KR102561297B1 - A composition for promoting hair growth containing sprout barley and natural substances as an active ingredient - Google Patents

Abstract

The present invention is a composition for promoting hair growth or preventing hair loss containing an extract of barley sprouts, extract of barley sprouts, calcium pantothenate, vitamin C, iron, zinc, vitamin E, vitamin D, biotin, L-cysteine hydrochloride, L-cystine, magnesium , It relates to a composition for promoting hair growth or preventing hair loss, comprising dried brewer's yeast, Schisandra chinensis extract, tangerine peel extract, magnesium stearate, lactic acid bacteria, and hydroxypropylmethylcellulose.

Description

A composition for promoting hair growth containing barley sprouts and natural substances as active ingredients

The present invention relates to a composition containing sprout barley and natural substances as active ingredients, and specifically, contains nutrients such as sprout barley extract, vitamins and minerals, and can promote hair growth and prevent hair loss by taking them.

Sprout barley contains chlorophyll, which is an antioxidant enzyme and has the same molecular structure as hemoglobin, so it is known to be effective in blood circulation, inflammation relief, edema, etc., and is reported to promote cell regeneration. In addition, sprouted barley is rich in polyphenols and policosanol, which prevents the production of neutral fat in the body and helps in lipolysis, so it is consumed as a diet food. In addition, the saponarin component plays a role in discharging glucose from being stored as fat in the body, and the calorie content is only 32 kcal per 100 g, so there is no burden when taking it.

On the other hand, hair loss is one of the distressing experiences of both men and women worldwide, and includes stress-induced alopecia areata, androgenetic alopecia, and senescent telogen hair loss that appear as the hair growth cycle enters the telogen phase, which can occur regardless of gender. Even if you look at the data of the National Health Insurance Corporation, a quasi-governmental organization rather than an individual's experience, 44% of patients visiting a hospital for hair loss accounted for nearly half of all hair loss patients in their 20s and 30s. Even if it's about 20 years old, it's about 20 %, so it's not just a problem of middle-aged people. However, hair loss can only be prevented, and there is no treatment that can be expected to grow hair in reality. Hair loss prevention drugs include male hormone regulators such as finasteride and chemical ingredients such as minoxidil, scalp application agents, and the like, all of which contain chemical ingredients and users are reluctant to take or use them for a long time. Accordingly, there is a need for safe hair loss prevention or treatment using natural ingredients.

Korean Patent Registration No. 10-2022-0023439 discloses the hair loss prevention effect of barley sprouts, but there is no comparison with existing formulations and the effect of combining barley sprouts with other ingredients is not disclosed.

One aspect is a composition for promoting hair growth or preventing hair loss containing an extract of sprout barley, extract of sprout barley, calcium pantothenate, vitamin C, iron, zinc, vitamin E, vitamin D, biotin, L-cysteine hydrochloride, L-cystine, magnesium , It provides a composition for promoting hair growth or preventing hair loss, comprising dried brewer's yeast, Schisandra chinensis extract, tangerine peel extract, magnesium stearate, lactic acid bacteria, and hydroxypropylmethylcellulose.

Another aspect provides a health functional food, cosmetic, quasi-drug or pharmaceutical composition containing the composition for promoting hair growth or preventing hair loss.

Hereinafter, various embodiments of the present invention are described. It should be understood that the present invention is not limited to specific embodiments, and includes various modifications, equivalents, and/or alternatives of the embodiments of the present invention. In connection with the description of the drawings, like reference numerals may be used for like elements.

In this document, expressions such as "has", "may have", "includes", or "may include" refer to the presence of a corresponding feature (eg, numerical value, function, operation, or component such as a part). , which does not preclude the existence of additional features.

In this document, expressions such as "A or B", "at least one of A and/and B", or "one or more of A or/and B" may include all possible combinations of the items listed together. . For example, "A or B", "at least one of A and B", or "at least one of A or B" includes (1) at least one A, (2) at least one B, Or (3) may refer to all cases including at least one A and at least one B.

The expression "configured to" as used in this document means, depending on the circumstances, e.g. "Suitable for", "Having the capacity to" ", "Designed to", "Adapted to", "Made to", or "Capable of" may be used interchangeably. The term "configured (or set) to" does not necessarily mean "specifically designed to."

