CN102961418B - Compound Hippophae rhamnoides dipyridamole tablet and preparation method thereof - Google Patents
Compound Hippophae rhamnoides dipyridamole tablet and preparation method thereof Download PDFInfo
- Publication number
- CN102961418B CN102961418B CN201210430554.6A CN201210430554A CN102961418B CN 102961418 B CN102961418 B CN 102961418B CN 201210430554 A CN201210430554 A CN 201210430554A CN 102961418 B CN102961418 B CN 102961418B
- Authority
- CN
- China
- Prior art keywords
- extract
- dipyridamole
- fructus hippophae
- hippophae
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a compound Hippophae rhamnoides dipyridamole tablet and a preparation method thereof. The compound is prepared from a Hippophae rhamnoides extract, dipyridamole, a diluent, a lubricant and an adhesive. The preparation method comprises the steps of: extracting a Hippophae rhamnoides crude extract from Hippophae rhamnoides fruits; refining the crude extract with ethanol with volume percentage concentration higher than 95%; crushing and sieving the refined extract, dipyridamole and the diluent; adding the adhesive into the treated raw materials and auxiliary materials, and uniformly mixing the materials in a mixer granulator to form a soft material; sending the soft material into a multifunctional granulator for granulation; drying the wet particles evenly into a boiling dryer; adding the lubricant in the dried particles, mixing the mixture well in a mixing machine; and conducting tabletting, coating and packaging to obtain a finished product. The invention utilizes efficacies of flavonoids bioactive substances, such as dilating coronary artery and lowering cholesterol, and effects of dipyridamole, such as resisting thrombosis and dilating vessel, and combines traditional Chinese medicine and Western medicine; and the tablet has advantages of convenient clinical usage, stable quality, low dosage and more effective effects.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, particularly relate to two phonetic of a kind of compound hippophae rhamnoides and preparation method thereof.
Background technology
Fructus Hippophae (
hippophae rhamnoides Linn.) be Elaeangnaceae Hippophae, be a kind of fallen leaves property shrub or arbor, the geographical distribution of Fructus Hippophae is very wide, across Eurasian two Temperate Region in Chinas, continent, is divided into six kinds and 12 subspecies.China is hippophae plant areal area area maximum, the country of most species.There are at present 19 province and municipalities such as Shanxi, Shaanxi, the Inner Mongol, Hebei, Gansu, Ningxia, Liaoning, Qinghai, Sichuan, Yunnan, Guizhou, Xinjiang, Tibet to have distribution.
Fructus Hippophae is a kind of medicinal and edible plant that contains various bioactivators.China has long Fructus Hippophae medicinal history, is the country the earliest of the medical record of Fructus Hippophae in the world, and the Chinese Tibetan medicine in ancient times and Mongolian medicine have classified Fructus Hippophae as important medicinal plants, for cough-relieving, relieving asthma, blood circulation promoting and blood stasis dispelling etc.Tibetan medicine's monumental work Four-Volume Medical Code in eightth century of Christian era has done detailed record to the drug effect of Fructus Hippophae, and Christian era, the classic " Jingzhubencao " of Tibetanmedicine in 1840 was also recorded the medicine effect of Fructus Hippophae with a large amount of lengths.In modern age, the Tibetan, the compatriot of Meng ethnic group that are located in an outlying district still treat various commonly encountered diseases with Fructus Hippophae.Within 1977, ministry of Health of China is formally listed Fructus Hippophae in " Chinese Pharmacopoeia " first.Afterwards, to combine announcement Fructus Hippophae be medicinal and edible plant for country medicine office and Ministry of Public Health.
Chemical composition analysis to plant Fructus Hippophae shows: in Fructus Hippophae, contain various bioactivators, be rich in multivitamin, carotene, each seed amino acid, unsaturated fatty acid and flavone compound, phospholipids compounds.7 kinds of Flavonoid substances such as isorhamnetin wherein and glucoside thereof, Quercetin, nimbecetin, the usefulness that has cough-relieving, relievings asthma and eliminate the phlegm, expand coronary vasodilator, reduce cholesterol, is usually used in treating ischemic heart desease, and treatment angina pectoris effective percentage is reached to 94%.
