CN104644757A - Traditional Chinese medicine oral liquid for treating avian influenza and preparation method thereof - Google Patents
Traditional Chinese medicine oral liquid for treating avian influenza and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine oral liquid for treating avian influenza and a preparation method thereof. The traditional Chinese medicine oral liquid comprises the following ingredients, by weight, 1-10 parts of honeysuckle flower, 10-20 parts of fructus forsythia, 5-30 parts of isatis root, 1-10 parts of dandelion, 10-20 parts of natural indigo, 10-30 parts of licorice and 5-10 parts of gypsum. The traditional Chinese medicine oral liquid has heat-clearing, detoxifying, anti-inflammation, cough-relieving and antiviral effects, has little toxic and side effect, is not easy to generate drug resistance, has high bioavailability, has no drug residue, meets requirements of safe veterinary drug and animal-derived food safety guarantee, and is an ideal traditional Chinese medicine oral liquid for treating avian influenza.
Description
Technical field
The invention belongs to field of veterinary, especially a kind of Chinese medicine oral liquid for the treatment of avian influenza and preparation method thereof.
Background technology
Avian influenza (avian influenza, AI), is called for short bird flu.Be by influenza A virus cause a kind of based on the disease of encroaching on respiratory system.Owing to lacking intersecting protective between the changeableness of AIV antigenicity and pathogenicity and different serotypes strain; over more than 100 year, bird flu is repeatedly popular all over the world; the development of serious harm human health and animal husbandry; especially in recent years, breaking out of bird flu causes huge loss to whole world aviculture.
The clinical main manifestations of bird flu is hat whisker cyanosis, hemorrhage, swollen head is shed tears, dyspnea, and exhaustion is dead, and egg production declines, and some cases may show the nervous symptoms such as obvious ataxia.These disease four seasons all can occur, and each age in days chicken all can infect, and how in mixed infection, the cause of disease is complicated, is often caused by multiple paathogenic factor.Prevention mainly concentrates in vaccine and antiviral drugs two kinds of methods with treatment clinically; vaccine is the means of a kind of effective suppression influenza virus; but need the long period from vaccine injection to generation protection antibody; the more important thing is the antigenic variability due to influenza virus; the effectiveness of vaccine is significantly reduced, and this often affects the effect controlling influenza.These deficiencies of vaccine make the research of Anti-avian influenza virus drugs seem very necessary, they can play the effect of prevention and therapy simultaneously, thus farthest reduce the threat of bird flu virus, at present antibacterial, antiviral, vaccine etc. are commonly used to fowl prevent and treat for clinical, but because the cause of disease is complicated, often difficulty receives good effect.And, due to antibiotic abuse, make drug resistance strain increasing, the residual health that becomes the threat mankind of medicine in body.World Health Organization (WHO) is lay special stress on Drug safety also, and advocate back to nature, this is all alternative therapy, and especially the formulation development of herb therapy provides good opportunity.
Chinese medicine is the pure natural substance that animal body the most easily absorbs, containing multiple biological effective components, toxic and side effects is very micro-, almost noresidue, without Drug resistance, meat products, egg products are had no side effect, free from environmental pollution, make Chinese medicine have unique advantage in control poultry cough.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine oral liquid for the treatment of avian influenza, this Chinese medicine oral liquid, there is heat clearing away, removing toxic substances, antiinflammatory, cough-relieving, antiviral effect, toxic and side effects is little, not easily produce drug resistance, the advantages such as bioavailability is high, drug residue free.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine oral liquid of avian influenza.
