CN105688157A - Traditional Chinese medicine compound preparation for resisting swine influenza virus and preparing method thereof - Google Patents
Traditional Chinese medicine compound preparation for resisting swine influenza virus and preparing method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
Abstract
The invention belongs to a traditional Chinese medicine compound preparation for resisting a swine influenza virus and a preparing method thereof. The traditional Chinese medicine compound preparation is prepared from, by weight, 10-15 parts of fineleaf schizonepeta herb, 5-15 parts of honeysuckle flowers, 5-15 parts of fructus arctii, 10-15 parts of radix bupleuri, 5-10 parts of rhizoma zingiberis, 5-15 parts of houttuynia cordata, 10-20 parts of radix isatidis, 10-20 parts of poria cocos, 10-30 parts of shikimic acid and 5-10 parts of allicin. The traditional Chinese medicine compound preparation is reasonable in compatibility and capable of remarkably improving livestock and poultry organism immunity, enhancing disease resistance, well inhibiting diseases caused by influenza viruses and treating bacteriosis caused by secondary infection; the raw materials are wide in source, and the production process is simple. The mixture is ultrafine powder, the fineness can reach 200 mesh, the mixture is easy to absorb after entering the organism, clinic delivery is convenient, and the traditional Chinese medicine compound preparation is suitable for group drug delivery and saves manpower and material resources. The drug content is clear and definite, drug delivery is accurate, and quality is controllable.
Description
Technical field
The invention belongs to field of traditional Chinese, particularly relate to a kind of compound Chinese medicinal preparation for anti-swine flu virus and preparation method thereof。
Background technology
Swine influenza virus is one of current modal porcine respiratory virulence factor, often cause certain loss due to the mixed infection with other cause of diseases to pig farm, and this virus easily morphs, i.e. antigenic drift and antigenic shift, fowl between the kind of---pig---people in communication process, play intermediate host and the role of multiple host, health and public health on people and other animals have very big impact。Furthermore, swine flue also Chang Jifa or concurrent swine mycoplasma pneumonia, Porcine reproductive and respiratory syndrome, actinobacillus pleuropneumoniae infection etc., bring very big economic loss to pig farm and cause serious environmental pollution。
Owing to Western medicine prolonged application is easily generated drug resistance and lessens the curative effect, cause very big drug residue simultaneously, therefore Western medicine has significant limitation when treating swine influenza virus disease, and Chinese medicine and compound recipe thereof have suppression virus replication, comprehensive effect such as adjustment immunologic function, easing pain and diminishing inflammation etc., therefore, Chinese medicine has the advantage of uniqueness in preventing and treating influenza infection。
Summary of the invention
It is an object of the invention to provide a kind of be readily absorbed by, convenient drug administration, safely and effectively for compound Chinese medicinal preparation of anti-swine flu virus and preparation method thereof。
For achieving the above object, the technical solution used in the present invention is, a kind of compound Chinese medicinal preparation for anti-swine flu virus, is made up of the raw material of following portions by weight: Herba Schizonepetae 10-15 part, Flos Lonicerae 5-15 part, Fructus Arctii 5-15 part, Radix Bupleuri 10-15 part, Rhizoma Zingiberis 5-10 part, Herba Houttuyniae 5-15 part, Radix Isatidis 10-20 part, Poria 10-20 part, shikimic acid 10-30 part, garlicin 5-10 part。
Preferably, the described compound Chinese medicinal preparation for anti-swine flu virus, is made up of the raw material of following portions by weight: Herba Schizonepetae 10 parts, Flos Lonicerae 6 parts, Fructus Arctii 5 parts, Radix Bupleuri 15 parts, Rhizoma Zingiberis 8 parts, Herba Houttuyniae 6 parts, Radix Isatidis 10 parts, 10 parts of Poria, shikimic acid 20 parts, garlicin 10 parts。
The preparation method of the described compound Chinese medicinal preparation for anti-swine flu virus, comprise the following steps: take each raw material in proportion, Herba Schizonepetae, Flos Lonicerae, Fructus Arctii, Radix Bupleuri, Rhizoma Zingiberis, Herba Houttuyniae, Radix Isatidis, Poria are carried out respectively micronizing (being crushed to below 200 orders), then the above-mentioned each material after micronizing and shikimic acid, garlicin are placed in mixer, stir, obtain the described compound Chinese medicinal preparation for anti-swine flu virus。
