CN113599430A - Livestock diarrhea treatment prescription and preparation method thereof - Google Patents

Abstract

The invention relates to a livestock diarrhea treatment prescription and a preparation method thereof, wherein the prescription comprises the following components in parts by weight: 10-15 parts of gelsemium elegans, 9-13 parts of codonopsis pilosula, 7-10 parts of pomegranate rind, 10-15 parts of astragalus membranaceus, 3-5 parts of coptis chinensis, 6-10 parts of divaricate saposhnikovia root, 5-8 parts of radix bupleuri, 7-11 parts of dried orange peel, 3-6 parts of cassia bark, 3-6 parts of Chinese angelica, 7-10 parts of white heads and 5-8 parts of liquorice. The prescription can not only radically cure diarrhea, but also can not damage the spleen and stomach functions of piglets.

Description

Livestock diarrhea treatment prescription and preparation method thereof

Technical Field

The invention relates to the field of livestock disease treatment medicines, in particular to a livestock diarrhea treatment prescription and a preparation method thereof.

Background

Livestock in the young period, such as piglets, have low self-resistance due to the fact that a stable micro-ecosystem is not established in the intestinal tract, are sensitive to external stimuli, and are susceptible to the invasion of various pathogenic microorganisms and the influence of various stress factors to cause diarrhea. Causes of diarrhea in suckling piglets include: (1) bacterial diarrhea, mainly diarrhea caused by Escherichia coli, Clostridium welchii enteritis, swine dysentery bacillus, etc.; (2) viral diarrhea, mainly diarrhea caused by transmissible gastroenteritis, epidemic diarrhea, coronavirus, porcine pseudocanine virus, etc.; (3) parasitic diarrhea, mainly diarrhea caused by roundworm, coccidia, whipworm, balantis coli, etc.; (4) non-infectious factors, such as temperature, hypoglycemia, daily ration antigen allergic diarrhea, nonpathogenic white dysentery, etc.

At present, the diarrhea of the captive piglets is mainly treated by antibiotics, so that the spleen and stomach functions of the piglets are destroyed, and the diarrhea is difficult to be cured radically.

Disclosure of Invention

In view of the above, the present invention provides a livestock diarrhea treatment prescription and a preparation method thereof, which at least partially solve the problems in the prior art.

The invention provides a livestock diarrhea treatment prescription which comprises the following components in parts by weight:

10-15 parts of gelsemium elegans, 9-13 parts of codonopsis pilosula, 7-10 parts of pomegranate rind, 10-15 parts of astragalus membranaceus, 3-5 parts of coptis chinensis, 6-10 parts of divaricate saposhnikovia root, 5-8 parts of radix bupleuri, 7-11 parts of dried orange peel, 3-6 parts of cassia bark, 3-6 parts of Chinese angelica, 7-10 parts of white heads and 5-8 parts of liquorice.

Further, the formulation is used for treating diarrhea in piglets.

Further, when the prescription is used for treating diarrhea of piglets, the prescription comprises the following components in parts by weight: 13.6 parts of gelsemium elegans, 11.3 parts of codonopsis pilosula, 9.0 parts of pomegranate rind, 13.6 parts of astragalus membranaceus, 4.5 parts of coptis chinensis, 8.1 parts of divaricate saposhnikovia root, 6.8 parts of radix bupleuri, 9.0 parts of dried orange peel, 4.5 parts of cassia bark, 4.5 parts of Chinese angelica, 8.1 parts of white heads and 6.8 parts of liquorice.

Further, the feed additive also comprises 1-3 parts of active factors by weight.

Further, the active factor is charred hawthorn or wrinkled gianthyssop herb.

Further comprises 1-3 parts of semen plantaginis by weight.

Further, the prescription is one of powder, decoction, powder, tablets, electuary, bagged steeping drug, oral liquid or capsules.

