CN102755399A - Traditional Chinese medicine composition for resisting coccidiosis - Google Patents
Traditional Chinese medicine composition for resisting coccidiosis Download PDFInfo
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- CN102755399A CN102755399A CN2012102799058A CN201210279905A CN102755399A CN 102755399 A CN102755399 A CN 102755399A CN 2012102799058 A CN2012102799058 A CN 2012102799058A CN 201210279905 A CN201210279905 A CN 201210279905A CN 102755399 A CN102755399 A CN 102755399A
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Abstract
The invention belongs to pure traditional Chinese medicine oral solutions and discloses a traditional Chinese medicine composition for resisting coccidiosis. The traditional Chinese medicine composition is composed of the following Chinese herbal medicine raw materials by part of weight: 290-310 parts of artemisia apiacea, 290-310 parts of antipyretic dichroa, 195-205 parts of root of Chinese pulsatilla and 195-205 parts of astragalus membranaceus. The traditional Chinese medicine composition for resisting coccidiosis is suitable for diseases of coccidiosis, and is fast and good in curing effect proved by the experiment, and is free of medicine residual compared with western medicines and free of side and toxic effects.
Description
Technical field
The present invention relates to the disease-resistant Chinese medicine composition of birds, particularly relating to a kind of is the medicine of the anti-chicken coccidiosis processed of raw material with the Chinese herbal medicine.
Background technology
Chicken coccidiosis is a kind of important parasitic disease of chicken, takes place with popular very extensive, and according to the FAD report, almost all there is the generation of coccidiosis in each country in the world, and must there be the existence of chicken coccidiosis in every place that chicken is arranged.At present by 7 kinds of chicken coccidiosiss of generally acknowledging in the world: Eimeria tenella (Eimeria tenella), murder by poisoning Eimeria (E. mecatrix), Eimeria maxima (E.maxima), heap type Eimeria (E.acervalina), Bu Shi Eimeria (E.brunetti), gentle Eimeria (E.mitis) and precocious Eimeria (E.praecox) all exist in China, and wherein preceding 5 kinds have stronger pathogenicity.In various fowl disease, the sickness rate of coccidiosis is the highest, can reach 50 ~ 70%, and during severe infections, sickness rate reaches 100%, and mortality rate is up to 80%, and coccidiosis makes poultry husbandry cause enormous economic loss.The main poultry of the U.S. in 1975, because the economic loss that coccidiosis causes surpasses 1,200,000,000 dollars, Mc Donnald estimated in 1984, the whole world is used to prevent the medicine expense of coccidiosis to reach 2,800,000,000 dollars every year.Though China is precise statistics not; But show from the related data of having delivered about the coccidiosis aspect; Along with the fast development of poultry husbandry and the raising of intensive culture degree, the generation of chicken coccidiosis and harm have been one of problem that the utmost point is paid close attention in the poultry husbandry over nearly more than 30 years.
Because long-term frequent repeatability is used the medical treatment chicken coccidiosis; Domestic many areas find that the chicken coccidiosis has produced serious drug resistance to commercially available most of anticoccidial drugs; Not only conventional effective dose can not be controlled the generation of coccidiosis, even double or excess is used and also to be difficult to gather effect.This situation is at poultry husbandry flourishing area such as provinces and regions ubiquities such as Guangdong, Guangxi, Shandong, Henan, Liaoning, Jilin and Shanxi.Make poultry husbandry constantly be subjected to economic loss.In fact; The chemical sproof generation of chicken coccidiosis has been worldwide problem; Countries in the world all exist, because coccidiosis as all primary parasite, very easily produces drug resistance to medicine; Though on chicken coccidiosis Prevention Technique and method, recommend to make the way that medicament is rotated or multiple medicine is used alternatingly, these a series of appearance speed of preventing and treating method and failing to stop drug-resistant worm plant.Owing to a kind of new anticoccidial drug of research and development and up to supplying the city; Need for many years; And it is costly; Some have imagination or plan that the enterprise of research and development ability and condition has abandoned researching and developing new anticoccidial basically both at home and abroad, occur so on veterinary drug market, identify a kind of new anticoccidial drug over nearly more than 20 years.