Herba Schizonepetae, acrid in the mouth；Micro-hardship；Slightly warm in nature。Return lung；Liver Channel。Dispel the wind；Induce sweat；Rash；Hemostasis。There is following pharmacological action: 1, antipyretic effect: the d-menthone in Herba Schizonepetae is analgesic main component, and 3-methyl cyclohexanone also has analgesic activity；2, antiviral: infected by influenza has inhibitory action；3, antibacterial action: staphylococcus aureus and diphtheria corynebacterium are had stronger antibacterial action by Herba Schizonepetae decoct in vitro tests, secondly all shows certain inhibitory action to anthrax bacillus, group B streptococcus, Bacillus typhi, dysentery bacterium, bacillus pyocyaneus, Bacillus tuberculosis etc.；4, anastalsis；5, antiinflammatory action。
Flos Lonicerae, is described as the good medicine of heat-clearing and toxic substances removing from ancient times。Its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and do not injure one's stomach, fragrance thoroughly reaches and can be eliminating evil。Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile diseases, such as fever of the body, dermexanthesis, send out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal effect is notable。Concrete effect is as follows: 1, resisting pathogenic microbes effect, and various pathogens such as staphylococcus aureus, Hemolytic streptococcus, escherichia coli, dysentery bacterium, vibrio cholera, Bacillus typhi, Salmonella paratyphi etc. are all had certain inhibitory action；2, bactericidal action, has antibacterial and bactericidal action to streptococcus pneumoniae, meningococcus, pseudomonas aeruginosa, tubercule bacillus, dysentery bacterium, Streptococcus mutans etc., and infected by influenza, herpesvirus, leptospira all have inhibitory action；3, dredge heat and dissipate heresy effect, to affection due to external wind and heat or epidemic febrile disease from the beginning of, fever of the body headache, vexed sleep less, coma crimson tongue, dry mouth and throat etc. have certain effect；4, eliminating pathogenic heat from blood to cure dysentery effect, to pyretic toxicity dysentery, dysentery pus and blood, hygropyrexia resistance larynx, laryngopharynx swelling and pain etc. have removing toxic substances dysentery relieving removing heat from blood sore-throat relieving effect；5, eliminating inflammation and expelling toxin effect, has stronger scattered carbuncle to subside a swelling carbuncle furuncle, acute appendicitis lung abscess, antipyretic and antidote functions。
Fructus Arctii, for the dry mature fruit of Compositae biennial herb plant Fructus Arctii (formal name used at school: ArctiumlappaL.)。Acrid in the mouth；Bitter；Cold in nature。Return lung；Stomach warp。There is dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, effect of removing toxic substances and promoting subsidence of swelling。Fructus Arctii can suppress the titer of influenza virus, and extract can reduce clotting potency, extends the time suppressing virus。Can also prevent and protect the embryo for the treatment of influenza virus infection, and during high concentration, preventive effect is substantially better than virazole, also has very strong antiinflammatory action simultaneously。
Radix Bupleuri, nature and flavor are bitter, be slightly cold, and return liver, gallbladder meridian。There are reconciling superficies and interior, effect of soothing the liver yang invigorating。For cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver。Mainly having antipyretic-antalgic, calmness, antiinflammatory, liver-protective effect, infected by influenza has very strong inhibitory action simultaneously, also can improve the immunity of body。
Rhizoma Zingiberis, acrid in the mouth, hot in nature。Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warming the lung to resolve fluid-retention。There is facilitating digestion, blood circulation promoting, antiinflammatory, analgesia and antithrombotic effect。
Herba Houttuyniae, heat-clearing and toxic substances removing；Removing pus and relieving carbuncle；Inducing diuresis for treating stranguria syndrome。Cure mainly the main lung abscess vomiting pus of pyretic stranguria；Expectorant dyspnea of heat type is coughed；Larynx；Hematodiarrhoea；Carbuncle sore tumefacting virus；Pyretic stranguria。The phagocytic activity of WBC can be strengthened, improve immunity of organisms, there is antiinflammatory action, various microorganisms (especially yeast and mycete) are all had inhibitory action, the streptococcus of hemolytic, staphylococcus aureus, hemophilus influenza, micrococcus catarrhalis, streptococcus pneumoniae are had obvious inhibitory action。Escherichia coli, dysentery bacterium, Bacillus typhi also there is effect。Influenza A virus there is good inhibiting effect。
Radix Isatidis is the dry root of cruciferae isatis；Nature and flavor bitter cold；There is effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, sore-throat relieving；Curing mainly fever caused by exogenous pathogens, epidemic febrile disease is from the beginning of, laryngopharynx swelling and pain；Maculae caused by violent heat pathogen, mumps, erysipelas, too fat to move sore。Modern pharmacology research shows, Radix Isatidis has antiinflammatory, antiviral, antipyretic and improve the effect such as immunity。
Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming；Modern medicine study: Poria energy enhancing human body immunity function, and have effect antibacterial, antiviral。
Shikimic acid, is present in a large amount of higher plant or microorganism。Well-known people is through what the further derivatization of shikimic acid obtained with influenza new drug " oseltamivir phosphate capsule "。Primary boycott virion discharges from cell, thus stoping it to infect normal cell further, plays the effect of rapid symptom management。Oral absorption is good, and bioavailability is high, and directional profile is in positions such as pulmonary, bronchus, nasal sinuses, middle ear in vivo, and antiviral effect is reliable, and infected by influenza has specially good effect。
Garlicin, for trithio allyl ether compounds, is naturally occurring in the bulb of liliaceous plant Bulbus Allii。Multiple Gram-positive and negative bacterium all there is antibacterial action, bacillus (dysentery bacterium, Bacillus typhi, escherichia coli, bordetella pertussis), fungus (Candida albicans, cryptococcus, Aspergillus fumigatus), virus (cytomegalovirus), ameba, trichomonas vaginitis, pinworm etc. all there are is suppression killing action, especially that the intestinal bacteria effect such as escherichia coli, dysentery bacterium is strong。There is the effect such as strong disinfecting, detoxication health care, raising immunity, mould-proof disinsectization, and can effectively suppress and kill the bacterial viruses such as the helicobacter pylori that causes gastroenteropathy, remove the intestines and stomach noxious substance, stimulating gastrointestinal mucosa, promote appetite。
It is known that improve immunity to be resistant to the committed step of all diseases, Chinese medicine and extract thereof just can effectively avoid Western medicine to reduce the defect of immunity。The present invention adopts the Chinese medicine of multiple resisiting influenza virus and carries out compatibility by the principle of the monarch and his subjects' assistant, safely and effectively, and noresidue, have no drug resistance。
The beneficial effect comprise that: the compatibility of (1) present invention is reasonable, can significantly improve the immunity of organisms of poultry, strengthen resistance against diseases, the disease that infected by influenza causes has good inhibiting effect, and has the bacterial disease treated because secondary infection causes；(2) inventive mixture abundant raw material source, and production technology is easy；(3) inventive mixture is ultra-micro powder, and fineness, up to 200 orders, is readily absorbed by after entering body, and clinical administration is convenient, is suitable for colony's administration, uses manpower and material resources sparingly；(4) medicament contg of the present invention is clear and definite, and administration is accurately, quality controllable。
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but protection scope of the present invention is not limited to this。
Embodiment 1
A kind of compound Chinese medicinal preparation for anti-swine flu virus, is made up of the raw material of following portions by weight: Herba Schizonepetae 15 parts, Flos Lonicerae 5 parts, Fructus Arctii 15 parts, Radix Bupleuri 10 parts, Rhizoma Zingiberis 5 parts, Herba Houttuyniae 15 parts, Radix Isatidis 20 parts, 20 parts of Poria, shikimic acid 10 parts, garlicin 5 parts。
The described preparation method for the compound Chinese medicinal preparation of anti-swine flu virus comprises the following steps: take each raw material in proportion, Herba Schizonepetae, Flos Lonicerae, Fructus Arctii, Radix Bupleuri, Rhizoma Zingiberis, Herba Houttuyniae, Radix Isatidis, Poria are carried out respectively micronizing (being crushed to below 200 orders), then the above-mentioned each material after micronizing and shikimic acid, garlicin are placed in mixer, stir, obtain the described compound Chinese medicinal preparation for anti-swine flu virus。
Embodiment 2
A kind of compound Chinese medicinal preparation for anti-swine flu virus, is made up of the raw material of following portions by weight: Herba Schizonepetae 10 parts, Flos Lonicerae 6 parts, Fructus Arctii 5 parts, Radix Bupleuri 15 parts, Rhizoma Zingiberis 8 parts, Herba Houttuyniae 6 parts, Radix Isatidis 10 parts, 10 parts of Poria, shikimic acid 20 parts, garlicin 10 parts。
The preparation method of the compound Chinese medicinal preparation for anti-swine flu virus of the present embodiment is identical with embodiment 1。
Embodiment 3
A kind of compound Chinese medicinal preparation for anti-swine flu virus, is made up of the raw material of following portions by weight: Herba Schizonepetae 12 parts, Flos Lonicerae 15 parts, Fructus Arctii 10 parts, Radix Bupleuri 12 parts, Rhizoma Zingiberis 10 parts, Herba Houttuyniae 5 parts, Radix Isatidis 15 parts, 15 parts of Poria, shikimic acid 30 parts, garlicin 8 parts。
