CN105616808A - Traditional Chinese veterinary drug with effects of stomach invigorating and deworming, and preparation method thereof - Google Patents

Abstract

The present invention relates to a traditional Chinese veterinary drug with effects of stomach invigorating and deworming, and a preparation method thereof, wherein the traditional Chinese veterinary drug is prepared from the following raw materials by weight: 15-50 parts of hawthorn, 15-40 parts of semen raphani, 15-40 parts of medicated leaven, 10-30 parts of betel nut, 5-25 parts of quisqualis indica, 10-30 parts of torreya grandis, and 10-30 parts of dryopteris crassirhizoma. The preparation process comprises: weighing raw materials, extracting hawthorn and betel nut by using ethanol, concentrating to obtain an ethanol extraction concentration solution, decocting the residue after the extraction, semen raphani, medicated leaven, quisqualis indica, torreya grandis and dryopteris crassirhizoma by using water, carrying out alcohol precipitation, concentrating to obtain a water decoction concentration solution, combining the two concentration solutions, adjusting the pH value to 5.0-6.0, carrying out alcohol precipitation again, filtering, and adding water and an auxiliary material to the filtrate so as t prepare the traditional Chinese veterinary drug. According to the present invention, through the traditional Chinese veterinary drug prepared through the method, the problems that the traditional Chinese medicine powder is not easily absorbed and the residual chemical drug exists can be solved; and different methods are used for different components, such that the problem of insufficient extraction of arecoline and ursolic acid is solved, and the transfer rates of the active ingredients of the herbs are improved.

Description

A kind of herbal medicine with stomach invigorating function for expelling pests and preparation method thereof

Technical field

The invention belongs to herbal medicine, particularly relate to a kind of herbal medicine with stomach invigorating function for expelling pests and preparation method thereof.

Background technology

Along with the raising of the development of animal husbandry and living standards of the people, people are more and more higher to the prescription of animal food, and its medicine residual, hygienic quality etc. are had requirements at the higher level.

In spring and summer, the time when autumn turns into winter, when Changes in weather, domestic animal eats after frost feedstuff, not only causes gastrointestinal disease, and secondary Other diseases, cause domestic animal mortality. Gastroenteropathy is one of principal element affecting the growth of animal cub, growth and adults health. It addition, the poultry such as cattle, pig are in feeding process, often in contact with ground, feed uncooked feed, forage and green forage, it is common to infect the vermins such as demodicid mite, louse, fly larvae. These parasites absorb nutrition, discharge toxin, make pig jump circle, gnaw foreign body, and growth promoter is obstructed. The infection of cestode and the multiple Enterozoa such as ascarid, ancylostome is also the disease that poultry are most commonly seen, and what it was serious affects normal growth and the health of animal. Poultry are had ill effect by the stomach invigorating anthelmintic of chemosynthesis unavoidably, and are digested and assimilated by body, animal not only can be made to produce drug resistance, also can cause drug residue, impact to the health of meat products and the mankind.

Stomach invigorating anthelmintic herbal medicine common at present, many directly pulverizing by crude drug makes powder, cause its efficiency factor digestibility relatively low, also having some herbal medicines to take traditional decocting method, extraction process is extensive, and step is simple, the extracts active ingredients of different components is inefficient, drug quality is unstable, and both of which causes that dosage strengthens, and causes the waste of medical material.

Therefore, develop a kind of stomach invigorating anthelmintic herbal medicine green, safe and efficient, be technical barrier urgently to be resolved hurrily in current animal husbandry development.

Summary of the invention

It is desirable to provide a kind of herbal medicine with stomach invigorating function for expelling pests and preparation method thereof, solve the residue problem not easily absorbed with chemical medicine of Chinese medicine powder, solve arecoline, ursolic acid extracts insufficient problem, improves the rate of transform of medical material effective ingredient simultaneously.

It is an object of the invention to realize in the following manner:

A kind of herbal medicine with stomach invigorating function for expelling pests, its formula is made up of the raw material of following weight portion: Fructus Crataegi 15��50 parts, Semen Raphani 15��40 parts, Massa Medicata Fermentata 15��40 parts, Semen Arecae 10��30 parts, Fructus Quisqualis 5��25 parts, Semen Torreyae 10��30 parts, Rhizoma Osmundae 10��30 parts.

Described formula is made up of the raw material of following weight portion: Fructus Crataegi 20��30 parts, Semen Raphani 20��30 parts, Massa Medicata Fermentata 20��30 parts, Semen Arecae 10��20 parts, Fructus Quisqualis 5��15 parts, Semen Torreyae 10��20 parts, Rhizoma Osmundae 10��20 parts. Optimization formula is be made up of the raw material of following weight portion: Fructus Crataegi 25 parts, Semen Raphani 25 parts, Massa Medicata Fermentata 25 parts, Semen Arecae 15 parts, Fructus Quisqualis 10 parts, Semen Torreyae 10 parts, Rhizoma Osmundae 10 parts.

The preparation method of the herbal medicine with stomach invigorating function for expelling pests is: Fructus Crataegi, Semen Arecae ethanol extraction, concentration, obtain ethanol extraction concentrated solution, the residue after extraction, Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae decocting, precipitate with ethanol, concentration, obtaining water drug-decocting concentrating liquid, two kinds of concentrated solutions merge, and adjust PH to 5.0-6.0, precipitate with ethanol again, after filtration filtrate add water and auxiliaries form.

Ethanol used by described ethanol extraction is the ethanol of volume ratio 50%-100%, such as the ethanol of 50%, the ethanol of 60%, the ethanol of 70%, the ethanol of 80%, the ethanol of 90%, the ethanol of 95%, it is preferable that ethanol is the ethanol of 80%;

Described ethanol extraction is the ethanol adding 3-10 times amount, extracts 1-4 time, each 1-4h, and described precipitate with ethanol is to add ethanol to make ethanol volume by volume concentration be 50%, and after tune pH, precipitate with ethanol makes ethanol volume by volume concentration be 40-90% again, it is preferable that 75%;

Described decocting liquid is that the residue after Fructus Crataegi, Semen Arecae ethanol extraction, Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae carry out the liquid that decocting in water obtains, and Massa Medicata Fermentata gauze wraps up laggard row decocting in water, and Fructus Quisqualis carries out decocting in water after smashing to pieces;

Described adjustment pH is preferably 5.0, Auto-regulator available hydrogen aqueous solution of sodium oxide, sodium bicarbonate aqueous solution or aqueous sodium carbonate;

Described adjuvant is sodium benzoate or sorbic acid, it is preferred to sodium benzoate.

