CN101209329A - Chinese medicinal oral liquid with heat-clearing and detoxication, lung-heat-clearing and cough-relieving efficacy - Google Patents
Chinese medicinal oral liquid with heat-clearing and detoxication, lung-heat-clearing and cough-relieving efficacy Download PDFInfo
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- CN101209329A CN101209329A CNA2006101305318A CN200610130531A CN101209329A CN 101209329 A CN101209329 A CN 101209329A CN A2006101305318 A CNA2006101305318 A CN A2006101305318A CN 200610130531 A CN200610130531 A CN 200610130531A CN 101209329 A CN101209329 A CN 101209329A
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Abstract
The invention relates to a traditional Chinese medicine oral liquor with the effects of clearing heat, removing toxicity, clearing lung and stopping cough, including white mulberry root-bark, common anemarrhena rhizome, bitter apricot seed, whiteflower hogfennel root, gypsum, weeping forsythiae capsule, loquat leaf, pumice, liquoric root, red orange and baical skullcap root. The invention is mainly used for treating swelling of the throat, cough and asthma, mouth breathing, respiratory tract rale and other symptoms which are caused by infectious bronchitis, laryngotracheitis, mycoplasma infection and other acute and chronic respiratory diseases. The symptoms of the respiratory diseases can disappear rapidly and not be recurrent by the usage at the early stage; the invention can decrease the mortality rate of the respiratory diseases rapidly by being matched with the antibiotic drugs at the advanced stage. The formula of the invention has the effects of clearing heat, removing toxicity, clearing lung and stopping cough. The medicine can be prepared into the oral liquor by the combination of the special physiological structure of the poultry, and the invention can be absorbed rapidly after drinking water, so as to achieve the purpose of rapid onset of action.
Description
Technical field
The invention belongs to field of veterinary, particularly relate to a kind of Chinese medicine oral liquid with heat-clearing and toxic substances removing, clearing away lung-heat to relieve cough effect.
Background technology
It is the common respiratory tract disease of chicken that chicken respiratory infects, and it is one of principal disease that threatens the aviculture sound development.In recent years, the respiratory tract disease of chicken scope and area at home constantly enlarges, and in the past few years successively breaks out repeatedly big popular.Data shows, outburst in various degree should disease be all arranged throughout the country in 2000, and the second half year in 2000, ground such as Jiangsu Province, Shandong Province have broken out infectious bronchitis in succession.The tall and big 30%-35% of the sickness rate of certain areas, mortality rate can reach 15%-25%, and is particularly serious to the infringement of laying hen.This disease is all contacts to some extent in the real work of various places.Why important respiratory tract disease is, often takes place on the one hand, and the chicken of various ages in days all can infect, and has a strong impact on the fertility performance of chicken, causes deterioration in quality, and the economic loss of Yin Faing is very serious thus; Be sickness rate height and the secondary infection that causes multiple disease easily on the other hand, can make the chick growth hypoevolutism, the chicken egg drop reduction of growing up and the chicken death that causes various ages in days, so respiratory disease of chicken is very important for the economic implications of poultry farming.
To so far, clinical main a large amount of antibiotic therapy that still relies on, the auxiliary treatment of its prevention secondary infection also is to cooperate antibiotic formulations to use, as sulfa drugs, penicillin, streptomycin, erythromycin, norfloxacin, enrofloxacin etc., not only very easily produce Resistant strain, and causing the livestock products residue of veterinary drug to exceed standard, human beings'health in serious harm.
Shortcomings such as the treatment by Chinese herbs of using clinically at present is should disease comparatively common, but preparation mostly is powder, and administration inconvenience is short because of the digestive tract of chicken again, can not digest lignocellulose, and the drug absorption that causes is poor, and consumption is big.
Summary of the invention
Based on above-mentioned situation, the present invention aims to provide a kind of Chinese medicine oral liquid with heat-clearing and toxic substances removing, clearing away lung-heat to relieve cough effect.
The object of the present invention is achieved like this: a kind of Chinese medicine preparation with heat-clearing and toxic substances removing, clearing away lung-heat to relieve cough effect, it is characterized in that: Cortex Mori 2-5 part, Rhizoma Anemarrhenae 2-4 part, Semen Armeniacae Amarum 2-4 part, Radix Peucedani 2-5 part, Gypsum Fibrosum 3-7 part, Fructus Forsythiae 3-7 part, Folium Eriobotryae 1-3 part, Pumex 1-3 part, Radix Glycyrrhizae 1-3 part, tangerine 2-5 part, Radix Scutellariae 3-7 part.
