CN101209296A - Chinese medicinal granule with worm-expelling liver-caring, hemostasis and dysentery-stopping efficacy - Google Patents
Chinese medicinal granule with worm-expelling liver-caring, hemostasis and dysentery-stopping efficacy Download PDFInfo
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- CN101209296A CN101209296A CNA2006101305430A CN200610130543A CN101209296A CN 101209296 A CN101209296 A CN 101209296A CN A2006101305430 A CNA2006101305430 A CN A2006101305430A CN 200610130543 A CN200610130543 A CN 200610130543A CN 101209296 A CN101209296 A CN 101209296A
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Abstract
The invention relates to a Chinese traditional medicine granule with the efficacies of expelling worms, protecting the liver and stopping bleeding and dysentery, including ten Chinese traditional medicines of southernwood, agrimony, dichroa febrifuga, garden burnet root, pulsatilla chinensis, golden buckwheat rhizome, thistle, white paeony root, radix astragali and liquorice. The invention is mainly used for treating the symptoms of intestinal tract bleeding, intestinal wall thickening and necrosis and intestinal mucosa shedding, etc. caused by chicken eimeria maxima, eimeria acervulina, eimeria necatrix and so on. The invention can alleviated the symptoms of dull standing, aphagia or anorexia, defecating bloody stool or whole blood, emaciation and poor growth of sick chickens caused by coccidiosis. The invention has the efficacies of expelling worms, protecting the liver and stopping bleeding and dysentery. By considering the short avian genital tract and the special physiological structure of inability to digest lignocellulose, the medicine is prepared into soluble granules which can quickly be dissolved into drinking water which is absorbed by sick chickens so as to achieve the purpose of quick effect.
Description
Technical field
The invention belongs to field of veterinary, particularly relate to a kind of Chinese medicine granules with worm-expelling and liver-protecting, hemostasis and dysentery-stopping efficacy.
Background technology
Coccidiosis is to parasitize the intracellular parasite of poultry, is one of disease of serious harm aquaculture, brings serious economy loss to aquaculture.Though at present domestic existing many be used for the treatment of coccidiosis in, western drug, but the Western medicine side effect is big, easily cause the livestock products veterinary drug residue to exceed standard, easily produce drug resistance, therefore not only need certain off-drug period to guarantee the safety of livestock products after using Western medicine to the mankind, and influence the livestock products outlet of China, cause Western medicine to be very restricted in the use of outlet group.
Shortcomings such as the Chinese medicine preparation that uses clinically mostly is powder at present, and administration inconvenience is short because of the digestive tract of chicken again, can not digest lignocellulose, and the drug absorption that causes is poor, and consumption is big.
Summary of the invention
Based on above-mentioned situation, the present invention aims to provide a kind of Chinese medicine granules with worm-expelling and liver-protecting, hemostasis and dysentery-stopping efficacy.
The object of the present invention is achieved like this: a kind of Chinese medicine preparation with worm-expelling and liver-protecting, hemostasis and dysentery-stopping efficacy, it is characterized in that: Herba Artemisiae Annuae 3-6 part, Herba Agrimoniae 2-4 part, Radix Dichroae 1-2 part, Radix Sanguisorbae 1-2 part, Radix Pulsatillae 1-3 part, Rhizoma Fagopyri Dibotryis 1-3 part, Radix Cirsii Japonici 1-2 part, Radix Paeoniae Alba 1-2 part, Radix Astragali 1-2 part, Radix Glycyrrhizae 1-2 part.
Be preferably: 4 parts of Herba Artemisiae Annuaes, 3 parts of Herba Agrimoniaes, 1 part of Radix Dichroae, 1 part of Radix Sanguisorbae, 1 part of the Radix Pulsatillae, 2 parts of Rhizoma Fagopyri Dibotryiss, 1 part of Radix Cirsii Japonici, 1 part of the Radix Paeoniae Alba, 2 parts of the Radixs Astragali, 1 part in Radix Glycyrrhizae.
