CN108066430A - A kind of sweet wormwood Changshan effervescence granular for animals and preparation method thereof - Google Patents
A kind of sweet wormwood Changshan effervescence granular for animals and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
A kind of sweet wormwood Changshan effervescence granular for animals, belongs to field of traditional Chinese medicine pharmacy, which is prepared, raw material by the raw material and auxiliary material of following weight parts：Sweet wormwood 300, Changshan 300, the Chinese bulbul 200, Radix Astragali 200；Auxiliary material：Sodium acid carbonate 108 135, PEG6000 54 67.5, maleic acid 90 110, diluent 380 420.The present invention is alkali source with sodium acid carbonate, while it is wrapped up with PEG6000；It by the use of maleic acid as acid source, and adds auxiliary material and is prepared into sweet wormwood Changshan effervescence granular, preparation process is simple, easily molded, not easy to moisture absorption, and solution rate is fast, and effect is good, and melting is good, and dissolved liquid clarity is good, no breeze, foreign matter etc..Coccidiosis of livestock and poultry is treated, effect is good, and cure rate is high, does not recur.
Description
Technical field
The present invention relates to a kind of extracting methods of sweet wormwood Changshan, also relate to sweet wormwood Changshan effervescence granular for animals and its system
Preparation Method belongs to veterinary drug processing technique field.
Background technology
Medicinal extract is made by sweet wormwood, Changshan, the Chinese bulbul, astragalus extraction concentration in sweet wormwood Changshan particle, adds in auxiliary material, granulation and
Into.With the global-worm illness for through heat, cool blood, stop dysentery, treating chicken.It records and rises in veterinary drug national standard compilation-veterinary drug provincial standard
National standard（3rd）.According to sweet wormwood Changshan particle prepared by the method in quality standard, wherein sweet wormwood item discriminating is not met
Quality standard, and in Clinical practice, dissolving is slow, and palatability is poor.
Effervescence granular is to meet water with weak base using organic acid to generate carbon dioxide, and liquid is made to generate bubble and bubble is presented
A kind of granule of state is risen, compared with granule, without agitation during dissolving, can be made in a short time using cold water clear and bright
Liquid drug preparation, shorten dissolution time, easy to use, good absorbing, working, rapid, bioavilability is high and agreeable to the taste
Property is good.
Since the ratio shared by drug extract in Chinese medicine effervescence granular is great, in drug extract and pharmaceutic adjuvant species and ratio
Selection in terms of have difficulties, existing Chinese medicine effervescence granular mostly there are disintegration time is slow, stability is poor, palatability is poor etc. altogether
Sex chromosome mosaicism.Acid-base reaction of the effervescence granular during preservation because of disintegrant in itself simultaneously, in addition ambient water in storage process
The influence divided, easily generates gas, the product of preparation is made a problem that swollen bag, air-blowing occur.
The content of the invention
The purpose of the present invention is being to solve above-mentioned technical problem, a kind of inspection is provided and meets target level of product quality, is stablized
Property is good, disintegration time is rapid, clear sweet wormwood Changshan effervescence granular of solution and preparation method thereof.
The purpose of the present invention is be achieved through the following technical solutions：
The sweet wormwood Changshan effervescence granular of the present invention, it is prepared by the raw material and auxiliary material of following weight parts：
Raw material：Sweet wormwood 300, Changshan 300, the Chinese bulbul 200, Radix Astragali 200；
Auxiliary material：Sodium acid carbonate 108-135, PEG6000 54-67.5, maleic acid 90-110, diluent 380-420.
Organic solvent used includes：At least one of methanol, ethyl alcohol, ether, ethyl acetate are preferably ethyl alcohol.
The diluent is glucose, sucrose, lactose, soluble starch, microcrystalline cellulose, dextrin, mannitol, sorb
At least one of alcohol is preferably the mixture of mannitol and dextrin.
The preparation method of the sweet wormwood Changshan effervescence granular of the present invention carries out according to the following steps：
1st, sweet wormwood Changshan clear cream is extracted
(1) sweet wormwood for weighing recipe quantity is extracted with organic solvent, recycling design, and clear cream is for use；
(2) 10 times of water is added to impregnate Artemisia annua after extraction and Changshan, the Chinese bulbul, Radix Astragali, when decoction 1.5 is small for the first time, second
It is secondary add in 8 times of water decoct 1 it is small when, merge decoction liquor, filtration, filtrate decompression is concentrated into relative density as 1.22~1.25
（80℃）；
(3) will（1）（2）Clear cream use after mixing.
