CN102579779A - Chinese medicinal composition, Chinese medicinal preparation and feed for treating and/or preventing respiratory system diseases of livestock - Google Patents
Chinese medicinal composition, Chinese medicinal preparation and feed for treating and/or preventing respiratory system diseases of livestock Download PDFInfo
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Abstract
The invention relates to the field of veterinary medicines, in particular to a Chinese medicinal composition, a Chinese medicinal preparation and a feed for treating and/or preventing respiratory system diseases of livestock. The Chinese medicinal composition is prepared from gypsum, honeysuckle, indigowoad root, baical skullcap root, weeping forsythia, common anemarrhena rhizome, platycodon root and liquoric root. The Chinese medicinal composition, the Chinese medicinal preparation and the feed have the effects of freeing lung, relieving asthma, reducing phlegm, relieving cough, clearing heat and detoxifying, resisting bacteria, diminishing inflammation and improving the immunity of organisms, have a simple production process, are low in cost, do not have toxic or side effects, and can prevent and control various respiratory system diseases of the livestock, enhance the resistance of the organisms, avoid livestock diseases and improve the yield of livestock products.
Description
Technical field
The present invention relates to field of veterinary, particularly a kind of Chinese medicine composition, Chinese medicine preparation and feedstuff that treats and/or prevents respiratory illness of livestock and poultry.
Background technology
Along with the expansion of intensive culture scale, the systemic disease of not washing of poultry is serious day by day trend, and simultaneously owing to the abuse of antibiotics aspect livestock and poultry cultivation, research and development Resistant strain difficulty is increasing.
The outburst of respiratory illness of livestock and poultry has had a strong impact on poultry feed intake, efficiency of feed utilization, and the poultry laying rate reduces, domestic animal carcass quality degradation, even causes a considerable amount of death of poultry, has had a strong impact on raiser's economic benefit.
Current, the concurrent or secondary mixed infection of the generation of respiratory illness of livestock and poultry and multiple infectious disease, main kind has 3 kinds: bacterial disease, the disease of virus, parasitic infection.Thereby take place unknown cause swelling, shed tears, rhinorrhea, cough, sneeze, breathe, symptom such as dyspnea.
Domestic animal is example with the pig, and poultry is example with the chicken.
China is the world big country of raising pigs; Since the eighties in 20th century, along with economic development and industry restructuring, three transformations have progressively taken place in Swine Production: changed to intensive style by decentralized; Change to modernized pattern by traditional mode, change to mass type by scalar type.Large scale of pig farm, stocking density is increasing, and international trade contacts are gradually many, introduce a fine variety also more and more frequent.And China's swine diseases integrated control system imperfection, understanding disunity, especially vaccine development relatively lag behind, cause all kinds of eqpidemic diseases especially respiratory tract disease day by day increase and be increasingly sophisticated.In the environment of sealing, stocking density is excessive, causes easily being propagated in swinery and between the swinery by airborne cause of disease.Cause serious economic losses such as the swinery speed of growth is slow, feed conversion rate low, mortality rate rising, medical expense increase.It sees with rhinitis, pneumonia usually, is common symptoms with cough, sneeze, dyspnea, and the susceptible swinery is regardless of kind, sex, age.(porcine respiratory disease complex PRDC) has become the No.1 disease that influences global pig industry economic benefit to porcine respiratory disease complex at present.The similar this mixed infection that is caused by multiple cause of disease, multifactor interaction will be the main difficult problem that faces of pig industry from now on.Therefore, the respiratory tract disease of pig is considered to one of subject matter that perplexs the pig farm production and operation.
From pathology,, can be divided into 3 kinds of main types: rhinitis, pneumonia, pleuritis by its site of pathological change.Different Kinds of Pathogens is attacked different physiological location, causes each system's symptom of target organ damage or whole body.Aborning, common respiratory system disease can be divided into following several types: (1) bacillary respiratory system disease mainly contains mycoplasma pneumonia (mycoplasma pneumoniae of swine; MH), actinobacillus suis pleuropneumonia (APP), pig streptococcicosis (SS); Progressive atrophoderma property rhinitis (AR), pig lung plague etc.; (2) viral respiratory system disease mainly contains pig breeding and respiratory system obstacle syndrome (PRRS), pseudorabies (PR), swine flue (SI), swine fever (HC) etc.; (3) respiratory system disease of antibacterial and virus mixed infection mainly contains porcine respiratory disease complex (PRDC), pig wean back multisystemic exhaustion syndrome (PMWS) etc.; (4) parasitic respiratory system disease is like the respiratory system disease that is caused by ascarid, back strongylid, lung filaricide etc.
Respiratory system disease is to one type of maximum disease of poultry husbandry harm, especially in today of large-scale cultivation industry, can cause the weightening finish of efficiency of feed utilization and chicken to descend, the reduction of laying eggs, even cause chicken dead.The respiratory system disease more complicated of chicken, what have is caused by virus, what have is caused by antibacterial and mycoplasma.The respiratory system disease incidence rate of chicken is higher, and the chicken of various ages in days all is prone to infected; On the other hand the respiratory system disease sickness rate of chicken high and be prone to cause multiple disease secondary infection, chick growth hypoevolutism, grow up that laying rate of chicken descends, the death of various age in days chickens.Common disease has chicken chronic respiratory tract disease, infectious bronchitis of chicken, infectious laryngotracheitis of chicken, infectious coryza of chicken, newcastle disease etc.