A kind of Chinese medicine preparation with worm-expelling and liver-protecting, hemostasis and dysentery-stopping efficacy is characterized in that: the dosage form of described Chinese medicine preparation is a granule.
We utilize Chinese veterinarian's theory " dialectics " for adopting the medicine commonly used of the man avian coccidium infection of treatment, according to the principles of formulating prescriptions of " main and auxiliary, help, make ", treat tame avian coccidium infection by approach such as worm-expelling and liver-protecting, hemostasis and dysentery-stoppings.Herba Artemisiae Annuae clearing away summer-heat in the side,, Radix Dichroae inhibited to the Eimeria coccidiosis also have very strong anticoccidial effect except that having refrigeration function, two medicines share and can strengthen the anticoccidial effect, are principal agent; Be aided with the Radix Pulsatillae, Rhizoma Fagopyri Dibotryis heat-clearing and toxic substances removing, removing heat from blood, anthelmintic; Assistant is with Herba Agrimoniae, Radix Sanguisorbae, Radix Cirsii Japonici hemostasis, spleen invigorating, and the Radix Paeoniae Alba is enriched blood, Radix Astragali invigorating the spleen and replenishing QI, build up resistance; Radix Glycyrrhizae invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription are messenger drug.Each medicine share, and is the good recipe of treatment coccidiosis.
The present invention adopts the industry method in common to make: above ten flavor medical materials, decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, filter, the filtrate decompression thin film evaporation, filtrate is concentrated into the clear paste that relative density is 1.29-1.31 (85 ℃), adding adjuvant granulates, the dry shaping of wet grain, packing, promptly.
Below with concrete description of test effect of the present invention:
1 materials and methods
1.1 trial drug
Medicine main component of the present invention is Herba Artemisiae Annuae, Herba Agrimoniae, Radix Dichroae, Radix Sanguisorbae, the Radix Pulsatillae, Rhizoma Fagopyri Dibotryis, Radix Cirsii Japonici, the Radix Paeoniae Alba, the Radix Astragali, Radix Glycyrrhizae, and recommended dose 1/1000 is mixed drink.Control drug: the amprolium hydrochloride raw material, available from Chongqing drugmaker, lot number 2000092101 faces with the preparation of before making 6%.
1.2 laboratory animal
350 AA broiler, available from the Nanjing company of raising chickens, be divided into seven groups at random, be respectively medicine high dose group of the present invention, dosage group in the medicine of the present invention, medicine low dose group of the present invention, amprolium hydrochloride preparation group, negative control group (group is not treated in morbidity), positive controls (do not fall ill and do not treat group), safe matched group (according to 10 times of administration groups of recommended dose), 50 every group.Go out to be transported in this laboratory pouity dwelling place behind the shell and raise in cages, Routine Management is fed to complete feed to 15 age in days, is for experiment after excrement is examined the non-ball worm egg capsule.
1.3 artificial challenge
Except that positive controls and safe matched group, every plumage chicken gavages 100,000 spore Eimeria tenella egg capsules.
1.4 medication
It is soluble in water that every group of medicine pressed doses, allows chicken freely drink water.Administration when infecting, logotype 6 days.
1.5 the result judges
Observe chicken manure after the medication and just reach clinical symptoms.Weighing to cut open and kill in the infection back on the 6th day, observes intestinal (small intestinal, caecum) pathological changes, carries out caecum egg capsule counting with Maxwell egg count method.
1.5.1 the average weight before the average weight-on-test during average weight gain average weight gain=off-test.
1.5.2 the relative weight gain rate the relative weight gain rate=(each medication group or negative control group average weight gain/positive controls average weight gain) * 100%
1.5.3 survival rate survival rate=(the chicken number during survival chicken number/on-test) * 100%
1.5.4 lesion score is kept the score according to the order of severity of cuing open inspection rear intestinal pathological changes.No pathological changes is kept the score and is "-"; Slight lesion score is "+"; The caecum wall thickening has to be " ++ " to medium hemorrhage keeping the score for a short time; In have a lot of clots to keep the score to be " +++"; Keep the score because of coccidiosis death and to be " ++ ++ ".
