CN108524746A - A kind of Chinese medicine composition of prevention fowl cough - Google Patents
A kind of Chinese medicine composition of prevention fowl cough Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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Abstract
The invention discloses a kind of Chinese medicine composition of prevention fowl cough, raw material group becomes：8 12 parts of dandelion, 8 12 parts of radix paeoniae rubra, 15 25 parts of cordate houttuynia, 15 25 parts of Rhizoma Atractylodis Macrocephalae, 10 20 parts of Poria cocos, 8 12 parts of Chinese violet, 15 25 parts of Radix Isatidis, 10 20 parts of Fructus Forsythiae, 5 15 parts of rhizoma anemarrhenae, 10 20 parts of the bark of ash, 10 20 parts of pueraria lobata, 8 12 parts of Radix Glycyrrhizae.The present invention is using kinds of traditional Chinese medicines and is re-dubbed compound preparation after Special Mixed extraction process and has unique effects, can promote poultry body healthy tendency itself, improves the ability of the anti-evil disease of body；Also have the effect of anti-inflammatory, sterilization, antiviral, antiallergic action simultaneously, the immunity of poultry can be enhanced, impaired mucous membrane is repaired, effectively control secondary infection.Each bulk pharmaceutical chemicals are mutually coordinated in the Chinese medicine composition of the present invention can play drug effect to the greatest extent together, and clinic proves that Chinese medicine composition of the invention all has extraordinary therapeutic effect to poultry anemofrigid cold and anemopyretic cold.
Description
Technical field
The present invention relates to pharmaceutical technology fields, and in particular to a kind of Chinese medicine composition of prevention fowl cough.
Background technology
Fowl cough is to feel wind, cold, dry, heat, wet, fiery (temperature, heat) again under the conditions of poultry body healthy tendency itself is insufficient
Or a kind of evil and cause exterior syndrome of epidemic disease poison.It is usually unfavorable in climate change, immunity inoculation, feed quality and feeding management difference etc.
Under the conditions of fall ill, be poultry respiratory common disease, be easy concurrent or secondary infection bacteriosis, serious consequence can be caused,
As one of the principal disease of influence poultry production benefit.
Fowl cough is divided into anemofrigid cold and anemopyretic cold by Chinese veterinarian's theory, wherein anemofrigid cold be mainly in winter and
Autumn and winter in alternate season symptoms include the fever of poultry top, lower limb coldness, aversion to cold foul wind, spirit is depressed, moves unsmooth, respiratory tract disease
The state of mind is particularly depressed when shape oppressiveness, wherein morning and low dusk temperature；Due to impairment of yang, initial stage mostly not thirsty not greedy water,
Feed intake declines unobvious, and it is bright to can be seen tracheae to fowl dissect of dying of illness, and only has a small amount of just blood, how bright-coloured, tracheae in crotch
Intracavitary has a little transparent foam sample secretion, may cause Kidney infectious bronchitis etc..Anemopyretic cold is mainly in summer and summer and autumn hands over
For season symptoms include the fever of poultry whole body without aversion to cold, human body compares stretching, extension, and because of its impairment of yin, initial stage amount of drinking water increases, and suffers from fowl multilist
It is now dewatering symptom, feed intake declines after the general 1-2d that falls ill；Downright bad, dry, the first blood of tracheae, official can be seen to fowl dissect of dying of illness
Luminal sectetion is sticky or even yellow, and mycoplasma and colibacillosis etc., death and culling rate can be caused high.
Since flu is divided into chill, anemopyretic, therefore its therapy is different, the drug of anemofrigid cold pungent-warm, is lost as chaste tree is anti-
Poison dissipates；Anemopyretic cold drug cool in nature, such as Shuanghuanglian oral liquid make its heat evil reduce or excrete.Such as to chill disease,
The medicine of a cold nature is misapplied, poultry body yang-energy is easily injured；And applying heat agent is missed to wind-heat person, then consume body fluid or even secondary Other diseases.Cause
This, diagnosis and treatment based on an overall analysis of the illness and the patient's condition is generally required using Chinese veterinarian's medicine prevention fowl cough, few to poultry anemofrigid cold and wind-heat sense at present
Emit the report for the drug for all having therapeutic effect.