The preparation method of the described herbal medicine with stomach invigorating function for expelling pests is: Fructus Crataegi, Semen Arecae add 5 times amount volume ratios and be 85 DEG C of reflux, extract, of 80% ethanol 2 times, each 2h, united extraction liquid, filters, and concentration is standby; Residue and Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae add 10 times amount distilled water and decoct 3 times, and before decocting, Massa Medicata Fermentata gauze wraps up, and Fructus Quisqualis is smashed to pieces; Each 1h, merges decoction liquor, filters, concentration, adds ethanol and makes ethanol volume by volume concentration be 50%, and precipitate with ethanol stands, filters, concentration, standby; Merge two kinds of extracting solution, mixing, regulate pH to 5.0, adding ethanol makes ethanol volume by volume concentration be 75%, and precipitate with ethanol stands, supernatant concentrating under reduced pressure, filters, adds the sodium benzoate that mass volume ratio is 0.2%, dissolve, filter, add distilled water and be adjusted to every ml and be equivalent to crude drug 1g, embedding, sterilizing, packaging, to obtain final product.

The preparation method is that and obtained by experiment sieving, screening process is as follows:

Organic acid in Fructus Crataegi is the main pharmacodynamics composition of invigorating the stomach and promoting digestion, the alkaloids such as arecoline are the principle active component of anthelmintic, these functional factors can well be dissolved in ethanol, therefore adopts ethanol extraction both can improve extraction yield, can reduce again a large amount of impurity that water extraction brings. Alcohol extracting method adopts the preferred optimum extraction process of orthogonal experiment, according to preliminary experiment, respectively takes 3 levels investigate affecting four bigger factors in technique, with organic acid content, total alkaloid content and yield of extract for inspection target. Material elements level arranges such as table 1. Select orthogonal array L9(34) arrange test, result is in Table 2.

Table 1 factor level table

Table 2 orthogonal experiment plan takes into account result

The maximum of comprehensive grading=(maximum of organic acid content/organic acid content) �� 40+(total alkaloid content/total alkaloid content) maximum of �� 40+(yield of extract/yield of extract) �� 20

Intuitive analysis is carried out it can be seen that experimental result affected C by the extreme difference value (R) of relatively each factor > A > D > B; The results of analysis of variance shows, the significance of experimental result is affected relatively big by C and A factor, and the impact of experimental result has also been reached the significance level on statistical significance by B and D. Can be seen that from orthogonal experiments (comprehensive grading), experiment seven be preferred plan, but comprehensive extreme difference and the results of analysis of variance and actual production situation, selection A3B2C2D3 is the most rational production Technology parameter, namely 5 times amount 80% alcohol reflux is added 2 times, each 2h.

Water proposes some processes research, Semen Arecae, Fructus Crataegi alcohol extraction residue add Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae adopt traditional water carry decocting method, with extractum recovery rate for inspection target, solid-to-liquid ratio, decocting time, decoction number of times being carried out experiment investigation, extraction factor water-glass is in Table 3.

Preferably go out optimum extraction process for adding 10 times amount water, decoct 3 times, each 1h. Decocting and concentrating liquid adds ethanol makes alcohol content be 50%, and precipitate with ethanol stands 24h, press filtration.

The impact on prepared Traditional Chinese veterinary medicine oral solution color and active constituent content of the different pH value, from table 4, increase with pH value, the content of total alkaloids declines, pH value be 4.0 extracting solution clarity slightly worse, pH is being a bit darkish in color of the extracting solution of 7.5, considers, and the pH regulator of oral liquid is 5.0��6.0 by this test and Selection.

The pH value comparative test result that table 4 is different

PH value	3.0	4.0	5.0	6.0	7.0	7.5
							Face shaping	Muddy	Slightly muddy	Clarification	Clarification	Clarification	Darker in color
Total alkaloid content (mg/mL)	0.362	0.353	0.320	0.314	0.303	0.282

The different clarification dosage impacts on prepared Traditional Chinese veterinary medicine oral solution clarity, from table 5 binding tests it can be seen that oral liquid clarification situation in 48h changes with the addition difference of clarifier, precipitate viscosity when ethanol content is 55% big, not easily filtering, the oral liquid clarity made is poor; Alcohol precipitation concentration be 65% oral liquid have a little visible thread precipitation, alcohol precipitation concentration is the clarification of 75%, 85%. So finally adopt alcohol deposition method to be purified, and the alcohol content with 75% is best.

The comparative result of table 5 different clarification dosage oral disposition liquid clarifying effect

Alcohol precipitation concentration (%)	55	65	75	85
					Clarifying effect	++	+	?	?

Note: clarification-relatively clarification+micro-turbid ++

Preservative the selection result is in Table 6. Result shows: the antiseptic effect of sodium benzoate and sorbic acid relatively benzoic acid is good, but the price of sorbic acid relatively sodium benzoate is expensive, therefore oral liquid selects sodium benzoate to be preservative, and its consumption is 0.2%.

Table 6 preservative comparative test result

Preservative kind	Benzoic acid	Sodium benzoate	Sorbic acid
				Preservative consumption	0.2%	0.2%	0.2%
Face shaping	Muddiness after being long placed in	It is long placed in rear brown-red solution	It is long placed in brown-red solution

Table 7 Semen Arecae Different Extraction Method alkaloid

Extracting method	Alkaloid
		Water extraction	0.113%
Dilute hydrochloric acid extraction method	0.222%
		80% ethanol extraction method	0.315%

Table 7 is for making differently to extract alkaloidal content results in Semen Arecae, as can be seen from the table, 80% ethanol extraction alkaloid is nearly three times of tradition water extraction, and pharmacopoeial requirements Fructus Crataegi medical material wants thin layer to differentiate ursolic acid, Fructus Crataegi water carries its ursolic acid thin layer chromatography and identifies that speckle is inconspicuous, and alcohol extracting method result is clearly.

Summary research can obtain, and adopts new preparation method, can be effectively improved the medical material effective ingredient rate of transform and each result all can conformance with standard.

Medical material used by the present invention all meets the pertinent regulations under two items of " Chinese veterinary pharmacopoeia " version in 2010.

Fructus Crataegi appetite-stimulating indigestion-relieving in Traditional Chinese medicine composition formula of the present invention, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, circulation of qi promoting of reducing phlegm, cure mainly dyspeptic abdominal flatulence, dyspepsia, prolonged lochia, antibacterial etc.; Semen Raphani helps digestion de-swelling, lowering the adverse-rising QI to resolve phlegm, cures mainly stagnation of QI due to dyspepsia, distension and fullness in the abdomen etc.; Massa Medicata Fermentata is insufficiency of the spleen not to be changed, promoting digestion and removing stagnation, cures mainly the stomachache because insufficiency of the spleen dyspepsia causes, diarrhoea, inappetence, abdominal part is vexed swollen; Semen Arecae anthelmintic, removing food stagnancy, circulation of qi promoting, diuretic, cure mainly taeniasis, ascariasis, fasciolopsiasis buski, abdominal pain due to worm stagnation, the impaction of rumen, dyspeptic abdominal distention, constipation edema; Fructus Quisqualis anthelmintic, removing food stagnancy, spleen invigorating, cure mainly ascariasis, taeniasis, enterobiasis, trichomoniasis; Semen Torreyae parasite killing, removing food stagnancy, moisturize, cure mainly intestinal parasitical diseases, dryness of the intestine constipation etc.; Rhizoma Osmundae heat-clearing and toxic substances removing, parasite killing stop blooding, and are mainly used in pestilence, macule, haematemesis, epistaxis, discharging fresh blood stool, dysentery, metrorrhagia, leukorrhagia. All medicines share the merit that can strengthen promoting digestion and removing stagnation, strengthen anthelminthic effect, removing stagnancy of indigested food and making QI downward, the wide intestinal of appetizing, anthelmintic, stomach invigorating two effect unification on the basis of stomach invigorating. Cure mainly that getting ill from overeating of poultry be stagnant, dyspepsia or the dyspepsia that causes because of parasite or other diseases, feed intake reduces. Internal coccidiosis and cestode, nematicide, trematodiasis had good inhibiting effect.

