CN101028451A - Chinese medicine for treating tic douloureux - Google Patents
Chinese medicine for treating tic douloureux Download PDFInfo
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- CN101028451A CN101028451A CNA2007100654833A CN200710065483A CN101028451A CN 101028451 A CN101028451 A CN 101028451A CN A2007100654833 A CNA2007100654833 A CN A2007100654833A CN 200710065483 A CN200710065483 A CN 200710065483A CN 101028451 A CN101028451 A CN 101028451A
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Abstract
A Chinese medicine for treating trigeminal neuralgia is prepared from 10 Chinese-medicinal materials including Chuan-xiong rhizome, asarum herb, gastrodia tuber, earthworm, etc.
Description
Technical field
The present invention relates to the prosopalgic Chinese patent medicine of a kind of treatment, is that a kind of trigeminal neuralgia for the treatment of is the Chinese patent medicine of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.
Background technology
Trigeminal neuralgia is meant the paroxysmal severe pain of outbreak repeatedly in the facial nervi trigeminus areal area, claim trismus dolorificus again.Primary disease 70%～80% case pilosity was born in more than 40 years old, and the women is slightly more than the male, is about 3: 2～2: 1; Majority is one-sided property, only has about 5% to be bilateral.Trigeminal neuralgia belongs to categories such as Chinese medicine " prosopodynia ", " migraine ", " wind syndrome of head ", " jaw wind ".
Chinese medicine is thought the sick position of primary disease in women's head-ornaments portion, how is subjected to due to the disease by women's head-ornaments portion three YANG meridians network.Its etiology and pathogenesis is comparatively complicated, in brief has diseases caused by exogenous pathogenic factor and internal injury not, simultaneously closely related with ailment said due to cold or exposure again.Generally diseases caused by exogenous pathogenic factor are caused a disease, and on high mountain peak, only wind can reach, and ailment said due to cold or exposure rises to be sent out, and easily violates women's head-ornaments, and ailment said due to cold or exposure is every and cold, fire, expectorant are held concurrently the clamping heresy, so that wind and cold stagnates, or wind-fire burns, or wind-phlegm is stopped up resistance three YANG meridians network and sent out and be pain.Internal injury is caused a disease, and is every hot and suffocating with liver and gall, inflammation on the stomach excessive heat, hyperactivity of YANG due to deficiency of YIN and wind-transformation etc. are closely related, and then wind-fire attacks punch face, on disturb key clearly, and cause pain; Or by the women's head-ornaments stagnation of QI-blood, block the three YANG meridians network, stagnation of QI and blood may bring about pain, also for internal injury pathogenic because of.Exopathogen causes a disease, and does not with the passing of time heal, and outbreak often can follow in going into the heat-transformation impairment of YIN repeatedly; And the pathogenic also many being invaded by exogenous pathogen of internal injury aggravate disease, so inside and outside combined pathogens is the another clinical characters that primary disease takes place for suffering from.Trigeminal neuralgia is the severe pain of showing effect repeatedly in the nervi trigeminus areal area, owing to everyday actions such as speaking, take food, drink water, wash one's face, brush teeth all may be brought out pain, thereby has seriously influenced patient's orthobiosis.
The Therapeutic Method of primary disease is numerous, see that with acupuncture, outer Zhiduo County such as apply ointment or plaster Drug therapy is based on antuepileptic especially, and the Drug therapy side effect is big; The operation and closed treating be with the retardance, the compressing and the damage nervi trigeminus be main means, some can leave over complication.Because primary disease is main performance with pain, the differential diagnosis in tcm treatment is divided into: wind and cold coagulates network, wind heat is hindered disease types such as network, wind-phlegm heap soil or fertilizer over and around the roots network, flaming up of stomach-fire, disturbing upward of liver-fire, stagnation of blood stasis and obtained excellent curative, and short treating period, does not recur.
Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide the prosopalgic Chinese patent medicine of a kind of treatment.Have determined curative effect, safe ready, little, the cheap characteristics of side effect.
