CN100571725C - A kind of Chinese medicine preparation for the treatment of sciatica - Google Patents
A kind of Chinese medicine preparation for the treatment of sciatica Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine preparation for the treatment of sciatica, it is that kind of Chinese herbal medicine is a raw material surplus Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Astragali and Caulis Piperis Kadsurae etc. 10.The present invention has expelling wind and removing dampness, the effect of dispersing cold for relieving pain.The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of sciatica.Have determined curative effect, safe ready, little, the cheap characteristics of side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of sciatica, is that a kind of sciatica for the treatment of is the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.
Background technology
Sciatica is meant along the pain of sciatic nerve path and areal area thereof, i.e. the pain in the outside and the foot outside behind buttocks, thigh rear side, shank.This is the caused a kind of symptom of multiple disease.When the diagnosis sciatica, should further find the primary disease that causes its outbreak.Constitutional and Secondary cases be can be divided into according to cause of disease difference, root and dryness sciatica are divided into again according to diseased region.The how acute or subacute morbidity of primary disease, minority is chronic, the course of disease can reach the several years to many decades, good sending out in the young and the middle aged, the male is in the majority.Sciatica belongs to categories such as the traditional Chinese medical science " painful loins and legs ", " waist hip pain ", " lumbago and skelalgia ", " lumbago ", " muscular rheumatism ".
Chinese medicine thinks that primary disease is the blockage of meridian of lower limb waist lower limb, due to QI-blood circulation is not smooth.Sciatica is sent out in person between twenty and fifty well, and is how one-sided, but the minority both sides alternately take place, pain is positioned at buttocks and lumbosacral region, and radiates to knee joint, the shank outside to outer ankle, is referred pain or causalgia, walking, activity and tractive sciatic nerve can make that the pain increased.Often with vasomotion and malnutrition, xerosis cutis and dysidria sometimes.The traditional Chinese medical science is divided into clinically: the cold passages through which vital energy circulates that stagnates, damp and hotly soak the dialectical treatments of disease type such as network, obstruction of collaterals by blood stasis, expectorant turbidity current notes, QI and blood deficiency, deficiency of the liver and kindey and obtain better curative effect, this patient mainly is bitter with pain, and pain be difficult for to be alleviated, so the traditional Chinese medical science has superiority in treatment, and does not recur.
Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of sciatica.Have determined curative effect, safe ready, little, the cheap characteristics of side effect.
The present invention is made by the following weight proportion raw material:
1.0～4 parts of 0.1～2 part of Radix Angelicae Sinensis of 0.1～2 part of Radix Aconiti Kusnezoffii Preparata of Radix Aconiti Preparata
0.1～1 part in 1.5～6 portions of Herba Ephedraes of 1.5～6 portions of Caulis Piperis Kadsuraes of Radix Astragali
1.0～4 parts of 0.1～2 portion of Radix Paeoniae Albas of 0.1～2 part of Myrrha (processed) of Olibanum (processed)
0.1～2 part in 0.05～0.15 portion of Radix Glycyrrhizae of 1.0～4 parts of Scolopendras of Cortex Acanthopancis
The weight proportion of each raw material of optimization formula of the present invention is:
1.5～2.5 parts of 0.5～1.5 part of Radix Angelicae Sinensis of 0.5～1.5 part of Radix Aconiti Kusnezoffii Preparata of Radix Aconiti Preparata
0.3～0.7 part in 2.5～3.5 portions of Herba Ephedraes of 2.5～3.5 portions of Caulis Piperis Kadsuraes of Radix Astragali
1.5～2.5 parts of 0.5～1.5 portion of Radix Paeoniae Albas of 0.5～1.5 part of Myrrha (processed) of Olibanum (processed)
0.5～1.5 part in 0.09～0.3 portion of Radix Glycyrrhizae of 1.5～2.5 parts of Scolopendras of Cortex Acanthopancis
The weight proportion of each raw material of optimum formula of the present invention is:
2 parts of 1 part of Radix Angelicae Sinensis of 1 part of Radix Aconiti Kusnezoffii Preparata of Radix Aconiti Preparata
0.5 part in 3 portions of Herba Ephedraes of 3 portions of Caulis Piperis Kadsuraes of Radix Astragali
2 parts of 1 portion of Radix Paeoniae Albas of 1 part of Myrrha (processed) of Olibanum (processed)
1 part in 0.1 portion of Radix Glycyrrhizae of 2 parts of Scolopendras of Cortex Acanthopancis
Drug action mechanism among the present invention is as follows:
Radix Aconiti Preparata nature and flavor suffering, hardship, heat, big poison.GUIXIN, liver,spleen,kidney warp.Has expelling wind and removing dampness, wet warp, the effect of dispersing cold for relieving pain.Cure mainly anemofrigid-damp arthralgia, numb limbs and tense tendons, hemiplegia, the wind syndrome of head headache, trusted subordinate's cold type of pain, colic of cold type is had a pain, traumatic injury stasis of blood pain, carbuncle of yin nature toxic swelling etc.(the 303rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Radix Aconiti Kusnezoffii Preparata nature and flavor suffering, hardship, heat, big poison.GUIXIN, liver, spleen channel.Expelling wind and removing dampness, dispelling cold by warming the meridian, the effect of reducing swelling and alleviating pain.Cure mainly anemofrigid-damp arthralgia, arthralgia, the wind syndrome of head headache, apoplectic dyscinesia, trusted subordinate's cold type of pain, colic of cold type is had a pain, traumatic injury, swelling and pain due to blood stasis, carbuncle of yin nature toxic swelling etc.(the 2130th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Radix Angelicae Sinensis nature and flavor are sweet, hot, warm.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.Can be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea stimulates the menstrual flow, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, traumatic injury, ulcer sores etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 553rd page).
The Radix Astragali nature and flavor are sweet, warm.Return lung, spleen channel.Have benefit and defend consolidating superficial resistance, inducing diuresis to remove edema, poison holding, the effect of granulation promoting.That can treat that internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle do not burst or burst does not hold back and the disease of all weakness of QI blood deficiency etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1074th page).
Caulis Piperis Kadsurae nature and flavor hardship, cold, nontoxic.GUIXIN, kidney channel.Has wind-damp dispelling, the meridian dredging, the effect of regulating QI to relieve pain.Cure mainly anemofrigid-damp arthralgia, arthrodynia of extremities, the contracture of muscle arteries and veins, coldness and pain in the epigastrium, edema etc.(the 2740th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Herba Ephedrae nature and flavor suffering, little hardship, temperature.Return lung, urinary bladder channel.Has relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, the effect of inducing diuresis to remove edema.Cure mainly chill exterior syndrome, cough and asthma, edema due to wind pathogen, dysuria, rheumatic arthralgia, numbness of the skin, rubella pruritus, carbuncle of yin nature sucutaneous nodule etc.(the 3094th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Olibanum (processed) nature and flavor suffering, hardship, temperature.GUIXIN, liver, spleen channel.Have and invigorate blood circulation, circulation of qi promoting, analgesic effect.Cure mainly trusted subordinate's pain, amenorrhea, dysmenorrhea, the stasis of blood stagnated and suffered from abdominal pain puerperal, traumatic injury stasis of blood pain, swollen ulcer drug, the sore being festered and unhealed etc.(the 1992nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Myrrha (processed) nature and flavor hardship, flat.GUIXIN, liver, spleen channel.Has blood stasis dispelling, detumescence, the effect of analgesic therapy.Cure mainly breast stomachache, dysmenorrhea, amenorrhea ， mass in the abdomen, treating swelling and pain by traumatic injury, carbuncle skin infection, conjunctival congestion and swelling pain etc.(the 1636th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Radix Paeoniae Alba nature and flavor hardship, acid, be slightly cold.Return liver, spleen channel.Effect with suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating, antibiotic, thrombocytosis.Can treat that the pain over the hypochondriac region, dysentery stomachache, night sweat, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, headache are dizzy, limb pain twin, blood deficiency and yellow complexion etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 432nd page).
Cortex Acanthopancis nature and flavor suffering, hardship, little sweet, temperature.Return liver, kidney channel.Has wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, the effect of the arteries and veins of invigorating blood circulation.Cure mainly anemofrigid-damp arthralgia, lumbocrural pain, the muscles and bones flaccidity is soft, children's's walking retardation in children, a little less than the body weakness with emaciation, traumatic injury, fracture, edema, beriberi, uncontrolled urination is itched etc.(the 513rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Scolopendra nature and flavor suffering, temperature, poisonous.Return Liver Channel.Effect with endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Can treat that infantile convulsion, tic spasm, middle air port are askew, hemiplegia, tetanus disease, rheumatoid arthritis stubborn, skin infection, scrofula, venom etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1238th page).