Terms used in this document are only used to describe a specific embodiment, and may not be intended to limit the scope of other embodiments. Singular expressions may include plural expressions unless the context clearly dictates otherwise. Terms used herein, including technical or scientific terms, may have the same meaning as commonly understood by a person of ordinary skill in the technical field described in this document. Among the terms used in this document, the terms defined in general dictionaries may be interpreted as having the same or similar meaning to the meaning in the context of the related art, and unless explicitly defined in this document, in an ideal or excessively formal meaning. not interpreted In some cases, even terms defined in this document cannot be interpreted to exclude the embodiments of this document.

The embodiments disclosed in this document are presented for explanation and understanding of the disclosed technical content, and do not limit the scope of the present invention. Therefore, the scope of this document should be construed to include all changes or various other embodiments based on the technical idea of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail. Prior to this, the terms or words used in this specification and claims should not be construed as being limited to the usual or dictionary meaning, and the inventor appropriately uses the concept of the term in order to explain his/her invention in the best way. It should be interpreted as a meaning and concept consistent with the technical idea of the present invention based on the principle that it can be defined.

Therefore, since the configurations of the embodiments described in this specification are only some of the most preferred embodiments of the present invention and do not represent all of the technical spirit of the present invention, various equivalents and modifications that can replace them at the time of this application It should be understood that there may be

Throughout the specification, when a certain component is said to "include", it means that it may further include other components without excluding other components unless otherwise stated.

In one aspect of the present disclosure, the term "about" is used with the intention of including a slight numerical adjustment that falls within the scope of a manufacturing process error included in a specific value or the scope of the technical spirit of the present disclosure. For example, the term “about” means a range of ±10%, in one aspect ±5%, and in another aspect ±2% of the value to which it refers.

Hereinafter, the present invention will be described in detail.

One aspect is a composition for promoting hair growth or preventing hair loss containing an extract of sprout barley, 10-20 w/w% of barley sprout extract, 12-16 w/w% calcium pantothenate, 10-15 w/w% vitamin C, Iron 2-5w/w%, Zinc 1-3w/w%, Vitamin E 1-3w/w%, Vitamin D 1-3w/w%, Biotin 0.1-1w/w%, L-cysteine hydrochloride 8-12w/ w%, L-cystine 1-5w/w%, Magnesium 1-5w/w%, Dried beer yeast 1-5w/w%, Schisandra chinensis extract 1-5w/w%, Tangerine peel extract 1-5w/w%, 1-5 w/w% of magnesium stearate, 1-5 w/w% of lactic acid bacteria, and 0.1-1 w/w% of hydroxypropylmethylcellulose.

More specifically, the composition for promoting hair growth or preventing hair loss contains 14-16 w/w% of sprout barley extract, 14-15 w/w% of calcium pantothenate, 11-12 w/w% of vitamin C, and 2-3 w/w of iron, based on the weight of the total composition. %, zinc 1-2w/w%, vitamin E 1-2w/w%, vitamin D3 1-2w/w%, biotin 0.1-1w/w%, L-cysteine hydrochloride 9-11w/w%, L-cystine 4-6w/w%, magnesium 4-6w/w%, dried beer yeast 1-2w/w%, Schisandra chinensis extract 1-3w/w%, tangerine peel extract 1-2w/w%, magnesium stearate 1-2w/ w%, 1-3 w/w% of lactic acid bacteria, and 0.1-0.3 w/w% of hydroxypropylmethylcellulose.

The lactic acid bacteria may include a combination of Bifidobacterium animalis ssp lactis, Lactobacillus plantarum, and Lactobacillus rhamnosus, but is not limited thereto. Each lactic acid bacteria may be mixed in a weight ratio of 4:3:3.

The composition for promoting hair growth or preventing hair loss may further include 12-28 w/w% of crystalline cellulose, preferably 12-18 w/w%, as a weight ratio. In one embodiment, the composition for promoting hair growth or preventing hair loss may further include 2-5w/w% citric acid and 2-5w/w% sorbitol, in addition to crystalline cellulose. The composition of the present invention can achieve a certain level of stability by adjusting the content of the sprout barley extract itself, but crystalline cellulose, citric acid and sorbitol can further increase the stability of the composition. Citric acid may affect the acidity of the entire composition, and since stability may be greatly affected by acidity due to the nature of using natural products as raw materials, stability may rather decrease if it is out of the above range.

