Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide the psoriatic Chinese medicine preparation of a kind of treatment, and have determined curative effect, safe ready, little, the cheap characteristics of side effect.
The present invention is made by the following weight proportion raw material:
2.5~10 parts of 2.5~10 parts of Radix Rehmanniae of 5~20 parts of Fructus Gardeniae (parched) of Radix Scutellariae
1.5~6 parts of 1.5~6 parts of stir-baked CORTEX PHELLODENDRI with salt solution of 1.5~6 portions of Radix Gentianaes of Rhizoma Coptidis
1.5~6 parts of 1.5~6 portions of Herba Violaes of 1.5~6 parts of Herba Taraxacis of Herba Artemisiae Scopariae
1~4 part of 1.5~6 parts of Cortex Moutan of 1.5~6 parts of stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution of Radix Paeoniae Rubra
The weight proportion of each raw material of optimization formula of the present invention is:
3~7 parts of 3~7 parts of Radix Rehmanniae of 8~12 parts of Fructus Gardeniae (parched) of Radix Scutellariae
2~4 parts of 2~4 parts of stir-baked CORTEX PHELLODENDRI with salt solution of 2~4 portions of Radix Gentianaes of Rhizoma Coptidis
2~4 parts of 2~4 portions of Herba Violaes of 2~4 parts of Herba Taraxacis of Herba Artemisiae Scopariae
1.5~2.5 parts of 2~4 parts of Cortex Moutans of 2~4 parts of stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution of Radix Paeoniae Rubra
The weight proportion of each raw material of optimum formula of the present invention is:
5 parts of 5 parts of Radix Rehmanniae of 10 parts of Fructus Gardeniae (parched) of Radix Scutellariae
3 parts of 3 parts of stir-baked CORTEX PHELLODENDRI with salt solution of 3 portions of Radix Gentianaes of Rhizoma Coptidis
3 parts of 3 portions of Herba Violaes of 3 parts of Herba Taraxacis of Herba Artemisiae Scopariae
2 parts of 3 parts of Cortex Moutans of 3 parts of stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution of Radix Paeoniae Rubra
Drug action mechanism among the present invention is as follows:
Radix Scutellariae nature and flavor hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect.Can treat hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement etc.(the 248th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Fructus Gardeniae (parched) nature and flavor hardship, cold.GUIXIN, lung, tri-jiao channel.Has the pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, the effect of removing pathogenic heat from blood and toxic substance from the body.It is vexed to treat calentura, the jaundice dark coloured urine, and blood strangury and dry pain, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain etc.(the 202nd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The Radix Rehmanniae nature and flavor are sweet, cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.Can treat that calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, interior-heat are quenched one's thirst, haematemesis, epistaxis, send out speckle dermexanthesis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 514th page).
Radix Gentianae nature and flavor hardship, cold.Return liver, gallbladder meridian.Have eliminating pathogen in the liver gallbladder fire, the clear part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is wet, relieving convulsion making eye bright, and the malaria protozoon is good for the stomach, the effect that protects the liver.Can treat that Liver Channel intenseness of heat, infantile convulsion are manic, encephalitis B, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, the swollen skin infection of pain, scrotum swell and ache, pudendum pruritus due to damp pathogen, hypertension dizziness tinnitus, chest and hypochondrium, acute infectious hepatitis, cystitis, skin infection swell and ache etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 413rd page).