Invention content
For the above-mentioned prior art, inventor combines itself clinical experience for many years, therefrom veterinary drug treatment anemofrigid cold and
The rules for the treatment of of anemopyretic cold are set out, through development innovation and development test, by dandelion, radix paeoniae rubra, cordate houttuynia, Rhizoma Atractylodis Macrocephalae, Poria cocos, pale reddish brown
Fourth, Radix Isatidis, Fructus Forsythiae, rhizoma anemarrhenae, the bark of ash, pueraria lobata, 12 taste bulk pharmaceutical chemicals of Radix Glycyrrhizae have been made a kind of to poultry wind through suitable processing
Cold flu and anemopyretic cold all have the Chinese medicine composition of therapeutic effect.
To achieve the above object, the present invention adopts the following technical scheme that：
First aspect present invention, provides a kind of Chinese medicine composition of prevention fowl cough, and raw material group becomes：
It is 8-12 parts of dandelion, 8-12 parts of radix paeoniae rubra, 15-25 parts of cordate houttuynia, 15-25 parts of Rhizoma Atractylodis Macrocephalae, 10-20 parts of Poria cocos, pale reddish brown
8-12 parts of fourth, 15-25 parts of Radix Isatidis, 10-20 parts of Fructus Forsythiae, 5-15 parts of rhizoma anemarrhenae, 10-20 parts of the bark of ash, 10-20 parts of pueraria lobata, Radix Glycyrrhizae 8-
12 parts.
In a preferred embodiment, the raw material group of the Chinese medicine composition becomes：
10 parts of dandelion, 10 parts of radix paeoniae rubra, 20 parts of cordate houttuynia, 20 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Poria cocos, 10 parts of Chinese violet, Radix Isatidis
20 parts, 15 parts of Fructus Forsythiae, 10 parts of rhizoma anemarrhenae, 15 parts of the bark of ash, 15 parts of pueraria lobata, 10 parts of Radix Glycyrrhizae.
The compatibility of Chinese medicine be particular about mutual reinforcement between, mutually make, mutual restraint between two drugs, the mutual-detoxication, the mutual inhibition, conversely, because existing not between different Chinese medicine
With compatibility relationship, therefore when using two tastes above Chinese medicine, it is necessary to be allowed a choice, give full play to what mutual reinforcement between drug mutually made
Compatibility relationship makes the clinical effectiveness of product be significantly improved.
In the Chinese medicine composition of the prevention fowl cough of the present invention, each raw material component is an organic whole, lacks one not
It can.Inventor has found in R＆D process, reduces any one of above-mentioned composition raw material components, or with similar pharmacological property
Bulk pharmaceutical chemicals the raw material components of Chinese medicine composition of the present invention are replaced, then the function and effect of Chinese medicine composition entirety significantly drop
It is low；Other raw material components are further added by the basis of the Chinese medicine composition of the present invention, the overall effect of Chinese medicine composition is not
It improves significantly, or even there is the case where overall effect of Chinese medicine composition reduces to occur.
Each raw material can be crushed, be made after mixing by the above-mentioned preparation for preventing the Chinese medicine composition of fowl cough
With；Or it adds water to cook；Or it is prepared according to other methods.
In a preferred embodiment in accordance with this invention, the preparation method of the Chinese medicine composition of above-mentioned prevention fowl cough
For：
(1) it is mixed after crushing dandelion and radix paeoniae rubra, the water of 10-15 times of weight is added, be heated to 70-90 DEG C, heat preservation leaching
1-2h is carried, is extracted 2-3 times, filtering discards filter residue, merging filtrate；After filtrate coarse filtration molecule is isolated with the method for UF membrane again
The effective part group between 5000-15000 is measured, extract A is obtained；
(2) it is mixed after crushing Chinese violet, rhizoma anemarrhenae and the bark of ash, through supercritical CO2Extraction, extracting pressure 25-
30MPa, 30-40 DEG C of extraction temperature, extraction time 2-4h, entrainer are 95% (volume fraction) ethyl alcohol, and entrainer dosage is
The 8-12% of raw material gross weight, obtains extract B；
(3) it is mixed after crushing cordate houttuynia, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Isatidis, Fructus Forsythiae, pueraria lobata and Radix Glycyrrhizae, 8-12 times of weight is added
Water, decoct 2-4 time, merging decoction liquor, obtain extract C；
(4) extract A, extract B and extract C are mixed, it is dry to get.
Preferably, dry using freeze-drying in step (4).
