CN101028427B - Chinese-medicinal decoction for treating hives - Google Patents
Chinese-medicinal decoction for treating hives Download PDFInfo
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Abstract
A Chinese medicine in the form of decoction for treating urticaria is prepared from more than 10 Chinese-medicinal materials including rehmannia root, yam, anemarrhena rhizome, earthworm, etc.
Description
Technical field
The present invention relates to the urticarial Chinese medicine decoction of a kind of treatment, is that a kind of urticaria for the treatment of is the Chinese medicine decoction of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.
Background technology
Urticaria is owing to skin, the little vascular reactivity expansion of mucosa and permeability increase a kind of localized edema reaction that produces.Primary disease is more common, and the people of about 15%-25% was taken place once in life at least.The urticaria traditional Chinese medical science is called urticaria, rubella, red rash, miliaria alba, acute angioneurotic edema, urticaria etc.Be commonly called as terrible wind pimple, rubella wheal, bellows chamber etc.As says in " Standards of Diagnosis and Treatment air door " " the evil exopathogenic heat of husband is skin, meets wind and cold and hinders and then play urticaria, and overabundant heat is red complexion then, wind at most color certainly, very the person itches bitterly, that scratches then becomes skin ulcer." " urticaria person, the sound granule is had a nightmare among skin, the loathing of cold pruritus all over of generating heat and for example " surgery great achievement urticaria ".Classical prescription: exposure to the wind after sweating due to overstrain is a Cuo numbness.The little red complexion of heat, heat is darkish complexion very., control and should lung heat clearing fall expectorant and induce sweat at lung by expectorant heat.”
The urticaria clinical manifestation is the localized edema welt that differs in size.The welt color can be cerise, pale red, pale asphyxia or skin-color, and form can rounded, oval, annular or irregular shape.Welt can take place suddenly in several minutes, can disappear in several minutes to a few hours, did not stay any vestige, but this plays that again, outbreak repeatedly.Its Clinical symptoms is stepped back no vestige for taking place rapidly and disappearing, and itches with play.Severe patient can be with headache, dizziness, arthralgia, stomachache, nausea,vomiting,diarrhea, uncomfortable in chest, nervous, hoarseness, dyspnea, severe patient can occur that laryngeal edema, pale complexion, heart rate quicken, anaphylactic shock such as pulse is thin and delicate, blood pressure drops, confusion, threat to life.Clinical in course of disease length, generally anxious onset, the course of disease was called acute urticaria at three months with interior person, and its morbidity is hurried, the welt number is more, how with General Symptoms; Welt shows effect repeatedly and is called chronic urticaria above person more than three months, and is few for a long time during its welt, but most welt is less, and General Symptoms is lighter.
The common cause of disease of urticaria has: 1. food: as fish, shrimp, Eriocheir sinensis, egg or milk etc.2. medicine: penicillin, furazolidone, serum, vaccine etc.3. infect: tonsillitis, viral hepatitis, Enterozoa etc.4. animal and plant factor: as sucking scurf, feather or the pollen etc. of animal.5. physics and chemical factor: as hot and cold, daylight, friction and pressure etc.6. internal organs and general disease and nervously all can bring out primary disease.
Urticaria also has specific type urticaria, (1) peptone urticaria (acute protein anaphylaxis urticaria) except that being divided into acute urticaria and chronic urticaria.(2) cold urticaria is divided into again: familial cold urticaria and acquired cold urticaria.(3) heat urticaria.(4) cholinergic urticaria.(5) solar urticaria.(6) pressure urticaria.(7) aquagenic urticaria.(8) serum sickness urticaria.(9) autoimmunity Progesterone urticaria.(10) angioedema (huge urticaria).(11) factitial urticaria.Acute urticaria disappeared through a few days or several weeks, and reason is more easily traced, and disappeared rapidly after dispeling the cause of disease.Chronic urticaria is shown effect repeatedly, does not heal throughout the year.Cause of disease complexity is difficult to find out, lives, brings mentally very big misery and inconvenience to the patient.Serious symptom when its acute attack can cause the body gram that suffocates, threat to life.Therefore, the problem of relevant prevention minimizing chronic urticaria recurrence is the difficult point of present clinical treatment aspect.
