CN103263483B - Medicament used for treating livestock virus and bacteria infections and prepared from traditional Chinese medicines and preparation method of medicament - Google Patents

Abstract

The invention relates to a medicament used for treating livestock virus and bacteria infections and prepared from traditional Chinese medicines. Raw material medicines including cardinal flowers, pericarpium granati, mangnolia officinalis, semen plantaginis and myrobalan are made into oral liquid or powder. The preparation method comprises the following steps of: removing impurities in the raw material medicines; frying the pericarpium granati with vinegar until the surface is yellowish-brown, and cooling the pericarpium granati; smashing the pericarpium granati fried with the vinegar, the cardinal flowers, the mangnolia officinalis, the semen plantaginis and the myrobalan; carrying out disinfection and sterilization to obtain raw material powder. Or the preparation method also comprises the following steps of: preparing the raw material medicines into a water extract according to a conventional method; preparing the water extract into the oral liquid according to a conventional method or preparing the water extract into water extract powder according to a conventional method. The medicament has reasonable compatibility, is warm but not dry, has moderate softness, has the function of strengthening the spleen and stomach, and can be widely suitable for pigeon and gallinaceous circovirus, porcine reproductive and respiratory syndrome, cough, piglet yellow, pullorosis, medium and small porcine enteritis, myocarditis and the like. The medicament prepared by pure traditional Chinese medicines has the advantages of scientific prescription, significant effect, safety and reliability, is convenient to use, has no toxic or side effect on liver, kidney, lung, stomach and spleen, and can be used for a long time.

Description

Medicament caught with the treatment poultry virus and bacteria of Chinese drug preparation and preparation method thereof

Technical field

The present invention relates to medicament of a kind for the treatment of diseases of bird and livestock of Chinese drug preparation and preparation method thereof, specifically medicament of catching of a kind for the treatment of poultry virus and bacteria of Chinese drug preparation and preparation method thereof.

Background technology

Animal proteinum in people's food is mainly derived from the poultry such as pig, cattle, sheep, chicken, duck, goose of artificial breeding, and these poultry mostly are scale artificial culture at present.Poultry treatment of disease in large-scale cultivation is vital, and often a disease can not get timely treatment, will involve the poultry all raised, even all dead time serious.Be at present poultry disease therapy many employings Western medicine, western medicine disease has drug effect feature fast, but excessive use Western medicine, particularly antibiotics, and these medicines will enrichment in poultry health, and people will have a negative impact to health after eating.The life-time service of Western medicine, the health of poultry also can produce drug resistance.Antibiotic is substantially invalid to the disease of poultry viral infection, and the cost of Western medicine is also higher.

Summary of the invention

The object of the invention is to the weak point for overcoming western medicine diseases of bird and livestock, the technical scheme of medicament that the treatment poultry virus and bacteria proposing a kind of Chinese drug preparation catches and preparation method thereof.

Technical scheme of the present invention: the medicament caught with the treatment poultry virus and bacteria of Chinese drug preparation, is characterized in that, it is made up of the crude drug of following weight percentage ratio:

Herba Alternantherae sessilis 33-35% Pericarpium Granati 25-33% Cortex Magnoliae Officinalis 13-15%

Semen Plantaginis 8-10% Fructus Chebulae 12-15%.

Described medicament is oral liquid or powder.

The preparation method of the medicament caught with the treatment poultry virus and bacteria of Chinese drug preparation, concrete steps are as follows:

(1) crude drug remove impurity;

(2) Pericarpium Granati vinegar is fried to surface is micro-yellowish-brown, matter is dry, crisp, have the smell of vinegar, cooling;

(3) Pericarpium Granati of vinegar parch, Herba Alternantherae sessilis, Cortex Magnoliae Officinalis, Semen Plantaginis and Fructus Chebulae powder are broken to 50-80 order;

(4) sterilization is raw material powder.

