CN102771594A - Antibacterial, inflammation-diminishing, and analgesic Ampelopsis grossedentata preparation and preparation method thereof - Google Patents
Antibacterial, inflammation-diminishing, and analgesic Ampelopsis grossedentata preparation and preparation method thereof Download PDFInfo
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- CN102771594A CN102771594A CN2011101235015A CN201110123501A CN102771594A CN 102771594 A CN102771594 A CN 102771594A CN 2011101235015 A CN2011101235015 A CN 2011101235015A CN 201110123501 A CN201110123501 A CN 201110123501A CN 102771594 A CN102771594 A CN 102771594A
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Abstract
Belonging to the technical field of traditional Chinese medicine and health product processing, the invention relates to an antibacterial, inflammation-diminishing, and analgesic Ampelopsis grossedentata preparation and a preparation method thereof. The preparation solves the problem of applying single Ampelopsis grossedentata in antibacterium, inflammation diminishing, and analgesia, its effective component utilization rate is high, and the production process is simplified. The preparation method consists of: crushing Ampelopsis grossedentata tender branches and leaves, carrying out water extraction or alcohol extraction one to three times, conducting filtration, combining filtering solutions, adding an organic solvent for separation or directly conducting concentrating to obtain an extract, performing drying, adding auxiliary materials, mixing the materials, conducting granulation and tabletting to obtain tablets or capsules or powder or other oral preparations, or directly preparing the mixture into a beverage.
Description
Technical field
The present invention relates to a kind of antibiotic, anti-inflammatory, analgesic vine tea preparation and preparation method thereof, relate in particular to the extraction and the production method thereof of vine tea active ingredient, belong to Chinese medicine, health products processing technique field.
Background technology
Vine tea is commonly called as Maoyanmei tea, Dragon Boat Festival tea, rattan mother-in-law tea (claiming the sweet tea in mountain, dragon palpus tea again), is (Hand-Mazz) young stem and leaf of W.T.wang of Vitaceae Ampelopsis ampelopsis grossdentata section (Ampelopsis grossedentata).The sweet length of little hardship promotes the production of body fluid to quench thirst; Its flavor is sweet cool in nature, has clearing heat and detoxicating, anti-inflammation, dispels rheumatism, effects such as strengthening the bones and muscles, reducing blood lipid, liver protecting.Prior art just gets into the elementary step to the pharmacological evaluation of vine tea at present; Vine tea there is not the report of detailed antibiotic, anti-inflammatory, ease pain, on existing research and utilization, is mostly compound preparation; Use with other food, Chinese medicine configuration; Do not see that folk prescription uses, result of use is undesirable, has increased cost and uncontrollable composition; To play curative effect to disease, need bigger dosage, and onset time be longer; Patent of the present invention has solved the problem that the vine tea folk prescription is applied in antibiotic, anti-inflammatory, ease pain, and medical value is high, and cost is low, and good effect overcomes the folk prescription vine tea and utilize degree low, the shortcoming that effective component extraction rate is low.
Summary of the invention
To the above-mentioned defective that prior art exists, the present invention aims to provide a kind of use vine tea folk prescription, improves vine tea and utilizes degree, preparation that method for distilling that effective component extraction rate is high and result of use are good and production method.
To achieve these goals, the present invention adopts following technical scheme:
The vine tea browse is pulverized, and through the water or the alcohol extract of vine tea, aqueous extract filters; Merging filtrate further adds organic solvent separation and purification or not with an organic solvent, is condensed into medicinal extract; Add auxiliary material, mix, granulate; Compressing tablet, sugar coating is processed tablet or capsule or electuary (granule) or other oral formulations.The vine tea volatile oil that can add collection among the present invention, the water extraction is employed in room temperature or under the ebuillition of heated condition, carries out, and extraction time is from lacking one to three time, and the consumption of water is not for can have medicinal material at least, and hypervolia is not limit.Alcohol extract carries out at ambient temperature, and extraction time is at least one to three times, and the consumption of alcohol is not for can have medicinal material at least, and amount of ethanol is not too much limit, and ethanol adopts absolute ethyl alcohol or various concentration ethanol.Add organic solvents such as chloroform, ethyl acetate, benzinum, benzinum adopts benzinum-30, benzinum-60 or benzinum-90.
