that is used to prepare aspect the treatment coccidiosis medicine.
7. the Chinese medicine of each described treatment coccidiosis of claim 1-3 is in the application that is used to prepare aspect the treatment coccidiosis of domestic fowls medicine.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103250914B (en) * | 2013-06-08 | 2014-03-12 | 潘李亮 | Special feed additive for grown-up rex rabbits at age of above 90 days |
| CN104435023B (en) * | 2014-12-09 | 2018-02-02 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Chinese medical extract and its application |
| CN104644803A (en) * | 2015-01-16 | 2015-05-27 | 沈阳伟嘉牧业技术有限公司 | Preparation method of poultry anticoccidia traditional Chinese medicine oral liquid |
| CN104623012A (en) * | 2015-03-13 | 2015-05-20 | 石家庄九鼎动物药业有限公司 | Formula of traditional Chinese medicine for treating coccidiosis in chicken and preparation method of oral solution of traditional Chinese medicine |
| CN105106484A (en) * | 2015-09-25 | 2015-12-02 | 全椒县大地种植专业合作社 | Medicine for treating sheep flock coccidiosis |
| CN109588555A (en) * | 2018-12-26 | 2019-04-09 | 北京爱绿生物科技有限公司 | A kind of water-soluble natural plants anticoccidial feed addictive and preparation method thereof |
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Effective date of registration: 20210722 Address after: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee after: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee after: BEIJING DABEINONG TECHNOLOGY GROUP Co.,Ltd. Patentee after: BEIJING VETERINARY DRUG SUPERVISION INSTITUTE Address before: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee before: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee before: BEIJING DABEINONG TECHNOLOGY GROUP Co.,Ltd. |
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Effective date of registration: 20210915 Address after: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee after: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee after: BEIJING DABEINONG TECHNOLOGY GROUP Co.,Ltd. Address before: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee before: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee before: BEIJING DABEINONG TECHNOLOGY GROUP Co.,Ltd. Patentee before: BEIJING VETERINARY DRUG SUPERVISION INSTITUTE |
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Effective date of registration: 20220705 Address after: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee after: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Address before: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee before: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee before: Beijing Da Bei agricultural science and technology group Limited by Share Ltd |
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