KR102613550B1 - A ginsenoside complex comprising insoluble substance curcumin - Google Patents
A ginsenoside complex comprising insoluble substance curcumin Download PDFInfo
- Publication number
- KR102613550B1 KR102613550B1 KR1020180056694A KR20180056694A KR102613550B1 KR 102613550 B1 KR102613550 B1 KR 102613550B1 KR 1020180056694 A KR1020180056694 A KR 1020180056694A KR 20180056694 A KR20180056694 A KR 20180056694A KR 102613550 B1 KR102613550 B1 KR 102613550B1
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- KR
- South Korea
- Prior art keywords
- poorly soluble
- extract
- ginseng root
- water solubility
- composition
- Prior art date
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Classifications
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
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- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
본 발명은 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물을 포함하는 난용성 물질의 수용성 증가용 조성물; 상기 조성물을 포함하는 수용성이 증가된 난용성 물질; 상기 난용성 물질을 포함하는 화장료 조성물, 식품 조성물, 약학 조성물, 및 의약외품 조성물; 및 상기 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물을 이용한 난용성 물질의 수용성 증가 방법 및 수용성이 증가된 난용성 물질의 제조방법에 관한 것이다.
본 발명에 따른 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물은 난용성 물질의 수용성을 향상시킬 수 있으므로, 난용성 물질의 경구 및 주사제형으로의 제조, 저장 안정성 증가 및 약물 전달능력/체내 흡수율 증가 등에 유용하게 활용될 수 있다. 또한, 상기 추출물은 천연 유래이므로 인체에 부작용 없이 안전하게 이용될 수 있다.The present invention provides a composition for increasing the water solubility of poorly soluble substances comprising white ginseng root extract, red ginseng root extract, and ginseng fruit extract; Poorly soluble substances with increased water solubility including the composition; Cosmetic compositions, food compositions, pharmaceutical compositions, and quasi-drug compositions containing the above-mentioned poorly soluble substances; and a method for increasing water solubility of poorly soluble substances using the white ginseng root extract, red ginseng root extract, and ginseng fruit extract, and a method for producing poorly soluble substances with increased water solubility.
Since the white ginseng root extract, red ginseng root extract, and ginseng fruit extract according to the present invention can improve the water solubility of poorly soluble substances, they are useful for manufacturing poorly soluble substances into oral and injectable formulations, increasing storage stability, and increasing drug delivery ability/absorption rate in the body. It can be utilized effectively. Additionally, since the extract is of natural origin, it can be safely used without side effects on the human body.
Description
본 발명은 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물에서 선택된 하나 이상의 추출물을 포함하는 난용성 물질의 수용성 증가용 조성물; 상기 조성물을 포함하는 수용성이 증가된 난용성 물질; 상기 난용성 물질을 포함하는 화장료 조성물, 식품 조성물, 약학 조성물, 의약외품 조성물, 및 사료 조성물; 및 상기 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물에서 선택된 하나 이상의 추출물을 이용한 난용성 물질의 수용성 증가 방법 및 수용성이 증가된 난용성 물질 함유 조성물의 제조방법에 관한 것이다.The present invention provides a composition for increasing the water solubility of poorly soluble substances comprising one or more extracts selected from white ginseng root extract, red ginseng root extract, and ginseng fruit extract; Poorly soluble substances with increased water solubility including the composition; Cosmetic compositions, food compositions, pharmaceutical compositions, quasi-drug compositions, and feed compositions containing the above-mentioned poorly soluble substances; and a method for increasing the water solubility of poorly soluble substances using one or more extracts selected from the white ginseng root extract, red ginseng root extract, and ginseng fruit extract, and a method for producing a composition containing a poorly soluble substance with increased water solubility.
난용성 약물의 가용화(수용화)는 약물의 생체 이용율, 안정성 및 분산성을 향상시키며, 약물을 체내에 투여하기 위한 경구 및 주사제형으로 제제화시킬 수 있다는 점에서 필수적인 기술이다. 난용성인 약물을 수용화하는는 방법으로는 (1) 수혼화성 유기용매와 물의 혼합 용매에 약물을 용해시키는 방법; (2) 약물의 구조를 변화시켜 물에 용해되는 산 또는 염기의 염 형태로 개량하는 방법; (3) 약물을 제3의 물질과 결합시켜 물에 용해되는 복합체를 형성하는 방법; (4) 계면활성제를 가하여 약물을 수용액 중에 미셀화 시키는 방법 등이 사용되고 있다(Leon Lachman, Lea & Febiger, Philadelphia, 1986).Solubilization (water solubilization) of poorly soluble drugs is an essential technology in that it improves the bioavailability, stability, and dispersibility of drugs, and allows drugs to be formulated into oral or injectable formulations for administration into the body. Methods for water-solubilizing poorly soluble drugs include (1) dissolving the drug in a mixed solvent of a water-miscible organic solvent and water; (2) A method of changing the structure of a drug to form a water-soluble acid or base salt; (3) a method of combining a drug with a third substance to form a complex that is soluble in water; (4) A method of micellarizing a drug in an aqueous solution by adding a surfactant is being used (Leon Lachman, Lea & Febiger, Philadelphia, 1986).
난용성 물질의 수용화 방법들 중에서 계면활성제를 사용하여 약물의 화학적인 구조를 변화시키지 않고 가용화하는 방법은 다양한 약물을 가용화할 수 있는 방법으로서 널리 사용되고 있다. 계면활성제로는 소르비탄 지방산 에스테르 유도체(Tween) 및 폴리옥시에틸렌 모노알킬에테르 유도체(BRIJ 및 MYRJ 계열) 등의 비이온성 계면활성제가 널리 사용된다. 그러나 이들 계면활성제는 과민반응 등의 부작용으로 사용이 매우 제한되며, 미셀의 안정성이 매우 낮아서 비교적 장시간 방치할 경우 약물이 석출되는 단점이 있다.Among methods for solubilizing poorly soluble substances, the method of solubilizing drugs using surfactants without changing the chemical structure of the drug is widely used as a method of solubilizing various drugs. As surfactants, nonionic surfactants such as sorbitan fatty acid ester derivatives (Tween) and polyoxyethylene monoalkyl ether derivatives (BRIJ and MYRJ series) are widely used. However, the use of these surfactants is very limited due to side effects such as hypersensitivity reactions, and the stability of micelles is very low, so they have the disadvantage of precipitating the drug if left for a relatively long time.
또한, 상기와 같은 종래의 방법은 계면활성제를 비롯하여 다양한 산 또는 염기 등의 합성 화합물을 사용하여, 인체 과민반응 등의 심각한 부작용을 초래할 수 있음이 보고되었으며, 장시간 보관하거나 방치하는 경우 낮은 안정성으로 인해 약물이 석출되는 단점이 있는 것으로 확인되었다. In addition, it has been reported that the above conventional methods use synthetic compounds such as surfactants and various acids or bases, which can cause serious side effects such as hypersensitivity reactions in the human body, and due to low stability when stored or left for a long time. It was confirmed that there is a disadvantage in that the drug precipitates.
이러한 문제점을 해결하기 위해, 천연 물질을 이용하여 난용성 물질을 가용화하는 연구가 활발히 수행되고 있으며, 일 예로서, 스테비올 배당체를 이용한 수용성이 증가된 커큐미노이드의 추출 방법(한국 공개특허공보 제10-2017-0118624호) 등을 들 수 있다. 그러나, 여전히 보다 안전하고도 효율적인 방법으로 난용성 물질을 가용화하는 방법에 대한 추가 연구가 요구되고 있다.To solve this problem, research is being actively conducted on solubilizing poorly soluble substances using natural substances. As an example, a method for extracting curcuminoids with increased water solubility using steviol glycosides (Korean Patent Publication No. 10-2017-0118624), etc. However, further research is still required on how to solubilize poorly soluble substances in a safer and more efficient manner.
이러한 배경하에, 본 발명자들은 천연 물질을 이용하여 난용성 물질의 수용성을 증가시키는 방법을 개발하고자 예의 노력 연구한 결과, 백삼근 추출물, 홍삼근 추출물, 인삼열매 추출물을 이용하여 난용성 물질의 수용성을 현저하게 증가시킬 수 있음을 확인하여, 본 발명을 완성하였다.Against this background, the present inventors studied diligently to develop a method of increasing the water solubility of poorly soluble substances using natural substances. As a result, the water solubility of poorly soluble substances was significantly increased by using white ginseng root extract, red ginseng root extract, and ginseng fruit extract. By confirming that it can be increased, the present invention was completed.
본 발명의 하나의 목적은 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물에서 선택된 하나 이상의 추출물을 포함하는, 난용성 물질의 수용성 증가용 조성물을 제공하는 것이다.One object of the present invention is to provide a composition for increasing the water solubility of poorly soluble substances, comprising one or more extracts selected from white ginseng root extract, red ginseng root extract, and ginseng fruit extract.
본 발명의 다른 하나의 목적은 상기 조성물을 포함하는, 수용성이 증가된 난용성 물질을 제공하는 것이다. Another object of the present invention is to provide a poorly soluble material with increased water solubility comprising the composition.
