CN101028419A - Chinese-medicinal preparation for treating nongonococcal urethritis - Google Patents
Chinese-medicinal preparation for treating nongonococcal urethritis Download PDFInfo
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- CN101028419A CN101028419A CN 200710065485 CN200710065485A CN101028419A CN 101028419 A CN101028419 A CN 101028419A CN 200710065485 CN200710065485 CN 200710065485 CN 200710065485 A CN200710065485 A CN 200710065485A CN 101028419 A CN101028419 A CN 101028419A
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Abstract
A Chinese medicine for treating non-gonorrheal urethritis is prepared from 10 Chinese-medicinal materials including pyrrosia leaf common knot-grass, China root, plantain seed, etc.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of nongonococcal urethritis, is that a kind of nongonococcal urethritis for the treatment of is the Chinese patent medicine of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.
Background technology
Nongonococcal urethritis is the urethritis that is caused by other pathogen beyond the Diplococcus gonorrhoeae, it is a kind of sexually transmitted disease (STD), the performance of urethritis is arranged clinically, but in urethral secretions, can not find out gonococcus, wherein also comprise the persistent gonorrhea posterior urethritis of gonorrhea healing back symptom.Because the women not only has the inflammation of urethra when suffering from primary disease, and the inflammation of reproductive tract such as cervicitis is arranged, therefore can be described as again " non-gonococcal urogenital infections ".Main clinical manifestation is urethral orifice discomfort, dysurea, urgent micturition, dysuria, and the visible leucorrhea of women is many etc.Find that in clinical because Drug resistance, the broad ectrum antibiotic therapeutic effect is more and more lower.
Nongonococcal urethritis belongs to the traditional Chinese medical science " stranguria ", " it is turbid to drown ", " nebulousurine ", and the women then belongs to " leukorrhagia ", " pudendal pruritus " etc.
Chinese medicine thinks that nongonococcal urethritis and sexual life are unclean, directly or indirectly experiences special foul heresy, leads to damp and hotly, and the damp and hot malicious heresy knot of fighting is invaded the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, the multiple abscess bladder, and the smoked urethra that burns, and make bladder qi dysfunction, and disturbance in water passage, urinary catheter (road) blocks relevant; Or because of stagnation of QI due to depression of the liver, with the passing of time strongly fragrant and fire-transformation is invaded bladder down, makes gasification not all right, disturbance in water passage and be pouring; Also can be because of impairment of the kidney due to indulgence in sexual activities or damp and hot evil poison by the internal organs superinverse to dirty, injure kidney qi, the prolonged illness imapirment of the spleen and stomach, deficiency of spleen and stomach, it is not normal to gasify, and can not take the photograph to receive fat and stranguria with turbid discharge.The state of an illness is with the passing of time then drenched body void for a long time, and impairment caused by overstrain is excessive, or poison of drug hinders, and decreases cloudy consumption gas so that deficiency of spleen and stomach, and functioning of bladder is had no right, and damp is loved for a long time.The traditional Chinese medical science is divided at the treatment nongonococcal urethritis: the dialectical treatments of disease type such as damp invasion of lower energizer, stagnation of QI due to depression of the liver, the hepatic and renal YIN deficiency, deficiency of spleen and stomach obtain effect preferably, and do not recur.
Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of nongonococcal urethritis.Have determined curative effect, safe ready, have no side effect, cheap characteristics.