Different Chinese medicinal components are adopted different extracting method by the present invention, further optimization through pH regulator, take full advantage of various effective ingredient, technological process is controlled through science screening, the medicine stability prepared is good, stomach invigorating anthelminthic effect is good, cure rate is high, it it is stomach invigorating anthelmintic green, safe and efficient, this Chinese veterinary medicinal composition has feature natural, free of contamination, and have have no drug resistance, without hazard residue, without obvious toxic-side effects, non-harmful feature, be the stomach invigorating anthelmintic herbal medicine of green organic.

Detailed description of the invention

Embodiment 1

A kind of herbal medicine with stomach invigorating function for expelling pests, is made up of the raw material of following weight portion: Fructus Crataegi 15��50 parts, Semen Raphani 15��40 parts, Massa Medicata Fermentata 15��40 parts, Semen Arecae 10��30 parts, Fructus Quisqualis 5��25 parts, Semen Torreyae 10��30 parts, Rhizoma Osmundae 10��30 parts.

Its preparation method comprises the following steps: weigh Chinese crude drug by formula, Fructus Crataegi, Semen Arecae ethanol extraction, concentration, obtain ethanol extraction concentrated solution, residue after extraction, Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae decocting, precipitate with ethanol, concentration, obtain water drug-decocting concentrating liquid, two kinds of concentrated solutions merge, adjust pH to 5.0-6.0, again precipitate with ethanol, after filtration filtrate add water and auxiliaries form.

Embodiment 2

A kind of herbal medicine with stomach invigorating function for expelling pests, is made up of the raw material of following weight portion: Fructus Crataegi 20��30 parts, Semen Raphani 20��30 parts, Massa Medicata Fermentata 20��30 parts, Semen Arecae 10��20 parts, Fructus Quisqualis 5��15 parts, Semen Torreyae 10��20 parts, Rhizoma Osmundae 10��20 parts.

Its preparation method comprises the following steps: weigh Chinese crude drug by formula, Fructus Crataegi, Semen Arecae add the ethanol of volume ratio 50%-100%, solid-to-liquid ratio 3-10, extract 1-4 time, each 1-4h, obtain ethanol extraction concentrated solution, residue after extraction, Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae decocting, precipitate with ethanol, concentration, obtain water drug-decocting concentrating liquid, two kinds of concentrated solutions merge, and adjust pH to 5.0-6.0, again precipitate with ethanol, add ethanol make ethanol volume by volume concentration be 40-90%, after filtration filtrate add water and auxiliaries form.

Embodiment 3

A kind of herbal medicine with stomach invigorating function for expelling pests, is made up of the raw material of following weight portion: Fructus Crataegi 25 parts, Semen Raphani 25 parts, Massa Medicata Fermentata 25 parts, Semen Arecae 15 parts, Fructus Quisqualis 10 parts, Semen Torreyae 10 parts, Rhizoma Osmundae 10 parts.

Preparing according to the following steps: weigh raw material by formula, Fructus Crataegi, Semen Arecae add 5 times amount volume ratios and are 85 DEG C of reflux, extract, of 80% ethanol 2 times, each 2h, united extraction liquid, filter, and concentration is standby; Residue and Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae add 10 times amount distilled water and decoct 3 times, and before decocting, Massa Medicata Fermentata gauze wraps up, and Fructus Quisqualis is smashed to pieces; Each 1h, merges decoction liquor, filters, concentration, adds ethanol and makes ethanol volume by volume concentration be 50%, and precipitate with ethanol stands, filters, concentration, standby; Merge two kinds of extracting solution, mixing, regulate pH to 5.0 with aqueous sodium carbonate, adding ethanol makes ethanol volume by volume concentration be 75%, and precipitate with ethanol stands, supernatant concentrating under reduced pressure, filters, adds the sodium benzoate that mass volume ratio is 0.2%, dissolve, filter, add distilled water and be adjusted to every ml and be equivalent to crude drug 1g, embedding, sterilizing, packaging, to obtain final product.

Embodiment 4

A kind of herbal medicine with stomach invigorating function for expelling pests, is made up of the raw material of following weight portion: Fructus Crataegi 15 parts, Semen Raphani 40 parts, Massa Medicata Fermentata 30 parts, Semen Arecae 10 parts, Fructus Quisqualis 5 parts, Semen Torreyae 10 parts, Rhizoma Osmundae 30 parts.

Preparing according to the following steps: weigh raw material by formula, Fructus Crataegi, Semen Arecae add 4 times amount volume ratios and are 85 DEG C of reflux, extract, of 60% ethanol 1 time, each 1h, united extraction liquid, filter, and concentration is standby; Residue and Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae add 10 times amount distilled water and decoct 3 times, and before decocting, Massa Medicata Fermentata gauze wraps up, and Fructus Quisqualis is smashed to pieces; Each 1h, merges decoction liquor, filters, concentration, adds ethanol and makes ethanol volume by volume concentration be 50%, and precipitate with ethanol stands, filters, concentration, standby; Merge two kinds of extracting solution, mixing, regulate pH to 5.0 with aqueous sodium carbonate, adding ethanol makes ethanol volume by volume concentration be 50%, and precipitate with ethanol stands, supernatant concentrating under reduced pressure, filters, adds the sodium benzoate that mass volume ratio is 0.2%, dissolve, filter, add distilled water and be adjusted to every ml and be equivalent to crude drug 1g, embedding, sterilizing, packaging, to obtain final product.

Embodiment 5

A kind of herbal medicine with stomach invigorating function for expelling pests, is made up of the raw material of following weight portion: Fructus Crataegi 20 parts, Semen Raphani 15 parts, Massa Medicata Fermentata 15 parts, Semen Arecae 30 parts, Fructus Quisqualis 15 parts, Semen Torreyae 15 parts, Rhizoma Osmundae 10 parts.