본 발명의 또 다른 하나의 목적은 상기 수용성이 증가된 난용성 물질을 포함하는, 화장료 조성물을 제공하는 것이다.Another object of the present invention is to provide a cosmetic composition containing the poorly soluble substance with increased water solubility.
본 발명의 또 다른 하나의 목적은 상기 수용성이 증가된 난용성 물질을 포함하는, 식품 조성물을 제공하는 것이다.Another object of the present invention is to provide a food composition containing the poorly soluble substance with increased water solubility.
본 발명의 또 다른 하나의 목적은 상기 수용성이 증가된 난용성 물질을 포함하는, 의약외품 조성물을 제공하는 것이다.Another object of the present invention is to provide a quasi-drug composition containing the poorly soluble substance with increased water solubility.
본 발명의 또 다른 하나의 목적은 상기 수용성이 증가된 난용성 물질을 포함하는, 사료 조성물을 제공하는 것이다.Another object of the present invention is to provide a feed composition containing the poorly soluble substance with increased water solubility.
본 발명의 또 다른 하나의 목적은 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물에서 선택된 하나 이상의 추출물을 혼합하는 단계를 포함하는, 난용성 물질의 수용성 증가 방법을 제공하는 것이다.Another object of the present invention is to provide a method of increasing the water solubility of a poorly soluble substance, comprising mixing one or more extracts selected from white ginseng root extract, red ginseng root extract, and ginseng fruit extract.
본 발명의 또 다른 하나의 목적은 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물에서 선택된 하나 이상의 추출물을 난용성 물질에 처리하는 단계를 포함하는, 수용성이 증가된 난용성 물질의 제조방법을 제공하는 것이다.Another object of the present invention is to provide a method for producing a poorly soluble material with increased water solubility, comprising the step of treating one or more extracts selected from white ginseng root extract, red ginseng root extract, and ginseng fruit extract to a poorly soluble material.
본 발명의 또 다른 하나의 목적은 백삼근 추출물, 홍삼근 추출물, 인삼열매 추출물에서 선택된 하나 이상의 추출물, 및 난용성 물질을 혼합 및 열수용해 하는 제1단계; 및 상기 제1단계에서 얻어진 혼합물에 마이크로웨이브(microwave)를 처리하는 제2단계를 포함하는, 수용성이 증가된 난용성 물질 함유 조성물의 제조방법을 제공하는 것이다.Another object of the present invention is a first step of mixing and hot water dissolving one or more extracts selected from white ginseng root extract, red ginseng root extract, and ginseng fruit extract, and poorly soluble substances; and a second step of treating the mixture obtained in the first step with a microwave.
이를 구체적으로 설명하면 다음과 같다. 한편, 본 발명에서 개시된 각각의 설명 및 실시형태는 각각의 다른 설명 및 실시 형태에도 적용될 수 있다. 즉, 본 발명에서 개시된 다양한 요소들의 모든 조합이 본 발명의 범주에 속한다. 또한, 하기 기술된 구체적인 서술에 의하여 본 발명의 범주가 제한된다고 볼 수 없다.This is explained in detail as follows. Meanwhile, each description and embodiment disclosed in the present invention may also be applied to each other description and embodiment. That is, all combinations of the various elements disclosed in the present invention fall within the scope of the present invention. Additionally, the scope of the present invention cannot be considered limited by the specific description described below.
상기 목적을 달성하기 위한 본 발명의 하나의 양태는 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물에서 선택된 하나 이상의 추출물을 포함하는, 난용성 물질의 수용성 증가용 조성물을 제공한다.One aspect of the present invention for achieving the above object provides a composition for increasing the water solubility of poorly soluble substances, comprising one or more extracts selected from white ginseng root extract, red ginseng root extract, and ginseng fruit extract.
본 발명은 난용성 물질의 수용성을 증가시키는 물질로서 백삼근, 홍삼근 또는 인삼열매 추출물을 제공한다.The present invention provides white ginseng root, red ginseng root or ginseng fruit extract as a substance that increases the water solubility of poorly soluble substances.
본 발명의 용어, "백삼근"은 백삼이라고도 불리며, 4년근 이상의 인삼을 표피를 제거하고 건조하여 수분함량이 14% 이하가 되도록 가공한 것을 의미한다.The term "white ginseng" in the present invention, also called white ginseng, refers to ginseng roots of 4 years or older that have been processed to have a moisture content of 14% or less by removing the epidermis and drying it.
본 발명의 용어, "홍삼근"은 홍삼이라고도 불리며, 껍질을 벗기지 않은 수삼을 증숙 및 건조하여 수분함량이 14% 이하가 되도록 가공한 것을 의미한다.The term "red ginseng root" in the present invention, also called red ginseng, refers to unpeeled fresh ginseng that is steamed and dried and processed to have a moisture content of 14% or less.
본 발명의 용어, "인삼열매"(ginseng berry)는 4년근 인삼의 열매를 의미한다. The term "ginseng berry" in the present invention refers to the fruit of 4-year-old ginseng.
상기의 백삼근, 홍삼근, 인삼열매는 사포닌이 풍부하여 장내 환경 개선, 비만 예방, 항암 효과, 면역력 향상, 피로 개선, 우울증 예방, 노화 방지 등의 효과를 나타낸다고 알려져 있다. 그러나, 이들의 난용성 물질에 대한 수용성 증가 효과는 공지된바 없었다.The above-mentioned white ginseng root, red ginseng root, and ginseng fruit are rich in saponin and are known to have effects such as improving the intestinal environment, preventing obesity, anti-cancer effect, improving immunity, improving fatigue, preventing depression, and anti-aging. However, the effect of increasing the water solubility of these poorly soluble substances was not known.
본 발명의 용어, "추출물"은 상기 백삼근, 홍삼근, 인삼열매 또는 이들의 혼합물을 추출 처리하여 얻어지는 추출액, 상기 추출액의 희석액이나 농축액, 상기 추출액을 건조하여 얻어지는 건조물, 상기 추출액의 조정제물이나 정제물, 또는 이들의 혼합물 등 추출액 자체 및 추출액을 이용하여 형성 가능한 모든 제형의 추출물을 포함한다. As used herein, the term "extract" refers to an extract obtained by extracting and processing the white ginseng root, red ginseng root, ginseng fruit or a mixture thereof, a diluted or concentrated liquid of the extract, a dried product obtained by drying the extract, and a crude product or purified product of the extract. This includes extracts of all formulations that can be formed using the extract itself and the extract, or mixtures thereof.
또한, 상기 추출물은, 상기 각각의 해당 식물의 천연, 잡종 또는 변종 식물로부터 추출될 수 있고, 식물 조직 배양물로부터도 추출이 가능하다.Additionally, the extract may be extracted from natural, hybrid, or mutant plants of each of the plants, and may also be extracted from plant tissue culture.
또한, 상기 백삼근, 홍삼근, 인삼열매 또는 이들의 혼합물을 추출하는 방법은 특별히 제한되지 않으며, 당해 기술 분야에서 통상적으로 사용하는 방법에 따라 추출할 수 있다. 상기 추출 방법의 비제한적인 예로는, 열수 추출, 주정 추출, 착즙 추출, 초음파 추출, 환류 추출, 초임계 추출 등을 들 수 있으며, 이들은 단독으로 수행되거나 2종 이상의 방법을 병용하여 수행될 수 있다. Additionally, the method of extracting the white ginseng root, red ginseng root, ginseng fruit, or a mixture thereof is not particularly limited, and may be extracted according to a method commonly used in the art. Non-limiting examples of the extraction method include hot water extraction, alcohol extraction, juice extraction, ultrasonic extraction, reflux extraction, and supercritical extraction, which may be performed alone or by combining two or more methods. .
또한, 본 발명에서 사용되는 추출 용매의 종류는 특별히 제한되지 않으며, 당해 기술 분야에서 공지된 임의의 용매를 사용할 수 있다. 상기 추출 용매의 비제한적인 예로는 물, 탄소수 1 내지 4의 알코올 또는 이들의 혼합 용매 등을 들 수 있으며, 이들은 단독으로 사용되거나 1종 이상 혼합하여 사용될 수 있다. Additionally, the type of extraction solvent used in the present invention is not particularly limited, and any solvent known in the art can be used. Non-limiting examples of the extraction solvent include water, alcohols having 1 to 4 carbon atoms, or mixed solvents thereof, and these may be used alone or in combination of one or more types.
구체적으로, 본 발명의 추출물은 주정(에탄올) 추출 또는 착즙 추출된 것일 수 있고, 추출되어 농축된 것일 수 있다. 더욱 구체적으로, 상기 백삼근 추출물 및 홍삼근 추출물은 주정 추출되어 농축된 것일 수 있고, 상기 인삼열매 추출물은 주정 추출 또는 착즙 추출되어 농축된 것일 수 있으나, 이에 제한되지 않는다. 본 발명에서 "착즙"이란 과일이나 채소로 부터 즙액을 짜내는 것을 의미한다.Specifically, the extract of the present invention may be extracted with alcohol (ethanol) or juice, or may be extracted and concentrated. More specifically, the white ginseng root extract and the red ginseng root extract may be concentrated by extraction with alcohol, and the ginseng fruit extract may be concentrated by extraction with alcohol or juice, but are not limited thereto. In the present invention, “juicing” means squeezing juice from fruits or vegetables.