The preparation method of the medicament caught with the treatment poultry virus and bacteria of Chinese drug preparation, concrete steps are as follows:

(1) crude drug is made as according to a conventional method the aqueous extract that water content is 10%;

(2) by conventional method, the aqueous extract that step (1) is obtained is made as oral liquid;

(3) the extracting solution conventional method that step (2) is obtained is made as extracting solution powder.

In the Chinese medicine that the present invention chooses: Herba Alternantherae sessilis, sweet in the mouth, cold in nature.GUIXIN; Stomach; Small intestine meridian.There is cool the blood dissipate blood stasis; Heat-clearing and toxic substances removing; Dehumidify treating stranguria effect.Cure mainly hemoptysis; Spit blood; Have blood in stool; Jaundice due to damp-heat; Dysentery; Have loose bowels; Gingival swelling and pain; Laryngopharynx swelling and pain; Intestinal carbuncle; Acute mastitis; To itch the cheek; Swollen ulcer drug; Eczema; Stranguria; Traumatic injury; Venom etc.

Pericarpium Granati, sour in the mouth; Puckery; Warm in nature; Slightly poisonous.Return large intestine channel.Function: relieving diarrhea with astringents; Hemostasis; Anthelmintic; Dysentery; Discharging fresh blood stool; Metrorrhagia; Leukorrhagia; Insect.Cure mainly: epistaxis; Otitis media; Wound hemorrhage; Menoxenia; Redly collapse leucorrhea; Toothache; Spit blood; Chronic diarrhea; Chronic dysentery; Have blood in stool; Proctoptosis; Spermatorrhea; Metrorrhagia; Leukorrhagia; Abdominal pain due to worm stagnation; Scabies.Experiment shows, Pericarpium Granati all has inhibitory action to 7 kinds of Gram-negative intestinal content pathogenic bacterium such as escherichia coli, bacterium sonnei, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, pseudomonas aeruginosa, vibrio cholera.

Cortex Magnoliae Officinalis, nature and flavor: bitter; Pungent; Warm in nature.Return spleen, stomach, large intestine channel.Function: circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Cure mainly: stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant stops up QI rising in reverse order; Fullness in the chest is breathed with cough.

Semen Plantaginis, nature and flavor: sweet; Light; Cold nature.Gui Jing: return lung meridian; Liver Channel; Kidney channel; Urinary bladder channel.Function: clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Improving eyesight; Eliminate the phlegm.Cure mainly: main dysuria; Stranguria with turbid discharge leukorrhagia; Edema distension; Heat-damp in summer dysentery; Conjunctival congestion is hidden from view; Expectorant heat syndrome cough is breathed heavily.

Fructus Chebulae, Latin Frctus Terminaliae Chebulae, function: astringe the lung; Astringing intestine to stop diarrhea; The therapeutic method to keep the adverse QI flowing downwards; Sore-throat relieving.Cure mainly: chronic diarrhea; Chronic dysentery; Proctoptosis; To breath with cough phlegmatic cough; Chronic cough aphonia.