The Chinese traditional treatment acute urticaria is single can to obtain good curative effect with treatment by Chinese herbs.Clinical syndrome differentiation is based on excess syndrome, heat syndrome, and common card has pattern of syndrome such as wind heat, blood hot air wind producing, the intestines and stomach be damp and hot, and ailment said due to cold or exposure is a main external cause, treats antipruritic based on dispelling wind; Be equipped with the medicine of relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, clearing away heat and cooling blood, heat clearing away purging FU-organs intestinal stasis relieving respectively.The chronic urticaria Chinese medical discrimination is many with deficiency syndrome, blood stasis syndrome.Common pattern of syndrome has: insufficiency of the spleen catching cold, weakened defensive QI; Deficiency of qi and blood; Give birth in the hepatic and renal YIN deficiency, wind syndrome caused by deficiency; Qi depression to blood stasis; Chong and Ren channel disorder etc.Treat respectively with invigorating the spleen and benefiting QI the cold expelling consolidating superficial resistance; Benefiting QI and nourishing blood, dispelling wind is antipruritic; Adjusting and reinforcing liver and kidney, nourishing blood to stop wind syndrome; Blood circulation promoting and blood stasis dispelling, dispelling wind for relieving itching; Regulating thoroughfare and controlling vessel is a method.
Doctor trained in Western medicine thinks that urticaria will prevent its recurrence, at first when finding clear and definite its cause of disease, is removed.But often the cause of disease is difficult to find clinically.So present western medical treatment is symptomatic treatment mostly.Traditional antihistaminic has stronger maincenter inhibition ability easily to produce the drowsiness side effect that waits, and the antihistaminic of a new generation does not have side effect such as drowsiness as astemizole, loratadine, cetirizine etc., and its short term effect is better, but late result is relatively poor.This is concerning treatment of Chronic Urticaria and reduce its relapse rate, and curative effect is often not ideal enough.
Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide the urticarial Chinese medicine decoction of a kind of treatment.Have determined curative effect, safe ready, have no side effect, cheap characteristics.
The present invention is made by the following weight proportion raw material:
1.5～6 parts of 1.5～6 parts of Rhizoma Anemarrhenaes of 1.5～6 parts of Radix Rehmanniae Preparata of Rhizoma Dioscoreae
1.0～4 parts of 1.0～4 parts of Radix Saposhnikoviaes of 1.0～4 parts of Cortex Moutans of Rhizoma Alismatis
0.1～2 part of 1.0～4 portions of Periostracum Cicadae of 1.0～4 parts of Folium Perillaes of Poria
0.1～2 part of 0.1～2 part of Pheretima of 1.0～4 portions of Bombyx Batryticatus of Cortex Phellodendri
The weight proportion of each raw material of optimization formula of the present invention is:
2.5～3.5 parts of 2.5～3.5 parts of Rhizoma Anemarrhenaes of 2.5～3.5 parts of Radix Rehmanniae Preparata of Rhizoma Dioscoreae
1.5～2.5 parts of 1.5～2.5 parts of Radix Saposhnikoviaes of 1.5～2.5 parts of Cortex Moutans of Rhizoma Alismatis
0.5～1.5 part of 1.5～2.5 portions of Periostracum Cicadae of 1.5～2.5 parts of Folium Perillaes of Poria
0.5～1.5 part of 0.5～1.5 part of Pheretima of 1.5～2.5 portions of Bombyx Batryticatus of Cortex Phellodendri
The weight proportion of each raw material of optimum formula of the present invention is:
3 parts of 3 parts of Rhizoma Anemarrhenaes of 3 parts of Radix Rehmanniae Preparata of Rhizoma Dioscoreae
2 parts of 2 parts of Radix Saposhnikoviaes of 2 parts of Cortex Moutans of Rhizoma Alismatis
1 part of 2 portions of Periostracum Cicadae of 2 parts of Folium Perillaes of Poria
1 part of 1 part of Pheretima of 2 portions of Bombyx Batryticatus of Cortex Phellodendri
Drug action mechanism among the present invention is as follows:
The Rhizoma Dioscoreae property of medicine is sweet, flat.Return spleen, lung, kidney channel.Have spleen reinforcing, support lung, reinforce the kidney, the effect that benefit is smart.Can treat diarrhea due to hypofunction of the spleen, the lack of appetite edema, cough and asthma due to lung deficiency is quenched one's thirst, seminal emission, leukorrhagia, the frequent micturition of suffering from a deficiency of the kidney.Carbuncle is controlled in external, scrofula etc.(the 218th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Radix Rehmanniae Preparata nature and flavor are sweet, tepor.Return liver, kidney channel.Have nourishing YIN and supplementing blood, beneficial essence is filled out the effect of marrow.Can treat the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair etc.(the 95th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Rhizoma Anemarrhenae nature and flavor hardship, sweet, cold.Return lung, stomach, kidney channel.Has clearing away heat-fire, the effect of promoting the production of body fluid and moisturizing.Can treat that fever caused by exogenous pathogenic factors, hyperpyrexia excessive thirst, tuberculosis heating, cough due to lung-heat, osteopyrexia and fever, interior-heat are quenched one's thirst, the dryness of the intestine constipation, dysuria, diabetes etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 817th page).
