KR101821925B1 - A composition comprising the complex extract of Poncirus trifoliata and Cinnamommum cassia for treating or preventing allergy desmatitis - Google Patents

Abstract

 The present invention relates to a pharmaceutical composition, a health functional food and a cosmetic composition for preventing or treating allergic dermatitis, which comprises a complex extract of fusarium and broiler chickens. The combined extracts of the flaxseed and broiler chicks of the present invention can effectively prevent skin edema induced by an allergenic substance, and thus have an effect of preventing or treating allergic dermatitis.

Description

FIELD OF THE INVENTION The present invention relates to a composition for preventing or treating allergic dermatitis, which comprises a complex extract of Phellinus linteus,

 The present invention relates to a pharmaceutical composition, a health functional food and a cosmetic composition for prevention or treatment of allergic dermatitis including a mixed extract of feces and broiler chickens.

As the environmental pollution is accelerated due to the development of industry, allergens causing various immunological irritable diseases are rapidly increasing, and allergic diseases such as bronchial asthma, rhinitis, allergic conjunctivitis and dermatitis are increasing. Allergies mainly occur in the digestive system, central nervous system and skin, and can be caused by chemicals, drugs and other irritants.

Although corticosteroids and antihistamines are used for the treatment of allergic dermatitis, various side effects have been reported when they are administered over a long period of time. In recent years, studies have been actively conducted to treat allergic dermatitis using extracts extracted from natural plants, rather than chemical agents.

Citrus aurantium L. tangerine, an evergreen tree belonging to the family Rutaceae, is an oily plant of Poncirus trifoliata Rafin. It picks up immature fruit from May to June, transversely divides it into two sides, Lt; / RTI > It has been used as a medicinal herb medicine, and it has been used for the treatment of rosacea, obesity, sari, insomnia and feces.

Examples of the follicle components include essential oils such as limonene, linalool, camphene and the like, pravastatin such as poncirin, naringin, hesperidin, neohesperidin, Coumarins have been reported, such as nodules and umbelliferone, auraptene, imperatorin, and the like. It has been reported that ponchirin has antitumor activity and intestinal bacterial inhibitory action and anti-helicobacter pylori activity, and Naringin has been reported to have cholesterol-inhibiting effect, leukemia cell to normal cell, and inhibition of breast cancer cell proliferation. In addition, water extracts of Fusarium wilt have been reported to stabilize the membranes of intraperitoneal mast cells in anaphylactic model induced by compound 48/80 and to prevent the death of rats due to anaphylactic shock.

Broiler meat is extracted from cinnamomum cassia Presl broth, which is an evergreen tree belonging to Lauraceare, between 8 and 10 months. It has been used as a medicinal medicine for the treatment of boiled pancreas, myrrh and cold blood vessels, and has been used for the treatment of stigmatism, gastrointestinal stomach,

The broiler contains 1 ~ 2% of essential oil, which contains 75 ~ 90% of cinnamaldehyde as main ingredient and contains eugenol and tannin. Broilers have been reported to have antibiotic, antibacterial, antiviral, antioxidant, anticancer, hypotensive, cholesterol and lipid lowering, gastric-protective effects.

Korean Patent Registration No. 10-0981038 discloses a composition for treating atopy and acne, which comprises flax and broiler as a component. According to the patent document, 3 to 6 parts by weight of persimmon, 4 to 8 parts by weight of spearmint, 4 to 10 parts by weight of sorghum persimmon, 4 to 8 parts by weight of citrine, 5 to 12 parts by weight of fern, 4 to 9 parts by weight of gold, 10 to 10 parts by weight of starch, 8 to 15 parts by weight of starch, 4 to 9 parts by weight of licorice, 4 to 9 parts by weight of peony root, 6 to 9 parts by weight of rhizome root, 5 to 9 parts by weight of starchy rape, 2 to 3 parts by weight of rhizome, The mixture extract containing 6 to 12 parts by weight of pine bark, 6 to 15 parts by weight of bamboo shoot, and 3 to 6 parts by weight of bark can treat atopy and acne. To the mixture, 4 to 9 parts by weight of Angelica keiskei, 5 to 15 parts by weight of ginseng, 3 to 9 parts by weight of dandelion, 3 to 9 parts by weight of ginseng, 5 to 15 parts by weight of ginseng, 5 to 15 parts by weight of sulfur, 2 to 5 parts by weight of broth, 2 to 5 parts by weight of health, 6 to 15 parts by weight of gold, 6 to 15 parts by weight of phosphorus and 6 to 15 parts by weight of germanium can be further mixed.

