CN101209297A - Compound Chinese medicinal granule for treating chicken coccidiosis - Google Patents
Compound Chinese medicinal granule for treating chicken coccidiosis Download PDFInfo
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- CN101209297A CN101209297A CNA200610130538XA CN200610130538A CN101209297A CN 101209297 A CN101209297 A CN 101209297A CN A200610130538X A CNA200610130538X A CN A200610130538XA CN 200610130538 A CN200610130538 A CN 200610130538A CN 101209297 A CN101209297 A CN 101209297A
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Abstract
The invention relates to a compound Chinese traditional medicine granule used for treating chicken coccidiosis, including four medicines of southernwood, dichroa febrifuga, Chinese bulbul and radix astragali. The invention is mainly used for treating various chicken coccidiosis diseases and also is used for treating the symptoms of bloody stool of sick chicken, emaciation, poor growth, and laying decline of adult chickens caused by chronic coccidial infection. The invention has the efficacies of clearing away heat and toxic material; considering the short avian genital tract and the special physiological structure of inability to digest lignocellulose, the medicine is prepared into soluble granules which can quickly be dissolved into drinking water which is absorbed by sick chickens so as to achieve the purpose of quick effect.
Description
Technical field
The invention belongs to the veterinary drug technical field, relate to a kind of herbal mixture granule that is used for the treatment of chicken coccidiosis.
Background technology
Coccidiosis is the very wide protozoacide of a kind of distribution.Very harmful to aviculture.This sick propagation is exceedingly fast, and during chicken house outburst coccidiosis, the chickling mortality rate can reach 80-100%.
Find that from Levine sulfa drugs is effective in cure to chicken coccidiosis, Grumbles at first with since the sulphaquinoxaline medicine prevention chicken coccidiosis, has developed more than 50 kind of anticoccidial chemical medicine.According to Bhoal, the year consumption of whole world anticoccidial drug is 3,300,000,000 dollars.China's number of raising chickens is 3,000,000,000～6,000,000,000 plumages, and on average consuming the anticoccidial expenses for medicine by every plumage broiler chicken is the 0.2-0.3 metaevaluation, and the anticoccidial drug expense that China is used for chicken every year reaches 600,000,000～1,800,000,000 yuans.Because the life-time service of anticoccidial chemical medicine, chicken coccidiosis produce drug resistance and have become unavoidable problem.As far back as 1945, the U.S. has just isolated from chicken house suspected that sulfa drugs is had drug-fast worm strain.In China, having isolated from the scene of raising chickens almost so far has the worm strain of resistance to all used anticoccidial chemical medicine, and shows cross-resistance to a certain degree.Be not resolved because of the development of coccidial vaccine and application remain at many critical problems, medical treatment is still the important means that tackles chicken coccidiosis in the recent period.
But Chinese herbal medicine has the little and worm of killing of toxic and side effects, strengthen characteristics, especially chicken coccidiosiss such as chicken body immunity function and growth promotion it is difficult for producing drug resistance, thereby vast potential for future development is arranged.
Shortcomings such as the Chinese medicine preparation that uses clinically mostly is powder at present, has administration inconvenience, and is short because of the digestive tract of chicken again, can not digest lignocellulose, and the drug absorption that causes is poor, and consumption is big.
Summary of the invention
Based on above-mentioned situation, the present invention aims to provide a kind of herbal mixture granule that is used for the treatment of chicken coccidiosis.
The object of the present invention is achieved like this: a kind of Chinese traditional compound medicine that is used for the treatment of chicken coccidiosis is characterized in that: Herba Artemisiae Annuae 3-5 part, Radix Dichroae 3-5 part, Radix Pulsatillae 2-3 part, Radix Astragali 2-3 part.
Be preferably: 3 parts of Herba Artemisiae Annuaes, 3 parts of Radix Dichroaes, 2 parts of the Radix Pulsatillaes, 2 parts of the Radixs Astragali.
A kind of Chinese traditional compound medicine that is used for the treatment of chicken coccidiosis is characterized in that: the dosage form of described Chinese traditional compound medicine is a granule.
