Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide the psoriatic Chinese medicine preparation of a kind of treatment, and have determined curative effect, safe ready, little, the cheap characteristics of side effect.
The present invention is made by the following weight proportion raw material:
2.5~10 parts of 2.5~10 parts of Radix Scutellariaes of 5~20 parts of Rhizoma Smilacis Glabraes of Radix Rehmanniae
1.5~6 parts of 1.5~6 parts of Radix Paeoniae Rubra of 2.5~10 parts of Radix Angelicae Sinensis (processed with wine) of Folium Isatidis
1.5~6 parts of 1.5~6 parts of Radix Sophorae Flavescentiss of 1.5~6 portions of Caulis Spatholobis of wine Zaocys
1~4 part of 1~4 portion of Radix Scrophulariae of 1.5~6 parts of Fructus Kochiae of Cortex Dictamni.
The weight proportion of each raw material of optimization formula of the present invention is:
3~7 parts of 3~7 parts of Radix Scutellariaes of 8~12 parts of Rhizoma Smilacis Glabraes of Radix Rehmanniae
2.5~3.5 parts of 2.5~3.5 parts of Radix Paeoniae Rubra of 3~7 parts of Radix Angelicae Sinensis (processed with wine) of Folium Isatidis
2.5~3.5 parts of 2.5~3.5 parts of Radix Sophorae Flavescentiss of 2.5~3.5 portions of Caulis Spatholobis of wine Zaocys
1.5~2.5 parts of 1.5~2.5 portions of Radix Scrophulariaes of 2.5~3.5 parts of Fructus Kochiae of Cortex Dictamni.
The weight proportion of each raw material of optimum formula of the present invention is:
5 parts of 5 parts of Radix Scutellariaes of 10 parts of Rhizoma Smilacis Glabraes of Radix Rehmanniae
3 parts of 3 parts of Radix Paeoniae Rubra of 5 parts of Radix Angelicae Sinensis (processed with wine) of Folium Isatidis
3 parts of 3 parts of Radix Sophorae Flavescentiss of 3 portions of Caulis Spatholobis of wine Zaocys
2 parts of 2 portions of Radix Scrophulariaes of 3 parts of Fructus Kochiae of Cortex Dictamni.
Drug action mechanism among the present invention is as follows:
The Radix Rehmanniae nature and flavor are sweet, cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.Can treat that calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, interior-heat are quenched one's thirst, haematemesis, epistaxis, send out speckle dermexanthesis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 514th page).
The Rhizoma Smilacis Glabrae nature and flavor are sweet, light, flat.Return liver, stomach warp.Has heat-clearing and toxic substances removing, wind-damp dispelling, bone and muscle strengthening, sharp joint, anticancer effect.Can treat damp and hot sore, eczema, rheumatic ostalgia, limbs contracture, Fructus Myricae rubrae malignant boil, urinary system infection, syphilis, stranguria with turbid discharge, stranguria leucorrhea, dyspepsia, diarrhoea, beriberi, furuncle, carbuncle, scrofula etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 87th page).
Folium Isatidis nature and flavor hardship, cold.Return liver, the heart, stomach warp.Has heat-clearing and toxic substances removing, the effect of blood cooling and ecchymoses removing.Can treat epidemic febrile disease intenseness of heat excessive thirst, send out the speckle dermexanthesis, unconsciousness due to high fever, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, hematemesis and epistaxis, jaundice, laryngopharynx swelling and pain, sore throat, mumps, aphtha, swollen ulcer drug, mumps, epidemic cerebrospinal meningitis, epidemic encephalitis type B, upper respiratory tract infection, ancylostome, dermatitis, pyrexia of unknown origin, leptospira is separated lead poisoning etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 129th page).
Radix Scutellariae nature and flavor hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect.Can treat hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement etc.(the 248th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The Radix Angelicae Sinensis (processed with wine) nature and flavor are sweet, hot, warm.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.Can be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea stimulates the menstrual flow, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, traumatic injury, ulcer sores etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 553rd page).
