CN1092991A - A kind of medicine that improves brain function and preparation method thereof - Google Patents
A kind of medicine that improves brain function and preparation method thereof Download PDFInfo
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- CN1092991A CN1092991A CN 93111010 CN93111010A CN1092991A CN 1092991 A CN1092991 A CN 1092991A CN 93111010 CN93111010 CN 93111010 CN 93111010 A CN93111010 A CN 93111010A CN 1092991 A CN1092991 A CN 1092991A
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Abstract
A kind of curable substance mental retardation and dementia and enuresis that improves brain function, described medicine is the alcohol extract of shinyleaf yellowhorn fruit, and concrete content is: crude fat crude protein Saponin candy water other surplus 1～10 15～20 10～20 2.0～30 10～15
Improve the brain function medicine and can improve the cerebral nervous system function comprehensively, diseases such as mental retardation of children and person in middle and old age's dementia are had obvious curative effects.
Description
The present invention relates to Chinese medicine, particularly a kind of medicine of the raising brain function that makes with the shinyleaf yellowhorn fruit extract.
Lignum Xanthoceratis is a Sapindaceae Lignum Xanthoceratis platymiscium, have another name called the precipice Fructus Chaenomelis, belong to machaka or dungarunga, imparipinnate leaf, raceme, floral white, capsule three lobe types, the seed majority, through bright to the sub-Chemical Analysis of Wire Rod of Lignum Xanthoceratis, it contains 60% the oils and fats of having an appointment, about 26% protein, about 1.2% thick Saponin, 2.4% moisture content and other composition of 4.9%, the past is wild plant, there is cultivation recent northern some areas, its adaptability is strong, and is cold-resistant, drought-enduring, impoverishment tolerant, generally the utilization to Lignum Xanthoceratis mostly is two aspects, the first is checked winds and fixed drifting sand, it two is to squeeze edible oil with its seed, and through consulting relevant document both at home and abroad, finding " does not all have medicinal record to Lignum Xanthoceratis in the medicinal book on Chinese herbal medicine of Chinese pharmacopoeia and successive dynasties.
The object of the present invention is to provide a kind of medicine that improves brain function.
The medicine of raising brain function provided by the present invention can be treated enuresis, mental retardation and dementia etc. because the low caused disease of brain function is characterized in that described medicine is the extract of shinyleaf yellowhorn fruit.
One of them is the skimmed milk of Lignum Xanthoceratis kernel, contains crude fat, the crude protein of forming by 17 seed amino acids (as glutamic acid, lysine, arginine, tyrosine etc.), Saponin, water,
Concrete content is:
Crude fat crude protein Saponin water other
Surplus in the of 1～10 55～65 2～4 7～10
Production process is carried out according to following step:
-press kernel cake powder in advance;
-extraction defat;
-drying is pulverized, and sieves, sterilize skimmed milk.
Wherein extract defat and can adopt following manner:
-with weakly polar organic solvent such as petroleum ether, benzene, n-hexane equal under the room temperature or＜90 ℃ of situations of heating under, extraction;
-collect extract, remove desolvate the defat coarse powder.
Perhaps adopt supercritical CO
2
Can make the capsule or the granule of treatment enuresis with Lignum Xanthoceratis kernel skimmed milk.
Shinyleaf yellowhorn fruit and YINIAOTING capsule and granule be to the cure rate evident in efficacy 75% of enuresis, improvement rate 18%, and total effective rate reaches 93%, is ideal a kind of in this type of medicine at present.Simultaneously, YINIAOTING capsule or granule can also be treated mental retardation and dementia.
The present invention also provides a kind of curable substance mental retardation and dementia and enuresis that improves brain function, and described medicine is the alcohol extract of shinyleaf yellowhorn fruit, and concrete content is:
Crude fat crude protein Saponin candy water other
Surplus in the of 1～10 15～20 10～20 20～30 10～15
Technical process is as follows:
Lixiviates such as shinyleaf yellowhorn fruit the after-squeezing or Lignum Xanthoceratis skimmed milk usefulness alcohol organic solvent such as ethanol, methanol, n-butyl alcohol;
-collect lixiviating solution, remove and desolvate, sterilize the alcohol extract clear paste.Can make electuary or tablet with described extract clear paste.Improve the brain function medicine and can improve the cerebral nervous system function comprehensively, diseases such as mental retardation of children and person in middle and old age's dementia are had obvious curative effects.The present invention is that raw material extracts medicine with the shinyleaf yellowhorn fruit, show through various pharmacological testings, without any side effects, preparation technology is simple for Lignum Xanthoceratis kernel skimmed milk, Saponin yield height, cost are low, contain 60% oils and fats in the fruit, contain 17 seed amino acids, the oils and fats of taking off can be used as edible oil and senior paint etc.Be described in detail the present invention below by embodiment.