The invention also provides a preparation method of the livestock diarrhea treatment prescription, which comprises the steps of respectively cleaning and drying 10-15 parts of gelsemium elegans, 9-13 parts of codonopsis pilosula, 7-10 parts of pomegranate rind, 10-15 parts of astragalus mongholicus, 3-5 parts of coptis chinensis, 6-10 parts of divaricate saposhnikovia root, 5-8 parts of radix bupleuri, 7-11 parts of pericarpium citri reticulatae, 3-6 parts of cassia bark, 3-6 parts of Chinese angelica, 7-10 parts of rhizoma coptidis and 5-8 parts of liquorice in parts by weight;

placing the dried components in a sterile bin, and grinding the components in a traditional Chinese medicine grinder under sterile and dustless conditions;

sieving and breaking the wall of the ground components through a l20 mesh sieve to obtain powdery components;

the powdered components are blended and mixed evenly to obtain the prescription.

The technical scheme provided by the invention has the following beneficial effects:

1. the traditional Chinese medicine preparation is developed aiming at the transformation of complications starting from the pathogenesis of diarrhea of captive piglets, and comprehensively regulates the digestive system of the piglets by using a plurality of medicines, and has the effects of removing food retention and helping digestion, tonifying qi and strengthening the spleen, warming middle-jiao and dispelling cold, promoting diuresis and excreting dampness, and inducing astringency to stop diarrhea; the traditional treatment limitation is broken through, and the medicine can protect intestinal probiotics to the maximum extent and integrally adjust the gastrointestinal function while treating diarrhea of captive piglets;

2. the traditional antidiarrheal medicine has the effects of strengthening the gastrointestinal function, inhibiting the excessive peristalsis of the intestinal tract, clearing toxins in the intestinal tract, recovering the intestinal tract function, strengthening the spleen and arresting discharge, and breaking the traditional antidiarrheal effect of stopping diarrhea, and can regulate the imbalance of viscera and spleen deficiency and damp-heat diarrhea caused by imbalance of yin and yang;

3. the traditional Chinese medicine composition has the advantages that the immunity of the organism is improved, the water metabolism in the body is comprehensively improved, the diarrhea and the pain are relieved, the traditional tactics is broken through by comprehensive treatment of a plurality of medicines, the comprehensive attack is realized, the digestion function is improved, the water metabolism is regulated and controlled, the balance of yin and yang is corrected, and the spasm of smooth muscle of the stomach and intestine is relieved, so that the diarrhea and the pain are relieved;

4. clearing away turbid materials, promoting the absorption of water in the intestinal tract, rapidly removing toxic substances in the intestinal tract, reducing the absorption of toxins and relieving the intestinal pressure;

5. the external medicine has small side effect, can effectively remove harmful substances in intestinal tracts while being absorbed locally and quickly, fundamentally reverses the pathogenesis of diarrhea of captive piglets, and finally achieves the aim of rehabilitation;

6. radical cure is carried out completely without long-term administration, after active molecules in the medicine enter piglets, disordered digestive systems are activated and regulated to be normal, the medicine is taken for 2-3 courses of treatment, the digestive function of the body is recovered, diarrhea is recovered to be normal, and the medicine is consolidated and separated without rebound and is in a healthy state.

Detailed Description

The following describes embodiments of the present invention in detail.

It should be noted that, in the case of no conflict, the features in the following embodiments and examples may be combined with each other; moreover, all other embodiments that can be derived by one of ordinary skill in the art from the embodiments disclosed herein without making any creative effort fall within the scope of the present disclosure.

It is noted that various aspects of the embodiments are described below within the scope of the appended claims. It should be apparent that the aspects described herein may be embodied in a wide variety of forms and that any specific structure and/or function described herein is merely illustrative. Based on the disclosure, one skilled in the art should appreciate that one aspect described herein may be implemented independently of any other aspects and that two or more of these aspects may be combined in various ways. For example, an apparatus may be implemented and/or a method practiced using any number of the aspects set forth herein. Additionally, such an apparatus may be implemented and/or such a method may be practiced using other structure and/or functionality in addition to one or more of the aspects set forth herein.

In one embodiment, the invention provides a livestock diarrhea treatment prescription, which comprises the following components in parts by weight: 10-15 parts of gelsemium elegans, 9-13 parts of codonopsis pilosula, 7-10 parts of pomegranate rind, 10-15 parts of astragalus membranaceus, 3-5 parts of coptis chinensis, 6-10 parts of divaricate saposhnikovia root, 5-8 parts of radix bupleuri, 7-11 parts of dried orange peel, 3-6 parts of cassia bark, 3-6 parts of Chinese angelica, 7-10 parts of white heads and 5-8 parts of liquorice.

