CN102309643A - Chinese medicine composition for treating chicken coccidiosis - Google Patents
Chinese medicine composition for treating chicken coccidiosis Download PDFInfo
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- CN102309643A CN102309643A CN201110281138A CN201110281138A CN102309643A CN 102309643 A CN102309643 A CN 102309643A CN 201110281138 A CN201110281138 A CN 201110281138A CN 201110281138 A CN201110281138 A CN 201110281138A CN 102309643 A CN102309643 A CN 102309643A
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Abstract
The invention provides a Chinese medicine composition for treating chicken coccidiosis, comprising the following ingredients: 15-25 weight portions of betel nut, 10-20 weight portions of cortex ailanthi, 10-20 weight portions of dandelion, 5-15 weight portions of Chinese knotweed herb, 5-15 weight portions of bighead atractylodes rhizome, and 1-10 weight portions of hairyvein agrimony. The Chinese medicine composition has the effects of removing dampness, destroying parasite, clearing heat, removing toxin, nourishing vital energy, curing diarrhea, and stopping bleeding, and has good efficacy of treating coccidiosis. The anticoccidial index is more than 170. The Chinese medicine composition has no toxic and side effect, little drug-resistant and drug residues, and no pollution, and has definite therapeutic effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that is used to treat chicken coccidiosis, belong to the herbal medicine technical field.
Technical background
Chicken coccidiosis mainly is to parasitize caused a kind of protozoacide in the Intestinum Gallus domesticus tract epithelial cell by a kind of or several the unicellular parasitic protozoas in sporozoa, Amy otology, the Eimeria coccidiosis.This disease is to propagate through coccidian oocyst, and chicken eats the spore egg capsule and infects, and infects the back chicken and shows weak and spiritual depressedly, likes that crowded wing is sagging together, and feather is loose random, and it is drowsiness to close one's eyes, and sick chicken is dysentery usually, and with blood, even symptom such as hemafecia.Above 3 monthly ages of main harm 10 ages in days are with interior chicken crowd, the especially the easiest generation of 15-45 age in days, and sickness rate 50%-70%, case fatality rate 20%-30%, severe patient can reach 80%.This disease except that causing the dead direct economic loss of chicken, also cause price of deed reduction, hypoevolutism, lose weight, lay eggs reduce and carcase quality under the degradation indirect loss.The expenses for prevention and control that China is used for chicken coccidiosis accounts for 1/3 of the whole expensess for prevention and control of chicken, and chicken coccidiosis is classified as one of five the most serious big diseases of birds harm by United States Department of Agriculture (USDA), and China also classifies it as two types of animal epidemics sick kind.
From the forties in 20th century; The topmost means of prevention of chicken coccidiosis is to use antibiotic and chemical synthetic drug; This measure has obtained certain prevention effect, but problems such as its drug resistance, drug residue, toxic and side effects and environmental pollution are following, are difficult to effective solution so far.In recent years; There is the measure of controlling chicken coccidiosis with vaccine prevention to propose in succession again; And developed several coccidiosis vaccines at present, and put on market, but clinical effectiveness is not very good; Main cause is all to have some problems at aspects such as the stability of the antigenicity of immune programme for children, immune detection, worm strain and vaccine, dosage form, methods for using, and aspect the postvaccinal environment control of coccidial vaccine, also has a series of problems.Therefore, press for clinically the development and develop a kind of difficult generation drug resistance, toxic and side effects is little and free of contamination anti-chicken coccidiosis medicine.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition that is used to treat chicken coccidiosis.It is the pure Chinese medicine composition that a kind ofly has no side effect, is difficult for producing drug resistance and drug residue, pollution-free and determined curative effect.
The objective of the invention is to realize through following technical scheme:
The present invention provides a kind of Chinese medicine composition that is used to treat chicken coccidiosis, and this Chinese medicine composition contains Semen Arecae, Cortex Ailanthi, Herba Taraxaci, Herb Polygoni Chinensis, the Rhizoma Atractylodis Macrocephalae and Herba Agrimoniae.
Wherein, the weight proportion of mentioned component is following: Semen Arecae 15-25 part, Cortex Ailanthi 10-20 part, Herba Taraxaci 10-20 part, Herb Polygoni Chinensis 5-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Herba Agrimoniae 1-10 part.