상기 백삼근 추출물, 홍삼근 추출물 또는 인삼열매 추출물은 총 조성물에 대하여 1 내지 25%(w/v)로 포함될 수 있으나, 이에 제한되지 않는다.The white ginseng root extract, red ginseng root extract, or ginseng fruit extract may be included in an amount of 1 to 25% (w/v) based on the total composition, but is not limited thereto.
본 발명의 목적상, 상기 백삼근 추출물, 홍삼근 추출물 또는 인삼열매 추출물은 난용성 물질의 수용성을 증가시키는 것일 수 있다.For the purpose of the present invention, the white ginseng root extract, red ginseng root extract, or ginseng fruit extract may increase the water solubility of poorly soluble substances.
본 발명의 용어, "난용성 물질"은 물 등의 용매에 잘 녹지 않는 성질을 갖는 물질을 의미하며, 본 발명의 목적상, 수용성이 낮은 물질을 의미할 수 있다. 물질의 난용성은 생체 이용율, 안정성 및 분산성 등을 감소시킴에 따라 활용도를 상당히 저하시키는바, 난용성 물질을 가용화하는 방법에 대한 요구가 지속되고 있다. 상기 난용성 물질은 물에 대한 용해도가 0.001 mg/mL 내지 50 mg/mL인 물질을 의미할 수 있으나 이에 제한되는 것은 아니다.As used herein, the term “poorly soluble material” refers to a material that does not dissolve well in solvents such as water, and for the purpose of the present invention, it may refer to a material with low water solubility. Poor solubility of materials significantly reduces their usability by reducing bioavailability, stability, and dispersibility, and there is a continuing need for methods to solubilize poorly soluble materials. The poorly soluble material may refer to a material having a solubility in water of 0.001 mg/mL to 50 mg/mL, but is not limited thereto.
구체적으로, 상기 난용성 물질은 커큐미노이드계 화합물일 수 있다.Specifically, the poorly soluble substance may be a curcuminoid-based compound.
상기 용어, "커큐미노이드계 화합물"(curcuminoid)은 커큐민 또는 커큐민 유도체를 갖는 선형의 다이어리헵타노이드(diarylheptanoid) 화합물을 의미한다. 천연 페놀이며, 뚜렷한 황색을 나타내고, 주로 강황에서 발견되고 있다. 커큐미노이드는 우수한 항산화 활성을 나타내므로 당뇨, 폐암, 유방암, 백혈병, 아토피, 비염, 간질환, 숙취, 변비, 알츠하이머, 뇌손상, 혈관성 치매 등 다양한 질환, 병증의 예방 또는 치료에 사용될 수 있다고 알려져 있으나, 물에 잘 녹지 않아 이용에 많은 제약이 있었다. 따라서, 이의 수용성을 증가시키기 위한 연구가 활발히 수행되고 있다.The term “curcuminoid” refers to a linear diaryheptanoid compound containing curcumin or a curcumin derivative. It is a natural phenol, has a distinct yellow color, and is mainly found in turmeric. Because curcuminoids exhibit excellent antioxidant activity, it is known that they can be used to prevent or treat various diseases and conditions such as diabetes, lung cancer, breast cancer, leukemia, atopy, rhinitis, liver disease, hangover, constipation, Alzheimer's, brain damage, and vascular dementia. However, there were many restrictions on its use because it did not dissolve well in water. Therefore, research is being actively conducted to increase its acceptability.
구체적으로, 상기 커큐미노이드계 화합물은 커큐민(crcumin), 디메톡시커큐민(demethoxycurcumin), 비스데메톡시커큐민(bisdemethoxycurcumin) 또는 이들의 조합일 수 있으며, 보다 구체적으로 커큐민일 수 있으나, 본 발명의 추출물에 의해 수용성이 증가될 수 있는 한, 이에 제한되지 않는다.Specifically, the curcuminoid-based compound may be curcumin, demethoxycurcumin, bisdemethoxycurcumin, or a combination thereof, and more specifically may be curcumin, but may be used in the extract of the present invention. It is not limited thereto, as long as water solubility can be increased.
본 발명의 구체적인 일 실시예에서는, 백삼근 추출 농축액, 홍삼근 추출 농축액, 인삼열매 추출 농축액, 인삼열매 착즙 추출 농축액을 제조하였고, 이의 혼합물을 난용성 물질인 커큐민에 처리한 결과 커큐민의 수용성이 현저히 증가하는 것을 확인하였다(표 1, 및 도 1 내지 4).In a specific embodiment of the present invention, white ginseng root extract concentrate, red ginseng root extract concentrate, ginseng fruit extract concentrate, and ginseng fruit juice extract concentrate were prepared, and the mixture was treated with curcumin, a poorly soluble substance. As a result, the water solubility of curcumin significantly increased. This was confirmed (Table 1 and Figures 1 to 4).
이는, 상기 추출물은 난용성 물질의 수용성을 증가시킬 수 있으며, 나아가 난용성 물질의 활용도를 넓히는데 유용하게 사용될 수 있음을 시사하는 것이다.This suggests that the extract can increase the water solubility of poorly soluble substances and, furthermore, can be usefully used to expand the utility of poorly soluble substances.
다른 하나의 양태는 상기 조성물을 포함하는, 수용성이 증가된 난용성 물질을 제공한다. Another aspect provides a poorly soluble material with increased water solubility comprising the composition.
상기 "난용성 물질"에 대한 설명은 전술한 바와 같다.The description of the “poorly soluble substance” is the same as described above.
본 발명의 조성물은 난용성 물질의 수용성을 증가시킬 수 있는 백삼근 추출물, 홍삼근 추출물, 인삼열매 추출물에서 선택된 하나 이상의 추출물을 포함하므로, 이를 포함하는 난용성 물질은 수용성이 증가될 수 있다.Since the composition of the present invention contains one or more extracts selected from white ginseng root extract, red ginseng root extract, and ginseng fruit extract, which can increase the water solubility of poorly soluble substances, the water solubility of poorly soluble substances containing this can be increased.
또 다른 하나의 양태는 상기 수용성이 증가된 난용성 물질을 포함하는, 약학 조성물을 제공한다. Another aspect provides a pharmaceutical composition comprising the poorly soluble substance with increased water solubility.
상기 "난용성 물질"에 대한 설명은 전술한 바와 같다.The description of the “poorly soluble substance” is the same as described above.
본 발명에서, 상기 약학 조성물은 수용성이 증가된 난용성 물질, 구체적으로 수용성이 증가된 커큐미노이드계 화합물을 포함하므로, 우수한 항산화 활성을 나타낼 수 있다. 따라서, 상기 약학 조성물은 항산화 활성을 통해 다양한 질환을 예방 또는 치료할 수 있다. In the present invention, the pharmaceutical composition contains a poorly soluble substance with increased water solubility, specifically a curcuminoid-based compound with increased water solubility, and thus can exhibit excellent antioxidant activity. Therefore, the pharmaceutical composition can prevent or treat various diseases through antioxidant activity.
구체적으로, 상기 질환은 당뇨, 폐암, 유방암, 백혈병, 아토피, 비염, 간질환, 숙취, 변비, 알츠하이머, 뇌손상, 혈관성 치매 또는 이들의 조합일 수 있으나, 이에 제한되지 않는다.Specifically, the disease may be diabetes, lung cancer, breast cancer, leukemia, atopy, rhinitis, liver disease, hangover, constipation, Alzheimer's, brain damage, vascular dementia, or a combination thereof, but is not limited thereto.
상기 용어, "예방"은 상기 수용성이 증가된 난용성 물질을 포함하는 조성물의 투여로 질환의 증세를 억제 또는 지연시키는 모든 행위를 의미한다. The term “prevention” refers to any action that suppresses or delays the symptoms of a disease by administering a composition containing the poorly soluble substance with increased water solubility.
상기 용어, "치료"는 상기 수용성이 증가된 난용성 물질을 포함하는 조성물의 투여로 질환의 증세가 호전되거나 이롭게 변경되는 모든 행위를 의미한다.The term “treatment” refers to any action in which the symptoms of a disease are improved or beneficially changed by administration of a composition containing a poorly soluble substance with increased water solubility.
본 발명의 약학적 조성물은 조성물 총 중량에 대하여 상기 난용성 물질을 0.001 내지 80, 구체적으로 0.001 내지 70, 더욱 구체적으로 0.001 내지 60 중량%로 포함할 수 있으나, 이에 제한되지 않는다.The pharmaceutical composition of the present invention may contain 0.001 to 80, specifically 0.001 to 70, and more specifically 0.001 to 60% by weight of the poorly soluble substance based on the total weight of the composition, but is not limited thereto.