Solve above-mentioned symptom and can adopt chemicals such as various antibiotic, hormone, synthetically grown agent usually, but be prone to cause harmful substance to be detained in the poultry body, the serious harm human health.Selling in the market has the Chinese medicine ingredients that treats and/or prevents respiratory illness of livestock and poultry, but effect is little mostly, cures slowly.Therefore, provide a kind of Chinese medicine composition, Chinese medicine preparation and feedstuff that treats and/or prevents respiratory illness of livestock and poultry to have realistic meaning.
Summary of the invention
In view of this, the present invention provides a kind of Chinese medicine composition, Chinese medicine preparation and feedstuff that treats and/or prevents respiratory illness of livestock and poultry.This Chinese medicine composition is processed by Gypsum Fibrosum, Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Fructus Forsythiae, the Rhizoma Anemarrhenae, Radix Platycodonis, Radix Glycyrrhizae.This Chinese medicine composition, Chinese medicine preparation and feedstuff can depressed lung-energy dispersing, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing, anti-inflammation, human body immunity improving power, and production technology is simple, and cost is low, has no side effect.Can the various respiratory system diseases of prophylactic treatment poultry, the enhancing body resistance reduces livestock and poultry and takes place, and improves animal products output.
In order to realize the foregoing invention purpose, the present invention provides following technical scheme:
The invention provides a kind of Chinese medicine composition that treats and/or prevents respiratory illness of livestock and poultry, process by following parts by weight of component:
Gypsum Fibrosum 200～400 weight portions, Flos Lonicerae 50～200 weight portions, Radix Isatidis 60～180 weight portions, Radix Scutellariae 60～180 weight portions, Fructus Forsythiae 50～150 weight portions, the Rhizoma Anemarrhenae 40～120 weight portions, Radix Platycodonis 40～120 weight portions, Radix Glycyrrhizae 25～75 weight portions.
Gypsum Fibrosum, Gypsum Fibrosum are the monoclinic system mineral, and main chemical compositions is calcium sulfate (CaSO
4), theoretical (wB%): CaO 32.5, the SO of forming
346.6, H
2O
+20.9.Composition changes little.Mechanical tramp materials such as clay, organic matter are often arranged, contain SiO sometimes
2, Al
2O
3, Fe
2O
3, MgO, Na
2O, CO
2, element such as impurity such as Cl and micro strontium, barium.Be used for expelling pathogenic factors from muscles for clearing heat, relieving restlessness is quenched the thirst, heat-clearing and toxic substances removing.
Flos Lonicerae is Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or the first flower of opening of band.Contain chlorogenic acid, glycoside, flavonoid, volatile oil composition.Glycosides composition comprises Saponin, iridoid glycoside etc., as being the triterpenoid saponin of aglucon with Caulis Hederae Sinensis glycoside unit, being the triterpenoid saponin of glycoside unit with the caryophyllin; Flavone compound has 5-hydroxyl-3 ', and 4,7-trimethoxy flavone, luteolin-7-O-a-D-glycoside, luteolin-7-O-b-D-galactoside, Quercetin-3-O-b-D-glycoside, hyperin etc.; Contain composition more than 30 kinds in the volatile oil, main constituent is the pure and mild linalool of Flos Lonicerae.In addition, there is report from the Flos Lonicerae leaf, to get 8 kinds of pure glycosides or phenol glycoside, is mainly polyhydric alcohol glycoside, different lignan glycoside, coumarin glycoside etc., have resisting pathogenic microbes, antitoxin, antiinflammatory, antipyretic effect.Can be used for heat-clearing and toxic substances removing.Cure mainly epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle furuncle, sore throat and multiple infectious disease.
Radix Isatidis is divided into northern Radix Isatidis and Rhizoma Et Radix Baphicacanthis Cusiae, and northern Radix Isatidis source is the root of cruciferae isatis (Isatis tinctoria L.) and careless Folium Isatidis (I.indigotica Fort.); Rhizoma Et Radix Baphicacanthis Cusiae is acanthaceous vegetable acanthaceous indigo (Baphicacanthus cusia (Nees) Brem.) rhizome and a root.Effect with heat-clearing and toxic substances removing, removing heat from blood detumescence, sore-throat relieving.That the Isatis indigotica Fort. root contains is indigo (indigotin, indigo), indirubin (indirubin); Anthraquinone class, cupreol (β-sitosterol), clionasterol (γ-sitosterol) and several amino acids: arginine (arginine), glutamic acid (glutamic acid); Tyrosine (tyrosine); Proline (proline), valine (valine), GABA (γ-aminobu-tyric acid).Also contain potassium myronate (sinigrin); The indigo glycoside (indoxyl-β-hlucoside), couroupitine A (trptanthrin), 1-Hydrogen thiocyanate-2-hydroxyl fourth-3-alkene (1-thiocyano-2-hydroxy-3-butene); Table is accused Yichun (epigoitrin); Gland glycoside (adenosine), Palmic acid (palmitic acid), sucrose (sucrose) and contain 12% amino acid whose proteoglycan.The antibacterial substance and the kinetin that also contain resisting gram-positive and negative bacteria.
Radix Scutellariae, another name Radix Scutellariae, tsuchikane tea root.For labiate Radix Scutellariae (Scutellaria baicalensis Georgi), be used as medicine with root.Heat clearing and damp drying is arranged, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.
