CN106237070A - A kind of Chinese medicine oral liquid for treating the airsacculitis that chicken mixed infection causes - Google Patents

A kind of Chinese medicine oral liquid for treating the airsacculitis that chicken mixed infection causes Download PDF

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Publication number
CN106237070A
CN106237070A CN201610790626.6A CN201610790626A CN106237070A CN 106237070 A CN106237070 A CN 106237070A CN 201610790626 A CN201610790626 A CN 201610790626A CN 106237070 A CN106237070 A CN 106237070A
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parts
radix
oral liquid
airsacculitis
chicken
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冯静波
叶峰先
周光玉
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Wuxi Zhengda Biology Co Ltd
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Wuxi Zhengda Biology Co Ltd
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Abstract

A kind of Chinese medicine oral liquid for treating the airsacculitis that chicken mixed infection causes, it is characterized in that, be made up of the raw material of following mass fraction: 10 30 parts of Gypsum Fibrosum, 1 10 parts of Herba Ephedrae, Fructus Gardeniae 1 10 parts, Radix Scutellariae 1 10 parts, Fructus Forsythiae 1 10 parts, Flos Lonicerae 1 10 parts, Radix Isatidis 1 10 parts, 1 10 parts of Semen Armeniacae Amarum, Radix Paeoniae Rubra 1 10 parts, Cortex Moutan 18 parts, Radix Platycodonis 1 10 parts, Radix Ophiopogonis 1 10 parts, the Rhizoma Anemarrhenae 1 10 parts, Fructus Trichosanthis 15 parts, 15 parts of Radix Glycyrrhizae.This oral liquid have antiviral, antibacterial, eliminate the phlegm, antiinflammatory action, it is possible to have prevention and effect treatment chicken airsacculitis.

Description

A kind of Chinese medicine oral liquid for treating the airsacculitis that chicken mixed infection causes
Technical field
The present invention relates to poultry technical field of Chinese medicines, especially relate to the Prevention Technique field of chicken airsacculitis.
Background technology
Chicken airsacculitis is simple by escherichia coli, mycoplasma and some pathogenic virus or the disease of mixed infection initiation. Under the conditions of commercialization, the mixed infection that multiple cause of disease causes including virus, antibacterial, mycoplasma, immunosuppressant, adverse environment etc. More more common than Simple infection.Each age in days chicken all can fall ill, in the majority with chickling and middle chicken.Mainly show as disease chicken spirit depressed, Dyspnea, has sound, cough.Cuing open the visible air bag of inspection muddy, have a large amount of muddy transudate, severe one airbag wall thickens, and has big The little cheesy grumeleuse not waited, primary disease sickness rate is high, has a strong impact on the growth performance of chicken, and infects this after being ill, often because of other Secondary infection other diseases.
There are the following problems in the preventing and treating of chicken airsacculitis at present: one is that source of disease factor is complicated, has virus, antibacterial, mycoplasma etc. Mixed infection, can not effectively prevent and treat by vaccine merely.Two is a large amount of uses due to antibiotic and chemistry antibacterials, and cause of disease is micro- Biology creates drug resistance widely, makes therapeutic effect constantly decline, and clinic has to escalated dose and extends administration time, Treatment difficulty and cost are greatly improved；Three are antibiotic and chemicals is formed in the products such as Carnis Gallus domesticus, internal organs and egg Hazard residue, endangers food safety.
Although also there being the report using Chinese herb prevention chicken airsacculitis.But remain at following point: one is to treat air bag at present Scorching Chinese medicine is based on powder preparation formulation, it is impossible to mixed drink is administered, and uses inconvenience at modern intensive feed lot；Two is that majority rests on Prescription level, does not carries out the clinical trial of specification, it is impossible to prove its effectiveness from modern lemology angle；Three is not from the modern times Pharmacological point illustrates its mechanism of action.