The present invention is achieved by the following technical solutions:
A Chinese medicine oral liquid for treatment avian influenza, component and the ratio of weight and number thereof of its Chinese medicine oral liquid are respectively:
Flos Lonicerae 1-10 part;
Fructus Forsythiae 10-20 part;
Radix Isatidis 5-30 part;
Herba Taraxaci 1-10 part;
Indigo Naturalis 10-20 part;
Radix Glycyrrhizae 10-30 part;
Gypsum Fibrosum 5-10 part
Treat a preparation method for the Chinese medicine oral liquid of avian influenza, the step of its preparation method is as follows:
(1) take Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, Radix Glycyrrhizae and Gypsum Fibrosum respectively according to weight proportion to pulverize;
(2) decoct three times after the Flos Lonicerae after middle for step (1) pulverizing, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, Radix Glycyrrhizae and Gypsum Fibrosum being soaked one hour, each amount of water is 5-12 times of medical material total amount, each decoction 0.5-1 hour, collecting decoction, filter, filtrate merges, and being concentrated into relative density is 1.01-1.03.Add 95% ethanol, make alcohol content reach 40%, stir evenly, leave standstill 24 hours, filter, reclaim ethanol to without alcohol taste, add suitable quantity of water, centrifuging and taking supernatant, for subsequent use;
(3) in the supernatant of step (2) gained, add the ethanol of 25-30% volume and the tween 80 of 4-6% volume, stir evenly, filter, subpackage, must treat the Chinese medicine oral liquid finished product of avian influenza.
Advantage of the present invention and beneficial effect are:
The Flos Lonicerae contained in the Chinese medicine oral liquid of 1, this treatment avian influenza, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, the Chinese medicinal ingredients such as Radix Glycyrrhizae and Gypsum Fibrosum, there is good preventive and therapeutic effect, antivirus action successful to the respiratory tract disease that antibacterial and virus cause.To infectious bronchitis of chicken, infectious laryngotracheitis, pneumonia, airsacculitis etc., there is good therapeutic effect simultaneously.
2, the Chinese medicine oral liquid of this treatment avian influenza is by extracting the effective ingredient in Chinese medicine, add the additives such as correctives, antibacterial, and according to the oral liquid that the processing method of oral liquid is synthesized, have taking dose little, delicious, absorb fast, prove effective rapidly, steady quality, be easy to carry, be easy to the advantages such as preservation.
3, the present invention has heat clearing away, removing toxic substances, antiinflammatory, cough-relieving, antiviral effect, have no side effect little, not easily produce drug resistance, bioavailability is high, drug residue free, meeting safe veterinary drug, ensure the requirement of animal-derived food safety, is a kind of Chinese medicine oral liquid of ideal treatment avian influenza.
Detailed description of the invention
The present invention is described in further detail by following examples.It should be noted that: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Flos Lonicerae involved in the present invention, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, Radix Glycyrrhizae and Gypsum Fibrosum all commercially can be bought and obtain.
Embodiment 1
Treat a Chinese medicine oral liquid for avian influenza, component and the weight thereof of its Chinese medicine oral liquid are respectively: Flos Lonicerae 10g; Fructus Forsythiae 100g; Radix Isatidis 50g; Herba Taraxaci 10g; Indigo Naturalis 100g; Radix Glycyrrhizae 100g; Gypsum Fibrosum 50g.
Treat a preparation method for the Chinese medicine oral liquid of avian influenza, the step of preparation method is as follows:
(1) take Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, Radix Glycyrrhizae and Gypsum Fibrosum respectively according to weight proportion to pulverize;
(2) decoct three times after the Flos Lonicerae after middle for step (1) pulverizing, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, Radix Glycyrrhizae and Gypsum Fibrosum being soaked one hour, each amount of water is 5-12 times of medical material total amount, each decoction 0.5-1 hour, collecting decoction, filter, filtrate merges, and being concentrated into relative density is 1.01-1.03.Add 95% ethanol, make alcohol content reach 40%, stir evenly, leave standstill 24 hours, filter, reclaim ethanol to without alcohol taste, add suitable quantity of water, centrifuging and taking supernatant, for subsequent use;
(3) in the supernatant of step (2) gained, add the ethanol of 25-30% volume and the tween 80 of 4-6% volume, stir evenly, filter, subpackage, must treat the Chinese medicine oral liquid finished product of avian influenza.
Embodiment 2
Treat a Chinese medicine oral liquid for avian influenza, component and the weight thereof of its Chinese medicine oral liquid are respectively: Flos Lonicerae 100g; Fructus Forsythiae 200g; Radix Isatidis 300g; Herba Taraxaci 100g; Indigo Naturalis 200g; Radix Glycyrrhizae 300g; Gypsum Fibrosum 100g.
