CN1416852A - Active matter for preventing and treating cerebral diseases and promoting intelligence growth and its prepn - Google Patents
Active matter for preventing and treating cerebral diseases and promoting intelligence growth and its prepn Download PDFInfo
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- CN1416852A CN1416852A CN 01134566 CN01134566A CN1416852A CN 1416852 A CN1416852 A CN 1416852A CN 01134566 CN01134566 CN 01134566 CN 01134566 A CN01134566 A CN 01134566A CN 1416852 A CN1416852 A CN 1416852A
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Abstract
In the present invention, one cerebral active matter is shinyleaf yellowhorn husk extractive obtained via extraction with alcohol and other organic solvent and contains saponin 30-32 wt%, saccharides 15-25%, coarse protein 8-14 wt%, water 7-10 wt% and coarse fat 1-4 wt%, the other cerebral active matter is shinyleaf yellowhorn husk saponin extractive with saponin content over 50 wt%. These two kinds of cerebral active matters can imporve the function of cerebral nerve system and have obvious effects of preventing and treating cerebral ageing and cerebral vascular diseases, improving memory, promoting intelligence growth and treating diseases of cerebral incompetence or disturbance. The preparation process of these two kinds of cerebral active matters are also disclosed.
Description
Technical field
The present invention relates to two kinds of brain active function plant extracts, a kind of is the alcohol extract of shinyleaf yellowhorn fruit shell, and another kind is the thick Saponin of shinyleaf yellowhorn fruit shell.Simultaneously, the invention still further relates to the preparation method of these two kinds of materials.
Background technology
Lignum Xanthoceratis is that Sapindaceae (Sapindaceae) Lignum Xanthoceratis belongs to the plant of (Xanthoceras), Latin literary fame XanthocerassorbifoliaBunge, and popular name is Wen Guanhua again, Wen Guangguo, xanthoceras sorbifolia, the civil official fruit, precipice Fructus Chaenomelis and hila are gloomy to be stepped on (mongolian medicine name) etc.Machaka or dungarunga can reach 8 meters high; Imparipinnate leaf; Raceme, floral white, polygamy; The capsule green, shell is thick, and is wooden, and ripe pitchy ftractures into three lobes, seed pitchy, ovoid, majority.Only originate in China, mainly be distributed in NORTH CHINA, wild or cultivation.Seed contains oils and fats and can reach more than 50% edible.Stem and leaf can be used as medicine, dispelling the wind and dampness pathogens.Seed is used to control enuresis among the people.Domestic existing in the Lignum Xanthoceratis kernel frost (YINIAOTING crude drug) produced of Pharma Inc. of section, and the alcohol extract of Lignum Xanthoceratis kernel frost, but shell generally all is used as faggot and burns, and wastes very much also contaminated environment; In addition, the alcohol extract technology of known kernel frost is more loaded down with trivial details, time-consuming, is further improved, and in the hope of reducing cost, enhances productivity.
Summary of the invention
The object of the present invention is to provide two kinds of brain active function materials that extract from shinyleaf yellowhorn fruit shell (comprising fruit stem).The cerebral nervous system function can be reconciled and improve to brain active function material provided by the present invention, to control brain aging and cerebrovascular, promote memory and tap intellectual resources, the treatment nocturia, frequent micturition and retarded, senile dementias etc. are because brain function is unsound or the caused disease of obstacle all has remarkable result.The extract that it is characterized in that the shell (comprising fruit stem) that described brain active function material is a Lignum Xanthoceratis.
One of them is the shell of the Lignum Xanthoceratis organic flux extracts such as alcohols of (comprising fruit stem), mainly contains Saponin and other material, and concrete content is as follows:
Saponin sugar crude protein water crude fat other
30-32 15-25 8-14 7-10 1-4 is surplus
Production is carried out according to the following step:
A. the Lignum Xanthoceratis of gathering is cleaned shell, drying;
B. pulverize shinyleaf yellowhorn fruit shell;
C. with organic solvent lixiviate shinyleaf yellowhorn fruit shell powder such as alcohols;
D. reclaim solvent, concentrate fluid extract;
E. dry, sterilize extractive with organic solvent such as alcohol.
Extractive with organic solvent such as Lignum Xanthoceratis alcohol can be made into the conciliation of various dosage forms and improve the medicine of cerebral nervous system function.This medicine is higher than in the current similar medicine any to the curative effect total effective rate of enuresis, be the most effective choice drug at present.Simultaneously, it also can prevent and treat brain aging and cerebrovascular, promotes memory and tap intellectual resources, treatment frequent micturition and dull-witted retarded etc. because unsound or caused other disease of obstacle of brain function.