Egg causes the rat paw edema experimental result clearly and shows that vine tea has tangible antiphlogistic effects, and its high dose antiphlogistic effects is compared with the positive drug aspirin does not have notable difference, explains that vine tea preparation of the present invention has significant analgesia role; The in-vitro antibacterial experimental result shows that vine tea preparation of the present invention has the obvious suppression effect to Escherichia coli, staphylococcus aureus, Pseudomonas aeruginosa, salmonella, Shigella Song Shi shigella dysenteriae; The acetic acid twisting experimental result shows, vine tea preparation analgesic effect of the present invention; So this preparation has good antibiotic, anti-inflammatory and analgesic effect.
Beneficial effect of the present invention:
The present invention produces the vine tea preparation that obtains and contains 19 kinds of nutrition and trace elements that human body is necessary; Calcium, iron, content of magnesium height; Angiocardiopathies such as arrhythmia cordis, myocardial ischemia, hypertension, coronary heart disease, atherosclerotic there is prevention effect preferably, osteoporosis is had good health-care effect; The dietary fiber that is rich in, carrotene and vitamin E have prevention effect preferably to cancer; Manganese content is high, and longevity is highly advantageous to; Gram-negative bacteria, influenza first type and B virus all there is inhibitory action; Vine tea preparation of the present invention: easy to use, the consumer can accomplish voluntarily, and dose is little; Curative effect is rapid, and is easy to carry, and quality is more stable; Its production method is simple, and effective component extraction rate is high, and vine tea preparation adult using dosage is equivalent to 6～9 gram Chinese medicines/inferior; Each 2～3 times, possess good antibiotic, anti-inflammatory, analgesia function.
The specific embodiment
Embodiment 1
The vine tea browse is pulverized, and crosses 20 mesh sieves, adds 100 ℃ of water and does not have medicinal material, extracts secondary, and each one hour, filter, merging filtrate and volatile oil add flavouring, add the water pondage, process oral liquid.
Embodiment 2
The vine tea browse is pulverized, and crosses 20 mesh sieves, adds water and does not have medicinal material for 100 ℃, extracts each 1 hour three times; Filter, collect volatile oil simultaneously, merging filtrate, the filtrating evaporate to dryness gets brownish black medicinal extract; Medicinal extract adds auxiliary material, adds after the mixing again and collects the volatile oil that obtains, and mixing adds an amount of adhesive well known in the art, and it is dry to granulate; Add lubricant, tablet press machine is pressed into tablet, sugar coating, and packing promptly gets the vine tea tablet; Can the particle of processing be added encapsulated dose of proper amount of lubricating agent; Also but granule is processed in the particle packing.
Embodiment 3
The vine tea browse is pulverized, and crosses 40 mesh sieves, through room temperature water ultrasonic Extraction three times, each 30 minutes, filter, merging filtrate, the filtrating Rotary Evaporators boils off solution, brownish black medicinal extract.Medicinal extract is spray dried to powder, crosses the 100-120 mesh sieve, encapsulated, packing promptly gets capsule.
Embodiment 4
The vine tea browse is pulverized, and without sieving, 60 ℃ of decoctings of warp boil twice, and each one day, filter, merging filtrate, filtrating adds chloroform extraction, leaves standstill, and filtrating is divided into two-layer, water layer and chloroform layer, the layer that anhydrates gets chloroform layer.
Fling to chloroform, get blackish green medicinal extract, medicinal extract adds again collects the volatile oil that obtains, mixing, vacuum drying or normal pressure oven dry (crossing the 80-100 mesh sieve).Add debita spissitudo ethanol and process softwood, the system particle, drying, apply oil, mixing, the tablet press machine compressing tablet becomes tablet, sugar coating, packing promptly gets sugar coated tablet.
Embodiment 5
With embodiment 4, extraction solution is ethanol, and organic solvent changes ethyl acetate, benzinum etc. into.