Dipyridamole anticoagulant, has the effect of antithrombotic formation and blood vessel dilating, and high concentration (50ug/ml) can suppress platelet and discharge.Mechanism of action may be: (1) suppress platelet picked-up adenosine, and adenosine is a kind of platelet response inhibitor; (2) suppress phosphodiesterase, cyclic adenosine monophosphate (cAMP) in platelet is increased; (3) suppress thromboxane element A2(TXA2) form, TXA2 is the powerful agonist of biologically active pdgf; (4) strengthen endogenous PGI2.
At present, taking Fructus Hippophae as raw material, research and development are prepared into multiple Chinese patent medicine preparation or health product, as hippophae rhamnoides patch, sea-buckthorn particle use clinically in a large number as OTC (over-the-counter).Owing to being subject to the restriction of traditional handicraft, existing pharmaceutical preparation can not meet clinical and needs market far away.The present invention is intended to research and utilization flavonoid bioactive substance has expansion coronary vasodilator, the efficiency and function that reduces cholesterol and dipyridamole to have the effect of anti-thrombosis function and blood vessel dilating, Chinese medicine and western medicine combination, provides two phonetic of a kind of compound hippophae rhamnoides that can be used for reducing blood pressure, reduces Blood Cholesterol and prevention of arterial gruel type.
Summary of the invention
The invention provides two phonetic of a kind of compound hippophae rhamnoides and preparation method thereof, the two phonetic Chinese medicine and western medicine combinations of its compound hippophae rhamnoides, can be used for reducing blood pressure, reduce Blood Cholesterol and prevention of arterial gruel type, clinical application convenience, steady quality and dose are little, act on more effective.
The invention provides two phonetic of a kind of compound hippophae rhamnoides, it is made up of Fructus Hippophae extract, dipyridamole and diluent, lubricant, binding agent, and wherein Fructus Hippophae extract, dipyridamole and diluent are 10-50:1-5:2.5-5 by weight proportional quantity; Described diluent is the ratio combination with 1:1 of any one or sugarcane sugar and starch in sucrose, starch; Lubricant is magnesium stearate; Binding agent is 75% ethanol.
The preparation method that the invention provides two phonetic of above-mentioned compound hippophae rhamnoides, comprises the steps:
(1) from Fructus Hippophae, extract Fructus Hippophae crude extract;
(2) by concentration expressed in percentage by volume, more than 95% ethanol extracts Fructus Hippophae crude extract again, thereby obtains Fructus Hippophae extract;
(3) Fructus Hippophae extract, dipyridamole and the diluent of proportional quantity are pulverized and sieved processing;
(4) supplementary material after treatment adds binding agent and in mixer-granulator, stirs and make soft material;
(5) getting above-mentioned soft material sends in Multifunction granulating machine and granulates;
(6) evenly to send into ebullated dryer dry for the wet grain of gained, makes dry granule water content reach prescribed limit;
(7) granule being dried adds lubricant to mix in mixer;
(8) tabletting: select punch die specification, first-class punch die, regulates loading, regulates pressure, and the sheet weight, hardness, disintegration, outward appearance etc. of tabletting are conformed to quality requirements;
(9) coating: plain sheet → sealing coat → sub-coat → sugarcoating layer → color clothing layer → polishing;
(10) packaging.
Wherein step (2) is preferably used 95% ethanol again Fructus Hippophae extract to be extracted; The mixing that the preferred diluent of step (3) is sucrose, starch is used; The preferred binding agent of step (4) is 75% ethanol; The preferred lubricant of step (7) is magnesium stearate.
Because Fructus Hippophae extract is a kind of plant amedica, its composition is comparatively complicated, in order to extract better its effective ingredient, reduce various impurity, improve medicine effectiveness, reduce security risk, through many experiments, research is found: in the time preparing Fructus Hippophae extract, more than 95% ethanol of use carries out essence to Fructus Hippophae extract to be carried, and can effectively remove the lactone, the tannin etc. that in extract, are slightly soluble in water, thereby increases the quality stability of pharmaceutical preparation.In addition, Fructus Hippophae extract is combined with dipyridamole Chinese medicine and western medicine and is made combination drug and can make drug effect larger, and diluent sugarcane sugar and starch mixes and uses the medicine of preparation better than any the medicine result of extraction prepared in independent use sucrose or starch.Comprehensively show said preparation compound hippophae rhamnoides two phonetic can make some Long-term taking medicine, the patient's dosage such as difficulty, advanced age of taking medicine reduces, and onset is rapid, clinical application is convenient, quality safety, effectively, stable.