The Rhizoma Alismatis nature and flavor are sweet, cold.Return kidney, urinary bladder channel.Has diuresis, the effect of clearing away damp-heat.Can treat dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia etc.(the 184th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Cortex Moutan property of medicine hardship, suffering are slightly cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, the effect of promoting blood circulation to remove blood stasis.Can treat the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, the calentura later stage, hot Fu Yin divided heating, osteopyrexia and fever, and amenorrhea due to stagnation of blood, dysmenorrhea, mass in the abdomen, carbuncle sore tumefacting virus falls and pounces on the pain of injury, rheumatic arthralgia etc.(the 1578th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Radix Saposhnikoviae nature and flavor suffering, sweet, temperature.Return bladder, liver, spleen channel.Have inducing diaphoresis to dispel wind, win and wet, the effect of relieving convulsion.Can treat headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus etc.(the 117th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The Poria nature and flavor are sweet, flat, light.GUIXIN, lung, spleen, kidney channel.Has eliminating dampness and diuresis, the effect of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Can treat that dysuria, edema distension, phlegm retention cough with dyspnea, brain are throbbed with fear, have loose bowels in the loose stool, irritability, palpitation with fear, insomnia, forgetful, seminal emission, stranguria with turbid discharge, insufficiency of the spleen, stop that drink is not eaten, gastral cavity is vexed, three YIN malaria (malaria pathogen in three YIN) disease, heating do not heal, end empty YANG-depletion etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 898th page).
Folium Perillae property of medicine suffering, temperature.Return lung, spleen, stomach warp.Have expelling cold and relieving exterior syndrome, promoting the circulation of QI and reducing phlegm, antiabortive, solving toxin of fish and crab.Can treat wind and cold table disease, cough with copious phlegm, fullness in the epigastrium and chest, nausea and vomiting, stomachache is vomited and diarrhoea, nausea discord, pregnancy reactions, ichthyophagy Eriocheir sinensis poisoning etc.(the 3288th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Cortex Phellodendri nature and flavor hardship, cold.Return kidney, urinary bladder channel.Have heat clearing and damp drying, pathogenic fire purging removes steams, and the effect of skin ulcer is treated in detoxifcation.Can treat damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.The stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.Can treat hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency etc.(the 251st page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The Periostracum Cicadae nature and flavor are sweet, salty, cold.Return lung, Liver Channel.Has diffusing wind heat extraction, sore-throat relieving, rash, nebula removing, the effect of spasmolytic.Can treat anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, conjunctival congestion cataracta, convulsion with spasms, tetanus etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1254th page).
Bombyx Batryticatus property of medicine suffering, salty, flat.Return liver, lung, stomach warp.Have and expelling wind and relieving convulsion, dissipating phlegm and resolving masses, the effect of resolving toxin and disinhibiting the throat.Infantile convulsion be can treat and apoplexy facial hemiparalysis, migraine and general headache, laryngopharynx swelling and pain, scrofula, mumps, rubella, sore etc. twitched.(the 1021st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Pheretima nature and flavor are salty, cold.Go into liver, spleen, lung, urinary bladder channel.Have heat clearing away, suppressing the hyperactive liver, Zhichuan, collateral dredging diuretic effect.Cure mainly high fanatical dry, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pant, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection, hyperpyrexia, bronchial asthma, hypertension, psychosis, ulcer of the lower limb, eczema, erysipelas, burn and scald, fracture etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 522nd page).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Flos Lonicerae, Cortex Mori and Fructus Forsythiae; With Herba Houttuyniae, Fructus Arctii, Radix Isatidis, Herba Schizonepetae, Herba Spirodelae and Fructus Gardeniae is ministerial drug; With Periostracum Cicadae, Radix Arnebiae (Radix Lithospermi) and Concha Margaritifera is adjuvant.All medicines are harmonious, tool replenishing YIN and removing heat altogether, the effect of cooling blood, expelling wind.The treatment urticaria has determined curative effect, has no side effect taking convenience, cheap characteristics.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment urticaria of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.