Traditional Chinese medicine ingredients are complicated, existing water soluble ingredient in a kind of medicinal material, and have oil-soluble or Alcohol soluble composition, difference extraction
The pharmacological activity at position is different, and some active constituents are easy inactivation at high temperature, therefore by selecting suitable extracting method
Separation is extracted to effective component of chinese medicine with extraction process, can extract to greatest extent active ingredient and ensure effectively at
The activity divided, to ensure the clinical effectiveness of product.In addition, plurality of Chinese is subjected to mixing extraction using suitable method, it can
It can increase the solubility of effective ingredient, eliminate or weaken the toxicity of some drugs, and generate novel substance, play new
Curative effect acts on.
Experiment proves that using currently preferred preparation method, the bulk pharmaceutical chemicals in Chinese medicine composition are classified and used
Different extracting methods carries out mixing extraction, and the active ingredient and guarantee that can be extracted to greatest extent in Chinese medicine composition have
The activity of ingredient is imitated, invalid even harmful ingredient is removed, to ensure the clinical effectiveness of product.
Application of the above-mentioned Chinese medicine composition in the feed addictive for preparing prevention fowl cough is also the protection of the present invention
Range.
In the application, concrete application method is：Per 1g Chinese medicine composition spice 500g, it is used in conjunction 3-5 days.
The present invention also protects application of the above-mentioned Chinese medicine composition in the pharmaceutical preparation for preparing prevention fowl cough.
Third aspect present invention provides a kind of pharmaceutical preparation of prevention fowl cough, by above-mentioned Chinese medicine composition and pharmacy
Upper acceptable auxiliary material is prepared.
Various pharmaceutical dosage forms can be made in said medicine preparation, such as powder, pulvis, solution, soluble powder or injection.
The pharmaceutically acceptable auxiliary material is the veterinary drug auxiliary material of routine, such as：Sweetener, disintegrant, lubricant, binder
Deng.It is preferably one or more in cyclodextrin, starch, sodium carboxymethylcellulose, maltodextrin.
Beneficial effects of the present invention：
The present invention is knot on the basis of carrying out numerous studies to clinically multiple poultry anemofrigid cold and anemopyretic cold
The pharmacodynamic profile for closing Chinese medicine and effective component of chinese medicine, pathogenic factor is considered comprehensively, has Chinese medicine using multi-flavor and through Special Mixed
It is re-dubbed compound preparation after extraction process and has unique effects, poultry body healthy tendency itself can be promoted, improves the anti-heresy of body
The ability of disease；Also have the effect of anti-inflammatory, sterilization, antiviral, antiallergic action simultaneously, the immunity of poultry can be enhanced, repaiied
It is damaged mucous membrane again, effectively controls secondary infection.Each bulk pharmaceutical chemicals are mutually coordinated in the Chinese medicine composition of the present invention together can be most
The performance drug effect of big degree, clinic prove that Chinese medicine composition of the invention all has poultry anemofrigid cold and anemopyretic cold non-
Often good therapeutic effect.
Specific implementation mode
It is noted that following detailed description is all illustrative, it is intended to provide further instruction to the application.Unless another
It indicates, all technical and scientific terms used herein has usual with the application person of an ordinary skill in the technical field
The identical meanings of understanding.
As background technology part is introduced, due to Chinese veterinarian for poultry anemofrigid cold and anemopyretic cold therapy,
The rules for the treatment of are different, it is difficult to realize a prescription object while have therapeutic effect to anemofrigid cold and anemopyretic cold.To solve this problem,
The present invention is analyzed comprehensively by the pathogenic factor, therapy, the rules for the treatment of to poultry anemofrigid cold and anemopyretic cold, and a large amount of
A kind of clinical practice, it is proposed that Chinese medicine composition of new prevention fowl cough.
Theory of traditional Chinese medical science thinks that hundreds of diseases resulting from disorder, gas gives birth to all kinds of diseases and ailments, varied, sum up nothing more than " gas discord " and
" gas is obstructed ".Gas is got along well, including unsaturated vapor is gentle has a surplus；Gas is obstructed, including the stagnation of the circulation of vital energy and the circulation of vital energy in the wrong direction.Unsaturated vapor is to lead to fowl cough
Most basic reason, thus the present invention starts with, to promote poultry body healthy tendency itself as mainly at square thinking, meanwhile, selecting
When selecting bulk pharmaceutical chemicals based on warm nature drug, make after each bulk pharmaceutical chemicals Cheng Fang can warm but not dry, profit and oiliness, cold dispelling without helping
Heat, inducing diaphoresis all have therapeutic effect without hindering just to poultry anemofrigid cold and anemopyretic cold.