Scutellariae,radix contains flavone compound: baicalin (baicalein), neobaicalein (neobaicalein), i.e. skullcapflavone II (skullcapflavone II), baicalin (baicalin), wogonin (wogonin); Wogonoside (wogono-side), oroxylin A (oroxylin, oroxylin A), 7-methoxyl group baicalin (7-methoxbaic alein), skullcapflavone (skullcapflavone) I; Dihydro oroxylin A (dihydrooroxylin A), chrysin (chrysin), 2,5,8-trihydroxy-7-methoxy flavone (2; 5,8-trihydroxy-7-methoxy-flavone), 2,5; 8-trihydroxy-6, and the 7-dimethoxy flavone (2,5,8-trihydroxy-6; 7-dimethoxyflavone) 4,5,7-trihydroxy-6-methoxyl group flavanone (4,5; 7-trhydroxy-6-methoxyflavanone) [5], 2,3,5; 6,7-penta hydroxy group flavanone (2,3,5; 6,7-pentahydroxyflavanone) wogonin-5-β-D-glycoside (wogonin-5-β-D-glucoside), 2-(3-hydroxyl-4-methoxyphenyl)-ethyl-1-O-α-L-rhamanopyranosyl (1 → 3)-β-D (4-Resina Ferulae acyl group)-glucose [2-(3-hydroxy-4-methoxyphenyl) ethyl-1-O-α-L-rhamnosyl (1 → 3)-β-D-(4-feruloyl) glucoside], chrysin; (chrysin-6-C-β-D-glucoside-8-C-β-L-arabinoside), (chrysin-6-C-α-L-arabi-noside-8-C-β-D-glucoside), (2S)-2,5,6,7-tetrahydroxy flavanone [(2S)-25 for chrysin-6-C-α-L-arabinose glycoside-8-C-β-D-glycoside for-6-C-α-L-arabinose glycoside; 6,7-terahydroxyflavanone], 5,7,2,6-kaempferol (5; 7,2,7-tetrahydroxyflavone), 5,8-dihydroxy-6,7-dimethoxy flavone (5; 8-dihydroxy-6,7-drimethoxyflavone), 5,7,4-trihydroxy-8-methoxy flavone (5,7; 4-trihydroxy-8-methoxyflavone), oroxylin A-7-O-glucuronide (oroxylinA-7-O-glucuronide), 5,7,2-trihydroxy methoxy flavone (5,7; 2-trihyroxy-6-methoxyflavone), 5,2-dihydroxy-6,7,8-trimethoxy flavone (5,2-dihydroxy-6; 7,8-trimethoxyfla-vone), 5-gate of a lane base-7, the 8-dimethoxy flavone (5-hydroxy-7,8-dimethoxy-flavone), nor-wogonin (norwogonin); Dihydro baicalin (dihydro-baicalin) [11], 5,7, the 2-trihydroxyflavone (5,7,2-trihydroxyflavone); 5,7,2-trihydroxy-8, the 6-dimethoxy flavone (5,7,2-trihydroxy-8; 6-dimethoxyflavone), 5,7,2,5-tetrahydroxy-8.The 6-dimethoxy flavone is viscidulin III (5,7,2; 5-tetrahydroxy-8,6-dimethoxyflavone, vis-ciduiin III) 5; 25-trihydroxy trimethoxy flavone (5,2,5-trihy-droxy-6; 7,8-trimethoxyflavone), baicalin-7-O-β-D-glucopyanoside (baicalein-7-O-β-D-glucopyranoside); 5,7, and 2-trihydroxy-8-methoxy flavone (5,7,2-trhiyroxy-8-methoxyflavone) be tenaxin II (tenax-in II), 5,2; 6-trihydroxy-7, the 8-dimethoxy flavone (5,2, and 6-trihydroxy-6-methoxy flavone (5,7,2-trihydroxy-6-methoxyflavone), 5; 7,2, and the 3-kaempferol (5,7,2-trihydroxy-6-methoxyflavone), 5,7; 2, and 3-four great basic flavone (5,7,2,3-tetrahydroxyflavone), 3,5; 7,2,5,6-pentahydroxyflavone (3,5,7,2; 6-pentahydroxyflavone) be viscidulin I (viscidulin I), (2S)-7,2,6-trihydroxy-5-methoxyl group flavanone [(2S)-7,2,6-trihydroxy-5-methoxyflavanone], 2; 6,2, and 4-tetrahydroxy-6-methoxyl group chalcone (2,6,2,4-tetrahydroxy-6-methoxychalcone) [13], 5; 72, the 5-kaempferol (5,7,2,5-tetrahydroxyflavone), left-handed eriodictyol (eriodictyol), Herba Scutellariae Barbatae kind plain (rivularin) and viscidulin III-2-O-β-D-glucopyanoside (viscidulin III-2-O-β-D-glucoplyranoside) etc.Also contain cupreol (β-sitosterol), campesterol (campesterol) and stigmasterol (stigmasterol) [3] in addition.2. the Yunnan scutellariae,radix contains the river rising in Ningxia and flowing into central Shaanxi baicalin, baicalin, and baicalin, wogonoside, 5,7,2-trihydroxy-6-methoxy flavone, (2S)-5; 7,8-trihydroxy flavanone [(2S)-5,7,8-trihydroxyflavanone], (2S)-2,5,6; 7-tetrahydroxy flavane baicalin, oroxylin A, scuteamoenoside (scuteamoenoside), (2R, 3R)-2,3,5; 7-tetrahydroxy flavanone [(2R, 3R)-2,3,5,7-tetrahydrox-yflavanone], scuteamoenin (scuteamoenin), (2R; 3R)-3,5,7-trihydroxy flavanone-(2R, 3R)-3,5,7-trihydroxyflavanone], skullcapflavone II; 2,3,5,6,7-pentahydroxyflavone, chrysin, cupreol.3. the Sutellaria viscidula root contains baicalin, wogonoside, and baicalin, wogonin, oroxylin A, neobaicalein, 5,2-dihydroxy dimethoxy flavone (panicolin) is skullcapflavone I, viscidulin I, II, III.The Lijing scutellariae,radix contains baicalin, wogonin, chrysin, oroxylin A, tenaxin II, sticking kilocycle baicalin I.Congener scutellaria rehderiana Diels root contains rehderianin (rehderianin) I, viscidulin III, baicalin, wogonin, baicalin, oroxylin A, Gansu a kind of reed mentioned in ancient books glycoside unit (ganhuangenin).The scutellaria hypericifolia root contains baicalin, wogonoside, baicalin, viscidulin I, II, oroxylin A and wogonin.
