CN104474082A - Traditional Chinese medicine composition for preventing and treating piglet diarrhea and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating piglet diarrhea and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating piglet diarrhea. The composition is prepared from the following components in parts by weight: 6-24 parts of astragalus membranaceus, 6-24 parts of codonopsis pilosula, 6-18 parts of poria cocos, 6-15 parts of rhizoma atractylodis macrocephalae, 6-24 parts of saposhnicovia divaricata, 6-15 parts of semen lablab album, 6-15 parts of agastache rugosa, 9-15 parts of medicated leaven, 6-15 parts of hawthorn, 6-24 parts of coptis chinensis, 6-18 parts of lonicera japonica, 9-36 parts of fructus forsythiae, 6-18 parts of scutellaria baicalensis, 6-24 parts of folium isatidis, 6-15 parts of pericarpium citri reticulatae and 3-10 parts of oligopolyose. The traditional Chinese medicine composition contains multiple bioactive substances, such as polysaccharide, alkaloids, saponins, organic acid and the like, can be used for treating both symptoms and root causes of piglet diarrhea, can be used for improving body resistance, improving body immunity by tonifying middle jiao, tonifying qi, regulating qi circulation, promoting blood circulation, strengthening spleen, drying dampness, nourishing stomach and eliminating stagnation, can be used for regulating the micro-ecological environment of intestinal tracts and controlling piglet diarrhea, and has the effects of producing piglet growth and improving the rate of feed return.
Description
Technical field
The present invention relates to a kind of herbal medicine, specifically a kind of Chinese medicine composition preventing and treating piglet diarrhea and preparation method thereof.
Background technology
Piglet diarrhea is a kind of commonly encountered diseases and the frequently-occurring disease of pig, and this disease all has generation throughout the year, especially more with winter-spring season morbidity.Affected pig main manifestations is vomiting, diarrhoea, draws white or light yellow loose stool, and with symptoms such as heating, cough, rhinorrhea, serious symptom affected pig is then dewatered rapidly, and body weight obviously declines, and has a strong impact on the growth promoter of pig, after particularly piglet suffers from diarrhoea, have a strong impact on the survival rate of piglet.
Piglet diarrhea is the typical multifactor property disease of the one under intensive pig production working condition, and being one of at present the most serious piglet diseases group, is also the major reason causing piglet death, and according to investigations, piglet accounts for 39.8% of the dead sum of piglet because of death of suffering from diarrhoea; The piglet of below 30kg, average of the whole year sickness rate 46.5%, mortality rate 10.3%.
Piglet diarrhea ranks first in pig industry harm, and the sound development of pig industry in serious threat, causes that price of deed rate is lower, piglet survival ratio declines, poor growth, growth promoter stagnate (i.e. so-called cad pig), even death.In recent years, rapid to the antibiosis class drug development for the treatment of piglet diarrhoea, and be widely used in veterinary clinic, the dosage of use is also increasing, and Resistant strain also increases gradually, causes many unfavorable factors to this disease of clinical treatment.Selecting to have wide spectrum, antimicrbial power and by force, not easily produce drug resistance, medicine that toxic and side effects is little, is the anxious problem waiting to need to solve of veterinary circle.Therefore the research of Chinese medicine preparation for treating piglet diarrhea is more and more paid attention to.
Piglet is because not yet setting up stable microecosystem in intestinal, and self-resistance is lower, stimulates sensitivity to external world, is subject to the invasion and attack of various pathogenic microorganism and the impact of various stressors.Suckling pig is comparatively common with infectious diarrhea, and the diarrhoea that the non-pathogenic factors such as child care piglet is irritated based on daily ration antigen, wean, feedstuff are changed suddenly, cold, environmental stress cause.Relation between this two classes factor is very close, both influences each other, again reciprocal causation, and normal is multiple infection or the mixed infection that intersects.
In order to control primary disease, generally adopt antibiotic, antiviral agents, hormone, chemical synthetic drug clinically, or in feedstuff, add these medicines carry out treating and alleviating diarrhoea, but the life-time service of these materials can make pathogenic microorganism produce drug resistance, the cost of cultivation is increased, and the prevention and control difficulty of disease strengthens.In addition, these medicines use in a large number and not only cause livestock products drug residue, cause increasing environmental pollution, compromise the health of mankind itself, but also have impact on outlet, cause far-reaching political fallout and serious economic loss to the Chinese government.
Summary of the invention
The object of this invention is to provide one and can prevent diarrhea of weaned piglets, there is again promotion piglet growth, improve the Chinese medicine composition of the control piglet diarrhea of price of deed rate.