Traditional Chinese medicine ingredients are complicated, for Chinese medicine compound prescription, drug effect reach be by multiple active ingredients it
Between interaction realize.Same bulk pharmaceutical chemicals use the active ingredient that Different Extraction Method obtains, drug effect often to deposit
In difference.To further increase the whole curative effect of the Chinese medicine composition for preventing fowl cough of the invention, the present invention is to the Chinese medicine
Bulk pharmaceutical chemicals in composition are respectively adopted different methods and extract, to remove invalid impurity as far as possible with pure preparations,
The synergistic function between different extracts is played simultaneously.It verifies and finds through test of many times, add water to carry dandelion and radix paeoniae rubra
It takes, using effective part group of the molecular weight between 5000-15000 as active ingredient；Chinese violet, rhizoma anemarrhenae and the bark of ash are used
Supercritical CO2Extraction, obtains active ingredient；Cordate houttuynia, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Isatidis, Fructus Forsythiae, pueraria lobata and Radix Glycyrrhizae are used into decocting
Extraction is boiled, active ingredient is obtained；These three active ingredients are remixed, prevention fowl cough can be played to the greatest extent in this way
Effect.
In order to enable those skilled in the art can clearly understand the technical solution of the application, below with reference to tool
The technical solution of the application is described in detail in the embodiment of body.
Test material used in the embodiment of the present invention and comparative example is the test material of this field routine, can be passed through
Commercial channel is commercially available.
Embodiment 1：
1. bulk pharmaceutical chemicals form：
10 grams of dandelion, 10 grams of radix paeoniae rubra, 20 grams of cordate houttuynia, 20 grams of Rhizoma Atractylodis Macrocephalae, 15 grams of Poria cocos, 10 grams of Chinese violet, Radix Isatidis
20 grams, 15 grams of Fructus Forsythiae, 10 grams of rhizoma anemarrhenae, 15 grams of the bark of ash, 15 grams of pueraria lobata, 10 grams of Radix Glycyrrhizae.
2. preparation method：
(1) will dandelion and radix paeoniae rubra crush after mix, the water of 12 times of weight is added, and (i.e. the addition of water is dandelion and red
12 times of weight of Chinese herbaceous peony), 80 DEG C are heated to, heat preservation extraction 2h is extracted 2 times, and filtering discards filter residue, merging filtrate；After filtrate coarse filtration
Effective part group of the molecular weight between 5000-15000 is isolated with the method for UF membrane again, obtains extract A；
(2) it is mixed after crushing Chinese violet, rhizoma anemarrhenae and the bark of ash, through supercritical CO2Extraction, extracting pressure 28MPa, extraction
It is 95% (volume fraction) ethyl alcohol to take 35 DEG C, extraction time 3h of temperature, entrainer, and entrainer dosage is raw material gross weight
10% (i.e. the addition of entrainer be Chinese violet, rhizoma anemarrhenae and bark of ash total weight 10%), obtain extract B；
(3) it is mixed after crushing cordate houttuynia, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Isatidis, Fructus Forsythiae, pueraria lobata and Radix Glycyrrhizae, 10 times of weight is added
Water decocts 3 times, merges decoction liquor, obtains extract C；
(4) extract A, extract B and extract C are mixed, is freeze-dried to get the Chinese medicine of prevention poultry anemofrigid cold
Composition.
Embodiment 2：
Bulk pharmaceutical chemicals form：
8 grams of dandelion, 12 grams of radix paeoniae rubra, 15 grams of cordate houttuynia, 25 grams of Rhizoma Atractylodis Macrocephalae, 10 grams of Poria cocos, 12 grams of Chinese violet, Radix Isatidis 15
Gram, 20 grams of Fructus Forsythiae, 5 grams of rhizoma anemarrhenae, 20 grams of the bark of ash, 10 grams of pueraria lobata, 12 grams of Radix Glycyrrhizae.
The preparation method is the same as that of Example 1.
Embodiment 3：
Bulk pharmaceutical chemicals form：
12 grams of dandelion, 8 grams of radix paeoniae rubra, 25 grams of cordate houttuynia, 15 grams of Rhizoma Atractylodis Macrocephalae, 20 grams of Poria cocos, 8 grams of Chinese violet, Radix Isatidis 25
Gram, 10 grams of Fructus Forsythiae, 15 grams of rhizoma anemarrhenae, 10 grams of the bark of ash, 20 grams of pueraria lobata, 8 grams of Radix Glycyrrhizae.