Summary of the invention
The problems referred to above existed for prior art, the applicant provides a kind of for treating what chicken mixed infection caused The Chinese medicine oral liquid of airsacculitis.This oral liquid have antiviral, antibacterial, eliminate the phlegm, antiinflammatory action, it is possible to have prevention and effect treatment chicken Airsacculitis.
Technical scheme is as follows:
A kind of Chinese medicine oral liquid for treating the airsacculitis that chicken mixed infection causes, by the raw material system of following mass fraction Become:
Gypsum Fibrosum 10-30 part, Herba Ephedrae 1-10 part, Fructus Gardeniae 1-10 part, Radix Scutellariae 1-10 part, Fructus Forsythiae 1-10 part, Flos Lonicerae 1-10 part, Radix Isatidis 1-10 part, Semen Armeniacae Amarum 1-10 part, Radix Paeoniae Rubra 1-10 part, Cortex Moutan 1-8 part, Radix Platycodonis 1-10 part, 1-10 part Radix Ophiopogonis, Rhizoma Anemarrhenae 1-10 Part, Fructus Trichosanthis 1-5 part, Radix Glycyrrhizae 1-5 part.
The preparation method of a kind of Chinese medicine oral liquid for treating the airsacculitis that chicken mixed infection causes, concrete steps are such as Under:
(1) soak: Flos Lonicerae, Radix Scutellariae soak 2-3 hour by the normal-temperature water of 4-5 times of respective quality respectively；Other raw materials Use 45-50 DEG C of water soaking 2-3 hour respectively；
(2) decoct for the first time: with the soak by water of 8-9 times of all raw material gross masses, water temperature 80-90 DEG C, the time, 2-3 was little Time；First put into other raw materials in addition to Flos Lonicerae, Radix Scutellariae during decoction, decoct and put into Radix Scutellariae constantly to 1.5-2 is little；
(3) second time decocts: uses the soak by water of 6-7 times of all raw material gross masses, and puts into Flos Lonicerae, decocting time 1.5-2 hour；
(4) concentrate: merge the decoction liquor of twice, the extractum that filtering and concentrating becomes relative density to be 1.01-1.04, drip concentration Sodium citrate solution for 3.8-6.0wt% regulates pH to 4.3-6；
(5) adding the sodium benzoate of 4-6wt%, 40-60 DEG C of fill while stirring, oral liquid is made in sterilizing.
When decocting for first and second time, Gypsum Fibrosum need to be with ventilative woven bag parcel.
Useful the having the technical effect that of the present invention
What 1, the present invention provided is pure Chinese medicinal preparation for treating the Chinese medicine oral liquid of the airsacculitis that chicken mixed infection causes, Have antiviral, antibacterial, eliminate the phlegm, antiinflammatory action, it is possible to be used for treating virus, antibacterial, mycoplasma, immunosuppressant, adverse environment The chicken airsacculitis caused etc. the mixed infection of multiple cause of disease initiation.Drug residue, generation is produced with antibiotic therapy chicken airsacculitis Drug resistance compare, safety is obviously improved, definite effect；
2, the Chinese medicine oral liquid for treating the airsacculitis that chicken mixed infection causes that the present invention provides, uses and has heat clearing away Eliminate the phlegm, the Chinese prescription of dispersing swelling and dissipating binds.Formula epheday intermedia is monarch drug, has that it is warm in nature, and acrid in the mouth, micro-hardship have diaphoresis cold expelling, lung qi dispersing Relieving asthma, effect of inducing diuresis to remove edema；Gypsum Fibrosum, Semen Armeniacae Amarum, Radix Ophiopogonis, the Rhizoma Anemarrhenae have clearing away heat-fire, effect of clear eliminating the pathogens from the lung heat, for ministerial drug；Yellow A kind of reed mentioned in ancient books, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Fructus Gardeniae are respectively provided with removing toxic substances removing toxic substances removing heat from blood, effect of pathogenic fire reducing mass dissipating and swelling eliminating, are aided with Radix Platycodonis heat clearing away Reduce phlegm, dissipating depression of QI eliminating stagnation；Radix Glycyrrhizae as making medicine relieving cough and asthma, invigorating the spleen and replenishing QI, in order to treat clinical chicken group busy Lu, pant, cough etc. Symptom；And feces is dried symptom or thin such as symptoms such as water.