The invention has the advantages that:
(1) Fructus Hippophae extract is carried out to essence and carry, effectively remove the lactone, the tannin etc. that are slightly soluble in water, increase the quality stability of pharmaceutical preparation;
(2) prescription science, advanced technology, safe and effective;
(3) Chinese medicine and western medicine combination, curative effect guarantee, medication dose is little;
(4) be applicable to promoting on a large scale clinically.
Detailed description of the invention
Further illustrate the present invention by following specific embodiment, but be not used for limiting the scope of the invention.
embodiment 1
(1) extract Fructus Hippophae crude extract: get fresh Fructus Hippophae, squeeze extracting juice after choosing clean foreign material, filter fruit juice, filtrate is for subsequent use.Marc adds appropriate 70% alcohol reflux 2 times, and each 2 hours, extracting solution merged with filtrate after reclaiming ethanol, and the filtrate after merging is concentrated into 1/4 of original volume; Concentrated solution is left standstill, cross leaching supernatant, filtrate is through D101 macroporous resin adsorption, ethanol elution, eluent is concentrated into without alcohol taste, then add the purified water of 1.5 times of Fructus Hippophae weight, stir cooling rear leaving standstill, filter, filtrate concentrates receives cream, vacuum drying to water content is 6%(weight) below, pulverize, make Fructus Hippophae crude extract;
(2) extract Fructus Hippophae extract: the ethanol that adds the concentration expressed in percentage by volume 95% of 5 times of weight in Fructus Hippophae crude extract, be stirred to dissolving, after centrifugalize, be concentrated into without alcohol taste, then add the purified water of 8 times of concentrated rear medicine liquid volumes, stir cooling rear leaving standstill, get supernatant, the concentrated cream of receiving after centrifugalize, vacuum drying to water content in 5%(weight) below, pulverize.
(3) the two phonetic preparations of compound hippophae rhamnoides:
(I) prescription composition (1000 tablet recipe amount)
Fructus Hippophae extract: 400g
Dipyridamole: 25g
Starch: 50g
Sucrose: 50g
Magnesium stearate: 5g
Binding agent: 75% appropriate amount of ethanol
(II) preparation process:
(a) Fructus Hippophae extract of proportional quantity, dipyridamole and diluent are pulverized to the processing of sieving;
(b) supplementary material after treatment is put in mixer-granulator and is stirred, and adds binding agent continuation stirring and makes soft material;
(c) soft material is sent in Multifunction granulating machine and is granulated;
(d) will wet grain evenly send into ebullated dryer inner drying, make dry granule water content reach prescribed limit;
(e) granule of granulate being crossed is placed in mixer, adds lubricant to make it mix homogeneously;
(f) tabletting: select punch die specification, first-class punch die, regulates loading, regulates pressure, and the sheet weight, hardness, disintegration, outward appearance etc. of tabletting are conformed to quality requirements;
(g) coating: plain sheet → sealing coat → sub-coat → sugarcoating layer → color clothing layer → polishing;
(i) packaging.
embodiment 2
(1) extract Fructus Hippophae crude extract: identical with embodiment 1;
(2) extract Fructus Hippophae extract: the ethanol that adds the concentration expressed in percentage by volume 95% of 8 times of weight in Fructus Hippophae extract, be stirred to dissolving, after centrifugalize, be concentrated into without alcohol taste, then add the purified water of 8 times of concentrated rear medicine liquid volumes, stir cooling rear leaving standstill, get supernatant, the concentrated cream of receiving after centrifugalize, vacuum drying to water content in 5%(weight) below, pulverize.
(3) the two phonetic preparations of compound hippophae rhamnoides:
(I) prescription composition (1000 tablet recipe amount)
Fructus Hippophae extract: 400g
Dipyridamole: 25g
Starch: 50g
Sucrose: 50g
Magnesium stearate: 5g
Binding agent: 75% appropriate amount of ethanol
(II) preparation process: identical with embodiment 1.
embodiment 3
(1) extract Fructus Hippophae crude extract: identical with embodiment 1;
(2) extract Fructus Hippophae extract: the dehydrated alcohol that adds 5 times of weight in Fructus Hippophae extract, be stirred to dissolving, after centrifugalize, be concentrated into without alcohol taste, then add the purified water of 8 times of concentrated rear medicine liquid volumes, stir cooling rear leaving standstill, get supernatant, the concentrated cream of receiving after centrifugalize, vacuum drying to water content in 5%(weight) below, pulverize.