Contain multiple nutrients composition and native chemical composition in the Chinese herbal medicine; Like vitamin, mineral, trace element etc., its effect is many target spots, when preventing and curing diseases; Can also growth promotion; Increasing the immune function of animal, improve the animal economy resistance against diseases, is the unification of nutritive value and medical value.In recent years, the inventor utilizes China's abundant Chinese herbal medicine resource exploitation Anticoccidiosis pharmaceutical composition, and through a series of tests, filtering out with Herba Artemisiae Annuae, Radix Dichroae is the compound formulation that principal agent is formed, and has obtained obvious effects.
Summary of the invention
The purpose of this invention is to provide a kind of anti-chicken coccidiosis Chinese medicine composition, its curative effect is fast, good effect, and the medicine of non-evident effect.
Anti-chicken coccidiosis Chinese medicine composition of the present invention is made up of following mass parts herbal raw material: Herba Artemisiae Annuae 290-310, Radix Dichroae 290-310, Radix Pulsatillae 195-205, Radix Astragali 195-205.
Further, the mass parts of each crude drug is in the anti-chicken coccidiosis Chinese medicine composition of the present invention: Herba Artemisiae Annuae 300, Radix Dichroae 300, the Radix Pulsatillae 200, the Radix Astragali 200.
In the prescription of the present invention, Radix Dichroae has parasite killing, expectorant, removing food stagnancy, the function of treatment coccidiosis; Herba Artemisiae Annuae yin nourishing, heat clearing away are dispelled vexed, and clearing away summer-heat, reducing the asthenic fever, protozoacide cure mainly babesiasis, coccidiosis etc.; Radix Pulsatillae astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, cure mainly have blood in stool, dysentery, malaria, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia; Radix Astragali invigorating QI to consolidate the body surface resistance, expelling pus and promoting granulation cure mainly that the body sweating due to debility goes out, blood deficiency etc.The principal agent Radix Dichroae Herba Artemisiae Annuae worm of killing, the intestinal bleeding that the treatment of the accessory drugs Radix Pulsatillae causes because of coccidiosis, the Radix Astragali fills blood, and cooperation recovers body constitution, builds up resistance.
Anti-chicken coccidiosis Chinese medicine composition of the present invention can be prepared into various dosage forms, and preferred for preparation becomes Chinese medicine oral liquid.Its preparation method is that above-mentioned raw material of Chinese medicine is cleaned, cuts into slices, grinds, soak 2 hours, decoct three times, collecting decoction, filtration, concentrate, precipitate with ethanol, filtration, form with the pure water modulation.Contain Herba Artemisiae Annuae 290-310g, Radix Dichroae 290-310g, Radix Pulsatillae 195-205g, Radix Astragali 195-205g in every 1000ml Chinese medicine oral liquid.
Anti-chicken coccidiosis Chinese medicine composition of the present invention is applicable to the disease of chicken coccidiosis, evidence, and curative effect is fast, good effect.Medicine of the present invention belongs to pure Chinese medicinal preparation, compares no drug residue with Western medicine, has no side effect.