The present invention mainly identifies and corrects the principle treated according to China's Chinese medicine, and based on modern medicine to the understanding of the disease pathogenesis such as poultry porcine circovirus, reproductive and respiratory syndrome, cough, piglet Huang, chicken and duck Hakuri, medium and small swine enteritis, Medulla sus domestica myocarditis and Therapeutic Principle, reference is pharmacological research achievement at all times, the understanding of disease, the clinical practice through long-term treatment poultry case is summed up and is formed.The dialectical principle treated acted on by medicine of the present invention, chooses the accurate compatibility of medicine.Medicine of the present invention is mainly cool the blood dissipate blood stasis; Heat-clearing and toxic substances removing, relieving diarrhea with astringents, circulation of qi promoting removing food stagnancy, dampness is removed full, lowering the adverse QI to relieve asthma. clearing away heat and promoting diuresis, eliminating dampness by diuresis antidiarrheal.Cortex Magnoliae Officinalis circulation of qi promoting removing food stagnancy in formula; Dampness is removed full, sour and astringent intestinal tract function promoting and dysentery relieving; Semen Plantaginis diuresis row water, makes water wet to go out from urine, contributes to the use of dysentery relieving; Fructus Chebulae's relieving dysentery with astringents.Preparation of the present invention is received and not puckery, temperature and not dry, invigorating the spleen and regulating the stomach and do not stay cold-evil, pure and impure shunt, and convenient to both suitable, all dysentery is from disappearing.Compatibility of the present invention is reasonable, though and solid not secret, and temperature is not dry, and admittedly moisten appropriateness, invigorating the spleen and regulating the stomach, can the disease such as porcine circovirus, reproductive and respiratory syndrome, cough, piglet Huang, chicken and duck Hakuri, swine enteritis, Medulla sus domestica myocarditis being widely used in pig, chicken, duck.The present invention adopts pure Chinese medicine to make, and scientific formula is evident in efficacy, esy to use, safe and reliable, all has no side effect to liver, kidney, lung, stomach, spleen, can life-time service.

With raw material powder mix fodder when the present invention uses, feedstuff per ton adds 6-20 kilogram of raw material powder, uses extracting solution powder to reduce by half, feeds poultry, take 3-10 days with this feedstuff.

clinical trial data:

pig circular ring virus (eircovims)

20, certain pig farm pig, in 12 week age, generation dermatitis and pig do not eat food, and body temperature is increased to 41.5 DEG C, most sick pig subcutaneous dropsy, and aubergine pathological changes speckle appears in skin, some pig dysentery and dyspnea, by hair slightly disorderly.Through Disease Diagnosis of Veterinary be porcine circovirus (eircovims) infect.Use Multiple Classes of Antibiotics therapeutic effect undesirable.With raw material powder mix fodder of the present invention, feedstuff per ton adds 20 kilograms, uses extracting solution powder to reduce by half, and feeds sick pig, takes 3 days, have the symptom of 5 sick pigs entirely to disappear, recovery from illness with the feedstuff mixing medicine; 17 sick pig symptoms alleviate, and have 3 sick pig symptoms not change.The pig of recovery from illness is normally raised, and all the other 15 sick pigs continue to take the feedstuff mixing medicine, and have again 12 pig recoveries from illness after 5 days, 3 pig symptoms alleviate.The pig of recovery from illness is normally raised, and all the other 3 sick pigs continue to take the feedstuff mixing medicine, fully recover after 2 days.Tracing observation 30 days, has no adverse reaction and side effect.

reproductive and respiratory syndrome

30, certain pig farm pig, bred pigs.There is eyes swelling, conjunctivitis after there's a sudden fall in temperature, have gum or purulent secretion, and occur dyspnea, have sharp ears is blue, the symptom such as depressed lethargy.Boar shows cough, spirit depressed, inappetence, rapid breathing after infecting.Be the reproductive and respiratory syndrome that pig reproduction and breathing syndrome virus cause through Disease Diagnosis of Veterinary.With extracting solution powder mix fodder of the present invention, feedstuff per ton adds 10 kilograms, feeds sick pig, takes 3 days, have the symptom of 7 sick pigs entirely to disappear, recovery from illness with the feedstuff mixing medicine; 18 sick pig symptoms alleviate, and have 5 sick pig symptoms not change.The pig of recovery from illness is normally raised, and all the other 23 sick pigs continue to take the feedstuff mixing medicine, and have again 16 pig recoveries from illness after 7 days, 7 pig symptoms alleviate.The pig of recovery from illness is normally raised, and all the other 7 sick pigs continue to take the feedstuff mixing medicine, fully recover after 2 days.Tracing observation 30 days, has no adverse reaction and side effect.