3, chicken group busy Lu, pant, the cough initial stage is best opportunity of medication, now body organic lesion is relatively light, many places In the functional disturbance stage, the medication same day or the 2nd day can take effect.Chicken group controls or wrong treatment as lost, and declining occurs in feed intake, dead Start to increase, need positive effect seen from medication 2-3 days.This product usage and consumption: this product 1000ml is watered 600kg, every day uses Once, concentration is drunk.
3, the present invention provide for treating the medicine of chicken airsacculitis, for Chinese medicine oral liquid, with traditional Chinese powder medicine phase Ratio, have easy to use, effect rapidly, bioavailability high.
Detailed description of the invention
Below in conjunction with embodiment and test case, the present invention is specifically described.
Embodiment 1
The applicant provides a kind of Chinese medicine oral liquid for treating the airsacculitis that chicken mixed infection causes, by following matter The raw material of amount number is made:
10 parts of Gypsum Fibrosum, 3 parts of Herba Ephedrae, Fructus Gardeniae 1 part, Radix Scutellariae 1 part, Fructus Forsythiae 1 part, Flos Lonicerae 1 part, Radix Isatidis 1 part, 1 part of Semen Armeniacae Amarum, Radix Paeoniae Rubra 1 part, Cortex Moutan 1 part, Radix Platycodonis 1 part, Radix Ophiopogonis 1 part, the Rhizoma Anemarrhenae 1 part, Fructus Trichosanthis 1 part, 1 part of Radix Glycyrrhizae.
The preparation method of described oral liquid specifically comprises the following steps that
(1) soak: Flos Lonicerae, Radix Scutellariae soak 2 hours by the normal-temperature water of 4 times of respective quality respectively；Other raw materials are respectively With 45 DEG C of water soakings 2 hours；
(2) decoct for the first time: with the soak by water of 8 times of all raw material gross masses, water temperature 80 DEG C, time 2 h；During decoction First putting into other raw materials in addition to Flos Lonicerae, Radix Scutellariae, decoction to 1.5 is little puts into Radix Scutellariae constantly；
(3) second time decocts: with the soak by water of 6 times of all raw material gross masses, and puts into Flos Lonicerae, decocting time 1.5 Hour；
(4) concentrating: merge the decoction liquor of twice, the extractum that filtering and concentrating becomes relative density to be 1.01, dropping concentration is The sodium citrate solution regulation pH to 4.3 of 3.8wt%；
(5) adding the sodium benzoate of 4wt% while stirring, 40 DEG C of fills, oral liquid is made in sterilizing.
When decocting for first and second time, Gypsum Fibrosum need to be with ventilative woven bag parcel.
Embodiment 2
The applicant provides a kind of Chinese medicine oral liquid for treating the airsacculitis that chicken mixed infection causes, by following matter The raw material of amount number is made:
30 parts of Gypsum Fibrosum, 10 parts of Herba Ephedrae, Fructus Gardeniae 10 parts, Radix Scutellariae 10 parts, Fructus Forsythiae 10 parts, Flos Lonicerae 10 parts, Radix Isatidis 10 parts, Fructus Pruni Core 10 parts, Radix Paeoniae Rubra 10 parts, Cortex Moutan 8 parts, Radix Platycodonis 10 parts, Radix Ophiopogonis 10 parts, the Rhizoma Anemarrhenae 10 parts, Fructus Trichosanthis 5 parts, 5 parts of Radix Glycyrrhizae.
