CN104644803A - Preparation method of poultry anticoccidia traditional Chinese medicine oral liquid - Google Patents
Preparation method of poultry anticoccidia traditional Chinese medicine oral liquid Download PDFInfo
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- CN104644803A CN104644803A CN201510024186.9A CN201510024186A CN104644803A CN 104644803 A CN104644803 A CN 104644803A CN 201510024186 A CN201510024186 A CN 201510024186A CN 104644803 A CN104644803 A CN 104644803A
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Abstract
The invention relates to a poultry anticoccidia traditional Chinese medicine oral liquid. The oral liquid is mainly prepared from the following four traditional Chinese medicines: hyperforin perforatum, purslane, sanguisorba officinalis and astragalus membranaceus at a certain weight ratio. Purified water is added to hyperforin perforatum, purslane, sanguisorba officinalis, astragalus membranaceus, a surfactant, an antioxidant and a preservative. Effective extraction of the hyperforin perforatum has obvious anticoccidia activity; the sanguisorba officinalis has hemostatic effects; the purslane is capable of improving the survival rate of chicks, and has the efficacies of detoxifying and clearing heat; and the astragalus membranaceus has the effect of enhancing the immunity of animal organism. The oral liquid is prepared by the following steps: independently extracting the hyperforin perforatum according to the ratio, and filtering; respectively decocting the purslane, the sanguisorba officinalis and the astragalus membranaceus, merging filtrate, concentrating, carrying out ethanol extraction, standing, and filtering to obtain filtrate B; and mixing filtrate A with the filtrate B, applying the surfactant, the antioxidant and the preservative, stirring evenly, filtering, sterilizing to form an oral liquid preparation. The preparation is safe, effective, low in toxic and side effects and free of drug resistance.
Description
Technical field
What the present invention relates to is the preparation method of a kind of fowl Chinese medicine oral liquid in field of veterinary
Background technology
Through Patent documents of interest retrieval, not yet retrieve the preparation method of the anticoccidial identical with the present invention at present.
Coccidiosis is a kind of acute popular protozoacide, ubiquity, hazardness is very large, carry out huge economic loss to cultivation industrial belt, often occur in the chickling of 15-50 age in days, after coccidium infection chickling, intestinal mucosal injury, hemorrhage, M & M is very high, mortality rate can reach more than 80%, at present, application coccidiostats a large amount of for a long time on market, toxicity is large, produce cross resistance, cause pollution environmentally simultaneously, therefore according to the situation in aquaculture market, develop a kind of novel, coccidiostat is extremely urgent safely and effectively, Traditional Chinese Medicine Anti coccidiosis is a kind of trend of clinical practice development, various Chinese herbal medicine can use medicine to play respective treatment function through reasonable formula and science collocation, also mutual coordinative role between each medicine can be made, make Chinese herbal medicine jointly to body generation effect, Chinese herbal medicine not only can disease therapy, and can be again body strengthening vital QI to eliminate pathogenic factors, improve himself resistance, thus carry out entirety conditioning, drug resistance can not be produced, these advantages are that Western medicine can not be compared.But due to the solubility problem of Chinese medicine; hamper the application of Chinese medicine on veterinary clinic always; during the present invention utilizes, the effective elements of the medicine has the effect of safe and effective anticoccidial; application surface activating agent increases its dissolubility simultaneously; develop a kind of Chinese medicine oral liquid; automatically drinking-water system can be applied to; conveniently use in large-scale plant; simple to operation; meet needed for market; meet needed for user, be conducive to promoting the development of animal husbandry and the protection of environment, be conducive to the sound development of the mankind.
The content of invention
One of the object of the invention is to provide a kind of effective Chinese medicine coccidiostat, especially for the method for preparation of drug for the treatment of coccidiosis of domestic fowls.
Two of the object of the invention provides preparation method and the purposes of this drug regimen.
Three of the object of the invention provides a kind of Anticoccidiosis pharmaceutical composition, it is characterized in that: it is the preparation be prepared from by the ingredient of following weight proportioning: Herba Hyperici perforati 15-20g, Herba Portulacae 10-15g, Radix Sanguisorbae 10-15g, Radix Astragali 10-15g, surfactant 5-15g, antioxidant 0.1-2.5g, antiseptic 0.2-2.5g, purified water adds to 1000ml.
Concrete implementation method, the weight proportion of said medicine composition is as follows: Herba Hyperici perforati 15g, Herba Portulacae 10g, Radix Sanguisorbae 12g, Radix Astragali 12g, tween 80 10g, sodium sulfite 1g, ethanedioic acid tetraacethyl disodium EDTA-2Na2g, sodium benzoate 5g.