Embodiment 6
The anti-inflammatory pharmacodynamic study of Ampelopsis grossedentata extrat preparation
1, animal used as test: 60 of SD rats, body weight 130～150g, random packet, 10 every group; If experimental group such as blank, alcohol contrast and the basic, normal, high dosage of vine tea water extract A.
2, sample source and preparation:
(1) embodiment 1 vine tea preparation: the vine tea water extract is condensed into medicinal extract, and amounting to crude drug content is 350mg/ml.
(2) high dose group: vine tea preparation dilution administration (be equivalent to crude drug content 200mg/ml, dosage is equivalent to crude drug 2000mg.kg body weight).
(3) dose groups in: the Ampelopsis grossedentata extrat high dose group adds physiological saline, by dilution back administration (be equivalent to crude drug content 100mg/ml, dosage is equivalent to crude drug 1000mg/kg body weight) in 1: 2.
(4) low dose group: the Ampelopsis grossedentata extrat high dose group, add physiological saline, by dilution in 1: 4, dilution back administration (be equivalent to crude drug content 40mg/ml, dosage is equivalent to crude drug 400mg/kg body weight).
(5) positive thing adopts aspirin: Shijiazhuang, Hebei pharmacy group produces, lot number: 061114.
3, experimental technique: egg causes the influence of rat paw edema clearly
4, experimentation: get 60 of SD rats, body weight 130～150g, every rat is anaesthetized by 1g/kg body weight lumbar injection urethane; Strange portion uses iodine disinfection about each mouse, and after 75% ethanol took off iodine, each cut the long osculum of 1cm; (diameter 6.5mm～8.5mm) implantation is subcutaneous will to be weighed as the sterilization rayon balls of 30mg with the ophthalmology tweezers; Each cotton balls adds penicillin, each 0.1mg of streptomysin (being dissolved in the 0.2mL physiological saline), in case infection, skin suture immediately.All rats are divided into 5 groups at random with 1.4.2, and 12 every group, water 12h is can't help in the rat fasting before the experiment, and postoperative 2h begins by 1mL/100g body weight gastric infusion, and wherein the blank group is given equal-volume distilled water, 1 time/d, is total to 7d.In the 8d kill animals, open former otch, cotton balls is taken out together with connective tissue on every side, wrapped up the cotton balls of granulation tissue around stripping out, reject adipose tissue,, 60 ℃ of baking ovens weigh after placing 12h, and deduct the raw cotton ball weight and be the granuloma net weight.
5, experimental result
Visible by table 1; The granuloma induced by implantation of cotton pellets net weight of the basic, normal, high dose groups of Ampelopsis grossedentata extrat and blank group are relatively; Difference has statistical significance (P＜0.05 or 0.01); Explain that the Ampelopsis grossedentata extrat group can obviously suppress the swollen formation of rat granuloma, the prompting Ampelopsis grossedentata extrat has certain antiinflammatory action.
The influence that table 1 Ampelopsis grossedentata extrat swells to rat granuloma (x ± s, n=10)
Compare with the blank group:
*P＜0.05;
*P＜0.01
Experimental result shows that vine tea has tangible antiphlogistic effects, and its high dose antiphlogistic effects is compared with the positive drug aspirin does not have notable difference.
Embodiment 7
The research of in-vitro antibacterial experiment
1, bacterial classification: Escherichia coli, staphylococcus aureus, Pseudomonas aeruginosa, salmonella, Shigella Song Shi shigella dysenteriae are available from microorganism teaching and research room of Zhongshan University.
2, sample source and processing
(1) vine tea extract: it is 0.5g/mL that the vine tea extract is prepared in crude drug amount concentration.
(2) berberine soup: being prepared into concentration is 0.1g/mL.
3, experimental technique: adopt in-vitro antibacterial method (doubling dilution) to experimentize
4, experimentation:
(1) hatching bacterial classification: get Escherichia coli etc. and be inoculated in the sterilized nutrient broth medium, in 37 ℃ of insulating boxs, cultivate 18h with oese.