Chinese veterinarian's theory thinks that coccidiosis is deficiency syndrome, and the rule of treatment is with anthelmintic hemostasis, strengthening vital QI to eliminate pathogenic factors.Main and auxiliary according to Chinese veterinarian, as to help, the make principles of formulating prescriptions, with Herba Artemisiae Annuae, Radix Dichroae parasite killing, analgesic is principal agent, is aided with Radix Pulsatillae heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery in the side; Assistant is with Radix Astragali strengthening vital QI to eliminate pathogenic factors, promoting pus discharge and tissue regeneration strengthening, diuretic detumescent.
The present invention adopts the industry method in common to make: with the four Chinese medicine material, decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.29-1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.
Below with concrete description of test effect of the present invention:
1 materials and methods
1.1 trial drug
Medicine of the present invention, main component are Herba Artemisiae Annuae, Radix Dichroae, the Radix Pulsatillae, the Radix Astragali, and recommended dose is 1.5g/1L, mix drink; Control drug is the ammonia third beautiful jade soluble powder (a hydrochloric Amprolium 10%), and amprolium hydrochloride is available from Sichuan company, lot number 010214.
1.2 experimental animal
350 AA broiler, available from the Nanjing Maigaoqiao company of raising chickens, be divided into seven groups at random, be respectively medicine high dose group of the present invention, dosage group in the medicine of the present invention, medicine low dose group of the present invention, medicine matched group (the ammonia third beautiful jade soluble powder group), negative control group (group is not treated in morbidity), positive controls (do not fall ill and do not treat group), safe matched group (according to 10 times of administration groups of recommended dose), 50 every group.Go out to be transported in this laboratory pouity dwelling place behind the shell and raise in cages, Routine Management is fed to complete feed to 21 age in days, is for experiment after excrement is examined the non-ball worm egg capsule.
1.3 artificial challenge
Except that positive controls and safe matched group, every plumage chicken gavages 100,000 spore Eimeria tenella egg capsules.
1.4 medication
It is soluble in water that every group of medicine pressed doses, allows chicken freely drink water.Administration when infecting, logotype 6 days.
1.5 drug effect criterion
1.5.1 survival rate (%): survival chicken number/beginning chicken number * 100.
1.5.2 the relative weight gain rate (%): medication group or infect the chicken average weight gain of not medication group/do not infect chicken average weight gain * 100 of not medication group, the relative weight gain rate that does not infect not medication group is 100%.
1.5.3 hemafecia is kept the score: with reference to morebouse and baron (1970) standard.
1.5.4 lesion score: press JohMon and Reid (1970) standard.
1.5.5 pathological changes value: average lesion score * 10 of every group of chicken.
1.5.6 egg capsule value: calculate by the clear method that provides in field, angle.
1.5.7 anticoccidial index (ACI): the method by Merck ﹠ Co., Inc. is calculated, i.e. ACI=(the relative weight gain rate+survival rate)-(pathological changes value+egg capsule value).
1.6 test grouping and processing: see Table 1:
Table 1 divides into groups and handles as shown in the table
2 results
Result of the test sees Table 2
Table 2 medicine of the present invention is to chicken coccidiosis result of the test table
Result by above test shows that the anticoccidial index of medicine various dose group of the present invention (basic, normal, high) is respectively 187.3,194.6 and 197.7, and middle and high dosage group belongs to the anticoccidial high efficiency levels, and low dose group also is in the effective range of anticoccidial; Medicine matched group anticoccidial index is 166.3, also belongs to the effect level of anticoccidial, with the anticoccidial index of low dose group of medicine of the present invention in the test in same scope.On rate of body weight gain, the middle and high dosage group of medicine of the present invention is the highest, and the comparative drug matched group can effectively improve chicken group's rate of body weight gain.In caecum lesion value and egg capsule value, medicine group of the present invention obviously contrasts the low of dosage group than medicine.Comprehensive every index can be found out middle and high dosage anticoccidial effect the best of medicine of the present invention, obviously is better than the anticoccidial effect of medicine contrast.