Extract provided by the invention is the extractive with organic solvent such as alcohol of shinyleaf yellowhorn fruit shell, and is all different with Lignum Xanthoceratis kernel frost (YINIAOTING crude drug) and alcohol extract thereof that Pharma Inc. of middle section produces.The content of its bunkankasaponin (30-32%) is much higher than Lignum Xanthoceratis kernel frost (2-4%), also is higher than its alcohol extract (10-19% sees Table 1).Therefore, do the similar Drug therapy enuresis of feedstock production with extract provided by the invention, not only effective but also dose only is the sixth of YINIAOTING, promptly one day three times, one time one.Make things convenient for patient, reduced the misery that patient takes medicine, particularly child.Simultaneously, preparation method is also easy than the alcohol extract technology of producing the kernel frost, five step process labor and material saving only, and the alcohol extract of producing the kernel frost is only wanted more than ten steps less: the Lignum Xanthoceratis of 1) gathering, clean seed, drying; 2) peel off and obtain kernel; 3) roll the oily kernel cake that gets; 4) drying is pulverized the kernel cake and is got the kernel powder; 5) further deoil with organic solvent extraction kernel powder; 6) reclaim organic solvent; 7) drying, pulverizing get the kernel frost; 8) molten ethanol extraction kernel frost; 9) reclaim ethanol; 10) drying, sterilize the alcohol extract of kernel frost.Moreover extract shinyleaf yellowhorn fruit shell provided by the invention is a raw material, and shinyleaf yellowhorn fruit shell is only burnt as fuel now, and cost is compared with the seed of kernel frost raw material, reduces a lot, and therefore, the whole production cost has reduced more than 50%.
The comparison of the extract of table 1 shinyleaf yellowhorn fruit shell and kernel frost and alcohol extract thereof
| Saponin | Sugar | Crude protein | Water | Crude fat | Other | |
| ????A | ????30-32 | ????15-25 | ????8-14 | ????7-10 | ????1-4 | Surplus |
| ????B | ????10-19 | ????20-30 | ????15-20 | ????10-15 | ????1-10 | Surplus |
| ????C | ????2-4 | ????- | ????55-65 | ????7-16 | ????1-10 | Surplus |
A: the alcohol extract of shell; B: the alcohol extract of kernel frost; C: kernel frost
Simultaneously, the present invention also provides another conciliation and has improved the brain active function material of cerebral nervous system function, it is characterized in that the thick saponin extract of the shell (comprising fruit stem) that described brain active function material is a Lignum Xanthoceratis.
Technical process is as follows:
A. the Lignum Xanthoceratis of gathering is cleaned shell, drying;
B. pulverize shinyleaf yellowhorn fruit shell;
C. with organic solvent lixiviate shinyleaf yellowhorn fruit shell powder such as alcohols, in organic solvent: the ratio of shell powder 2: 1 (V/W), at room temperature, lixiviate 4-5 time, each 20-35 hour;
D. collect lixiviating solution, carry 2-3 time in 80 ℃ of reflux heats again;
E. collect merge extractive liquid;
F. slough solvent, get fluid extract;
G. dry, sterilization gets ethanol extraction;
H. fluid extract reuse water dissolution, n-butanol extraction;
I. n-butyl alcohol extract gets thick Saponin through chromatographic isolation.
The thick Saponin of gained can be made into various drug forms and health product, or is used for reconciling with the ethanol extract compatibility of Lignum Xanthoceratis and improves cerebral nervous system function and treatment because the unsound or caused disease of obstacle of brain function.The thick Saponin of shinyleaf yellowhorn fruit shell is the further refining thing of shinyleaf yellowhorn fruit shell alcohol extract, contains more Saponin (more than 50%), thereby can be more more superior than alcohol extract at preparation medicine and application facet.
The present invention is to be the plant extract of raw material with the shinyleaf yellowhorn fruit shell, is the medicine of at present best treatment nocturia, through toxicity, and pharmacological testing, without any side effects.Preparation technology is convenient, Saponin yield height, and also cost is low.Below by
Embodiment is described further.