Clinical experiment report
Test method: certain chicken house is selected for use with a collection of 200 healthy baby chicks; Public female half and half, body weight evenly, without any vaccine immunities such as chicken coccidiosis Seedlings; Online flat supporting under the condition of clean ventilation fed the mixed feed and the cleaning tap water that do not add antibiotic, coccidiostat, free choice feeding.During raising to 25 age in days, be divided into 6 groups at random, 30 every group, the 1st group is the normal healthy controls group; 2-6 group artificial challenge Eimeria tenella, behind the infection 48h, the 2nd group is made as infection and does not treat matched group; The 3rd group with 6ml/ dosage of anti-chicken coccidiosis Chinese medicine oral liquid oral liquid of the present invention and the mixed drink of cleaning tap water, successive administration 5 days; The 4th group with 3ml/ dosage of anti-chicken coccidiosis Chinese medicine oral liquid oral liquid of the present invention and the mixed drink of cleaning tap water, successive administration 5 days; The 5th group with 1.5ml/ dosage of anti-chicken coccidiosis Chinese medicine oral liquid oral liquid of the present invention and the mixed drink of cleaning tap water, successive administration 5 days; Press 0.5g/L water preparation amount with medicine diclazuril at present commonly used for the 6th group and mix drink, successive administration 5 days with the cleaning tap water.Investigate survival rate, average weight gain, the relative weight gain rate, hemafecia score, pathological changes value, egg capsule value and the anticoccidial index of each group.
The evaluation index of anti-chicken coccidiosis Chinese medicine composition curative effect:
As index, calculate anticoccidial index (ACI)=(the relative weight gain rate+survival rate) * 100-(pathological changes value+egg capsule value) with survival rate, rate of body weight gain, pathological changes value, egg sac number and the hemafecia score etc. of chickling by following formula.
Anticoccidial index＞180 are efficient anticoccidial drug; Anticoccidial index 160-180 person is middle effect anticoccidial drug; Anticoccidial index 120-160 person is the poor efficiency anticoccidial drug; Anticoccidial index＜120 are invalid anticoccidial drug.
Result of the test is seen table 1.
The clinical trial that table 1 medicine of the present invention is sick to Eimeria Tenella
| Group | Supply examination chicken (only) | Survival rate (%) | The anticoccidial index | Average weight gain (g) | The relative weight gain rate (%) | The hemafecia score | The pathological changes value | The egg capsule value |
| 1 | 30 | 100.0 | 200.0 | 159.7 | 100.0 | 0 | 0 | 0 |
| 2 | 30 | 53.3 | - | 45.0 | 28.2 | 4 | 40 | 40 |
| 3 | 30 | 90.0 | 184.7 | 150.7 | 94.7 | 0 | 0 | 0 |
| 4 | 30 | 83.3 | 165.9 | 149.4 | 93.6 | 1 | 10 | 1 |
| 5 | 30 | 70.0 | 126.7 | 138.5 | 86.7 | 2 | 20 | 10 |
| 6 | 30 | 80.0 | 162.0 | 148.6 | 93.0 | 1 | 10 | 1 |
His-and-hers watches 1 result of the test is carried out statistical results show; Two indexs of survival rate and anticoccidial index are: healthy group (1) utmost point is significantly higher than medicine high dose group of the present invention (3); High dose group (3) utmost point is significantly higher than dose groups in the medicine of the present invention (4) and present common drug diclazuril group (6), and medicine low dose group of the present invention (5) utmost point is significantly higher than infection and does not treat group (2), extremely significantly is lower than dose groups in the medicine of the present invention (4) and present common drug diclazuril group (6) again; Two indexs of average weight gain and the relative weight gain rate are: healthy group (1) utmost point is significantly higher than medicine high dose group of the present invention (3), middle dose groups (4) and diclazuril group (6); Difference between high dose group (3), middle dose groups (4) and diclazuril group (6) three is not remarkable; But the utmost point is significantly higher than medicine low dose group of the present invention (5), and low dose group (5) utmost point is significantly higher than infection and does not treat group (2); See from hemafecia score, pathological changes value, three indexs of egg capsule value; Healthy group (1) and medicine high dose group of the present invention (3) are zero; In the value of dose groups (4) and diclazuril group (6) equate that medicine low dose group of the present invention (5) is superior to infecting does not treat group (2) but than the value height of diclazuril group (6).