The present invention is made by the following weight proportion raw material:
0.1～0.5 part of 1.5～6 parts of Herba Asari of 0.1～2 part of Rhizoma Chuanxiong of Arisaema Cum Bile
0.1～2 part of 1.5～6 parts of Pheretima of 0.1～1 part of Rhizoma Gastrodiae of Rhizoma Typhonii
0.1～2 part of 1.5～6 parts of Radix Angelicae Dahuricae of 1～4 part of Radix Angelicae Sinensis of Bombyx Batryticatus
0.1～2 part of Rhizoma Corydalis
The weight proportion of each raw material of optimization formula of the present invention is:
0.2～0.4 part of 2.5～3.5 parts of Herba Asari of 0.5～1.5 part of Rhizoma Chuanxiong of Arisaema Cum Bile
0.5～1.5 part of 2.5～3.5 parts of Pheretima of 0.3～0.7 part of Rhizoma Gastrodiae of Rhizoma Typhonii
0.5～1.5 part of 2.5～3.5 parts of Radix Angelicae Dahuricae of 1.5～2.5 parts of Radix Angelicae Sinensis of Bombyx Batryticatus
0.5～1.5 part of Rhizoma Corydalis
The weight proportion of each raw material of optimum formula of the present invention is:
0.3 part of 3 parts of Herba Asari of 1 part of Rhizoma Chuanxiong of Arisaema Cum Bile
1 part of 3 parts of Pheretima of 0.5 part of Rhizoma Gastrodiae of Rhizoma Typhonii
1 part of 3 parts of Radix Angelicae Dahuricae of 2 parts of Radix Angelicae Sinensis of Bombyx Batryticatus
1 part of Rhizoma Corydalis
Drug action mechanism among the present invention is as follows:
Arisaema Cum Bile nature and flavor hardship, little suffering, cold.Return liver, gallbladder, lung meridian.Has clearing away fire and eliminating phlegm, the effect of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc.Cure mainly apoplexy, infantile convulsion, epilepsy, headache, dizzy, breathe heavily and cough etc.(the 2380th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Rhizoma Chuanxiong nature and flavor suffering, perfume (or spice).Return liver, gallbladder, pericardium channel.Has blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.Can treat menoxenia, amenorrhea dysmenorrhea, difficult labour, lump in the abdomen stomachache, the twinge of the breast side of body, arthralgia due to cold clonic spasm of the muscle, tumbling and swelling, headache due to pathogenic wind-heat, rheumatic arthralgia, skin infection swells and ache, placenta retention, cerebral ischemia, coronary heart disease, angina pectoris, atherosclerosis, hypertension, leukopenia due to the radiotherapy, chemotherapy, juvenile myopia, vitamin e deficiency, flu is dizzy, external plug nose treating malaria disease etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 171st page).
Herba Asari nature and flavor suffering, temperature, mild toxicity.Return lung, kidney, heart channel.Have cold expelling and dispel the wind, pain relieving, warming the lung to resolve fluid-retention, sensible effect.Cure mainly wind and cold table disease, headache, toothache, rheumatic arthralgia, phlegm retention cough with asthma, nasal obstruction, nasal sinusitis, aphtha etc.(the 2087th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Rhizoma Typhonii nature and flavor suffering, temperature; Poisonous.Return stomach, Liver Channel.Have the expectorant of dispeling the wind, arresting convulsion is jerked, detoxicating and resolving stagnation of pathogens analgesic effect.Wind-phlegm is stopped up in can treating, facial hemiparalysis, and language is puckery stuttering, syncope due to accumulation of phlegm headache, migraine and general headache, sore throat pharyngalgia, tetanus; External treatment scrofula sucutaneous nodule, venom etc. (the 80th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The Rhizoma Gastrodiae nature and flavor are sweet, hot, and are flat.Return Liver Channel.Has relieving spasm by subduing liver-wind, suppressing the hyperactive liver sun, the effect of dispelling wind and removing obstruction in the collateral.Cure mainly anxious chronic infantile convulsion, the tic contracture, tetanus, dizzy, headache, hemiplegia, limb fiber crops, rheumatic arthralgia etc.(the 432nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Pheretima nature and flavor are salty, cold.Go into liver, spleen, lung, urinary bladder channel.Have heat clearing away, suppressing the hyperactive liver, Zhichuan, collateral dredging diuretic effect.Cure mainly high fanatical dry, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pant, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection, hyperpyrexia, bronchial asthma, hypertension, psychosis, ulcer of the lower limb, eczema, erysipelas, burn and scald, fracture etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 522nd page).