The preparation method is the same as that of Example 1.
Comparative example 1：
The present invention has carried out the multi-flavor bulk pharmaceutical chemicals with close pharmacological property in R＆D process investigation and the medicine of compatibility relationship
The research of effect, as a result, it has been found that, even if the pharmacological property between a few taste bulk pharmaceutical chemicals is similar, but the bulk pharmaceutical chemicals compatible use different from other
Afterwards, effect significant difference.Such as：By in the pharmaceutical formulation of embodiment 1 bulk pharmaceutical chemicals component dandelion and radix paeoniae rubra replace
For honeysuckle and the root of Dahurain angelica, remaining bulk pharmaceutical chemicals is the same as embodiment 1；
It prepares with the following method：
(1) it is mixed after crushing honeysuckle and the root of Dahurain angelica, the water of 12 times of weight is added, be heated to 80 DEG C, heat preservation extraction 2h is carried
It takes 2 times, filters, discard filter residue, merging filtrate；Molecular weight is isolated in 5000- with the method for UF membrane again after filtrate coarse filtration
Effective part group between 15000, obtains extract A；
(2) it is mixed after crushing Chinese violet, rhizoma anemarrhenae and the bark of ash, through supercritical CO2Extraction, extracting pressure 28MPa, extraction
It is 95% (volume fraction) ethyl alcohol to take 35 DEG C, extraction time 3h of temperature, entrainer, and entrainer dosage is raw material gross weight
10%, obtain extract B；
(3) it is mixed after crushing cordate houttuynia, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Isatidis, Fructus Forsythiae, pueraria lobata and Radix Glycyrrhizae, 10 times of weight is added
Water decocts 3 times, merges decoction liquor, obtains extract C；
(4) extract A, extract B and extract C are mixed, freeze-drying obtains Chinese medicine composition A.
Comparative example 2：
The present invention has also carried out plus-minus optimization to the bulk pharmaceutical chemicals composition type in prescription in R＆D process and has investigated.Such as：
Radix paeoniae rubra, rhizoma anemarrhenae and the bark of ash in the medicament composing prescription of embodiment 1 is omitted, remaining makes as described in Example 1 with embodiment 1
For at Chinese medicine composition B.
For another example 3 taste bulk pharmaceutical chemicals of reed root, chrysanthemum and spina date seed are further added by the basis of the medicament composing prescription of embodiment 1, it is former
Expect the dosage of medicine with reference to the dosage in pharmacopeia, water decoction processing is carried out together with the 7 taste medicines such as this increased 3 taste medicine and cordate houttuynia, and
It is prepared into Chinese medicine composition C as described in Example 1.
Comparative example 3：
The dose of each bulk pharmaceutical chemicals is the mark efficacy of a drug in Chinese medicine composition, even if the drug composition of prescription is identical, if but medicine
The dosage of object is different, and the efficacy of a drug is then divided into size, compatibility relationship then to have the change of monarch, to which its work(cures mainly then respectively
It is different.The present invention has carried out grinding for investigation and drug effect in R＆D process to the content of each raw material in Chinese medicine composition
Study carefully, as a result, it has been found that, inappropriate raw material proportioning relationship, effect significant difference.Such as：By dandelion in embodiment 1, white
Art, Chinese violet, Fructus Forsythiae parts by weight double, the parts by weight of radix paeoniae rubra, rhizoma anemarrhenae and the bark of ash are halved；The dosage of other raw materials is the same as real
Example 1 is applied, and is prepared into Chinese medicine composition D as described in Example 1.
Comparative example 4：
The ingredient of Chinese medicine is sufficiently complex, not only contains plurality of active ingredients, but also have invalid components, is also free of toxic component, adopts
There are significant differences for the drug effect of the compound Chinese medicinal preparation differently prepared.The present invention is in R＆D process also to Chinese traditional medicine composition
The preparation method of object is studied, as a result, it has been found that, Chinese medicine composition prepared by distinct methods, even if Chinese medicine composition is used
Bulk pharmaceutical chemicals it is consistent, but the effect significant difference of Chinese medicine composition.For example, by the system of the Chinese medicine composition in embodiment 1
Preparation Method is adjusted to：Each bulk pharmaceutical chemicals are weighed by weight, are mixed after crushing, the water of 10 times of weight is added, are decocted 3 times, are merged and are decocted
Boil liquid concentrates, dry, is prepared into Chinese medicine composition E.