3 discuss
3.1 safety testing
50 chickens carry out safety experiment, and behind the medicine of the present invention of the safe dose of feeding (1.5g/L), feed intake, amount of drinking water all do not have significant change, and chicken group spirit is good, proves that medicine of the present invention is a safety to chicken.
Beneficial effect of the present invention: prescription of the present invention has the effect of heat-clearing and toxic substances removing, antagonism chicken coccidiosis has excellent curative, short in conjunction with the birds reproductive tract simultaneously, can not digest the special physiological structure of wood fibre, medicine is made soluble granule, after dissolving rapidly in feeding drinking-water, trouble chicken absorb by drinking-water, can reach the purpose of rapid onset.
The specific embodiment
Embodiment 1: 3 parts of Herba Artemisiae Annuaes, and 3 parts of Radix Dichroaes, 2 parts of the Radix Pulsatillaes, 2 parts of the Radixs Astragali decoct with water twice, and 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.Cure mainly the various coccidiosis of chicken.Also can be used for sick chicken drawstring bloody stool that chronic coccidium infection causes just, become thin, undergrowth, one-tenth chicken are laid eggs symptoms such as minimizing.Mix drink.Poultry: add this product 1.5 grams in per 1 premium on currency, a twice-daily is freely drunk, logotype 3-5 days; The serious symptom doubled amount is used.
Embodiment 2: 5 parts of Herba Artemisiae Annuaes, and 5 parts of Radix Dichroaes, 3 parts of the Radix Pulsatillaes, 3 parts of the Radixs Astragali decoct with water twice, and 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.Cure mainly the various coccidiosis of chicken.Also can be used for sick chicken drawstring bloody stool that chronic coccidium infection causes just, become thin, undergrowth, one-tenth chicken are laid eggs symptoms such as minimizing.Mix drink.Poultry: add this product 1.5 grams in per 1 premium on currency, a twice-daily is freely drunk, logotype 3-5 days; The serious symptom doubled amount is used.
Embodiment 3: 4 parts of Herba Artemisiae Annuaes, and 4 parts of Radix Dichroaes, 2 parts of the Radix Pulsatillaes, 2 parts of the Radixs Astragali decoct with water twice, and 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, being concentrated into relative density is the clear paste of 1.29～1.31 (65 ℃).Add right amount of auxiliary materials and granulate, the dry shaping of wet grain, packing, promptly.Cure mainly the various coccidiosis of chicken.Also can be used for sick chicken drawstring bloody stool that chronic coccidium infection causes just, become thin, undergrowth, one-tenth chicken are laid eggs symptoms such as minimizing.Mix drink.Poultry: add this product 1.5 grams in per 1 premium on currency, a twice-daily is freely drunk, logotype 3-5 days; The serious symptom doubled amount is used.
Claims (3)
1. a compound Chinese medicinal preparation that is used for the treatment of chicken coccidiosis is characterized in that: Radix Dichroae 3-5 part, Radix Pulsatillae 2-3 part, Radix Astragali 2-3 part.
2. a kind of compound Chinese medicinal preparation that is used for the treatment of avian colibacillosis according to claim 1 is characterized in that optimizing prescriptions of the present invention is: 3 parts of Herba Artemisiae Annuaes, 3 parts of Radix Dichroaes, 2 parts of the Radix Pulsatillaes, 2 parts of the Radixs Astragali.