However, the composite composition of the patent document additionally includes an extract of 27 genera herb medicine in addition to fecal and broiler, and it is disclosed that it is possible to treat atopy and acne only when a very large amount of medicines are mixed at a specific ratio, There is no disclosure that it exhibits an excellent allergic dermatitis suppressing reaction even when constituents are constituted.

The inventors of the present invention confirmed that a mixed extract of two herbicidal and herbicidal herb extracts showed excellent allergic dermatitis suppression during the study of natural herb medicine for the development of a new therapeutic agent for treating allergic dermatitis.

Accordingly, an object of the present invention is to provide a pharmaceutical composition for preventing or treating allergic dermatitis, which comprises a mixed extract of fowl and broiler chickens.

It is also an object of the present invention to provide a health functional food for preventing or ameliorating allergic dermatitis containing mixed extracts of fowl and broiler chickens.

Another object of the present invention is to provide a cosmetic composition for improving allergic dermatitis, which comprises a combined extract of fowl and broiler chickens as an active ingredient.

In order to achieve the above object, the present invention provides a pharmaceutical composition for preventing or treating allergic dermatitis, which comprises a combined extract of feces and broiler chickens as an active ingredient.

The present invention also provides a pharmaceutical composition for preventing or treating allergic dermatitis, wherein the complex extract is extracted with water or an alcohol as an extraction solvent.

The present invention also provides a pharmaceutical composition for preventing or treating allergic dermatitis, wherein the combined extract is a mixture of fowl and broiler chick extracts at a weight ratio of 1: 0.5 to 1: 5.

The present invention also provides a pharmaceutical composition for preventing or treating allergic dermatitis, wherein the combined extract is suppressed edema.

The present invention also provides a pharmaceutical composition for preventing or treating allergic dermatitis, wherein the allergic dermatitis is contact dermatitis or atopic dermatitis.

The present invention also provides a health functional food for preventing or ameliorating allergic dermatitis, which comprises a combined extract of feces and broiler chickens as an active ingredient.

The present invention also provides a health functional food for preventing or ameliorating allergic dermatitis, wherein the complex extract is a mixture of foliar and broiler chick extracts at a weight ratio of 1: 0.5 to 1: 5.

The present invention also provides a cosmetic composition for improving allergic dermatitis, which comprises a combined extract of feces and broiler chickens as an active ingredient.

In addition, the present invention provides a cosmetic composition for improving allergic dermatitis, wherein the combined extract is obtained by mixing the extracts of fowl and broiler chickens at a weight ratio of 1: 0.5 to 1: 5.

The mixed extract of the feces and broiler of the present invention can effectively inhibit skin edema induced by an allergen causing substance, and thus has an effect of preventing or treating allergic dermatitis.

FIG. 1 is a graph showing the results of confirming the effect of suppressing ear edema in a combination of foliar and broiler complex extracts, a fibrillar single extract (Comparative Example 1), and a broiler chick single extract (Comparative Example 2) in an atopic dermatitis animal model.

The present invention provides a pharmaceutical composition for the prevention or treatment of allergic dermatitis, which comprises a complex extract of fusarium and broiler chickens.

Since the combined extract of feces and broiler of the present invention is an extract of natural herbal medicine, it is free from cytotoxicity and effectively suppress edema caused by allergic dermatitis.

The combined extract may contain at least one compound selected from the group consisting of water, alcohols, ethyl acetate, glycerin, ethylene glycol, propylene glycol, butylene glycol and mixed solvents thereof (e.g., functional alcohols, hydroglycerin, ), And it is preferably extracted with a solvent selected from water, anhydrous alcohol having 1 to 4 carbon atoms or hydrated alcohol. Here, the alcohol having 1 to 4 carbon atoms may be methanol, ethanol, n-propanol, iso-propanol, n-butanol, iso-butanol or tert-butanol, preferably ethanol.