The preparation method of described oral liquid specifically comprises the following steps that
(1) soak: Flos Lonicerae, Radix Scutellariae soak 3 hours by the normal-temperature water of 5 times of respective quality respectively；Other raw materials are respectively With 50 DEG C of water soakings 3 hours；
(2) decoct for the first time: with the soak by water of 9 times of all raw material gross masses, water temperature 90 DEG C, 3 hours time；During decoction First putting into other raw materials in addition to Flos Lonicerae, Radix Scutellariae, decoction to 2 is little puts into Radix Scutellariae constantly；
(3) second time decocts: with the soak by water of 7 times of all raw material gross masses, and puts into Flos Lonicerae, and decocting time 2 is little Time；
(4) concentrating: merge the decoction liquor of twice, the extractum that filtering and concentrating becomes relative density to be 1.04, dropping concentration is The sodium citrate solution regulation pH to 6 of 4.2wt%；
(5) adding the sodium benzoate of 6wt% while stirring, 60 DEG C of fills, oral liquid is made in sterilizing.
When decocting for first and second time, Gypsum Fibrosum need to be with ventilative woven bag parcel.
Embodiment 3
The applicant provides a kind of Chinese medicine oral liquid for treating the airsacculitis that chicken mixed infection causes, by following matter The raw material of amount number is made:
15 parts of Gypsum Fibrosum, 6 parts of Herba Ephedrae, Fructus Gardeniae 6 parts, Radix Scutellariae 6 parts, Fructus Forsythiae 6 parts, Flos Lonicerae 6 parts, Radix Isatidis 6 parts, 6 parts of Semen Armeniacae Amarum, Radix Paeoniae Rubra 6 parts, Cortex Moutan 5 parts, Radix Platycodonis 6 parts, Radix Ophiopogonis 6 parts, the Rhizoma Anemarrhenae 6 parts, Fructus Trichosanthis 3 parts, 2 parts of Radix Glycyrrhizae.
The preparation method of described oral liquid specifically comprises the following steps that
(1) soak: Flos Lonicerae, Radix Scutellariae soak 3 hours by the normal-temperature water of 4 times of respective quality respectively；Other raw materials are respectively With 50 DEG C of water soakings 2 hours；
(2) decoct for the first time: with the soak by water of 8 times of all raw material gross masses, water temperature 90 DEG C, time 2 h；During decoction First putting into other raw materials in addition to Flos Lonicerae, Radix Scutellariae, decoction to 1.5 is little puts into Radix Scutellariae constantly；
(3) second time decocts: with the soak by water of 6 times of all raw material gross masses, and puts into Flos Lonicerae, and decocting time 2 is little Time；
(4) concentrating: merge the decoction liquor of twice, the extractum that filtering and concentrating becomes relative density to be 1.02, dropping concentration is The sodium citrate solution regulation pH to 5 of 5.0wt%；
(5) adding the sodium benzoate of 5wt% while stirring, 50 DEG C of fills, oral liquid is made in sterilizing.
When decocting for first and second time, Gypsum Fibrosum need to be with ventilative woven bag parcel.
Test case 1:
The Chinese medicine oral liquid for treating the airsacculitis that chicken mixed infection causes that the present invention provides, uses and has heat clearing away solution Poison, eliminating phlegm and stopping cough, the Chinese prescription of dispersing swelling and dissipating binds, through extracting, be eventually fabricated drink form, convenient administration.
Chinese medicine oral liquid to prepared treatment chicken airsacculitis has carried out clinical experimental study (to mycoplasma gallinarum conjunction below And the therapeutical effect of escherichia coli mixed infection airsacculitis), to verify that it is to the prevention of chicken airsacculitis and therapeutic effect.
1 age in days health Luo Man Adult cockerel, adaptability is raised to 25 ages in days, is randomly divided into four groups, often organizes 80 plumages.Wherein prevent Organize 25 ages in days and give oral liquid of the present invention (1000ml is watered 600kg, and every day uses once, concentrates and drinks), successive administration 5 days； Treatment group 25 age in days gives oral liquid of the present invention (1000ml is watered 600kg, and every day uses once, concentrates and drinks), is used in conjunction 5, Healthy group, infected group are not administered.28 ages in days, infected group, prevention group, treatment group chicken virus mycoplasma R strain+escherichia coli O78 attack Poison bacterium solution 0.1mL of 5.0 × 106CFU/mL concentration (the chest bladder injection concentration be), health group not counteracting toxic substances.