(3) the two phonetic preparations of compound hippophae rhamnoides:
(I) prescription composition (1000 tablet recipe amount)
Fructus Hippophae extract: 400g
Dipyridamole: 25g
Starch: 50g
Sucrose: 50g
Magnesium stearate: 5g
Binding agent: 75% appropriate amount of ethanol
(II) preparation process: identical with embodiment 1.
embodiment 4
(1) extract Fructus Hippophae crude extract: identical with embodiment 1;
(2) extract Fructus Hippophae extract: identical with embodiment 1;
(3) the two phonetic preparations of compound hippophae rhamnoides:
(I) prescription composition (1000 tablet recipe amount)
Fructus Hippophae extract: 400g
Dipyridamole: 25g
Starch: 100g
Magnesium stearate: 5g
Binding agent: 75% appropriate amount of ethanol
(II) preparation process: identical with embodiment 1.
embodiment 5
(1) extract Fructus Hippophae crude extract: identical with embodiment 1;
(2) extract Fructus Hippophae extract: identical with embodiment 1;
(3) the two phonetic preparations of compound hippophae rhamnoides:
(I) prescription composition (1000 tablet recipe amount)
Fructus Hippophae extract: 400g
Dipyridamole: 25g
Sucrose: 100g
Magnesium stearate: 5g
Binding agent: 75% appropriate amount of ethanol
(II) preparation process: identical with embodiment 1.
comparative example:
(1) extract Fructus Hippophae crude extract: identical with embodiment 1;
(2) the two phonetic preparations of compound hippophae rhamnoides: the Fructus Hippophae extract that step (1) is made is without refining two phonetic of the compound hippophae rhamnoides of directly preparing.Preparation process is identical with embodiment 1.
experimental example 1:
The sample that the sample that embodiment 1-5 is made and comparative example make compares test at character, content, related substance, dissolution according to the method for 2010 editions regulations of Chinese Pharmacopoeia simultaneously, the results are shown in Table 1.
Table 1: the sample survey result that embodiment 1-5 and comparative example make
Can be found out by upper table result, sample related substance prepared by the Fructus Hippophae extract after refining is starkly lower than sample prepared by unpurified Fructus Hippophae extract, and in the time preparing medicine, when any when adding separately sugarcane sugar and starch of the sample while simultaneously adding sugarcane sugar and starch, the result of extraction of sample is good.
experimental example 2
Two phonetic of compound hippophae rhamnoides that embodiment 1 is obtained is put in calorstat and is placed 10 days under 60 DEG C of conditions, respectively at 5 days, 10 days pick test, the results are shown in Table 2.
Table 2 high temperature experimental result
Can be found out by the above results: sample is placed 10 days under 60 DEG C of conditions, institute's investigation project is without significant change.
experimental example 3
The two phonetic lighting box (4500LX) that are placed in daylight lamp of compound hippophae rhamnoides that embodiment 1 is prepared are placed 10 days, respectively at 5 days, 10 days pick test, the results are shown in Table 3.
Table 3 illumination experiment result
Can be found out by the above results: sample is placed 10 days under illumination condition, institute's investigation project is without significant change.
experimental example 4
Two phonetic of compound hippophae rhamnoides that embodiment 1 is prepared is placed in KNO is housed
3the exsiccator of saturated solution is placed 10 days, respectively at 5 days, 10 days pick test, the results are shown in Table 4.
Table 4 high humidity experimental result
Can be found out by the above results: sample is placed 10 days under super-humid conditions, institute's investigation project is without significant change.
The preparation of tablet of the present invention:
embodiment 6
(1) extract Fructus Hippophae crude extract: identical with embodiment 1;
(2) extract Fructus Hippophae extract: identical with embodiment 1;
(3) the two phonetic preparations of compound hippophae rhamnoides:
(I) prescription composition (1000 tablet recipe amount)
Fructus Hippophae extract: 300g
Dipyridamole: 20g
Starch 50g
Sucrose: 50g
Magnesium stearate: 5g
Binding agent: 75% appropriate amount of ethanol
(II) preparation process: identical with embodiment 1.