The specific embodiment＜embodiment 1 〉
The preparation method of this example explanation shinyleaf yellowhorn fruit shell alcohol extract:
A. the Lignum Xanthoceratis of gathering is cleaned shell, and drying is pulverized, 10kg shell powder;
B. in ethanol: the ratio of shell powder 2: 1 (v/w), with 20 liters of ethanol lixiviates 4～5 times, each 20～35 hours;
C. collect lixiviating solution, carry 2～3 times in 80 ℃ of reflux heats again, collect merge extractive liquid;
D. slough solvent, get fluid extract;
E. dry, sterilization gets ethanol extraction 140.5g, and ingredient is (by a percent):
Saponin sugar crude protein water crude fat other
31.3 17.2 11.6 9.4 3.9 26.6＜embodiment 2 〉
Embodiment 1 described ethanol extraction amount 50g is softening, and the granulation of sieving is adorned 250 of No. 2 capsules, 30 one bottle.This capsule can be used for treating enuresis and other is because the unsound or caused disease of obstacle of brain function.The treatment enuresis, children's every day three times, each one, 15 days one courses of treatment, one to three course of treatment.＜embodiment 3 〉
With embodiment 1 described ethanol extraction amount 50g, sieve and make powdery, add glucose powder 450g and be mixed, granulate, drying, 250 bags in dress 2.0g bag is a kind of enuresis and other granule unsound owing to brain function or the caused disease of obstacle for the treatment of.The treatment enuresis, children's every day three times, each one bag, 15 days one courses of treatment, one to three course of treatment.＜embodiment 4 〉
With embodiment 1 described ethanol extraction amount 40g, sieve and make powder, add the 0.8g dried starch, 0.4g Pulvis Talci and a little ethanol, mixing, tabletting, sterilization, make 200 in every tablet of tablet that contains the 200mg medicament, be and a kind ofly treat enuresis and other is because brain function is unsound or the tablet of the caused disease of obstacle.The treatment enuresis, children's every day three times, each a slice, 15 days one courses of treatment, one to three course of treatment.＜embodiment 5 〉
The preparation method of the thick Saponin of this example explanation shinyleaf yellowhorn fruit shell:
A. the Lignum Xanthoceratis of gathering is cleaned shell, and drying is pulverized, 10kg shell powder;
B. in ethanol: the ratio of shell powder 2: 1 (v/w), with 20 liters of ethanol lixiviates 4-5 time, each 20-35 hour;
C. collect lixiviating solution, carry 2～3 times in 80 ℃ of reflux heats again;
D. collect merge extractive liquid;
E. slough solvent, get fluid extract;
F. dry, sterilization gets ethanol extraction 281.6g;
G. fluid extract reuse water dissolution, n-butanol extraction;
H. n-butyl alcohol extract reuse water dissolution, n-butanol extraction, n-butanol extract;
I. n-butanol extract gets the thick Saponin of 21.6g through drop counter current chromatography.＜embodiment 6 〉
With the thick Saponin 9.0g of embodiment 5 described n-butanol extracts, add proper amount of dry starch, Pulvis Talci and a little ethanol, mixing, tabletting, sterilization, make every 250 of 200mg, be a kind of enuresis and other tablet unsound owing to brain function or the caused disease of obstacle for the treatment of.The treatment enuresis, children's every day three times, each a slice, 15 days one courses of treatment, one to three course of treatment.＜embodiment 7 〉
With embodiment 5 described Saponin 9.0g, adorn 250 of No. 2 capsules, 30 one bottle.This capsule can be used for treating enuresis and other is because the unsound or caused disease of obstacle of brain function.The treatment enuresis, children's every day three times, each one, 15 days one courses of treatment, one to three course of treatment.
Claims (16)
1, a kind of brain active function material, can be used for making and control brain aging and cerebrovascular, promote intelligence, the treatment nocturia, frequent micturition and retarded, senile dementias etc. are because brain function is unsound or the health product or the medicine of the caused disease of obstacle, and it is characterized in that: the shell that described brain active function material is a Lignum Xanthoceratis comprises the extract of fruit stem.