1.5.5 the pathological changes value is kept the score according to the order of severity of cuing open inspection rear intestinal pathological changes.With reference to the standard of Merck Sharp, i.e. the average of the lesion score of every group of experimental chicken * 10
1.5.6 hemafecia is kept the score with reference to Morehouse and Baron standard, promptly 5d begins to observe the blood stool situation behind the artificial challenge, and continuously 5d keeps the score, and do complete group average.
1.5.7 the egg capsule value is according to the O.P.G value, tabling look-up draws.
1.5.7 the anticoccidial index is according to the computing formula of Merck (Merck) company, ACI=(the relative weight gain rate+survival rate)-(pathological changes value+egg capsule value) obtained.
1.6 test grouping and processing
See Table 1
Table 1 divides into groups and handles as shown in the table
2 result of the tests
Result of the test sees Table 2 in detail.
Table 2 medicine of the present invention is to chicken coccidiosis result of the test table
Result by above test shows that the anticoccidial index of medicine various dose group of the present invention (basic, normal, high) is respectively 187,197 and 198.2, and middle and high dosage group belongs to the anticoccidial high efficiency levels, and low dose group also is in the effective range of anticoccidial; Amprolium hydrochloride preparation group anticoccidial index is 163.1, has been lower than the effect level of anticoccidial.On rate of body weight gain, the middle and high dosage group of medicine of the present invention is the highest, can more effectively improve chicken group's rate of body weight gain than amprolium hydrochloride preparation group.In caecum lesion value and egg capsule value, the middle and high dosage group of medicine of the present invention is low than amprolium hydrochloride preparation group obviously.
3 conclusions
3.1 curative effect of medication of the present invention
Medicine of the present invention senior middle school dosage anticoccidial effect is all fine, and is more or less the same, and considers that dosage group in the medicine of the present invention is used in raiser's economic benefit suggestion.
3.2 safety testing
50 chickens carry out safety experiment, and behind the medicine of the present invention of the safe dose of feeding (10/1000 mixes drink), feed intake, amount of drinking water all do not have significant change, and chicken group spirit is good, proves that medicine of the present invention is a safety to chicken.
Beneficial effect of the present invention: prescription of the present invention has the effect of worm-expelling and liver-protecting, hemostasis and dysentery-stopping.In conjunction with birds reproductive tract weak point, can not digest the special physiological structure of wood fibre, medicine is made soluble granule, dissolving rapidly in feeding drinking-water after the trouble chicken passes through the drinking-water absorption, can reach the purpose of rapid onset.
The specific embodiment
Embodiment 1: 3 parts of Herba Artemisiae Annuaes, 2 parts of Herba Agrimoniaes, 1 part of Radix Dichroae, 1 part of Radix Sanguisorbae, 1 part of the Radix Pulsatillae, 1 part of Rhizoma Fagopyri Dibotryis, 1 part of Radix Cirsii Japonici, 1 part of the Radix Paeoniae Alba, 1 part of the Radix Astragali, 1 part in Radix Glycyrrhizae.The present invention adopts the industry method in common to make: above ten flavor medical materials, decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, filter, the filtrate decompression thin film evaporation, filtrate is concentrated into the clear paste that relative density is 1.29-1.31 (85 ℃), adding adjuvant granulates, the dry shaping of wet grain, packing, promptly.
Be mainly used to treat the huge eimeria tenella of chicken, heap type eimeria tenella, poison that intestinal bleeding, the intestinal wall that coccidium infections such as eimeria tenella cause thickens, downright bad, disease such as intestinal mucosa comes off.Can alleviate because of chicken that coccidiosis is caused a disease slow-witted upright, do not eat or lack eat, the drawstring bloody stool just or symptoms such as whole blood, sick chicken are become thin, undergrowth.Mix drink.Add this product 1 gram in per 1 premium on currency, a twice-daily is freely drunk, logotype 3-5 days.The serious symptom doubled amount is used.