The present invention is made by the following weight proportion raw material:
1.5～6 parts of Folium Pyrrosiaes of Rhizoma Smilacis Glabrae, 1.5～6 Fen pivots hold 1.5～6 parts
0.1～2 part of 1.5～6 portions of Rhizoma Alismatis of 1.0～4 portions of Herba Dianthis of Flos Lonicerae
0.1～2 part of 0.1～2 portion of Semen Plantaginis of 1.0～4 portions of Cortex Phellodendris of Fructus Gardeniae (parched)
0.1～2 part of Radix Et Rhizoma Rhei
The weight proportion of each raw material of optimization formula of the present invention is:
2.5～3.5 parts of Folium Pyrrosiaes of Rhizoma Smilacis Glabrae, 2.5～3.5 Fen pivots hold 2.5～3.5 parts
0.5～1.5 part of 2.5～3.5 portions of Rhizoma Alismatis of 1.5～2.5 portions of Herba Dianthis of Flos Lonicerae
0.5～1.5 part of 0.5～1.5 portion of Semen Plantaginis of 1.5～2.5 portions of Cortex Phellodendris of Fructus Gardeniae (parched)
0.5～1.5 part of Radix Et Rhizoma Rhei
The weight proportion of each raw material of optimum formula of the present invention is:
3 parts of Folium Pyrrosiaes of Rhizoma Smilacis Glabrae, 3 Fen pivots hold 3 parts
1 part of 3 portions of Rhizoma Alismatis of 2 portions of Herba Dianthis of Flos Lonicerae
1 part of 1 portion of Semen Plantaginis of 2 portions of Cortex Phellodendris of Fructus Gardeniae (parched)
1 part of Radix Et Rhizoma Rhei
Drug action mechanism among the present invention is as follows:
The Rhizoma Smilacis Glabrae nature and flavor are sweet, light, flat.Return liver, stomach warp.Has heat-clearing and toxic substances removing, wind-damp dispelling, bone and muscle strengthening, sharp joint, anticancer effect.Can treat damp and hot sore, eczema, rheumatic ostalgia, limbs contracture, Fructus Myricae rubrae malignant boil, urinary system infection, syphilis, stranguria with turbid discharge, stranguria leucorrhea, dyspepsia, diarrhoea, beriberi, furuncle, carbuncle, scrofula etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 87th page).
The Folium Pyrrosiae nature and flavor are sweet, bitter, be slightly cold.Return lung, urinary bladder channel.Has inducing diuresis for treating stranguria syndrome, the effect of clearing away heat to stop bleeding.Be used for pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction, drench the puckery pain of drop, spit blood epistaxis, hematuria, metrorrhagia, dyspnea and cough due to lung-heat etc.(the 68th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Herba Polygoni Avicularis nature and flavor hardship is slightly cold.Return urinary bladder channel.Has inducing diuresis for treating stranguria syndrome, parasite killing, itching relieving effect.Can treat the bladder pyretic stranguria, oliguria with reddish urine drenches the puckery pain of drop, skin eczema, pudendal pruritus leukorrhagia etc.(the 275th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The Flos Lonicerae nature and flavor are sweet, cold.Return lung, the heart, stomach warp.Has heat-clearing and toxic substances removing, the effect of wind-heat dissipating.Can treat the carbuncle furuncle, scrofula anal fistula, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 830th page).
Herba Dianthi nature and flavor hardship, cold.GUIXIN, small intestine meridian.Has the effect that inducing diuresis for treating stranguria syndrome, removing blood stasis stimulate the menstrual flow.Can treat pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction is drenched the puckery pain of drop, menstruation apolipsis etc.(the 316th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The Rhizoma Alismatis nature and flavor are sweet, cold.Return kidney, urinary bladder channel.Has diuresis, the effect of clearing away damp-heat.Can treat dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia etc.(Chinese Pharmacopoeia Commission compiles the 184th page of chemical industry of Pharmacopoeia of the People's Republic of China version in 2000 and publishes
Fructus Gardeniae (parched) nature and flavor hardship, cold.GUIXIN, lung, tri-jiao channel.Effect with pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, cool thermal detoxification.Can treat that calentura restlessness of asrhenia type and insomnia, calentura are vexed, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tell nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles, external treatment bruise pain etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 865th page).
Cortex Phellodendri nature and flavor hardship, cold.Return kidney, urinary bladder channel.Have heat clearing and damp drying, pathogenic fire purging removes steams, and the effect of skin ulcer is treated in detoxifcation.Can treat damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.The stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.Can treat hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency etc.(the 251st page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The Semen Plantaginis nature and flavor are sweet, be slightly cold.Return liver, kidney, lung, small intestinal, urinary bladder channel.Has clearing away heat and promoting diuresis, eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, the effect of removing heat from the lung and dissipating phlegm.Can treat the cough due to lung-heat, urinary system infection, calculus, gastritis edema, dysuria, enteritis, bacillary dysentery, acute icterohepatitisshock, bronchitis, acute eye conjunctivitis, stranguria with turbid discharge, leukorrhagia, hematuria, edema, hematodiarrhoea is had loose bowels, epistaxis, conjunctival congestion and swelling pain, sore throat tonsillitis, cough, skin ulcer etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 291st page).