A kind of Chinese medicine composition that is used to treat chicken coccidiosis of the present invention, its preparation method is: take by weighing above-mentioned all medicines according to weight proportion, add 10 times of water gagings and decoct twice; Each 1.5-2 hour, filter merging filtrate; Filtrating is concentrated into 1ml and is equivalent to crude drug 1g, adds an amount of antiseptic, mixing; Sterilization, fill promptly gets.
Wherein, the method for using and the consumption of the Chinese medicine composition that said method makes are: chicken, mix drink, and per 1 premium on currency is converted these article 2ml, continuous use 3-5 days.
Method for using of the present invention and consumption are to control principle according to the dialectical opinion of Chinese veterinarian's prescription, confirm through a large amount of practices are final repeatedly.
The foundation that prescription of the present invention is selected is: theoretical according to Chinese veterinarian, chicken coccidiosis belongs to the malnutrition due to parasitic infestation category, is the heat syndrome of one type of the disease appearing in blood system due to the diseases caused by exogenous pathogenic factor worm heresy.Pathogenic heat focus on hematozemia and moving blood at blood system.Hematozemia causes that then essence and blood body fluid is consumed, and it is hemorrhage that moving blood mainly shows as the absurd row of heat in blood forcing blood, the bright exhaustion of YIN of the weary heat that exhausts of Jin Shui etc.Because of the evil impairment of blood and body fluid of worm, and retention of damp-heat in the interior is prone to be stranded spleen, so be main with removing dampness and killing parasites, heat-clearing and toxic substances removing more than the rule of treatment, is aided with invigorating the spleen and replenishing QI, hemostasis and dysentery-stopping.So it is monarch drug that we select Semen Arecae for use, its bitter in the mouth, suffering are warm in nature.Has parasite killing, removing food stagnancy, circulation of qi promoting, diuretic, the effect of preventing the attack (or recurrence) of malaria; Be aided with Cortex Ailanthi, Herba Taraxaci, heat clearing and damp drying, detoxifcation, the astringing intestine to stop diarrhea hemostasis, dispersing swelling and dissipating binds, the merit of principal drug assistance is brought into play the effect of removing dampness and killing parasites, heat-clearing and toxic substances removing jointly; Be adjuvant drug with Herb Polygoni Chinensis, the Rhizoma Atractylodis Macrocephalae again, be intended to clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, invigorating the spleen and benefiting QI; Be again messenger drug with the Herba Agrimoniae, astringing to arrest bleeding, dysentery relieving relax hemorrhage, dysentery that coccidiosis causes.At the medicine compatibility, play the merit of removing dampness and killing parasites, heat-clearing and toxic substances removing, invigorating the spleen and replenishing QI, dysentery relieving hemostasis altogether.So chicken coccidiosis is had good therapeutic efficiency.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1: a kind of Chinese medicine composition that is used to treat chicken coccidiosis, it is formed by weight being expressed as: 15 parts of Semen Arecaes, 10 parts of Cortex Ailanthis, 10 parts of Herba Taraxacis, 5 parts of Herb Polygoni Chinensiss, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 1 part of Herba Agrimoniae.Above-mentioned all medicines are taken by weighing raw material according to weight ratio, add 10 times of water gagings and decoct twice, each 1.5-2 hour, filter; Merging filtrate, filtrating is concentrated into 1ml and is equivalent to crude drug 1g, adds an amount of antiseptic, mixing; Sterilization, fill can make the medicine of present embodiment.
Embodiment 2: a kind of Chinese medicine composition that is used to treat chicken coccidiosis, it is formed by weight being expressed as: 25 parts of Semen Arecaes, 20 parts of Cortex Ailanthis, 20 parts of Herba Taraxacis, 15 parts of Herb Polygoni Chinensiss, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Herba Agrimoniaes.Above-mentioned all medicines are taken by weighing raw material according to weight ratio, add 10 times of water gagings and decoct twice, each 1.5-2 hour, filter; Merging filtrate, filtrating is concentrated into 1ml and is equivalent to crude drug 1g, adds an amount of antiseptic, mixing; Sterilization, fill can make the medicine of present embodiment.
Embodiment 3: a kind of Chinese medicine composition that is used to treat chicken coccidiosis, it is formed by weight being expressed as: 20 parts of Semen Arecaes, 15 parts of Cortex Ailanthis, 15 parts of Herba Taraxacis, 10 parts of Herb Polygoni Chinensiss, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Herba Agrimoniaes.Above-mentioned all medicines are taken by weighing raw material according to weight ratio, add 10 times of water gagings and decoct twice, each 1.5-2 hour, filter; Merging filtrate, filtrating is concentrated into 1ml and is equivalent to crude drug 1g, adds an amount of antiseptic, mixing; Sterilization, fill can make the medicine of present embodiment.