Be preferably: 3.5 parts of Cortex Mori, 3 parts of the Rhizoma Anemarrhenaes, 3 parts of Semen Armeniacae Amarums, 3.5 parts of Radix Peucedanis, 5 parts of Gypsum Fibrosum, 5 parts of Fructus Forsythiaes, 2 parts of Folium Eriobotryaes, 2 parts of Pumexs, 2 parts in Radix Glycyrrhizae, tangerine 3.5 parts, 5 parts of Radix Scutellariaes.
A kind of Chinese medicine preparation with heat-clearing and toxic substances removing, clearing away lung-heat to relieve cough effect is characterized in that: the dosage form of described Chinese medicine preparation is an oral liquid.
Main and auxiliary according to Chinese veterinarian, as to help, the make principles of formulating prescriptions, Cortex Mori, Semen Armeniacae Amarum clearing lung, relieving asthma in the side, inducing diuresis to remove edema has stable, analgesia, cooling, effect such as antibiotic, is the principal agent in the side; Clearing away heat-fire such as Gypsum Fibrosum, the Rhizoma Anemarrhenae has effects such as antibiotic, antiviral, analgesic, antiinflammatory, is accessory drugs; Radix Scutellariae, Fructus Forsythiae etc. have antibiotic, antiinflammatory is used for the disease of pathogenic heat for trouble, is adjuvant drug; The Radix Glycyrrhizae heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription is messenger drug in the side.All medicines share have cough-relieving, relieving asthma, the effect of antibiotic, antiviral.
The present invention adopts the industry method in common to make: above ten medical materials simply decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, being concentrated into relative density is the clear paste of 1.02 (80 ℃), and cold preservation 24 hours filters, filtrate adds sodium benzoate, stir evenly, packing, promptly.
Below with concrete description of test effect of the present invention:
1 material and method
1.1 test material
1.1.1 trial drug medicine main component of the present invention is Cortex Mori, the Rhizoma Anemarrhenae, Semen Armeniacae Amarum, Radix Peucedani, Gypsum Fibrosum etc., recommended dose 1.25ml/l water; Control drug is a MAXINGSHIGAN TANG, and lot number is that consumption is in crude drug, with reference to veterinary drug allusion quotation MAXINGSHIGANGSAN consumption.
1.1.2 laboratory animal 10 age in days SPF Embryo Gallus domesticus, factory provides by the Nanjing medical instruments; 550 of the healthy broiler of 1 age in days Ai Wei mattress are available from Nanjing six directions hatching factory.
1.1.3 bacterial strain and strain chicken respiratory type infectious bronchitis kind poison (IBV-M
41), malicious valency is 105.15/0.1ml.
Planting malicious rejuvenation and malicious valency measures: with the dilution in 1: 10 of lyophilizing kind poison, be inoculated in 0.1ml/ embryo in the 10 age in days SPF embryo allantoic cavitys, and behind 37 ℃ of cultivation 30-36h, aseptic collection allantoic fluid.Through check, venom is aseptic, and malicious valency is 106/0.1ml, uses for counteracting toxic substances.
1.2 test method
1.2.1 manual-induced chickling respiratory tract type infectious bronchitis trial test 15 ages in days are for 180 of examination chickens, body weight 135.4 ± 1.3g is divided into 5 contamination groups and 1 negative control group, 30 every group at random.Isolated rearing in the locellus cage, conventional feeding and management.Each contamination group chicken per nasal splashes into the confession prelibation liquid of varying number.The negative control group chicken is not contaminated.Can tracing observation chicken group and the check chicken that dies of illness according to its contamination morbidity and death time, quantity, this sick characteristic symptom and pathological changes occur, calculate the contrast case fatality rate, determine manual-induced this disease for prelibation drop nose amount.
Test 25 ages in days for 350 of examination chickens, body weight 181.5 ± 1.5g, grouping shown in subordinate list, contamination, administration, 3 weeks of tracing observation 1.2.2 treat manual-induced chickling respiratory tract type infectious bronchitis.Clinical change, pathology that chicken is respectively organized in contrast lapse to, and according to its cure rate, improvement rate, mortality rate, total effective rate etc., overall merit medicine of the present invention is to this sick curative effect.Grouping sees Table 1.