Test example 1：Security test of the Chinese medicine composition to chicken embryo
Chinese medicine composition prepared by embodiment 1-3 is configured to sterile saline to the solution of a concentration of 1g/ml respectively,
It is measured using the method for chick embryo allantoic cavity inoculated composition.It is specific as follows：
Chinese medicine composition is carried out to 1,5,10,50,100 times of dilution respectively with physiological saline, by 0.2ml/ dosage only point
The SPF chick embryo allantois intracavitary for not injecting 9 ages in days, is put in 37 DEG C of constant incubators and is incubated, and interval 12h is injected 1 time, every group 10 again
Piece chicken embryo, continues to be incubated, and observes the state of chicken embryo daily, dead chicken embryo in for 24 hours is discarded, the chicken embryo of 25-72h death is timely
It takes out, after being put into 4 DEG C of refrigerator freezing 6h, chick embryo development and death state is dissected and observed.Embryo living continues hatching until hatching.With right
Non-lethal maximum concentration is minimum lethal concentration (MLC) to chicken embryo safely, determines Chinese medicine composition to chicken embryo according to minimum lethal concentration (MLC)
Safety.
As a result, it has been found that Chinese medicine composition prepared by inoculation embodiment 1-3, inoculated into chick embryo is zero death, therefore, the present invention
Chinese medicine composition be safe to chicken embryo.
Test example 2：
Chinese medicine composition prepared by embodiment 1 and comparative example 1-4 is configured to a concentration of 1mg/ml's with sterile water respectively
Solution.
By 2 × 102EID50Strains of influenza viruses be seeded to 9 age in days SPF chicken embryos, per embryonic breeding kind 0.1ml, blank control group connects
Kind sterile saline, 37 DEG C hatch 4 hours, are then inoculated with the solution of above-mentioned preparation respectively, and test group is inoculated in embodiment 1
The solution that drug composition is configured to, control 5 groups of 1 group-control be inoculated with respectively Chinese medicine composition A- Chinese medicine compositions E be configured to it is molten
Liquid, per embryonic breeding kind 0.1ml；Attack the sterile saline of malicious control group inoculation equivalent；37 DEG C of hatchings discard dead chicken embryo in for 24 hours,
It is later primary every 6 hours photograph eggs, it observes 5 days altogether, observes and records the time of dead chicken embryo every time, statistics each group is to chicken embryo
Protective rate.Test result is shown in Table 1.
Table 1：Each group SPF chicken embryo death situations
| Group | Dead germ number | Embryo number living | The death rate (%) | Protective rate (%) |
| Blank control group | 0 | 20 | 0 | 100 |
| Attack malicious control group | 18 | 2 | 90 | - |
| Test group | 0 | 10 | 0 | 100 |
| Compare 1 group | 6 | 14 | 30 | 70 |
| Compare 2 groups | 4 | 16 | 20 | 80 |
| Compare 3 groups | 5 | 15 | 25 | 75 |
| Compare 4 groups | 8 | 12 | 40 | 60 |
| Compare 5 groups | 10 | 10 | 50 | 50 |
As can be seen from Table 1, protection of the Chinese medicine composition of the embodiment of the present invention 1 to the SPF chicken embryos of influenza virus infection
Effect will be significantly better than comparative example 1 (Chinese medicine composition A).Illustrate that the composition of the present invention meets the compatibility relationship of Chinese medicine, each group
/ have collaboration facilitation, be not simple replacement and the combination of the bulk pharmaceutical chemicals with similar pharmacological property.
The Chinese medicine composition prepared by embodiment 1 compare with Chinese medicine composition B-D it can be seen from embodiment 1 medicine
On the basis of object prescription, no matter it is further added by the type of bulk pharmaceutical chemicals or reduces the type of bulk pharmaceutical chemicals, or the Chinese medicine group of adjustment embodiment 1
The dosage for closing each bulk pharmaceutical chemicals in object, can all reduce its protecting effect to the SPF chicken embryos of influenza virus infection.
The Chinese medicine composition prepared by embodiment 1 compare with Chinese medicine composition E it can be seen from preparation method to preparation
The drug effect of Chinese medicine composition has the function of very crucial, and Chinese medicine composition prepared by preparation method using the present invention can be shown
Write the protecting effect improved to the SPF chicken embryos of influenza virus infection.
Test example 3：
In order to verify Chinese medicine composition of the invention to the therapeutic effect of poultry anemofrigid cold, we choose in certain chicken farm
The chicken that anemofrigid cold occurs is tested.