3. a kind of compound Chinese medicinal preparation that is used for the treatment of chicken coccidiosis according to claim 1 is characterized in that: the dosage form of described Chinese traditional compound medicine is a granule.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA200610130538XA CN101209297A (en) | 2006-12-25 | 2006-12-25 | Compound Chinese medicinal granule for treating chicken coccidiosis |
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| CNA200610130538XA CN101209297A (en) | 2006-12-25 | 2006-12-25 | Compound Chinese medicinal granule for treating chicken coccidiosis |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101040924B (en) * | 2007-04-27 | 2010-11-03 | 天津生机集团有限公司 | Chinese traditional medicine for treating fowl coccidiosis and the preparing method thereof |
| CN102552477A (en) * | 2010-12-09 | 2012-07-11 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition for treating chicken coccidiosis and preparation method thereof |
| CN102716238A (en) * | 2012-06-21 | 2012-10-10 | 江西博大动物保健品有限公司 | Compound sweet wormwood health-care powder |
| CN102835594A (en) * | 2012-08-23 | 2012-12-26 | 青岛森源畜禽养殖有限公司 | Chinese medicinal epidemic prevention feed additive for chicken |
| CN103417654A (en) * | 2013-08-12 | 2013-12-04 | 河南惠通天下生物工程有限公司 | Traditional Chinese medicine composition for preventing and controlling poultry coccidiosis and preparation method of same |
| CN105663604A (en) * | 2014-11-19 | 2016-06-15 | 天津嘉瑞生物科技有限公司 | Traditional Chinese medicinal composition for treating chicken coccidiosis and preparation method of traditional Chinese medicinal composition |
| CN108066430A (en) * | 2018-01-11 | 2018-05-25 | 郑州福源动物药业有限公司 | A kind of sweet wormwood Changshan effervescence granular for animals and preparation method thereof |
| CN108096309A (en) * | 2017-06-30 | 2018-06-01 | 河南黑马动物药业有限公司 | A kind of formula for preventing chicken coccidiasis powder and preparation method thereof |
| CN108785399A (en) * | 2018-07-27 | 2018-11-13 | 洛阳瑞华动物保健品有限公司 | The Chinese and western medicinal composition and preparation method thereof that one breeder coccidiosis, hemostasis are enriched blood |
-
2006
- 2006-12-25 CN CNA200610130538XA patent/CN101209297A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101040924B (en) * | 2007-04-27 | 2010-11-03 | 天津生机集团有限公司 | Chinese traditional medicine for treating fowl coccidiosis and the preparing method thereof |
| CN102552477A (en) * | 2010-12-09 | 2012-07-11 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition for treating chicken coccidiosis and preparation method thereof |
| CN102716238A (en) * | 2012-06-21 | 2012-10-10 | 江西博大动物保健品有限公司 | Compound sweet wormwood health-care powder |
| CN102716238B (en) * | 2012-06-21 | 2014-06-18 | 江西博大动物保健品有限公司 | Compound sweet wormwood health-care powder |
| CN102835594A (en) * | 2012-08-23 | 2012-12-26 | 青岛森源畜禽养殖有限公司 | Chinese medicinal epidemic prevention feed additive for chicken |
| CN102835594B (en) * | 2012-08-23 | 2015-08-05 | 青岛森源畜禽养殖有限公司 | A kind of chick Chinese medicine bag for preventing infectious disease feed addictive |
| CN103417654A (en) * | 2013-08-12 | 2013-12-04 | 河南惠通天下生物工程有限公司 | Traditional Chinese medicine composition for preventing and controlling poultry coccidiosis and preparation method of same |
| CN103417654B (en) * | 2013-08-12 | 2016-02-10 | 河南惠通天下生物工程有限公司 | A kind ofly prevent and treat Chinese medicine composition of Avian Coccidia disease and preparation method thereof |
| CN105663604A (en) * | 2014-11-19 | 2016-06-15 | 天津嘉瑞生物科技有限公司 | Traditional Chinese medicinal composition for treating chicken coccidiosis and preparation method of traditional Chinese medicinal composition |
| CN108096309A (en) * | 2017-06-30 | 2018-06-01 | 河南黑马动物药业有限公司 | A kind of formula for preventing chicken coccidiasis powder and preparation method thereof |
| CN108066430A (en) * | 2018-01-11 | 2018-05-25 | 郑州福源动物药业有限公司 | A kind of sweet wormwood Changshan effervescence granular for animals and preparation method thereof |
| CN108785399A (en) * | 2018-07-27 | 2018-11-13 | 洛阳瑞华动物保健品有限公司 | The Chinese and western medicinal composition and preparation method thereof that one breeder coccidiosis, hemostasis are enriched blood |
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Open date: 20080702 |