2 results
2.1 manual-induced chickling respiratory tract type bronchitis result of the test
According to this result of the test, give every to supply examination chickling per nasal to splash into 0.2ml for prelibation liquid, successfully induce respiratory tract type infectious bronchitis.
The grouping of table 1 test chicken
| Group | Test chicken number (only) | For the reagent thing | Drug level (ml/L water) | The medication natural law |
| 1 | 50 | Medicine high dose group of the present invention | 2.5 | 5 |
| 2 | 50 | Dosage group in the medicine of the present invention | 1.25 | 5 |
| 3 | 50 | Medicine low dose group of the present invention | 0.625 | 5 |
| 4 | 50 | MAXINGSHIGAN TANG contrast medicine group | 1.0 | 5 |
| 5 | 50 | Infect matched group | 0 | |
| 6 | 50 | Normal healthy controls (not infecting) group | 0 | |
| 7 | 50 | Safety of medicine dosage group of the present invention | 12.5 | 5 |
20-54h all falls ill 2.1.1 clinicing symptom observation contamination group chicken group contaminates, its cardinal symptom is uneasiness or somnolence, subtract food or useless food, happiness drink, squat crouch, long-pending heap, get rid of head, watery nasal discharge, sneeze, breath with cough, trachea hello sound, arrange rare white soft stool.The IB agar diffusion test is positive.Contamination back 3.5d begins to see dead chicken, continues to observe and a week sees dead chicken in the end again, and total fatality rate is 90%, and it is all dead to surpass this contamination amount group chicken, is lower than this contamination amount group chicken and presents morbidity and varying number death in various degree.The negative control group chicken is all strong to live.
Chicken is checked die of illness chicken nasal meatus, nasal sinuses, trachea, bronchial mucosa swelling 2.1.2 die of illness, and intracavity contains serosity, mucus or the cheesy exudate of varying number; Scatter little scorching kitchen range around the bronchus; The air bag muddiness; That renal swelling expands is pale, renal tubules and the full urate of ureter inner product; The Catarrhal enteritis, fabricius bursa and other internal organs end are seen unusually.Inspection of bacterium such as upper respiratory tract, lung, blood, liver,spleen,kidney and cultivation results are all negative.
To sum up the result all meets the clinical and characteristics of lesion of respiratory tract type infectious bronchitis and the law of mortality of falling ill.Confirm that this test chickling is by IBV-M
41Kind of poison morbidity causes death, and to bring out this disease for the contamination of chickling collunarium for the prelibation liquid measure feasible by above-mentioned.Manual-induced this sick chickling can be made for the Drug therapy test and use.
2.2 therapeutic outcome sees Table 2
2.2.1 clinical observation
The chicken of positive controls respiratory tract type infectious bronchitis symptom occurred in back about 1 day in succession in contamination, and the IB agar diffusion test is positive, 10 of duration of test survivals, and dead 20, mortality rate reaches 66.7%.The negative control group chicken is all strong to live.Respectively organize the chicken group back of contaminating for reagent and contrast medicine and the same time this sick characteristic symptom also occurs.Tracing observation is respectively organized the chicken group after the administration, and the height of medicine of the present invention, the middle dosage group chicken administration 2-3d state of an illness are clearly better, and its cure rate and total effective rate are shown in subordinate list, all apparently higher than the low dose group and the control drug group of medicine of the present invention.
2.2.2 cut open inspection and bacteriological analysis result by only cuing open each group of inspection chicken that dies of illness, and get tunica mucosa tracheae and scrape and get thing, lung tissue, blood, carry out bacteriological analysis, the result meets the characteristics of lesion of chicken respiratory type infectious bronchitis.
Table 2 medicine of the present invention is to the curative effect of respiratory infectious bronchitis test
2.2.3 the recurrence result of the test is scraped the tunica mucosa tracheae of the typical chicken that dies of illness of each group and is got thing and lung tissue homogenate, is inoculated in 16 26 healthy confessions of ages in days respectively and tries in the trachea of chicken.This sick characteristic symptom all appears behind the 27-28h, and all dead in the 8d; Cut open inspection and all see this sick characteristic pathological changes.Turn out to be infectious bronchitis virus and cause death.