Embodiment 2: 4 parts of Herba Artemisiae Annuaes, 3 parts of Herba Agrimoniaes, 1 part of Radix Dichroae, 1 part of Radix Sanguisorbae, 1 part of the Radix Pulsatillae, 2 parts of Rhizoma Fagopyri Dibotryiss, 1 part of Radix Cirsii Japonici, 1 part of the Radix Paeoniae Alba, 2 parts of the Radixs Astragali, 1 part in Radix Glycyrrhizae.The present invention adopts the industry method in common to make: above ten flavor medical materials, decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, filter, the filtrate decompression thin film evaporation, filtrate is concentrated into the clear paste that relative density is 1.29-1.31 (85 ℃), adding adjuvant granulates, the dry shaping of wet grain, packing, promptly.
Be mainly used to treat the huge eimeria tenella of chicken, heap type eimeria tenella, poison that intestinal bleeding, the intestinal wall that coccidium infections such as eimeria tenella cause thickens, downright bad, disease such as intestinal mucosa comes off.Can alleviate because of chicken that coccidiosis is caused a disease slow-witted upright, do not eat or lack eat, the drawstring bloody stool just or symptoms such as whole blood, sick chicken are become thin, undergrowth.Mix drink.Add this product 1 gram in per 1 premium on currency, a twice-daily is freely drunk, logotype 3-5 days.The serious symptom doubled amount is used.
Embodiment 3: 6 parts of Herba Artemisiae Annuaes, 4 parts of Herba Agrimoniaes, 2 parts of Radix Dichroaes, 2 parts of Radix Sanguisorbaes, 3 parts of the Radix Pulsatillaes, 3 parts of Rhizoma Fagopyri Dibotryiss, 2 parts of Radix Cirsii Japonicis, 2 parts of the Radix Paeoniae Albas, 2 parts of the Radixs Astragali, 2 parts in Radix Glycyrrhizae.The present invention adopts the industry method in common to make: above ten flavor medical materials, decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, filter, the filtrate decompression thin film evaporation, filtrate is concentrated into the clear paste that relative density is 1.29-1.31 (85 ℃), adding adjuvant granulates, the dry shaping of wet grain, packing, promptly.
Be mainly used to treat the huge eimeria tenella of chicken, heap type eimeria tenella, poison that intestinal bleeding, the intestinal wall that coccidium infections such as eimeria tenella cause thickens, downright bad, disease such as intestinal mucosa comes off.Can alleviate because of chicken that coccidiosis is caused a disease slow-witted upright, do not eat or lack eat, the drawstring bloody stool just or symptoms such as whole blood, sick chicken are become thin, undergrowth.Mix drink.Add this product 1 gram in per 1 premium on currency, a twice-daily is freely drunk, logotype 3-5 days.The serious symptom doubled amount is used.
Claims (3)
1. the Chinese medicine preparation with worm-expelling and liver-protecting, hemostasis and dysentery-stopping efficacy is characterized in that: Herba Artemisiae Annuae 3-6 part, Herba Agrimoniae 2-4 part, Radix Dichroae 1-2 part, Radix Sanguisorbae 1-2 part, Radix Pulsatillae 1-3 part, Rhizoma Fagopyri Dibotryis 1-3 part, Radix Cirsii Japonici 1-2 part, Radix Paeoniae Alba 1-2 part, Radix Astragali 1-2 part, Radix Glycyrrhizae 1-2 part.