또한, 상기 약학적 조성물은 약학적 조성물의 제조에 통상적으로 사용하는 약학적으로 허용가능한 담체, 부형제 또는 희석제를 추가로 포함할 수 있고, 상기 담체는 비자연적 담체(non-naturally occuring carrier)를 포함할 수 있다. 상기 담체, 부형제 및 희석제의 구체적인 예로는 락토즈, 덱스트로즈, 수크로스, 솔비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 전분, 아카시아 고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로즈, 메틸 셀룰로즈, 미정질 셀룰로스, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 탈크, 마그네슘 스테아레이트 또는 광물유 등이 사용될 수 있으나, 이에 제한되지 않는다.In addition, the pharmaceutical composition may further include a pharmaceutically acceptable carrier, excipient, or diluent commonly used in the preparation of pharmaceutical compositions, and the carrier includes a non-naturally occurring carrier. can do. Specific examples of the carriers, excipients and diluents include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, gum acacia, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, Microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, or mineral oil may be used, but are not limited thereto.
또한, 상기 약학적 조성물은 각각 통상의 방법에 따라 정제, 환제, 산제, 과립제, 캡슐제, 현탁제, 내용액제, 유제, 시럽제, 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결 건조제 및 좌제으로 이루어진 군으로부터 선택되는 어느 하나의 제형을 가질 수 있으며, 경구 또는 비경구의 여러 가지 제형일 수 있다. 제제화할 경우에는 보통 사용하는 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제된다. 경구투여를 위한 고형제제에는 정제, 환제, 산제, 과립제, 캡슐제 등이 사용될 수 있으며, 상기 고형제제는 적어도 하나 이상의 부형제 예를 들면, 전분, 탄산칼슘, 수크로오스(sucrose) 또는 락토오스(lactose), 젤라틴 등이 사용될 수 있다. 또한, 단순한 부형제 이외에 스테아린산 마그네슘, 탈크 등과 같은 윤활제 등이 사용될 수 있다. 경구투여를 위한 액상제제로는 현탁제, 내용액제, 유제, 시럽제 등이 사용될 수 있으며, 흔히 사용되는 단순희석제인 물, 리퀴드 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제, 보존제 등이 사용될 수 있다. 비경구투여를 위한 제제에는 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결건조 제제 또는 좌제 등이 사용될 수 있다. 비수성용제, 현탁용제로는 프로필렌글리콜(propylene glycol), 폴리에틸렌 글리콜, 올리브 오일과 같은 식물성 기름, 에틸올레이트와 같은 주사 가능한 에스테로 등이 사용될 수 있다. 좌제의 기제로는 위텝솔(witepsol), 마크로골, 트윈(tween) 61, 카카오지, 라우린지, 글리세로젤라틴 등이 사용될 수 있으나, 이에 제한되지 않는다.In addition, the pharmaceutical compositions can be manufactured into tablets, pills, powders, granules, capsules, suspensions, solutions for internal use, emulsions, syrups, sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations and suppositories according to conventional methods. It may have any one dosage form selected from the group consisting of, and may be various oral or parenteral dosage forms. When formulated, it is prepared using diluents or excipients such as commonly used fillers, extenders, binders, wetting agents, disintegrants, and surfactants. Solid preparations for oral administration may include tablets, pills, powders, granules, capsules, etc., and the solid preparations may contain at least one excipient such as starch, calcium carbonate, sucrose or lactose, Gelatin, etc. may be used. Additionally, in addition to simple excipients, lubricants such as magnesium stearate, talc, etc. may be used. Liquid preparations for oral administration include suspensions, oral solutions, emulsions, and syrups. In addition to the commonly used simple diluents such as water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives can be used. can be used Preparations for parenteral administration may include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, or suppositories. Non-aqueous solvents and suspensions may include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, and injectable esters such as ethyl oleate. As a base for suppositories, witepsol, macrogol, tween 61, cacao, laurel, glycerogelatin, etc. may be used, but are not limited thereto.
본 발명의 약학적 조성물은 약학적으로 유효한 양으로 투여할 수 있다.The pharmaceutical composition of the present invention can be administered in a pharmaceutically effective amount.
상기 용어, "투여"는 적절한 방법으로 개체에게 상기 난용성 물질을 포함하는 조성물을 도입하는 것을 의미한다.The term “administration” means introducing a composition containing the poorly soluble substance into an individual by an appropriate method.
상기 용어, "개체"는 질환이 발병하였거나 발병할 수 있는 인간을 포함한 쥐, 생쥐, 가축 등의 모든 동물을 의미한다. 구체적인 예로, 인간을 포함한 포유동물일 수 있다.The term “individual” refers to all animals, such as rats, mice, and livestock, including humans, that have or may develop the disease. As a specific example, it may be a mammal, including humans.
상기 용어, "약학적으로 유효한 양"은 의학적 치료에 적용 가능한 합리적인 수혜/위험 비율로 질환을 치료하기에 충분한 양을 의미하며, 유효 용량 수준은 개체 종류 및 중증도, 연령, 성별, 약물의 활성, 약물에 대한 민감도, 투여 시간, 투여 경로 및 배출 비율, 치료 기간, 동시 사용되는 약물을 포함한 요소 및 기타 의학 분야에 잘 알려진 요소에 따라 결정될 수 있다. The term "pharmaceutically effective amount" means an amount sufficient to treat the disease with a reasonable benefit/risk ratio applicable to medical treatment, and the effective dose level is determined by the type and severity of the subject, age, sex, activity of the drug, It can be determined based on factors including sensitivity to the drug, time of administration, route of administration and excretion rate, duration of treatment, concurrently used drugs, and other factors well known in the field of medicine.
상기 약학적 조성물은 개별 치료제로 투여하거나 다른 치료제와 병용하여 투여할 수 있고 종래의 치료제와는 순차적 또는 동시에 투여할 수 있다. 또한, 단일 또는 다중 투여할 수 있다. 상기 요소를 모두 고려하여 부작용 없이 최소한의 양으로 최대 효과를 얻을 수 있는 양을 투여하는 것이 중요하며, 이는 당업자에 의해 용이하게 결정될 수 있다.The pharmaceutical composition can be administered as an individual treatment or in combination with other treatments, and can be administered sequentially or simultaneously with conventional treatments. Additionally, it can be administered single or multiple times. Considering all of the above factors, it is important to administer an amount that can achieve maximum effect with the minimum amount without side effects, and this can be easily determined by a person skilled in the art.
또한, 상기 약학적 조성물은 목적하는 방법에 따라 경구 투여하거나 비경구 투여(예를 들어, 정맥 내, 피하, 복강 내 또는 국소에 적용)할 수 있으며, 투여량은 환자의 상태 및 체중, 질병의 정도, 약물형태, 투여경로 및 시간에 따라 다르지만, 당업자에 의해 적절하게 선택될 수 있다. 구체적인 예로, 상기 약학적 조성물은 일반적으로 0.001 내지 1000 mg/kg, 더욱 구체적으로 0.05 내지 200 mg/kg, 가장 구체적으로 0.1 내지 100 mg/kg의 양을 1일 1회 내지 수회로 나누어 투여할 수 있으나, 바람직한 투여량은 개체의 상태 및 체중, 질병의 정도, 약물형태, 투여경로 및 기간에 따라 당업자에 의해 적절하게 선택될 수 있다.In addition, the pharmaceutical composition can be administered orally or parenterally (e.g., intravenously, subcutaneously, intraperitoneally, or topically) depending on the desired method, and the dosage is determined by the patient's condition and weight, and the severity of the disease. It varies depending on the degree, drug form, administration route and time, but can be appropriately selected by a person skilled in the art. As a specific example, the pharmaceutical composition can be administered in an amount of generally 0.001 to 1000 mg/kg, more specifically 0.05 to 200 mg/kg, and most specifically 0.1 to 100 mg/kg once or several times a day. However, the preferred dosage can be appropriately selected by a person skilled in the art depending on the individual's condition and weight, degree of disease, drug form, administration route and period.
또 다른 하나의 양태는 상기 수용성이 증가된 난용성 물질을 포함하는, 식품 조성물을 제공한다. Another aspect provides a food composition comprising the poorly soluble substance with increased water solubility.
상기 "난용성 물질"에 대한 설명은 전술한 바와 같다.The description of the “poorly soluble substance” is the same as described above.
본 발명의 식품 조성물은 일상적으로 섭취하는 것이 가능하며, 일반 약품과는 달리 천연물을 원료로 하여 약품의 장기 복용 시 발생할 수 있는 부작용 등이 없는 장점이 있으므로, 수용성이 증가된 난용성 물질, 구체적으로 수용성이 증가된 커큐미노이드계 화합물에 의한 항산화 활성을 높은 수준으로 나타낼 수 있다.The food composition of the present invention can be consumed on a daily basis, and unlike general drugs, it is made from natural products and has the advantage of having no side effects that may occur when taking the drug for a long period of time. Therefore, it contains poorly soluble substances with increased water solubility, specifically Antioxidant activity by curcuminoid compounds with increased water solubility can be shown at a high level.