Embodiment 4: a kind of Chinese medicine composition that is used to treat chicken coccidiosis, it is formed by weight being expressed as: 18 parts of Semen Arecaes, 14 parts of Cortex Ailanthis, 14 parts of Herba Taraxacis, 8 parts of Herb Polygoni Chinensiss, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of Herba Agrimoniaes.Above-mentioned all medicines are taken by weighing raw material according to weight ratio, add 10 times of water gagings and decoct twice, each 1.5-2 hour, filter; Merging filtrate, filtrating is concentrated into 1ml and is equivalent to crude drug 1g, adds an amount of antiseptic, mixing; Sterilization, fill can make the medicine of present embodiment.
Chinese medicine composition of the present invention is to the test report of chicken coccidiosis therapeutic effect:
1 materials and methods
1.1 test material
1.1.1 trial drug supplies the examination Chinese medicine composition by embodiment 1,2,3,4 (the 1ml medicinal liquid is equivalent to the 1g raw medicinal herbs) to be provided respectively.Sulphadimidine sodium, Huangyan, Zhejiang animal pharmaceutical factory produces.
1.1.2 170 of experimental animal 1 Japanese instar chicklings are purchased in Shijiazhuang gold plumage chicken house for generations.Under the strict sterilization environment, raise and continuous 2d excrement inspection non-ball worm egg capsule, raise subsequent use to 14 ages in days.
1.1.3 test provides with coccidian oocyst Eimeria tenella ovum, conventional reagent effluent north agriculture university parasite laboratory.Artificial challenge's non-ball worm chicken subculture is 1 time before the test, obtains test and uses egg capsule, 29 ℃ of sporeizations, 4 ℃ of preservations.
1.2 test method
During 14 ages in days, choose body weight close (body weight differs and is no more than 5g), and confirm as 140 of healthy chickling, be divided into 7 groups at random, 20 every group through the expection observation.I group is blank group (do not infect, not medication); II organizes positive matched group; (infection, not medication), the III group is medicine matched group, sulphadimidine sodium group; IV, V, VI, VII group are respectively test group (embodiment 1,2,3,4), convert water 1L by 2ml medicinal liquid (the 1ml medicinal liquid is equivalent to the 1g raw medicinal herbs) and supply the chicken crowd freely to drink.Each medication group was added corresponding medicine the same day of dividing into groups in feedstuff or drinking-water, take 5d continuously.Except that the blank group, other the 5 groups of tender Amy ear of the equal per oral inoculation of test chicken spore egg capsule suspensions (contain spore egg capsule 8.0 * 10
4Individual/only), isolated rearing under the same terms.Infect back checkout facility chicken essence god every day, appetite, the feces promoting the circulation of blood of going forward side by side and just keep the score, 8d after the administration begins to weigh, and calculates survival rate, rate of body weight gain that each is organized; And chicken all slaughtered cut open inspection, observe and carry out caecum lesion and keep the score.Hemafecia is kept the score; Calculate caecum egg sac number, egg capsule than number, egg capsule value and anticoccidial index (ACI).
1.3 evaluating drug effect index
1.3.1 survival rate:
Survival rate (%)=(test chicken sum in group internal memory live chickens number/group) * 100%
1.3.2 the relative weight gain rate:
The relative weight gain rate (%)=(average weight gain of the average weight gain of each infected group/blank group) * 100%
1.3.3 feces is kept the score: with reference to the standard of Morehouse, promptly 4d begins to observe the blood stool situation behind the artificial challenge, keeps the score by the hemafecia order of severity.
1.3.4 caecum lesion is kept the score: the standard of keeping the score with reference to Johnson and Reid etc. is kept the score to caecum lesion.Keep the score according to caecum lesion, calculate complete group of average lesion score, obtain the pathological changes value then.The average lesion score of full group=organize lesion score summation/full group entirely to observe the chicken number: pathological changes value=organize entirely average lesion score * 10.