2, brain active function material according to claim 1, it is characterized in that: described material is the organic flux extracts such as alcohols that the shell of Lignum Xanthoceratis comprises fruit stem, it mainly contains bunkankasaponin and other material, concrete form and percentage composition as follows: the sugared crude protein water of Saponin crude fat other
30-32 15-25 8-14 7-10 1-4 surplus.
3, the method for the described brain active function of a kind of production claim 2 material is characterized in that: produce and carry out according to the following step:
A. the Lignum Xanthoceratis of gathering is cleaned shell, drying;
B. pulverize shinyleaf yellowhorn fruit shell;
C. with organic solvent lixiviate shinyleaf yellowhorn fruit shells such as alcohols;
D. reclaim solvent and get fluid extract;
E. dry, sterilize extractive with organic solvent such as alcohol.
4, the method for production brain active function material according to claim 3 is characterized in that: the Lignum Xanthoceratis of gathering among the step a carried out in 8～October.
5, the method for production brain active function material according to claim 3 is characterized in that adopting following method with organic solvent lixiviate shinyleaf yellowhorn fruit shells such as alcohols among the step c:
A. the shinyleaf yellowhorn fruit shell after pulverizing is with organic solvent mercerations such as alcohols, and said organic solvent comprises ethanol, methanol or light gasoline etc.;
B. in organic solvents such as ethanol classes: the shell powder is the ratio of 2: 1 (V/W), lixiviate at room temperature 4～5 times; Each 20～35 hours;
C. collect lixiviating solution, carry 2～3 times in 80 ℃ of reflux heats again;
D. collect merge extractive liquid;
E. slough solvent, get fluid extract;
F. dry, sterilization gets ethanol extraction.
6, with the described brain active function of claim 1 material preparation control brain aging and cerebrovascular, promote intelligence, the treatment nocturia, retarded, senile dementias etc. are because brain function unsound or the health product of the caused disease of obstacle or the method for medicine is characterized in that the extract clear paste is made various dosage forms, and these dosage forms comprise electuary, tablet, syrup or capsule etc.
7, with the described brain active function of claim 1 material preparation control brain aging and cerebrovascular, promote intelligence, the treatment nocturia, frequent micturition and retarded, senile dementias etc. are because brain function unsound or the health product of the caused disease of obstacle or the method for medicine, it is characterized in that with the extract clear paste further with vitamin B, D, compatibilities such as K are made various dosage forms, and these dosage forms comprise electuary, tablet, syrup or capsule.
8, with the described brain active function of claim 1 material preparation control brain aging and cerebrovascular, promote intelligence, treatment nocturia, frequent micturition and retarded, senile dementias etc. are because brain function unsound or the health product of the caused disease of obstacle or the method for medicine, it is characterized in that further and Cordyceps Radix Ginseng, Semen Ginkgo with the extract clear paste, SONGGUOJU etc. and extract compatibility are made various dosage forms, these dosage forms comprise electuary, tablet, syrup or capsule.
9, with the described brain active function of claim 1 material preparation control brain aging and cerebrovascular, promote intelligence, the treatment nocturia, frequent micturition and retarded, senile dementia etc. be because brain function unsound or the health product of the caused disease of obstacle or the method for medicine, it is characterized in that with the extract clear paste further with serrate clubmoss herb alkali A, compatibilities such as antioxidant are made various dosage forms, these dosage forms comprise electuary, tablet, syrup or capsule.
10, with the described brain active function of claim 1 material preparation control brain aging and cerebrovascular, promote intelligence, the treatment nocturia, frequent micturition and retarded, senile dementias etc. are because brain function unsound or the health product of the caused disease of obstacle or the method for medicine, it is characterized in that further and folic acid the extract clear paste, creatine, and compatibility such as each seed amino acid makes various dosage forms, these dosage forms comprise electuary, tablet, syrup or capsule.
11, with the described brain active function of claim 1 material preparation control brain aging and cerebrovascular, promote intelligence, the treatment nocturia, frequent micturition and dull-witted retarded etc. because brain function unsound or the health product of the caused disease of obstacle or the method for medicine, it is characterized in that the extract clear paste is further dosed the thing compatibility with fiber makes various dosage forms, these dosage forms comprise electuary, tablet, syrup or capsule.
12, a kind of brain active function material, can be used for making control brain aging and cerebrovascular, promote intelligence, the treatment nocturia, frequent micturition and retarded, senile dementias etc. are because the health product or the medicine of the unsound or caused disease of obstacle of brain function, it is characterized in that shell that described brain active function material is a Lignum Xanthoceratis comprises the thick saponin extract of fruit stem.