Rhizoma Coptidis nature and flavor hardship, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Has heat clearing and damp drying, the effect of eliminating fire and detoxication.It is full to treat damp and hot spleen, the vomiting acid regurgitation, and dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache is quenched one's thirst, and carbuncle is treated skin ulcer etc.(the 251st page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Stir-baked CORTEX PHELLODENDRI with salt solution nature and flavor hardship, cold.Return kidney, urinary bladder channel.Have heat clearing and damp drying, pathogenic fire purging removes steams, and the effect of skin ulcer is treated in detoxifcation.Can treat damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.The stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.Can treat hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency etc.(the 251st page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Herba Artemisiae Scopariae nature and flavor hardship, suffering are slightly cold.Return spleen, stomach, liver, gallbladder meridian.Has clearing away damp-heat, the effect of jaundice eliminating subcutaneous ulcer.Can treat the jaundice oliguria, the eczema pruritus; Infectious jaundice type hepatitis etc.(the 192nd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Radix Paeoniae Rubra nature and flavor suffering, hardship, flavor are trembled with fear.Return Liver Channel.Has clearing away heat and cooling blood, the effect of eliminating stasis to stop pain.Can treat maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, traumatic injury, carbuncle skin infection etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 659th page).
Herba Taraxaci nature and flavor hardship, sweet, cold.Return liver, stomach warp.Has heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the effect of inducing diuresis for treating stranguria syndrome.Can treat furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria etc.(the 290th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Herba Violae nature and flavor hardship, cold.GUIXIN, Liver Channel.Has clearing away heat-damp and promoting diuresis, the effect of removing toxic substances and promoting subsidence of swelling.Can treat furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom etc.(" Chinese medicine dictionary " the 800th page).
Stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution nature and flavor hardship, sweet, cold.Return lung, stomach, kidney channel.Has clearing away heat-fire, the effect of promoting the production of body fluid and moisturizing.Can treat that fever caused by exogenous pathogenic factors, hyperpyrexia excessive thirst, tuberculosis heating, cough due to lung-heat, osteopyrexia and fever, interior-heat are quenched one's thirst, the dryness of the intestine constipation, dysuria, diabetes etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 817th page).
Cortex Moutan nature and flavor hardship, suffering are slightly cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, the effect of blood circulation promoting and blood stasis dispelling.Can treat maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, the amenorrhea dysmenorrhea, carbuncle sore tumefacting virus falls and pounces on the pain of injury etc.(the 137th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Radix Scutellariae, Fructus Gardeniae (parched) and Radix Rehmanniae, is ministerial drug with Radix Gentianae, Rhizoma Coptidis, stir-baked CORTEX PHELLODENDRI with salt solution, Herba Artemisiae Scopariae, Radix Paeoniae Rubra, Herba Taraxaci, Herba Violae and stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, is adjuvant with Cortex Moutan.All medicine phases and the effect that is total to tool heat clearing and damp drying, eliminating fire and detoxication, YIN nourishing and the production of body fluid promoting, skin moistening speckle removing, the treatment psoriasis has determined curative effect, has no side effect taking convenience, cheap characteristics.
Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, preferred Chinese medicine preparation is a peroral dosage form, as: tablet, capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment and the prevention psoriasis of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.
3, the present invention not only can effectively treat psoriasis, and psoriatic prevention is also had good effect, has improved patient's life quality greatly, and higher healing rehabilitation efficacy is arranged.
Further specify medicine of the present invention to treating psoriatic therapeutic effect below by the clinical practice example.
Psoriasis curative effect determinate standard (the 302nd page of " new Chinese medicine clinical research guideline " Zheng Xiao cornel chief editor Chinese Medicine science and technology publishing house in May, 2002 front page).
1, clinical recovery tcm clinical practice symptom, sign disappear or basic the disappearance; The sign integration reduces 〉=95%.
2, produce effects tcm clinical practice symptom, sign are obviously improved, and 95%>sign integration reduces 〉=70%.
3, effectively tcm clinical practice symptom, sign all take a favorable turn, and 70%>sign integration reduces 〉=50%.
4, invalid tcm clinical practice symptom, sign all do not have obvious improvement, even increase the weight of, the sign integration reduces less than 50%.