(1) pulverize according to each medicine material of above-mentioned Herba Hyperici perforati, Herba Portulacae, Radix Sanguisorbae, the Radix Astragali, sieve.
(2), after the Herba Hyperici perforati after pulverizing takes above-mentioned grams, 80% alcohol reflux 2 hours, filters, gets filtrate as filtrate A.
(3) 8,6,6 times of soak by water three times used respectively by the Herba Portulacae after pulverizing, Radix Sanguisorbae, the Radix Astragali, often kind of medicine all decocts 1 hour at every turn, merging filtrate after filtering, being concentrated into density is about 1.2, adding ethanol makes determining alcohol reach 80%, hold over night, gets supernatant, is liquor B after filtration.
(4) A liquid cooling is but after less than 40 degree, and water dissolution sodium sulfite 1g, EDTA-2Na 2g, the sodium benzoate 5g of application 50ml, add in A liquid, stir for subsequent use.
(5) get Tween 80, heat 50 degree, get liquor B, add in the tween of preheating, constantly stir, after clarification cooling, B liquid mixes with A liquid, stirs, and ethanolamine regulates pH value to be 5-7, and purified water adds to 1000ml.
(6) filter, sterilizing 100 degree 30 minutes.
Four said preparations of the object of the invention are oral liquid, can apply plant, and automatic water-drinking is applied, easy to use, compared with its Western medicine, concentrate and drink, there is the restriction of time, easily cause the reduction of drug effect, the advantage of said preparation can freely be drunk effectively, safety, low toxicity.
Clinical excess syndrome:
In order to show the prevention effect of the present invention to coccidiosis, application said preparation has commercially done the clinical effectiveness test of relevant anticoccidial, prevention Eimeria species test clinical trial.Because southern climates is hot, moist, coccidiosis sickness rate is higher, therefore selects to have carried out clinical excess syndrome in southern market.
Clinical excess syndrome one, Tongling, Anhui Province raiser 50,000 chickens, wherein AA broiler chicken 22 age in days, 3000 chickens have carried out clinical excess syndrome.Wherein 1000 chickens are as positive controls, give 0.2% diclazuril+2.5% Maduramicin ammonium salt solution, not containing any coccidiostat in feedstuff, and drinking public water supply.This hen house mass-sends disease entirely, and clinical symptoms is lethargy, drowsiness, by Mao Songluan, close order drop-head, slow-wittedly vertically hangs wing, and dysentery of having blood in stool, perianal feathers because manure contamination are adhered, and visual mucosa, hat, whisker are all pale.Other 2000 chickens are applied this oral preparation of Chinese traditional medicinal 500ml/ bottle and are watered 500L, drink 7 days continuously, freely drink.
Result: this oral preparation of Chinese traditional medicinal group the 4th day over the course for the treatment of, hemafecia does not have, the 7th day, and chicken group state recovers normal substantially; Positive controls four days hemafecias are alleviated to some extent, but should have dysentery symptom, and chicken also beats listless state.Result shows: this Chinese medicine preparation has good effect in anticoccidial, and therapeutic effect is better compared with diclazuril+Maduramycin Ammonium.
, there is full group's coccidiosis, 30 ages in days, poor appetite in clinical excess syndrome two: a certain raiser of Qingyang, anhui, become thin, feather is fluffy, dysentery, occurs the feces of Fructus Lycopersici esculenti sample, the course of disease is 2 weeks, dead about 50%, and 2000 broiler, as experiment grouping, one group 1000, positive controls, drinks 0.05% sulfadimethoxine, is mixed in drinking-water, be used in conjunction 6 days, another group is 1000, this oral preparation of Chinese traditional medicinal, drinking-water 500ml/ bottle is watered 500L, automatic water-drinking, continuous application 7 days.
Result: apply this Chinese medicine preparation chicken, the 3rd day, Fructus Lycopersici esculenti feces reduced, the 5th day, and basic feces recovers normal, the 7th day, and chicken group appetite increases, and recovered normal, mortality rate drops to 2%.Positive controls, symptom alleviates, and the more weak chicken group of chicken colony matter occurs death, and mortality rate is reduced to 15%.Result shows that said preparation not only has good therapeutic effect for coccidiosis, has good protective effect compared with other drug for the chicken group that body constitution is more weak.