13, brain active function material according to claim 12, it is characterized in that: described material is the thick saponin extract that the shell of Lignum Xanthoceratis comprises fruit stem, mainly contains the bunkankasaponin more than 50%.
14, the method for the described brain active function of a kind of production claim 12 material is characterized in that, produces and carries out according to the following step:
A. the Lignum Xanthoceratis of gathering is cleaned shell, drying;
B. pulverize shinyleaf yellowhorn fruit shell;
C. with organic solvent lixiviate shinyleaf yellowhorn fruit shell powder such as alcohols, in organic solvent: the ratio of shell powder 2: 1 (V/W), at room temperature, lixiviate 4～5 times, each 20～35 hours;
D. collect lixiviating solution, carry 2～3 times in 80 ℃ of reflux heats again;
E. collect merge extractive liquid;
F. slough solvent, get fluid extract;
G. dry, sterilization gets ethanol extraction;
H. fluid extract reuse water dissolution, n-butanol extraction;
I. n-butyl alcohol extract gets thick Saponin through chromatographic isolation.
15, with the described brain active function of claim 12 material preparation control brain aging and cerebrovascular, promote intelligence, the treatment nocturia, frequent micturition and retarded, senile dementias etc. are because brain function unsound or the health product of the caused disease of obstacle or the method for medicine is characterized in that the extract clear paste is made various dosage forms, and these dosage forms comprise electuary, tablet, syrup or capsule.
16, with the described brain active function of claim 12 material preparation control brain aging and cerebrovascular, promote intelligence, the treatment nocturia, frequent micturition and retarded, senile dementias etc. are because brain function unsound or the health product of the caused disease of obstacle or the method for medicine, it is characterized in that with the extract clear paste further with vitamin B, D, K, folic acid, creatine, each seed amino acid, serrate clubmoss herb alkali A, antioxidant, Cordyceps, Radix Ginseng, Semen Ginkgo, SONGGUOJU etc. and extract, compatibilities such as fiber are made various dosage forms, and these dosage forms comprise electuary, tablet, syrup or capsule.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01134566 CN1416852A (en) | 2001-11-06 | 2001-11-06 | Active matter for preventing and treating cerebral diseases and promoting intelligence growth and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01134566 CN1416852A (en) | 2001-11-06 | 2001-11-06 | Active matter for preventing and treating cerebral diseases and promoting intelligence growth and its prepn |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007079695A1 (en) * | 2006-01-12 | 2007-07-19 | Liu Shujun | An extract of xanthoceras sorbifolia bunge and extraction and uses thereof |
| CN102796162A (en) * | 2012-09-04 | 2012-11-28 | 山东理工大学 | Method for extracting xanthoceras sorbifolia bunge husk saponins |
| CN103989371A (en) * | 2014-05-12 | 2014-08-20 | 师海全 | Health caring pillow containing shiny-leaved yellowhorn shucks |
| CN104922164A (en) * | 2014-12-12 | 2015-09-23 | 中国医科大学 | Composite medicine preparation for treating alzheimer disease |
-
2001
- 2001-11-06 CN CN 01134566 patent/CN1416852A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007079695A1 (en) * | 2006-01-12 | 2007-07-19 | Liu Shujun | An extract of xanthoceras sorbifolia bunge and extraction and uses thereof |
| CN102796162A (en) * | 2012-09-04 | 2012-11-28 | 山东理工大学 | Method for extracting xanthoceras sorbifolia bunge husk saponins |
| CN103989371A (en) * | 2014-05-12 | 2014-08-20 | 师海全 | Health caring pillow containing shiny-leaved yellowhorn shucks |
| CN103989371B (en) * | 2014-05-12 | 2017-01-04 | 甘肃长瑞文冠果产业发展有限公司 | A kind of health-care pillow containing shinyleaf yellowhorn shell |
| CN104922164A (en) * | 2014-12-12 | 2015-09-23 | 中国医科大学 | Composite medicine preparation for treating alzheimer disease |
| CN104922164B (en) * | 2014-12-12 | 2020-06-02 | 中国医科大学 | Pharmaceutical composite preparation for treating Alzheimer disease |
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