Embodiment 1
The 1kg Lignum Xanthoceratis seed of gathering, clean, drying is peelled off kind of a skin and is got the 440g kernel, presses kernel in advance and gets the cake powder, at room temperature press normal hexane with normal hexane: cake powder=lixiviate in 1: 14 to 5 times, each 24～48 hours, collect lixiviating solution, remove with distillation under vacuum and desolvate, drying and crushing sieve sterilize the 176g skimmed milk, composition is:
Crude fat crude protein Saponin water other
5.4 61 3.3 7.5 22.8
Embodiment 2
Example 1 described skimmed milk 76g is added an amount of ethanol become soft material, the granulation of sieving, the heat drying granulate that sieves is adorned 380 of No. 2 capsules.This capsule is the YINIAOTING capsule of treatment enuresis.
Embodiment 3
With example 1 described skimmed milk 100g, add the 400g cane sugar powder and be mixed, granulate, drying, sterilization, 50 in dress 10g bag is a kind of YINIAOTING granule.
Embodiment 4
The 1kg Lignum Xanthoceratis seed of gathering gets the 170g skimmed milk by example 1 described step, and composition is:
Crude fat crude protein Saponin water other
6.2 59 3.5 8.2 23.1
Embodiment 5
With example 4 gained skimmed milk, press ethanol: skimmed milk=lixiviate in 2: 1 3～4 times, each 16 to 32 hours, collect lixiviating solution, remove and desolvate, sterilization gets ethanol extraction 25.5g, and composition is:
Crude fat crude protein Saponin candy water other
8.0 15.6 19.2 23.5 14.1 19.6
Embodiment 6
The Lignum Xanthoceratis seed 1kg identical in quality with embodiment 4 that gather cleans drying, the squeezing oil removing, the 750g cake, with 2 times methanol lixiviates 3～4 times, each 20～40 hours, collect lixiviating solution except that desolvating, sterilize methanolic extract 80g, composition:
Crude fat crude protein Saponin candy water other
6.1 17.1 12.3 20.5 12.6 31.4
Embodiment 7
With example 5 gained ethanol extraction clear paste 10g, add 0.2g dried starch, 0.06g50% ethanol and 0.1g Pulvis Talci, mixing, tabletting, sterilization gets 60 tablets of 200mg sheet.Can treat enuresis, mental retardation and dementia.
Embodiment 8
6 gained methanolic extract clear paste 10g add the 32g cane sugar powder with example, the mixed pelletization drying, and sterilization, 4 in dress 10g bag can be treated enuresis, mental retardation and dementia.
Claims (4)
1, a kind of medicine that improves brain function can be treated enuresis, mental retardation and dementia, it is characterized in that described medicine is the alcohol extract clear paste of shinyleaf yellowhorn fruit, mainly contain crude fat,
Crude fat crude protein Saponin candy water other
Surplus in the of 1～10 15～20 10～20 20～30 10～15
2, the method for the described medicine of a kind of production claim 1 is characterized in that technical process is as follows:
Lixiviates such as Lignum Xanthoceratis seed the after-squeezing or Lignum Xanthoceratis kernel skimmed milk usefulness alcohol organic solvent such as ethanol, methanol, n-butyl alcohol;
-collect lixiviating solution, remove and desolvate, sterilize the alcohol extract clear paste.
3,, it is characterized in that described medicine can make electuary by the described medicine of claim 1.
4,, it is characterized in that described medicine can make tablet by the described medicine of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111010A CN1052636C (en) | 1993-03-29 | 1993-03-29 | Medicine for raising brains function and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111010A CN1052636C (en) | 1993-03-29 | 1993-03-29 | Medicine for raising brains function and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1092991A true CN1092991A (en) | 1994-10-05 |
| CN1052636C CN1052636C (en) | 2000-05-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93111010A Expired - Lifetime CN1052636C (en) | 1993-03-29 | 1993-03-29 | Medicine for raising brains function and its preparing method |
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| CN (1) | CN1052636C (en) |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2335599A (en) * | 1998-03-26 | 1999-09-29 | Phytopharm Plc | Treatment of conditions characterised by a deficiency in the number and function of membrane bound receptors using saponins and sapogenins |
| US6391310B1 (en) * | 1996-03-13 | 2002-05-21 | Archer Daniels Midland Company | Method of preparing and using isoflavones for the treatment of neurological symptoms |
| WO2003017919A2 (en) | 2001-08-31 | 2003-03-06 | Fountain Silver Limited | Composition comprising wenguanguo extracts, methods for preparing same and uses therof |
| US7138427B2 (en) | 1999-03-26 | 2006-11-21 | Phytopharm Plc. | 5-β-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia |
| WO2007079695A1 (en) | 2006-01-12 | 2007-07-19 | Liu Shujun | An extract of xanthoceras sorbifolia bunge and extraction and uses thereof |