Preparing according to the following steps: weigh raw material by formula, Fructus Crataegi, Semen Arecae add 8 times amount volume ratios and are 85 DEG C of reflux, extract, of 60% ethanol 2 times, each 90min, united extraction liquid, filter, and concentration is standby; Residue and Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae add 10 times amount distilled water and decoct 3 times, and before decocting, Massa Medicata Fermentata gauze wraps up, and Fructus Quisqualis is smashed to pieces; Each 1h, merges decoction liquor, filters, concentration, adds ethanol and makes ethanol volume by volume concentration be 50%, and precipitate with ethanol stands, filters, concentration, standby; Merge two kinds of extracting solution, mixing, regulate pH to 5.5 with aqueous sodium carbonate, adding ethanol makes ethanol volume by volume concentration be 60%, and precipitate with ethanol stands, supernatant concentrating under reduced pressure, filters, adds the sodium benzoate that mass volume ratio is 0.2%, dissolve, filter, add distilled water and be adjusted to every ml and be equivalent to crude drug 1g, embedding, sterilizing, packaging, to obtain final product.

Embodiment 6

A kind of herbal medicine with stomach invigorating function for expelling pests, is made up of the raw material of following weight portion: Fructus Crataegi 30 parts, Semen Raphani 20 parts, Massa Medicata Fermentata 40 parts, Semen Arecae 20 parts, Fructus Quisqualis 25 parts, Semen Torreyae 20 parts, Rhizoma Osmundae 15 parts.

Preparing according to the following steps: weigh raw material by formula, Fructus Crataegi, Semen Arecae add 7 times amount volume ratios and are 85 DEG C of reflux, extract, of 60% ethanol 1 time, each 1h, united extraction liquid, filter, and concentration is standby; Residue and Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae add 10 times amount distilled water and decoct 3 times, and before decocting, Massa Medicata Fermentata gauze wraps up, and Fructus Quisqualis is smashed to pieces; Each 1h, merges decoction liquor, filters, concentration, adds ethanol and makes ethanol volume by volume concentration be 50%, and precipitate with ethanol stands, filters, concentration, standby; Merge two kinds of extracting solution, mixing, regulate pH to 5.0 with sodium hydrate aqueous solution, adding ethanol makes ethanol volume by volume concentration be 70%, and precipitate with ethanol stands, supernatant concentrating under reduced pressure, filters, adds the sodium benzoate that mass volume ratio is 0.2%, dissolve, filter, add distilled water and be adjusted to every ml and be equivalent to crude drug 1g, embedding, sterilizing, packaging, to obtain final product.

Embodiment 7

A kind of herbal medicine with stomach invigorating function for expelling pests, is made up of the raw material of following weight portion: Fructus Crataegi 35 parts, Semen Raphani 25 parts, Massa Medicata Fermentata 35 parts, Semen Arecae 25 parts, Fructus Quisqualis 20 parts, Semen Torreyae 25 parts, Rhizoma Osmundae 20 parts.

Preparing according to the following steps: weigh raw material by formula, Fructus Crataegi, Semen Arecae add 9 times amount volume ratios and are 85 DEG C of reflux, extract, of 70% ethanol 2 times, each 100min, united extraction liquid, filter, and concentration is standby; Residue and Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae add 10 times amount distilled water and decoct 3 times, and before decocting, Massa Medicata Fermentata gauze wraps up, and Fructus Quisqualis is smashed to pieces; Each 1h, merges decoction liquor, filters, concentration, adds ethanol and makes ethanol volume by volume concentration be 50%, and precipitate with ethanol stands, filters, concentration, standby; Merge two kinds of extracting solution, mixing, regulate pH to 6.0 with sodium bicarbonate aqueous solution, adding ethanol makes ethanol volume by volume concentration be 40%, and precipitate with ethanol stands, supernatant concentrating under reduced pressure, filters, adds the sodium benzoate that mass volume ratio is 0.2%, dissolve, filter, add distilled water and be adjusted to every ml and be equivalent to crude drug 1g, embedding, sterilizing, packaging, to obtain final product.

Embodiment 8

A kind of herbal medicine with stomach invigorating function for expelling pests, is made up of the raw material of following weight portion: Fructus Crataegi 40 parts, Semen Raphani 35 parts, Massa Medicata Fermentata 18 parts, Semen Arecae 22 parts, Fructus Quisqualis 12 parts, Semen Torreyae 30 parts, Rhizoma Osmundae 18 parts.

Preparing according to the following steps: weigh raw material by formula, Fructus Crataegi, Semen Arecae add 5 times amount volume ratios and are 85 DEG C of reflux, extract, of 70% ethanol 1 time, each 80min, united extraction liquid, filter, and concentration is standby; Residue and Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae add 10 times amount distilled water and decoct 3 times, and before decocting, Massa Medicata Fermentata gauze wraps up, and Fructus Quisqualis is smashed to pieces; Each 1h, merges decoction liquor, filters, concentration, adds ethanol and makes ethanol volume by volume concentration be 60%, and precipitate with ethanol stands, filters, concentration, standby; Merge two kinds of extracting solution, mixing, regulate pH to 5.4 with sodium bicarbonate aqueous solution, adding ethanol makes ethanol volume by volume concentration be 90%, and precipitate with ethanol stands, supernatant concentrating under reduced pressure, filters, adds the sodium benzoate that mass volume ratio is 0.2%, dissolve, filter, add distilled water and be adjusted to every ml and be equivalent to crude drug 1g, embedding, sterilizing, packaging, to obtain final product.

Embodiment 9

A kind of herbal medicine with stomach invigorating function for expelling pests, is made up of the raw material of following weight portion: Fructus Crataegi 45 parts, Semen Raphani 40 parts, Massa Medicata Fermentata 32 parts, Semen Arecae 12 parts, Fructus Quisqualis 22 parts, Semen Torreyae 18 parts, Rhizoma Osmundae 25 parts.

Preparing according to the following steps: weigh raw material by formula, Fructus Crataegi, Semen Arecae add 6 times amount volume ratios and are 85 DEG C of reflux, extract, of 70% ethanol 1 time, each 70min, united extraction liquid, filter, and concentration is standby; Residue and Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae add 10 times amount distilled water and decoct 3 times, and before decocting, Massa Medicata Fermentata gauze wraps up, and Fructus Quisqualis is smashed to pieces; Each 1h, merges decoction liquor, filters, concentration, adds ethanol and makes ethanol volume by volume concentration be 70%, and precipitate with ethanol stands, filters, concentration, standby; Merge two kinds of extracting solution, mixing, regulate pH to 5.8 with sodium hydrate aqueous solution, adding ethanol makes ethanol volume by volume concentration be 90%, and precipitate with ethanol stands, supernatant concentrating under reduced pressure, filters, adds the sodium benzoate that mass volume ratio is 0.2%, dissolve, filter, add distilled water and be adjusted to every ml and be equivalent to crude drug 1g, embedding, sterilizing, packaging, to obtain final product.

Embodiment 10

A kind of herbal medicine with stomach invigorating function for expelling pests, is made up of the raw material of following weight portion: Fructus Crataegi 50 parts, Semen Raphani 30 parts, Massa Medicata Fermentata 20 parts, Semen Arecae 18 parts, Fructus Quisqualis 18 parts, Semen Torreyae 20 parts, Rhizoma Osmundae 22 parts.