pig cough

10, certain pig farm sow, cough occurs after there's a sudden fall in temperature and breathes, cardinal symptom is cough, mostly occurs at first when sooner or later searching for food or move or when there was an abrupt change in weather, cold air irritate or drive or feeding time more easily occur.Mostly be monophone dry cough, flow out a small amount of viscosity nose liquid or purulence nose liquid simultaneously.Increasing the weight of with the state of an illness, cough is also more violent, and number of times also increases thereupon, changes liaison many sound cough caused by pathogenic damp into.Plant oneself during sick pig cough, hogback stretches neck, and head hangs down into ground plane, until the secretions expectoration of respiratory tract comes or swallows.3 sick pigs are had to breathe, stomach wall is agitated with having the rhythm and pace of moving things, and frequency of respiration is 40-70 time per minute, has 1 sick pig rapid breathing, frequency of respiration increases, sick pig is that dog sits gesture, and mouth breathing, expresses one's feelings very painful, cough is long and sink weak, seemingly there is block of secretion respiratory tract, be difficult to expectoration, down in spirits poor appetite.Being epidemic swine pneumonia through Disease Diagnosis of Veterinary, is a kind of chronic respiratory contagious disease.Mycoplasma pneumoniae of swine, also known as epidemic swine pneumonia, pig Mycoplasma hyopneumoniae, is a kind of chronic respiratory contagious disease.With cough, breathe for cardinal symptom.Primary disease all can occur at present in various places, various kind, sex, the pig at age, but suckling pig, just ablactational baby pig and the sow of latter half of gestation and age of sucking more easily occur.With raw material powder mix fodder of the present invention, feedstuff per ton adds 10 kilograms, feeds sick pig, takes 3 days, have the symptom of 4 sick pigs entirely to disappear, recovery from illness with the feedstuff mixing medicine; 5 sick pig symptoms alleviate, and have 1 sick pig symptom not change.The pig of recovery from illness is normally raised, and all the other 6 sick pigs continue to take the feedstuff mixing medicine, and have again 5 pig recoveries from illness after 2 days, 1 pig symptom alleviates.The pig of recovery from illness is normally raised, and all the other 1 sick pigs continue to take the feedstuff mixing medicine, fully recover after 2 days.Tracing observation 30 days, has no adverse reaction and side effect.

piglet is yellow

10, certain pig farm piglet, in 2 days puerperal, has that 4 sick piglets are suffered from diarrhoea suddenly, feces is yellow pulp pasty state or yellow water sample, and containing curdled milk small pieces.Because struggling or piping, abdominal pressure can be increased and often discharges loose stool by anus, spray in water sample when sick piglet slack anus, seizure.The course of disease is slightly grown, becomes thin very soon, is dewatered.Be yellow dysentery of piglet through Disease Diagnosis of Veterinary.Yellow scour of piglet is again early onset colibacillosis, is that the one of the newborn piglet caused by the escherichia coli of certain serotype is acute, lethal infectious diseases.Pour in piglet mouth with oral liquid of the present invention, every day 3 times, each 20 milliliters, take 3 days, have the symptom of 3 sick pigs entirely to disappear, recovery from illness; 5 sick pig symptoms alleviate, and have 2 sick pig symptoms not change.The pig of recovery from illness is normally raised, and all the other 7 sick pigs continue to take oral liquid, and have again 5 pig recoveries from illness after 3 days, 2 pig symptoms alleviate.The pig of recovery from illness is normally raised, and all the other 2 sick pigs continue to take oral liquid, fully recover after 2 days.Tracing observation 30 days, has no adverse reaction and side effect.