Judge that from the anticoccidial index anticoccidial index of common drug diclazuril group is 162.0 at present, imitate anticoccidial drug in belonging to, and the anticoccidial index of the high dose group of medicine of the present invention is 184.7, reaches efficient anticoccidial drug level; The anticoccidial index of middle dose groups is 165.9, is middle effect anticoccidial drug.The result shows, adopts height, the middle dosage of medicine of the present invention that the Eimeria Tenella disease is had good effect.
The specific embodiment
Embodiment 1
Get 30 kilograms of Herba Artemisiae Annuaes, 30 kilograms of Radix Dichroaes, 20 kilograms of the Radix Pulsatillaes, 20 kilograms of the Radixs Astragali clean, cut into slices, grind, soak 2 hours, decoct three times, collecting decoction, filtration, concentrate, precipitate with ethanol, filtration, process 100 liters of anti-chicken coccidiosis Chinese medicine oral liquid.
Embodiment 2
Get 29 kilograms of Herba Artemisiae Annuaes, 31 kilograms of Radix Dichroaes, 20.5 kilograms of the Radix Pulsatillaes, 19.5 kilograms of the Radixs Astragali clean, cut into slices, grind, soak 2 hours, decoct three times, collecting decoction, filtration, concentrate, precipitate with ethanol, filtration, process 100 liters of anti-chicken coccidiosis Chinese medicine oral liquid.
Embodiment 3
Get 31 kilograms of Herba Artemisiae Annuaes, 29 kilograms of Radix Dichroaes, 19.5 kilograms of the Radix Pulsatillaes, 20.5 kilograms of the Radixs Astragali clean, cut into slices, grind, soak 2 hours, decoct three times, collecting decoction, filtration, concentrate, precipitate with ethanol, filtration, process 100 liters of anti-chicken coccidiosis Chinese medicine oral liquid.
Claims (2)
1. an anti-chicken coccidiosis Chinese medicine composition is characterized in that being made up of the herbal raw material of following mass parts: Herba Artemisiae Annuae 290-310, Radix Dichroae 290-310, Radix Pulsatillae 195-205, Radix Astragali 195-205.
2. anti-chicken coccidiosis Chinese medicine composition according to claim 1 is characterized in that the mass parts of each raw material in the anti-chicken coccidiosis Chinese medicine composition is: Herba Artemisiae Annuae 300, Radix Dichroae 300, the Radix Pulsatillae 200, the Radix Astragali 200.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417654A (en) * | 2013-08-12 | 2013-12-04 | 河南惠通天下生物工程有限公司 | Traditional Chinese medicine composition for preventing and controlling poultry coccidiosis and preparation method of same |
| CN104288248A (en) * | 2014-10-13 | 2015-01-21 | 天津瑞贝特科技发展有限公司 | Traditional Chinese veterinary drug oral liquid for treating chicken coccidiosis and preparation method of oral liquid |
| CN104547898A (en) * | 2014-12-16 | 2015-04-29 | 北京农学院 | Formula of eimeria tenella disease resistant traditional Chinese medicine with fresh bamboo juice as main ingredient |
| CN104644803A (en) * | 2015-01-16 | 2015-05-27 | 沈阳伟嘉牧业技术有限公司 | Preparation method of poultry anticoccidia traditional Chinese medicine oral liquid |
| CN105168331A (en) * | 2015-09-02 | 2015-12-23 | 东北农业大学 | Compound traditional Chinese medicine for preventing and treating coxey and preparation method thereof |
| CN105582199A (en) * | 2016-02-04 | 2016-05-18 | 王树青 | Pharmaceutical composition for treating animal babesiasis |
| CN105663604A (en) * | 2014-11-19 | 2016-06-15 | 天津嘉瑞生物科技有限公司 | Traditional Chinese medicinal composition for treating chicken coccidiosis and preparation method of traditional Chinese medicinal composition |