2nd, the preparation of effervescence granular：
After PEG6000 heating meltings, sodium acid carbonate is added in, stirs evenly, after cooling, is ground into fine powder（Cross 80 mesh sieves）
（The ratio of PEG6000 and sodium acid carbonate is 0.5:1）, medicinal extract and diluent, maleic acid, sodium acid carbonate polymer are taken, is stirred, system
Into homogeneous softwood, No. 1 sieve whole grain, 60 DEG C of oven dryings, No. 1 sieve whole grain of dry particl.The effervesce that above-mentioned steps are obtained
Grain, packing.
In order to which inspection result is made to meet quality standard, applicant carries out sweet wormwood decoction liquor and sweet wormwood organic solvent extracting solution
Extraction solvent is screened in comparison, optimizes solvent dosage.
In order to increase the stability of effervescence granular, applicant strictly screens disintegrant in prescription, particularly to acid
Source is screened, while is wrapped up using alkali source with PEG.Optimize the dosage of the two, reduce the possibility that disintegrant contacts with each other
Property；And its stability is investigated, it is ensured that product has good effervesce effect and dissolve effect during storage and use
Fruit, a problem that swollen bag, air-blowing will not be generated.
The present invention, as alkali source, is wrapped up with PEG6000 using sodium acid carbonate, using maleic acid as acid source, and added
Add sweet wormwood Changshan effervescence granular prepared by other auxiliary materials that can reduce supplementary product consumption, preparation process is simple, easily molded, not easy to moisture absorption,
Solution rate is fast, and solute effect is good, and melting is good, after dissolving liquid clarity it is good, without breeze foreign matter etc..
Specific embodiment
First, the research of sweet wormwood Changshan clear cream extraction process：
Veterinary drug national standard compilation-veterinary drug provincial standard rises national standard（3rd）Prescription and preparation method in specify it is each
The amount of taste medicinal material, the number of extracting in water and amount obtained.Former technique is：Sweet wormwood 300g, Changshan 300g, Chinese bulbul 200g,
Radix Astragali 200g, more than 4 tastes, add water to cook twice, collecting decoction, filter, concentration is examined to be made medicinal extract, add in auxiliary material, pelletize, do
It is dry, be made 500g to get.
On the basis of original prescription and former technique, the particle sweet wormwood item discriminating of the medicinal extract preparation extracted is unqualified.Together
When there is no the water for impregnating medicinal material and extraction time, in order to ensure the stability and controllability of the granulation of sweet wormwood Changshan particle, and make
The medicament contg of sweet wormwood Changshan effervescence granular can be consistent with the content of sweet wormwood Changshan granule medicament, even above sweet wormwood Changshan
Grain, applicant are screened and are optimized to the Extraction solvent of sweet wormwood and the dosage of solvent.And the extraction process of sweet wormwood Changshan clear cream
It is studied, mainly starts in terms of amount of water and decocting time two, examined using yield of extract as leading indicator using single factor test
The method of examining is investigated.Sweet wormwood Changshan effervescence granular screens alkali source and acid source.
2nd, sweet wormwood Extraction solvent
Tap water is selected to extract 2 times, adds 8 times of water every time, when decoction 1 is small.2 times are extracted with 70% ethyl alcohol, and 8 times of 70% ethyl alcohol returns every time
Flow 30 it is small when, using thin layer collection of illustrative plates as foundation.
The result shows that the active ingredient in Artemisia annua can be extracted very well with 70% ethyl alcohol, with main component in control medicinal material more
Unanimously.
3rd, the screening of sweet wormwood Changshan effervescence granular formulation and technology
1st, the screening of acid source and alkali source
In the selection of effervescent agent, sodium acid carbonate is as alkali source, and dosage is few, and gas production is big, and the present invention uses sodium acid carbonate conduct
Alkali source.Due to the easy moisture absorption of Chinese medical concrete, viscosity is big, so the selection of acid source is critically important.Weigh a certain amount of medicinal extract respectively with acid
Source and alkali source are uniformly mixed, and are pelletized respectively with ethyl alcohol, carry out recipe determination.It the results are shown in Table.