Preparing according to the following steps: weigh raw material by formula, Fructus Crataegi, Semen Arecae add 4 times amount volume ratios and are 85 DEG C of reflux, extract, of 80% ethanol 3 times, each 110min, united extraction liquid, filter, and concentration is standby; Residue and Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae add 10 times amount distilled water and decoct 3 times, and before decocting, Massa Medicata Fermentata gauze wraps up, and Fructus Quisqualis is smashed to pieces; Each 1h, merges decoction liquor, filters, concentration, adds ethanol and makes ethanol volume by volume concentration be 80%, and precipitate with ethanol stands, filters, concentration, standby; Merge two kinds of extracting solution, mixing, regulate pH to 5.6 with sodium bicarbonate aqueous solution, adding ethanol makes ethanol volume by volume concentration be 90%, and precipitate with ethanol stands, supernatant concentrating under reduced pressure, filters, adds the sodium benzoate that mass volume ratio is 0.2%, dissolve, filter, add distilled water and be adjusted to every ml and be equivalent to crude drug 1g, embedding, sterilizing, packaging, to obtain final product.

Embodiment 11

A kind of herbal medicine with stomach invigorating function for expelling pests, is made up of the raw material of following weight portion: Fructus Crataegi 30 parts, Semen Raphani 20 parts, Massa Medicata Fermentata 40 parts, Semen Arecae 20 parts, Fructus Quisqualis 25 parts, Semen Torreyae 20 parts, Rhizoma Osmundae 22 parts.

Preparing according to the following steps: weigh raw material by formula, Fructus Crataegi, Semen Arecae add 3 times amount volume ratios and are 85 DEG C of reflux, extract, of 80% ethanol 1 time, each 120min, united extraction liquid, filter, and concentration is standby; Residue and Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae add 10 times amount distilled water and decoct 3 times, and before decocting, Massa Medicata Fermentata gauze wraps up, and Fructus Quisqualis is smashed to pieces; Each 1h, merges decoction liquor, filters, concentration, adds ethanol and makes ethanol volume by volume concentration be 90%, and precipitate with ethanol stands, filters, concentration, standby; Merge two kinds of extracting solution, mixing, regulate pH to 5.2 with sodium bicarbonate aqueous solution, adding ethanol makes ethanol volume by volume concentration be 80%, and precipitate with ethanol stands, supernatant concentrating under reduced pressure, filters, adds the sodium benzoate that mass volume ratio is 0.2%, dissolve, filter, add distilled water and be adjusted to every ml and be equivalent to crude drug 1g, embedding, sterilizing, packaging, to obtain final product.

Embodiment 12

A kind of herbal medicine with stomach invigorating function for expelling pests, is made up of the raw material of following weight portion: Fructus Crataegi 32 parts, Semen Raphani 22 parts, Massa Medicata Fermentata 42 parts, Semen Arecae 10 parts, Fructus Quisqualis 7 parts, Semen Torreyae 28 parts, Rhizoma Osmundae 28 parts.

Preparing according to the following steps: weigh raw material by formula, Fructus Crataegi, Semen Arecae add 10 times amount volume ratios and are 85 DEG C of reflux, extract, of 80% ethanol 2 times, each 60min, united extraction liquid, filter, and concentration is standby; Residue and Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae add 10 times amount distilled water and decoct 3 times, and before decocting, Massa Medicata Fermentata gauze wraps up, and Fructus Quisqualis is smashed to pieces; Each 1h, merges decoction liquor, filters, concentration, adds ethanol and makes ethanol volume by volume concentration be 50%, and precipitate with ethanol stands, filters, concentration, standby; Merge two kinds of extracting solution, mixing, regulate pH to 6.0 with sodium bicarbonate aqueous solution, adding ethanol makes ethanol volume by volume concentration be 75%, and precipitate with ethanol stands, supernatant concentrating under reduced pressure, filters, adds the sodium benzoate that mass volume ratio is 0.2%, dissolve, filter, add distilled water and be adjusted to every ml and be equivalent to crude drug 1g, embedding, sterilizing, packaging, to obtain final product.

For showing the prevention effect of the herbal medicine with stomach invigorating function for expelling pests provided by the invention, carry out drug effect and application attestation test, the beneficial effect of of the present invention medicine has been expanded on further below by way of test example.

Test example 1

Henan plant, replacement gilt 100, before test, faecal egg inspection is the swinery of parasite severe infections. test pig is randomly divided into 5 groups, uses different anthelmintic and dosage. 1st group: fenbendazole powder group (Chengdu Qiankun Animal Drug Industry Co., Ltd., veterinary drug word (2013) 220221189, product specification 5%, lot number 20140206), it is recommended that dosage pig 5��7.5mg/Kg body weight. 2nd group: ivermectin injection group (Guangdong Teng Jun animal pharmaceutical estate company limited, veterinary drug word (2013) 190151126, product rule 5mL:0.05g, lot number 20140317), it is recommended that dosage pig 0.03mL/Kg body weight. 3rd group: digestive powder group (Hai Tian bio tech ltd, Henan, veterinary drug word (2013) 162505134, lot number 20140305. ), it is recommended that consumption pig 30��60g/Kg body weight. 4th group: the embodiment of the present invention 3 prepares medicine, 1.0g/ml). 5th group: blank group, do not feed any medicine. dispensing before and dispensing after 7d, 14d, 28d, 35d saturated saline floatation checks worm's ovum, Mai Kemasiteshi (Mcmaster ' s) method carries out worm's ovum inspection, add up gastrointestinal nematode worm's ovum (larva) number (EPG) in every 1g feces, by only making EPG itemized record, and make Redution of eggs and Negative rate on the egg statistics, to judge anthelminthic effect, computing formula is as follows: Redution of eggs=[before (before test average EPG value after average EPG value-test)/test average EPG value] �� 100%, Negative rate on the egg=(experimental animal turn out cloudy a number/confession examination number of animals) �� 100%

The average EPG value of nematicide worm's ovum (larva) after dispensing and Redution of eggs, refer to table 8. Table 8 result shows, the nematicide slip of the 1st group, the 2nd group, the 3rd group, the 4th group respectively 85.3%, 88.7%, 83.7%, 92.6%, through statistical disposition, the 4th group of therapeutic effect significant difference to pig Intestinal Nematode Infections (P< 0.05), and drug effect duration.

Table 8 different time anthelmintic result

Test pig is turned out cloudy and is counted and negative conversion rate statistics, refers to table 9. Table 9 result shows, the 1st group, the 2nd group, the 3rd group, the 4th group negative conversion rate respectively 75%, 80%, 70%, 100%, through statistical disposition, the 4th group with other test group therapeutic effect significant difference (P < 0.05) to pig Intestinal Nematode Infections.