Treat a preparation method for the Chinese medicine oral liquid of avian influenza, the step of preparation method is as follows:
(1) take Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, Radix Glycyrrhizae and Gypsum Fibrosum respectively according to weight proportion to pulverize;
(2) decoct three times after the Flos Lonicerae after middle for step (1) pulverizing, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, Radix Glycyrrhizae and Gypsum Fibrosum being soaked one hour, each amount of water is 5-12 times of medical material total amount, each decoction 0.5-1 hour, collecting decoction, filter, filtrate merges, and being concentrated into relative density is 1.01-1.03.Add 95% ethanol, make alcohol content reach 40%, stir evenly, leave standstill 24 hours, filter, reclaim ethanol to without alcohol taste, add suitable quantity of water, centrifuging and taking supernatant, for subsequent use;
(3) in the supernatant of step (2) gained, add the ethanol of 25-30% volume and the tween 80 of 4-6% volume, stir evenly, filter, subpackage, must treat the Chinese medicine oral liquid finished product of avian influenza.
Embodiment 3
Treat a Chinese medicine oral liquid for avian influenza, component and the weight thereof of its Chinese medicine oral liquid are respectively: Flos Lonicerae 50g; Fructus Forsythiae 150g; Radix Isatidis 200g; Herba Taraxaci 75g; Indigo Naturalis 150g; Radix Glycyrrhizae 150g; Gypsum Fibrosum 80g.
Treat a preparation method for the Chinese medicine oral liquid of avian influenza, the step of preparation method is as follows:
(1) take Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, Radix Glycyrrhizae and Gypsum Fibrosum respectively according to weight proportion to pulverize;
(2) decoct three times after the Flos Lonicerae after middle for step (1) pulverizing, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, Radix Glycyrrhizae and Gypsum Fibrosum being soaked one hour, each amount of water is 5-12 times of medical material total amount, each decoction 0.5-1 hour, collecting decoction, filter, filtrate merges, and being concentrated into relative density is 1.01-1.03.Add 95% ethanol, make alcohol content reach 40%, stir evenly, leave standstill 24 hours, filter, reclaim ethanol to without alcohol taste, add suitable quantity of water, centrifuging and taking supernatant, for subsequent use;
(3) in the supernatant of step (2) gained, add the ethanol of 25-30% volume and the tween 80 of 4-6% volume, stir evenly, filter, subpackage, must treat the Chinese medicine oral liquid finished product of avian influenza.
Clinical practice
In order to verify the clinical therapeutic efficacy of the present invention to avian influenza, we have carried out the clinical trial of the avian influenza that the present invention causes chicken natural infection bird flu virus in the cultivation factory of certain infection bird flu virus of Linyi.The present invention is divided into basic, normal, high three dosage to carry out grouping administration to animal by test, compares, thus evaluate therapeutic effect of the present invention and optimum amount with the therapeutic effect of the conventional treatment drug of avian influenza.
1, materials and methods
1.1 experimental animal
There is the laying hen field of avian influenza in Weifang City of Shandong Province, prevalence is up to more than 95%.
1.2 trial drug
The present invention is prepared by our company.
Fowl Tyke: 100g/ bottle, Henan Hui get animal pharmaceutical estate company limited, produces lot number * * * * * *
1.3 test method
The case of avian influenza is primarily of clinical symptoms, and the methods such as inspection change and Virus Isolation of cuing open are made a definite diagnosis, and then sick chicken random packet are treated by experimenter.
The diagnostic criteria of 1.4 avian influenzies
Clinical symptoms:
Sick chicken loss of appetite, lassitude, clinical manifestation is hat whisker cyanosis, hemorrhage, and swollen head is shed tears, dyspnea, and exhaustion is dead, and egg production declines, and some cases may show the nervous symptoms such as obvious ataxia and cut open inspection change:
Main visible cephalledema, subcutaneous have gelatin liquid, neck (breast) portion's subcutaneous dropsy and hyperemia, bird flu specific drug characteristic pathological changes is oral cavity, glandular stomach, muscular stomach cutin membrane lower floor and duodenal hemorrhage, chest muscle, heart are dispersed in petechia, and liver, spleen, stomach have the little necrosis region of lark, ovary or fallopian tube hyperemia or hemorrhage, peritoneum and pericardium have hyperemia or hydrops, and some case has fibrinous exudate.