pullorum Disease

Certain chicken farm chicken in 30 day age, 30 there is down in spirits, drop-head, and wing is sagging, and draw stock white pasty state loose stool, anus is often clung by feces, send " creak, creak " cry during defecation.Be Pullorum Disease through Disease Diagnosis of Veterinary, be caused by Salmonella pullon, its Excreta is important communication media.Normally employing, Norfloxacin in treatment of male.Sick chicken isolation, with raw material powder mix fodder of the present invention, feedstuff per ton adds 6-8 kilogram, feeds sick chicken, takes 3 days, have the symptom of 11 sick chickens entirely to disappear, recovery from illness with the feedstuff mixing medicine; 13 sick chicken symptoms alleviate, and have 6 sick chicken symptoms not change.The chicken of recovery from illness is normally raised, and all the other 19 sick chickens continue to take medicated feed, and have again 15 chicken recoveries from illness after 2 days, 4 chicken symptoms alleviate.The chicken of recovery from illness is normally raised, and all the other 4 sick chickens continue to take medicated feed, fully recover after 2 days.Tracing observation 30 days, has no adverse reaction and side effect.

swine enteritis

30, pig farm, Yunnan pig, 10 week age pig.Suddenly violent and lasting diarrhoea is there is, the rare soft or water sample of excrement, stench or stench after pig feed varietal change.Poor appetite or do not eat, happiness drinking-water, occur together vomiting, and spirit is tired, and happiness is sleeping, and sick just body temperature rises to 40 DEG C-41 DEG C, the loose stool that anus and afterbody glue, fecal incontinence sometimes.Have 2 person's of being in a bad way myasthenia of limbs, eye socket is spoilt sunken, temperature decline, cachexia and dead.Be swine enteritis through Disease Diagnosis of Veterinary.With raw material powder mix fodder of the present invention, feedstuff per ton adds 20 kilograms, feeds sick pig, takes 3 days, have the symptom of 9 sick pigs entirely to disappear, recovery from illness with the feedstuff mixing medicine; 16 sick pig symptoms alleviate, and have 5 sick pig symptoms not change.The pig of recovery from illness is normally raised, and all the other 21 sick pigs continue to take the feedstuff mixing medicine, and have again 15 pig recoveries from illness after 2 days, 6 pig symptoms alleviate.The pig of recovery from illness is normally raised, and all the other 6 sick pigs continue to take the feedstuff mixing medicine, and feedstuff per ton adds 10 kilograms, fully recovers after 2 days.Tracing observation 30 days, has no adverse reaction and side effect.

medulla sus domestica myocarditis

Shanxi plant 30 70 age in days pigs, intermittent dysentery first quarter moon, sick pig body weight size is uneven, severe patient differs more than 20 jin with health pig, by hair slightly disorderly, and row's cement-like loose stool, feces does not digest food-residue as seen, the heating 41 DEG C ~ 42 DEG C of the sick pig visible short time of serious attack, spirit is depressed, subtract food or stop eating, and some pig performances are trembled, lurch, vomit, dyspnea, or show progressive paralysis.In feedstuff, once added LIJUNJING, neomycin, injected the medicines such as oxytetracycline, Herba Macleayae Cordatae, ofloxacin, cephalo, and be showed no improvement.Be swine enteritis through Disease Diagnosis of Veterinary.Medulla sus domestica myocarditis is also known as pig virus encephalomyo-carditis.Infect by encephalomyocarditis virus a kind of high to the piglet fatality rate Natur al foca infectious disease caused.With encephalitis, myocarditis and heart perimyositis for principal character.With raw material powder mix fodder of the present invention, feedstuff per ton adds 20 kilograms, feeds sick pig, takes 3 days, have the symptom of 9 sick pigs entirely to disappear, recovery from illness with the feedstuff mixing medicine; 16 sick pig symptoms alleviate, and have 5 sick pig symptoms not change.The pig of recovery from illness is normally raised, and all the other 21 sick pigs continue to take the feedstuff mixing medicine, and have again 15 pig recoveries from illness after 2 days, 6 pig symptoms alleviate.The pig of recovery from illness is normally raised, and all the other 6 sick pigs continue to take the feedstuff mixing medicine, and feedstuff per ton adds 10 kilograms, fully recovers after 2 days.Tracing observation 30 days, has no adverse reaction and side effect.