| US7262285B2 (en) | 2003-10-09 | 2007-08-28 | Pacific Arrow Limited | Anticancer biangeloyl saponins |
| CN100346805C (en) * | 2001-10-31 | 2007-11-07 | 杨柏珍 | Xanthoceras sorbifolia bunge shell extract for treating cerebral hypofunction and anti-diabetic activity |
| US7488753B2 (en) | 2003-10-09 | 2009-02-10 | Pacific Arrow Limited | Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof |
| US7514412B2 (en) | 2003-10-09 | 2009-04-07 | Pacific Arrow Limited | Anticancer biangeloyl saponins |
| US7727561B2 (en) | 2001-08-31 | 2010-06-01 | Pacific Arrow Limited | Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof |
| US8586719B2 (en) | 2005-04-27 | 2013-11-19 | Pacific Arrow Limited | Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents |
| US8614197B2 (en) | 2003-10-09 | 2013-12-24 | Pacific Arrow Limited | Anti-tumor compounds with angeloyl groups |
| US8735558B2 (en) | 2005-02-14 | 2014-05-27 | Pacific Arrow Limited | Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof |
| US8785405B2 (en) | 2010-07-16 | 2014-07-22 | Pacific Arrow Limited | Compounds for treating cancer and other diseases |
| US9382285B2 (en) | 2004-09-07 | 2016-07-05 | Pacific Arrow Limited | Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells |
| US9884884B2 (en) | 2004-07-07 | 2018-02-06 | Baizhen Yang | Compound extracted from husk and fruit stem of xanthoceras sobifolia and its extracting method and use thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012006865A1 (en) * | 2010-07-16 | 2012-01-19 | 哈尔滨三乐生物工程有限公司 | Use of xanthoceras sorbifolia and xanthoceras sorbifolia extract in preparing medicaments for curing urinary incontinence or overactive bladder |
-
1993
- 1993-03-29 CN CN93111010A patent/CN1052636C/en not_active Expired - Lifetime
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6391310B1 (en) * | 1996-03-13 | 2002-05-21 | Archer Daniels Midland Company | Method of preparing and using isoflavones for the treatment of neurological symptoms |
| GB2335599A (en) * | 1998-03-26 | 1999-09-29 | Phytopharm Plc | Treatment of conditions characterised by a deficiency in the number and function of membrane bound receptors using saponins and sapogenins |
| GB2335599B (en) * | 1998-03-26 | 2001-08-01 | Phytopharm Plc | Membrane-bound receptors and their function; cognitive disfunction; treatments therefor; and compositions for use in such treatments |
| US7507720B2 (en) | 1998-03-26 | 2009-03-24 | Phytopharm Plc | 5-Beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia |
| US7138427B2 (en) | 1999-03-26 | 2006-11-21 | Phytopharm Plc. | 5-β-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia |
| US7189420B2 (en) | 2001-08-31 | 2007-03-13 | Fountain Silver Limited | Composition comprising wenguanguo extracts, methods for preparing same and uses thereof |
| WO2003017919A2 (en) | 2001-08-31 | 2003-03-06 | Fountain Silver Limited | Composition comprising wenguanguo extracts, methods for preparing same and uses therof |
| US7727561B2 (en) | 2001-08-31 | 2010-06-01 | Pacific Arrow Limited | Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof |
| CN100346805C (en) * | 2001-10-31 | 2007-11-07 | 杨柏珍 | Xanthoceras sorbifolia bunge shell extract for treating cerebral hypofunction and anti-diabetic activity |
| US7488753B2 (en) | 2003-10-09 | 2009-02-10 | Pacific Arrow Limited | Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof |
| US7514412B2 (en) | 2003-10-09 | 2009-04-07 | Pacific Arrow Limited | Anticancer biangeloyl saponins |
| US7262285B2 (en) | 2003-10-09 | 2007-08-28 | Pacific Arrow Limited | Anticancer biangeloyl saponins |
| US8614197B2 (en) | 2003-10-09 | 2013-12-24 | Pacific Arrow Limited | Anti-tumor compounds with angeloyl groups |
| US9884884B2 (en) | 2004-07-07 | 2018-02-06 | Baizhen Yang | Compound extracted from husk and fruit stem of xanthoceras sobifolia and its extracting method and use thereof |
| US10160780B2 (en) | 2004-07-07 | 2018-12-25 | Baizhen Yang | Compound extracted from husk and fruit stem of Xanthoceras sobifolia and its extracting method and use thereof |
| US9382285B2 (en) | 2004-09-07 | 2016-07-05 | Pacific Arrow Limited | Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells |
| US8735558B2 (en) | 2005-02-14 | 2014-05-27 | Pacific Arrow Limited | Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof |
| US8586719B2 (en) | 2005-04-27 | 2013-11-19 | Pacific Arrow Limited | Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents |
| WO2007079695A1 (en) | 2006-01-12 | 2007-07-19 | Liu Shujun | An extract of xanthoceras sorbifolia bunge and extraction and uses thereof |
| US8785405B2 (en) | 2010-07-16 | 2014-07-22 | Pacific Arrow Limited | Compounds for treating cancer and other diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1052636C (en) | 2000-05-24 |
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