In particular, the formulations are useful for treating diarrhea in piglets. According to the etiology and pathology of diarrhea of captive piglets, the medicine has the main effects of tonifying qi and strengthening spleen, relieving diarrhea with astringents, comprehensively conditioning digestive organs, distinguishing deficiency from excess, eliminating stagnation and promoting digestion, clearing heat and promoting diuresis, warming middle-jiao and dispelling cold, strengthening spleen and tonifying qi, promoting diuresis and excreting wet method, and relieving diarrhea with astringents.

In order to improve the curative effect, when the formula is used for treating piglet diarrhea, the formula comprises the following components in parts by weight: 13.6 parts of gelsemium elegans, 11.3 parts of codonopsis pilosula, 9.0 parts of pomegranate rind, 13.6 parts of astragalus membranaceus, 4.5 parts of coptis chinensis, 8.1 parts of divaricate saposhnikovia root, 6.8 parts of radix bupleuri, 9.0 parts of dried orange peel, 4.5 parts of cassia bark, 4.5 parts of Chinese angelica, 8.1 parts of white heads and 6.8 parts of liquorice.

Furthermore, the prescription also comprises 1-3 parts of active factors by weight, the active factors are charred hawthorn or wrinkled gianthyssop herb, and the charred hawthorn, the wrinkled gianthyssop herb and other active factors in the medicine can quickly digest food, clear heat and dry dampness, and resist bacteria and diminish inflammation. The prescription also comprises 1-3 parts of semen plantaginis by weight, wherein the semen plantaginis in the medicine has the functions of clearing heat and promoting diuresis, and the poria cocos enhances the immunity function. The amomum fruit and officinal magnolia bark in the medicine can warm the middle-jiao to dispel cold, promote qi circulation and relieve pain. The effective components can repair and regenerate damaged cells and relieve gastrointestinal pressure. The radix Angelicae sinensis and semen Ziziphi Spinosae in the formula have effects of replenishing blood and tranquilizing mind, and the effective components can purify blood, increase erythrocyte, heme and bilirubin, and rapidly relieve dizziness, insomnia and cardiopalmus. The yam and the atractylodes in the prescription can tonify spleen and stop diarrhea. The effective components can promote water absorption of intestinal tract, and restore self-regulating function of intestinal tract. The medicine such as the aged pomegranate and the red halloysite in the prescription has good inhibition effect on the rapid intestinal peristalsis.

Specifically, the prescription is one of powder, decoction, powder, tablet, granule, bagged steeping drug, oral liquid or capsule.

In addition to the above formula, the invention also provides a preparation method of the above formula for treating diarrhea of livestock, which comprises the steps of respectively cleaning and drying 10-15 parts of gelsemium elegans, 9-13 parts of codonopsis pilosula, 7-10 parts of pomegranate rind, 10-15 parts of astragalus membranaceus, 3-5 parts of coptis chinensis, 6-10 parts of divaricate saposhnikovia root, 5-8 parts of radix bupleuri, 7-11 parts of pericarpium citri reticulatae, 3-6 parts of cassia bark, 3-6 parts of Chinese angelica, 7-10 parts of white hair and 5-8 parts of liquorice in parts by weight; placing the dried components in a sterile bin, and grinding the components in a traditional Chinese medicine grinder under sterile and dustless conditions; sieving and breaking the wall of the ground components through a l20 mesh sieve to obtain powdery components; the powdered components are blended and mixed evenly to obtain the prescription.

The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.

Example 1

Respectively cleaning and drying 13.6 parts of gelsemium elegans, 11.3 parts of codonopsis pilosula, 9.0 parts of pomegranate rind, 13.6 parts of astragalus membranaceus, 4.5 parts of coptis chinensis, 8.1 parts of divaricate saposhnikovia root, 6.8 parts of radix bupleuri, 9.0 parts of pericarpium citri reticulatae, 4.5 parts of cassia bark, 4.5 parts of Chinese angelica, 8.1 parts of rhizoma typhonii and 6.8 parts of liquorice in parts by weight;

placing the dried components in a sterile bin, and grinding the components in a traditional Chinese medicine grinder under sterile and dustless conditions;

sieving and breaking the wall of the ground components through a l20 mesh sieve to obtain powdery components;

the powdered components are blended and mixed evenly to obtain the prescription.