The preparation method of the compound Chinese medicinal preparation for anti-swine flu virus of the present embodiment is identical with embodiment 1。
Application test
Select in October, 2014--give treatment to the growing and fattening pigs 60 in the doubtful swine flue in pig farm, Shangqiu during in April, 2015 as the respondent of this time research topic。Sick temperature of pig body raises and reaches 40 DEG C～41.5 DEG C, and spirit is depressed, loss of appetite or do not eat, myalgia, is reluctant to stand, and eye and nose have viscous liquid to flow out, conjunctival congestion, indivedual sick pig dyspnea, breathe, cough, in ventral breathing, there is sitting position of dog gesture, disease pig whoop can be heard at night, indivedual sick pig arthralgias, especially the morbidity of the growth of livestock good pig is more serious。Make a definite diagnosis 60 sick pigs and all meet the diagnostic criteria of swine flue。According to measurement, between 50～80kg not etc., the average weight of sick pig is (66.2 ± 4.8) kg to the body weight of 60 sick pigs of this group。Adopting random manner that the 60 of this group pigs are equally divided into observation group 1,2,3 and matched group, four groups of disease pig numbers are 15。
Matched group adopts the mode of western medicine that 15 sick pigs are treated, and all gives amantadine hydrochloride (South Sea, Foshan City Bei Sha pharmaceutical Co. Ltd) and florfenicol powder (Hebei Veyong Animal Pharmaceutical Co., Ltd.) is treated。Concrete usage and dosage is: every 1L water adds amantadine hydrochloride 0.1g and florfenicol powder 1g, continuous use 7-10d。
Observation group adopts the Chinese medicine preparation of embodiment 1,2,3 preparation respectively 15 sick pigs of observation group to be treated, and concrete usage and dosage is: mixed feeding, every 1000g spice 300kg, is used in conjunction 7-10d。
The therapeutic outcome of observation group 1-3 and matched group is in Table 1
The therapeutic outcome of table 1 observation group 1-3 and matched group
Note: effective refer to that the state of an illness is clearly better, body temperature is normal, and appetite substantially increases, and breathes normal, it does not have cough symptom of breathing, and conjunctival congestion eliminates；Effectively referring to that sb.'s illness took a favorable turn, body temperature is normal, and appetite increases, and breathes normal, has cough shape slightly, and eye conjunctiva has a small amount of hyperemia；Invalid refer to the state of an illness without take a turn for the better or increase the weight of。
As can be seen from Table 1, four groups of disease pigs are after accepting treatment, and clinical symptoms and sign all improve and control, and the total effective rate of the treatment of observation group disease pig is 95.5%, and the total effective rate of the treatment of matched group disease pig is 66.7%, the significant difference between two groups。Illustrate that swine influenza virus is had obvious effect by the compound Chinese medicinal preparation of the present invention。
Claims (3)
1. the compound Chinese medicinal preparation for anti-swine flu virus, it is characterized in that, be made up of the raw material of following portions by weight: Herba Schizonepetae 10-15 part, Flos Lonicerae 5-15 part, Fructus Arctii 5-15 part, Radix Bupleuri 10-15 part, Rhizoma Zingiberis 5-10 part, Herba Houttuyniae 5-15 part, Radix Isatidis 10-20 part, Poria 10-20 part, shikimic acid 10-30 part, garlicin 5-10 part。
2. the compound Chinese medicinal preparation for anti-swine flu virus as claimed in claim 1, it is characterized in that, be made up of the raw material of following portions by weight: Herba Schizonepetae 10 parts, Flos Lonicerae 6 parts, Fructus Arctii 5 parts, Radix Bupleuri 15 parts, Rhizoma Zingiberis 8 parts, Herba Houttuyniae 6 parts, Radix Isatidis 10 parts, 10 parts of Poria, shikimic acid 20 parts, garlicin 10 parts。
3. the preparation method of the compound Chinese medicinal preparation for anti-swine flu virus as claimed in claim 1 or 2, it is characterized in that, comprise the following steps: take each raw material in proportion, Herba Schizonepetae, Flos Lonicerae, Fructus Arctii, Radix Bupleuri, Rhizoma Zingiberis, Herba Houttuyniae, Radix Isatidis, Poria are carried out respectively micronizing, then the above-mentioned each material after micronizing and shikimic acid, garlicin are placed in mixer, stir, obtain the described compound Chinese medicinal preparation for anti-swine flu virus。
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106491664A (en) * | 2016-11-30 | 2017-03-15 | 广西壮族自治区动物疫病预防控制中心 | A kind of Chinese medicine composition for treating pig virus diarrhoea |
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| CN108743923A (en) * | 2018-06-28 | 2018-11-06 | 河南省帝方生物制药有限公司 | A kind of compound preparation and preparation method thereof for the antiviral raising immunity of livestock and poultry |
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Application publication date: 20160622 |