Table 9 nematicide worm's ovum (larva) negative conversion rate

After dispensing, herbal medicine group Redution of eggs of the present invention is up to 92.6%, illustrates that this medicine is better to the therapeutic effect of pig Intestinal Nematode Infections. The Redution of eggs of fenbendazole group, ivermectin group and compound recipe powder for improving appetite group is all below 90%. The domestic Redution of eggs before and after report treated with medicaments group medication judges Drug resistance, criterion is determined below 90%, this test fenbendazole, ivermectin Redution of eggs after dispensing is 85.3% and 88.7%, lower than 90%, illustrate to exist to a certain extent Drug resistance, because investigation limited amount also needs further investigation.

The test of anthelmintic negative conversion rate shows, herbal medicine of the present invention is notable to pig intestinal nematodes insecticidal effect, and after anthelmintic, experimental animal Negative rate on the egg reaches 100%. In process of the test, herbal medicine of the present invention has certain anthelmintic and appetizing effect, has promoted that the normal growth of test pig is grown, and reduces feedstuff-meat ratio, improves the economic benefit of cultivation.

Test example 2

In December, 2013, pig farm, Henan, morbidity pig is 3��6 monthly age pigletss, and the performance of part affected pig gradual is become thin, anemia, slightly random, matt by hair, grinds one's teeth in sleep, cough at midnight, dyspnea, hurriedly irregular, and often occur together heavy and abrasive cough. When butchering find liver connective tissue proliferation, formed " milk spots liver ", adult divide a word with a hyphen at the end of a line entrance bile duct cause jaundice and colic symptoms. Swinery growth retardation, feed conversion rate declines, it is easy to other bacillary or viral respiratory diseases of secondary, causes swinery sickness rate to rise, and treatment difficulty strengthens. According to clinical symptoms, cut open inspection pathological changes be diagnosed as parasitic infection.

The medicine using the present embodiment 4 preparation gavages morbidity pig with 5mL/Kg, is used in conjunction 7, and from the 3rd day, the state of an illness started to alleviate, and affected pig is breathed cough symptom and alleviated, and finds white nematicide in the feces of discharge. Within 5th day, rising, the ill pig mental status is good, and appetite recovers normal.

Test example 3

In November, 2013, Anhui village Demonstration farm raises boer goat 376, since July, in field, only there is under anemia, jaw edema, has loose bowels for the disease of principal character in more than part 4 monthly age sheep, and field instigator uses Multiple Classes of Antibiotics poor effect, and sheep death increases day by day. Sick sheep has loose bowels repeatedly, and feces becomes medicated porridge sample, often has stench, and with having loose bowels, medicine is failed to respond to any medical treatment, and becomes thin gradually; Visual mucosal pallor, anemia, by hair slightly random, grey black; Edema under part sheep jaw, loss of appetite, the state of an illness is severe exacerbation gradually, myasthenia of limbs, does not rise sleepingly, but still has certain appetite, finally dead because of malignant disease. Pathological anatomy: blood is thin, color is light red; Pericardial effusion, heart is soft; Part pulmonary lobule generation red meat becomes; Liver surface has the downright bad point of white; Gollbladder dilation, inside has yellowish-brown bile. Cud coat of the stomach finds a small amount of pale red polypide; In abomasum, chyme is less, and mucosa is that diffusivity is hemorrhage, has a large amount of polypide in Flos Cannabis sample red and white. Root is by dissecting, in conjunction with the clinical symptoms of sick sheep, it may be determined that parasite is goat morbidity, dead main pathogenic. Drug therapy and urgent prevention, the medicine that whole audience sheep is prepared only according to embodiment 5 gavages with 5mL/Kg body weight, is used in conjunction 7d. Using latter 3 days, sick sheep symptom of having loose bowels alleviates; After using 7d, the state of an illness is substantially achieved control, and sick sheep appetite increases, and spirit is better, it does not have death report.

Test example 4

Certain pig farm Du �� length �� Dasanyuan hybridization piglet 195 (average weight is 21Kg), shows 3 pig lassitudes, loss of appetite at 2 pigsty inland superventions, day by day becomes thin, by hair slightly unrest and with diarrhoea. Also having several pig morbidities in other several pigsties, morbidity pig is grown with each passing day later. Sick pig spirit is depressed, is off one's feed, gradually row become thin, anemia, slightly random, matt by hair, palor, coarse, follow the string, eye conjunctiva is pale. Most in intractable diarrhea, discharge water sample loose stool, taste stench, sometimes with the red blood streak or brown hemafecia. Along with the generation of diarrhoea, thin and weak unable, the dehydration of affected pig, walking is rocked, happiness is lain prostrate, appetite is useless absolutely, is yearningly intended to increase, finally dies of exhaustion.

Cuing open 2 sick dead pig of inspection, major lesions is that caecum is congested, hemorrhage, swelling, has the necrotic lesion of Semen phaseoli radiati size, and colonic pathological change is similar to caecum. Cecal content stench, intestinal mucosa is kermesinus, and mucosa is covered with the polypide of milky fine needle sample, and polypide one section pierces in mucosa, and outside one section of dew, number is a lot of. Taking out several polypides, observe and see polypide one end tubbiness, the other end is elongated. Breast, intraperitoneal have more faint yellow exudate, and mesentery is gelatinous infiltration. Cardiac muscle is soft, light white, and liver, spleen have atrophy in various degree and degeneration, and other organs official is without obvious pathological changes. While the work of colony house disinfecting is carried out in reinforcement feeding and management, this batch of piglet is all carried out anthelmintic, gavages with using dosage 5mL/Kg body weight according to the medicine of embodiment 6 preparation, simultaneously to seriously ill 2 times/d of pig oresol, every each 30��50mL, is used in conjunction 7d. Hereafter, swinery generally spirit takes a turn for the better, and appetite increases, and defecation increases, and original sense is caught pig and recovered normally all gradually, rechecks and have no new cases after 2 weeks.

Test example 5

In early April, 2013,425, this pig farm nursery pig successively sporadicly there occurs that intractable is had loose bowels, poultry is main once by Drug therapys such as norfloxacin, gentamycin, polymyxin and pig genetic engineering interferons all to no effect, and the state of an illness spreads gradually, morbidity 110, dead 16 in 2 weeks, also there is the state of an illness in rear 320 growing and fattening pigs in 1 week, have 90 hairs diseases, 5 death. Affected pig spirit is depressed, and withered inverse random by hair shaft, happiness is lain prostrate, flocked together, and most body temperature are normal, and the slightly rising having is typically in 40.5 DEG C. Loss of appetite or useless absolutely, thirsty, tremble, suffer from diarrhoea, elder generation's ash discharge brown loose stool, feces is water sample afterwards, yellow or Lycoperdon polymorphum Vitt, with fragment of tissue or blood, severe patient dehydration, collapses in the ground, may finally cause death. The most acute person mostly is sudden onset, without obvious clinical symptom i.e. death. Cuing open 9 dying nursery pig of inspection and 4 acute death growing and fattening pigs, pathological changes is mainly manifested in colon and caecum, and intestinal wall is thinning, congested, hemorrhage, downright bad, has exedens focus. Mesenteric adenophyma is big, and in cord-like, tangent plane turns up. Enteral fills canescence paste content, and the whole mesentery from jejunum to rectum of acute death is that diffusivity is hemorrhage, and intestinal contents has a large amount of blood.