Radix Et Rhizoma Rhei nature and flavor hardship, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Has purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, the effect of eliminating blood stasis and inducing menstruation.Can treat the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire, upper gastrointestinal hemorrhage etc.(the 19th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Rhizoma Smilacis Glabrae, Folium Pyrrosiae, Herba Dianthi and Herba Polygoni Avicularis; With Flos Lonicerae, Fructus Gardeniae (parched), Radix Et Rhizoma Rhei and Cortex Phellodendri is ministerial drug; With Rhizoma Alismatis and Semen Plantaginis is adjuvant.All medicines are harmonious, and are total to the tool heat-clearing and toxic substances removing, the effect of relieving stranguria by diuresis.The treatment nongonococcal urethritis has determined curative effect, has no side effect taking convenience, cheap characteristics.
Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.
Preparation of the present invention, preferably peroral dosage form is as tablet, capsule, oral liquid, buccal tablet, granule, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment nongonococcal urethritis of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.
3, the present invention treats nongonococcal urethritis and has determined curative effect, has no side effect taking convenience, cheap characteristics.
Further specify the therapeutic effect of medicine of the present invention below by the clinical practice example to the treatment nongonococcal urethritis.
For showing the therapeutic effect of medicine of the present invention, as follows through clinical test results to the treatment nongonococcal urethritis; Treatment nongonococcal urethritis patient 36 examples.Take embodiment 3 granules, each 1～3 bag, three to four times on the one, boiled water is taken after mixing it with water, and take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.Cure 31 examples and account for 86.11%, more 5 examples do not account for 13.89%, and total effective rate reaches more than 86%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
Embodiment 1 capsule takes by weighing raw material by following weight:
3 parts of 3 parts of Herba Polygoni Avicularis of 3 parts of Folium Pyrrosiaes of Rhizoma Smilacis Glabrae
1 part of 3 portions of Rhizoma Alismatis of 2 portions of Herba Dianthis of Flos Lonicerae
1 part of 1 portion of Semen Plantaginis of 2 portions of Cortex Phellodendris of Fructus Gardeniae (parched)
1 part of Radix Et Rhizoma Rhei
Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, and 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.
Embodiment 2 tablets take by weighing raw material by following weight:
3 parts of 3 parts of Herba Polygoni Avicularis of 3 parts of Folium Pyrrosiaes of Rhizoma Smilacis Glabrae
1 part of 3 portions of Rhizoma Alismatis of 2 portions of Herba Dianthis of Flos Lonicerae
1 part of 1 portion of Semen Plantaginis of 2 portions of Cortex Phellodendris of Fructus Gardeniae (parched)
1 part of Radix Et Rhizoma Rhei
Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.
Embodiment 3 granules take by weighing raw material by following weight:
3 parts of 3 parts of Herba Polygoni Avicularis of 3 parts of Folium Pyrrosiaes of Rhizoma Smilacis Glabrae
1 part of 3 portions of Rhizoma Alismatis of 2 portions of Herba Dianthis of Flos Lonicerae
1 part of 1 portion of Semen Plantaginis of 2 portions of Cortex Phellodendris of Fructus Gardeniae (parched)
1 part of Radix Et Rhizoma Rhei
Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, and 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1～3 bag, three to four times on the one, one month is a course of treatment.
Claims (6)
1, a kind of Chinese medicine preparation for the treatment of nongonococcal urethritis is characterized in that it is made by the following weight proportion raw material:
1.5～6 parts of 1.5～6 parts of Herba Polygoni Avicularis of 1.5～6 parts of Folium Pyrrosiaes of Rhizoma Smilacis Glabrae
0.1～2 part of 1.5～6 portions of Rhizoma Alismatis of 1.0～4 portions of Herba Dianthis of Flos Lonicerae
0.1～2 part of 0.1～2 portion of Semen Plantaginis of 1.0～4 portions of Cortex Phellodendris of Fructus Gardeniae (parched)
0.1～2 part of Radix Et Rhizoma Rhei
2, a kind of Chinese medicine preparation for the treatment of nongonococcal urethritis according to claim 1, wherein the weight proportion of each raw material is:
2.5～3.5 parts of 2.5～3.5 parts of Herba Polygoni Avicularis of 2.5～3.5 parts of Folium Pyrrosiaes of Rhizoma Smilacis Glabrae
0.5～1.5 part of 2.5～3.5 portions of Rhizoma Alismatis of 1.5～2.5 portions of Herba Dianthis of Flos Lonicerae
0.5～1.5 part of 0.5～1.5 portion of Semen Plantaginis of 1.5～2.5 portions of Cortex Phellodendris of Fructus Gardeniae (parched)
0.5～1.5 part of Radix Et Rhizoma Rhei
3, a kind of Chinese medicine preparation for the treatment of nongonococcal urethritis according to claim 1, wherein the weight proportion of each raw material is:
3 parts of 3 parts of Herba Polygoni Avicularis of 3 parts of Folium Pyrrosiaes of Rhizoma Smilacis Glabrae
1 part of 3 portions of Rhizoma Alismatis of 2 portions of Herba Dianthis of Flos Lonicerae
1 part of 1 portion of Semen Plantaginis of 2 portions of Cortex Phellodendris of Fructus Gardeniae (parched)
1 part of Radix Et Rhizoma Rhei
4, the Chinese medicine preparation of claim 1-3 is to be fit to medicinal various dosage forms.