본 발명의 용어, "식품"은 육류, 소시지, 빵, 초콜릿, 캔디류, 스낵류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알코올음료, 비타민 복합제, 건강기능식품 및 건강식품 등이 있으며, 통상적인 의미에서의 식품을 모두 포함한다.As used herein, “food” refers to meat, sausages, bread, chocolate, candies, snacks, confectionery, pizza, ramen, other noodles, gum, dairy products including ice cream, various soups, beverages, tea, drinks, and alcoholic beverages. , vitamin complexes, health functional foods, and health foods, etc., and include all foods in the conventional sense.
상기 건강기능(성)식품(health functionalfood)은 특정보건용 식품(food for special health use, FoSHU)과 동일한 용어로, 영양 공급 외에도 생체조절기능이 효율적으로 나타나도록 가공된 의학, 의료효과가 높은 식품을 의미한다. 여기서 '기능(성)'은 인체의 구조 및 기능에 대하여 영양소를 조절하거나 생리학적 작용 등과 같은 보건용도에 유용한 효과를 얻는 것을 의미한다. 상기 건강식품(health food)은 일반식품에 비해 적극적인 건강유지나 증진 효과를 가지는 식품을 의미하고, 건강보조식품(health supplementfood)은 건강보조 목적의 식품을 의미한다. 경우에 따라, 건강기능식품, 건강식품, 건강보조식품의 용어는 호용될 수 있다.The above-mentioned health functional food (health functional food) is the same term as food for special health use (FoSHU), and is a medical food with high medical effects that is processed to efficiently exhibit bioregulatory functions in addition to supplying nutrients. means. Here, 'function' means controlling nutrients for the structure and function of the human body or obtaining useful effects for health purposes, such as physiological effects. The above-mentioned health food refers to food that has a more active health maintenance or promotion effect compared to general food, and health supplement food refers to food for the purpose of health supplementation. In some cases, the terms health functional food, health food, and health supplement may be used interchangeably.
구체적으로, 상기 건강기능식품은 본 발명의 수용성이 증가된 난용성 물질을 음료, 차류, 향신료, 껌, 과자류 등의 식품 소재에 첨가하거나, 캡슐화, 분말화, 현탁액 등으로 제조한 식품으로, 이를 섭취할 경우 건강상 특정한 효과를 가져오는 것을 의미하나, 일반 약품과는 달리 식품을 원료로 하여 약품의 장기 복용 시 발생할 수 있는 부작용이 없는 장점이 있다.Specifically, the health functional food is a food manufactured by adding the poorly soluble substance with increased water solubility of the present invention to food materials such as beverages, teas, spices, gum, and confectionery, or by encapsulating, powdering, or suspending it. It means that it brings about specific health effects when ingested, but unlike regular drugs, it has the advantage of not having any side effects that may occur when taking the drug for a long time since it is made from food.
본 발명의 식품은 당업계에서 통상적으로 사용되는 방법에 의하여 제조 가능하며, 당업계에서 통상적으로 첨가하는 원료 및 성분을 첨가하여 제조할 수 있다. 또한, 상기 식품 조성물은 식품으로 인정되는 제형이면 다양한 형태의 제형으로 제한 없이 제조될 수 있다.The food of the present invention can be manufactured by methods commonly used in the art, and can be manufactured by adding raw materials and ingredients commonly added in the art. In addition, the food composition can be manufactured without limitation in various forms as long as it is a formulation recognized as a food.
또한, 상기 식품 조성물은 생리학적으로 허용 가능한 담체를 추가로 포함할 수 있는데, 담체의 종류는 특별히 제한되지 않으며 당해 기술 분야에서 통상적으로 사용되는 담체라면 어느 것이든 사용할 수 있다.In addition, the food composition may further include a physiologically acceptable carrier. The type of carrier is not particularly limited, and any carrier commonly used in the art can be used.
또한, 상기 식품 조성물은 식품 조성물에 통상 사용되어 냄새, 맛, 시각 등을 향상시킬 수 있는 추가 성분을 포함할 수 있다. 예들 들어, 비타민 A, C, D, E, B1, B2, B6, B12, 니아신(niacin), 비오틴(biotin), 폴레이트(folate), 판토텐산(panthotenic acid) 등을 포함할 수 있다. 또한, 아연(Zn), 철(Fe), 칼슘(Ca), 크롬(Cr), 마그네슘(Mg), 망간(Mn), 구리(Cu), 크륨(Cr) 등의 미네랄; 및 라이신, 트립토판, 시스테인, 발린 등의 아미노산을 포함할 수 있다.Additionally, the food composition may contain additional ingredients that are commonly used in food compositions to improve smell, taste, vision, etc. For example, it may include vitamins A, C, D, E, B1, B2, B6, B12, niacin, biotin, folate, pantothenic acid, etc. Additionally, minerals such as zinc (Zn), iron (Fe), calcium (Ca), chromium (Cr), magnesium (Mg), manganese (Mn), copper (Cu), and chromium (Cr); and amino acids such as lysine, tryptophan, cysteine, and valine.
또한, 상기 식품 조성물은 방부제(소르빈산 칼륨, 벤조산나트륨, 살리실산, 데히드로초산나트륨 등), 살균제(표백분과 고도 표백분, 차아염소산나트륨 등), 산화방지제(부틸히드록시아니졸(BHA), 부틸히드록시톨류엔(BHT) 등), 착색제(타르색소 등), 발색제(아질산 나트륨, 아초산 나트륨 등), 표백제(아황산나트륨), 조미료(MSG 글루타민산나트륨 등), 감미료(둘신, 사이클레메이트, 사카린, 나트륨 등), 향료(바닐린, 락톤류 등), 팽창제(명반, D-주석산수소칼륨 등), 강화제, 유화제, 증점제(호료), 피막제, 검기초제, 거품억제제, 용제, 개량제 등의 식품 첨가물(food additives)을 포함할 수 있다. 상기 첨가물은 식품의 종류에 따라 선별하고 적절한 양으로 사용할 수 있다.In addition, the food composition contains preservatives (potassium sorbate, sodium benzoate, salicylic acid, sodium dehydroacetate, etc.), disinfectants (bleaching powder, high bleaching powder, sodium hypochlorite, etc.), antioxidants (butylhydroxyanisole (BHA), butylhydroxide) roxitoluene (BHT), etc.), colorants (tar color, etc.), coloring agents (sodium nitrite, sodium nitrite, etc.), bleaching agents (sodium sulfite), seasonings (MSG monosodium glutamate, etc.), sweeteners (dulcine, cyclemate, saccharin) , sodium, etc.), flavorings (vanillin, lactones, etc.), leavening agents (alum, D-potassium hydrogen tartrate, etc.), strengtheners, emulsifiers, thickeners (grease), coating agents, gum base agents, anti-foam agents, solvents, improvers, etc. May contain food additives. The additives can be selected according to the type of food and used in an appropriate amount.
또 다른 하나의 양태는 상기 수용성이 증가된 난용성 물질을 포함하는, 화장료 조성물을 제공한다. Another aspect provides a cosmetic composition comprising the poorly soluble material with increased water solubility.
상기 "난용성 물질"에 대한 설명은 전술한 바와 같다.The description of the “poorly soluble substance” is the same as described above.
본 발명에서, 상기 화장료 조성물은 수용성이 증가된 난용성 물질, 구체적으로 수용성이 증가된 커큐미노이드계 화합물을 포함하므로, 우수한 항산화 활성을 나타낼 수 있다. 따라서, 상기 화장료 조성물은 항산화 활성을 통해 피부 미백, 피부 주름 개선, 피부 트러블 개선, 피부 노화 방지 등의 다양한 효과를 나타낼 수 있다. In the present invention, the cosmetic composition contains poorly soluble substances with increased water solubility, specifically curcuminoid compounds with increased water solubility, and thus can exhibit excellent antioxidant activity. Therefore, the cosmetic composition can exhibit various effects such as skin whitening, skin wrinkle improvement, skin trouble improvement, and skin aging prevention through antioxidant activity.
본 발명의 화장료 조성물은 상기 수용성이 증가된 난용성 물질을 총 중량 대비 0.0001 내지 80 중량%, 구체적으로 0.0005 내지 70 중량%, 더욱 구체적으로 0.001 내지 60 중량% 포함할 수 있다. 상기 함량이 0.0001 중량% 미만이면 본래 목적하는 효과를 충분하게 달성할 수 없어 바람직하지 못하며, 80 중량%를 초과하면 증가하는 함량만큼 뚜렷한 효과의 증대가 기대되지 않아 비경제적이며, 화장료 조성물의 안전성에 문제를 발생시킬 수 있다.The cosmetic composition of the present invention may contain 0.0001 to 80% by weight, specifically 0.0005 to 70% by weight, and more specifically 0.001 to 60% by weight of the poorly soluble material with increased water solubility based on the total weight. If the content is less than 0.0001% by weight, it is undesirable because the intended effect cannot be sufficiently achieved. If it exceeds 80% by weight, a significant increase in effect is not expected as the content increases, making it uneconomical and affecting the safety of the cosmetic composition. It may cause problems.