Full group, with the drinking-water diseases prevention pig dehydration of fluid infusion salt, health invigorating, reduces loss. The medicine respectively full group's nursery pig, growing and fattening pigs prepared according to embodiment 7 gavages with using dosage 5mL/Kg body weight, is used in conjunction 7d. Additionally, improve feeding environment, keep feedstuff, drinking water hygiene; Pigsty and pig are carried out disinfection, isolation morbidity pig. Adopting said method, the one week treatment state of an illness is controlled, and has no new cases, and sick pig is all cured.

Test example 6

In October, 2013, the large-scale plant in Guangdong, the piglet of 7��11 ages in days is suffered from diarrhoea, and during beginning, difference is soft in the pasty state, along with aggravation feces is aqueous, and gives out the acid smell of corrupt milk sample. Sick pig lethargy, shows weak, dehydration, hypoevolutism, loses weight. Slightly disorderly matt by hair, skin is dimmed, bleach, nonelastic, eye socket sink, and happiness is sleeping, minimizing of sucking the breast. Cuing open inspection visible, major lesions sees jejunum and ileal epithelium necrosis comes off, intestinal villus atrophy, intestinal mucosa has foreign body cover, and intestinal serous coat has ecchymosis, shows as necrotic enteritis. Taking affected pig fecal smear microscopy, microscope is observed and is found polypide, cuts open inspection according to epidemiology, clinical symptoms and pathology and is diagnosed as pig coccidiosis. With the medicine of embodiment 8 preparation, the piglet of all morbidities is gavaged according to using dosage 5mL/Kg body weight, be used in conjunction 7d. The whole audience being strengthened sterilization, prevention effect is quickly, substantially simultaneously. After one week treatment, swinery anthelminthic effect is obvious, and morbidity swine diseases feelings are controlled, and has no morbidity pig.

Test example 7

At the beginning of 2014 3 months, Yulin feed lot feeding black goat 205, just start to find that 5 lambs have frequent cough, sneeze symptom, especially early morning and night are obvious, mostly are paroxysmal cough, normal expectoration mucus agglomerate, sound is had during cough, dyspnea, suffers from discharge purulent secretion in sheep nostril, sometimes in streamline shape nasal mucus. The ill domestic animal initial stage by hair slightly disorderly, watery nasal discharge, sheds tears, and becomes thin gradually, suffers from and raise visual mucosal pallor, in anemia, dewatering symptom. Lamb serious symptom, mortality rate is also high, and 5 the lamb symptoms infected at first are on the rise, finally dead. The sheep that goes newly to die of illness cuts open inspection, and the most significant pathological change is the visible pulmonary atelectasis in various degree of pulmonary and emphysema, and lung surface dragon is ridden, Calx emulsus color, the solid sense touched. Cut lung, bronchus, inside have petechia, full thickness, cloudy mixture, trachea intracavity a large amount of agglomerating polypides as seen, worm's ovum. Cut open inspection and lab testing according to incidence, clinical symptoms, pathology, be diagnosed as Pulmonis caprae seu ovis nematode infections. Prophylactico-therapeutic measures: first sheep heavier for symptom is first isolated, then carry out whole audience anthelmintic, gavage by using dosage 5mL/Kg body weight with the medicine of embodiment 9 preparation, be used in conjunction 7d. After treating 1 week, the lamb exhaustion death that only 1 infection symptoms is heavier, other ill sheep all gradually recover one's health, and appetite is good.

Test example 8

In October, 2013,150 boer goats of Kenli County, Shandong plant, successively 32 occur lethargy, appetite to decline, suffer from diarrhoea, become thin, the disease of the symptom such as lymph and enlargement, in ten days dead 8. This is sick multiple is born in 5��7 monthly age lambs, and sickness rate accounts for 20%. Sheep symptom of growing up is relatively light, and sickness rate is low, and lamb symptom is obvious, and mortality rate is high. Sick sheep is by the withered tarnish of hair shaft, and body weight declines rapidly, and cardinal symptom is that appetite declines, is yearningly intended to increases, dysentery, anemia, lymphadenectasis, becomes thin, sleeping does not rise, spits out white foams, mucosal pallor, sometimes twitches, the nervous symptoms such as turning motion. Before having a sheep dead, opisthotonus occurs, twitch, the symptom such as turn-take, the course of disease 8 days, containing yellow-white nodal plate in feces in sheep hurdle. Cuing open the lamb that dies of illness of inspection, the internal organs such as the heart, lung, liver, kidney are without macroscopic pathological change. Mesenteric lymph node surface is cinerous, long strand swelling, and tangent plane edema liquefies, and intestinal mucosa is hemorrhage, and cutting little enteral open has banding merogenesis polypide, is about l��2m, and width is 1��1.5cm about; Outward appearance is yellow-white, and front have a spherical cephalomere. Cephalomere, through microscopy, above has the sucker of 4 approximate ellipsoidals, according to clinical symptoms, cuts open inspection change and the diagnosis such as epidemic characteristic is goat monesiosis. Morbidity sheep only isolates breeding observing, strengthens nutritional supplementation. Whole audience anthelmintic, uses the medicine of embodiment 10 preparation to gavage by using dosage 5mL/Kg body weight, is used in conjunction 7d. Using latter 3 days, suffer from the sheep mental status and take a turn for the better, after being used in conjunction one week, flock of sheep recover normal, and stomach invigorating anthelmintic anthelminthic effect prepared by the present invention is obvious.