1. test method：
400 chicken (symptoms of anemofrigid cold will occur：The fever of poultry top, lower limb coldness, aversion to cold foul wind, spirit it is depressed,
Move that unsmooth, respiratory symptom is dull, wherein morning and the state of mind is particularly depressed when low dusk temperature), stochastic averagina
It is divided into 1 group of experiment, 2 groups of experiment, experiment 3 groups and control group, wherein 3 groups of 1 group-experiment of experiment is taken embodiment 1-3 and prepared respectively
Chinese medicine composition, taken by every 1g spices 500g；Control group takes commercially available Antiphlogistic Powder of Schizonepetae and Ledebouriellae, and by specification is taken
With.The above each group is used in conjunction 3 days.
2. curative effect determinate standard：
It cures：Chicken it is in high spirits, appetite is good, and lower limb temperature recovery is normal, coughs, sneezes, getting rid of symptom and disappear；
Effectively：The above symptom is relieved, and spirit improves, and appetite is preferable, occasionally has cough, sneezes, gets rid of a symptom；
In vain：The above symptom is without being clearly better, some even aggravations.
3. test result：
Test result is shown in Table 2.
Table 2：To the therapeutic effect of anemofrigid cold
| Group | Chicken quantity (only) | Efficient (%) | Cure rate (%) | Inefficiency (%) |
| Test 1 group | 100 | 98 | 92 | 2 |
| Test 2 groups | 100 | 94 | 88 | 6 |
| Test 3 groups | 100 | 95 | 85 | 5 |
| Control group | 100 | 84 | 72 | 16 |
During experiment, 2 groups of 1 group of experiment and experiment do not occur chicken death, and 3 groups of chicken death rates of experiment are 1%,
The control group chicken death rate is 5%.
Test example 4：
In order to verify Chinese medicine composition of the invention to the therapeutic effect of poultry anemopyretic cold, we choose in certain chicken farm
The chicken that anemopyretic cold occurs is tested.
1. test method：
400 chicken (symptoms of anemopyretic cold will occur：Poultry whole body generates heat without aversion to cold, and human body compares stretching, extension, because of its wound
The moon, initial stage amount of drinking water increase, and suffer from fowl and show as dewatering symptom more, and feed intake declines after the general 1-2d that falls ill), stochastic averagina is divided into
It tests 1 group, 2 groups of experiment, test 3 groups and control group, wherein 3 groups of 1 group-experiment of experiment is taken respectively in embodiment 1-3 preparations
Drug composition is taken by every 1g spices 500g；Control group takes commercially available Shuanghuanglian oral liquid, and by specification is taken.
The above each group is used in conjunction 3 days.
2. curative effect determinate standard：
It cures：Chicken it is in high spirits, appetite is good, and temperature recovery is normal, and drinking-water restores normal, coughs, sneezes, getting rid of a symptom
It disappears；
Effectively：The above symptom is relieved, and spirit improves, and appetite is preferable, occasionally has cough, sneezes, gets rid of a symptom；
In vain：The above symptom is without being clearly better, some even aggravations.
3. test result：
Test result is shown in Table 3.
Table 3：To the therapeutic effect of anemopyretic cold
| Group | Chicken quantity (only) | Efficient (%) | Cure rate (%) | Inefficiency (%) |
| Test 1 group | 100 | 97 | 90 | 3 |
| Test 2 groups | 100 | 92 | 84 | 8 |
| Test 3 groups | 100 | 90 | 81 | 10 |
| Control group | 100 | 82 | 75 | 18 |
During experiment, 1 group of experiment does not occur chicken death, and 3 groups of chicken death rates of 2 groups of experiment and experiment are 1%, right
It is 4% according to group chicken death rate.
The foregoing is merely the preferred embodiments of the application, are not intended to limit this application, for the skill of this field
For art personnel, the application can have various modifications and variations.Within the spirit and principles of this application, any made by repair
Change, equivalent replacement, improvement etc., should be included within the protection domain of the application.
Claims (9)
1. a kind of Chinese medicine composition of prevention fowl cough, which is characterized in that its raw material group becomes：
8-12 parts of dandelion, 8-12 parts of radix paeoniae rubra, 15-25 parts of cordate houttuynia, 15-25 parts of Rhizoma Atractylodis Macrocephalae, 10-20 parts of Poria cocos, Chinese violet 8-
12 parts, 15-25 parts of Radix Isatidis, 10-20 parts of Fructus Forsythiae, 5-15 parts of rhizoma anemarrhenae, 10-20 parts of the bark of ash, 10-20 parts of pueraria lobata, 8-12 parts of Radix Glycyrrhizae.