1.3.5 egg capsule value: after the off-test, slaughter whole chickens, cut off caecum, scrape and get content, egg capsule 1,000,000 numbers in every caecum homogenate are calculated in homogenate, draw the egg capsule value.Egg capsule 1,000,000 numbers are less than 0.1 in every caecum homogenate, and the egg capsule value is 0; Egg capsule 1,000,000 numbers are 0.1-1.0 in every caecum homogenate, and the egg capsule value is 1; Egg capsule 1,000,000 numbers are 1.1-1.9 in every caecum homogenate, and the egg capsule value is 10; Egg capsule 1,000,000 numbers are 2.0-5.9 in every caecum homogenate, and the egg capsule value is 20; Egg capsule 1,000,000 numbers are 6.0-10.9 in every caecum homogenate, and the egg capsule value is 30; Egg capsule 1,000,000 numbers are greater than 11.0 in every caecum homogenate, and the egg capsule value is 40.
1.3.6 anticoccidial index:
Calculate ACI=(the relative weight gain rate+survival rate)-(pathological changes value+egg capsule value) according to anticoccidial index (ACI) method
1.4 evaluation of result
Judge the effect of anticoccidial: ACI＞180 according to ACI, anticoccidial is efficient: ACI is 160-180, imitates in the anticoccidial; ACI is 120-160, the anticoccidial poor efficiency; ACI＜120, anticoccidial is invalid.
2 results
2.1 incidence and symptom
The blank group is searched for food, drinking-water, defecation and mental status no abnormality seen, in feces, does not detect coccidian oocyst during off-test.The positive controls chicken is 3d behind the inoculating spores egg capsule, and it is dull spirit to occur, and the feather pine disorderly, and is drowsiness, and feed intake reduces.4d begins to occur hemafecia, and 5d occurs dead, dead 7 altogether at 5,6 days.The chicken that dies of illness cut open the inspection see the obvious enlargement of caecum, be kermesinus, in be full of blood, blood clotting is fast, the intestinal wall attenuation, a large amount of petechial hemorrhages appear in intestinal mucosa.
Medicine matched group and test group a small amount of hemafecia occurs at 5d, and hemafecia disappears behind 5d, more than each group chicken death does not appear.
2.2 curative effect of medication result
Results such as the survival rate of each group, the relative weight gain rate, pathological changes value see table 1.
Table 1 Chinese medicine composition is to the curative effect of artificial infection chicken's eimeria coccidiosis
The result: test group (embodiment 1,2,3,4) ACI value is respectively 178.6,180.0,177.7,176.8, and for imitating in the anticoccidial, wherein index is 180 in 2 groups of anti-balls of embodiment, and is efficient near anticoccidial; Medicine control group A CI value is 163.2, and is suitable with the test group effect.This result of the test shows that test group all can be prevented and treated the Eimeria Tenella disease well, can prevent that rate of body weight gain from reducing, and rate of body weight gain is approaching, all is higher than the medicine matched group.Therefore, behind the test group continuous use 3d to treatment artificial infection chicken eimeria coccidiosis have ACI height, gaining effect good, suppress the effect that egg capsule produces.
3 conclusions
This test confirms that omnidistance drinking-water adds 2ml/L should invent product, can effectively treat chicken coccidiosis, and its anticoccidial index is more than 170.
According to this experimental result, recommend administering mode to be: chicken, mix drink, per 1 premium on currency is converted these article 2ml, continuous use 5 days.
Claims (1)
1. Chinese medicine composition of treating chicken coccidiosis; It is characterized in that said Chinese medicine composition comprises the component of following weight proportion: Semen Arecae 15-25 part, Cortex Ailanthi 10-20 part, Herba Taraxaci 10-20 part, Herb Polygoni Chinensis 5-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Herba Agrimoniae 1-10 part.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103989868A (en) * | 2014-05-26 | 2014-08-20 | 湖州天健兽药有限公司 | Traditional Chinese medicine veterinary drug for preventing silky fowl coccidiosis |
| CN108066461A (en) * | 2017-12-08 | 2018-05-25 | 重庆乾富科技有限公司 | A kind of method for treating a heterakidosis of chicken |
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| CN101129673A (en) * | 2007-08-17 | 2008-02-27 | 李培英 | Pure traditional Chinese medicine formulated product for preventing and treating coccidiosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101129673A (en) * | 2007-08-17 | 2008-02-27 | 李培英 | Pure traditional Chinese medicine formulated product for preventing and treating coccidiosis |
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| 万懿等: "中草药防治鸡球虫病", 《养殖技术顾问》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989868A (en) * | 2014-05-26 | 2014-08-20 | 湖州天健兽药有限公司 | Traditional Chinese medicine veterinary drug for preventing silky fowl coccidiosis |
| CN108066461A (en) * | 2017-12-08 | 2018-05-25 | 重庆乾富科技有限公司 | A kind of method for treating a heterakidosis of chicken |
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Application publication date: 20120111 |