Radix Paeoniae Rubra nature and flavor suffering, hardship, flavor are trembled with fear.Return Liver Channel.Has clearing away heat and cooling blood, the effect of eliminating stasis to stop pain.Can treat maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, traumatic injury, carbuncle skin infection etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 659th page).
Wine Zaocys nature and flavor are sweet, flat.Return Liver Channel.Have and dispel the wind, collateral dredging, the effect of relieving convulsion.Can treat rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus disease, leprosy scabies, scrofula malignant boil etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 339th page).
Radix Sophorae Flavescentis nature and flavor hardship, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel.Has heat clearing and damp drying, parasite killing, diuretic effect.Can treat hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis etc.(the 161st page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Caulis Spatholobi nature and flavor hardship, sweet, warm.Return liver, kidney channel.Have and enrich blood, invigorate blood circulation, the effect of collateral dredging.Can treat menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia etc.(the 151st page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Cortex Dictamni nature and flavor hardship, cold.Return spleen, stomach, urinary bladder channel.Has heat clearing and damp drying, the antidotal effect of dispeling the wind.Can treat damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, rheumatism pyretic arthralgia, jaundice dark coloured urine etc.(the 83rd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The Radix Scrophulariae nature and flavor are sweet, bitter, salty, are slightly cold.Return lung, stomach, kidney channel.Has the removing heat from blood YIN nourishing, the effect of eliminating fire and detoxication.Can treat consumption of YIN caused by febrile disease, the crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus etc.(the 88th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Fructus Kochiae nature and flavor suffering, hardship, cold.Return kidney, urinary bladder channel.Has clearing away heat-damp and promoting diuresis, the effect of dispelling wind for relieving itching.Can treat difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus etc.(the 93rd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Radix Rehmanniae, Rhizoma Smilacis Glabrae, Folium Isatidis and Radix Scutellariae, is ministerial drug with Radix Angelicae Sinensis (processed with wine), Radix Paeoniae Rubra, wine Zaocys, Radix Sophorae Flavescentis, Caulis Spatholobi and Cortex Dictamni, is adjuvant with the Radix Scrophulariae and the Fructus Kochiae.All medicine phases and the effect that is total to tool heat-clearing and toxic substances removing, YIN nourishing and the production of body fluid promoting, dispelling wind and removing obstruction in the collateral, blood cooling and ecchymoses removing.The treatment psoriasis has determined curative effect, has no side effect taking convenience, cheap characteristics.
Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, preferred Chinese medicine preparation is a peroral dosage form, as: tablet, capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment and the prevention psoriasis of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.
3, the present invention not only can effectively treat psoriasis, and psoriatic prevention is also had good effect, has improved patient's life quality greatly, and higher healing rehabilitation efficacy is arranged.
Further specify medicine of the present invention to treating psoriatic therapeutic effect below by the clinical practice example.
Psoriasis curative effect determinate standard (the 302nd page of " new Chinese medicine clinical research guideline " Zheng Xiao cornel chief editor Chinese Medicine science and technology publishing house in May, 2002 front page).
1, clinical recovery tcm clinical practice symptom, sign disappear or basic the disappearance; The sign integration reduces 〉=95%.
2, produce effects tcm clinical practice symptom, sign are obviously improved, and 95%>sign integration reduces 〉=70%.
3, improvement tcm clinical practice symptom, sign all take a favorable turn, and 70%>sign integration reduces 〉=50%.
4, invalid tcm clinical practice symptom, sign all do not have obvious improvement, even increase the weight of, the sign integration reduces less than 50%.