Test example 9

152 body weight market pig at about 30Kg is bought on certain pig farm from other provinces, the mixed group when measure is taked effectively to quarantine in end, through the raising of about 10 days, 7 pig morbidities occur successively, antibiotic, sulfa drugs and glucose, vitamin C etc. is used to treat all without positive effect, to falling ill 35 when seeing and treating patients altogether, dead 8. Affected pig shows as depressed, the inappetence of spirit, happiness drink filthy water, it is unable to walk, happiness is lain prostrate. body temperature up to 39.8 DEG C��40.5 DEG C, most sick pigs be intractable diarrhea, discharge water sample light stool, taste stench, and later stage feces is brownish red with the blood streak, part. The course of disease mostly is chronic process and reaches about 10��15 days, sick pig finally because of dyspnea, dehydration, extreme exhaustion and dead. Main at intestinal, show as caecum and colonic mucosa is congested, hemorrhage, edema, erosion, a large amount of mucus as seen when having a large amount of polypide in intestinal. Intestinal mucosa is pale red, and its surface is covered with milky needle-like polypide, visible polypide after rinsing intestinal mucosa surface feces with clear water. One end pierces intestinal mucosa, and the other end exposes, and polypide front portion is elongated, the short and thick likeness in form in rear portion " horsewhip ". Mesentery is gelatinous infiltration; Cardiac muscle is soft, pale: liver, spleen have atrophy in various degree and degeneration; Breast, intraperitoneal have more faint yellow exudate; Lungs part has petechial hemorrhage, point leaf, lobus cardiacus consolidation. By clinical symptoms, cut open inspection change be diagnosed as Penis et testis sus domestica parasitosis. By 1%��3% compound iodine solution, pig house, apparatus etc. are carried out disinfection, every day 1 time. Keep pig house cleaning dry, so as to the growth of uncomfortable platform worm's ovum. The medicine simultaneously using embodiment 11 preparation gavages by using dosage 5mL/Kg body weight treats, and full group is used in conjunction 7 days. After using when the 2nd day, can be observed have substantial amounts of polypide to discharge in swine excrement, sick pig spirit starts to take a turn for the better, sick pig rehabilitation after 1 week.

Test example 10

In April, 2014,60 2 monthly age piglets are introduced on pig farm, Xushui, Hebei, carry out ground stable breeding. May 10, part pig falls ill, dead 6, sickness rate 50%, case fatality rate 10%. It is depressed that sick pig shows as spirit, breathes and palpitating speed, and appetite declines, different addicted to, become thin, anemia, coarse by hair, malnutrition, indivedual pig general jaundice. There is slight cough caused by pathogenic damp in part pig, and body temperature is increased to 40.5 DEG C, and dyspnea occurs in serious affected pig of falling ill, abrasive cough, thirsty, sialorrhea, have loose bowels, the symptom such as restlessness, extremity dap. Cuing open inspection to die of illness piglet, corpse is become thin, and lung tissue is fine and close, and there is petechia on surface, tracheal strips has a large amount of cystose mucus with blood, and liver is hemorrhage, degeneration, has substantial amounts of " cloud and mist speckle ", has polypide in bile duct, detecting tens ascarids at little enteral, intestinal is congested, hemorrhage, diagnoses as ascaris suum sick. To the carbolic acid solution thorough disinfection with thermokalite water or new fresh lime and 5%��10% of the morbidity pigsty, affected pig group using medicine prepared by embodiment 12 gavage by using dosage 5mL/Kg body weight simultaneously and treats, full group is used in conjunction 7 days. Through the treatment of 3 days, the whole affected pig in pig farm was got well.

Above-described is only the preferred embodiment of the present invention, it is noted that for a person skilled in the art, without departing under general idea premise of the present invention, it is also possible to making some changes and improvements, these also should be considered as protection scope of the present invention.

Claims (10)

1. a herbal medicine with stomach invigorating function for expelling pests, it is characterised in that formula is made up of the raw material of following weight portion: Fructus Crataegi 15��50 parts, Semen Raphani 15��40 parts, Massa Medicata Fermentata 15��40 parts, Semen Arecae 10��30 parts, Fructus Quisqualis 5��25 parts, Semen Torreyae 10��30 parts, Rhizoma Osmundae 10��30 parts.

2. there is the herbal medicine of stomach invigorating function for expelling pests as claimed in claim 1, it is characterized in that described formula is made up of the raw material of following weight portion: Fructus Crataegi 20��30 parts, Semen Raphani 20��30 parts, Massa Medicata Fermentata 20��30 parts, Semen Arecae 10��20 parts, Fructus Quisqualis 5��15 parts, Semen Torreyae 10��20 parts, Rhizoma Osmundae 10��20 parts.

3. there is the herbal medicine of stomach invigorating function for expelling pests as claimed in claim 1 or 2, it is characterised in that described formula is made up of the raw material of following weight portion: Fructus Crataegi 25 parts, Semen Raphani 25 parts, Massa Medicata Fermentata 25 parts, Semen Arecae 15 parts, Fructus Quisqualis 10 parts, Semen Torreyae 10 parts, Rhizoma Osmundae 10 parts.

4. the preparation method of the herbal medicine with stomach invigorating function for expelling pests as described in any one of claim 1-3, it is characterized in that: Fructus Crataegi, Semen Arecae ethanol extraction that concentration obtains ethanol extraction concentrated solution, residue after extraction, Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae decocting, precipitate with ethanol, concentration, obtain water drug-decocting concentrating liquid, two kinds of concentrated solutions merge, adjust pH to 5.0-6.0, again precipitate with ethanol, after filtration filtrate add water and auxiliaries form.

5. the preparation method as claimed in claim 4 with the herbal medicine of stomach invigorating function for expelling pests, it is characterised in that: it is the ethanol of volume ratio 50%-100% used by described ethanol extraction.

6. the preparation method of the herbal medicine with stomach invigorating function for expelling pests as described in claim 4 or 5, it is characterised in that: described ethanol extraction is the ethanol adding solid-to-liquid ratio 3-10 times amount, extracts 1-4 time, each 1-4h.

7. the preparation method of the herbal medicine with stomach invigorating function for expelling pests as described in claim 4 or 5, it is characterised in that: described precipitate with ethanol again is to add ethanol to make ethanol volume by volume concentration be 40-90%.

8. the preparation method of the herbal medicine with stomach invigorating function for expelling pests as described in claim 4 or 5, it is characterised in that: described adjustment pH material is sodium hydrate aqueous solution, sodium bicarbonate aqueous solution or aqueous sodium carbonate.

9. the preparation method of the herbal medicine with stomach invigorating function for expelling pests as described in claim 4 or 5, it is characterised in that described adjuvant is sodium benzoate or sorbic acid.

10. the preparation method of the herbal medicine with stomach invigorating function for expelling pests as described in claim 4 or 5, it is characterised in that: Fructus Crataegi, Semen Arecae add 5 times amount volume ratios and are 85 DEG C of reflux, extract, of 80% ethanol 2 times, each 2h, united extraction liquid, filter, and concentration is standby; Residue and Semen Raphani, Massa Medicata Fermentata, Fructus Quisqualis, Semen Torreyae, Rhizoma Osmundae add 10 times amount distilled water and decoct 3 times, and before decocting, Massa Medicata Fermentata gauze wraps up, and Fructus Quisqualis is smashed to pieces; Each 1h, merges decoction liquor, filters, concentration, adds ethanol and makes ethanol volume by volume concentration be 50%, and precipitate with ethanol stands, filters, concentration, standby; Merge two kinds of extracting solution, mixing, regulate pH to 5.0, adding ethanol makes ethanol volume by volume concentration be 75%, and precipitate with ethanol stands, supernatant concentrating under reduced pressure, filters, adds the sodium benzoate that mass volume ratio is 0.2%, dissolve, filter, add distilled water and be adjusted to every ml and be equivalent to crude drug 1g, embedding, sterilizing, packaging, to obtain final product.