The selection result of acid source and alkali source
When tartaric acid is as acid source, since calcium and magnesium ion present in tartaric acid and ordinary water combines, white flock precipitate is generated,
Clarity is bad after dissolving, influences sense organ, has been confirmed in prescription 4, therefore selects prescription 1, using maleic acid as effervesce
The acid source of agent.
2nd, the selection of auxiliary material
Since the medicinal material dosage of this preparation is that 1g particles are equivalent to 2g medicinal materials, the medicinal extract amount for decocting out is quite big, with anhydrous Portugal
The addition result that grape sugar and mannitol, sucrose, lactose do medicinal extract when auxiliary material prepares particle is as follows：
Show according to result of the test：The mannitol that should select that full dose medicinal extract can be added is as auxiliary material.
3rd, prescription screening experimental design
Due to containing traditional Chinese medicine extraction medicinal extract in this preparation, viscosity is big, therefore the ratio of soda acid is selected to have to moderate, can be only achieved bubble
The requirement of disintegration is risen, general acid/base ratio is 0.8: 1, but also it has been reported that the dosage of acid is more than theoretical amount, bubble obtained
Rise particle could stablize with it is agreeable to the taste.Therefore, according to the characteristics of various auxiliary materials and performance, with the disintegration time of effervescence granular, granulation
Difficulty, appearance, melting etc. as inspection target, the acid/base ratio in prescription and the dosage of other auxiliary materials are sieved
Choosing.
Prescription screening experimental design and result
As can be seen from the test results, the disintegration time of prescription 6 is minimum, and appearance, palatability and melting are good, therefore determines
Prescription 5 is technical scheme.
4th, granulating process determines
This preparation prepares effervescence granular using medicinal extract, contains in medicinal extract compared with juicy, to avoid acid-base reaction in pelletization, therefore
Alkali source using PEG6000 is wrapped up, is then pelletized again with other compositions.
After the PEG6000 heating meltings of recipe quantity, sodium acid carbonate is added in, stirs evenly, after cooling, is ground into fine powder
（Cross 80 mesh sieves）（The ratio of PEG6000 and sodium acid carbonate is 0.5:1）；Take medicinal extract and diluent, maleic acid, sodium acid carbonate polymerization
Homogeneous softwood, No. 1 sieve whole grain, 60 DEG C of oven dryings, No. 1 sieve whole grain of dry particl is made in object, stirring.Above-mentioned steps are obtained
The effervescence granular arrived, dispense to get.
Embodiment 1
1st, sweet wormwood Changshan effervescence granular is prepared by the raw material and auxiliary material of following weight proportions：
Raw material is：Sweet wormwood 300g, Chinese bulbul 300g, Radix Astragali 200g, Changshan 200g；
Auxiliary material is：Sodium acid carbonate 105g, PEG6000 52.5g, maleic acid 90g；Diluent：Mannitol 402.5g.
2nd, the preparation method of sweet wormwood Changshan effervescence granular, carries out according to the following steps：
（1）The sweet wormwood for weighing recipe quantity adds 60% ethyl alcohol, 8 times of heating and refluxing extractions twice, every time 1 it is small when, recycling dissolving, concentrate
For use；
（2）Sweet wormwood（Extraction）, the Chinese bulbul, Radix Astragali, Changshan, by 10 times of water, decoct 1.5 it is small when, it is small to decoct 1 for second plus 8 times of water
When, concentration is for use；
（3）It will（1）（2）Concentrate it is for use after mixing；
（4）The preparation of PEG polymer after PEG6000 heating meltings, adds sodium acid carbonate, stirs evenly, after cooling, after crushing
Cross 80 mesh screens（The ratio of PEG6000 and sodium acid carbonate is 0.5:1）；
（5）Take medicinal extract（3）With diluent, maleic acid, sodium acid carbonate polymer, homogeneous softwood is made in stirring, and No. 1 is sieved whole grain,
60 DEG C of oven dryings, No. 1 sieve whole grain of dry particl.The effervescence granular that above-mentioned steps are obtained, dispense to get.