The ethanol may be 10 to 100% ethanol, preferably 30 or 70% ethanol aqueous solution.

The combined extract may be an extract obtained by mixing the fowl and broiler chickens at a weight ratio of 1: 0.1 to 1:10, preferably 1: 0.5 to 1: 5 by weight.

The complex extract of the present invention may include not only extracts obtained by mixing fowl and broiler chickens, but also extracts obtained by extracting components of fowl and broiler chickens.

As a preferred example, it is preferable that the combined extract is extracted with 30 or 70% ethanol and the single extracts are mixed at a weight ratio of 1: 0.5 to 1: 5.

The combined extract of feces and broiler chickens of the present invention can effectively treat allergic dermatitis. The allergic dermatitis can include without limitation any dermatosis caused by allergy, preferably, contact dermatitis or atopic dermatitis .

The fowl and broiler mixed extracts are preferably prepared by a method comprising the following steps, but are not limited thereto.

(1) drying and finely dividing the feed and broiler chicks;

(2) Extracting the extracted seedlings and broiler chickens with an extraction solvent to obtain an extract;

(3) cooling and extracting the extract;

(4) a step of concentrating and drying the filtered extract

(5) a step of preparing dried ground beef and broiler chick extract in powder form and mixing.

The seedlings and broilers used in step (1) above may be cultivated or marketed without limitation.

The extraction of step (2) may be performed by shaking extraction, Soxhlet extraction, or a reflux extraction method, but is not limited thereto. The extraction temperature is preferably 50 to 120 ° C, more preferably 90 to 95 ° C. In addition, the extraction time is preferably 2 to 5 hours, and the extraction may be performed 1 to 5 times.

The filtration in the step (3) may be performed using 100 to 500 mesh, preferably 100 to 300 mesh.

The filtered extract of step (4) may be subjected to a step of allowing the precipitate to settle by allowing it to stand at room temperature for 1 to 5 days, and may further include a step of filtering the obtained precipitate.

The concentration in the step (4) may be performed at 10 to 100 ° C and may be performed using a vacuum decompression condenser or a vacuum rotary evaporator, and is preferably 10 to 30 brix, preferably 15 brix. In addition, the above-mentioned drying is preferably carried out by vacuum drying, vacuum drying, boiling drying, spray drying or freeze drying, more preferably freeze-drying.

In the present invention, the pharmaceutical composition may be a formulation selected from the group consisting of ointments, gels, creams, patches and sprays. In addition, the above pharmaceutical composition may be an oral preparation or a main ingredient.

The oral preparation may be a powder, granule, tablet, capsule, suspension, emulsion, syrup, aerosol, suspension, solution, emulsion or syrup, and the injectable preparation may be in the form of a sterile injectable preparation.

The pharmaceutical composition of the present invention can be formulated by adding a pharmaceutically acceptable carrier. For formulation, refer to Remington's Pharmaceutical Science (recent edition), Mack Publishing Company, Easton PA. The pharmaceutically acceptable carrier means those conventionally used in the manufacture of a pharmaceutical composition for a person skilled in the art to which the present invention belongs. For example, there may be mentioned lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, Water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, and mineral oil. Pharmaceutically acceptable carriers also include diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrants, surfactants, and the like.

For example, a pharmaceutical carrier and / or excipient suitable for topical administration may be a conventional carrier known to those skilled in the art in connection with the pharmaceutical preparation for skin administration (for example, a skin disease treatment) according to the present invention and / It is preferably an excipient.

Solid formulations for oral administration include tablets, pills, powders, granules, capsules, and the like. Such solid preparations can be prepared by incorporating into the pharmaceutical composition of the present invention at least one or more excipients such as starch, calcium carbonate, sucrose, Lactose, gelatin and the like. In addition to simple excipients, lubricants such as magnesium, stearide, and talc may also be used.

Liquid preparations for oral administration include suspensions, solutions, emulsions and syrups. Various excipients such as wetting agents, sweeteners, fragrances and preservatives may be included in addition to water and liquid paraffin, which are commonly used simple diluents. have.