Namely on the ground clinical excess syndrome three: Guangxi weather is rainy, with the humid air, hen house humidity is relatively high, and chicken group mostly is to raise scattered and supports, and therefore coccidiosis is often broken out in this area, draw hemafecia severe, and rate is high repeatedly, not easily cures.According to this situation, use in area coccidiosis medicine can only the symptom of respite coccidiosis, can not coccidiosis be killed.The a certain raiser in Guangxi 50,000 broiler chicken, 15 ages in days, two hen houses are clinical excess syndrome, and one 3000 is positive controls, the toltrazuril solution of application 2.5%, 100ml is watered 100L, and every day concentrates and drinks 1 hour, drinks 3 days continuously, one 3000 is this extract oral liquid formulation group, 500ml is watered 500L, freely drinks water, and drinks 7 days continuously.
Result: Toltrazuril positive controls second day, symptom alleviates, and reduces hemafecia fast, improves clinical effectiveness, but recurrence after a week.Apply this Chinese medicine preparation group, within the 4th day, symptom alleviates, and continuous application is after seven days, and coccidiosis is effectively treated, and no longer recurs, and improves the resistance against diseases of chicken group, and the environment in purification hen house, can effectively eradicate coccidiosis ovum, not in continuation outburst.
Experiment brief summary: by above clinical excess syndrome explanation; drink this oral preparation of Chinese traditional medicinal; at treatment coccidiosis, there is significant therapeutic effect; the secondary infection caused when breaking out coccidiosis can be controlled simultaneously; control chicken group is while infection coccidiosis; secondary escherichia coli; the infection of the other diseases such as virosis; can be good at the generation controlling disease, strengthen the resistance against diseases of chicken, improve the protective rate of weak young bird; coccidiosis can be killed thoroughly; environment purification, improves the onset state of hen house cluster, no longer continues outburst coccidiosis.
The prescription screening test of medicine:
1. experimental animal:
To just go out AA broiler chicken 1 Japanese instar chickling 2000 of shell, and raise to 14 ages in days under the environment of strict sterilization after buying back, feed and do not add the complete feed of anticoccidial drug.Checked before on-test and confirm that non-ball worm infects.Raise to 15 ages in days for subsequent use under non-ball worm environment.
2. for examination coccidian oocyst:
Tender, the heap-type that Agricultural University Of Shenyang parasite laboratory is preserved and the strain of Eimeria maxima mixing worm, through the breeding of chicken body, rejuvenation before experiment starts.
3. test grouping and process:
15 ages in days divide 8 groups at random for examination chicken, and often organize 200, weigh one by one, except the 1st group, all the other respectively organize every chicken peroral infection mixing Sporulated coccidian oocyst 1.8*10
5individual, in drinking-water, each medicine prescription was added respectively the same day in infection, 8th group adds coccidia powder, feeds, feed continuously to specifications in feedstuff, until off-test, observe the body condition of chicken and the feces of 5-7 days every day after infecting, within the 8th day, kill by only weighing, cuing open after infecting, carry out caecum lesion and score, collect each group chicken manure, count the output of each group of ovum gallinaceum capsule.
4. the index investigated:
Body weight increase rate, lesion score value, relatively egg capsule output (ROP), egg capsule value, anticoccidial index (ACI), survival rate 5 indexs judge.
(1) pathological changes value: every day observation of symptoms and the mark of hemafecia comprise spirit, hair color, appetite and feces etc.After infecting, every day observes and often organizes 24h defecate, and after medication, last day weighs, and cuts open and kills, and carries out cecal lesion score according to the method for Johnson J etc., and often organize average lesion and score, pathological changes mark * 10 is pathological changes value.
(2) relative egg capsule output (ROP), egg capsule value: collect and often organize chicken manure, counting often organizes the quantity of ovum gallinaceum capsule.
Relative egg capsule output (ROP)=(infection medication group egg sac number/infect not medication egg sac number) * 100%;
(3) anticoccidial index (ACI)=(body weight increase rate+survival rate) * 100-(pathological changes value+egg capsule value).
Being Effective Anti coccidiosis as ACI > 180, is middle effect anticoccidial when coccidiosis Index A CI is 160-180; It is poor efficiency anticoccidial when coccidiosis Index A CI is 120-160; When coccidiosis Index A CI < 120 is invalid anticoccidial.
(4) body weight increase rate=(medication group or infect the rate of body weight gain of the rate of body weight gain of not medication group/do not infect not medication group) * 100%:
(5) survival rate=(survival chicken number/test chicken sum) * 100%.