(2) dilution of bacterial classification degree: get the bacterial classification after the hatching, be diluted to 200 times.
(3) confirming of liquor strength: carry out doubling dilution.
(4) antibacterial experiment: the bacterium liquid 0.1m1 of the dilution of respectively learning from else's experience is inoculated in respectively in the different experimental group soups; Place 37 ℃ of incubators to cultivate 24h; After therefrom draw 1ml respectively and add in the 9ml broth bouillon to dilute ten times, get this culture medium that contains bacterium and soup and continue to dilute 10～10 with broth bouillon
7Doubly.On the broth bouillon horizontalization ware agar medium that contains bacterium and soup with each concentration of 0.1ml, make 3 plates altogether, with the aseptic rod that is coated with; Gently bacterium liquid is spread out; Be sure not bacterium liquid is run into the edge of plate, plate is put 37 ℃ of medium culture 20h, calculate clump count; Get the clump count scope and carry out clump count at the plate of 30-300 and calculate, calculate according to the extension rate of medicine then and formerly contain clump count in the bacterium soup as result of the test.
5, experimental result:
The result sees table 2.
Table 2 antibacterial tests result (X ± s)
Experimental result shows that this vine tea preparation has tangible antibacterial effect.
Embodiment 8
1, animal used as test: the NIH mouse, the NIH mouse, male and female half and half, the cleaning grade standard, totally 50, by the ordering of body weight size, select the healthy animal of body weight 18～22g for use, be divided into four groups at random, 10 every group.If negative control, high, medium and low three dose groups of positive control and vine tea water extract.
2, sample source and configuration:
(1) embodiment 1 vine tea preparation: vine tea water extract liquid is condensed into medicinal extract, and amounting to crude drug content is 350mg/ml.
(2) high dose group: vine tea preparation dilution administration (be equivalent to crude drug content 200mg/ml, dosage is equivalent to crude drug 2000mg.kg body weight).
(3) dose groups in: the Ampelopsis grossedentata extrat high dose group adds physiological saline, by dilution back administration (be equivalent to crude drug content 100mg/ml, dosage is equivalent to crude drug 1000mg/kg body weight) in 1: 2.
(4) low dose group: the Ampelopsis grossedentata extrat high dose group, add physiological saline, by dilution in 1: 4, dilution back administration (be equivalent to crude drug content 40mg/ml, dosage is equivalent to crude drug 400mg/kg body weight).
(5) positive thing adopts aspirin: Shijiazhuang, Hebei pharmacy group produces, lot number: 061114.
3, experimental technique: acetic acid is to turning round the body experiment
Water 12h is can't help in the mouse fasting before the experiment, respectively organizes mouse then by 0.7mL/20g body weight gastric infusion, and wherein model control group is given equal-volume distilled water.30min after the administration, lumbar injection 0.6% acetum 0.2mL turns round the body number of times in the observed and recorded 30min, and calculates the analgesia rate.
Analgesia rate=[(model group is turned round body number of times one administration group and turned round the body number of times)/model group is turned round the body number of times] * 100%
4, experimental result:
Through statistics, each dose groups analgesia result sees the following form 3.
Each dose groups acetic acid analgesic experiment of table 3 (x ± s, n=10)
Compare * * P＜0.01, P*＜0.05 with model group.
Visible by table 3, compare with normal group, each dosage of vine tea preparation has significant analgesia role.Wherein, the effect and the positive controls of vine tea preparation high dose group are suitable, explain that said preparation has significant analgesia role.
In sum, description of test vine tea preparation of the present invention has good antibiotic, anti-inflammatory and analgesic effect.
According to the announcement and the instruction of above-mentioned specification, those skilled in the art in the invention can also change and revise above-mentioned embodiment.Therefore, the specific embodiment that discloses and describe above the present invention is not limited to also should fall in the protection domain of claim of the present invention modifications more of the present invention and change.In addition, although used some specific terms in this specification, these terms are explanation for ease just, the present invention is not constituted any restriction.