2. Chinese medicine composition according to claim 1, which is characterized in that its raw material group becomes：
10 parts of dandelion, 10 parts of radix paeoniae rubra, 20 parts of cordate houttuynia, 20 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Poria cocos, 10 parts of Chinese violet, 20 parts of Radix Isatidis,
15 parts of Fructus Forsythiae, 10 parts of rhizoma anemarrhenae, 15 parts of the bark of ash, 15 parts of pueraria lobata, 10 parts of Radix Glycyrrhizae.
3. the preparation method of Chinese medicine composition as claimed in claim 1 or 2, which is characterized in that include the following steps：
(1) it is mixed after crushing dandelion and radix paeoniae rubra, the water of 10-15 times of weight is added, be heated to 70-90 DEG C, heat preservation extraction 1-
2h is extracted 2-3 times, and filtering discards filter residue, merging filtrate；Molecular weight is isolated after filtrate coarse filtration with the method for UF membrane again to exist
Effective part group between 5000-15000, obtains extract A；
(2) it is mixed after crushing Chinese violet, rhizoma anemarrhenae and the bark of ash, through supercritical CO2Extraction, extracting pressure 25-30MPa, extraction
30-40 DEG C of temperature, extraction time 2-4h, entrainer are 95% (volume fraction) ethyl alcohol, and entrainer dosage is raw material gross weight
8-12%, obtain extract B；
(3) it is mixed after crushing cordate houttuynia, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Isatidis, Fructus Forsythiae, pueraria lobata and Radix Glycyrrhizae, 8-12 times of weight is added
Water decocts 2-4 times, merges decoction liquor, obtains extract C；
(4) extract A, extract B and extract C are mixed, it is dry to get.
4. preparation method according to claim 3, which is characterized in that dry using freeze-drying in step (4).
5. application of the Chinese medicine composition as claimed in claim 1 or 2 in the feed addictive for preparing prevention fowl cough.
6. application of the Chinese medicine composition as claimed in claim 1 or 2 in the pharmaceutical preparation for preparing prevention fowl cough.
7. a kind of pharmaceutical preparation of prevention fowl cough, which is characterized in that by Chinese medicine composition as claimed in claim 1 or 2 and
Pharmaceutically acceptable auxiliary material is prepared.
8. pharmaceutical preparation according to claim 7, which is characterized in that the pharmaceutically acceptable auxiliary material be disintegrant,
Lubricant, sweetener or binder.
9. pharmaceutical preparation according to claim 7 or 8, which is characterized in that powder, pulvis, solution, soluble powder or
Injection.
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| CN112057571A (en) * | 2020-10-10 | 2020-12-11 | 浙江大飞龙动物保健品股份有限公司 | Antiviral traditional Chinese medicine soluble powder for improving immunity and preparation process thereof |
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|---|---|---|---|---|
| CN1089149A (en) * | 1993-01-01 | 1994-07-13 | 李仲哲 | " Jiganling "-medicine for treating chicken disease |
| CN104435626A (en) * | 2014-12-17 | 2015-03-25 | 鼎正动物药业（天津）有限公司 | Traditional Chinese medicine oral liquid for treating viral diseases of livestock and poultry and preparation method of traditional Chinese medicine oral liquid |
| CN105613965A (en) * | 2014-10-27 | 2016-06-01 | 张雯 | Chinese herb additive for preparing broiler feed |
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2018
- 2018-06-19 CN CN201810627892.6A patent/CN108524746B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089149A (en) * | 1993-01-01 | 1994-07-13 | 李仲哲 | " Jiganling "-medicine for treating chicken disease |
| CN105613965A (en) * | 2014-10-27 | 2016-06-01 | 张雯 | Chinese herb additive for preparing broiler feed |
| CN104435626A (en) * | 2014-12-17 | 2015-03-25 | 鼎正动物药业（天津）有限公司 | Traditional Chinese medicine oral liquid for treating viral diseases of livestock and poultry and preparation method of traditional Chinese medicine oral liquid |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112057571A (en) * | 2020-10-10 | 2020-12-11 | 浙江大飞龙动物保健品股份有限公司 | Antiviral traditional Chinese medicine soluble powder for improving immunity and preparation process thereof |
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