Bombyx Batryticatus nature and flavor suffering, salty, flat.Return liver, lung, stomach warp.Have expelling wind and relieving convulsion, dissipating phlegm and resolving masses, the effect of resolving toxin and disinhibiting the throat.Cure mainly infantile convulsion and twitch apoplexy facial hemiparalysis, migraine and general headache, laryngopharynx swelling and pain, scrofula, mumps, rubella, sore etc.(the 1021st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Radix Angelicae Sinensis nature and flavor are sweet, hot, warm.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.Can be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea stimulates the menstrual flow, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, traumatic injury, ulcer sores etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 553rd page).
Radix Angelicae Dahuricae nature and flavor suffering, temperature.Return stomach, large intestine, lung meridian.Has diffusing wind dehumidifying, understand things pain-stopping, the effect of detumescence and apocenosis.Can treat headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache etc.(the 79th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Rhizoma Corydalis nature and flavor suffering, hardship, wet.Return liver, spleen channel.Have and invigorate blood circulation, promoting the circulation of QI, analgesic effect.Can treat the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, treating swelling and pain by traumatic injury etc. (Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 680th page).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Rhizoma Chuanxiong, Herba Asari, Rhizoma Gastrodiae and Pheretima; With Arisaema Cum Bile, Radix Angelicae Sinensis, Rhizoma Typhonii and Bombyx Batryticatus is ministerial drug; With the Radix Angelicae Dahuricae and Rhizoma Corydalis is adjuvant.All medicines are harmonious, and common tool is invigorated blood circulation sensible, the effect of wind-expelling pain-stopping.Treatment trigeminal neuralgia determined curative effect, toxic and side effects is little, taking convenience.
Chinese patent medicine of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese patent medicine of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.
Preparation of the present invention, peroral dosage form preferably, as: tablet capsule agent, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese patent medicine is capsule, tablet, granule.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment trigeminal neuralgia of the Chinese medicine of respectively distinguishing the flavor of, and does not have chemical sweeting agent, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.
3, the present invention can treat trigeminal neuralgia effectively, has improved patient's quality of life greatly, and higher healing rehabilitation efficacy is arranged.
Further specify medicine of the present invention to treating prosopalgic therapeutic effect below by the clinical practice example.Trigeminal neuralgia (wind syndrome of head) curative effect determinate standard (the 183rd page of chief editor's " traditional Chinese medical science disease diagnosis and treatment standard and prescription are selected for use " People's Health Publisher's calendar year 2001 version such as Dai Shen).
1, cure: headache disappears, and every lab testing is normal.
2, take a turn for the better: headache alleviates, and duration of seizure shortens or cycle stretch-out, and lab testing has improvement.
3, do not heal: headache symptom and blood pressure no change.
For showing medicine of the present invention, as follows through clinical test results to the trigeminal neuralgia therapeutic effect; Treatment trigeminal neuralgia patient 68 examples are taken embodiment 1 capsule, each 2-10 grain, and every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.Cure 32 examples and account for 47%, 33 examples that take a turn for the better account for 48.5%, and more 3 examples do not account for 4.5%, and total effective rate reaches more than 95%.After three course of therapy, symptoms such as patient's pain all have obvious change or recovery from illness.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
Embodiment 1 capsule takes by weighing raw material by following weight:
0.3 part of 3 parts of Herba Asari of 1 part of Rhizoma Chuanxiong of Arisaema Cum Bile
1 part of 3 parts of Pheretima of 0.5 part of Rhizoma Gastrodiae of Rhizoma Typhonii
1 part of 3 parts of Radix Angelicae Dahuricae of 2 parts of Radix Angelicae Sinensis of Bombyx Batryticatus
1 part of Rhizoma Corydalis
Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, and 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.
Embodiment 2 tablets take by weighing raw material by following weight:
0.3 part of 3 parts of Herba Asari of 1 part of Rhizoma Chuanxiong of Arisaema Cum Bile
1 part of 3 parts of Pheretima of 0.5 part of Rhizoma Gastrodiae of Rhizoma Typhonii
1 part of 3 parts of Radix Angelicae Dahuricae of 2 parts of Radix Angelicae Sinensis of Bombyx Batryticatus
1 part of Rhizoma Corydalis
Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.