Since the solubility or stability of the sprout barley extract may vary depending on the manufacturing method, it may be preferable to use an extract extracted by a certain manufacturing method.

A method for producing an extract of barley sprouts according to one embodiment includes: 1) hot water extracting barley sprouts at 90-110 ° C. for 2-4 hours; 2) adding C1 to C4 lower alcohol to the hot water extract and removing the precipitate; 3) adding polyethylene glycol and maltodextrin to the hot water extract and adjusting the pH to 5.5 to 6.5; and 4) heating the hot water extract at 90-110° C. for 2-4 hours, and then lyophilizing and pulverizing the extract.

In step 1), the ratio of sprout barley and water for hot water extraction may be 1:5.0 to 7.0. For example, hot water extraction may be performed by adding 5L to 7L of water to 1kg of sprout barley and then heating. It may be desirable to conduct hot water extraction in a semi-permeable vessel to minimize loss of aromatic nutrients.

In the method for preparing the barley sprout extract, the lower alcohol may be added to a concentration of 8w/w% to 12w/w%. The lower alcohol is important in increasing the solubility of the final product by precipitating and removing particles that are not yet filtered and are present in suspension. Lower alcohols include, but are not limited to, ethanol, isopropanol, butanol, and the like. Preferably, the lower alcohol may be ethanol.

After adding the lower alcohol, leaving the mixture to stand, collecting the supernatant, and filtering it once again to remove floating precipitates. By removing particles of 100 nm or more by ultrafiltration, the water solubility of the powder after lyophilization can be increased and the storage stability can be further increased.

In the sprout barley extract manufacturing method, the polyethylene glycol and maltodextrin may be added in an amount of 5-10 w/w%, respectively, based on the weight of the hot water extract. Polyethylene glycol and maltodextrin additionally heat the sprouted barley extract, minimize changes in properties and destruction of nutrients under harsh conditions such as freeze-drying, and also affect storage stability of the final product. The content of polyethylene glycol and maltodextrin is sufficient at about 5-10 w/w%, and when added more than that, it results in dilution of the active ingredient of the barley sprout extract, so it is appropriate to use it within a certain range.

It may be desirable to adjust the pH of the hot water extract to 5.5 to 6.5 before further heating in step 3). It may be desirable to adjust the pH with a weak acid such as acetic acid. By adjusting the pH, it is possible to reduce the bitter taste or smell peculiar to sprout barley extract.

When preparing the sprouted barley extract, it is preferable to remove some of the lower alcohol by additionally heating at about 100° C. for about 3 hours before freeze-drying. During freeze-drying, some of the active ingredients may change as the barley sprout extract is exposed to alcohol for a long time, and storage stability can be increased by minimizing the remaining amount of alcohol.

When freeze-drying the barley sprout extract in step 4), it is preferable to dry it enough to be powdered, and if necessary, it can be formulated into granules, pills, or tablets by mixing conventionally known excipients.

Since sprout barley extract is a concentrate isolated from natural products and contains a high amount of minerals, the rate of deterioration may be accelerated when contacted with acid or an additional large amount of minerals. Therefore, when additional nutritional ingredients are mixed to make a composition for promoting hair growth or preventing hair loss, the content of sprout barley extract is adjusted to 10-20w/w% of the total composition, and minerals such as iron and magnesium and vitamin C and The amount of the same acidic ingredient should be adjusted.

A composition for promoting hair growth or preventing hair loss according to one aspect may be provided as a health functional food, cosmetic, quasi-drug, or pharmaceutical composition.

The term "health functional food" used in the present invention refers to all foods manufactured and processed in the form of liquid, tablet, capsule, powder, granule, pill, etc. using raw materials or ingredients having useful functionality for the human body. The health functional food of the present invention can be prepared by a method commonly used in the art, and can be prepared by adding raw materials and components commonly added in the art during the preparation. "Function" means designed to exert useful physiological effects on the structure and function of the human body, such as biological defense, regulation of biological rhythm, prevention, improvement and recovery of disease.

The formulation of the health functional food may be manufactured without limitation as long as it is a formulation recognized as food. For example, beverages, tablets, powders, pills, meat, sausages, bread, chocolates, candies, snacks, confectionery, pizza, ramen, other noodles, chewing gum, dairy products including ice cream, various soups, beverages, tea, drinks, alcoholic beverages and vitamin complexes, but are not limited thereto.