3, the present invention not only can effectively treat urticaria, and urticarial prevention is also had good effect, and the treatment urticaria has determined curative effect, has no side effect taking convenience, cheap characteristics.
Further specify medicine of the present invention to treating urticarial therapeutic effect below by the clinical practice example.The urticaria curative effect determinate standard: 1. cure: welt disappears, and clinical sign disappears, and the person does not reaccess.2. take a turn for the better: welt disappear 30% or the back recurrent interval time that disappears prolong sx persons such as pruritus.3. do not heal: welt and pruritus do not have obvious improver, or the less than 30% that disappears.(the 859th page of chief editor's " traditional Chinese medical science disease diagnosis and treatment standard and prescription are selected for use " People's Health Publisher's calendar year 2001 version such as Dai Shen).
For showing medicine of the present invention, as follows through clinical test results to treating urticarial therapeutic effect; Treatment urticaria patient 39 examples, male's 20 examples, women's 19 examples, the age is 18～60 years old.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.31 examples of fully recovering account for 79.5%, and 5 examples that take a turn for the better account for 12.82%, and more 3 examples do not account for 7.69%, and total effective rate reaches 92.31%.After three course of therapy, symptoms such as patient's welt and pruritus all have clear improvement or fully recover.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
The embodiment decoction takes by weighing raw material by following weight:
3 parts of 3 parts of Rhizoma Anemarrhenaes of 3 parts of Radix Rehmanniae Preparata of Rhizoma Dioscoreae
2 parts of 2 parts of Radix Saposhnikoviaes of 2 parts of Cortex Moutans of Rhizoma Alismatis
1 part of 2 portions of Periostracum Cicadae of 2 parts of Folium Perillaes of Poria
1 part of 1 part of Pheretima of 2 portions of Bombyx Batryticatus of Cortex Phellodendri
Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The urticaria decoction plastic packaging that the present invention makes is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.One month is a course of treatment.
Claims (3)
1. urticarial Chinese medicine decoction of treatment is characterized in that it is made by following raw materials by weight proportions:
1.5～6 parts of 1.5～6 parts of Rhizoma Anemarrhenaes of 1.5～6 parts of Radix Rehmanniae Preparata of Rhizoma Dioscoreae
1.0～4 parts of 1.0～4 parts of Radix Saposhnikoviaes of 1.0～4 parts of Cortex Moutans of Rhizoma Alismatis
0.1～2 part of 1.0～4 portions of Periostracum Cicadae of 1.0～4 parts of Folium Perillaes of Poria
0.1～2 part of 0.1～2 part of Pheretima of 1.0～4 portions of Bombyx Batryticatus of Cortex Phellodendri.
2. the urticarial Chinese medicine decoction of a kind of treatment according to claim 1, wherein the weight proportion of each crude drug is:
2.5～3.5 parts of 2.5～3.5 parts of Rhizoma Anemarrhenaes of 2.5～3.5 parts of Radix Rehmanniae Preparata of Rhizoma Dioscoreae
1.5～2.5 parts of 1.5～2.5 parts of Radix Saposhnikoviaes of 1.5～2.5 parts of Cortex Moutans of Rhizoma Alismatis
0.5～1.5 part of 1.5～2.5 portions of Periostracum Cicadae of 1.5～2.5 parts of Folium Perillaes of Poria
0.5～1.5 part of 0.5～1.5 part of Pheretima of 1.5～2.5 portions of Bombyx Batryticatus of Cortex Phellodendri.
3. the urticarial Chinese medicine decoction of a kind of treatment according to claim 1, wherein the weight proportion of each crude drug is:
3 parts of 3 parts of Rhizoma Anemarrhenaes of 3 parts of Radix Rehmanniae Preparata of Rhizoma Dioscoreae
2 parts of 2 parts of Radix Saposhnikoviaes of 2 parts of Cortex Moutans of Rhizoma Alismatis
1 part of 2 portions of Periostracum Cicadae of 2 parts of Folium Perillaes of Poria
1 part of 1 part of Pheretima of 2 portions of Bombyx Batryticatus of Cortex Phellodendri.
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