Embodiment 3 granules take by weighing raw material by following weight:
0.3 part of 3 parts of Herba Asari of 1 part of Rhizoma Chuanxiong of Arisaema Cum Bile
1 part of 3 parts of Pheretima of 0.5 part of Rhizoma Gastrodiae of Rhizoma Typhonii
1 part of 3 parts of Radix Angelicae Dahuricae of 2 parts of Radix Angelicae Sinensis of Bombyx Batryticatus
1 part of Rhizoma Corydalis
Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, and 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1～3 bag, three to four times on the one, one month is a course of treatment.
Claims (6)
1, the prosopalgic Chinese patent medicine of a kind of treatment is characterized in that it is made by the following weight proportion raw material:
0.1～0.5 part of 1.5～6 parts of Herba Asari of 0.1～2 part of Rhizoma Chuanxiong of Arisaema Cum Bile
0.1～2 part of 1.5～6 parts of Pheretima of 0.1～1 part of Rhizoma Gastrodiae of Rhizoma Typhonii
0.1～2 part of 1.5～6 parts of Radix Angelicae Dahuricae of 1～4 part of Radix Angelicae Sinensis of Bombyx Batryticatus
0.1～2 part of Rhizoma Corydalis
2, the prosopalgic Chinese patent medicine of a kind of treatment according to claim 1, wherein the weight proportion of each raw material is:
0.2～0.4 part of 2.5～3.5 parts of Herba Asari of 0.5～1.5 part of Rhizoma Chuanxiong of Arisaema Cum Bile
0.5～1.5 part of 2.5～3.5 parts of Pheretima of 0.3～0.7 part of Rhizoma Gastrodiae of Rhizoma Typhonii
0.5～1.5 part of 2.5～3.5 parts of Radix Angelicae Dahuricae of 1.5～2.5 parts of Radix Angelicae Sinensis of Bombyx Batryticatus
0.5～1.5 part of Rhizoma Corydalis
3, the prosopalgic Chinese patent medicine of a kind of treatment according to claim 1, wherein the weight proportion of each raw material is:
0.3 part of 3 parts of Herba Asari of 1 part of Rhizoma Chuanxiong of Arisaema Cum Bile
1 part of 3 parts of Pheretima of 0.5 part of Rhizoma Gastrodiae of Rhizoma Typhonii
1 part of 3 parts of Radix Angelicae Dahuricae of 2 parts of Radix Angelicae Sinensis of Bombyx Batryticatus
1 part of Rhizoma Corydalis
4, the Chinese patent medicine of claim 1-3 is to be fit to medicinal various dosage forms.
5, the Chinese patent medicine of claim 4 is tablet, capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop, drop pill.
6, the Chinese patent medicine of claim 4 is capsule, tablet, granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100654833A CN101028451B (en) | 2007-04-16 | 2007-04-16 | Chinese medicine for treating tic douloureux |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100654833A CN101028451B (en) | 2007-04-16 | 2007-04-16 | Chinese medicine for treating tic douloureux |
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| Publication Number | Publication Date |
|---|---|
| CN101028451A true CN101028451A (en) | 2007-09-05 |
| CN101028451B CN101028451B (en) | 2010-04-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100654833A Expired - Fee Related CN101028451B (en) | 2007-04-16 | 2007-04-16 | Chinese medicine for treating tic douloureux |
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| CN (1) | CN101028451B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623193A (en) * | 2012-08-23 | 2014-03-12 | 李艳辉 | Traditional Chinese medicine composition capable of relieving illness of trigeminal neuralgia |
| CN104435778A (en) * | 2014-11-24 | 2015-03-25 | 李镇荣 | Medicine for treating facial neuralgia |
| CN106213922A (en) * | 2016-08-30 | 2016-12-14 | 陈彪 | One treats prosopalgic medicated pillow |
-
2007
- 2007-04-16 CN CN2007100654833A patent/CN101028451B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623193A (en) * | 2012-08-23 | 2014-03-12 | 李艳辉 | Traditional Chinese medicine composition capable of relieving illness of trigeminal neuralgia |
| CN104435778A (en) * | 2014-11-24 | 2015-03-25 | 李镇荣 | Medicine for treating facial neuralgia |
| CN106213922A (en) * | 2016-08-30 | 2016-12-14 | 陈彪 | One treats prosopalgic medicated pillow |
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| Publication number | Publication date |
|---|---|
| CN101028451B (en) | 2010-04-21 |
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