Example 2

Respectively cleaning and drying 12 parts of gelsemium elegans, 10.5 parts of codonopsis pilosula, 8.0 parts of pomegranate bark, 11.5 parts of astragalus membranaceus, 3.5 parts of coptis chinensis, 8.1 parts of divaricate saposhnikovia root, 6.8 parts of radix bupleuri, 10.0 parts of dried orange peel, 4.5 parts of cassia bark, 4.5 parts of Chinese angelica, 8.5 parts of white heads and 6 parts of liquorice in parts by weight;

placing the dried components in a sterile bin, and grinding the components in a traditional Chinese medicine grinder under sterile and dustless conditions;

sieving and breaking the wall of the ground components through a l20 mesh sieve to obtain powdery components;

the powdered components are blended and mixed evenly to obtain the prescription.

Example 3

Respectively cleaning 14 parts of gelsemium elegans, 11 parts of codonopsis pilosula, 8 parts of pomegranate rind, 12 parts of astragalus membranaceus, 5 parts of coptis chinensis, 9 parts of radix sileris, 7 parts of radix bupleuri, 8 parts of pericarpium citri reticulatae, 5 parts of cinnamon, 4 parts of angelica sinensis, 9 parts of rhizoma anemones vitifolia and 7 parts of liquorice and drying;

placing the dried components in a sterile bin, and grinding the components in a traditional Chinese medicine grinder under sterile and dustless conditions;

sieving and breaking the wall of the ground components through a l20 mesh sieve to obtain powdery components;

the powdered components are blended and mixed evenly to obtain the prescription.

Example 4

Respectively cleaning and drying 13.6 parts of gelsemium elegans, 11.3 parts of codonopsis pilosula, 9.0 parts of pomegranate rind, 13.6 parts of astragalus membranaceus, 4.5 parts of coptis chinensis, 8.1 parts of divaricate saposhnikovia root, 6.8 parts of radix bupleuri, 9.0 parts of pericarpium citri reticulatae, 4.5 parts of cassia bark, 4.5 parts of Chinese angelica, 8.1 parts of rhizoma typhonii and 6.8 parts of liquorice in parts by weight;

placing the dried components in a sterile bin, and grinding the components in a traditional Chinese medicine grinder under sterile and dustless conditions;

sieving and breaking the wall of the ground components through a l20 mesh sieve to obtain powdery components;

the powdered components are blended and mixed evenly to obtain the prescription.

Example 5

Respectively cleaning 14 parts by weight of gelsemium elegans, 12.3 parts by weight of codonopsis pilosula, 8.3 parts by weight of pomegranate rind, 12.6 parts by weight of astragalus membranaceus, 3.5 parts by weight of coptis chinensis, 8.8 parts by weight of divaricate saposhnikovia root, 7 parts by weight of radix bupleuri, 9.5 parts by weight of dried orange peel, 5.5 parts by weight of cassia bark, 5 parts by weight of Chinese angelica, 8.5 parts by weight of white heads and 5.8 parts by weight of liquorice, and drying;

placing the dried components in a sterile bin, and grinding the components in a traditional Chinese medicine grinder under sterile and dustless conditions;

sieving and breaking the wall of the ground components through a l20 mesh sieve to obtain powdery components;

the powdered components are blended and mixed evenly to obtain the prescription.

Example 6

Respectively cleaning and drying 13.1 parts of gelsemium elegans, 12.3 parts of codonopsis pilosula, 9.3 parts of pomegranate rind, 13.5 parts of astragalus membranaceus, 4.8 parts of coptis chinensis, 7.1 parts of divaricate saposhnikovia root, 6.2 parts of radix bupleuri, 9.5 parts of dried orange peel, 4.8 parts of cassia bark, 4.8 parts of Chinese angelica, 8.5 parts of white heads and 7.8 parts of liquorice in parts by weight;

placing the dried components in a sterile bin, and grinding the components in a traditional Chinese medicine grinder under sterile and dustless conditions;

sieving and breaking the wall of the ground components through a l20 mesh sieve to obtain powdery components; the powdered components are blended and mixed evenly to obtain the prescription.