Virus Isolation:
Gather tracheal mucus or cloaca mucus, or pathological tissues (respiratory tract, digestive tract), add pure water and make homogenate (10% suspension), low speed refrigerated centrifuge (desk-top or vertical) 3, 000 ~ 4, 000rpm, 4 DEG C ~ 5 DEG C, 15 ~ 20 points, abandon precipitation, namely rough virus liquid is obtained, available negative staining process (draws suspension with capillary tube, drop on the copper mesh with supporting film, can immediately or after placing several minutes according to the concentration of sample in suspension, surplus liquid is sucked from liquid pearl edge with filter paper, then (the conventional heavy metallic salt configuration: as PTA (phosphotungstic acid) of negative staining liquid is dripped, KPT (phosphotungstic acid potassium), NaPT (Sodium phosphotungstate), sodium acetate, sodium formate, ammonium molybdate etc.), dyeing time 1 ~ 2 minute, then dye liquor is sucked with filter paper, rear upper transmission electron microscope observation to be dried.By the observation to morphology of virus, determine that this virus is influenza A.
1.5 experimental animal groupings and process
The sick chicken of abiogenous avian influenza is divided into 5 groups at random, and often group is no less than 300.
Testing 1 group is matched group, does not process;
Testing 2 groups is low dose group of the present invention, 1/2 times amount administration of clinical recommended dose (per kilogram of body weight 1mL), mixed drink, successive administration 5 days.
Testing 3 groups is dosage group in the present invention, clinical recommended dose (per kilogram of body weight 2mL) administration, mixed drink, successive administration 5 days.
Testing 4 groups is high dose group of the present invention, 2 times amount administrations of clinical recommended dose (per kilogram of body weight 4mL), mixed drink, successive administration 5 days.
Testing 5 groups is fowl Tyke group, uses to specifications: mixed drink, is watered the amount administration of 300 kilograms, successive administration 5 days by 100g.
1.6 therapeutic effect decision methods
Clinical symptom disappearance, cuts open inspection without obvious pathological change, detects HA-HI test result lower than 4 ㏒ by Microhemagglutination test (HA) method
2for curing.
Cure rate:
Medication postoperative infection chicken clinical symptom disappearance, spirit, appetite, breathing etc. are recovered all to be judged as normally curing.The ratio calculating cure rate that this group tests chicken is accounted for according to curing number of elements.
Effective percentage:
Medication postoperative infection cockscomb whisker cyanosis, hemorrhage, swollen head is shed tears, dyspnea, degradation clinical symptom relief under egg production, and spirit and the situation of searching for food start to take a turn for the better but do not return to all being judged to effectively of premorbid state.The ratio accounting for this group test chicken number of elements according to effective number of elements calculates effective percentage.
Inefficiency:
Medication postoperative infection chicken spirit, appetite, cockscomb whisker cyanosis, hemorrhage, swollen head is shed tears, dyspnea, and under egg production, degradation symptom is not still felt any better and even worsened died, and it is invalid to be all judged as.The ratio accounting for this group test number of elements according to invalid number of elements calculates inefficiency.
1.7 statistical analysis
The percents such as therapeutic effect cure rate, effective percentage represent.Comparison in difference between group adopts X 2 test to analyze.P<0.05 and P<0.01 represents significant difference and extremely remarkable respectively.
2 result of the tests
To the chicken group of natural infection bird flu virus, give the oral liquid of various dose respectively, after mixed drink, by comparing with matched group, the clinical symptoms of morbidity chicken group obviously alleviates, and laying rate rises.The therapeutic effect of middle dosage group and the recovery situation of laying rate all reach desirable requirement; Fowl Tyke treatment of control group effect is ideal, but the recovery situation of laying rate is obviously not as the present invention.The results are shown in Table 1.
Table 1 observation of curative effect
3 interpretations of result
From clinical symptoms, cut open inspection change, laying rate, cure rate four aspects analyze, the therapeutic effect of middle dosage group and high dose group apparently higher than other treatment group, wherein with the prevention effect of middle dosage group the best.