2. a kind of Chinese medicine preparation with worm-expelling and liver-protecting, hemostasis and dysentery-stopping efficacy according to claim 1 is characterized in that optimizing prescriptions of the present invention is: 4 parts of Herba Artemisiae Annuaes, 3 parts of Herba Agrimoniaes, 1 part of Radix Dichroae, 1 part of Radix Sanguisorbae, 1 part of the Radix Pulsatillae, 2 parts of Rhizoma Fagopyri Dibotryiss, 1 part of Radix Cirsii Japonici, 1 part of the Radix Paeoniae Alba, 2 parts of the Radixs Astragali, 1 part in Radix Glycyrrhizae.
3. a kind of Chinese medicine preparation with worm-expelling and liver-protecting, hemostasis and dysentery-stopping efficacy according to claim 1 is characterized in that: the dosage form of described Chinese medicine preparation is a granule.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2006101305430A CN101209296A (en) | 2006-12-25 | 2006-12-25 | Chinese medicinal granule with worm-expelling liver-caring, hemostasis and dysentery-stopping efficacy |
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| CNA2006101305430A CN101209296A (en) | 2006-12-25 | 2006-12-25 | Chinese medicinal granule with worm-expelling liver-caring, hemostasis and dysentery-stopping efficacy |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552477A (en) * | 2010-12-09 | 2012-07-11 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition for treating chicken coccidiosis and preparation method thereof |
| CN102579697A (en) * | 2012-03-27 | 2012-07-18 | 贵州省畜牧兽医研究所 | Chinese herbal prescription for treating coccidiosis in chicken |
| CN103349718A (en) * | 2013-07-31 | 2013-10-16 | 华南农业大学 | Livestock and poultry cryptozoite infection prevention and treatment compound traditional Chinese medicine, preparation method and application thereof |
| CN103432441A (en) * | 2013-08-10 | 2013-12-11 | 安徽快康生物科技有限公司 | Traditional Chinese medicine composition for treating coccidiosis in chicken |
| CN104491070A (en) * | 2014-12-10 | 2015-04-08 | 遵义师范学院 | Traditional Chinese medicinal extract compound used for preventing and treating chicken coccocidiosis and production method thereof |
| CN106344883A (en) * | 2016-11-16 | 2017-01-25 | 山东恩康药业有限公司 | Pure traditional Chinese medicine composition for resisting eimeria tenella |
-
2006
- 2006-12-25 CN CNA2006101305430A patent/CN101209296A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552477A (en) * | 2010-12-09 | 2012-07-11 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition for treating chicken coccidiosis and preparation method thereof |
| CN102579697A (en) * | 2012-03-27 | 2012-07-18 | 贵州省畜牧兽医研究所 | Chinese herbal prescription for treating coccidiosis in chicken |
| CN102579697B (en) * | 2012-03-27 | 2013-07-03 | 贵州省畜牧兽医研究所 | Chinese herbal prescription for treating coccidiosis in chicken |
| CN103349718A (en) * | 2013-07-31 | 2013-10-16 | 华南农业大学 | Livestock and poultry cryptozoite infection prevention and treatment compound traditional Chinese medicine, preparation method and application thereof |
| CN103349718B (en) * | 2013-07-31 | 2015-02-25 | 华南农业大学 | Livestock and poultry cryptozoite infection prevention and treatment compound traditional Chinese medicine, preparation method and application thereof |
| CN103432441A (en) * | 2013-08-10 | 2013-12-11 | 安徽快康生物科技有限公司 | Traditional Chinese medicine composition for treating coccidiosis in chicken |
| CN103432441B (en) * | 2013-08-10 | 2016-03-02 | 安徽快康生物科技有限公司 | A kind of Chinese medicine composition for the treatment of Eimeria species |
| CN104491070A (en) * | 2014-12-10 | 2015-04-08 | 遵义师范学院 | Traditional Chinese medicinal extract compound used for preventing and treating chicken coccocidiosis and production method thereof |
| CN106344883A (en) * | 2016-11-16 | 2017-01-25 | 山东恩康药业有限公司 | Pure traditional Chinese medicine composition for resisting eimeria tenella |
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Open date: 20080702 |