Claims (9)
1. antibiotic a, anti-inflammatory, analgesic vine tea preparation and preparation method thereof; It is characterized in that: the production method of vine tea preparation once may further comprise the steps: the vine tea browse is pulverized, and water is carried or alcohol extracting one to three time; Aqueous extract filters; Merging filtrate is condensed into medicinal extract, processes oral formulations by conventional method.
2. a kind of antibiotic, anti-inflammatory according to claim 1, analgesic vine tea preparation and preparation method thereof; It is characterized in that: vine tea preparation, its raw material are the browses of vine tea, with the water extract of vine tea or alcohol extract as active ingredient; Process pharmaceutical composition, formulation is a peroral dosage form.
3. pharmaceutical composition according to claim 2 is characterized in that: said composition is to add tablet, capsule, granule, oral liquid or the aerosol etc. that acceptable auxiliary is processed on the pharmacy with described active ingredient.
4. pharmaceutical composition according to claim 2 is characterized in that: said vine tea is meant it and just adopts browse or its browse through processing.
5. a kind of antibiotic, anti-inflammatory according to claim 1, analgesic vine tea preparation and preparation method thereof, it is characterized in that: said vine tea preparation raw material is the single of vine tea, or its composition.
6. a kind of antibiotic, anti-inflammatory according to claim 1, analgesic vine tea preparation and preparation method thereof is characterized in that: behind the merging filtrate, add organic solvent extraction, reclaim organic solvent, get organic solvent layer, be condensed into medicinal extract.
7. vine tea preparation according to claim 6 is characterized in that: after being condensed into medicinal extract, add flavouring, add the water pondage, process oral liquid.
8. vine tea preparation according to claim 6 is characterized in that: after being condensed into medicinal extract, add auxiliary material, mix, add the volatile oil of having collected, granulate, add the conventional auxiliary material compressing tablet of tablet, process tablet.
9. a kind of antibiotic, anti-inflammatory according to claim 1, analgesic vine tea preparation and preparation method thereof, it is characterized in that: this oral formulations can be health products or medicine.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104381428A (en) * | 2014-10-20 | 2015-03-04 | 柳州市天姿园艺有限公司 | Fruit and vegetable fresh-keeping method |
| CN104381429A (en) * | 2014-11-25 | 2015-03-04 | 天峨县平昌生态农业有限公司 | Fruit and vegetable preservative containing vine tea extract |
| CN106728484A (en) * | 2017-01-05 | 2017-05-31 | 佛山市恒南医药科技有限公司 | A kind of extraction process of wild rattan mother-in-law tea extraction |
| US9827188B2 (en) | 2015-08-14 | 2017-11-28 | Johnson & Johnson Consumer Inc. | Compositions comprising ampelopsis grossedentata and albizia julibrissin extracts |
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| CN102038190A (en) * | 2009-10-23 | 2011-05-04 | 任启生 | Application of ampelopsin to preparation of anti-mutagenic health-care foods and medicaments |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104381428A (en) * | 2014-10-20 | 2015-03-04 | 柳州市天姿园艺有限公司 | Fruit and vegetable fresh-keeping method |
| CN104381429A (en) * | 2014-11-25 | 2015-03-04 | 天峨县平昌生态农业有限公司 | Fruit and vegetable preservative containing vine tea extract |
| US9827188B2 (en) | 2015-08-14 | 2017-11-28 | Johnson & Johnson Consumer Inc. | Compositions comprising ampelopsis grossedentata and albizia julibrissin extracts |
| US9925136B2 (en) | 2015-08-14 | 2018-03-27 | Johnson & Johnson Consumer Inc. | Methods of reducing signs of skin aging using compositions comprising ampelopsis grossedentata and albizia julibrissin extracts |
| US10004677B2 (en) | 2015-08-14 | 2018-06-26 | Johnson & Johnson Consumer Inc. | Methods of reducing skin inflammation using compositions comprising Ampelopsis grossedentata and Albizia julibrissin extracts |
| CN106728484A (en) * | 2017-01-05 | 2017-05-31 | 佛山市恒南医药科技有限公司 | A kind of extraction process of wild rattan mother-in-law tea extraction |
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Application publication date: 20121114 |