또한, 본 발명의 화장료 조성물은 피부에 사용하는 것으로서, 유연화장수(영양유액), 수렴화장수, 영양화장수, 영양크림, 마사지크림, 에센스, 팩, 피부접착용 패취, 피부접착용 겔, 파우더, 연고, 서스펜션, 에멀젼, 스프레이 또는 미용액 등의 통상의 화장료 형태로 제조될 수 있으나, 이에 제한되는 것은 아니다. 또한, 상기 화장료 조성물은 화장품, 비누, 세제 및 섬유 등의 피부에 접촉하는 피부접촉물질로 제조할 수도 있다. In addition, the cosmetic composition of the present invention is used on the skin, and includes softening lotion (nutritional emulsion), astringent lotion, nourishing lotion, nutritious cream, massage cream, essence, pack, skin adhesive patch, skin adhesive gel, powder, and ointment. , can be manufactured in the form of a conventional cosmetic such as suspension, emulsion, spray, or serum, but is not limited thereto. Additionally, the cosmetic composition may be manufactured from skin-contact substances such as cosmetics, soap, detergents, and textiles.
또한, 상기 화장료 조성물은 필요에 따라 일반 피부화장료에 배합되는 보통의 성분, 예를 들면, 유분, 물, 계면활성제, 보습제, 저급알콜, 증점제, 킬레이트제, 색소, 방부제, 향료 등의 화장품학적으로 허용 가능한 담체를 추가로 포함할 수 있으나, 이에 제한되는 것은 아니다. In addition, the cosmetic composition contains cosmetic ingredients such as common ingredients mixed in general skin cosmetics, such as oil, water, surfactants, moisturizers, lower alcohols, thickeners, chelating agents, pigments, preservatives, and fragrances, as needed. An acceptable carrier may be additionally included, but is not limited thereto.
본 발명의 화장료 조성물에 포함되는 화장품학적으로 허용 가능한 담체는 화장료 조성물의 제형에 따라 다양하다.Cosmetically acceptable carriers included in the cosmetic composition of the present invention vary depending on the formulation of the cosmetic composition.
구체적으로, 본 발명의 제형이 연고, 페이스트, 크림 또는 젤인 경우에는, 담체 성분으로서 동물성 유, 식물성 유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크, 산화 아연 등이 이용될 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2종 이상 혼합되어 사용될 수 있다.Specifically, when the formulation of the present invention is an ointment, paste, cream or gel, the carrier ingredients include animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, Zinc oxide and the like may be used, but are not limited thereto. These may be used alone or in combination of two or more types.
또한, 본 발명의 제형이 파우더 또는 스프레이인 경우에는, 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록사이드, 칼슘 실케이트, 폴리아미드 파우더 등이 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로하드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진제를 포함할 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2종 이상 혼합되어 사용될 수 있다.In addition, when the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silcate, polyamide powder, etc. can be used as carrier ingredients, and especially in the case of a spray, chlorofluorocarbons may be used as carrier ingredients. It may include, but is not limited to, propellants such as lohadrocarbon, propane/butane, or dimethyl ether. These may be used alone or in combination of two or more types.
또한, 본 발명의 제형이 용액 또는 유탁액인 경우에는, 담체 성분으로서 용매, 용해화제 또는 유탁화제 등이 이용될 수 있으며, 예를 들어 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일 등이 이용될 수 있고, 특히, 목화씨 오일, 땅콩 오일, 옥수수 배종 오일, 올리브 오일, 피마자 오일 및 참깨 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 이용될 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2종 이상 혼합되어 사용될 수 있다.In addition, when the formulation of the present invention is a solution or emulsion, a solvent, solubilizing agent, or emulsifying agent may be used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, Benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, etc. can be used, especially cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil and sesame oil, glycerol aliphatic ester, polyethylene glycol or sorbitol. Fatty acid esters of bean can be used, but are not limited thereto. These may be used alone or in combination of two or more types.
또한, 본 발명의 제형이 현탁액인 경우에는, 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타하이드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2종 이상 혼합되어 사용될 수 있다.In addition, when the formulation of the present invention is a suspension, the carrier component includes water, a liquid diluent such as ethanol or propylene glycol, and a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester. , microcrystalline cellulose, aluminum metahydroxide, bentonite, agar, or tracant may be used, but are not limited thereto. These may be used alone or in combination of two or more types.
또한, 본 발명의 제형이 비누인 경우에는, 담체 성분으로서 지방산의 알칼리 금속 염, 지방산 헤미에스테르 염, 지방산 단백질 히드롤리제이트, 이세티오네이트, 라놀린 유도체, 지방족 알코올, 식물성 유, 글리세롤, 당 등이 이용될 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2종 이상 혼합되어 사용될 수 있다.In addition, when the formulation of the present invention is soap, alkali metal salts of fatty acids, fatty acid hemiester salts, fatty acid protein hydrolysates, isethionates, lanolin derivatives, fatty alcohols, vegetable oils, glycerol, sugars, etc. are used as carrier components. may be used, but is not limited thereto. These may be used alone or in combination of two or more types.
또 다른 하나의 양태는 상기 난용성 물질을 포함하는, 의약외품 조성물을 제공한다. Another aspect provides a quasi-drug composition containing the poorly soluble substance.
상기 "난용성 물질"에 대한 설명은 전술한 바와 같다.The description of the “poorly soluble substance” is the same as described above.
본 발명의 의약외품 조성물은 수용성이 증가된 난용성 물질, 구체적으로 수용성이 증가된 커큐미노이드계 화합물을 포함하므로, 이에 의한 항산화 활성을 높은 수준으로 나타낼 수 있다.Since the quasi-drug composition of the present invention contains poorly soluble substances with increased water solubility, specifically curcuminoid compounds with increased water solubility, it can exhibit antioxidant activity at a high level.
본 발명의 용어, "의약외품"은 사람이나 동물의 질병을 진단, 치료, 개선, 경감, 처치 또는 예방할 목적으로 사용되는 물품들 중 의약품보다 작용이 경미한 물품들을 의미하는 것으로, 예를 들어 약사법에 따르면 의약외품이란 의약품의 용도로 사용되는 물품을 제외한 것으로, 사람/동물의 질병 치료나 예방에 쓰이는 제품, 인체에 대한 작용이 경미하거나 직접 작용하지 않는 제품 등이 포함된다.The term "quasi-drug" of the present invention refers to products with a milder effect than pharmaceuticals among products used for the purpose of diagnosing, treating, improving, alleviating, treating, or preventing diseases in humans or animals. For example, according to the Pharmaceutical Affairs Act, Quasi-drugs exclude products used for medicinal purposes and include products used to treat or prevent diseases in humans and animals, and products that have a mild or no direct effect on the human body.
본 발명의 의약외품 조성물은 바디 클렌저, 폼, 비누, 마스크, 연고제, 크림, 로션, 에센스 및 스프레이로 이루어진 군에서 선택되는 하나 이상으로 제조할 수 있으나, 이에 제한되지 않는다.The quasi-drug composition of the present invention may be prepared from one or more selected from the group consisting of body cleanser, foam, soap, mask, ointment, cream, lotion, essence, and spray, but is not limited thereto.
본 발명에 따른 수용성이 증가된 난용성 물질을 의약외품 첨가물로 사용할 경우, 이를 그대로 첨가하거나 다른 의약외품 또는 의약외품 성분과 함께 사용할 수 있고, 통상적인 방법에 따라 적절하게 사용할 수 있다. 유효성분의 혼합량은 사용 목적에 따라 적합하게 결정될 수 있다.When using the poorly soluble substance with increased water solubility according to the present invention as a quasi-drug additive, it can be added as is or used together with other quasi-drugs or quasi-drug ingredients, and can be used appropriately according to conventional methods. The mixing amount of the active ingredient can be appropriately determined depending on the purpose of use.
또 다른 하나의 양태는 상기 난용성 물질을 포함하는, 사료 조성물을 제공한다. Another aspect provides a feed composition containing the poorly soluble substance.
본 발명에서 사용되는 용어, "사료"는 가축이 먹고, 섭취하며, 소화시키기 위한 또는 이에 적당한 임의의 천연 또는 인공 규정식, 한끼식 등 또는 상기 한끼식의 성분을 의미한다.As used in the present invention, the term "feed" means any natural or artificial diet, meal, etc., or an ingredient of the meal, for livestock to eat, ingest, and digest, or suitable therefor.
상기 사료는 사료 첨가제 또는 보조사료를 포함할 수 있다.The feed may include feed additives or supplementary feed.