| CN108066430A (en) * | 2018-01-11 | 2018-05-25 | 郑州福源动物药业有限公司 | A kind of sweet wormwood Changshan effervescence granular for animals and preparation method thereof |
| CN108403796A (en) * | 2018-06-05 | 2018-08-17 | 芮城县维尔富兽药有限公司 | A kind of anti-chicken coccidiasis traditional Chinese medicine oral liquid and preparation method thereof |
| CN108785399A (en) * | 2018-07-27 | 2018-11-13 | 洛阳瑞华动物保健品有限公司 | The Chinese and western medicinal composition and preparation method thereof that one breeder coccidiosis, hemostasis are enriched blood |
Citations (1)
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| CN101040924A (en) * | 2007-04-27 | 2007-09-26 | 天津生机集团有限公司 | Chinese traditional medicine for treating fowl coccidiosis and the preparing method thereof |
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2012
- 2012-08-08 CN CN2012102799058A patent/CN102755399A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101040924A (en) * | 2007-04-27 | 2007-09-26 | 天津生机集团有限公司 | Chinese traditional medicine for treating fowl coccidiosis and the preparing method thereof |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417654B (en) * | 2013-08-12 | 2016-02-10 | 河南惠通天下生物工程有限公司 | A kind ofly prevent and treat Chinese medicine composition of Avian Coccidia disease and preparation method thereof |
| CN103417654A (en) * | 2013-08-12 | 2013-12-04 | 河南惠通天下生物工程有限公司 | Traditional Chinese medicine composition for preventing and controlling poultry coccidiosis and preparation method of same |
| CN104288248A (en) * | 2014-10-13 | 2015-01-21 | 天津瑞贝特科技发展有限公司 | Traditional Chinese veterinary drug oral liquid for treating chicken coccidiosis and preparation method of oral liquid |
| CN104288248B (en) * | 2014-10-13 | 2018-04-27 | 天津赫莱恩特生物科技有限公司 | Treat Traditional Chinese veterinary medicine oral solution of chicken coccidiasis and preparation method thereof |
| CN105663604A (en) * | 2014-11-19 | 2016-06-15 | 天津嘉瑞生物科技有限公司 | Traditional Chinese medicinal composition for treating chicken coccidiosis and preparation method of traditional Chinese medicinal composition |
| CN104547898A (en) * | 2014-12-16 | 2015-04-29 | 北京农学院 | Formula of eimeria tenella disease resistant traditional Chinese medicine with fresh bamboo juice as main ingredient |
| CN104644803A (en) * | 2015-01-16 | 2015-05-27 | 沈阳伟嘉牧业技术有限公司 | Preparation method of poultry anticoccidia traditional Chinese medicine oral liquid |
| CN105168331B (en) * | 2015-09-02 | 2019-12-20 | 东北农业大学 | Compound traditional Chinese medicine for preventing and treating chicken coccidiosis and preparation method thereof |
| CN105168331A (en) * | 2015-09-02 | 2015-12-23 | 东北农业大学 | Compound traditional Chinese medicine for preventing and treating coxey and preparation method thereof |
| CN105582199A (en) * | 2016-02-04 | 2016-05-18 | 王树青 | Pharmaceutical composition for treating animal babesiasis |
| CN108066430A (en) * | 2018-01-11 | 2018-05-25 | 郑州福源动物药业有限公司 | A kind of sweet wormwood Changshan effervescence granular for animals and preparation method thereof |
| CN108403796A (en) * | 2018-06-05 | 2018-08-17 | 芮城县维尔富兽药有限公司 | A kind of anti-chicken coccidiasis traditional Chinese medicine oral liquid and preparation method thereof |
| CN108785399A (en) * | 2018-07-27 | 2018-11-13 | 洛阳瑞华动物保健品有限公司 | The Chinese and western medicinal composition and preparation method thereof that one breeder coccidiosis, hemostasis are enriched blood |
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Application publication date: 20121031 |