embodiment 7
(1) extract Fructus Hippophae crude extract: identical with embodiment 1;
(2) extract Fructus Hippophae extract: identical with embodiment 1;
(3) the two phonetic preparations of compound hippophae rhamnoides:
(I) prescription composition (1000 tablet recipe amount)
Fructus Hippophae extract: 500g
Dipyridamole: 20g
Starch 50g
Sucrose: 50g
Magnesium stearate: 5g
Binding agent: 75% appropriate amount of ethanol
(II) preparation process: identical with embodiment 1.
embodiment 8
(1) extract Fructus Hippophae crude extract: identical with embodiment 1;
(2) extract Fructus Hippophae extract: identical with embodiment 1;
(3) the two phonetic preparations of compound hippophae rhamnoides:
(I) prescription composition (1000 tablet recipe amount)
Fructus Hippophae extract: 300g
Dipyridamole: 30g
Starch 50g
Sucrose: 50g
Magnesium stearate: 5g
Binding agent: 75% appropriate amount of ethanol
(II) preparation process: identical with embodiment 1.
embodiment 9
(1) extract Fructus Hippophae crude extract: identical with embodiment 1;
(2) extract Fructus Hippophae extract: identical with embodiment 1;
(3) the two phonetic preparations of compound hippophae rhamnoides:
(I) prescription composition (1000 tablet recipe amount)
Fructus Hippophae extract: 500g
Dipyridamole: 30g
Starch 50g
Sucrose: 50g
Magnesium stearate: 5g
Binding agent: 75% appropriate amount of ethanol
(II) preparation process: identical with embodiment 1.
Although above with a general description of the specific embodiments, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (8)
1. two phonetic an of compound hippophae rhamnoides, is characterized in that: by Fructus Hippophae extract, dipyridamole and diluent, lubricant, binding agent, be prepared from, the weight ratio proportional quantity of described Fructus Hippophae extract, dipyridamole and diluent is 10-50:1-5:2.5-5.
2. two phonetic of compound hippophae rhamnoides according to claim 1, is characterized in that: described diluent is the ratio combination with 1:1 of any one or sugarcane sugar and starch in sucrose, starch.
3. two phonetic of compound hippophae rhamnoides according to claim 1, is characterized in that: described lubricant is magnesium stearate.
4. two phonetic of compound hippophae rhamnoides according to claim 1, is characterized in that described binding agent is 75% ethanol.
5. the preparation method of two phonetic an of compound hippophae rhamnoides, comprise the steps: to extract Fructus Hippophae crude extract from Fructus Hippophae, ethanol essence by concentration expressed in percentage by volume more than 95% is carried crude extract, extract, dipyridamole and diluent are pulverized and sieved processing, supplementary material after treatment adds binding agent and in mixer-granulator, stirs and make soft material, soft material is sent in Multifunction granulating machine and is granulated, it is dry that the wet grain of gained is evenly sent into ebullated dryer, the granule being dried adds lubricant and mixes in mixer, tabletting, coating, packs and get final product; Described Fructus Hippophae crude extract adopts circumfluence method to extract: get fresh Fructus Hippophae, squeeze extracting juice after choosing clean foreign material, filter fruit juice filtrate for subsequent use; Marc adds 70% alcohol reflux, and extracting solution merges with filtrate after reclaiming ethanol, and after merging, filtrate is concentrated into 1/3～1/5 of original volume; Filter, filtrate is through macroporous resin adsorption, ethanol elution, and eluent is concentrated into without alcohol taste, adds the purified water of 1～2 times of Fructus Hippophae weight, stirs cooling rear standing filtration, the concentrated cream of receiving of filtrate, vacuum drying to water content is below 6%, pulverizes.
6. the preparation method of two phonetic of compound hippophae rhamnoides according to claim 5, it is characterized in that: more than 95% ethanol of the concentration expressed in percentage by volume that adds 5-8 times of weight in Fructus Hippophae crude extract, stirring and dissolving, after centrifugalize, be concentrated into without alcohol taste, add concentrated rear medicine liquid volume 5-10 purified water doubly, stir cooling, after leaving standstill, get supernatant, the concentrated cream of receiving after centrifugalize, vacuum drying below 5%, is pulverized for subsequent use to water content.
7. the preparation method of two phonetic of compound hippophae rhamnoides according to claim 5, is characterized in that: diluent is that mixing use and the weight ratio of sugarcane sugar and starch is 1:1.