The Radix Glycyrrhizae nature and flavor are sweet, and are flat.Return spleen, stomach, the heart, lung meridian.Have and middle emergency lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription.Process with controlling weakness of the spleen and stomach, asthenia lack of appetite, stomachache loose stool, the anxious pain of extremity contraction, cardiopalmus, hysteria, consumptive lung disease cough; Give birth to controlling laryngopharynx swelling and pain, the carbuncle pyogenic infections from tumour or sore, infantile carbuncle reaches medicine, alimentary toxicosis etc.(the 792nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Astragali and Caulis Piperis Kadsurae; With Radix Angelicae Sinensis, Herba Ephedrae, Olibanum (processed), Myrrha (processed), the Radix Paeoniae Alba and Cortex Acanthopancis is ministerial drug; With Scolopendra and Radix Glycyrrhizae is adjuvant.All medicines are harmonious, and are total to the tool expelling wind and removing dampness, the effect of dispersing cold for relieving pain.Treatment sciatica determined curative effect, toxic and side effects is little, taking convenience.
Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.
Preparation of the present invention, peroral dosage form preferably, as: tablet capsule agent, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment sciatica of the Chinese medicine of respectively distinguishing the flavor of, and does not have chemical sweeting agent, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.
3, the present invention can treat sciatica effectively, has improved patient's life quality and the time greatly, and higher healing rehabilitation efficacy is arranged.
Further specify the therapeutic effect of medicine of the present invention below by the clinical practice example to the treatment sciatica.
For showing medicine of the present invention, as follows through clinical test results to the sciatica therapeutic effect; Treatment sciatica patient 41 examples, the age is 46～72 years old, male's 26 examples, women's 15 examples.Take embodiment 1 capsule, each 2-10 grain, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.Cure 20 examples and account for 48.78%, 18 examples that take a turn for the better account for 43.9%, and more 3 examples do not account for 7.3%, and total effective rate reaches more than 92%.After three course of therapy, symptoms such as patient's pain all have obvious change or recovery from illness.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
Embodiment 1 capsule takes by weighing raw material by following weight:
1 part of 3 parts of Rhizoma Typhonii of 5 parts of Radix Codonopsis of Radix Astragali
2 parts of 2 parts of stir-baked RHIIZOMA CURCUMAE with vinegar of 1 part of stir-baked RHIZOMA SPARGANII with vinegar of Radix Polygalae (processed)
5 parts of 1 part of Carapax Trionycis (processed with vinegar) of 3 parts of Pheretimas of Radix Cyathulae
1 part of 1 part of prepared RHIZOMA CHUAN XIONG with yellow rice wine of 3 portions of Scorpios of Bombyx Batryticatus
Preparation method is to get Carapax Trionycis (processed with vinegar) earlier, Scorpio and Bombyx Batryticatus drying and crushing to 120～200 order fine powders, get Radix Astragali again, Radix Codonopsis, Rhizoma Typhonii, Radix Polygalae (processed), stir-baked RHIZOMA SPARGANII with vinegar, stir-baked RHIIZOMA CURCUMAE with vinegar, Radix Cyathulae, Pheretima and prepared RHIZOMA CHUAN XIONG with yellow rice wine decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, and reclaimed ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and Carapax Trionycis (processed with vinegar), Scorpio and Bombyx Batryticatus fine powder mixing, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.
Embodiment 2 tablets take by weighing raw material by following weight:
1 part of 3 parts of Rhizoma Typhonii of 5 parts of Radix Codonopsis of Radix Astragali
2 parts of 2 parts of stir-baked RHIIZOMA CURCUMAE with vinegar of 1 part of stir-baked RHIZOMA SPARGANII with vinegar of Radix Polygalae (processed)
5 parts of 1 part of Carapax Trionycis (processed with vinegar) of 3 parts of Pheretimas of Radix Cyathulae
1 part of 1 part of prepared RHIZOMA CHUAN XIONG with yellow rice wine of 3 portions of Scorpios of Bombyx Batryticatus
Preparation method is to get Carapax Trionycis (processed with vinegar) earlier, Scorpio and Bombyx Batryticatus drying and crushing to 120～200 order fine powders, get Radix Astragali again, Radix Codonopsis, Rhizoma Typhonii, Radix Polygalae (processed), stir-baked RHIZOMA SPARGANII with vinegar, stir-baked RHIIZOMA CURCUMAE with vinegar, Radix Cyathulae, Pheretima and prepared RHIZOMA CHUAN XIONG with yellow rice wine decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, and reclaimed ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and Carapax Trionycis (processed with vinegar), Scorpio and Bombyx Batryticatus fine powder mixing, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.