The present invention realizes above-mentioned purpose by the following technical solutions: a kind of Chinese medicine composition preventing and treating piglet diarrhea, is prepared from by each component of following weight portion: the Radix Astragali 6 ~ 24 parts, Radix Codonopsis 6 ~ 24 parts, 6 ~ 18 parts, Poria, the Rhizoma Atractylodis Macrocephalae 6 ~ 15 parts, Radix Saposhnikoviae 6 ~ 24 parts, Semen Lablab Album 6 ~ 15 parts, Herba Pogostemonis 6 ~ 15 parts, Massa Medicata Fermentata 9 ~ 15 parts, Fructus Crataegi 6 ~ 15 parts, Rhizoma Coptidis 6 ~ 24 parts, Flos Lonicerae 6 ~ 18 parts, Fructus Forsythiae 9 ~ 36 parts, Radix Scutellariae 6 ~ 18 parts, Folium Isatidis 6 ~ 24 parts, Pericarpium Citri Reticulatae 6 ~ 15 parts, few polysaccharide 3 ~ 10 parts.
Prevent and treat a Chinese medicine composition for piglet diarrhea, be prepared from by each component of following weight portion: the Radix Astragali 12 parts, Radix Codonopsis 9 parts, 9 parts, Poria, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Saposhnikoviae 12 parts, Semen Lablab Album 6 parts, Herba Pogostemonis 12 parts, Massa Medicata Fermentata 9 parts, Fructus Crataegi 12 parts, Rhizoma Coptidis 9 parts, Flos Lonicerae 9 parts, Fructus Forsythiae 18 parts, Radix Scutellariae 9 parts, Folium Isatidis 12 parts, Pericarpium Citri Reticulatae 6 parts, few polysaccharide 5 parts.
Its dosage form is powder.
Prevent and treat a preparation method for the Chinese medicine composition of piglet diarrhea, first take each raw material of Chinese medicine, cross 40-80 mesh sieve after pulverizing, then add few polysaccharide, be placed in mixer and stir, fully mix, pulverize finally by superfine communication technique, make superfine powder.
The Radix Astragali: property is sweet, warm; Return lung, spleen channel.Have and strengthen immune system, slow down aging.Antioxidation, enhancing cardiovascular system, antithrombotic, antitumor, mutation, anti-stress, antioxidation, slow down aging promote the effects such as anabolism, antiinflammatory and analgesia; Benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening; Cure mainly the card of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle difficulty is burst or is burst for a long time and do not hold back.
Radix Codonopsis: property is sweet, flat; Return spleen, lung meridian.There is the effects such as enhancing body stress ability, enhancing human body immunity function, slow down aging, antiulcer, enhancing cardiovascular system; Strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid; Cure mainly weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung is breathed with cough, spontaneous perspiration of breathing hard, deficiency of both QI and blood etc.
Poria: property is sweet, light, flat; GUIXIN, spleen, lung, kidney channel.There is the effects such as diuresis, anticancer, immunostimulant; Promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming; Cure mainly dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, has loose bowels.
The Rhizoma Atractylodis Macrocephalae: warm in nature, bitter in the mouth and be with sweet.Return taste warp, there is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, the effect such as antiabortive.Have tranquilizing soporific, blood pressure lowering, expansion peripheral blood vessel, anticoagulation, antithrombotic, anti-gastric injury, anti-gastric-ulcer, protect the liver, function of gallbladder promoting, diuresis, blood sugar lowering, immunomodulating, antibacterium, antifungal, antitumor, antioxidation etc.
Radix Saposhnikoviae: warm in nature, acrid in the mouth, sweet.Return bladder, liver, spleen channel.The functions such as Radix Saposhnikoviae has inducing diaphoresis to dispel wind, and victory is wet, antipruritic, relieving convulsion, tranquilizing soporific, convulsion, calm, antipyretic, cooling, anticoagulation, antithrombotic suppresses smooth muscle, spasmolytic, immunomodulating, antiinflammatory, antiallergic, antihistamine, the pharmacological actions such as antibacterium.
Semen Lablab Album: slightly warm in nature, sweet in the mouth.There is invigorating the spleen for eliminating dampness, and in relieve summer heat.For weakness of the spleen and stomach, inappetence, large more half congealedly to rush down, leukorrhagia, heat-damp in summer are vomited and diarrhoea, abdominal distention uncomfortable in chest.Modern pharmacology Effect study shows the effect having enhancing human body immunity function, has inhibitory action to dysentery bacterium, has Detoxication to the vomiting, acute gastroenteritis etc. that alimentary toxicosis causes.
Herba Pogostemonis: nature and flavor are pungent, tepor, return spleen, stomach, lung meridian.Herba Pogostemonis have deliver expelling summer-heat, removing dampness is amusing, the effect of the preventing or arresting vomiting that whets the appetite.Herba Pogostemonis has the effect delivering expelling summer-heat, the nausea and vomiting that treatment sunstroke in summer causes, sweating, and faint, Herba Pogostemonis has the effect delivering expelling summer-heat, the nausea and vomiting that treatment sunstroke in summer causes, and sweating, faints, have good effect.Herba Pogostemonis can also treat the diseases such as energy-stagnation stomachache, has adjustment gastrointestinal function, promotes gastric secretion, strengthens the effect of eupepsy.For flatulence, have a stomach-ache, anorexia, having the hiccups after meal etc. has good pleasant analgesic effect.Herba Pogostemonis also has effect of antidiarrheal to have good curative effect for the abdominal pain diarrhea that enteritis, heatstroke, eating and drinking without temperance cause.Also can be used for the abdominal distention diarrhoea that alimentary toxicosis causes.Also can be used for malaria, dysentery.Its water decoction in vitro has stronger Fungistasis and antibacterial action.