5. test administration process grouping situation
6. experimental result is as follows:
Test result analysis: after artificial challenge, the 2nd group (infection+not administration group) and the 4th group (infection+Herba Portulacae+Radix Sanguisorbae+Radix Astragali), test the 3rd day, chicken group beats listless, occurs that chicken group appetite declines; 5th day, there is hemafecia.5th group and the 7th group does not have hemafecia, and slight hemafecia appears in the 3rd group, 6 groups chicken groups, illustrates that the 5th group can be suppressed coccidiosis in body fast with the 7th group profile, suppresses the generation of hemafecia simultaneously.Cut open the caecum of inspection, the 2nd group, caecum is hemorrhage, the coccidian oocyst that intestinal is a large amount of, and the 3rd group has a small amount of coccidian oocyst with the 6th group, have slight bleeding.1st group is not any change, without hemorrhage, non-ball worm ovum with the 5th group of intestinal; 7 groups of Chinese medicine preparation groups, caecum intestinal non-ball worm ovum, but intestinal mucosa has partial injury, has indigested feedstuff in feces.5th group of best results is described, this Chinese medicine preparation energy anticoccidial, and suppresses hemorrhage.
From the Gain weight of body weight, 5th group compared with the 1st group of blank group, difference is not remarkable, and explanation can suppress coccidiosis, does not affect the appetite of chicken group, compared with the 2nd group of infected group, difference is extremely remarkable, and improve the effect of body weight, the 3rd group, the 6th group, the 7th group compared with the 2nd group of infected group, significant difference, gaining effect.4th group (infection+Herba Portulacae+Radix Sanguisorbae+Radix Astragali), compared with infected group, body weight is close, and difference is not remarkable, and reason is the generation owing to well can not control coccidiosis; From the situation of body weight, the 5th group of best results can anticoccidial, does not affect the appetite of chicken group.
From survival rate, 5th group compared with blank group, difference is not remarkable, difference is extremely remarkable compared with the 2nd group (infecting+not administration group), 3rd group, 6 groups and 7 groups of significant differences compared with the 2nd group (infecting+not administration group), the 3rd group is not remarkable with the 2nd group, best by showing the survival rate of the 5th group of this Chinese medicine preparation group above, effectively can control coccidiosis, the survival rate of chicken group can be improved simultaneously.
From the effect of comprehensive anticoccidial, by anticoccidial index (ACI), the 5th group of this Chinese medicine preparation group > 180 is efficient coccidiostat, 3rd group, 6 groups, 7 groups anticoccidial indexes are between 160-180, are middle effect coccidiostat.4th group is poor efficiency coccidiostat.
In sum, shown by the screening of test, the 5th group of oral preparation of Chinese traditional medicinal group best results, can effective anticoccidial, can improve the survival rate of chicken group, anticoccidial index is the highest, is efficient coccidiostat.
Claims (3)
1. the fowl preparation method of anticoccidial Chinese medicine oral liquid, it is characterized in that according to following weight ratio: Herba Hyperici perforati 15-20g, Herba Portulacae 10-15g, Radix Sanguisorbae 10-15g, Radix Astragali 10-15g, surfactant 5-15g, antioxidant 0.1-2.5g, antiseptic 0.2-2.5g, purified water adds to 1000g.
2. a kind of fowl according to claim 1 preparation method of anticoccidial oral preparation of Chinese traditional medicinal: it is characterized in that processing as follows:
(1) take Herba Hyperici perforati, add 80% ethanol 100ml, reflux, extract, 2 hours, filter, getting filtrate, to be A liquid for subsequent use.
(2) take Herba Portulacae, Radix Sanguisorbae, the Radix Astragali three kinds of Chinese medicinal materials, use 8,6,6 times of soak by water three times respectively, often kind of medical material decocts 1 hour, merging filtrate at every turn, and being concentrated into density is about 1.2, adding ethanol makes determining alcohol reach 80%, and B liquid is filtered and obtained to hold over night.
(3) after A liquid cooling but, get appropriate water and dissolve antioxidant and antiseptic respectively, add in A, stir, A and B liquid mixes, and adds ethanolamine, and adjustment pH value is 5-7, is settled to 1000ml with water.
3. an anticoccidial extract oral liquid formulation, is characterized in that: it is the coccidiosis being used for the treatment of fowl.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116211933A (en) * | 2023-04-06 | 2023-06-06 | 玉林师范学院 | Anticoccidial traditional Chinese medicine composition and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116211933A (en) * | 2023-04-06 | 2023-06-06 | 玉林师范学院 | Anticoccidial traditional Chinese medicine composition and application thereof |
| CN116211933B (en) * | 2023-04-06 | 2024-03-29 | 玉林师范学院 | Anticoccidial traditional Chinese medicine composition and application thereof |
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Application publication date: 20150527 |