Forsythia, Oleaceae (Oleaceae) Forsythia (Forsythia) plant forsythia (Forsythia? Suspensa (Thunb.) Vahl) dried fruit, wood-containing liposomes compounds: forsythia glycosides (forsythin, phillyrin), forsythia aglycone (phillygenin), dextral turpentine phenol (pinoresinol), D Pinoresinol glucoside (pinoresinol-β-D-glucoside); flavonoids: rutin (rutin); styrene derivatives: forsythia fat glycosides (forsythoside) A, C, D, E, forsythia, dogwood glycosides (suspensaside), Mao Liu glycosides (salidroside); Ethylcyclohexanone alcohol derivatives: spine wood glycosides (cornoside), forsythia cyclohexanol (rengyol ), different forsythia cyclohexanol (isorengyol), etc., still contain triterpenoids: betulinic acid (betulinic? acid), ursolic acid, oleanolic acid and so on.There are antibiotic, heart tonifying, diuresis, town pharmacological action, diseases such as the acute anemopyretic cold of forsythia fruit for treating commonly used, carbuncle sore tumefacting virus, tuberculous lymphadenitis, urinary tract infection such as to tell.
The Rhizoma Anemarrhenae is the dry rhizome of monocotyledon Liliaceae Liliaceae Rhizoma Anemarrhenae Anemarrhena asphodeloidesBge..Contain timosaponin, flavones ingredient cures mainly epidemic febrile disease, hyperpyrexia excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, the stranguria with turbid discharge of quenching one's thirst.
Radix Platycodonis is the root of dicotyledon campanulaceae Campanulaceae Radix Platycodonis Platycodon grandiflorum (Jacq.) A.DC..Bitter in the mouth, suffering, slightly warm in nature.Go into lung meridian.The ability expelling phlegm for arresting cough, and lung qi dispersing, evacuation of pus effect are arranged.Contain multiple Saponin, the ruscogenin of getting after the hydrolysis has: platycodigenin (platycodigenin), and a spot of new Polygalacic acid (polygalacic acid), platycogenic acid A, B, C (platycogenic acid A, B, C).In addition, from Saponin, still getting prosapogenins (prosapogenin), be secondary glycoside, is platycodigenin-3-O-β-glycoside.By getting platycodoside C (platycodoside C) in total Saponin, hydrolysis generate platycodigenin and glucose, xylose, rhamnose, arabinose (2: 1: 1: 1). root contains hitodesterol, hitodesterol-β-D-glycoside, birch skin pure (betulin), Radix Platycodonis Polyfructose. (platycodinin), aminoacid in addition.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.
Radix Glycyrrhizae is dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensisFisch., the root and rhizome of Glycyrrhiza inflata Bat. G.inflataBat. or Glycyrrhiza glabra L. G.glabraL..Contain the number of chemical composition, main component has glycyrrhizic acid, liquiritin etc.The chemical composition of Radix Glycyrrhizae is very complicated; Isolated chemical compound has tens of kinds of chemical compounds such as glycyrrhizin, enoxolone, liquiritin, isoliquiritin, neoliquriitin, neoisoliquiritin, glycyrrhizin, isoliquiritigenin and licoricidin (+)-Licoricidin., glycyrol, isoglycyrol, 7-methylcoumarin essence, umbelliferone from Radix Glycyrrhizae so far, but that these compositions and quantity usually can be with factors such as the kind of Radix Glycyrrhizae, planting area, collecting times is different and different.A large amount of researchs show that glycyrrhizin and Flavonoid substances are most important biological active substanceies in the Radix Glycyrrhizae, mainly are present in the licorice epidermis with interior part.Radix Glycyrrhizae has antiinflammatory, antiviral and effects such as protecting liver and detoxication and raise immunity.Do not have serious adverse reaction owing to glycyrrhizic acid has the pharmacological action of glucocorticoid appearance, clinically be widely used in treating various acute, chronic hepatitis, bronchitis and AIDS, also have functions such as anti-cancer and cancer-preventing, interferon inducer and cell immunomodulator.Glycyrrhizic acid has blood fat reducing and study of anti-atherogenic effect, stops atherosclerotic formation.
In some embodiments of the invention, Chinese medicine composition provided by the invention is processed by following parts by weight of component:
Gypsum Fibrosum 200～380 weight portions, Flos Lonicerae 50～150 weight portions, Radix Isatidis 120～150 weight portions, Radix Scutellariae 120～140 weight portions, Fructus Forsythiae 50～110 weight portions, the Rhizoma Anemarrhenae 65～120 weight portions, Radix Platycodonis 80～100 weight portions, Radix Glycyrrhizae 25～60 weight portions.