Massa Medicata Fermentata: property sweet, acrid, warm.Return spleen, stomach through having invigorating the spleen and regulating the stomach, the effect of promoting digestion and removing stagnation.Main retention of food and drink, dyspepsia, gastral cavity tripe distension, is off one's feed, vomiting dysentery.Include the compositions such as vitamin B complex, enzyme, ergosterol and protein because of Massa Medicata Fermentata, therefore by oxidation energy supply, promote human body digesting and assimilating and utilizing food protein.
Fructus Crataegi: property is sour, sweet, tepor; Return spleen, stomach, Liver Channel.There is the effects such as digestion promoting, blood pressure lowering, blood fat reducing, antioxidation; Promoting digestion and invigorating the stomach, circulation of qi promoting scattered silt; Cure mainly eating accumulation, abdominal distention, dysentery etc.
Rhizoma Coptidis: cold in nature, bitter in the mouth, enters the heart, liver, gallbladder, stomach, large intestine channel.There is heat clearing and damp drying, eliminating fire and detoxication, bowel relieving antidiarrheal, effect of suppressing the hyperactive liver improving eyesight.Modern pharmacological research is thought: 1, have broad-spectrum antibacterial action; Anti-bacteria, fungus, virus, fungus, protozoacide; 2, antidiarrheal, stomach invigorating, improves gastric juice, bile secretion, promotes gastrointestinal motility; 3, function of gallbladder promoting, increases bile and is formed and promote bilirubin excretion; 4, immunomodulating, has suppression to leukaemia, antiplatelet aggregation.
Flos Lonicerae: sweet in flavor and cold in property, returns lung, the heart, stomach warp; The effects such as Flos Lonicerae has heat-clearing and toxic substances removing, heat radiation dispelling wind.This product tool broad-spectrum antibacterial action, to staphylococcus aureus, Staphylococcus albus, first, beta hemolytic streptococcus, the gram positive bacterias such as Diplococcus pneumoniae have inhibitory action; Also stronger inhibitory action is had to gram negative bacterias such as dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, bacillus pyocyaneus, escherichia coli, meningococcus.Its antibacterial strength is to be the strongest to golden yellow Portugal color grape coccus, and bacillus pyocyaneus, escherichia coli take second place.If share with antibiotic and Radix Scutellariae etc., can fungistatic effect be improved, reduce the generation of Resistant strain.To Respirovirus as Asia influenza A virus, Orphan virus have inhibitory action, and can suppress and delay its cytopathogenic effect.For influenza, enteritis, dysentery, meningitis, pneumonia, mastitis and infectious fever and traumatic infection etc.
Fructus Forsythiae: cold nature, bitter in the mouth, returns lung, the heart, small intestine meridian; There is heat-clearing and toxic substances removing, effect of dispersing swelling and dissipating binds.Fructus Forsythiae or its volatile oil, forsythol tool broad-spectrum antibacterial action, all have inhibitory action to multiple Gram-positive and negative bacteria.As staphylococcus aureus, Diplococcus pneumoniae, Hemolytic streptococcus, dysentery bacterium, history Shigella flexneri, ' bacillus pestis, Bacillus typhi, vibrio cholera, Salmonella paratyphi, Bacillus proteus, escherichia coli, star nocardia etc.; Inhibitory action is had to Asia influenza A virus, rhinovirus 1 type etc.Swell for influenza, pneumonia, enteritis, epizootic lymphangitis, breast epidemic disease and skin ulcer.
Radix Scutellariae: cold in nature, bitter in the mouth, returns lung, gallbladder, spleen, large intestine, small intestine meridian; There is heat clearing and damp drying, eliminating fire and detoxication, effect of arresting bleeding and miscarriage prevention.This product tool broad-spectrum antibacterial action, all have bacteriostasis to alpha streptococcus, streptococcus pneumoniae, meningococcus, staphylococcus aureus, diphtheria corynebacterium, vibrio cholera, dysentery bacterium, cattle and sheep pig three type brucella, bacillus pyocyaneus, white scour of chicken bacillus etc., especially to staphylococcus and bacillus pyocyaneus inhibitory action stronger.Also there is inhibitory action to some pathogenic fungus, virus, also have inhibitory or killing effect to leptospira, protozoon etc.Swell for enteritis, pneumonia, brucellosis, influenza, endometritis, conjunctivitis, ophthalmia and inflammation.Also the preventive drug of the white scour of chicken can be used as.This product have protect the liver, function of gallbladder promoting, and antiinflammatory, antiallergic, diuresis, calmness, the blood pressure lowering of expansion peripheral blood vessel spoke effect, burnt suppression platelet aggregation.Due to this product bitter in the mouth, also there is digestion promoting function, for jaundice, hepatitis and dyspepsia etc.