Embodiment 3 granules take by weighing raw material by following weight:
1 part of 3 parts of Rhizoma Typhonii of 5 parts of Radix Codonopsis of Radix Astragali
2 parts of 2 parts of stir-baked RHIIZOMA CURCUMAE with vinegar of 1 part of stir-baked RHIZOMA SPARGANII with vinegar of Radix Polygalae (processed)
5 parts of 1 part of Carapax Trionycis (processed with vinegar) of 3 parts of Pheretimas of Radix Cyathulae
1 part of 1 part of prepared RHIZOMA CHUAN XIONG with yellow rice wine of 3 portions of Scorpios of Bombyx Batryticatus
Preparation method is to get Carapax Trionycis (processed with vinegar) earlier, Scorpio and Bombyx Batryticatus drying and crushing to 120～200 order fine powders, get Radix Astragali again, Radix Codonopsis, Rhizoma Typhonii, Radix Polygalae (processed), stir-baked RHIZOMA SPARGANII with vinegar, stir-baked RHIIZOMA CURCUMAE with vinegar, Radix Cyathulae, Pheretima and prepared RHIZOMA CHUAN XIONG with yellow rice wine decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and Carapax Trionycis (processed with vinegar), Scorpio and Bombyx Batryticatus fine powder mixing, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1～3 bag, three to four times on the one, one month is a course of treatment.
Claims (3)
1, a kind of Chinese medicine preparation for the treatment of sciatica is characterized in that it is made by following raw materials by weight proportions:
1.0～4 parts of 0.1～2 part of Radix Angelicae Sinensis of 0.1～2 part of Radix Aconiti Kusnezoffii Preparata of Radix Aconiti Preparata
0.1～1 part in 1.5～6 portions of Herba Ephedraes of 1.5～6 portions of Caulis Piperis Kadsuraes of Radix Astragali
1.0～4 parts of 0.1～2 portion of Radix Paeoniae Albas of 0.1～2 part of Myrrha (processed) of Olibanum (processed)
0.1～2 part in 0.05～0.15 portion of Radix Glycyrrhizae of 1.0～4 parts of Scolopendras of Cortex Acanthopancis.
2, a kind of Chinese medicine preparation for the treatment of sciatica according to claim 1, wherein the weight proportion of each crude drug is:
1.5～2.5 parts of 0.5～1.5 part of Radix Angelicae Sinensis of 0.5～1.5 part of Radix Aconiti Kusnezoffii Preparata of Radix Aconiti Preparata
0.3～0.7 part in 2.5～3.5 portions of Herba Ephedraes of 2.5～3.5 portions of Caulis Piperis Kadsuraes of Radix Astragali
1.5～2.5 parts of 0.5～1.5 portion of Radix Paeoniae Albas of 0.5～1.5 part of Myrrha (processed) of Olibanum (processed)
0.5～1.5 part in 0.09～0.3 portion of Radix Glycyrrhizae of 1.5～2.5 parts of Scolopendras of Cortex Acanthopancis.
3, a kind of Chinese medicine preparation for the treatment of sciatica according to claim 1, wherein the weight proportion of each crude drug is:
2 parts of 1 part of Radix Angelicae Sinensis of 1 part of Radix Aconiti Kusnezoffii Preparata of Radix Aconiti Preparata
0.5 part in 3 portions of Herba Ephedraes of 3 portions of Caulis Piperis Kadsuraes of Radix Astragali
2 parts of 1 portion of Radix Paeoniae Albas of 1 part of Myrrha (processed) of Olibanum (processed)
1 part in 0.1 portion of Radix Glycyrrhizae of 2 parts of Scolopendras of Cortex Acanthopancis.
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| 围场坝上地区坐骨神经痛诊治体会. 候青山.承德医学院学报，第11卷第4期. 1994 |
| 围场坝上地区坐骨神经痛诊治体会. 候青山.承德医学院学报，第11卷第4期. 1994 * |
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