Embodiment 2
1st, sweet wormwood Changshan effervescence granular is prepared by the raw material and auxiliary material of following weight proportions：
Raw material is：Sweet wormwood 300g, Chinese bulbul 300g, Radix Astragali 200g, Changshan 200g；
Auxiliary material is：Sodium acid carbonate 110g, PEG6000 65g, diluent：Mannitol 475g；
2nd, the preparation method of sweet wormwood Changshan effervescence granular, carries out according to the following steps：
（1）The sweet wormwood for weighing recipe quantity adds 70% ethyl alcohol, 8 times of heating and refluxing extractions twice, every time 1 it is small when, recycling dissolving, concentrate
For use；
（2）Sweet wormwood（Extraction）, the Chinese bulbul, Radix Astragali, Changshan, by 10 times of water, decoct 1.5 it is small when, it is small to decoct 1 for second plus 8 times of water
When, concentration is for use；
（3）It will（1）（2）Concentrate it is for use after mixing；
（4）The preparation of PEG polymer after PEG6000 heating meltings, adds sodium acid carbonate, stirs evenly, after cooling, after crushing
Cross 80 mesh screens（The ratio of PEG6000 and sodium acid carbonate is 0.5:1）；
（5）Take medicinal extract（3）With diluent, maleic acid, sodium acid carbonate polymer, homogeneous softwood is made in stirring, and No. 1 is sieved whole grain,
60 DEG C of oven dryings, No. 1 sieve whole grain of dry particl.The effervescence granular that above-mentioned steps are obtained, dispense to get.
Embodiment 3
1st, sweet wormwood Changshan effervescence granular is prepared by the raw material and auxiliary material of following weight proportions：
Raw material is：Sweet wormwood 300g, Chinese bulbul 300g, Radix Astragali 200g, Changshan 200g；
Auxiliary material is：Sodium acid carbonate 132g, PEG6000 66g, diluent：Mannitol 452g；
2nd, the preparation method of sweet wormwood Changshan effervescence granular, carries out according to the following steps：
（1）The sweet wormwood for weighing recipe quantity adds 80% ethyl alcohol, 8 times of heating and refluxing extractions twice, every time 1 it is small when, recycling dissolving, concentrate
For use；
（2）Sweet wormwood（Extraction）, the Chinese bulbul, Radix Astragali, Changshan, by 10 times of water, decoct 1.5 it is small when, it is small to decoct 1 for second plus 8 times of water
When, concentrate is for use；
（3）It will（1）（2）Concentrate it is for use after mixing；
（4）The preparation of PEG polymer after PEG6000 heating meltings, adds sodium acid carbonate, stirs evenly, after cooling, after crushing
Cross 80 mesh screens（The ratio of PEG6000 and sodium acid carbonate is 0.5:1）；
（5）Take medicinal extract（3）With diluent, maleic acid, sodium acid carbonate polymer, homogeneous softwood is made in stirring, and No. 1 is sieved whole grain,
60 DEG C of oven dryings, No. 1 sieve whole grain of dry particl.The effervescence granular that above-mentioned steps are obtained, dispense to get.
4th, sweet wormwood Changshan granule stability is tested
The effervescence granular of the present invention is taken, commercially available back is simulated, is placed under the conditions of 25 ± 2 DEG C of temperature, relative humidity 65% ± 10%,
It samples and is investigated respectively at 0,3,6,9,12 ... the months, investigate result and see the table below
1. moisture：According to《Chinese veterinary pharmacopoeia》2015 editions 1 aquametries (annex 0832).
2. melting：Taking 3 crowdes of each 10g of effervescence granular respectively, heating water 200ml generates rapidly gas and in effervesce shape,
5min endoparticles are completely dispersed and are dissolved in water, and solution clarifies bright, the foreign matters such as no breeze.
3. disintegration time limited：Effervescence granular is checking in the time limit that all disintegrations leach or into particle and the institute that is dissolved in water
The time needed.
Sweet wormwood Changshan effervescence granular stability test
Through being examined to character, moisture, discriminating item etc. are many-sided, in probation, the effervescence granular prepared using the present invention is met
《Chinese veterinary pharmacopoeia》It is required that：By stability test in 12 months, product characteristics were without significant change, moisture ＜ 5%, melting
Preferably, and the effervescence granular effervesce of preparation is rapid, solution clarification, no precipitation, and the foreign matters such as no breeze, appearance is good, so as to illustrate this
Effervescence granular property prepared by invention is stablized, quality controllable.