Examples which may be mentioned for skin administration are suitable for the production of dusting powders, emulsions, suspensions, oils, sprays, ointments, ointments, creams, pastes, gels, foams or solutions, and may be formulated as transdermal therapeutics (TTS) ) And / or excipients. The topical pharmaceutical preparations of the present invention may be semi-solid formulations, in particular ointments (ointments, suspension ointments), creams, gels or pastes. Lactic alcohol, cetyl alcohol, stearyl alcohol, fatty acids such as palmitic acid or stearic acid, liquid or solid paraffin or ozokerite, liquid or solid waxes, for example, For example, isopropyl myristate, natural or partially synthetic fats such as coconut fatty acid triglycerides, hydrogenated oils such as hydrogenated peanut or castor oil, or fatty acid partial esters of glycerol, such as glycerol monostearate or glycerol There is distearate. Suitable emulsifiers include surfactants, such as nonionic surfactants, such as polyalcohols or fatty acid esters of ethylene oxide adducts thereof, such as polyglycerol fatty acid esters or polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters such as Sterol or polyoxyethylene fatty alcohol ethers or fatty acid esters such as sorbitan oleate and / or sorbitan isostearate, such as, for example, an alkali metal salt of an anionic surfactant, for example a fatty alcohol sulfonate, Such as sodium lauryl sulfate, sodium cetyl sulfate or sodium stearyl sulfate, which are generally used in the presence of the fatty alcohols described above, for example cetyl alcohol or stearyl alcohol. Among them, it is possible to add an agent for preventing the drying of the cream, for example, a polyalcohol such as glycerol, sorbitol, propylene glycol and / or polyethylene glycol to the aqueous phase or to add a preservative, perfume or the like to the aqueous phase.

The pharmaceutical preparations of the present invention may be paraffinic, especially low viscosity paraffin, which may be an anhydrous ointment and which is suitable for topical use and is liquid at body temperature, or which contains the natural or partially synthetic fat, for example coconut fatty acid triglycerides Sorbitan monostearate and distearate, silicones such as polymethylsiloxane, such as hexamethyldisiloxane, or octamethyl triisostearate, such as, for example, glycerol monostearate and distearate, Siloxanes, and may contain, for example, fatty alcohols associated with aqueous creams and increasing water absorption capacity, and sterols, wool waxes, other emulsifiers and / or other additives.

However, the present invention is not limited to the above-listed pharmaceutically acceptable carriers and the like, and these are merely illustrative.

The amount of the fecal and broiler complex extract to be contained in the pharmaceutical composition varies depending on the condition and body weight of the patient, the severity of the disease, the drug form, the administration route and the period, but may be appropriately selected depending on the case. For example, the combined extract of fowl and broiler chickens may be orally administered at a dose of 0.0001 to 1000 mg / kg per day, preferably 0.1 to 1000 mg / kg per day, and the application may be applied once or several times per day You may. In addition, the pharmaceutical composition may contain 0.0001 to 50% by weight of the fowl and broiler complex extract based on the total weight of the composition. The pharmaceutical compositions may be applied to mammals, such as humans, by a variety of routes, for example, transdermal, oral, intravenous, intramuscular, or subcutaneous injection.

In addition, the pharmaceutical composition of the present invention may contain at least one active ingredient which exhibits improvement, relief, treatment or prevention of allergic dermatitis in addition to a complex extract of fecal and broiler chickens.

In addition, the pharmaceutical composition of the present invention can be used alone, or in combination with methods using surgery, hormone therapy, drug therapy and biological response modifiers, for the amelioration, alleviation, treatment or prevention of allergic dermatitis.

The present invention also provides a health functional food for preventing or ameliorating allergic dermatitis, which comprises a combined extract of fusarium and broiler chickens.

The combined extract may be an extract obtained by mixing the fowl and broiler chickens at a weight ratio of 1: 0.1 to 1:10, preferably 1: 0.5 to 1: 5 by weight.

As a preferred example, it is preferable that the combined extract is extracted with 30 or 70% ethanol and the single extracts are mixed at a weight ratio of 1: 0.5 to 1: 5.