When the composition of the present invention is used as a cosmetic, it may be prepared in any formulation commonly prepared in the art, for example, a solution, suspension, emulsion, paste, gel, cream, lotion, powder, oil, It may be formulated as a powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it may be prepared in the form of sun cream, softening lotion, astringent lotion, nourishing lotion, nourishing cream, massage cream, essence, eye cream, pack, spray or powder. When the formulation is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. . When the formulation is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydrocarbon, propane/butane or a propellant such as dimethyl ether. When the formulation is a solution or emulsion, a solvent, solubilizing agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3 -Butyl glycol oil, fatty acid esters of glycerol, polyethylene glycol or sorbitan. When the formulation is a suspension, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline cellulose as a carrier component , aluminum metahydroxide, bentonite, agar or tracanth, and the like can be used.

The term “quasi-drugs” refers to textiles, rubber products, or similar products used for the purpose of treating, mitigating, treating or preventing human or animal diseases, devices or machines that have weak effects on the human body or do not directly act on the human body. Products used for the purpose of diagnosing, treating, mitigating, treating, or preventing human or animal diseases, which fall under one of the categories of products used for sterilization, insecticidal, and similar purposes for the prevention of infectious diseases and similar products. Among the items that are not instruments, machines or devices, and items used for the purpose of pharmacologically affecting the structure and function of humans or animals, items other than those that are not instruments, machines or devices. When the composition of the present invention is used as a quasi-drug, the composition may be added as it is or used together with other quasi-drugs or quasi-drug ingredients, and according to conventional methods, for example, abrasives, wetting agents, binders, foaming agents, sweeteners, preservatives, medicinal Ingredients, flavors, pigments, solvents, brighteners, solubilizers or pH adjusters may be further mixed and used. The mixing amount of the active ingredient may be appropriately determined depending on the purpose of use.

When the composition is used as a pharmaceutical composition, it may additionally contain a pharmaceutically or physiologically acceptable carrier. The carrier may be one or more selected from excipients, diluents, fillers, extenders, binders, lubricants, wetting agents, disintegrants, stabilizers, preservatives, and surfactants. Such carriers include, for example, lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, gum acacia, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. When the composition of the present invention is used as a solid dosage form for oral administration, the dosage form may be in the form of tablets, pills, powders, granules, capsules, sachets, and the like. Such solid dosage forms may include one or more pharmaceutically or physiologically acceptable excipients, such as diluents, glidants, binders, disintegrants, sweeteners, stabilizers, or preservatives, along with the compositions of the present invention. Specifically, lactose, corn starch, gelatin, calcium carbonate, soybean oil, microcrystalline cellulose, or mannitol may be used as the diluent, magnesium stearate or talc as the lubricant, and polyvinylpyrrolidone or hydroxypropyl cellulose as the binder. there is. In addition, carboxymethyl cellulose calcium, sodium starch glycolate, polyacrylic acid potassium, or crospovidone as a disintegrant, sucrose, fructose, sorbitol, or aspartame as a sweetener, carboxymethyl cellulose sodium, beta-cyclodextrin as a stabilizer, Pewter, or xanthan gum, and methyl p-oxybenzoate, propyl p-oxybenzoate, or potassium sorbate may be used as preservatives. When the pharmaceutical composition of the present invention is provided as an oral liquid dosage form, the dosage form may be in the form of a suspension, internal solution, emulsion, syrup, or elixir. In addition to water and liquid paraffin, which are commonly used simple diluents, various excipients such as wetting agents, sweeteners, aromatics, and preservatives may be included. In addition, in order to enhance the taste as a known additive in addition to the above components, natural flavors such as plum flavor, lemon flavor, pineapple flavor, and herb flavor, natural pigments such as natural fruit juice, chlorophyllin, and flavonoids, fructose, honey, sugar alcohol, and sugar It may be used by mixing a sweetening ingredient such as or an acidulant such as citric acid or sodium citrate.

The composition according to one aspect can promote hair growth, and as confirmed in the test examples of the present invention, since the hair growth promoting effect can be obtained even after administration in advance, it can be used as a hair growth promoter and hair loss prevention.