Example 7

Respectively cleaning and drying 10.5 parts of gelsemium elegans, 10 parts of codonopsis pilosula, 9.5 parts of pomegranate bark, 10.8 parts of astragalus membranaceus, 4.6 parts of coptis chinensis, 8.8 parts of divaricate saposhnikovia root, 5.5 parts of radix bupleuri, 8.0 parts of dried orange peel, 4.5 parts of cassia bark, 4.5 parts of Chinese angelica, 8.1 parts of white heads and 6.8 parts of liquorice in parts by weight;

placing the dried components in a sterile bin, and grinding the components in a traditional Chinese medicine grinder under sterile and dustless conditions;

sieving and breaking the wall of the ground components through a l20 mesh sieve to obtain powdery components; the powdered components are blended and mixed evenly to obtain the prescription.

Example 8

Respectively cleaning and drying 12.6 parts of clinopodium polycephalum, 12.3 parts of codonopsis pilosula, 10.0 parts of pomegranate rind, 12.6 parts of astragalus membranaceus, 4.5 parts of coptis chinensis, 8.1 parts of divaricate saposhnikovia root, 6.8 parts of radix bupleuri, 9.0 parts of pericarpium citri reticulatae, 4.5 parts of cassia bark, 4.5 parts of Chinese angelica, 8.1 parts of rhizoma typhonii and 6.8 parts of liquorice in parts by weight;

placing the dried components in a sterile bin, and grinding the components in a traditional Chinese medicine grinder under sterile and dustless conditions;

sieving and breaking the wall of the ground components through a l20 mesh sieve to obtain powdery components;

the powdered components are blended and mixed evenly to obtain the prescription.

Comparative example 1

Continuously taking apramycin orally for 7 days at a dose of 15mg/kg body weight every day, and simultaneously taking glucose normal saline and multivitamins orally to supplement the solution; the formula of the glucose normal saline comprises the following components: to 1000ml of water were added 20 g of glucose, 3.5 g of sodium chloride, 1.5 g of potassium chloride and 2.5 g of sodium bicarbonate.

Comparative example 2

Orally taken, the intramuscular injection of the florfenicol thiamphenicol is carried out for 1 time per day with the dose of 20-30 mg per kg of body weight for 3-5 days continuously, and meanwhile, the intramuscular injection of the florfenicol premix with the concentration of 2 percent is carried out for 7 days continuously after 1-2 g of the florfenicol premix is added per kg of feed.

The diarrhea treatment formulas provided in embodiments 1 to 8 of the present invention were systematically evaluated for their effects through clinical trials, in which the number of affected piglets in each treatment sample was 20, and the evaluation dimensions included a cure rate, a cure period, a recurrence rate within half a year, a recurrence rate within one year, and a recovery period, wherein the cure period refers to a time required for disappearance of diarrhea symptoms, and the recovery period refers to a time required for complete recovery of gastrointestinal functions after disappearance of diarrhea symptoms, and the diarrhea treatment methods provided in comparative examples 1 to 2 were used as controls, and the results are shown in table 1:

table 1 evaluation test results

According to the embodiments, the technical scheme provided by the invention has the following beneficial effects:

1. the traditional Chinese medicine preparation is developed aiming at the transformation of complications starting from the pathogenesis of diarrhea of captive piglets, and comprehensively regulates the digestive system of the piglets by using a plurality of medicines, and has the effects of removing food retention and helping digestion, tonifying qi and strengthening the spleen, warming middle-jiao and dispelling cold, promoting diuresis and excreting dampness, and inducing astringency to stop diarrhea; the traditional treatment limitation is broken through, and the medicine can protect intestinal probiotics to the maximum extent and integrally adjust the gastrointestinal function while treating diarrhea of captive piglets;

2. the traditional antidiarrheal medicine has the effects of strengthening the gastrointestinal function, inhibiting the excessive peristalsis of the intestinal tract, clearing toxins in the intestinal tract, recovering the intestinal tract function, strengthening the spleen and arresting discharge, and breaking the traditional antidiarrheal effect of stopping diarrhea, and can regulate the imbalance of viscera and spleen deficiency and damp-heat diarrhea caused by imbalance of yin and yang;