In other embodiment of the present invention, Chinese medicine composition provided by the invention, it is processed by following parts by weight of component:
Gypsum Fibrosum 300 weight portions, Flos Lonicerae 150 weight portions, Radix Isatidis 120 weight portions, Radix Scutellariae 120 weight portions, Fructus Forsythiae 100 weight portions, the Rhizoma Anemarrhenae 80 weight portions, Radix Platycodonis 80 weight portions, Radix Glycyrrhizae 50 weight portions.
The present invention also provides a kind of method for preparing that treats and/or prevents the Chinese medicine composition of respiratory illness of livestock and poultry, and raw material is made up of following parts by weight of component:
Gypsum Fibrosum 200～400 weight portions, Flos Lonicerae 50～200 weight portions, Radix Isatidis 60～180 weight portions, Radix Scutellariae 60～180 weight portions, Fructus Forsythiae 50～150 weight portions, the Rhizoma Anemarrhenae 40～120 weight portions, Radix Platycodonis 40～120 weight portions, Radix Glycyrrhizae 25～75 weight portions;
Said raw material mixes, sieving promptly gets after 30～200 orders are pulverized.
In some embodiments of the invention, in the method for preparing of Chinese medicine composition provided by the invention, raw material is processed by following parts by weight of component:
Gypsum Fibrosum 200～380 weight portions, Flos Lonicerae 50～150 weight portions, Radix Isatidis 120～150 weight portions, Radix Scutellariae 120～140 weight portions, Fructus Forsythiae 50～110 weight portions, the Rhizoma Anemarrhenae 65～120 weight portions, Radix Platycodonis 80～100 weight portions, Radix Glycyrrhizae 25～60 weight portions.
In other embodiment of the present invention, in the method for preparing of Chinese medicine composition provided by the invention, raw material is processed by following parts by weight of component:
Gypsum Fibrosum 300 weight portions, Flos Lonicerae 150 weight portions, Radix Isatidis 120 weight portions, Radix Scutellariae 120 weight portions, Fructus Forsythiae 100 weight portions, the Rhizoma Anemarrhenae 80 weight portions, Radix Platycodonis 80 weight portions, Radix Glycyrrhizae 50 weight portions.
The present invention also provides a kind of Chinese medicine preparation that treats and/or prevents respiratory illness of livestock and poultry, is made up of above-mentioned Chinese medicine composition and acceptable accessories.Above-mentioned Chinese medicine composition is processed by following parts by weight of component:
Gypsum Fibrosum 200～400 weight portions, Flos Lonicerae 50～200 weight portions, Radix Isatidis 60～180 weight portions, Radix Scutellariae 60～180 weight portions, Fructus Forsythiae 50～150 weight portions, the Rhizoma Anemarrhenae 40～120 weight portions, Radix Platycodonis 40～120 weight portions, Radix Glycyrrhizae 25～75 weight portions.
In some embodiments of the invention, a kind of Chinese medicine preparation that treats and/or prevents respiratory illness of livestock and poultry provided by the invention, it is powder, water solube powder, solution, injection or tablet.
In some embodiments of the invention, when a kind of Chinese medicine preparation that treats and/or prevents respiratory illness of livestock and poultry provided by the invention is water solube powder, be specially water diffusibility powder or water-soluble granular formulation.
In some embodiments of the invention, when a kind of Chinese medicine preparation that treats and/or prevents respiratory illness of livestock and poultry provided by the invention is injection, be specially water for injection injection or powder ampoule agent for injection.
The present invention also provides a kind of feedstuff that improves poultry feed intake and feed conversion rate, is made up of acceptable additive in above-mentioned Chinese medicine composition, feedstuff and the feedstuff.Above-mentioned Chinese medicine composition is processed by following parts by weight of component:
Gypsum Fibrosum 200～400 weight portions, Flos Lonicerae 50～200 weight portions, Radix Isatidis 60～180 weight portions, Radix Scutellariae 60～180 weight portions, Fructus Forsythiae 50～150 weight portions, the Rhizoma Anemarrhenae 40～120 weight portions, Radix Platycodonis 40～120 weight portions, Radix Glycyrrhizae 25～75 weight portions.
In some embodiments of the invention, in a kind of feedstuff that treats and/or prevents respiratory illness of livestock and poultry provided by the invention, the quality percentage composition of Chinese medicine composition in feedstuff is 0.3～1.0%.
In some embodiments of the invention; In a kind of feedstuff that treats and/or prevents respiratory illness of livestock and poultry provided by the invention, feedstuff comprises a kind of or both the above mixture in Semen sojae atricolor, bean cake, corn, fish flour, aminoacid, the assorted dregs of rice, whey powder, oils and fats, meat meal tankage, corn, the sugar grass.
In some embodiments of the invention; In a kind of feedstuff that treats and/or prevents respiratory illness of livestock and poultry provided by the invention, acceptable additive comprises a kind of or both the above mixture in aminoacid, polysaccharide, oligosaccharide, non-protein nitrogen, mineral element, enzyme preparation, microorganism, vitamin, antibiotic, antioxidant, antifungus agent, antiseptic, binding agent, coloring agent, the flavoring agent in the feedstuff.