Folium Isatidis: cold in nature, bitter in the mouth.There is heat-clearing and toxic substances removing, cooling blood for hemostasis, effect of speckle removing.Main fever caused by exogenous pathogenic factors intenseness of heat excessive thirst, laryngopharynx swelling and pain, aphtha, jaundice, pyrotoxic dysentery, acute enteritis, swollen ulcer drug, epistaxis, stranguria with blood, traumatic hemorrhage.Folium Isatidis modern pharmacology shows; 1. the in vitro tests of Folium Isatidis decoct has certain inhibitory action to staphylococcus aureus, alpha streptococcus, meningococcus, streptococcus pneumoniae, micrococcus catarrhalis, Bacillus typhi, escherichia coli, hemophilus influenza, diphtheria corynebacterium and dysentery bacterium; Folium Isatidis also has inhibitory action to encephalitis b virus, mumps virus, influenza virus etc.In addition Folium Isatidis kills leptospiral effect.2. anti-endotoxin effect: experiment in vivo and vitro shows that Folium Isatidis has the effect of Chinese People's Anti-Japanese Military and Political College enterobacteria O111B4 endotoxin.3. the suppression ratio of indirubin to mouse leukemia L7212 is higher.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship.Return spleen, stomach, lung meridian.Pericarpium Citri Reticulatae has stomach function regulating, stopping nausea and vomiting by lowering the adverse flow of QI, regulates the flow of vital energy, the effects such as drying dampness to eliminate phlegm.Excited heart, expansion coronary vasodilator, atherosclerosis, hemostasis, coagulant blood, suppresses smooth muscle, spasmolytic, anti-gastric-ulcer, and facilitating digestion liquid is secreted, and function of gallbladder promoting, eliminates the phlegm, and relievings asthma, immunomodulating, the pharmacological actions such as antiinflammatory.Volatile oil contained by Pericarpium Citri Reticulatae has gentle stimulation to intestinal, can the secretion of facilitating digestion liquid, gets rid of the pneumatosis in intestinal tube; Zest phlegm-dispelling functions, makes sputum be easy to expectoration simultaneously.Pericarpium Citri Reticulatae effective ingredient Pericarpium Citri Reticulatae glycosides and methyl Pericarpium Citri Reticulatae glycosides all have the effect of Citrin sample, are antiinflammatory, antianaphylactic effective ingredient.This product has inhibitory action to staphylococcus, staphylococcus aureus, bacillus pyocyaneus, shigella flexneri, Bacillus proteus, the infection of hesperidin energy flu-prevention virus.
In this Chinese medicine composition prescription disclosed by the invention, Radix Codonopsis, Radix Astragali invigorating the spleen and replenishing QI spleen invigorating are monarch drug; Poria, Rhizoma Atractylodis Macrocephalae spleen invigorating eliminating dampness and diuresis; Herba Pogostemonis, Semen Lablab Album invigorating the spleen for eliminating dampness, be longer than antidiarrheal; Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Rhizoma Coptidis, Radix Scutellariae heat-clearing and toxic substances removing, dampness-eliminating and dysentery-stopping; Pericarpium Citri Reticulatae is regulated the flow of vital energy; Massa Medicata Fermentata, hawthorn digesting Regulating the stomach and removing stagnated food, make stagnant disappearing and easily only rush down, altogether for assistant makes.
Containing various bioactivators such as polysaccharide, alkaloid, Saponin and organic acid in Chinese medicine composition disclosed by the invention, treating both the principal and secondary aspects of a disease in treatment piglet diarrhea, transfer body each side factor, improve the resistance of body, improve immunity of organisms by invigorating the spleen and replenishing QI, vital energy regualting and blood circulation-promoting, heat-clearing and toxic substances removing, effective suppression or kill pathogen, spleen invigorating dehumidifies, and nourishing the stomachization is stagnant, conditioning intestine microenvironment, Comprehensive Control piglet diarrhea; Except preventing diarrhea of weaned piglets, also having and promoting piglet growth effect, improve effect of price of deed rate.The present invention is according to Chinese veterinarian's pharmacology opinion and practical experience, dialectical caused by Shi Re Bing Pian to piglet diarrhea.Damp and hot upper steaming, spirit is depressed; Stomach-QI being unable to descend normally, therefore vomit; Damp and hot criminal's spleen, then loss of appetite; Damp and hot tenesmus, intestinal conduction dereliction of duty, water is wet can not divide profit, therefore rushes down as note, and feces is smelt as of rotten fish, and short urination is few; Interior intenseness of heat, happiness is drunk water.Therefore with heat-clearing and toxic substances removing, stomach invigorating is amusing, eliminating turbid pathogen with aromatics, dehumidifying dysentery relieving is the rule for the treatment of; Be aided with invigorating the spleen and replenishing QI, vital energy regualting and blood circulation-promoting, strengthening the spleen and nourishing the stomach, change are stagnant, the conditioning aspect such as intestine microenvironment, enhancing immunity prescription controls piglet diarrhea.