In addition, since the composition according to one aspect is made of safe ingredients, it is suitable for health functional foods, cosmetic compositions, quasi-drugs, and pharmaceuticals, and has excellent storage stability, so it is easy to store and distribute.

Figure 1 compares the hair growth state on the 10th day of administration with images. (Upper left: control group 1 / upper right: control group 2 / lower: experimental group 1)
Figure 2 is an image magnified by 250 times the hair growth state on the 10th day of administration. (Upper left: control group 1 / upper right: control group 2 / lower: experimental group 1)
Figure 3 compares the hair growth state by image on the 12th day of administration. (Upper left: control group 1 / upper right: control group 2 / lower: experimental group 1)
Figure 4 is an image magnified by 250 times the hair growth state on the 12th day of administration. (Upper left: control group 1 / upper right: control group 2 / lower: experimental group 1)
Figure 5 compares the hair growth state on the 14th day of administration by image. (Upper left: control group 1 / upper right: control group 2 / lower: experimental group 1)
Figure 6 is an image magnified by 250 times the hair growth state on the 14th day of administration. (Upper left: control group 1 / upper right: control group 2 / lower: experimental group 1)

Hereinafter, the present invention will be described in more detail by the following examples. However, the present invention is not limited by these examples.

Preparation Example 1: Preparation of sprout barley extract

After washing the sprouted barley three times, in a state where water was removed, 5 L of water was added based on 1 kg, and hot water extraction was performed by heating at about 100 ° C. for 3 hours. Ethanol was added to the hot-water extract to a concentration of 10 w/w%, mixed, and left to stand. The resulting precipitate was removed by ultrafiltration. Polyethylene glycol and maltodextrin were added in an amount of 10 w/w%, respectively, based on the weight of the hot water extract, and the pH was adjusted to about 6.0 using acetic acid. Then, after heating at about 100 ° C. for 3 hours, the extract was obtained after freeze-drying sufficiently to enable powderization.

Test Example 1: Formulation stability test

Components of the hair nutrient according to one embodiment are shown in Table 1 below. The sprouted barley extract was used as prepared in Preparation Example 1, and the three lactic acid bacteria were Bifidobacterium animalis ssp lactis, Lactobacillus plantarum, and Lactobacillus rhamnosus ) was used in a mixture of 4:3:3 weight ratio. In Example 3, citric acid and sorbitol were used as organic acids and sugar alcohols, and in Example 4, fumaric acid and mannitol were used.

3 g of each example was taken in dry powder form, put into a semi-permeable container, stored at 40 ± 2 ° C and 25 ± 5% relative humidity for 3 months, and then the main components (sum of unsaturated fatty acids and saturated fatty acids) before and after the accelerated test As criteria for rancidity, pH, color, and odor, trimethylamine and the degree of solubility change were confirmed and summarized in Table 1 below. Solubility was confirmed by putting 1g of each example in 200ml of water at 25 ° C., mixing using a vortex for 30 seconds, and then leaving it at room temperature for 10 minutes.

The results are shown in Table 2 below.

Ingredient name (mixing ratio w/w%) Example 1 Example 2 Example 3 Example 4 sprout barley extract 15.00% 25.00% 15.00% 15.00% Calcium Pantothenate 14.50% 9.50% 14.50% 14.50% vitamin C 11.94% 6.94% 11.94% 11.94% iron content 2.34% 2.34% 2.34% 2.34% zinc 1.88% 1.88% 1.88% 1.88% Vitamin E Mixture 1.65% 1.65% 1.65% 1.65% Vitamin D3 Mixture 1.25% 1.25% 1.25% 1.25% biotin 0.17% 0.17% 0.17% 0.17% crystalline cellulose 21.08% 21.08% 15.08% 15.08% L-cysteine hydrochloride 10% 10% 10% 10% L-Cystine 5% 5% 5% 5% magnesium 5% 5% 5% 5% dried brewer's yeast 2% 2% 2% 2% Schisandra chinensis Extract Powder 2% 2% 2% 2% Tangerine Peel Extract Powder 2% 2% 2% 2% Magnesium Stearate One% One% One% One% 3 types of mixed lactic acid bacteria 3% 3% 3% 3% Hydroxypropylmethylcellulose 0.20% 0.20% 0.20% 0.20% organic acid - - 3.00% 3.00% sugar alcohol - - 3.00% 3.00% total 100.00% 100.00% 100.00% 100.00%