3. the traditional Chinese medicine composition has the advantages that the immunity of the organism is improved, the water metabolism in the body is comprehensively improved, the diarrhea and the pain are relieved, the traditional tactics is broken through by comprehensive treatment of a plurality of medicines, the comprehensive attack is realized, the digestion function is improved, the water metabolism is regulated and controlled, the balance of yin and yang is corrected, and the spasm of smooth muscle of the stomach and intestine is relieved, so that the diarrhea and the pain are relieved;

4. clearing away turbid materials, promoting the absorption of water in the intestinal tract, rapidly removing toxic substances in the intestinal tract, reducing the absorption of toxins and relieving the intestinal pressure;

5. the external medicine has small side effect, can effectively remove harmful substances in intestinal tracts while being absorbed locally and quickly, fundamentally reverses the pathogenesis of diarrhea of captive piglets, and finally achieves the aim of rehabilitation;

6. radical cure is carried out completely without long-term administration, after active molecules in the medicine enter piglets, disordered digestive systems are activated and regulated to be normal, the medicine is taken for 2-3 courses of treatment, the digestive function of the body is recovered, diarrhea is recovered to be normal, and the medicine is consolidated and separated without rebound and is in a healthy state.

The above description is only for the specific embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (8)

1. A diarrhea treatment prescription for livestock, which is characterized in that: the paint comprises the following components in parts by weight:

10-15 parts of gelsemium elegans, 9-13 parts of codonopsis pilosula, 7-10 parts of pomegranate rind, 10-15 parts of astragalus membranaceus, 3-5 parts of coptis chinensis, 6-10 parts of divaricate saposhnikovia root, 5-8 parts of radix bupleuri, 7-11 parts of dried orange peel, 3-6 parts of cassia bark, 3-6 parts of Chinese angelica, 7-10 parts of white heads and 5-8 parts of liquorice.

2. The livestock diarrhea treatment prescription according to claim 1, characterized in that: the formulation is used for treating diarrhea in piglets.

3. The livestock diarrhea treatment prescription according to claim 2, characterized in that: when the prescription is used for treating piglet diarrhea, the prescription comprises the following components in parts by weight:

13.6 parts of gelsemium elegans, 11.3 parts of codonopsis pilosula, 9.0 parts of pomegranate rind, 13.6 parts of astragalus membranaceus, 4.5 parts of coptis chinensis, 8.1 parts of divaricate saposhnikovia root, 6.8 parts of radix bupleuri, 9.0 parts of dried orange peel, 4.5 parts of cassia bark, 4.5 parts of Chinese angelica, 8.1 parts of white heads and 6.8 parts of liquorice.

4. The livestock diarrhea treatment prescription according to claim 3, characterized in that: also comprises 1-3 parts of active factors by weight.

5. The livestock diarrhea treatment formulation according to claim 4, wherein said active factor is Crataegus oxyacantha or Pogostemon cablin.

6. The livestock diarrhea treatment prescription according to claim 5, characterized in that: also comprises 1 to 3 parts of plantain seeds by weight.

7. The livestock diarrhea treatment prescription according to any one of claims 1 to 6, characterized in that: the formulation is one of powder, decoction, powder, tablet, granule, bagged steeping drug, oral liquid or capsule.

8. A preparation method of a livestock diarrhea treatment prescription according to any one of claims 1-7, characterized in that, by weight, 10-15 parts of gelsemium elegans, 9-13 parts of codonopsis pilosula, 7-10 parts of pomegranate rind, 10-15 parts of astragalus, 3-5 parts of coptis, 6-10 parts of divaricate saposhnikovia root, 5-8 parts of radix bupleuri, 7-11 parts of dried orange peel, 3-6 parts of cassia bark, 3-6 parts of angelica, 7-10 parts of white head and 5-8 parts of liquorice are respectively cleaned and dried;

placing the dried components in a sterile bin, and grinding the components in a traditional Chinese medicine grinder under sterile and dustless conditions;

sieving and breaking the wall of the ground components through a l20 mesh sieve to obtain powdery components;

the powdered components are blended and mixed evenly to obtain the prescription.