2.2.4 off-test survival chicken assay has not this disease symptoms, pathological changes and degree thereof, the negative chicken number of bacterium inspection according to each administration group survival chicken, calculates such as the cure rate shown in the subordinate list, improvement rate, total effective rate.High dose medicine of the present invention is good to this sick curative effect in the affirmation.
3 discuss
3.1 medicine of the present invention is to the curative effect of infectious bronchitis
Medicine of the present invention is the new medicine compound preparation, and this test confirms that this medicine of chickling drink-service treatment respiratory tract type infectious bronchitis drug effect is certain, is suitable for applying in herding is produced.According to clinical trial, clinical using dosage is recommended as 1.25ml/L water, mix the drink administration.
3.2 the safety of medicine of the present invention
Show through the safety testing (10 times of recommended dose drinking-water, logotype 5 days) to healthy chicken, do not see clinical unusual performance between the operating period, healthy chicken is not had obvious influence, weight gain and blank group difference are not remarkable.Illustrate that this preparation is safe.
Beneficial effect of the present invention: prescription of the present invention has heat-clearing and toxic substances removing, the effect of clearing away lung-heat to relieve cough.In conjunction with birds reproductive tract weak point, can not digest the special physiological structure of wood fibre, medicine is made oral liquid, in feeding drinking-water, disperse rapidly, after the trouble chicken passes through the drinking-water absorption, can reach the purpose of rapid onset.
The specific embodiment
Embodiment 1: 2 parts of Cortex Mori, 2 parts of the Rhizoma Anemarrhenaes, 2 parts of Semen Armeniacae Amarums, 2 parts of Radix Peucedanis, 3 parts of Gypsum Fibrosum, 3 parts of Fructus Forsythiaes, 1 part of Folium Eriobotryae, Pumex 1-part, 1 part in Radix Glycyrrhizae, tangerine 2 parts, 3 parts of Radix Scutellariaes.Decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.02 (80 ℃), and cold preservation 24 hours filters, and filtrate adds sodium benzoate, stirs evenly, packing, promptly.
Be mainly used to symptoms such as throat's swelling that acute and chronic respiratory tract diseases such as infectious bronchitis, laryngotracheitis, mycoplasma infection cause, cough with asthma, mouth breathing, respiratory tract rale.The use of respiratory tract disease initial stage can make symptom rapidly disappear, and no longer recurrence; Respiratory tract disease cooperates the antibacterials use that mortality rate is reduced rapidly late period.Mix drink: per 1 premium on currency adds 1.25 milliliters of this product, every day 1 time, logotype 3-5 days; The serious symptom doubled amount is used.
Embodiment 2: 3.5 parts of Cortex Mori, 3 parts of the Rhizoma Anemarrhenaes, 3 parts of Semen Armeniacae Amarums, 3.5 parts of Radix Peucedanis, 5 parts of Gypsum Fibrosum, 5 parts of Fructus Forsythiaes, 2 parts of Folium Eriobotryaes, 2 parts of Pumexs, 2 parts in Radix Glycyrrhizae, tangerine 3.5 parts, 5 parts of Radix Scutellariaes.Decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.02 (80 ℃), and cold preservation 24 hours filters, and filtrate adds sodium benzoate, stirs evenly, packing, promptly.
Be mainly used to symptoms such as throat's swelling that acute and chronic respiratory tract diseases such as infectious bronchitis, laryngotracheitis, mycoplasma infection cause, cough with asthma, mouth breathing, respiratory tract rale.The use of respiratory tract disease initial stage can make symptom rapidly disappear, and no longer recurrence; Respiratory tract disease cooperates the antibacterials use that mortality rate is reduced rapidly late period.Mix drink: per 1 premium on currency adds 1.25 milliliters of this product, every day 1 time, logotype 3-5 days; The serious symptom doubled amount is used.
Embodiment 3: 5 parts of Cortex Mori, 4 parts of the Rhizoma Anemarrhenaes, 4 parts of Semen Armeniacae Amarums, 5 parts of Radix Peucedanis, 7 parts of Gypsum Fibrosum, 7 parts of Fructus Forsythiaes, 3 parts of Folium Eriobotryaes, 3 parts of Pumexs, 3 parts in Radix Glycyrrhizae, tangerine 5 parts, 7 parts of Radix Scutellariaes.Decoct with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, the filtrate decompression thin film evaporation, and being concentrated into relative density is the clear paste of 1.02 (80 ℃), and cold preservation 24 hours filters, and filtrate adds sodium benzoate, stirs evenly, packing, promptly.