Detailed description of the invention
Embodiment 1
Prevent and treat a Chinese medicine composition for piglet diarrhea, be prepared from by each component of following weight portion: the Radix Astragali 12 parts, Radix Codonopsis 9 parts, 9 parts, Poria, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Saposhnikoviae 12 parts, Semen Lablab Album 6 parts, Herba Pogostemonis 12 parts, Massa Medicata Fermentata 9 parts, Fructus Crataegi 12 parts, Rhizoma Coptidis 9 parts, Flos Lonicerae 9 parts, Fructus Forsythiae 18 parts, Radix Scutellariae 9 parts, Folium Isatidis 12 parts, Pericarpium Citri Reticulatae 6 parts, few polysaccharide 5 parts.
The preparation method of this Chinese powder medicine is: take each raw material of Chinese medicine, crosses 80 mesh sieves, then add few polysaccharide, be placed in mixer and stir, fully mix after pulverizing, and pulverizes, make superfine powder, subpackage, obtain finished product finally by superfine communication technique.
The usage of this Chinese medicine composition and consumption: add this Chinese medicine composition 500g in every 100kg feedstuff, be used in conjunction 5 ~ 7 days.
Embodiment 2
Prevent and treat a Chinese medicine composition for piglet diarrhea, be prepared from by each component of following weight portion: the Radix Astragali 6 parts, Radix Codonopsis 6 parts, 6 parts, Poria, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Saposhnikoviae 6 parts, Semen Lablab Album 9 parts, Herba Pogostemonis 9 parts, Massa Medicata Fermentata 10 parts, Fructus Crataegi 9 parts, Rhizoma Coptidis 6 parts, Flos Lonicerae 6 parts, Fructus Forsythiae 21 parts, Radix Scutellariae 6 parts, Folium Isatidis 9 parts, Pericarpium Citri Reticulatae 12 parts, few polysaccharide 3 parts.
The preparation method of this Chinese powder medicine is: take each raw material of Chinese medicine, crosses 40 mesh sieves, then add few polysaccharide, be placed in mixer and stir, fully mix after pulverizing, and pulverizes, make superfine powder, subpackage, obtain finished product finally by superfine communication technique.
The usage of this Chinese medicine composition and consumption: add this Chinese medicine composition 500g in every 100kg feedstuff, be used in conjunction 5 ~ 7 days.
Embodiment 3
Prevent and treat a Chinese medicine composition for piglet diarrhea, be prepared from by the component of following parts by weight: the Radix Astragali 18 parts, Radix Codonopsis 15 parts, 12 parts, Poria, the Rhizoma Atractylodis Macrocephalae 11 parts, Radix Saposhnikoviae 24 parts, Semen Lablab Album 15 parts, Herba Pogostemonis 15 parts, Massa Medicata Fermentata 15 parts, Fructus Crataegi 15 parts, Rhizoma Coptidis 12 parts, Flos Lonicerae 12 parts, Fructus Forsythiae 24 parts, Radix Scutellariae 12 parts, Folium Isatidis 18 parts, Pericarpium Citri Reticulatae 15 parts, few polysaccharide 10 parts.
The preparation method of this Chinese powder medicine is: take each raw material of Chinese medicine, crosses 60 mesh sieves, then add few polysaccharide, be placed in mixer and stir, fully mix after pulverizing, and pulverizes, make superfine powder, subpackage, obtain finished product finally by superfine communication technique.
The usage of this Chinese medicine composition and consumption: add this Chinese medicine composition 500g in every 100kg feedstuff, be used in conjunction 5 ~ 7 days.
Embodiment 4
Prevent and treat a Chinese medicine composition for piglet diarrhea, be prepared from by the component of following parts by weight: the Radix Astragali 24 parts, Radix Codonopsis 18 parts, 15 parts, Poria, the Rhizoma Atractylodis Macrocephalae 6 parts, Radix Saposhnikoviae 18 parts, Semen Lablab Album 8 parts, Herba Pogostemonis 13 parts, Massa Medicata Fermentata 11 parts, Fructus Crataegi 7 parts, Rhizoma Coptidis 18 parts, Flos Lonicerae 15 parts, Fructus Forsythiae 9 parts, Radix Scutellariae 13 parts, Folium Isatidis 15 parts, Pericarpium Citri Reticulatae 9 parts, few polysaccharide 6 parts.