Example 1 Example 2 Example 3 Example 4 fatty acid rancidity 3.66% 7.96% 1.72% 5.38% pH change 2.10% 8.20% 1.01% 2.11% color change doesn't exist browning doesn't exist browning Lupulon (bitter ingredient) 0.01 mg 0.78 mg 0.01mg 0.13mg solubility complete dissolution precipitation occurs complete dissolution complete dissolution

Addition of hair nutrients showed a slight decrease in overall stability. In particular, Example 2, in which the content of sprout barley extract was high, showed a significant decrease in stability. However, storage stability increased again when organic acids and sugar alcohols were added, and the combination of citric acid and sorbitol showed the greatest effect on storage stability.

Test Example 4: Hair growth test

C57BL/6N 6-week-old mice were divided into 4 groups, control group 1 diluted with 0.25 ml of distilled water, control group 2 diluted with 50 mg of Pancidil (Dongkuk Pharmaceutical) in 0.25 ml of distilled water, and experimental group 1 with distilled water in 0.25 ml of Example 1. A 12.5 mg diluted solution was orally administered once a day. Other meals were self-rationed. On the 8th day after the test material was administered for 7 days, the hair on the back of the rat was depilated using a hair removal agent (veet rasera hair removal gel cream / oxyreckit Beckinger), and on the 10th day based on the administration date of the test material On the day, the 12th day, and the 14th day, a 1x magnification photograph of the hair removal site and a 200x magnification digital microscope (Digital macro scope MS-0200 / MOSTEC) were observed.

As a result, from the 10th day of administration, it was observed that the entire hair removal area of Experimental Group 1 turned black (FIG. 1 and FIG. 2). On the 12th day of administration, control group 1 and control group 2 also observed that the entire shaved area turned black, but experimental group 1 showed clearer hair growth and the longest hair growth (FIGS. 3 and 4). On the 14th day of administration, clear hair growth was observed in both control group 2 and experimental group 1, and mice with long hair were observed in control group 2, but the number of mice with healthy hair was higher in experimental group 1.

Claims (5)

A composition for promoting hair growth or preventing hair loss containing an extract of sprout barley,
Sprout barley extract 14-16w/w%, calcium pantothenate 14-15w/w%, vitamin C 11-12w/w%, iron 2-3w/w%, zinc 1-2w/w%, vitamin E relative to the weight of the total composition 1-2w/w%, Vitamin D3 1-2w/w%, Biotin 0.1-1w/w%, L-cysteine hydrochloride 9-11w/w%, L-cystine 4-6w/w%, Magnesium 4-6w/ w%, dried beer yeast 1-2w/w%, Schisandra chinensis extract 1-3w/w%, tangerine peel extract 1-2w/w%, magnesium stearate 1-2w/w%, lactic acid bacteria 1-3w/w%, hydrogel Contains 0.1-0.3w/w% of hydroxypropylmethylcellulose, 12-18w/w% of crystalline cellulose, 2-5w/w% of citric acid and 2-5w/w% of sorbitol,
The lactic acid bacteria are a mixture of Bifidobacterium animalis ssp lactis, Lactobacillus plantarum, and Lactobacillus rhamnosus in a weight ratio of 4:3:3,
Characterized in that the citric acid and sorbitol are included for formulation stability,
A composition for promoting hair growth or preventing hair loss.
delete ◈Claim 3 was abandoned when the registration fee was paid.◈ The method of claim 1,
The sprout barley extract,
1) hot water extraction of sprouted barley at 90-110 ° C for 2-4 hours;
2) adding ethanol to the hot water extract to a concentration of 8 w/w% to 12 w/w%, and removing precipitates;
3) adding polyethylene glycol and maltodextrin to the hot-water extract in an amount of 5-10 w/w% based on the weight of the hot-water extract, and adjusting the pH to 5.5 to 6.5 using acetic acid; and
4) A composition for promoting hair growth or preventing hair loss, which is prepared by a method for producing a barley sprout extract comprising heating the hot water extract at 90-110 ° C. for 2-4 hours and then freeze-drying it. A health functional food for promoting hair growth or preventing hair loss, comprising the composition of claim 1. A cosmetic for promoting hair growth or preventing hair loss, comprising the composition of claim 1.