4 conclusions
The present invention is by per kilogram of body weight 2mL administration, and mixed drink, treats the chicken group of natural infection bird flu virus, achieve good therapeutic effect for continuous 5 days.Meanwhile, good prevention effect is also had to the disease such as infectious bronchitis, laryngotracheitis, pneumonia, airsacculitis by poultry.
Claims (2)
1. treat a Chinese medicine oral liquid for avian influenza, it is characterized in that: the component of this Chinese medicine oral liquid and ratio of weight and number thereof are:
Flos Lonicerae 1-10 part;
Fructus Forsythiae 10-20 part;
Radix Isatidis 5-30 part;
Herba Taraxaci 1-10 part;
Indigo Naturalis 10-20 part;
Radix Glycyrrhizae 10-30 part;
Gypsum Fibrosum 5-10 part.
2. a preparation method for the Chinese medicine oral liquid for the treatment of avian influenza as claimed in claim 1, is characterized in that: the step of this preparation method is as follows:
(1) take Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, Radix Glycyrrhizae and Gypsum Fibrosum respectively according to weight proportion to pulverize;
(2) decoct three times after the Flos Lonicerae after middle for step (1) pulverizing, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Indigo Naturalis, Radix Glycyrrhizae and Gypsum Fibrosum being soaked one hour, each amount of water is 5-12 times of medical material total amount, each decoction 0.5-1 hour, collecting decoction, filter, filtrate merges, and being concentrated into relative density is 1.01-1.03.Add 95% ethanol, make alcohol content reach 40%, stir evenly, leave standstill 24 hours, filter, reclaim ethanol to without alcohol taste, add suitable quantity of water, centrifuging and taking supernatant, for subsequent use;
(3) in the supernatant of step (2) gained, add ethanol and the 4-6% tween 80 of 25-30%, stir evenly, filter, subpackage, must treat the Chinese medicine oral liquid finished product of avian influenza.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105998216A (en) * | 2016-06-21 | 2016-10-12 | 刘月华 | Anti-virus oral liquid for poultry and preparation technology thereof |
| CN106237070A (en) * | 2016-08-31 | 2016-12-21 | 无锡正大生物股份有限公司 | A kind of Chinese medicine oral liquid for treating the airsacculitis that chicken mixed infection causes |
| CN106421305A (en) * | 2016-09-30 | 2017-02-22 | 安徽华澳生物技术有限公司 | Medicament for preventing and controlling avian airsacculitis |
| CN106511483A (en) * | 2015-09-09 | 2017-03-22 | 韦爽姬 | Medicine for treating chicken avian influenza |
| CN108837053A (en) * | 2018-08-14 | 2018-11-20 | 黔西南州中宏家禽养殖有限公司 | It is a kind of to treat chicken cold medicine and preparation method thereof |
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| CN102579779A (en) * | 2012-03-22 | 2012-07-18 | 郭耀亭 | Chinese medicinal composition, Chinese medicinal preparation and feed for treating and/or preventing respiratory system diseases of livestock |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102579779A (en) * | 2012-03-22 | 2012-07-18 | 郭耀亭 | Chinese medicinal composition, Chinese medicinal preparation and feed for treating and/or preventing respiratory system diseases of livestock |
Non-Patent Citations (2)
| Title |
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| 邢兰君: "鹌鹑新城疫并发大肠杆菌病的诊治", 《中国动物保健》 * |
| 陈振勇: "浅谈鸡新城疫的预防与治疗", 《中国畜禽种业》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511483A (en) * | 2015-09-09 | 2017-03-22 | 韦爽姬 | Medicine for treating chicken avian influenza |
| CN105998216A (en) * | 2016-06-21 | 2016-10-12 | 刘月华 | Anti-virus oral liquid for poultry and preparation technology thereof |
| CN106237070A (en) * | 2016-08-31 | 2016-12-21 | 无锡正大生物股份有限公司 | A kind of Chinese medicine oral liquid for treating the airsacculitis that chicken mixed infection causes |
| CN106421305A (en) * | 2016-09-30 | 2017-02-22 | 安徽华澳生物技术有限公司 | Medicament for preventing and controlling avian airsacculitis |
| CN108837053A (en) * | 2018-08-14 | 2018-11-20 | 黔西南州中宏家禽养殖有限公司 | It is a kind of to treat chicken cold medicine and preparation method thereof |
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