The preparation method of this Chinese powder medicine is: take each raw material of Chinese medicine, crosses 60 mesh sieves, then add few polysaccharide, be placed in mixer and stir, fully mix after pulverizing, and pulverizes, make superfine powder, subpackage, obtain finished product finally by superfine communication technique.
The usage of this Chinese medicine composition and consumption: add this Chinese medicine composition 500g in every 100kg feedstuff, be used in conjunction 5 ~ 7 days.
Embodiment 5
Prevent and treat a Chinese medicine composition for piglet diarrhea, be prepared from by the component of following parts by weight: the Radix Astragali 15 parts, Radix Codonopsis 20 parts, 18 parts, Poria, the Rhizoma Atractylodis Macrocephalae 9 parts, Radix Saposhnikoviae 9 parts, Semen Lablab Album 10 parts, Herba Pogostemonis 6 parts, Massa Medicata Fermentata 12 parts, Fructus Crataegi 6 parts, Rhizoma Coptidis 24 parts, Flos Lonicerae 13 parts, Fructus Forsythiae 36 parts, Radix Scutellariae 15 parts, Folium Isatidis 16 parts, Pericarpium Citri Reticulatae 8 parts, few polysaccharide 8 parts.
The preparation method of this Chinese powder medicine is: take each raw material of Chinese medicine, crosses 80 mesh sieves, then add few polysaccharide, be placed in mixer and stir, fully mix after pulverizing, and pulverizes, make superfine powder, subpackage, obtain finished product finally by superfine communication technique.
The usage of this Chinese medicine composition and consumption: add this Chinese medicine composition 500g in every 100kg feedstuff, be used in conjunction 5 ~ 7 days.
Embodiment 6
Prevent and treat a Chinese medicine composition for piglet diarrhea, be prepared from by the component of following parts by weight: the Radix Astragali 20 parts, Radix Codonopsis 24 parts, 10 parts, Poria, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Saposhnikoviae 21 parts, Semen Lablab Album 13 parts, Herba Pogostemonis 10 parts, Massa Medicata Fermentata 14 parts, Fructus Crataegi 13 parts, Rhizoma Coptidis 15 parts, Flos Lonicerae 18 parts, Fructus Forsythiae 13 parts, Radix Scutellariae 18 parts, Folium Isatidis 24 parts, Pericarpium Citri Reticulatae 11 parts, few polysaccharide 7 parts.
The preparation method of this Chinese powder medicine is: take each raw material of Chinese medicine, crosses 40 mesh sieves, then add few polysaccharide, be placed in mixer and stir, fully mix after pulverizing, and pulverizes, make superfine powder, subpackage, obtain finished product finally by superfine communication technique.
The usage of this Chinese medicine composition and consumption: add this Chinese medicine composition 500g in every 100kg feedstuff, be used in conjunction 5 ~ 7 days.
Use concrete description of test effect of the present invention below:
1 materials and methods
1.1 material
1.1.1 experimental animal
Test pig totally 76, from plant of Zhengzhou Houyi Pharmaceutical Co., Ltd. 8,000, is divided into test I group according to symptom, tests II group, tests III group.
1.1.2 trial drug
By medicine prepared by formula disclosed in embodiment of the present invention 1-6, every 100kg feedstuff adds this product 500g, is used in conjunction 5 ~ 7 days.
1.2 method
1.2.1 piglet diet is tested
Test piglet diet is prepared from Semen Maydis 62%, bean cake 27.3%, wheat bran 7%, calcium hydrogen phosphate 1.4%, stone powder 1%, Sal 0.3%, premix material 1%; Nutrient concentration is: crude protein 18%, digestible energy 13.2MJ/kg, calcium 0.8%, phosphorus 0.4%.
1.2.2 diagnostic method
Piglet shows as borborygmus diarrhea, rushes down lower milky white or greyish white, accompanies lump in breast.Tripe abdominal distention and pain, later turns round and look at abdomen, sucks the breast and reduces, lassitude.In mouthful, acid is smelly, and mouth color is micro-red, and thick fur is greasy, is classified as dyspepsia due to improper feeding and has loose bowels.
Piglet morbidity is comparatively anxious, rushes down lower spouting diarrhea, and rush down tens of day, feces is thin, and yellow skin raw meat is dirty, is sometimes with blood.Borborygmus are suffered from abdominal pain, and generate heat thirsty, and spirit is indifferent, eyes semi-closure, and lips are sagging, very then high heat, restlessness, accelerated breathing, the heart is caught hyperfunction, and urine is short and small, enophthalmos,enophthalmus, cachexia, sleeping ground is difficult to be risen, and dry mouth and tougue, mouth red complexion is red, and yellowish fur or dry burnt hair, be classified as diarrhea due to damp-heat.
With the passing of time piglet diarrhea does not heal, loose stool, is mixed with bubble, or accompanies indigested feedstuff or milk block, and suck the breast and reduce, become thin gradually, refreshing tired power is weary, is reluctant to stand up.Mouth color is in vain light, and thin white fur of tongue or BOHUANG, be classified as diarrhea due to hypofunction of the spleen.