상기 사료의 종류는 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용되는 사료를 사용할 수 있다. 상기 사료의 비제한적인 예로는, 곡물류, 근과류, 식품 가공 부산물류, 조류, 섬유질류, 제약 부산물류, 유지류, 전분류, 박류 또는 곡물 부산물류 등과 같은 식물성 사료; 단백질류, 무기물류, 유지류, 광물성류, 유지류, 단세포 단백질류, 동물성 플랑크톤류 또는 음식물 등과 같은 동물성 사료를 들 수 있다. 이들은 단독으로 사용되거나 2 종 이상을 혼합하여 사용될 수 있다.The type of feed is not particularly limited, and feed commonly used in the art can be used. Non-limiting examples of the feed include plant feeds such as grains, roots and fruits, food processing by-products, algae, fiber, pharmaceutical by-products, oils and fats, starches, cucurbits or grain by-products; Examples include animal feeds such as proteins, inorganic substances, fats and oils, minerals, oils and fats, single-cell proteins, zooplanktons or foods. These may be used individually or in combination of two or more types.
또 다른 하나의 양태는 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물에서 선택된 하나 이상의 추출물을 난용성 물질과 혼합하는 단계를 포함하는, 난용성 물질의 수용성 증가 방법을 제공한다. Another aspect provides a method of increasing the water solubility of a poorly soluble substance, comprising mixing one or more extracts selected from white ginseng root extract, red ginseng root extract, and ginseng fruit extract with a poorly soluble substance.
상기 "백삼근 추출물", "홍삼근 추출물", "인삼열매 추출물" 및 "난용성 물질"에 대한 설명은 전술한 바와 같다.Descriptions of the “white ginseng root extract”, “red ginseng root extract”, “ginseng fruit extract”, and “poorly soluble substances” are the same as above.
구체적으로, 상기 방법은 상기 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물에서 선택된 하나 이상의 추출물에 마이크로웨이브(microwave)를 처리하는 단계를 추가로 포함할 수 있다.Specifically, the method may further include the step of treating one or more extracts selected from the white ginseng root extract, red ginseng root extract, and ginseng fruit extract with a microwave.
본 발명의 용어, "마이크로웨이브"는 파장의 범위가 1mm ~ 1m 사이의 전파를 의미한다. 파장이 짧으므로 빛과 거의 비슷한 성질을 갖고 있으며 살균력이 강하다는 특징이 있다. 구체적으로, 상기 마이크로웨이브는 1,500 내지 13,000W일 수 있으며, 또한 1 내지 20분 동안 처리되는 것일 수 있으나, 이에 제한되지 않는다.As used herein, the term “microwave” refers to radio waves with a wavelength ranging from 1 mm to 1 m. Because it has a short wavelength, it has properties almost similar to light and has strong sterilizing power. Specifically, the microwave may be 1,500 to 13,000 W and may be processed for 1 to 20 minutes, but is not limited thereto.
또한, 상기 혼합 및 마이크로웨이브의 처리 단계는 80 내지 100℃에서 수행될 수 있으나, 이에 제한되지 않는다.Additionally, the mixing and microwave treatment steps may be performed at 80 to 100° C., but are not limited thereto.
또 다른 하나의 양태는 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물에서 선택된 하나 이상의 추출물을 난용성 물질에 처리하는 단계를 포함하는, 수용성이 증가된 난용성 물질의 제조방법을 제공한다.Another aspect provides a method for producing a poorly soluble material with increased water solubility, comprising treating one or more extracts selected from white ginseng root extract, red ginseng root extract, and ginseng fruit extract to a poorly soluble material.
또 다른 하나의 양태는 백삼근 추출물, 홍삼근 추출물, 인삼열매 추출물에서 선택된 하나 이상의 추출물, 및 난용성 물질을 혼합 및 열수용해 하는 제1단계; 및 상기 제1단계에서 얻어진 혼합물에 마이크로웨이브(microwave)를 처리하는 제2단계를 포함하는, 수용성이 증가된 난용성 물질 함유 조성물의 제조방법을 제공한다. Another embodiment includes a first step of mixing and hot water dissolving one or more extracts selected from white ginseng root extract, red ginseng root extract, and ginseng fruit extract, and poorly soluble substances; and a second step of treating the mixture obtained in the first step with a microwave. It provides a method for producing a composition containing a poorly soluble substance with increased water solubility.
상기 "백삼근 추출물", "홍삼근 추출물", "인삼열매 추출물" 및 "난용성 물질"에 대한 설명은 전술한 바와 같다.Descriptions of the “white ginseng root extract”, “red ginseng root extract”, “ginseng fruit extract”, and “poorly soluble substances” are the same as above.
본 발명의 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물에서 선택된 하나 이상의 추출물은 난용성 물질의 수용성을 증가시킬 수 있으므로, 수용성이 증가된 난용성 물질의 제조에 유용하게 사용될 수 있다.One or more extracts selected from the white ginseng root extract, red ginseng root extract, and ginseng fruit extract of the present invention can increase the water solubility of poorly soluble substances, and thus can be usefully used in the production of poorly soluble substances with increased water solubility.
구체적으로, 상기 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물에서 선택된 하나 이상의 추출물을 난용성 물질에 처리하는 단계는, 상기 추출물을 난용성 물질과 혼합하는 단계일 수 있다. Specifically, the step of treating one or more extracts selected from the white ginseng root extract, red ginseng root extract, and ginseng fruit extract with a poorly soluble substance may be a step of mixing the extract with a poorly soluble substance.
상기 제조방법의 제1단계는 용매에서 혼합하거나, 또는 백삼근, 홍삼근 또는 인삼열매에서 선택된 하나 이상의 추출물이 포함된 용액에 난용성 물질을 첨가하는 것일 수 있다. 상기 제2단계는 1L (1500 W 이상) 내지 25L (13000 W)의 범위로 1분 내지 20분간 마이크로웨이브를 처리하는 것일 수 있다.The first step of the manufacturing method may be mixing in a solvent or adding a poorly soluble substance to a solution containing one or more extracts selected from white ginseng root, red ginseng root, or ginseng fruit. The second step may be processing the microwave for 1 to 20 minutes in the range of 1L (1500 W or more) to 25L (13000 W).
본 발명에 따른 백삼근 추출물, 홍삼근 추출물 및 인삼열매 추출물에서 선택된 하나 이상의 추출물은 난용성 물질의 수용성을 향상시킬 수 있으므로, 난용성 물질의 경구 및 주사제형으로의 제조, 저장 안정성 증가 및 약물 전달능력/체내 흡수율 증가 등에 유용하게 활용될 수 있다. 또한, 상기 추출물은 천연 유래이므로 인체에 부작용 없이 안전하게 이용될 수 있다.One or more extracts selected from white ginseng root extract, red ginseng root extract, and ginseng fruit extract according to the present invention can improve the water solubility of poorly soluble substances, thereby producing oral and injectable formulations of poorly soluble substances, increasing storage stability, and drug delivery ability/ It can be useful for increasing the absorption rate in the body. Additionally, since the extract is of natural origin, it can be safely used without side effects on the human body.
도 1은 본 발명의 일 실시에에 따라 백삼근 추출 농축액을 사용하여 커큐민을 용해한 결과로서, 상기 농축액에 용해된 커큐민의 함량을 보여주는 HPLC 크로마토그램이다.
도 2는 본 발명의 일 실시에에 따라 홍삼근 추출 농축액을 사용하여 커큐민을 용해한 결과로서, 상기 농축액에 용해된 커큐민의 함량을 보여주는 HPLC 크로마토그램이다.
도 3은 본 발명의 일 실시에에 따라 인삼열매 추출 농축액을 사용하여 커큐민을 용해한 결과로서, 상기 농축액에 용해된 커큐민의 함량을 보여주는 HPLC 크로마토그램이다.
도 4는 본 발명의 일 실시에에 따라 인삼열매 착즙 농축액을 사용하여 커큐민을 용해한 결과로서, 상기 농축액에 용해된 커큐민의 함량을 보여주는 HPLC 크로마토그램이다.Figure 1 is an HPLC chromatogram showing the content of curcumin dissolved in the concentrate as a result of dissolving curcumin using a concentrate of white ginseng root extract according to an embodiment of the present invention.
Figure 2 is an HPLC chromatogram showing the content of curcumin dissolved in the concentrate as a result of dissolving curcumin using a red ginseng root extract concentrate according to an embodiment of the present invention.
Figure 3 is an HPLC chromatogram showing the content of curcumin dissolved in the concentrate as a result of dissolving curcumin using the ginseng fruit extract concentrate according to an embodiment of the present invention.
Figure 4 is an HPLC chromatogram showing the content of curcumin dissolved in the concentrate as a result of dissolving curcumin using the ginseng fruit juice concentrate according to an embodiment of the present invention.
이하, 본 발명을 실시예를 통하여 보다 상세하게 설명한다. 그러나, 이들 실시예는 본 발명을 예시적으로 설명하기 위한 것으로 본 발명의 범위가 이들 실시예에 한정되는 것은 아니다.Hereinafter, the present invention will be described in more detail through examples. However, these examples are for illustrative purposes only and the scope of the present invention is not limited to these examples.