Be mainly used to symptoms such as throat's swelling that acute and chronic respiratory tract diseases such as infectious bronchitis, laryngotracheitis, mycoplasma infection cause, cough with asthma, mouth breathing, respiratory tract rale.The use of respiratory tract disease initial stage can make symptom rapidly disappear, and no longer recurrence; Respiratory tract disease cooperates the antibacterials use that mortality rate is reduced rapidly late period.Mix drink: per 1 premium on currency adds 1.25 milliliters of this product, every day 1 time, logotype 3-5 days; The serious symptom doubled amount is used.
Claims (3)
1. the Chinese medicine preparation with heat-clearing and toxic substances removing, clearing away lung-heat to relieve cough effect is characterized in that: Cortex Mori 2-5 part, Rhizoma Anemarrhenae 2-4 part, Semen Armeniacae Amarum 2-4 part, Radix Peucedani 2-5 part, Gypsum Fibrosum 3-7 part, Fructus Forsythiae 3-7 part, Folium Eriobotryae 1-3 part, Pumex 1-3 part, Radix Glycyrrhizae 1-3 part, tangerine 2-5 part, Radix Scutellariae 3-7 part.
2. a kind of Chinese medicine preparation according to claim 1 with heat-clearing and toxic substances removing, clearing away lung-heat to relieve cough effect, it is characterized in that optimizing prescriptions of the present invention is: 3.5 parts of Cortex Mori, 3 parts of the Rhizoma Anemarrhenaes, 3 parts of Semen Armeniacae Amarums, 3.5 parts of Radix Peucedanis, 5 parts of Gypsum Fibrosum, 5 parts of Fructus Forsythiaes, 2 parts of Folium Eriobotryaes, 2 parts of Pumexs, 2 parts in Radix Glycyrrhizae, tangerine 3.5 parts, 5 parts of Radix Scutellariaes.
3. a kind of Chinese medicine preparation with heat-clearing and toxic substances removing, clearing away lung-heat to relieve cough effect according to claim 1, it is characterized in that: the dosage form of described Chinese medicine preparation is an oral liquid.
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| CNA2006101305318A CN101209329A (en) | 2006-12-25 | 2006-12-25 | Chinese medicinal oral liquid with heat-clearing and detoxication, lung-heat-clearing and cough-relieving efficacy |
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| CNA2006101305318A CN101209329A (en) | 2006-12-25 | 2006-12-25 | Chinese medicinal oral liquid with heat-clearing and detoxication, lung-heat-clearing and cough-relieving efficacy |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417806A (en) * | 2013-08-09 | 2013-12-04 | 山西双鹰动物药业有限公司 | Medicine for treating infectious bronchitis of chicken and preparation method thereof |
| CN104688920A (en) * | 2013-12-05 | 2015-06-10 | 天津嘉瑞生物科技有限公司 | Traditional Chinese medicine oral liquid for preventing and treating bronchitis of dogs and cats and preparation method of traditional Chinese medicine oral liquid |
| CN105194320A (en) * | 2015-11-10 | 2015-12-30 | 周红梅 | Traditional Chinese medicine composition for treating infantile chronic cough |
| CN108785506A (en) * | 2018-09-26 | 2018-11-13 | 四川兴华药业有限责任公司 | It is a kind of to treat snorting compound rhizoma anemarrhenae oral liquid of livestock and poultry cough and preparation method thereof |
-
2006
- 2006-12-25 CN CNA2006101305318A patent/CN101209329A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417806A (en) * | 2013-08-09 | 2013-12-04 | 山西双鹰动物药业有限公司 | Medicine for treating infectious bronchitis of chicken and preparation method thereof |
| CN104688920A (en) * | 2013-12-05 | 2015-06-10 | 天津嘉瑞生物科技有限公司 | Traditional Chinese medicine oral liquid for preventing and treating bronchitis of dogs and cats and preparation method of traditional Chinese medicine oral liquid |
| CN105194320A (en) * | 2015-11-10 | 2015-12-30 | 周红梅 | Traditional Chinese medicine composition for treating infantile chronic cough |
| CN108785506A (en) * | 2018-09-26 | 2018-11-13 | 四川兴华药业有限责任公司 | It is a kind of to treat snorting compound rhizoma anemarrhenae oral liquid of livestock and poultry cough and preparation method thereof |
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Open date: 20080702 |