1.2.3 feeding and management
Piglet is raised at nursery house, all piglet labelling overbits, and free choice feeding and drinking-water, regularly clean health, and daily management and inoculation routinely program perform, and test carries out 1 time-of-week altogether.
1.2.4 curative effect judging standard
Treatments period, examines the elasticity of the mental status of each group of sick pig, appetite, stool situation, perianal humidity and anal sphincter every day sooner or later for twice.
Effective: treatment 48 ~ 96h feces character takes a turn for the better, moisture obviously reduces, clinical symptom remission or substantially disappear, is labeled as " * * ".
Effective: treatment 48 ~ 72h feces is strip, and color, abnormal smells from the patient are normal, and piglet spirit, sucking or material feeding are normal, and symptom disappears completely, is labeled as " * ".
Invalid: after treatment 96h, feces number of times and character are without improvement, and even aggravation, is labeled as " _ "
2 result of the tests
The medicine prepared by formula disclosed in embodiment of the present invention 1-6 carries out animal experiment respectively, tests I, II, III group of test situation in Table 1-6.
Table 1
| Group | Head number | Piglet diarrhea type | Effectively (head) | Effective (head) | Invalid (head) | Effective percentage % |
| Test I group | 15 | Dyspepsia due to improper feeding is had loose bowels | 10 | 5 | 0 | 100 |
| Test II group | 15 | Diarrhea due to damp-heat | 8 | 6 | 1 | 93.3 |
| Test II group | 15 | Diarrhea due to hypofunction of the spleen | 8 | 4 | 3 | 80 |
Table 2
| Group | Head number | Piglet diarrhea type | Effectively (head) | Effective (head) | Invalid (head) | Effective percentage % |
| Test I group | 15 | Dyspepsia due to improper feeding is had loose bowels | 9 | 6 | 0 | 100 |
| Test II group | 15 | Diarrhea due to damp-heat | 8 | 5 | 2 | 86.7 |
| Test II group | 15 | Diarrhea due to hypofunction of the spleen | 7 | 4 | 4 | 73.3 |
Table 3
| Group | Head number | Piglet diarrhea type | Effectively (head) | Effective (head) | Invalid (head) | Effective percentage % |
| Test I group | 15 | Dyspepsia due to improper feeding is had loose bowels | 9 | 6 | 0 | 100 |
| Test II group | 15 | Diarrhea due to damp-heat | 7 | 4 | 4 | 73.3 |
| Test II group | 15 | Diarrhea due to hypofunction of the spleen | 8 | 4 | 3 | 80 |
Table 4
| Group | Head number | Piglet diarrhea type | Effectively (head) | Effective (head) | Invalid (head) | Effective percentage % |
| Test I group | 15 | Dyspepsia due to improper feeding is had loose bowels | 9 | 5 | 1 | 93.3 |
| Test II group | 15 | Diarrhea due to damp-heat | 9 | 4 | 2 | 86.7 |
| Test II group | 15 | Diarrhea due to hypofunction of the spleen | 8 | 5 | 2 | 86.7 |
Table 5
| Group | Head number | Piglet diarrhea type | Effectively (head) | Effective (head) | Invalid (head) | Effective percentage % |
| Test I group | 15 | Dyspepsia due to improper feeding is had loose bowels | 9 | 6 | 0 | 100 |
| Test II group | 15 | Diarrhea due to damp-heat | 9 | 4 | 2 | 86.7 |
| Test II group | 15 | Diarrhea due to hypofunction of the spleen | 10 | 3 | 2 | 86.7 |
Table 6
| Group | Head number | Piglet diarrhea type | Effectively (head) | Effective (head) | Invalid (head) | Effective percentage % |
| Test I group | 15 | Dyspepsia due to improper feeding is had loose bowels | 8 | 7 | 0 | 100 |
| Test II group | 15 | Diarrhea due to damp-heat | 7 | 5 | 3 | 80 |
| Test II group | 15 | Diarrhea due to hypofunction of the spleen | 8 | 4 | 3 | 80 |
The above results shows that the Chinese medicine composition of control piglet diarrhea disclosed by the invention has good effect to treatment piglet diarrhea, this Chinese medicine composition is treating both the principal and secondary aspects of a disease in treatment piglet diarrhea, transfer body each side factor, the resistance improving body improves the effects such as immunity of organisms by invigorating the spleen and replenishing QI, vital energy regualting and blood circulation-promoting, heat-clearing and toxic substances removing effectively suppresses or kills pathogen, the aspect Comprehensive Control piglet diarrhea such as spleen invigorating dehumidifies, and nourishing the stomachization is stagnant, conditioning intestine microenvironment.