The health functional food may contain flavoring agents such as various nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, coloring agents and thickening agents (cheese, chocolate etc.), pectic acid and its salts, alginic acid and its salts, Organic acid, protective colloid thickener, pH adjusting agent, stabilizer, antiseptic, glycerin, alcohol, carbonating agent used in carbonated beverages, and the like, as well as pulp for producing natural fruit juice and fruit juice drinks and vegetable drinks ≪ / RTI > These components may be used independently or in combination.

The health functional food may be any one of meat, sausage, bread, chocolate, candy, snack, confectionery, pizza, ramen, gum, ice cream, soup, beverage, tea, functional water, drink, alcoholic beverage, .

The health functional food may further contain food additives and the suitability for "food additives" is not limited to those specified in the General Regulations of the Food Additives Ordinance approved by the Food and Drug Administration, And standards.

Examples of the products listed in the above-mentioned "food additives" include natural products such as ketones, chemical products such as glycine, potassium citrate, nicotinic acid and cinnamic acid, coloring matter, licorice extract, crystalline cellulosic, high- , A sodium L-glutamate preparation, a noodle-added alkaline agent, a preservative preparation, a tar coloring agent, and the like.

In the process for producing the health functional food of the present invention, the compound extracts of the feces and broiler chickens of the present invention, which are added to foods containing beverages, can be appropriately added or decreased as required, and preferably about 100% 1 to 15% by weight.

The present invention also provides a cosmetic composition for improving allergic dermatitis, which comprises a combined extract of flaxseed and broiler chicks.

The combined extract may be an extract obtained by mixing the fowl and broiler chickens at a weight ratio of 1: 0.1 to 1:10, preferably 1: 0.5 to 1: 5 by weight.

As a preferred example, it is preferable that the combined extract is extracted with 30 or 70% ethanol by mixing the fowl and broiler chickens at a weight ratio of 1: 0.5 to 1: 5.

In the present invention, the cosmetic composition of the present invention can be used in cosmetics such as soft longevity, astringent lotion, nutritional lotion, nutritional cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, pack, powder, body lotion, A body oil, a body essence, a makeup base, a foundation, a hair dye, a shampoo, a rinse, and a body cleansing agent.

The cosmetic composition of the present invention can be prepared in various forms according to a conventional cosmetic preparation method using the above-mentioned flax and broiler complex extract, and can be used as a stabilizer, a dissolving agent, a vitamin, a pigment, And customary adjuvants such as perfumes.

Also, when the cosmetic composition is prepared in the form of a perfume product, a shampoo, a hair lotion, a hair cream, a hair gel or the like containing the complex extract of the feces and broiler chicks, it can be diluted with a usual cleansing solution, have.

The cosmetic composition of the present invention is particularly preferably prepared in the form of a lotion, lotion, cream, or essence.

In the cosmetic composition of the present invention, the foliar and broiler complex extract may be added to the cosmetic composition in an amount of 0.1% by weight to 10% by weight with respect to the total liquid weight of the cosmetic composition, and 0.001 to 5 By weight, preferably 0.01 to 3% by weight, based on the total weight of the cosmetic composition.

The numerical values set forth herein should be construed to cover equivalent ranges unless otherwise indicated.

Best Mode for Carrying Out the Invention Hereinafter, preferred examples and formulation examples are shown to facilitate understanding of the present invention. However, the following examples and preparations are provided only for the purpose of easier understanding of the present invention, and the contents of the present invention are not limited by the examples or preparation examples.

Example 1 Immunosuppressive Effect of Combined Extracts of Zyseal and Broiler Chicks

1.1 Manufacture of complex extracts of root and broiler

Chicken was purchased from Jecheon Herbang Herb (Jecheon City, Chungbuk) and used in the medicines (Dongdaemun-gu, Seoul). 30% ethanol was added 10 times by weight to 62.5 g of fibrin and 37.5 g of broiler chickens, respectively, and extracted twice at 90 to 95 캜 for 3 hours. The extracts of the extracts from broiler chickens and broiler chickens were filtered with a filter paper, and the filtrate was concentrated under reduced pressure to 15 brix in a vacuum concentrator. The resulting concentrate was preliminarily frozen at -45 캜 for 20 minutes in a preliminary freezer, and then lyophilized with a freeze dryer to prepare a powder. The resulting extracts of broiler chickens and broiler chicks were mixed to prepare a complex extract powder.