Detailed description of the invention

1, with the raw material powder that the treatment poultry virus and bacteria of Chinese drug preparation catches

With the raw material powder that the treatment poultry virus and bacteria of Chinese drug preparation catches, be made up of the crude drug of following weight percentage ratio, the concrete quantity of crude drug of each embodiment is in table 1:

Herba Alternantherae sessilis 33-35% Pericarpium Granati 25-33% Cortex Magnoliae Officinalis 13-15%

Semen Plantaginis 8-10% Fructus Chebulae 12-15%.

Preparation method, concrete steps are as follows:

(1) crude drug remove impurity;

(2) Pericarpium Granati vinegar is fried to surface is micro-yellowish-brown, matter is dry, crisp, have the smell of vinegar, cooling;

(3) Pericarpium Granati of vinegar parch, Herba Alternantherae sessilis, Cortex Magnoliae Officinalis, Semen Plantaginis and Fructus Chebulae powder are broken to 50-80 order;

(4) sterilization is raw material powder.

2, the oral liquid caught with the treatment poultry virus and bacteria of Chinese drug preparation and extracting solution powder thereof

With the raw material powder that the treatment poultry virus and bacteria of Chinese drug preparation catches, be made up of the crude drug of following weight percentage ratio, the concrete quantity of crude drug of each embodiment is in table 1:

Herba Alternantherae sessilis 33-35% Pericarpium Granati 25-33% Cortex Magnoliae Officinalis 13-15%

Semen Plantaginis 8-10% Fructus Chebulae 12-15%.

Preparation method, concrete steps are as follows:

(1) crude drug is made as according to a conventional method the aqueous extract that water content is 10%;

(2) by conventional method, the aqueous extract that step (1) is obtained is made as oral liquid;

(3) the aqueous extract conventional method that step (1) is obtained is made as extracting solution powder.

table 1

Sequence number

Title

Embodiment 1

Embodiment 2

Embodiment 3

Embodiment 4

Embodiment 5

1

Herba Alternantherae sessilis

33Kg

35Kg

34Kg

34，5kg

33.5kg

2

Pericarpium Granati

29kg

25kg

31kg

30kg

33kg

3

Cortex Magnoliae Officinalis

14kg

15kg

14kg

14.5kg

13kg

4

Semen Plantaginis

9kg

10kg

9kg

9kg

8kg

5

Fructus Chebulae

15kg

15kg

12kg

12kg

12.5kg

Claims (1)

1. with the medicament that the treatment poultry virus and bacteria of Chinese drug preparation catches, it is characterized in that, it is made up of the crude drug of following weight percentage ratio:

Herba Alternantherae sessilis 33-35% Pericarpium Granati 25-33% Cortex Magnoliae Officinalis 13-15%

Semen Plantaginis 8-10% Fructus Chebulae 12-15%.

2, the medicament that catches of the treatment poultry virus and bacteria of Chinese drug preparation according to claim 1, it is characterized in that, described medicament is oral liquid or powder.

3, the preparation method of medicament that catches of the treatment poultry virus and bacteria of Chinese drug preparation according to claim 1, it is characterized in that, concrete steps are as follows:

(1) crude drug remove impurity;

(2) Pericarpium Granati vinegar is fried to surface is micro-yellowish-brown, matter is dry, crisp, have the smell of vinegar, cooling;

(3) Pericarpium Granati of vinegar parch, Herba Alternantherae sessilis, Cortex Magnoliae Officinalis, Semen Plantaginis and Fructus Chebulae powder are broken to 50-80 order;

(4) sterilization is raw material powder.

4, the preparation method of medicament that catches of the treatment poultry virus and bacteria of Chinese drug preparation according to claim 1, it is characterized in that, concrete steps are as follows:

(1) crude drug is made as according to a conventional method the aqueous extract that water content is 10%;

(2) by conventional method, the aqueous extract that step (1) is obtained is made as oral liquid;

By conventional method, the aqueous extract that step (1) is obtained is made as extracting solution powder.