Death condition each counteracting toxic substances group starts death occur for the 3rd day after counteracting toxic substances, within the 5th day, respectively organizes death and peaks.Each group Dead dwell time, prevention group was counteracting toxic substances the 7th day, and treatment group was counteracting toxic substances the 9th day, and infected group was counteracting toxic substances the 10th day.
1, every death toll of each group and dead sum are as shown in table 1.
Table 1
Breath state each counteracting toxic substances group chicken started dyspnea occur in the 2nd day after counteracting toxic substances, the most gradually increases, by the 5th day Dyspnea plumage number peaks, and gradually reduces later.Treatment group the 11st day, prevention group the 10th day, infected group is the 13rd It dyspnea symptom disappears.
2, every dyspnea plumage number of each group and total plumage number are as shown in table 2.
Table 2
3, dead chicken cuts open inspection and balloon injury change
Dead chicken cuts open the visible nasal cavity of inspection, trachea-bronchial epithelial cell has mucus exudate, and myxedema is the most congested.Air bag is muddy Turbid, thickening, surface is coated with canescence or lark fibrinous exudate.Part chicken becomes with pericarditis, pericardial effusion etc. Change.
Each group balloon injury is the highest with infected group, is significantly higher than remaining each group.The balloon injury of therapeutic combination prevention group is Low, between two groups, difference is the most notable.
4, the group net gain of Gain weight each counteracting toxic substances is the highest with prevention group, secondly for treatment group, be significantly higher than infected group (P < 0.05)。
The weightening finish change of each group survival chicken is as shown in table 3.
Table 3
Group Just starting weight End weight Net gain
Treatment group 128.0±5.5 297.6±5.2 169.6±5.2
Prevention group 128.0±5.5 302.3±3.2 174.3±3.2
Infected group 128.0±5.5 247.3±2.1 119.3±2.1
Healthy group 128.0±5.5 330.1±4.4 202.1±4.4
Result shows that the oral liquid treating the airsacculitis that chicken mixed infection causes that the present invention provides can play well Defence, therapeutical effect.Feeding oral liquid of the present invention in advance and can significantly lower airsacculitis sickness rate, its protective rate reaches 90.9%； After airsacculitis disease chicken takes 24h, clinical symptoms disappears substantially, and treatment group is evident in efficacy is better than infected group.
Test case 2:
1 group is blank group, without medicine.
2 group of 25% tilmicosin solution is treated, and 100ml tilmicosin solution is watered 300kg, once-a-day, is used in conjunction 4 Day.
3 group of 6% ambroxol hydrochloride solution is treated, and 100ml6% ambroxol hydrochloride solution is watered 300kg, one day one Secondary, it is used in conjunction 4.
After treatment starts, every day entry disease fowl respiratory tract situation and dead distribution, add up therapeutic effect after treating 4 days.Examination Test result as shown in table 4:
Table 4
From the point of view of the result of the test of upper table, a kind of treat the Chinese medicine oral liquid of the airsacculitis that chicken mixed infection causes, 25% Tilmicosin solution, 6% ambroxol hydrochloride solution treatment group and matched group significant difference.The therapeutic effect of the present invention replaces than 25% Meter Kao Xing solution, the main cause that 6% ambroxol hydrochloride solution is good are this product treating both the principal and secondary aspects of a disease, to causing the various of chicken airsacculitis Disease factor has good therapeutical effect.