As follows through clinical test results; Treatment psoriatic 67 examples, male's 35 examples, women's 32 examples, the age is 18~65 years old.Take embodiment 1 capsule, each 2-10 grain, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.Two months is a course of treatment, take continuously three the course of treatment observe the curative effect.48 examples of fully recovering account for 71.64%, and produce effects 8 examples account for 11.94%, and 7 examples that take a turn for the better account for 10.44%, and invalid 4 examples account for 5.97%, and total effective rate reaches 94%.After three course of therapy, symptoms such as patient's erythema, pimple and squama etc. all have clear improvement or fully recover.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
Embodiment 1 capsule takes by weighing raw material by following weight:
5 parts of 5 parts of Radix Scutellariaes of 10 parts of Rhizoma Smilacis Glabraes of Radix Rehmanniae
3 parts of 3 parts of Radix Paeoniae Rubra of 5 parts of Radix Angelicae Sinensis (processed with wine) of Folium Isatidis
3 parts of 3 parts of Radix Sophorae Flavescentiss of 3 portions of Caulis Spatholobis of wine Zaocys
2 parts of 2 portions of Radix Scrophulariaes of 3 parts of Fructus Kochiae of Cortex Dictamni.
Preparation method is to get raw materials such as Radix Rehmanniae, Rhizoma Smilacis Glabrae, Folium Isatidis, Radix Scutellariae, Radix Angelicae Sinensis (processed with wine), Radix Paeoniae Rubra, wine Zaocys, Radix Sophorae Flavescentis, Caulis Spatholobi, Cortex Dictamni, Radix Scrophulariae and the Fructus Kochiae to decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, the clear paste of relative density 1.08~1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree~55 are concentrated into the clear paste of relative density 1.30~1.32, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2~10, three to four times on the one, two months is a course of treatment.
Embodiment 2 tablets take by weighing raw material by following weight:
5 parts of 5 parts of Radix Scutellariaes of 10 parts of Rhizoma Smilacis Glabraes of Radix Rehmanniae
3 parts of 3 parts of Radix Paeoniae Rubra of 5 parts of Radix Angelicae Sinensis (processed with wine) of Folium Isatidis
3 parts of 3 parts of Radix Sophorae Flavescentiss of 3 portions of Caulis Spatholobis of wine Zaocys
2 parts of 2 portions of Radix Scrophulariaes of 3 parts of Fructus Kochiae of Cortex Dictamni.
Preparation method is to get Radix Rehmanniae, Rhizoma Smilacis Glabrae, Folium Isatidis, Radix Scutellariae, Radix Angelicae Sinensis (processed with wine), Radix Paeoniae Rubra, the wine Zaocys, Radix Sophorae Flavescentis, Caulis Spatholobi, Cortex Dictamni, raw material such as the Radix Scrophulariae and the Fructus Kochiae decocts with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, the clear paste of relative density 1.08~1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree~55 are concentrated into the clear paste of relative density 1.30~1.32, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2~10, three to four times on the one, two months is a course of treatment.
Embodiment 3 granules take by weighing raw material by following weight:
5 parts of 5 parts of Radix Scutellariaes of 10 parts of Rhizoma Smilacis Glabraes of Radix Rehmanniae
3 parts of 3 parts of Radix Paeoniae Rubra of 5 parts of Radix Angelicae Sinensis (processed with wine) of Folium Isatidis
3 parts of 3 parts of Radix Sophorae Flavescentiss of 3 portions of Caulis Spatholobis of wine Zaocys
2 parts of 2 portions of Radix Scrophulariaes of 3 parts of Fructus Kochiae of Cortex Dictamni.
Preparation method is to get Radix Rehmanniae, Rhizoma Smilacis Glabrae, Folium Isatidis, Radix Scutellariae, Radix Angelicae Sinensis (processed with wine), Radix Paeoniae Rubra, the wine Zaocys, Radix Sophorae Flavescentis, Caulis Spatholobi, Cortex Dictamni, raw material such as the Radix Scrophulariae and the Fructus Kochiae decocts with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, and the clear paste of relative density 1.08~1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when 50 degree~55 are spent, be concentrated into the clear paste of relative density 1.30~1.32, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1~3 bag, three to four times on the one, two months is a course of treatment.