Table 1 below shows the content of flax and broilers used for the preparation of the complex extract.

[Table 1]

1.2 Manufacture of single extracts of root and broiler

Since it is known that Zyseil and broiler chickens have an inflammation - improving effect, comparative experiments have confirmed whether the combined extracts of Zysei and broiler chicks are synergistic compared with single extracts. The single extracts of Zysei and broiler were prepared in the same manner as the compound extracts of 1.1 except that 100g of zygosan and 100g of broth were used respectively.

The content of flax and broiler chickens contained in the extracts of the persimmon single extract (Comparative Example 1) and the broiler mono extract (Comparative Example 2) are shown in Table 2 below.

[Table 2]

1.3 Confirmation of skin irritation inhibitory effect of compound extract

To investigate the inhibitory effect of compound extract on skin immune response, contact dermatitis model induced by 2,4-dinitrofluorobenzene (DNFB) was used as an animal model of atopic dermatitis. The application of DNFB, a T-cell mediated inflammatory reaction chemical, induces delayed contact dermatitis similar to atopy in mice. In the case of repeated exposure, skin irritation caused by infiltration of T- Of allergic dermatitis, atopic dermatitis is widely used for the study of allergic dermatitis . Female BALB / c mice were purchased from Samtaco BIO KOREA at 7 weeks of age.

Experimental animals were adapted for more than 1 week under conditions of temperature 22 ± 2 ℃, humidity 55 ± 10% and illumination time 12 hours (07: 00 ~ 19: 00) And allowed the animals to eat freely.

In order to confirm the immune response in the skin, the back of the experimental animal was epilated in the day before the experiment. On day 0 and day 1, 20 μl of 1% DNFB solution dissolved in acetone-olive oil (4: 1) was uniformly applied to rats to induce allergic dermatitis.

The combined extracts of Zysei and broiler, Zygocyma single extract and Broiler chrysanthemum extract were orally administered at 100 mg / kg in distilled water twice daily for 7 days from the 0th to 6th day of the experiment. The mice were orally administered at a dose of 10 ml / kg of primary distilled water. Control mice were treated with prednisolone (prednisolone) at a dose of 10 mg / kg as a positive control.

On the sixth day of experiment, 20 μl of a 0.5% DNFB solution dissolved in acetone-olive oil (4: 1) was further applied to the right ear of rats. Ear thickness was measured with an engineering caliper immediately prior to application and 24 hours after application and the size of edema was assessed as an increase in ear thickness.

The results are shown in FIG. 1 and Table 3.

[Table 3]

As can be seen from Figs. 1 and 3, the combined extracts of fowl and broiler chicks significantly inhibited ear edema in the DNFB-induced contact dermatitis model compared with the control group. More specifically, the ear thickness after applying a 0.5% DNFB solution 24 hours later the control group 0.16 ± 0.02mm to the ear thickness of the composite Extract 100mg / kg administered group, while an increase is increased 0.07 ± 0.01mm was 55.8% inhibited ear edema (p < 0.05 ). Compared with the control group, the group administered with 100 mg / kg of the single extract of Zysexil and the group administered with 100 mg / kg of the single extract of the broiler group of Comparative Example 2 showed 21.1% and 3.7% of the effect of suppressing ear edema, respectively. In other words, there was no significant difference between the single extracts of Zyseil and broiler chicks compared to the control group, and it showed a remarkably low edema suppression effect compared with the combined extracts of Zysei and broiler chicks. The results showed that the combined extracts of Zyseil and broiler chicks had remarkably improved edema inhibition effect compared to the single extract of Zysei and broiler chicks.

Compared with the positive control, prednisolone showed a similar degree of edema inhibition. Since the compound of prednisolone is a compound, considering the process for preparing and purifying it, it can be seen that the compound extract of the present invention has a usefulness in manufacturing process as compared with prednisolone and has an immune response inhibiting effect enough to replace it.

Preparation Example 1. Preparation of medicines

1.1 Manufacture of Powder

Combined extract of flaxseed and broiler 100mg

Lactose 100mg

10 mg

The above components are mixed and filled in airtight bags to prepare powders.