Wherein, aminoacid comprises N-methylol Methionine calcium salt., methionine hydroxy analog, L-lysine, L-threonine, L-tryptophan, L-arginine, glycine, L-alanine, valine, cystine etc.
Antiseptic comprises formic acid, formates, propanoic acid, propionate, butanoic acid, butyrate, benzoic acid, benzoate, sorbic acid, sorbate, fumaric acid, citric acid, citrate, tartaric acid etc.
Non-protein nitrogen comprises carbamide, ammonium bicarbonate, ammonium sulfate, Ammonium biphosphate, diammonium phosphate, urea phosphate, Butylated hydroxyanisole (BHA), dibenzylatiooluene (BHT), propyl gallate etc.
Mineral element comprises sodium chloride, dicalcium phosphate, tricalcium phosphate, calcium lactate, magnesium sulfate, magnesium oxide, magnesium chloride, ferrous citrate, ferrous fumarate, ferrous lactate, ferrous sulfate, sodium sulfate, ferrous chloride, iron chloride, ferrous carbonate, copper chloride, copper sulfate, zinc chloride, manganese chloride, potassium iodide, copper lysine complex, copper methionine complex, yeast copper, yeast iron, yeast selenium etc.
Enzyme preparation comprises amylose enzyme (originating from acidolysis amylopectin bacillus cereus), amylase, alpha-galactosidase (originating from aspergillus niger), cellulase, 1,4 beta-glucanase, glucoseoxidase, lipase, maltase, mannase, pectase, phytase, protease, xylanase etc.
Microorganism comprises Lactobacillus bulgaricus, Bacillus licheniformis, bacillus subtilis, not tally bifidus bacillus, lactoenterococcus, bacillus acidophilus, lactobacillus casei, lactobacillus lactis, pediococcus acidilactici, Pediococcus pentosaceus, Candida utilis, saccharomyces cerevisiae, Rhodopseudomonas palustris etc.
Vitamin comprises vitamin A, beta-carotene, thiamine hydrochloride, thiamine mononitrate, riboflavin, pyridoxine hydrochloride, cobalamin, L-ascorbic acid, alpha-tocopherol, menadione sodium bisulfite, hydrochloric acid, D-panthenol, folic acid, D-biotin, choline chloride, inositol, L-carnitine etc.
Binding agent comprises alphalise starch, tri-chlorination two aluminum, edible fatty acid calcium salt, calcium silicates, sodium aluminosilicate, calcium sulfate, calcium stearate, fatty acid glyceride, lecithin, sodium alginate, xanthan gum, lignosulfonates, sodium carboxymethyl cellulose, sorbitan carboxylic esters etc.
Coloring agent comprises astaxanthin, beta-carotene, capsanthin, β-apo--8 '-carotenal, phylloxanthin etc.
Flavoring agent comprises that the sweet acid disodium of sodium glutamate, 5 '-inosine monophosphate, 5 '-bird, food are with spice etc.
The invention provides a kind of this Chinese medicine composition of Chinese medicine composition, Chinese medicine preparation and feedstuff that treats and/or prevents respiratory illness of livestock and poultry is processed by Gypsum Fibrosum, Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Fructus Forsythiae, the Rhizoma Anemarrhenae, Radix Platycodonis, Radix Glycyrrhizae.Chinese medicine composition, Chinese medicine preparation and the feedstuff that treats and/or prevents respiratory illness of livestock and poultry provided by the invention can depressed lung-energy dispersing, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing, anti-inflammation, human body immunity improving power; Production technology is simple; Cost is low, has no side effect.Can the various respiratory system diseases of prophylactic treatment poultry, the enhancing body resistance reduces livestock and poultry and takes place, and improves animal products output.
The specific embodiment
The invention discloses a kind of Chinese medicine composition, Chinese medicine preparation and feedstuff that treats and/or prevents respiratory illness of livestock and poultry, those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is that all similarly replace and change apparent to those skilled in the art, they all are regarded as and are included in the present invention.Method of the present invention and application are described through preferred embodiment; The related personnel obviously can change or suitably change and combination methods and applications as herein described in not breaking away from content of the present invention, spirit and scope, realizes and use technology of the present invention.
Raw materials usedly in Chinese medicine composition, Chinese medicine preparation and the feedstuff that treats and/or prevents respiratory illness of livestock and poultry provided by the invention all can buy by market.
Below in conjunction with embodiment, further set forth the present invention:
The preparation of embodiment 1 Chinese medicine composition
Gypsum Fibrosum 200g, Flos Lonicerae 100g, Radix Isatidis 180g, Radix Scutellariae 180g, Fructus Forsythiae 110g, Rhizoma Anemarrhenae 80g, Radix Platycodonis 100g, Radix Glycyrrhizae 25g.
After 200 orders are pulverized, mix, sieving promptly gets.
The preparation of embodiment 2 Chinese medicine compositions
Gypsum Fibrosum 400g, Flos Lonicerae 200g, Radix Isatidis 60g, Radix Scutellariae 120g, Fructus Forsythiae 100g, Rhizoma Anemarrhenae 40g, Radix Platycodonis 120g, Radix Glycyrrhizae 50g.
After 100 orders are pulverized, mix, sieving promptly gets.
The preparation of embodiment 3 Chinese medicine compositions
Gypsum Fibrosum 300g, Flos Lonicerae 150g, Radix Isatidis 120g, Radix Scutellariae 60g, Fructus Forsythiae 150g, Rhizoma Anemarrhenae 120g, Radix Platycodonis 80g, Radix Glycyrrhizae 75g.