5, the Chinese medicine preparation of claim 4 is tablet, capsule, oral liquid, buccal tablet, granule, pill, powder, suspensoid, powder, solution, drop, drop pill.
6, the Chinese medicine preparation of claim 4 is capsule, tablet, granule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200710065485 CN101028419A (en) | 2007-04-16 | 2007-04-16 | Chinese-medicinal preparation for treating nongonococcal urethritis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200710065485 CN101028419A (en) | 2007-04-16 | 2007-04-16 | Chinese-medicinal preparation for treating nongonococcal urethritis |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755559A (en) * | 2012-07-28 | 2012-10-31 | 赵新莲 | Traditional Chinese medicine composition for treating non-gonococcal urethritis |
| CN102920950A (en) * | 2012-10-29 | 2013-02-13 | 李永辉 | Traditional Chinese medicine preparation for curing gonococcal urethritis |
| CN102920856A (en) * | 2012-11-06 | 2013-02-13 | 唐光红 | Nine-ingredient stranguria-treating toxin-vanquishing decoction |
| CN102018790B (en) * | 2009-09-11 | 2013-07-10 | 叶景华 | Composition for curing urinary tract infection |
| CN104083655A (en) * | 2014-06-27 | 2014-10-08 | 项孝泓 | Traditional Chinese medicine composition for treating non-gonococcal urethritis |
| CN104083684A (en) * | 2014-07-24 | 2014-10-08 | 胡春英 | Traditional Chinese medicine for treating damp-heat downward flow type non-gonococcal urethritis |
| CN104274703A (en) * | 2014-10-20 | 2015-01-14 | 卞毓平 | Traditional Chinese medicine composition for treating urethritis as well as preparation method and application thereof |
| CN105079572A (en) * | 2015-09-19 | 2015-11-25 | 南京正亮医药科技有限公司 | Pharmaceutical preparation for treating non-gonococcal urethritis |
-
2007
- 2007-04-16 CN CN 200710065485 patent/CN101028419A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018790B (en) * | 2009-09-11 | 2013-07-10 | 叶景华 | Composition for curing urinary tract infection |
| CN102755559A (en) * | 2012-07-28 | 2012-10-31 | 赵新莲 | Traditional Chinese medicine composition for treating non-gonococcal urethritis |
| CN102755559B (en) * | 2012-07-28 | 2013-10-23 | 赵新莲 | Traditional Chinese medicine composition for treating non-gonococcal urethritis |
| CN102920950A (en) * | 2012-10-29 | 2013-02-13 | 李永辉 | Traditional Chinese medicine preparation for curing gonococcal urethritis |
| CN102920950B (en) * | 2012-10-29 | 2016-02-17 | 李永辉 | A kind of Chinese medicine preparation for the treatment of gonococcal urethritis |
| CN102920856A (en) * | 2012-11-06 | 2013-02-13 | 唐光红 | Nine-ingredient stranguria-treating toxin-vanquishing decoction |
| CN104083655A (en) * | 2014-06-27 | 2014-10-08 | 项孝泓 | Traditional Chinese medicine composition for treating non-gonococcal urethritis |
| CN104083684A (en) * | 2014-07-24 | 2014-10-08 | 胡春英 | Traditional Chinese medicine for treating damp-heat downward flow type non-gonococcal urethritis |
| CN104274703A (en) * | 2014-10-20 | 2015-01-14 | 卞毓平 | Traditional Chinese medicine composition for treating urethritis as well as preparation method and application thereof |
| CN105079572A (en) * | 2015-09-19 | 2015-11-25 | 南京正亮医药科技有限公司 | Pharmaceutical preparation for treating non-gonococcal urethritis |
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Open date: 20070905 |