Claims (4)

1. the Chinese medicine oral liquid being used for treating the airsacculitis that chicken mixed infection causes, it is characterised in that by following mass parts The raw material of number is made:
Gypsum Fibrosum 10-30 part, Herba Ephedrae 1-10 part, Fructus Gardeniae 1-10 part, Radix Scutellariae 1-10 part, Fructus Forsythiae 1-10 part, Flos Lonicerae 1-10 part, Baphicacanthus cusia Root 1-10 part, Semen Armeniacae Amarum 1-10 part, Radix Paeoniae Rubra 1-10 part, Cortex Moutan 1-8 part, Radix Platycodonis 1-10 part, 1-10 part Radix Ophiopogonis, Rhizoma Anemarrhenae 1-10 part, melon Beach wormwood 1-5 part, Radix Glycyrrhizae 1-5 part.
2. the preparation method being used for treating the Chinese medicine oral liquid of the airsacculitis that chicken mixed infection causes, it is characterised in that concrete Step is as follows:
(1) soak: Flos Lonicerae, Radix Scutellariae soak 2-3 hour by the normal-temperature water of 4-5 times of respective quality respectively；Other raw materials are respectively With 45-50 DEG C of water soaking 2-3 hour；
(2) decoct for the first time: with the soak by water of 8-9 times of all raw material gross masses, water temperature 80-90 DEG C, 2-3 hour time；Decoct First put into other raw materials in addition to Flos Lonicerae, Radix Scutellariae when boiling, decoct and put into Radix Scutellariae constantly to 1.5-2 is little；
(3) second time decocts: uses the soak by water of 6-7 times of all raw material gross masses, and puts into Flos Lonicerae, decocting time 1.5-2 Hour；
(4) concentrate: merge the decoction liquor of twice, the extractum that filtering and concentrating becomes relative density to be 1.01-1.04, regulate pH to 4.3- 6；
(5) adding the sodium benzoate of 4-6wt%, 40-60 DEG C of fill while stirring, oral liquid is made in sterilizing.
Preparation method the most according to claim 2, it is characterised in that when decocting for first and second time, Gypsum Fibrosum need to be with ventilative braiding Bag parcel.
Preparation method the most according to claim 2, it is characterised in that step (4) is the Fructus Citri Limoniae of 3.8-6.0wt% by concentration Acid sodium solution regulation pH value.
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Cited By (1)

* Cited by examiner, † Cited by third party
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CN104606359A (en) * 2015-02-13 2015-05-13 安徽恒源药业有限公司 Traditional Chinese medicinal preparation for treating porcine respiratory disease

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CN102327365A (en) * 2011-07-07 2012-01-25 天津生机集团股份有限公司 Oral liquid for treating air sacculitis caused by colibacillosis of chicken and preparation method thereof
CN103417884A (en) * 2013-08-08 2013-12-04 陕西冠嘉高科生物技术有限公司 Drug for treating chicken airsacculitis and preparation method of drug
CN104083508A (en) * 2014-07-16 2014-10-08 葛洪伟 Preparation method of traditional Chinese medicine preparation for preventing and treating respiratory disease caused by chicken airbag inflammation
CN104644757A (en) * 2013-11-21 2015-05-27 天津中敖生物科技有限公司 Traditional Chinese medicine oral liquid for treating avian influenza and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102327365A (en) * 2011-07-07 2012-01-25 天津生机集团股份有限公司 Oral liquid for treating air sacculitis caused by colibacillosis of chicken and preparation method thereof
CN103417884A (en) * 2013-08-08 2013-12-04 陕西冠嘉高科生物技术有限公司 Drug for treating chicken airsacculitis and preparation method of drug
CN104644757A (en) * 2013-11-21 2015-05-27 天津中敖生物科技有限公司 Traditional Chinese medicine oral liquid for treating avian influenza and preparation method thereof
CN104083508A (en) * 2014-07-16 2014-10-08 葛洪伟 Preparation method of traditional Chinese medicine preparation for preventing and treating respiratory disease caused by chicken airbag inflammation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104606359A (en) * 2015-02-13 2015-05-13 安徽恒源药业有限公司 Traditional Chinese medicinal preparation for treating porcine respiratory disease

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Application publication date: 20161221