After 30 orders are pulverized, mix, sieving promptly gets.
The preparation of embodiment 4 Chinese medicine compositions
Gypsum Fibrosum 380g, Flos Lonicerae 50g, Radix Isatidis 150g, Radix Scutellariae 140g, Fructus Forsythiae 50g, Rhizoma Anemarrhenae 65g, Radix Platycodonis 40g, Radix Glycyrrhizae 60g.
After 120 orders are pulverized, mix, sieving promptly gets.
The preparation of embodiment 5 Chinese medicine preparation
Get the Chinese medicine composition that embodiment 1 makes, add conventional adjuvant, make powder.
The preparation of embodiment 6 Chinese medicine preparation
Get the Chinese medicine composition that embodiment 2 makes, add conventional adjuvant, make water solube powder.
The preparation of embodiment 7 Chinese medicine preparation
Get the Chinese medicine composition that embodiment 3 makes, add conventional adjuvant, make solution.
The preparation of embodiment 8 Chinese medicine preparation
Get the Chinese medicine composition that embodiment 4 makes, add conventional adjuvant, make injection.
The preparation of embodiment 9 Chinese medicine preparation
Get the Chinese medicine composition that embodiment 1 makes, add conventional adjuvant, make tablet.
The preparation of embodiment 10 feedstuffs
Get the Chinese medicine composition that embodiment 1 makes, add conventional feed raw material such as Semen sojae atricolor, bean cake, corn, fish flour, aminoacid, the assorted dregs of rice, whey powder, oils and fats, meat meal tankage, corn, sugar grass; And the conventional feed additive, like aminoacid, polysaccharide, oligosaccharide, non-protein nitrogen, mineral element, enzyme preparation, microorganism, vitamin, antibiotic, antioxidant, antifungus agent, antiseptic, binding agent, coloring agent, flavoring agent.Wherein, the Chinese medicine composition that makes of embodiment 1 accounts for 0.3% of quality in the feedstuff.
The preparation of embodiment 11 feedstuffs
Get the Chinese medicine composition that embodiment 2 makes, add conventional feed raw material such as Semen sojae atricolor, bean cake, corn, fish flour, aminoacid, the assorted dregs of rice, whey powder, oils and fats, meat meal tankage, corn, sugar grass; And the conventional feed additive, like aminoacid, polysaccharide, oligosaccharide, non-protein nitrogen, mineral element, enzyme preparation, microorganism, vitamin, antibiotic, antioxidant, antifungus agent, antiseptic, binding agent, coloring agent, flavoring agent.Wherein, the Chinese medicine composition that makes of embodiment 2 accounts for 1.0% of quality in the feedstuff.
The preparation of embodiment 12 feedstuffs
Get the Chinese medicine composition that embodiment 3 makes, add conventional feed raw material such as Semen sojae atricolor, bean cake, corn, fish flour, aminoacid, the assorted dregs of rice, whey powder, oils and fats, meat meal tankage, corn, sugar grass; And the conventional feed additive, like aminoacid, polysaccharide, oligosaccharide, non-protein nitrogen, mineral element, enzyme preparation, microorganism, vitamin, antibiotic, antioxidant, antifungus agent, antiseptic, binding agent, coloring agent, flavoring agent.Wherein, the Chinese medicine composition that makes of embodiment 3 accounts for 0.8% of quality in the feedstuff.
The preparation of embodiment 13 feedstuffs
Get the Chinese medicine composition that embodiment 4 makes, add conventional feed raw material such as Semen sojae atricolor, bean cake, corn, fish flour, aminoacid, the assorted dregs of rice, whey powder, oils and fats, meat meal tankage, corn, sugar grass; And the conventional feed additive, like aminoacid, polysaccharide, oligosaccharide, non-protein nitrogen, mineral element, enzyme preparation, microorganism, vitamin, antibiotic, antioxidant, antifungus agent, antiseptic, binding agent, coloring agent, flavoring agent.Wherein, the Chinese medicine composition that makes of embodiment 4 accounts for 0.5% of quality in the feedstuff.
Embodiment 14 culture experiments
Luoyang, Henan raiser raises 5000 15 aa broiler chicken, respiratory symptom occurs, dead 30 of every day; Respiratory symptoms such as the sound of significantly stridulating, cough are arranged; Occur individually shedding tears, rhinorrhea, the swelling of one-sided face.Cut open the inspection symptom serious airsacculitis, perihepatitis, pericarditis are arranged; After face cut off at the swelling position, subcutaneous had a yellow cheese thing.Treatment: the Chinese medicine composition that embodiment 1 makes, after three days, dead 3, respiratory symptom obviously alleviates by the use of explanation amount, and mental symptom is clearly better; Return to one's perfect health after five days, zero death, material feeding drinking-water recovers normal.
Embodiment 15 culture experiments
Lianyun Harbour, Jiangsu raiser raises 10000 of laying hens, 60 age in days generation respiratory tract disease, and after the treatment of local veterinary department, respiratory symptom alleviates, but fails to cure; Still have respiratory symptom until 180 ages in days, chicken crowd growth and development state is starkly lower than the healthy chicken flock with age in days.The Chinese medicine composition 0.3% that this chicken crowd uses embodiment 2 to make during 180 ages in days adds in feedstuff, and after five days, respiratory symptom thoroughly disappears, and spirit is clearly better, and the amount of drinking water of searching for food increases, and it is normal that the chicken crowd recovers.