8. the preparation method of two phonetic of compound hippophae rhamnoides according to claim 6, is characterized in that: in every 1000 tablets of medicines, contain Fructus Hippophae extract 400g, dipyridamole 25g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210430554.6A CN102961418B (en) | 2012-11-02 | 2012-11-02 | Compound Hippophae rhamnoides dipyridamole tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210430554.6A CN102961418B (en) | 2012-11-02 | 2012-11-02 | Compound Hippophae rhamnoides dipyridamole tablet and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102961418A CN102961418A (en) | 2013-03-13 |
| CN102961418B true CN102961418B (en) | 2014-06-11 |
Family
ID=47792037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210430554.6A Expired - Fee Related CN102961418B (en) | 2012-11-02 | 2012-11-02 | Compound Hippophae rhamnoides dipyridamole tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102961418B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272081A (en) * | 2018-01-23 | 2018-07-13 | 江苏道诚生物科技有限公司 | A kind of sea-buckthorn composite vitamin piece and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108851071A (en) * | 2018-09-17 | 2018-11-23 | 青海清华博众生物技术有限公司 | Sea-buckthorn VP alimentation composition and its preparation method and application |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1247101C (en) * | 2003-08-23 | 2006-03-29 | 高小平 | Hippophae rhamnoides tea and its preparation |
| CN101428030A (en) * | 2007-11-06 | 2009-05-13 | 沈阳正丰生物技术有限公司 | Compound dipyridamole/acetophen sustained-release capsule and preparation thereof |
-
2012
- 2012-11-02 CN CN201210430554.6A patent/CN102961418B/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272081A (en) * | 2018-01-23 | 2018-07-13 | 江苏道诚生物科技有限公司 | A kind of sea-buckthorn composite vitamin piece and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102961418A (en) | 2013-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1463412B1 (en) | Composition comprising wenguanguo extracts, methods for preparing same and uses therof | |
| RU2349337C2 (en) | Pharmaceutical composition including steroid saponins, method of obtainment, and application | |
| KR20070027532A (en) | Traditional chinese medicine preparation for cardio-cerebral blood vessel diseases and its preparing method | |
| JP2009514960A (en) | Herbal extract powder and its preparation and use | |
| CN102228506A (en) | Composition of malaytea scurfpea extract as well as preparation method and use thereof | |
| JP2016532724A (en) | Medical composition of seed extract of Emblica officinalis and method for its preparation | |
| WO2008007063A2 (en) | Anti-obesity product and it's method of preparation | |
| WO2008145064A1 (en) | The method for a sequoyitol-containing extract obtaining from the genus of trifolium, sobyean and ginkgo biloba and use thereof | |
| KR101827609B1 (en) | Making Method of Red Ginseng Tablet | |
| CN102961418B (en) | Compound Hippophae rhamnoides dipyridamole tablet and preparation method thereof | |
| CN101254217B (en) | Preparation of extract of regeneratabl portion of yew and applications of same for preparing oral anti-cancer medicine | |
| CN1265911A (en) | Medicine for treating cardiovascular disease and preparation process thereof | |
| CN104398561A (en) | Medicinal and edible variety composition for preventing and treating alcoholic liver diseases, and its preparation method | |
| CN101214250B (en) | Use of hederagenin and its derivatives in preparing antidepressant product | |
| KR101095357B1 (en) | Processed Ginseng | |
| CN1209155C (en) | Balsam pear products containing multiple hypoglycemic active composition and preparation thereof | |
| CN101642480A (en) | Pseudo-ginseng flower leaf oral tablet with function of reducing fever and preparation method thereof | |
| CN102370677A (en) | Three-flavor sandalwood preparation and preparation method thereof | |
| CN1225259C (en) | A Chinese patent medicines fomula for curing cerebral arteriosclersis and the preparation process thereof | |
| CN106974996B (en) | Purple Chinese yam extract and preparation method and application thereof | |
| CN102000126B (en) | Ginkgo flavone tablet and preparation method thereof | |
| CN101015596A (en) | Chinese patent drug for curing angiocardiopathy and cerebrovascular disease and its preparing method | |
| RU2683643C1 (en) | Method of producing aqueous-alcohol extract of medicinal plants having sedative and hypotensive action | |
| CN1416852A (en) | Active matter for preventing and treating cerebral diseases and promoting intelligence growth and its prepn | |
| CN116458622A (en) | A food prepared from Notoginseng radix, rhizoma Gastrodiae and macadamia nut, and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140611 Termination date: 20141102 |
|
| EXPY | Termination of patent right or utility model |