Claims (4)
1. prevent and treat the Chinese medicine composition of piglet diarrhea for one kind, it is characterized in that, be prepared from by each component of following weight portion: the Radix Astragali 6 ~ 24 parts, Radix Codonopsis 6 ~ 24 parts, 6 ~ 18 parts, Poria, the Rhizoma Atractylodis Macrocephalae 6 ~ 15 parts, Radix Saposhnikoviae 6 ~ 24 parts, Semen Lablab Album 6 ~ 15 parts, Herba Pogostemonis 6 ~ 15 parts, Massa Medicata Fermentata 9 ~ 15 parts, Fructus Crataegi 6 ~ 15 parts, Rhizoma Coptidis 6 ~ 24 parts, Flos Lonicerae 6 ~ 18 parts, Fructus Forsythiae 9 ~ 36 parts, Radix Scutellariae 6 ~ 18 parts, Folium Isatidis 6 ~ 24 parts, Pericarpium Citri Reticulatae 6 ~ 15 parts, few polysaccharide 3 ~ 10 parts.
2. a kind of Chinese medicine composition preventing and treating piglet diarrhea according to claim 1, it is characterized in that, be prepared from by each component of following weight portion: the Radix Astragali 12 parts, Radix Codonopsis 9 parts, 9 parts, Poria, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Saposhnikoviae 12 parts, Semen Lablab Album 6 parts, Herba Pogostemonis 12 parts, Massa Medicata Fermentata 9 parts, Fructus Crataegi 12 parts, Rhizoma Coptidis 9 parts, Flos Lonicerae 9 parts, Fructus Forsythiae 18 parts, Radix Scutellariae 9 parts, Folium Isatidis 12 parts, Pericarpium Citri Reticulatae 6 parts, few polysaccharide 5 parts.
3. a kind of Chinese medicine composition preventing and treating piglet diarrhea according to claim 1 and 2, is characterized in that: its dosage form is powder.
4. a kind of preparation method of preventing and treating the Chinese medicine composition of piglet diarrhea as claimed in claim 1, is characterized in that first taking each raw material of Chinese medicine, crosses 40-80 mesh sieve after pulverizing, then add few polysaccharide, be placed in mixer and stir, fully mix, pulverize finally by superfine communication technique, make superfine powder.
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| CN104922648A (en) * | 2015-07-16 | 2015-09-23 | 山东中牧兽药有限公司 | Traditional Chinese medicine composite for treating chicken diarrhea and preparation method thereof |
| CN106562062A (en) * | 2016-11-09 | 2017-04-19 | 广西兴业县金泉牧业养殖专业合作社 | Feed for ecological pig raising |
| CN106822890A (en) * | 2017-01-19 | 2017-06-13 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of pharmaceutical composition for preventing and treating diarrhea of weaned piglets and its preparation method and application |
| CN109758546A (en) * | 2019-03-29 | 2019-05-17 | 刘坚 | A kind of herbal composite that treating chitling gastric disorder and its processing and application |
| CN110025704A (en) * | 2019-05-28 | 2019-07-19 | 皖西学院 | Chinese herbal formula and preparation method thereof for treating grice diarrhoea |
| CN112494577A (en) * | 2020-12-23 | 2021-03-16 | 河南牧业经济学院 | Traditional Chinese medicine microecological preparation for treating piglet diarrhea and preparation method thereof |
| CN113599430A (en) * | 2021-09-07 | 2021-11-05 | 四川港投滨水农业研究院有限公司 | Livestock diarrhea treatment prescription and preparation method thereof |
| CN114343056A (en) * | 2022-01-04 | 2022-04-15 | 江西省农业科学院畜牧兽医研究所 | Omics type Chinese herbal medicine functional substitution antibody composition for weaned piglets and preparation method and application thereof |
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| CN104922648A (en) * | 2015-07-16 | 2015-09-23 | 山东中牧兽药有限公司 | Traditional Chinese medicine composite for treating chicken diarrhea and preparation method thereof |
| CN106562062A (en) * | 2016-11-09 | 2017-04-19 | 广西兴业县金泉牧业养殖专业合作社 | Feed for ecological pig raising |
| CN106822890A (en) * | 2017-01-19 | 2017-06-13 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of pharmaceutical composition for preventing and treating diarrhea of weaned piglets and its preparation method and application |
| CN109758546A (en) * | 2019-03-29 | 2019-05-17 | 刘坚 | A kind of herbal composite that treating chitling gastric disorder and its processing and application |
| CN110025704A (en) * | 2019-05-28 | 2019-07-19 | 皖西学院 | Chinese herbal formula and preparation method thereof for treating grice diarrhoea |
| CN110025704B (en) * | 2019-05-28 | 2021-11-12 | 皖西学院 | Compound Chinese herbal medicine preparation for treating piglet diarrhea and preparation method thereof |
| CN112494577A (en) * | 2020-12-23 | 2021-03-16 | 河南牧业经济学院 | Traditional Chinese medicine microecological preparation for treating piglet diarrhea and preparation method thereof |
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Application publication date: 20150401 |