1.2 Preparation of tablets

Combined extract of flaxseed and broiler 100mg

Corn starch 100 mg

Lactose 100mg

Magnesium stearate 2 mg

After mixing the above components, tablets are prepared by tableting according to the usual preparation method of tablets.

1.3 Preparation of capsules

Combined extract of flaxseed and broiler 100mg

Corn starch 100 mg

Lactose 100mg

Magnesium stearate 2 mg

The above components are mixed according to a conventional capsule preparation method and filled into gelatin capsules to prepare tablets.

1.4 Manufacture of Injection

Combined extract of flaxseed and broiler 100mg

Sterile sterilized water for injection

pH adjuster

(2 ml) per 1 ampoule in accordance with the usual injection method.

1.5 Manufacture of liquids

Combined extract of flaxseed and broiler 100mg

Sugar 20g

20g per isomer

Lemon incense quantity

Purified water was added to make a total of 1,00 ml. The above components are mixed according to a usual method for producing a liquid agent, and then filled in a brown bottle and sterilized to prepare a liquid agent.

Formulation Example 2. Preparation of Health Functional Foods

Combined extract of flaxseed and broiler 100mg

Vitamin mixture quantity

70 [mu] g of vitamin A acetate

Vitamin E 1.0 mg

0.13 mg vitamin B1

0.15 mg of vitamin B2

0.5 mg vitamin B6

0.2 [mu] g vitamin B12

10 mg vitamin C

Biotin 10 μg

Nicotinic acid amide 1.7 mg

50 ㎍ of folic acid

Calcium pantothenate 0.5 mg

Mineral mixture quantity

1.75 mg of ferrous sulfate

0.82 mg of zinc oxide

Calcium monophosphate 15 mg

Secondary calcium phosphate 55 mg

Potassium citrate 90 mg

100 mg of calcium carbonate

24.8 mg of magnesium chloride

Although the composition ratio of the above-mentioned vitamin and mineral mixture is comparatively mixed with a component suitable for a health functional food as a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above components may be mixed And then used in the manufacture of a health functional food composition (for example, a nutritious candy, etc.) according to a conventional method.

Formulation Example 3. Preparation of Health Functional Drink

Combined extract of zyseal and broiler 100 mg

Citric acid 1000 mg

100 g of oligosaccharide

Plum concentrate 2 g

Taurine 1 g

Purified water was added to a total of 900 ml

The above components were mixed according to a conventional health functional beverage manufacturing method, and the mixture was heated at 85 DEG C for about 1 hour with stirring, and the resulting solution was filtered to obtain a sterilized 2-liter container, which was sealed and sterilized, It is used in the manufacture of the health functional beverage composition of the invention.

Although the composition ratio is a mixture of the components suitable for the preferred beverage as a preferred embodiment, the blending ratio may be arbitrarily varied according to the regional and national preferences such as the demand level, the demanding country, and the intended use.

Formulation Example 4. Preparation of cosmetic preparation

Combined extract of flaxseed and broiler 100mg

3.0 mg of glycerin

Hydrogenated lecithin 1.0 mg

Cetostearyl alcohol 2.0

Polysorbate 60 1.5

Antioxidant 0.3

Antiseptic

Purified water quantity

Claims (9)

A pharmaceutical composition for preventing or treating allergic dermatitis, which comprises as an active ingredient a complex extract of Poncirus trifoliata and Cinnamommum cassia .
The pharmaceutical composition for preventing or treating allergic dermatitis according to claim 1, wherein the complex extract is extracted with water or an alcohol as an extraction solvent.
delete The pharmaceutical composition for preventing or treating allergic dermatitis according to claim 1, wherein the combined extract inhibits edema.
The pharmaceutical composition for preventing or treating allergic dermatitis according to claim 1, wherein the allergic dermatitis is contact dermatitis or atopic dermatitis.
A health functional food for prevention or improvement of allergic dermatitis comprising an extract of Zysei and broiler as an active ingredient.
delete A cosmetic composition for the improvement of allergic dermatitis, which comprises a complex extract of Zysei and broiler as an active ingredient.
delete

Images