As follows through clinical test results; Treatment psoriatic 85 examples, male's 56 examples, women's 29 examples, the age is 18~65 years old.Take embodiment 1 capsule, each 2-10 grain, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.Two months is a course of treatment, take continuously three the course of treatment observe the curative effect.66 examples of fully recovering account for 77.6%, and produce effects 6 examples account for 7.05%, and effective 10 examples account for 11.76%, and invalid 3 examples account for 3.52%, and total effective rate reaches 96.48%.After three course of therapy, symptoms such as patient's erythema, pimple and squama etc. all have clear improvement.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
Embodiment 1 capsule takes by weighing raw material by following weight:
5 parts of 5 parts of Radix Rehmanniae of 10 parts of Fructus Gardeniae (parched) of Radix Scutellariae
3 parts of 3 parts of stir-baked CORTEX PHELLODENDRI with salt solution of 3 portions of Radix Gentianaes of Rhizoma Coptidis
3 parts of 3 portions of Herba Violaes of 3 parts of Herba Taraxacis of Herba Artemisiae Scopariae
2 parts of 3 parts of Cortex Moutans of 3 parts of stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution of Radix Paeoniae Rubra
Preparation method is to get raw materials such as Radix Scutellariae, Fructus Gardeniae (parched), Radix Rehmanniae, Radix Gentianae, Rhizoma Coptidis, stir-baked CORTEX PHELLODENDRI with salt solution, Herba Artemisiae Scopariae, Radix Paeoniae Rubra, Herba Taraxaci, Herba Violae, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution and Cortex Moutan to decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, the clear paste of relative density 1.08~1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree~55 are concentrated into the clear paste of relative density 1.30~1.32, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2~10, three to four times on the one, two months is a course of treatment.
Embodiment 2 tablets take by weighing raw material by following weight:
5 parts of 5 parts of Radix Rehmanniae of 10 parts of Fructus Gardeniae (parched) of Radix Scutellariae
3 parts of 3 parts of stir-baked CORTEX PHELLODENDRI with salt solution of 3 portions of Radix Gentianaes of Rhizoma Coptidis
3 parts of 3 portions of Herba Violaes of 3 parts of Herba Taraxacis of Herba Artemisiae Scopariae
2 parts of 3 parts of Cortex Moutans of 3 parts of stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution of Radix Paeoniae Rubra
Preparation method is to get Radix Scutellariae, Fructus Gardeniae (parched), Radix Rehmanniae, Radix Gentianae, Rhizoma Coptidis, stir-baked CORTEX PHELLODENDRI with salt solution, Herba Artemisiae Scopariae, Radix Paeoniae Rubra, Herba Taraxaci, Herba Violae, raw material such as stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution and Cortex Moutan decocts with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, the clear paste of relative density 1.08~1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree~55 are concentrated into the clear paste of relative density 1.30~1.32, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2~10, three to four times on the one, two months is a course of treatment.
Embodiment 3 granules take by weighing raw material by following weight:
5 parts of 5 parts of Radix Rehmanniae of 10 parts of Fructus Gardeniae (parched) of Radix Scutellariae
3 parts of 3 parts of stir-baked CORTEX PHELLODENDRI with salt solution of 3 portions of Radix Gentianaes of Rhizoma Coptidis
3 parts of 3 portions of Herba Violaes of 3 parts of Herba Taraxacis of Herba Artemisiae Scopariae
2 parts of 3 parts of Cortex Moutans of 3 parts of stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution of Radix Paeoniae Rubra
Preparation method is to get Radix Scutellariae, Fructus Gardeniae (parched), Radix Rehmanniae, Radix Gentianae, Rhizoma Coptidis, stir-baked CORTEX PHELLODENDRI with salt solution, Herba Artemisiae Scopariae, Radix Paeoniae Rubra, Herba Taraxaci, Herba Violae, raw material such as stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution and Cortex Moutan decocts with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, and the clear paste of relative density 1.08~1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when 50 degree~55 are spent, be concentrated into the clear paste of relative density 1.30~1.32, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1~3 bag, three to four times on the one, two months is a course of treatment.