Clinical test one
28 aa broiler chicken natural infection global-worm illness of Shandong farm, down in spirits close blurred vision and sleep, loss of appetite or useless
Absolutely, the clinical symptoms of the typical global-worm illness such as blood sample excrement are arranged；Pathology dissect has typical intestinal bleeding lesion;It can be from intestinal contents
With a large amount of coccidian oocysts are found in excrement.After sweet wormwood Changshan effervescence granular, the survival rate of diseased chicken is 94%, body weight increase rate
For 127.9%, anticoccidial index 183.Feed intake increases, and returns to normal after a week.
Clinical test two
Baoding livestock-raising field, 2000 plumage of coccidia diseased chicken of natural occurrence, after product 3d, diseased chicken is in high spirits
Turning, appetite excrement recovers normal, cure rate is up to 98.5%, and no relapse.
Claims (5)
1. a kind of sweet wormwood Changshan effervescence granular for animals, which is characterized in that it is prepared by the supplementary material of following parts by weight：
Raw material：Sweet wormwood 300, Changshan 300, the Chinese bulbul 200, Radix Astragali 200；Auxiliary material：Sodium acid carbonate 108-135, PEG6000 54-
67.5, maleic acid 90-110, diluent 380-420.
2. sweet wormwood Changshan effervescence granular according to claim 1, it is characterised in that organic solvent used includes：Methanol,
At least one of ethyl alcohol, ether, ethyl acetate are preferably ethyl alcohol.
3. sweet wormwood Changshan effervescence granular according to claim 1, it is characterised in that diluent used is glucose, sugarcane
At least one of sugar, lactose, soluble starch, microcrystalline cellulose, dextrin, mannitol, sorbierite are preferably mannitol.
4. sweet wormwood Changshan effervescence granular according to claim 1, it is characterised in that its medicinal material extract method is by following step
Suddenly carry out：
1. the sweet wormwood for weighing recipe quantity is extracted with organic solvent, recycling design, clear cream is for use；
2. Artemisia annua after extraction is impregnated again with Changshan, the Chinese bulbul, Radix Astragali by 10 times of water, when decoction 1.5 is small for the first time, the
It is secondary add in 8 times of water decoct 1 it is small when, merge decoction liquor, filtration, filtrate decompression is concentrated into relative density as 1.22~1.25
（80℃）；
3. two kinds of medicinal extract are used after mixing.
5. sweet wormwood Changshan effervescence granular according to claim 1, it is characterised in that the method for granulating of effervescence granular be by with
What lower step carried out：After PEG6000 heating meltings, sodium acid carbonate is added in, stirs evenly, after cooling, is ground into fine powder（Cross 80
Mesh sieve）（The ratio of PEG6000 and sodium acid carbonate is 0.5:1）, medicinal extract and diluent, maleic acid, sodium acid carbonate polymer are taken, is stirred
It mixes, softwood, No. 1 sieve whole grain, 60 DEG C of oven dryings, dry particl No. 1 sieve whole grain, packing is made.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108785399A (en) * | 2018-07-27 | 2018-11-13 | 洛阳瑞华动物保健品有限公司 | The Chinese and western medicinal composition and preparation method thereof that one breeder coccidiosis, hemostasis are enriched blood |
| CN110731943A (en) * | 2019-10-15 | 2020-01-31 | 河南牧翔动物药业有限公司 | halofuginone hydrobromide soluble powder and its preparation method |
| CN114848698A (en) * | 2022-06-10 | 2022-08-05 | 保定冀中药业有限公司 | Artemisia apiacea and dichroa febrifuga effervescent granules for treating bacterial gill-rot disease and preparation method thereof |
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| CN108785399A (en) * | 2018-07-27 | 2018-11-13 | 洛阳瑞华动物保健品有限公司 | The Chinese and western medicinal composition and preparation method thereof that one breeder coccidiosis, hemostasis are enriched blood |
| CN110731943A (en) * | 2019-10-15 | 2020-01-31 | 河南牧翔动物药业有限公司 | halofuginone hydrobromide soluble powder and its preparation method |
| CN114848698A (en) * | 2022-06-10 | 2022-08-05 | 保定冀中药业有限公司 | Artemisia apiacea and dichroa febrifuga effervescent granules for treating bacterial gill-rot disease and preparation method thereof |
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