실시예 1. 난용성 화합물의 수용성 증진Example 1. Enhancement of water solubility of poorly soluble compounds
난용성 물질의 수용성을 증가시키기 위하여, 백삼근 추출물, 홍삼근 추출물, 인삼열매 추출물을 이용하였다. 난용성 물질의 예시로서 커큐미노이드계 화합물, 구체적으로 커큐민을 사용하였다. 상기 추출물은 농축액의 형태로 공급되어 이용하였고, 농축액은 각각 주식회사 고려원인삼 또는 주식회사 신우코퍼레이션에서 공급받아 사용하였다.To increase the water solubility of poorly soluble substances, white ginseng root extract, red ginseng root extract, and ginseng fruit extract were used. As an example of a poorly soluble substance, a curcuminoid compound, specifically curcumin, was used. The extract was supplied and used in the form of a concentrate, and the concentrate was supplied and used by Korea One Ginseng Co., Ltd. or Shinwoo Corporation Co., Ltd., respectively.
이후, 커큐민 10 내지 20%(v/v)에 대하여, 백삼근 추출 농축액, 홍삼근 추출 농축액, 인삼열매 추출 농축액 또는 인삼열매 착즙 추출 농축액을 5 내지 20%(v/v)의 비율로 넣고 혼합하였다. Afterwards, white ginseng root extract concentrate, red ginseng root extract concentrate, ginseng fruit extract concentrate, or ginseng fruit juice extract concentrate were added and mixed at a ratio of 5 to 20% (v/v) with respect to curcumin of 10 to 20% (v/v).
상기 혼합물에 마이크로웨이브(1,500 ~ 13,000W)를 10 ~ 20분간 처리하였고, 상기 혼합 및 마이크로웨이브의 처리는 모두 80 내지 100℃에서 수행하였다. 상기 혼합물에 대하여 마이크로웨이브를 처리함으로써, 기존의 추출방법에서 사용되는 용매(주정)를 사용 하지 않고 추출물을 제조할 수 있으며, 추출물의 제조에 있어서 소요되는 시간을 단축할 수 있으며, 추출공정이 축소 됨으로써 효율이 증대된다. 또한, 커큐민의 수용화에 있어서 마이크로웨이브를 이용할 경우, 수용화 효율을 높일 수 있다. 마지막으로, 수용화된 커큐민의 양을 HPLC를 이용하여 정량 하였고, 그 결과를 하기 표 1, 및 도 1 내지 4에 나타내었다.The mixture was treated with a microwave (1,500 to 13,000 W) for 10 to 20 minutes, and both mixing and microwave treatment were performed at 80 to 100°C. By treating the mixture with microwaves, an extract can be prepared without using a solvent (alcohol) used in existing extraction methods, the time required to prepare the extract can be shortened, and the extraction process can be reduced. This increases efficiency. In addition, when microwaves are used in the water solubilization of curcumin, the water solubilization efficiency can be increased. Finally, the amount of curcumin solubilized was quantified using HPLC, and the results are shown in Table 1 and Figures 1 to 4 below.
농축액White ginseng root extract
concentrate
농축액Red ginseng root extract
concentrate
농축액Ginseng fruit juice extraction
concentrate
그 결과, 상기 표 1, 및 도 1 내지 4에서 볼 수 있듯이, 커큐민을 백삼근 추출 농축액, 홍삼근 추출 농축액, 인삼열매 추출 농축액, 또는 인삼열매 착즙 추출 농축액과 혼합하는 경우, 상기 농축액(추출물)을 사용하지 않은 경우에 비하여 용해된 커큐민의 양이 증가하는 것을 확인하였다. 또한, 도 5는 커큐민을 상기의 방법으로 추출물을 사용하지 않고 정제수만으로 추출한 경우에 대한 결과로, 수용화된 커큐민이 존재하지 않는 것을 확인하였다.As a result, as can be seen in Table 1 and Figures 1 to 4, when curcumin is mixed with white ginseng root extract concentrate, red ginseng root extract concentrate, ginseng fruit extract concentrate, or ginseng fruit juice extract concentrate, the concentrate (extract) is used. It was confirmed that the amount of dissolved curcumin increased compared to the case where it was not used. In addition, Figure 5 shows the results of extracting curcumin only with purified water without using the extract using the above method, and it was confirmed that no water-soluble curcumin was present.
즉 상기 결과를 통해, 본 발명에 따른 추출물을 사용하는 경우 커큐미노이드계 화합물과 같은 난용성 물질의 수용성을 증가시킬 수 있음을 알 수 있었다.In other words, the above results showed that using the extract according to the present invention can increase the water solubility of poorly soluble substances such as curcuminoid compounds.
이상의 설명으로부터, 본 발명이 속하는 기술분야의 당업자는 본 발명이 그 기술적 사상이나 필수적 특징을 변경하지 않고서 다른 구체적인 형태로 실시될 수 있다는 것을 이해할 수 있을 것이다. 이와 관련하여, 이상에서 기술한 실시예들은 모든 면에서 예시적인 것이며 한정적인 것이 아닌 것으로서 이해해야만 한다. 본 발명의 범위는 상기 상세한 설명보다는 후술하는 특허 청구범위의 의미 및 범위 그리고 그 등가 개념으로부터 도출되는 모든 변경 또는 변형된 형태가 본 발명의 범위에 포함되는 것으로 해석되어야 한다.From the above description, those skilled in the art to which the present invention pertains will understand that the present invention can be implemented in other specific forms without changing its technical idea or essential features. In this regard, the embodiments described above should be understood in all respects as illustrative and not restrictive. The scope of the present invention should be construed as including the meaning and scope of the patent claims described below rather than the detailed description above, and all changes or modified forms derived from the equivalent concept thereof are included in the scope of the present invention.
Claims (14)
상기 백삼근 주정 추출물, 홍삼근 주정 추출물, 및 인삼열매 주정 또는 착즙 추출물은 발효물 또는 산가수분해물을 제외한 추출물인 것이고,
상기 난용성 물질은 커큐미노이드계 화합물인 것인, 조성물.
A composition for increasing the water solubility of poorly soluble substances, comprising one or more extracts selected from white ginseng root alcohol extract, red ginseng root alcohol extract, and ginseng fruit alcohol or juice extract,
The white ginseng root alcohol extract, red ginseng root alcohol extract, and ginseng fruit alcohol or juice extract are extracts excluding fermented products or acid hydrolysates,
A composition wherein the poorly soluble material is a curcuminoid-based compound.
The composition according to claim 1, wherein the white ginseng root alcohol extract, the red ginseng root alcohol extract, or the ginseng fruit alcohol or juice extract is contained in an amount of 1 to 25% (w/v) based on the total composition.
The composition of claim 1, wherein the curcuminoid compound is curcumin.
상기 난용성 물질은 커큐미노이드계 화합물인 것인, 수용성이 증가된 난용성 물질.
A poorly soluble material with increased water solubility comprising the composition of claim 1,
The poorly soluble material is a curcuminoid-based compound, and the poorly soluble material has increased water solubility.
A cosmetic composition comprising the poorly soluble substance of claim 7.
A food composition comprising the poorly soluble substance of claim 7.
A quasi-drug composition containing the poorly soluble substance of claim 7.
A feed composition comprising the poorly soluble substance of claim 7.
상기 백삼근 주정 추출물, 홍삼근 주정 추출물, 및 인삼열매 주정 또는 착즙 추출물은 발효물 또는 산가수분해물을 제외한 추출물인 것이고,
상기 난용성 물질은 커큐미노이드계 화합물인 것인, 방법.
A method of increasing the water solubility of a poorly soluble substance, comprising mixing one or more extracts selected from white ginseng root alcohol extract, red ginseng root alcohol extract, and ginseng fruit alcohol or juice extract with a poorly soluble substance,
The white ginseng root alcohol extract, red ginseng root alcohol extract, and ginseng fruit alcohol or juice extract are extracts excluding fermented products or acid hydrolysates,
The method wherein the poorly soluble material is a curcuminoid-based compound.
상기 백삼근 주정 추출물, 홍삼근 주정 추출물, 및 인삼열매 주정 또는 착즙 추출물은 발효물 또는 산가수분해물을 제외한 추출물인 것이고,
상기 난용성 물질은 커큐미노이드계 화합물인 것인, 방법.
One or more extracts selected from white ginseng root alcohol extract, red ginseng root alcohol extract, and ginseng fruit alcohol or juice extract; and a first step of mixing and dissolving poorly soluble substances in hot water; A method for producing a composition containing a poorly soluble substance with increased water solubility, comprising a second step of treating the mixture obtained in the first step with a microwave,
The white ginseng root alcohol extract, red ginseng root alcohol extract, and ginseng fruit alcohol or juice extract are extracts excluding fermented products or acid hydrolysates,
The method wherein the poorly soluble material is a curcuminoid-based compound.
The method of claim 13, wherein in the first step, one or more extracts selected from white ginseng root alcohol extract, red ginseng root alcohol extract, ginseng fruit alcohol or juice extract, and poorly soluble substances are mixed in a solvent, or white ginseng root alcohol extract, red ginseng root alcohol extract, Alternatively, the method is characterized by adding a poorly soluble substance to a solution containing ginseng fruit alcohol or juice extract.
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