Embodiment 16 culture experiments
Dehui, Jilin one raiser raises 8000 broiler, occurs cough, ataxia during 25 ages in days, stretches the neck mouth breathing, and swollen head is shed tears, and spirit is depressed, and the feather pine is random, symptoms such as loss of appetite; Cut open the visible tracheal bronchus mucosa swelling of inspection, wall thickening has mucus or cheesy thing in the tube chamber, and airbag wall is slightly plump, the muddiness that is white in color or cheesy thing is arranged, the kidney enlargement.The Chinese medicine composition 1.0% that uses the embodiment of the invention 3 to provide adds in feedstuff, and symptom obviously alleviates after 3 days, returns to one's perfect health after 5 days.
Embodiment 17 culture experiments
Yuncheng, Shanxi one raiser raises 5000 50 ages in days of laying hen, and the winter in 2010 is because of change in weather, symptom such as cough, ataxia, sneeze appear in the chicken crowd, shed tears.The Chinese medicine composition that uses the embodiment of the invention 4 to provide adds symptom complete obiteration after three days in feedstuff by 0.5%.
The above only is a preferred implementation of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention; Can also make some improvement and retouching, these improvement and retouching also should be regarded as protection scope of the present invention.
Claims (10)
1. a Chinese medicine composition that treats and/or prevents respiratory illness of livestock and poultry is characterized in that, is processed by following parts by weight of component:
Gypsum Fibrosum 200～400 weight portions, Flos Lonicerae 50～200 weight portions, Radix Isatidis 60～180 weight portions, Radix Scutellariae 60～180 weight portions, Fructus Forsythiae 50～150 weight portions, the Rhizoma Anemarrhenae 40～120 weight portions, Radix Platycodonis 40～120 weight portions, Radix Glycyrrhizae 25～75 weight portions.
2. Chinese medicine composition according to claim 1 is characterized in that, it is processed by following parts by weight of component:
Gypsum Fibrosum 200～380 weight portions, Flos Lonicerae 50～150 weight portions, Radix Isatidis 120～150 weight portions, Radix Scutellariae 120～140 weight portions, Fructus Forsythiae 50～110 weight portions, the Rhizoma Anemarrhenae 65～120 weight portions, Radix Platycodonis 80～100 weight portions, Radix Glycyrrhizae 25～60 weight portions.
3. Chinese medicine composition according to claim 1 is characterized in that, it is processed by following parts by weight of component:
Gypsum Fibrosum 300 weight portions, Flos Lonicerae 150 weight portions, Radix Isatidis 120 weight portions, Radix Scutellariae 120 weight portions, Fructus Forsythiae 100 weight portions, the Rhizoma Anemarrhenae 80 weight portions, Radix Platycodonis 80 weight portions, Radix Glycyrrhizae 50 weight portions.
4. a method for preparing that treats and/or prevents the Chinese medicine composition of respiratory illness of livestock and poultry is characterized in that, raw material is made up of following parts by weight of component:
Gypsum Fibrosum 200～400 weight portions, Flos Lonicerae 50～200 weight portions, Radix Isatidis 60～180 weight portions, Radix Scutellariae 60～180 weight portions, Fructus Forsythiae 50～150 weight portions, the Rhizoma Anemarrhenae 40～120 weight portions, Radix Platycodonis 40～120 weight portions, Radix Glycyrrhizae 25～75 weight portions;
Said raw material mixes, sieving promptly gets after 30～200 orders are pulverized.
5. method for preparing according to claim 4 is characterized in that, said raw material is processed by following parts by weight of component:
Gypsum Fibrosum 200～380 weight portions, Flos Lonicerae 50～150 weight portions, Radix Isatidis 120～150 weight portions, Radix Scutellariae 120～140 weight portions, Fructus Forsythiae 50～110 weight portions, the Rhizoma Anemarrhenae 65～120 weight portions, Radix Platycodonis 80～100 weight portions, Radix Glycyrrhizae 25～60 weight portions.
6. method for preparing according to claim 4 is characterized in that, said raw material is processed by following parts by weight of component:
Gypsum Fibrosum 300 weight portions, Flos Lonicerae 150 weight portions, Radix Isatidis 120 weight portions, Radix Scutellariae 120 weight portions, Fructus Forsythiae 100 weight portions, the Rhizoma Anemarrhenae 80 weight portions, Radix Platycodonis 80 weight portions, Radix Glycyrrhizae 50 weight portions.
7. a feedstuff that improves poultry feed intake and feed conversion rate is characterized in that, is made up of acceptable additive in Chinese medicine composition according to claim 1, feedstuff and the feedstuff.
8. feedstuff according to claim 7 is characterized in that, the quality percentage composition of said Chinese medicine composition in feedstuff is 0.3～1.0%.
9. feedstuff according to claim 7 is characterized in that, said feedstuff comprises a kind of or both the above mixture in Semen sojae atricolor, bean cake, corn, fish flour, aminoacid, the assorted dregs of rice, whey powder, oils and fats, meat meal tankage, corn, the sugar grass.
10. feedstuff according to claim 7; It is characterized in that acceptable additive comprises a kind of or both the above mixture in aminoacid, polysaccharide, oligosaccharide, non-protein nitrogen, mineral element, enzyme preparation, microorganism, vitamin, antibiotic, antioxidant, antifungus agent, antiseptic, binding agent, coloring agent, the flavoring agent in the said feedstuff.
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